AU2011240752B2 - Methods and compositions for inhibition of Treg cells - Google Patents

Methods and compositions for inhibition of Treg cells Download PDF

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AU2011240752B2
AU2011240752B2 AU2011240752A AU2011240752A AU2011240752B2 AU 2011240752 B2 AU2011240752 B2 AU 2011240752B2 AU 2011240752 A AU2011240752 A AU 2011240752A AU 2011240752 A AU2011240752 A AU 2011240752A AU 2011240752 B2 AU2011240752 B2 AU 2011240752B2
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AU2011240752A1 (en
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Michael Har-Noy
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Immunovative Therapies Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/217IFN-gamma
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005Vertebrate antigens
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4262Heat shock proteins
    • AHUMAN NECESSITIES
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    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/428Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0637Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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    • A61K2035/122Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
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    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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    • AHUMAN NECESSITIES
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    • A61K2121/00Preparations for use in therapy
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1114T cells

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  • Developmental Biology & Embryology (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2011240752A 2010-04-13 2011-04-12 Methods and compositions for inhibition of Treg cells Active AU2011240752B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2016231642A AU2016231642B2 (en) 2010-04-13 2016-09-26 Methods and compositions for inhibition of treg cells
AU2018204834A AU2018204834B2 (en) 2010-04-13 2018-07-03 METHODS AND COMPOSITIONS FOR INHIBITION OF Treg CELLS

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US32355710P 2010-04-13 2010-04-13
US61/323,557 2010-04-13
PCT/US2011/032090 WO2011130249A2 (en) 2010-04-13 2011-04-12 Methods and compositions for inhibition of treg cells

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AU2011240752A1 AU2011240752A1 (en) 2012-11-08
AU2011240752B2 true AU2011240752B2 (en) 2016-07-28

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AU2018204834A Active AU2018204834B2 (en) 2010-04-13 2018-07-03 METHODS AND COMPOSITIONS FOR INHIBITION OF Treg CELLS

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US (2) US20110250173A1 (https=)
EP (1) EP2558123B1 (https=)
JP (2) JP6294666B2 (https=)
KR (3) KR20200063262A (https=)
CN (1) CN103002915B (https=)
AU (3) AU2011240752B2 (https=)
BR (1) BR112012026007A2 (https=)
CA (1) CA2796053A1 (https=)
IL (2) IL275017B2 (https=)
PH (1) PH12012502233A1 (https=)
SG (2) SG10201509539UA (https=)
WO (1) WO2011130249A2 (https=)

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CN103002915B (zh) * 2010-04-13 2015-09-23 免疫创新治疗有限公司 抑制Treg细胞的方法和组合物
BR112016015736B1 (pt) * 2014-01-08 2022-01-04 Immunovative Therapies, Ltd. Uso de um aloantígeno, uma molécula que interage com receptor de superfície cd40 e citocinas tipo i; e pelo menos um ou mais antígenos de hiv, kit, composição e composição de avi
TWI714529B (zh) * 2015-05-20 2021-01-01 以色列商梵提夫免疫療法公司 人類免疫缺乏病毒/後天性免疫缺乏症候群之治療
US11123404B2 (en) * 2016-01-07 2021-09-21 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Methods for generating immunotolerant responses
AU2017326173B2 (en) * 2016-09-16 2022-08-18 Baylor College Of Medicine Platform for activation and expansion of virus-specific T-cells
WO2021141473A1 (ko) 2020-01-10 2021-07-15 이뮤노바이옴 주식회사 신규한 락토바실러스 플란타룸 균주, 균주 유래 다당체 및 이의 용도
GB202007321D0 (en) * 2020-05-18 2020-07-01 Inst De Medicina Molecular Joaeo Lobo Antunes T cells

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US20030134415A1 (en) * 2001-09-19 2003-07-17 Gruenberg Micheal L. Th1 cell adoptive immunotherapy
US20040228848A1 (en) * 2003-05-13 2004-11-18 Michael Har-Noy Allogeneic cell therapy: mirror effect
US20080112963A1 (en) * 2006-11-13 2008-05-15 Immunovative Therapies, Ltd. Ablative immunotherapy
WO2009135199A2 (en) * 2008-05-02 2009-11-05 Immunovative Therapies, Ltd. Vaccine compositions and methods
US20100086561A1 (en) * 2008-10-01 2010-04-08 Immunovative Therapies Ltd. Th1 vaccination priming for active immunotherapy

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IL141868A0 (en) * 1998-10-05 2002-03-10 M & E Biotech As Novel methods for therapeutic vaccination
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US20050002951A1 (en) * 2001-09-28 2005-01-06 Haruo Sugiyama Novel method of inducing antigen-specific t cells
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AU2006214052A1 (en) * 2005-02-17 2006-08-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synergistic effect of TGF-beta blockade and immunogenic agents on tumors
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US20040228848A1 (en) * 2003-05-13 2004-11-18 Michael Har-Noy Allogeneic cell therapy: mirror effect
US20080112963A1 (en) * 2006-11-13 2008-05-15 Immunovative Therapies, Ltd. Ablative immunotherapy
WO2009135199A2 (en) * 2008-05-02 2009-11-05 Immunovative Therapies, Ltd. Vaccine compositions and methods
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Also Published As

Publication number Publication date
IL275017B2 (en) 2024-07-01
AU2016231642B2 (en) 2018-04-05
EP2558123A2 (en) 2013-02-20
EP2558123B1 (en) 2023-08-09
AU2018204834B2 (en) 2020-02-06
KR20130060188A (ko) 2013-06-07
AU2018204834A1 (en) 2018-08-02
SG184819A1 (en) 2012-11-29
EP2558123C0 (en) 2023-08-09
CA2796053A1 (en) 2011-10-20
AU2016231642A1 (en) 2016-10-27
BR112012026007A2 (pt) 2016-06-28
IL275017A (en) 2020-07-30
AU2011240752A1 (en) 2012-11-08
HK1184362A1 (en) 2014-01-24
KR20180123183A (ko) 2018-11-14
US20160361404A1 (en) 2016-12-15
IL222343A0 (en) 2012-12-31
CN103002915B (zh) 2015-09-23
CN103002915A (zh) 2013-03-27
JP2013523886A (ja) 2013-06-17
JP6294666B2 (ja) 2018-03-14
IL275017B1 (en) 2024-03-01
KR102117350B1 (ko) 2020-06-02
IL222343B (en) 2020-06-30
US20110250173A1 (en) 2011-10-13
SG10201509539UA (en) 2015-12-30
WO2011130249A3 (en) 2012-03-08
WO2011130249A2 (en) 2011-10-20
EP2558123A4 (en) 2014-03-19
PH12012502233A1 (en) 2022-10-05
JP2016155851A (ja) 2016-09-01
KR20200063262A (ko) 2020-06-04

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