AU2012225766B9 - Peptide linkers for polypeptide compositions and methods for using same - Google Patents

Peptide linkers for polypeptide compositions and methods for using same Download PDF

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Publication number
AU2012225766B9
AU2012225766B9 AU2012225766A AU2012225766A AU2012225766B9 AU 2012225766 B9 AU2012225766 B9 AU 2012225766B9 AU 2012225766 A AU2012225766 A AU 2012225766A AU 2012225766 A AU2012225766 A AU 2012225766A AU 2012225766 B9 AU2012225766 B9 AU 2012225766B9
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AU
Australia
Prior art keywords
peptide
amino acid
seq
acid sequence
linker
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Application number
AU2012225766A
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English (en)
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AU2012225766A1 (en
AU2012225766B2 (en
Inventor
Michael Concino
Paolo Martini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Human Genetics Therapies Inc
Original Assignee
Shire Human Genetics Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2011/041928 external-priority patent/WO2011163652A2/en
Application filed by Shire Human Genetics Therapies Inc filed Critical Shire Human Genetics Therapies Inc
Publication of AU2012225766A1 publication Critical patent/AU2012225766A1/en
Priority to AU2017204405A priority Critical patent/AU2017204405B2/en
Application granted granted Critical
Publication of AU2012225766B2 publication Critical patent/AU2012225766B2/en
Publication of AU2012225766B9 publication Critical patent/AU2012225766B9/en
Priority to AU2019202865A priority patent/AU2019202865B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/30Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/465Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/65Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0105Alpha-N-acetylglucosaminidase (3.2.1.50)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/35Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2012225766A 2011-03-04 2012-03-02 Peptide linkers for polypeptide compositions and methods for using same Active AU2012225766B9 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2017204405A AU2017204405B2 (en) 2011-03-04 2017-06-28 Peptide linkers for polypeptide compositions and methods for using same
AU2019202865A AU2019202865B2 (en) 2011-03-04 2019-04-24 Peptide linkers for polypeptide compositions and methods for using same

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161449225P 2011-03-04 2011-03-04
US61/449,225 2011-03-04
PCT/US2011/041928 WO2011163652A2 (en) 2010-06-25 2011-06-25 Treatment of sanfilippo syndrome type b
AUPCT/US2011/041928 2011-06-25
US13/168,969 2011-06-25
US13/168,969 US20110318327A1 (en) 2010-06-25 2011-06-25 Treatment of sanfilippo syndrome type b
PCT/US2012/027561 WO2012122042A2 (en) 2011-03-04 2012-03-02 Peptide linkers for polypeptide compositions and methods for using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017204405A Division AU2017204405B2 (en) 2011-03-04 2017-06-28 Peptide linkers for polypeptide compositions and methods for using same

Publications (3)

Publication Number Publication Date
AU2012225766A1 AU2012225766A1 (en) 2013-09-19
AU2012225766B2 AU2012225766B2 (en) 2017-07-13
AU2012225766B9 true AU2012225766B9 (en) 2017-08-31

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
AU2012225766A Active AU2012225766B9 (en) 2011-03-04 2012-03-02 Peptide linkers for polypeptide compositions and methods for using same
AU2017204405A Active AU2017204405B2 (en) 2011-03-04 2017-06-28 Peptide linkers for polypeptide compositions and methods for using same
AU2019202865A Expired - Fee Related AU2019202865B2 (en) 2011-03-04 2019-04-24 Peptide linkers for polypeptide compositions and methods for using same

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2017204405A Active AU2017204405B2 (en) 2011-03-04 2017-06-28 Peptide linkers for polypeptide compositions and methods for using same
AU2019202865A Expired - Fee Related AU2019202865B2 (en) 2011-03-04 2019-04-24 Peptide linkers for polypeptide compositions and methods for using same

Country Status (7)

Country Link
EP (1) EP2680879B1 (enExample)
JP (3) JP6175372B2 (enExample)
CN (2) CN106279433A (enExample)
AU (3) AU2012225766B9 (enExample)
BR (1) BR112013022557A2 (enExample)
CA (2) CA2828966C (enExample)
WO (1) WO2012122042A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8580922B2 (en) 2011-03-04 2013-11-12 Shire Human Genetic Therapies, Inc. Peptide linkers for polypeptide compositions and methods for using same
HUE039334T2 (hu) 2012-11-27 2018-12-28 Biomarin Pharm Inc Célzott terápiás lizoszómális enzim fúziós fehérjék és azok alkalmazásai
US10603364B2 (en) 2014-08-11 2020-03-31 Shire Human Genetic Therapies, Inc. Lysosomal targeting and uses thereof
MA41022A (fr) 2014-11-24 2017-10-03 Shire Human Genetic Therapies Ciblage lysosomial et utilisations correspondantes
US20220243210A1 (en) * 2019-05-17 2022-08-04 Ionis Pharmaceuticals, Inc. Angiotensin ii type 1 receptor targeted oligonucleotides and uses thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001005824A2 (en) * 1999-07-15 2001-01-25 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Synthetic peptides immunoreactive with hepatitis a virus antibodies
JP2005170810A (ja) * 2003-12-09 2005-06-30 Sanyo Chem Ind Ltd 細胞接着性ポリペプチド
US20060099218A1 (en) * 2002-10-01 2006-05-11 Dnavec Research Method of strengthening foreign epitope presentation by mhc class i by inhibiting tap activity
WO2006129085A2 (en) * 2005-06-01 2006-12-07 Medigene Limited High affinity melan-a t cell receptors
US20080039341A1 (en) * 2005-09-27 2008-02-14 Volker Schellenberger Unstructured recombinant polymers and uses thereof
WO2010080424A1 (en) * 2008-12-18 2010-07-15 E. I. Du Pont De Nemours And Company Peptide linkers for effective multivalent peptide binding
WO2011163652A2 (en) * 2010-06-25 2011-12-29 Shire Human Genetic Therapies, Inc. Treatment of sanfilippo syndrome type b

Family Cites Families (12)

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CA2222055A1 (en) * 1995-05-23 1996-11-28 Morphosys Gesellschaft Fur Proteinoptimierung Mbh Multimeric proteins
US20040181830A1 (en) * 2001-05-07 2004-09-16 Kovalic David K. Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
US7629309B2 (en) * 2002-05-29 2009-12-08 Zystor Therapeutics, Inc. Targeted therapeutic proteins
JP4897792B2 (ja) * 2005-04-20 2012-03-14 ビロメッド カンパニー, リミテッド 融合タンパク質の分離のための組成物および方法
GB0524987D0 (en) * 2005-12-08 2006-01-18 Ge Healthcare Ltd Novel imaging agents for fibrosis
GB0611463D0 (en) * 2006-06-09 2006-07-19 Novartis Ag Organic compounds
JP6035009B2 (ja) * 2007-08-22 2016-11-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用
WO2009062348A1 (en) * 2007-11-14 2009-05-22 Institute Of Microbiology, Chinese Academy Of Sciences Methods for inhibiting influenza virus infection and their drugs
CN101186637B (zh) * 2007-11-14 2011-09-14 中国科学院微生物研究所 抑制流感病毒感染的方法及其药物
HRP20170698T1 (hr) 2008-05-07 2017-09-22 Biomarin Pharmaceutical Inc. Lizosomski usmjereni peptidi i njihove uporabe
TWI496582B (zh) * 2008-11-24 2015-08-21 必治妥美雅史谷比公司 雙重專一性之egfr/igfir結合分子
WO2010088411A2 (en) * 2009-01-30 2010-08-05 Adlyfe, Inc. Conformationally dynamic peptides

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001005824A2 (en) * 1999-07-15 2001-01-25 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Synthetic peptides immunoreactive with hepatitis a virus antibodies
US20060099218A1 (en) * 2002-10-01 2006-05-11 Dnavec Research Method of strengthening foreign epitope presentation by mhc class i by inhibiting tap activity
JP2005170810A (ja) * 2003-12-09 2005-06-30 Sanyo Chem Ind Ltd 細胞接着性ポリペプチド
WO2006129085A2 (en) * 2005-06-01 2006-12-07 Medigene Limited High affinity melan-a t cell receptors
US20080039341A1 (en) * 2005-09-27 2008-02-14 Volker Schellenberger Unstructured recombinant polymers and uses thereof
WO2010080424A1 (en) * 2008-12-18 2010-07-15 E. I. Du Pont De Nemours And Company Peptide linkers for effective multivalent peptide binding
WO2011163652A2 (en) * 2010-06-25 2011-12-29 Shire Human Genetic Therapies, Inc. Treatment of sanfilippo syndrome type b

Also Published As

Publication number Publication date
CN106279433A (zh) 2017-01-04
CA3080181A1 (en) 2012-09-13
EP2680879B1 (en) 2021-01-06
BR112013022557A2 (pt) 2017-08-01
AU2019202865A1 (en) 2019-05-16
CA2828966A1 (en) 2012-09-13
JP2019150065A (ja) 2019-09-12
CA2828966C (en) 2020-07-14
CN103764162A (zh) 2014-04-30
JP2016187358A (ja) 2016-11-04
AU2019202865B2 (en) 2021-04-01
AU2017204405A1 (en) 2017-07-20
EP2680879A4 (en) 2015-09-02
AU2012225766A1 (en) 2013-09-19
WO2012122042A2 (en) 2012-09-13
EP2680879A2 (en) 2014-01-08
JP6594833B2 (ja) 2019-10-23
CN103764162B (zh) 2017-03-08
AU2017204405B2 (en) 2019-05-09
WO2012122042A3 (en) 2014-03-13
AU2012225766B2 (en) 2017-07-13
JP6175372B2 (ja) 2017-08-02
JP2014515595A (ja) 2014-07-03

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