AU2012222074A1 - Chalcone derivatives as Nrf2 activators - Google Patents

Chalcone derivatives as Nrf2 activators Download PDF

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Publication number
AU2012222074A1
AU2012222074A1 AU2012222074A AU2012222074A AU2012222074A1 AU 2012222074 A1 AU2012222074 A1 AU 2012222074A1 AU 2012222074 A AU2012222074 A AU 2012222074A AU 2012222074 A AU2012222074 A AU 2012222074A AU 2012222074 A1 AU2012222074 A1 AU 2012222074A1
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Prior art keywords
och
disease
compound
nrf2
group
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AU2012222074A
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Inventor
Shyam Biswal
Kim JUNG-HYUN
Sarvesh Kumar
Vineet Kumar
Sanjay V. Malhotra
Rajesh THIMMULAPPA
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Johns Hopkins University
National Institutes of Health NIH
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Johns Hopkins University
National Institutes of Health NIH
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Publication of AU2012222074A1 publication Critical patent/AU2012222074A1/en
Assigned to THE JOHNS HOPKINS UNIVERSITY, NATIONAL INSTITUTES OF HEALTH reassignment THE JOHNS HOPKINS UNIVERSITY Request for Assignment Assignors: THE JOHNS HOPKINS UNIVERSITY
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups

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AU2012222074A 2011-02-25 2012-02-27 Chalcone derivatives as Nrf2 activators Abandoned AU2012222074A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161446716P 2011-02-25 2011-02-25
US61/446,716 2011-02-25
US201161500272P 2011-06-23 2011-06-23
US61/500,272 2011-06-23
PCT/US2012/026744 WO2012116362A2 (en) 2011-02-25 2012-02-27 Chalcone derivatives as nrf2 activators

Publications (1)

Publication Number Publication Date
AU2012222074A1 true AU2012222074A1 (en) 2013-09-12

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AU2012222074A Abandoned AU2012222074A1 (en) 2011-02-25 2012-02-27 Chalcone derivatives as Nrf2 activators

Country Status (6)

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US (1) US20140088052A1 (enExample)
EP (1) EP2678305A4 (enExample)
JP (1) JP2014510064A (enExample)
AU (1) AU2012222074A1 (enExample)
CA (1) CA2827990A1 (enExample)
WO (1) WO2012116362A2 (enExample)

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WO2012174436A1 (en) 2011-06-15 2012-12-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nuclear receptor modulators and their use for the treatment and prevention of cancer
WO2015187934A1 (en) * 2014-06-06 2015-12-10 Cureveda, Llc Functionalized hetroaryl enones exhibiting nrf2 activation and their method of use
ES2570452B1 (es) * 2014-10-15 2017-04-19 Fundación Para La Investigación Biomédida Del Hospital Universitario De La Princesa Compuestos derivados de acrilato de 3-Alquilamino-1H-Indolilo y su uso en el tratamiento de enfermedades neurodegenerativas
MA40990A (fr) * 2014-11-19 2017-09-26 Biogen Ma Inc Formulations de matrice pharmaceutique comprenant du fumarate de diméthyle
WO2016153432A1 (en) * 2015-03-23 2016-09-29 Nanyang Polytechnic Drugs from substituted phenyl cinnamyl ketones
WO2017205795A1 (en) * 2016-05-26 2017-11-30 The Regents Of The University Of California Compounds and methods for hematopoietic regeneration
UY37551A (es) * 2016-12-27 2018-07-31 Biogen Ma Inc Activador de nrf2
CN107056707B (zh) * 2017-01-23 2019-08-23 温州医科大学 一种3,4,5-三甲氧基苯类化合物及其在制备抗氧化药物中的应用
AU2019326368B2 (en) 2018-08-20 2021-11-11 Janssen Pharmaceutica Nv Inhibitors of KEAP1-Nrf2 protein-protein interaction
WO2020094767A1 (en) * 2018-11-08 2020-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of nrf2 activators for the treatment of staphylococcus aureus infections
CN111792990A (zh) * 2019-04-09 2020-10-20 中国科学院上海药物研究所 一种不饱和酮类化合物、其制备方法和用途
EP4117642A4 (en) * 2020-03-13 2024-05-15 The Trustees Of Columbia University In The City Of New York Gpx4 compounds and compositions and methods of treatment using same
WO2022148850A1 (en) * 2021-01-07 2022-07-14 Philip Morris Products S.A. Compositions comprising anatabine and uses thereof
KR20240064627A (ko) * 2021-07-15 2024-05-13 알스핌 Il-23 발현과 관련된 질병을 예방 및/또는 치료하기 위한 조성물 및 방법
US11896719B2 (en) 2022-01-24 2024-02-13 Calliditas Therapeutics Ab Pharmaceutical compositions
CN115572255A (zh) * 2022-04-29 2023-01-06 无锡捷化医药科技有限公司 一种查尔酮类化合物的制备方法
CN115433073B (zh) * 2022-08-15 2024-04-19 兰州大学 一种卡瓦胡椒素b类似物的制备方法及其用途

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JPH0740105B2 (ja) * 1986-03-14 1995-05-01 清蔵 宮田 非線形光学素子
JPH02178249A (ja) * 1988-12-28 1990-07-11 Mitsubishi Kasei Corp 光学活性ケトンの製造法
US20030065039A1 (en) * 1997-06-26 2003-04-03 Statens Serum Institute Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones
DE69813853T3 (de) * 1997-09-29 2011-05-12 Novartis Ag Perforierte mikroteilchen und deren verwendung
WO2000018390A1 (fr) * 1998-09-28 2000-04-06 Hsp Research Institute, Inc. Inducteurs d'expression de proteine de choc thermique
WO2003033662A2 (en) * 2001-10-16 2003-04-24 Atherogenics, Inc. Protection against oxidative stress and inflammation by a cytoprotective response element
JP2008527002A (ja) * 2005-01-13 2008-07-24 サートリス ファーマシューティカルズ， インコーポレイテッド 神経変性障害および血液凝固障害を予防および処置するための新規組成物
KR100830541B1 (ko) * 2006-08-11 2008-05-21 충남대학교산학협력단 인터루킨-5 저해효과를 갖는 신규 찰콘계 유도체

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CA2827990A1 (en) 2012-08-30
EP2678305A2 (en) 2014-01-01
US20140088052A1 (en) 2014-03-27
WO2012116362A2 (en) 2012-08-30
EP2678305A4 (en) 2015-11-04
WO2012116362A3 (en) 2012-11-29
JP2014510064A (ja) 2014-04-24

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