AU2011327931B2 - Conjugates and their uses in molecular imaging - Google Patents

Conjugates and their uses in molecular imaging Download PDF

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Publication number
AU2011327931B2
AU2011327931B2 AU2011327931A AU2011327931A AU2011327931B2 AU 2011327931 B2 AU2011327931 B2 AU 2011327931B2 AU 2011327931 A AU2011327931 A AU 2011327931A AU 2011327931 A AU2011327931 A AU 2011327931A AU 2011327931 B2 AU2011327931 B2 AU 2011327931B2
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AU
Australia
Prior art keywords
bifunctional
bifunctional compound
group
molecular imaging
radionuclide
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Active
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AU2011327931A
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English (en)
Other versions
AU2011327931A2 (en
AU2011327931A1 (en
Inventor
James Russell Ballinger
David Berry
Philip John Blower
Yongmin Ma
Gregory Edgar David Mullen
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Kings College London
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Kings College London
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Publication date
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Publication of AU2011327931A1 publication Critical patent/AU2011327931A1/en
Publication of AU2011327931A2 publication Critical patent/AU2011327931A2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A61K51/1033—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants against receptors for cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
AU2011327931A 2010-11-11 2011-11-11 Conjugates and their uses in molecular imaging Active AU2011327931B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1019118.7 2010-11-11
GB201019118A GB201019118D0 (en) 2010-11-11 2010-11-11 Conjugates and their uses in molecular imaging
PCT/GB2011/001599 WO2012063028A1 (en) 2010-11-11 2011-11-11 Conjugates and their uses in molecular imaging

Publications (3)

Publication Number Publication Date
AU2011327931A1 AU2011327931A1 (en) 2013-07-04
AU2011327931A2 AU2011327931A2 (en) 2013-07-11
AU2011327931B2 true AU2011327931B2 (en) 2017-02-23

Family

ID=43431334

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011327931A Active AU2011327931B2 (en) 2010-11-11 2011-11-11 Conjugates and their uses in molecular imaging

Country Status (7)

Country Link
US (1) US9138495B2 (https=)
EP (1) EP2637705B1 (https=)
JP (1) JP5986095B2 (https=)
AU (1) AU2011327931B2 (https=)
ES (1) ES2625829T3 (https=)
GB (1) GB201019118D0 (https=)
WO (1) WO2012063028A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7098442B2 (en) 2003-03-05 2006-08-29 Raytheon Company Thin micropolarizing filter, and a method for making it
CN103561771B (zh) 2011-03-17 2019-01-04 伯明翰大学 重新定向的免疫治疗
JP7023604B2 (ja) 2013-10-31 2022-02-22 ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド 近赤外蛍光造影バイオイメージング剤及びその使用方法
US11001562B2 (en) 2013-10-31 2021-05-11 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
GB201417067D0 (en) 2014-09-26 2014-11-12 South African Nuclear Energy Radiopharmaceutical conjugate
GB201504064D0 (en) * 2015-03-10 2015-04-22 Accretion Biotechnology Ltd Method and kits for preparing radionuclide complexes
JP7253762B2 (ja) * 2017-12-27 2023-04-07 慈濟大學 タンパク質を表面に発現させた小胞によるオートファジー細胞およびアポトーシス細胞への薬剤送達
US12440585B2 (en) 2023-09-12 2025-10-14 Curadel Surgical Innovations, Inc. Zwitterionic metal chelators
CN120590625A (zh) * 2024-11-06 2025-09-05 江苏申命医疗科技有限公司 一种放射性核素标记的聚合物、其制备方法及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009021947A1 (en) * 2007-08-13 2009-02-19 Ge Healthcare As Chelators, paramagnetic chelates thereof and their use as contrast agents in magnetic resonance imaging (mri)

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
ES2156149T3 (es) 1992-12-04 2001-06-16 Medical Res Council Proteinas de union multivalente y multiespecificas, su fabricacion y su uso.
AU2865995A (en) 1995-06-14 1997-01-15 Regents Of The University Of California, The 3-hydroxy-2(1h)-pyridinone chelating agents
US8926945B2 (en) * 2005-10-07 2015-01-06 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
US8158804B2 (en) 2007-01-11 2012-04-17 Ge Healthcare As Chelating agents
US9209965B2 (en) 2014-01-14 2015-12-08 Microsemi Semiconductor Ulc Network interface with clock recovery module on line card

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009021947A1 (en) * 2007-08-13 2009-02-19 Ge Healthcare As Chelators, paramagnetic chelates thereof and their use as contrast agents in magnetic resonance imaging (mri)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FERNANDES, S. S. et al., "Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium", Microbes and Infection. 2010, vol. 12, no. 4, pages 287-294 *
ZHOU, T. et al., "Iron Binding Dendrimers: A Novel Approach for the Treatment of Haemochromatosis", Journal of Medicinal Chemistry. 2006, vol. 49, pages 4171-4182 *

Also Published As

Publication number Publication date
GB201019118D0 (en) 2010-12-29
EP2637705B1 (en) 2017-03-29
AU2011327931A2 (en) 2013-07-11
JP2014501714A (ja) 2014-01-23
EP2637705A1 (en) 2013-09-18
AU2011327931A1 (en) 2013-07-04
ES2625829T3 (es) 2017-07-20
US20140056810A1 (en) 2014-02-27
US9138495B2 (en) 2015-09-22
JP5986095B2 (ja) 2016-09-06
WO2012063028A1 (en) 2012-05-18

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 07 JUN 2013

DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ BALLINGER, JAMES RUSSELL; BERRY, DAVID; BLOWER, PHILIP JOHN; MA, YONGMIN AND MULLEN, GREGORY EDGAR DAVID

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ BALLINGER, JAMES RUSSELL; BERRY, DAVID; BLOWER, PHILIP JOHN; MA, YONGMIN AND MULLEN, GREGORY EDGAR DAVID

FGA Letters patent sealed or granted (standard patent)