AU2011291579B2 - Nicotinic receptor compounds - Google Patents
Nicotinic receptor compounds Download PDFInfo
- Publication number
- AU2011291579B2 AU2011291579B2 AU2011291579A AU2011291579A AU2011291579B2 AU 2011291579 B2 AU2011291579 B2 AU 2011291579B2 AU 2011291579 A AU2011291579 A AU 2011291579A AU 2011291579 A AU2011291579 A AU 2011291579A AU 2011291579 B2 AU2011291579 B2 AU 2011291579B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- azabicyclo
- pyridinyl
- heptane
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 257
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- 125000000217 alkyl group Chemical group 0.000 claims description 56
- 150000003839 salts Chemical class 0.000 claims description 48
- 125000001424 substituent group Chemical group 0.000 claims description 41
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- 125000003545 alkoxy group Chemical group 0.000 claims description 28
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 22
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
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- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37563010P | 2010-08-20 | 2010-08-20 | |
| US61/375,630 | 2010-08-20 | ||
| PCT/US2011/048470 WO2012024615A1 (en) | 2010-08-20 | 2011-08-19 | Nicotinic receptor compounds |
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| AU2011291579A1 AU2011291579A1 (en) | 2013-03-14 |
| AU2011291579B2 true AU2011291579B2 (en) | 2016-11-10 |
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| CA2809028C (en) * | 2010-08-20 | 2019-04-09 | Research Triangle Institute | Nicotinic receptor compounds |
| US9150581B2 (en) | 2011-12-28 | 2015-10-06 | Research Triangle Institute | Nicotinic receptor compounds |
| US11572374B2 (en) | 2018-08-14 | 2023-02-07 | Amgen Inc. | N-cyano-7-azanorbornane derivatives and uses thereof |
| CN109762007B (zh) * | 2019-02-27 | 2021-05-11 | 大连联化化学有限公司 | 一种合成n-取代-1,2,5,6-四氢吡啶-4-硼酸酯的工艺方法 |
| CN113773247A (zh) * | 2021-07-23 | 2021-12-10 | 无锡海伦生物科技有限公司 | 一种2-氨基-5-碘吡啶的制备方法 |
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| EP0955301A3 (en) | 1998-04-27 | 2001-04-18 | Pfizer Products Inc. | 7-aza-bicyclo[2.2.1]-heptane derivatives, their preparation and use according to their affinity for neuronal nicotinic acetylcholine receptors |
| US6538010B1 (en) | 2000-11-08 | 2003-03-25 | Research Triangle Institute | Compounds and methods for promoting smoking cessation |
| WO2009081246A2 (en) * | 2007-12-19 | 2009-07-02 | Pfizer Inc. | Bicyclic diamines as nicotinic receptor agonists |
| JP2012511527A (ja) * | 2008-12-12 | 2012-05-24 | バイエル ファーマ アクチエンゲゼルシャフト | 陽電子放出アイソトープ標識のためのトリアリール−スルホニウム化合物、キット及び方法 |
| US8846661B2 (en) * | 2009-06-19 | 2014-09-30 | Abbvie Inc. | Diazahomoadamantane derivatives and methods of use thereof |
| CA2809028C (en) * | 2010-08-20 | 2019-04-09 | Research Triangle Institute | Nicotinic receptor compounds |
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2015
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Non-Patent Citations (3)
| Title |
|---|
| Gao Y et al. 'Improved syntheses of precursors for PET radioligands [18F]XTRA and [18F]AZAN' Tetrahedron Letters, 2010, Vol 51 page 5333-5335 * |
| Gao Y et al. Journal of Medicinal Chemistry, 2007, vol 50, page 3814-3824 * |
| Gao Y et al. Journal of Medicinal Chemistry, 2008, Vol 51, page 4751-4764 * |
Also Published As
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| CA2809028C (en) | 2019-04-09 |
| US9284322B2 (en) | 2016-03-15 |
| JP5878532B2 (ja) | 2016-03-08 |
| EP2606052B1 (en) | 2016-06-01 |
| US20150152119A1 (en) | 2015-06-04 |
| US20130150373A1 (en) | 2013-06-13 |
| AU2011291579A1 (en) | 2013-03-14 |
| JP2013534255A (ja) | 2013-09-02 |
| ES2576282T3 (es) | 2016-07-06 |
| WO2012024615A1 (en) | 2012-02-23 |
| US8981102B2 (en) | 2015-03-17 |
| EP2606052A1 (en) | 2013-06-26 |
| CA2809028A1 (en) | 2012-02-23 |
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