AU2012222869B2 - Methods of treating a disease or condition of the central nervous system - Google Patents
Methods of treating a disease or condition of the central nervous system Download PDFInfo
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- AU2012222869B2 AU2012222869B2 AU2012222869A AU2012222869A AU2012222869B2 AU 2012222869 B2 AU2012222869 B2 AU 2012222869B2 AU 2012222869 A AU2012222869 A AU 2012222869A AU 2012222869 A AU2012222869 A AU 2012222869A AU 2012222869 B2 AU2012222869 B2 AU 2012222869B2
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- alkyl
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- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
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- 229940037001 sodium edetate Drugs 0.000 description 1
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- KAKQVSNHTBLJCH-UHFFFAOYSA-N trifluoromethanesulfonimidic acid Chemical compound NS(=O)(=O)C(F)(F)F KAKQVSNHTBLJCH-UHFFFAOYSA-N 0.000 description 1
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- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
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- OYPPVKRFBIWMSX-SXGWCWSVSA-N zimeldine Chemical compound C=1C=CN=CC=1C(=C/CN(C)C)\C1=CC=C(Br)C=C1 OYPPVKRFBIWMSX-SXGWCWSVSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2012222869A AU2012222869B2 (en) | 2011-03-02 | 2012-03-02 | Methods of treating a disease or condition of the central nervous system |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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AU2011900737A AU2011900737A0 (en) | 2011-03-02 | Methods of Treating a Disease or Condition of the Central Nervous System | |
AU2011900737 | 2011-03-02 | ||
AU2012222869A AU2012222869B2 (en) | 2011-03-02 | 2012-03-02 | Methods of treating a disease or condition of the central nervous system |
PCT/AU2012/000216 WO2012116410A1 (fr) | 2011-03-02 | 2012-03-02 | Méthodes de traitement d'une maladie ou d'un état pathologique du système nerveux central |
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AU2012222869A1 AU2012222869A1 (en) | 2013-03-14 |
AU2012222869B2 true AU2012222869B2 (en) | 2015-08-13 |
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AU2012222869A Ceased AU2012222869B2 (en) | 2011-03-02 | 2012-03-02 | Methods of treating a disease or condition of the central nervous system |
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US (1) | US20140051701A1 (fr) |
EP (1) | EP2680842A4 (fr) |
AU (1) | AU2012222869B2 (fr) |
WO (1) | WO2012116410A1 (fr) |
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US10954231B2 (en) | 2006-10-16 | 2021-03-23 | Bionomics Limited | Anxiolytic compounds |
CA2954376C (fr) | 2006-10-16 | 2019-06-11 | Bionomics Limited | Nouveaux composes anxiolytiques |
JP2014510065A (ja) | 2011-03-02 | 2014-04-24 | バイオノミックス リミテッド | 治療薬としての新規な小分子 |
EP2707367B1 (fr) * | 2011-05-12 | 2019-10-09 | Bionomics Limited | Procédés pour la préparation de naphtyridines |
AU2014231722B2 (en) | 2013-03-15 | 2016-12-22 | Bionomics Limited | Salts, co-crystals, and polymorphs of an anxiolytic compound |
AU2013204159B2 (en) * | 2013-03-15 | 2015-05-07 | Bionomics Limited | A Crystalline Form of an Anxiolytic Compound |
WO2018102885A1 (fr) * | 2016-12-09 | 2018-06-14 | Bionomics Limited | Modulateurs des récepteurs nicotiniques de l'acétylcholine et leurs utilisations |
WO2019109150A1 (fr) * | 2017-12-07 | 2019-06-13 | Bionomics Limited | Procédés de traitement de l'agitation |
CA3218884A1 (fr) * | 2021-05-11 | 2022-11-17 | David Nutt | Composes et compositions therapeutiques a base d'aminoindane |
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- 2012-03-02 US US14/002,536 patent/US20140051701A1/en not_active Abandoned
- 2012-03-02 EP EP12751882.7A patent/EP2680842A4/fr not_active Withdrawn
- 2012-03-02 WO PCT/AU2012/000216 patent/WO2012116410A1/fr active Application Filing
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WO2002069948A1 (fr) * | 2001-03-01 | 2002-09-12 | Pfizer Products Inc. | Utilisation d'agonistes inverses de gabaa combines avec des agonistes partiels de recepteurs nicotiniques, un oestrogene, des modulateurs selectifs des recepteurs des oestrogenes ou la vitamine e pour le traitement de troubles cognitifs |
WO2003097564A2 (fr) * | 2002-05-14 | 2003-11-27 | The Regents Of The University Of California | Acides quinolone carboxyliques substitues, derives de ces derniers, site d'action et utilisations de ces derniers |
WO2007106537A2 (fr) * | 2006-03-13 | 2007-09-20 | Activx Biosciences, Inc. | Aminoquinolones utilisées comme inhibiteurs de la gsk-3 |
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WO2010073078A2 (fr) * | 2008-12-22 | 2010-07-01 | Orchid Research Laboratories Ltd. | Composés hétérocycliques comme inhibiteurs de hdac |
Also Published As
Publication number | Publication date |
---|---|
US20140051701A1 (en) | 2014-02-20 |
WO2012116410A1 (fr) | 2012-09-07 |
EP2680842A4 (fr) | 2014-10-29 |
AU2012222869A1 (en) | 2013-03-14 |
EP2680842A1 (fr) | 2014-01-08 |
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