AU2011274224A1 - Keloid treatment - Google Patents
Keloid treatment Download PDFInfo
- Publication number
- AU2011274224A1 AU2011274224A1 AU2011274224A AU2011274224A AU2011274224A1 AU 2011274224 A1 AU2011274224 A1 AU 2011274224A1 AU 2011274224 A AU2011274224 A AU 2011274224A AU 2011274224 A AU2011274224 A AU 2011274224A AU 2011274224 A1 AU2011274224 A1 AU 2011274224A1
- Authority
- AU
- Australia
- Prior art keywords
- glutamine
- alanyl
- keloid
- formation
- keloid scar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010023330 Keloid scar Diseases 0.000 title claims abstract description 31
- 208000002260 Keloid Diseases 0.000 title description 7
- 210000001117 keloid Anatomy 0.000 title description 7
- 238000011282 treatment Methods 0.000 title description 6
- HJCMDXDYPOUFDY-WHFBIAKZSA-N Ala-Gln Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O HJCMDXDYPOUFDY-WHFBIAKZSA-N 0.000 claims abstract description 17
- 229960002648 alanylglutamine Drugs 0.000 claims abstract description 16
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 48
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 38
- 230000036573 scar formation Effects 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 238000011200 topical administration Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 abstract description 15
- 230000015572 biosynthetic process Effects 0.000 abstract description 13
- 231100000241 scar Toxicity 0.000 abstract description 10
- 108010044940 alanylglutamine Proteins 0.000 abstract description 9
- 238000009472 formulation Methods 0.000 abstract description 6
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- 230000009467 reduction Effects 0.000 abstract description 3
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- 230000006378 damage Effects 0.000 description 15
- 108010016626 Dipeptides Proteins 0.000 description 12
- 229930182816 L-glutamine Natural products 0.000 description 10
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- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
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- MXCVHSXCXPHOLP-UHFFFAOYSA-N 4-oxo-6-propylchromene-2-carboxylic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=CC(CCC)=CC=C21 MXCVHSXCXPHOLP-UHFFFAOYSA-N 0.000 description 1
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- 208000028399 Critical Illness Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
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- 108010049003 Fibrinogen Proteins 0.000 description 1
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- 206010021928 Infertility female Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000012868 Overgrowth Diseases 0.000 description 1
- 241001387976 Pera Species 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 206010041101 Small intestinal obstruction Diseases 0.000 description 1
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- 230000003187 abdominal effect Effects 0.000 description 1
- 238000012084 abdominal surgery Methods 0.000 description 1
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- 230000006978 adaptation Effects 0.000 description 1
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- 210000001789 adipocyte Anatomy 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 1
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- 230000001580 bacterial effect Effects 0.000 description 1
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- 238000002845 discoloration Methods 0.000 description 1
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- 229940012952 fibrinogen Drugs 0.000 description 1
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- 235000019322 gelatine Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 1
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- NZHGWWWHIYHZNX-CSKARUKUSA-N tranilast Chemical compound C1=C(OC)C(OC)=CC=C1\C=C\C(=O)NC1=CC=CC=C1C(O)=O NZHGWWWHIYHZNX-CSKARUKUSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35905310P | 2010-06-28 | 2010-06-28 | |
| US61/359,053 | 2010-06-28 | ||
| PCT/CA2011/050396 WO2012000113A1 (en) | 2010-06-28 | 2011-06-28 | Keloid treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2011274224A1 true AU2011274224A1 (en) | 2013-01-17 |
| AU2011274224A8 AU2011274224A8 (en) | 2014-09-18 |
Family
ID=45401271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2011274224A Abandoned AU2011274224A1 (en) | 2010-06-28 | 2011-06-28 | Keloid treatment |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20140005116A1 (enExample) |
| EP (1) | EP2585090A4 (enExample) |
| JP (1) | JP2013533867A (enExample) |
| KR (1) | KR20130089174A (enExample) |
| CN (1) | CN103002903B (enExample) |
| AU (1) | AU2011274224A1 (enExample) |
| BR (1) | BR112012033349A2 (enExample) |
| CA (1) | CA2804413A1 (enExample) |
| CO (1) | CO6680624A2 (enExample) |
| MX (1) | MX2013000107A (enExample) |
| RU (1) | RU2578426C2 (enExample) |
| WO (1) | WO2012000113A1 (enExample) |
| ZA (1) | ZA201209759B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12318406B2 (en) | 2013-03-15 | 2025-06-03 | Cda Research Group, Inc. | Methods of treatment using topical copper ion formulations |
| US11000545B2 (en) | 2013-03-15 | 2021-05-11 | Cda Research Group, Inc. | Copper ion compositions and methods of treatment for conditions caused by coronavirus and influenza |
| US11318089B2 (en) | 2013-03-15 | 2022-05-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of making topical copper ion treatments for use in various anatomical areas of the body |
| US10398733B2 (en) | 2013-03-15 | 2019-09-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the dermatological areas of the body |
| FR3004353B1 (fr) * | 2013-04-10 | 2015-05-15 | Fabre Pierre Dermo Cosmetique | Association synergique de l'alanine-glutamine, l'acide hyaluronique et un extrait d'avoine, et son utilisation dans une composition destinee a la cicatrisation et la reparation des lesions cutanees |
| KR101800788B1 (ko) * | 2017-03-31 | 2017-11-27 | 박영오 | 켈로이드 흉터 개선용 화장료 조성물 |
| US10500318B1 (en) * | 2018-07-03 | 2019-12-10 | Temple Therapeutics BV | Dosing regimens for treating hypoxia-associated tissue damage |
| US11193184B2 (en) | 2019-02-22 | 2021-12-07 | Cda Research Group, Inc. | System for use in producing a metal ion suspension and process of using same |
| CN114767590B (zh) * | 2022-04-20 | 2024-03-15 | 上海交通大学医学院附属第九人民医院 | 一种祛疤祛痘印美容液及其制备方法与应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5740409A (en) * | 1980-08-22 | 1982-03-06 | Mitsui Toatsu Chem Inc | Remedy for disease caused by extraordinary propagation of collagen |
| US6149925A (en) * | 1998-11-05 | 2000-11-21 | Color Access, Inc. | Topical compositions for enhancing glutathione production |
| AU7067200A (en) * | 1999-08-23 | 2001-03-19 | Organogenesis Inc. | Skin care compositions and treatments |
| WO2002087576A1 (en) * | 2001-04-30 | 2002-11-07 | Arachnova Therapeutics Ltd. | The treatment of scarring and related conditions using ppar-gamma activators |
| US20030105025A1 (en) * | 2001-10-31 | 2003-06-05 | Fortuna Haviv | Tri-and tetrapeptides having antiangiogenic activity |
| RU2234963C2 (ru) * | 2002-09-16 | 2004-08-27 | Сибирский государственный медицинский университет | Способ лечения гипертрофических и келоидных кожных рубцов |
| AU2004279314B2 (en) * | 2003-09-12 | 2010-12-09 | The Regents Of The University Of Colorado, A Body Corporate | Glutamine for use in treating injury |
| RU2275216C1 (ru) * | 2004-12-08 | 2006-04-27 | Елена Григорьевна Арий | Способ профилактики формирования патологических кожных рубцов |
| AU2006279218B2 (en) * | 2005-08-11 | 2013-05-02 | Adetherapeutics, Inc. | Reducing post-operative adhesion formation with intraperitoneal glutamine |
| WO2007056068A2 (en) * | 2005-11-02 | 2007-05-18 | Bentley Pharmaceuticals, Inc. | Macrocyclic formulations for transmembrane drug delivery |
| CN100372522C (zh) * | 2005-12-02 | 2008-03-05 | 何秋莎 | 护肤品 |
| CA2578647A1 (en) * | 2007-02-15 | 2008-08-15 | University Of Saskatchewan | Reducing post-operative adhesion formation with intraperitoneal glutamine |
-
2011
- 2011-06-28 CA CA2804413A patent/CA2804413A1/en not_active Abandoned
- 2011-06-28 BR BR112012033349A patent/BR112012033349A2/pt not_active IP Right Cessation
- 2011-06-28 MX MX2013000107A patent/MX2013000107A/es not_active Application Discontinuation
- 2011-06-28 KR KR1020127034180A patent/KR20130089174A/ko not_active Withdrawn
- 2011-06-28 WO PCT/CA2011/050396 patent/WO2012000113A1/en not_active Ceased
- 2011-06-28 US US13/807,378 patent/US20140005116A1/en not_active Abandoned
- 2011-06-28 AU AU2011274224A patent/AU2011274224A1/en not_active Abandoned
- 2011-06-28 CN CN201180031168.3A patent/CN103002903B/zh active Active
- 2011-06-28 EP EP11800037.1A patent/EP2585090A4/en not_active Withdrawn
- 2011-06-28 RU RU2013103507/15A patent/RU2578426C2/ru active
- 2011-06-28 JP JP2013516930A patent/JP2013533867A/ja active Pending
-
2012
- 2012-12-21 ZA ZA2012/09759A patent/ZA201209759B/en unknown
-
2013
- 2013-01-28 CO CO13015329A patent/CO6680624A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2585090A1 (en) | 2013-05-01 |
| WO2012000113A1 (en) | 2012-01-05 |
| RU2013103507A (ru) | 2014-08-10 |
| ZA201209759B (en) | 2014-03-26 |
| CN103002903B (zh) | 2015-04-22 |
| EP2585090A4 (en) | 2014-01-15 |
| KR20130089174A (ko) | 2013-08-09 |
| JP2013533867A (ja) | 2013-08-29 |
| RU2578426C2 (ru) | 2016-03-27 |
| AU2011274224A8 (en) | 2014-09-18 |
| CN103002903A (zh) | 2013-03-27 |
| HK1183626A1 (en) | 2014-02-14 |
| CA2804413A1 (en) | 2012-01-05 |
| BR112012033349A2 (pt) | 2016-10-11 |
| MX2013000107A (es) | 2013-06-03 |
| US20140005116A1 (en) | 2014-01-02 |
| CO6680624A2 (es) | 2013-05-31 |
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