AU2010346621B2 - Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens - Google Patents
Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens Download PDFInfo
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- AU2010346621B2 AU2010346621B2 AU2010346621A AU2010346621A AU2010346621B2 AU 2010346621 B2 AU2010346621 B2 AU 2010346621B2 AU 2010346621 A AU2010346621 A AU 2010346621A AU 2010346621 A AU2010346621 A AU 2010346621A AU 2010346621 B2 AU2010346621 B2 AU 2010346621B2
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| AU2010346621A AU2010346621B2 (en) | 2008-09-15 | 2010-03-17 | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
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| US12/210,344 | 2008-09-15 | ||
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| AU2009291552A AU2009291552B2 (en) | 2008-09-15 | 2009-09-14 | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
| US12/712,134 US8128951B2 (en) | 2008-09-15 | 2010-02-24 | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
| US12/712,134 | 2010-02-24 | ||
| PCT/US2010/027731 WO2011106027A1 (en) | 2010-02-24 | 2010-03-17 | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
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| AU2010346621A1 AU2010346621A1 (en) | 2012-09-06 |
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| NZ (1) | NZ601762A (enExample) |
| WO (1) | WO2011106027A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| KR20120106880A (ko) | 2007-01-21 | 2012-09-26 | 헤모텍 아게 | 체강의 협착 치료 및 급성 재협착 예방을 위한 의료 제품 |
| MX354603B (es) | 2007-05-25 | 2018-03-13 | Indivior Uk Ltd | Formulaciones de transferencia sostenida de compuestos de risperidona. |
| US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
| WO2010024898A2 (en) | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
| US9198968B2 (en) | 2008-09-15 | 2015-12-01 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
| US8257722B2 (en) * | 2008-09-15 | 2012-09-04 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
| US8114429B2 (en) | 2008-09-15 | 2012-02-14 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
| CA2792984A1 (en) * | 2009-04-22 | 2010-10-28 | Triomed Innovations Corp. | Method for coating an elastomeric material with a layer of antitoxic material |
| EP2451496B1 (en) | 2009-07-10 | 2015-07-22 | Boston Scientific Scimed, Inc. | Use of nanocrystals for a drug delivery balloon |
| WO2011008393A2 (en) | 2009-07-17 | 2011-01-20 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
| US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
| GB2481017B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
| WO2012031236A1 (en) | 2010-09-02 | 2012-03-08 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
| AU2012221758B2 (en) | 2011-02-24 | 2017-05-04 | Eximo Medical Ltd. | Hybrid catheter for tissue resection |
| US8669360B2 (en) | 2011-08-05 | 2014-03-11 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
| US9056152B2 (en) | 2011-08-25 | 2015-06-16 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
| US9956385B2 (en) | 2012-06-28 | 2018-05-01 | The Spectranetics Corporation | Post-processing of a medical device to control morphology and mechanical properties |
| US11883246B2 (en) | 2012-11-21 | 2024-01-30 | Trustees Of Boston University | Tissue markers and uses thereof |
| CN104174074B (zh) * | 2013-11-27 | 2016-05-18 | 浙江归创医疗器械有限公司 | 一种适用于涂在植入或介入医疗器械表面的药物涂层组合物 |
| US10525171B2 (en) * | 2014-01-24 | 2020-01-07 | The Spectranetics Corporation | Coatings for medical devices |
| GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
| CN106794043B (zh) | 2014-05-18 | 2020-03-13 | 爱克斯莫医疗有限公司 | 使用脉冲激光器进行组织消融的系统 |
| CN104056341B (zh) * | 2014-06-24 | 2017-01-18 | 深圳市金瑞凯利生物科技有限公司 | 药物球囊制备方法 |
| WO2016037413A1 (zh) * | 2014-09-09 | 2016-03-17 | 浙江归创医疗器械有限公司 | 一种药物涂层组合物、其制备方法及利用其制成的植入或介入医疗器械 |
| CA2974376A1 (en) * | 2015-01-22 | 2016-07-28 | Intersect Ent, Inc. | Drug-coated balloon |
| US11969567B2 (en) | 2015-11-18 | 2024-04-30 | Spectranetics Llc | Balloon angioplasty catheter coating to encourage vessel repair and further reduce restenosis |
| WO2017191644A1 (en) | 2016-05-05 | 2017-11-09 | Eximo Medical Ltd | Apparatus and methods for resecting and/or ablating an undesired tissue |
| DE102016110815B4 (de) * | 2016-06-13 | 2018-05-17 | Dot Gmbh | Beschichteter Ballonkatheter und Zusammensetzung zur Beschichtung des Ballonkatheters |
| JP7118061B2 (ja) * | 2016-12-22 | 2022-08-15 | バイオトロニック アクチェンゲゼルシャフト | 医療装置のための薬剤放出被膜およびその作製方法 |
| EP3796958A4 (en) * | 2018-05-04 | 2022-01-26 | Advanced Medical Solutions Israel (Sealantis) Ltd | Reconstitution and mixing systems |
| US10688289B2 (en) | 2018-06-12 | 2020-06-23 | Intersect Ent, Inc. | Systems and methods for sinus access |
| US12239371B2 (en) | 2018-08-09 | 2025-03-04 | Koninklijke Philips N.V. | Treatment mode selection systems and laser catheter systems including same |
| US11672959B2 (en) | 2019-01-18 | 2023-06-13 | Intersect Ent, Inc. | Expandable member systems and methods for drug delivery |
| EA202193001A1 (ru) | 2019-05-02 | 2022-02-08 | ИНТЕРСЕКТ ИЭнТи ИНТЕРНЭШНЛ ГМБХ | Устройство баллонной дилатации |
| US12376904B1 (en) | 2020-09-08 | 2025-08-05 | Angiodynamics, Inc. | Dynamic laser stabilization and calibration system |
| US11662126B2 (en) | 2021-06-17 | 2023-05-30 | Hewlett Packard Enterprise Development Lp | Leak mitigation system |
| US12038322B2 (en) | 2022-06-21 | 2024-07-16 | Eximo Medical Ltd. | Devices and methods for testing ablation systems |
| US20240408286A1 (en) * | 2023-06-08 | 2024-12-12 | Becton, Dickinson And Company | Tissue-plasminogen activator coated catheter with hydrogel-controlled elution |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090218731A1 (en) * | 1999-10-15 | 2009-09-03 | Rainer Rogasch | Shaped body and method for production of said body |
| US20090285974A1 (en) * | 2008-05-15 | 2009-11-19 | Kerrigan Cameron K | Method for electrostatic coating of a medical device |
| WO2010030995A2 (en) * | 2008-09-15 | 2010-03-18 | Cv Ingenuity | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
Family Cites Families (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4010259A (en) | 1975-07-17 | 1977-03-01 | Johansson J A Olof | Disinfectants containing iodine complexed to a hydrophilic organic carrier |
| US4589873A (en) | 1984-05-29 | 1986-05-20 | Becton, Dickinson And Company | Method of applying a hydrophilic coating to a polymeric substrate and articles prepared thereby |
| US5001009A (en) | 1987-09-02 | 1991-03-19 | Sterilization Technical Services, Inc. | Lubricious hydrophilic composite coated on substrates |
| US4950256A (en) | 1988-04-07 | 1990-08-21 | Luther Medical Products, Inc. | Non-thrombogenic intravascular time release catheter |
| US4847324A (en) | 1988-04-25 | 1989-07-11 | Hydromer, Inc. | Hydrophilic polyvinylbutyral alloys |
| US5328471A (en) | 1990-02-26 | 1994-07-12 | Endoluminal Therapeutics, Inc. | Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens |
| US6146358A (en) | 1989-03-14 | 2000-11-14 | Cordis Corporation | Method and apparatus for delivery of therapeutic agent |
| US5525348A (en) | 1989-11-02 | 1996-06-11 | Sts Biopolymers, Inc. | Coating compositions comprising pharmaceutical agents |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5674192A (en) | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
| US5302392A (en) | 1990-08-20 | 1994-04-12 | Becton, Dickinson And Company | Polyurethane sponge having rapid iodine release |
| JP3055796B2 (ja) | 1990-11-19 | 2000-06-26 | 善蔵 田村 | 殺菌消毒剤組成物 |
| US5762638A (en) | 1991-02-27 | 1998-06-09 | Shikani; Alain H. | Anti-infective and anti-inflammatory releasing systems for medical devices |
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5302394A (en) * | 1992-07-14 | 1994-04-12 | Mcneil-Ppc, Inc. | Dextromethorphan continuous lozenge manufacturing process |
| US6680050B1 (en) * | 1992-09-16 | 2004-01-20 | Triosyn Holdings, Inc. | Iodine/resin disinfectant and a procedure for the preparation thereof |
| US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| DE69320206T2 (de) | 1992-11-27 | 1999-02-11 | Napro Biotherapeutics Inc | Paclitaxel enthaltende injizierbare zusammensetzung |
| WO1994016706A1 (en) | 1993-01-28 | 1994-08-04 | Neorx Corporation | Therapeutic inhibitors of vascular smooth muscle cells |
| US6663881B2 (en) | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6096331A (en) | 1993-02-22 | 2000-08-01 | Vivorx Pharmaceuticals, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
| US6537579B1 (en) | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
| WO1994021308A1 (en) | 1993-03-18 | 1994-09-29 | Cedars-Sinai Medical Center | Drug incorporating and releasing polymeric coating for bioprosthesis |
| US5464650A (en) | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
| PT1155689E (pt) | 1993-07-19 | 2007-01-31 | Angiotech Pharm Inc | Composições anti-angiogenicas e metodos de utilização |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| PT1118325E (pt) | 1993-07-29 | 2006-05-31 | Us Health | Utilizacao de paclitaxel e seus derivados na preparacao de um medicamento para o tratamento de restenose |
| US5788979A (en) | 1994-07-22 | 1998-08-04 | Inflow Dynamics Inc. | Biodegradable coating with inhibitory properties for application to biocompatible materials |
| US5828084A (en) | 1995-03-27 | 1998-10-27 | Sony Corporation | High performance poly-SiGe thin film transistor |
| US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
| US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
| US6120784A (en) | 1996-02-20 | 2000-09-19 | Viro-Kote, Inc. | Anti-bacterial/anti-viral coatings, coating process and parameters thereof |
| JP2001507207A (ja) | 1996-05-01 | 2001-06-05 | イマアーレクス・フアーマシユーチカル・コーポレーシヨン | 化合物を細胞に送達する方法 |
| US20030157187A1 (en) | 1996-12-02 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating or preventing inflammatory diseases |
| US6491619B1 (en) * | 1997-01-31 | 2002-12-10 | Endologix, Inc | Radiation delivery catheters and dosimetry methods |
| US6159978A (en) | 1997-05-28 | 2000-12-12 | Aventis Pharmaceuticals Product, Inc. | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
| US6110483A (en) | 1997-06-23 | 2000-08-29 | Sts Biopolymers, Inc. | Adherent, flexible hydrogel and medicated coatings |
| US6306166B1 (en) | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
| JP2001514936A (ja) | 1997-08-13 | 2001-09-18 | ボストン サイエンティフィック コーポレイション | 水不溶性薬剤の装填および放出 |
| US8257725B2 (en) | 1997-09-26 | 2012-09-04 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
| US6369039B1 (en) | 1998-06-30 | 2002-04-09 | Scimed Life Sytems, Inc. | High efficiency local drug delivery |
| US6299604B1 (en) | 1998-08-20 | 2001-10-09 | Cook Incorporated | Coated implantable medical device |
| US20060240070A1 (en) | 1998-09-24 | 2006-10-26 | Cromack Keith R | Delivery of highly lipophilic agents via medical devices |
| US20050147690A1 (en) | 1998-09-25 | 2005-07-07 | Masters David B. | Biocompatible protein particles, particle devices and methods thereof |
| US6299980B1 (en) | 1998-09-29 | 2001-10-09 | Medtronic Ave, Inc. | One step lubricious coating |
| DE19858534A1 (de) | 1998-12-18 | 2000-06-21 | Bosch Gmbh Robert | Elektrischer Verbinder |
| US6419692B1 (en) | 1999-02-03 | 2002-07-16 | Scimed Life Systems, Inc. | Surface protection method for stents and balloon catheters for drug delivery |
| US6673053B2 (en) | 1999-05-07 | 2004-01-06 | Scimed Life Systems, Inc. | Hydrophilic lubricity coating for medical devices comprising an antiblock agent |
| JP4583756B2 (ja) | 2000-10-31 | 2010-11-17 | クック インコーポレイテッド | 医療器具 |
| US6545097B2 (en) | 2000-12-12 | 2003-04-08 | Scimed Life Systems, Inc. | Drug delivery compositions and medical devices containing block copolymer |
| GB0100760D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
| GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
| US7179251B2 (en) | 2001-01-17 | 2007-02-20 | Boston Scientific Scimed, Inc. | Therapeutic delivery balloon |
| US7771468B2 (en) | 2001-03-16 | 2010-08-10 | Angiotech Biocoatings Corp. | Medicated stent having multi-layer polymer coating |
| DE10115740A1 (de) | 2001-03-26 | 2002-10-02 | Ulrich Speck | Zubereitung für die Restenoseprophylaxe |
| US7879267B2 (en) | 2001-08-02 | 2011-02-01 | J&J Vision Care, Inc. | Method for coating articles by mold transfer |
| JP2005504070A (ja) | 2001-09-13 | 2005-02-10 | コリア・インスティテュート・オブ・サイエンス・アンド・テクノロジー | 化学塞栓用油性パクリタキセル組成物及び処方物並びにその製造方法 |
| EP1429819B1 (en) | 2001-09-24 | 2010-11-24 | Boston Scientific Limited | Optimized dosing for paclitaxel coated stents |
| US6753071B1 (en) | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
| US7488313B2 (en) | 2001-11-29 | 2009-02-10 | Boston Scientific Scimed, Inc. | Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment |
| US20030225451A1 (en) | 2002-01-14 | 2003-12-04 | Rangarajan Sundar | Stent delivery system, device, and method for coating |
| US7291165B2 (en) | 2002-01-31 | 2007-11-06 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
| US7008979B2 (en) | 2002-04-30 | 2006-03-07 | Hydromer, Inc. | Coating composition for multiple hydrophilic applications |
| US6835387B2 (en) | 2002-06-11 | 2004-12-28 | Scimed Life Systems, Inc. | Sustained release of superoxide dismutase mimics from implantable or insertable medical devices |
| US7105175B2 (en) | 2002-06-19 | 2006-09-12 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled delivery of a therapeutic agent |
| US20030236513A1 (en) | 2002-06-19 | 2003-12-25 | Scimed Life Systems, Inc. | Implantable or insertable medical devices for controlled delivery of a therapeutic agent |
| ATE495769T1 (de) | 2002-07-12 | 2011-02-15 | Cook Inc | Beschichtete medizinische vorrichtung |
| DE10244847A1 (de) | 2002-09-20 | 2004-04-01 | Ulrich Prof. Dr. Speck | Medizinische Vorrichtung zur Arzneimittelabgabe |
| US6926919B1 (en) | 2003-02-26 | 2005-08-09 | Advanced Cardiovascular Systems, Inc. | Method for fabricating a coating for a medical device |
| US8313759B2 (en) | 2003-03-06 | 2012-11-20 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices containing miscible polymer blends for controlled delivery of a therapeutic agent |
| US7241455B2 (en) | 2003-04-08 | 2007-07-10 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent |
| US7279174B2 (en) | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
| US7407507B2 (en) | 2003-06-18 | 2008-08-05 | Nipro Corporation | Balloon catheter suited to kissing techniques |
| US7790141B2 (en) * | 2003-08-11 | 2010-09-07 | Pathak Holdings, Llc | Radio-opaque compounds, compositions containing same and methods of their synthesis and use |
| US7736362B2 (en) | 2003-09-15 | 2010-06-15 | Boston Scientific Scimed, Inc. | Catheter balloons |
| US20050064223A1 (en) | 2003-09-22 | 2005-03-24 | Bavaro Vincent Peter | Polymeric marker with high radiopacity |
| US20100030183A1 (en) | 2004-03-19 | 2010-02-04 | Toner John L | Method of treating vascular disease at a bifurcated vessel using a coated balloon |
| US20060034769A1 (en) | 2004-08-13 | 2006-02-16 | Rutgers, The State University | Radiopaque polymeric stents |
| US20060212106A1 (en) | 2005-03-21 | 2006-09-21 | Jan Weber | Coatings for use on medical devices |
| EP1868663B1 (en) | 2005-03-23 | 2011-11-16 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
| US20070021282A1 (en) * | 2005-07-19 | 2007-01-25 | Karp Shaun A | Abdominal exercising and strength testing systems |
| ATE454908T1 (de) | 2005-09-21 | 2010-01-15 | Surmodics Inc | In situ okklusionszusammensetzungen mit natürlichen biologisch abbaubaren polysacchariden |
| WO2007040557A1 (en) | 2005-09-21 | 2007-04-12 | Surmodics, Inc. | Coatings and articles including natural biodegradable polysaccharides |
| US8137735B2 (en) | 2005-11-10 | 2012-03-20 | Allegiance Corporation | Elastomeric article with antimicrobial coating |
| JP5075131B2 (ja) | 2006-02-09 | 2012-11-14 | ビー．ブラウン メルズンゲン アーゲー | 折り畳まれたバルーンに被膜する方法 |
| US8021678B2 (en) | 2006-02-10 | 2011-09-20 | Advanced Cardiovascular Systems, Inc. | Implantable medical device with polymer coating in a surface area to volume ratio providing surface erosion characteristics |
| US8585753B2 (en) * | 2006-03-04 | 2013-11-19 | John James Scanlon | Fibrillated biodegradable prosthesis |
| US7875284B2 (en) | 2006-03-10 | 2011-01-25 | Cook Incorporated | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
| US7914806B2 (en) * | 2006-06-01 | 2011-03-29 | Boston Scientific Scimed, Inc. | Medical devices having improved performance |
| US20080124372A1 (en) | 2006-06-06 | 2008-05-29 | Hossainy Syed F A | Morphology profiles for control of agent release rates from polymer matrices |
| CA2656635C (en) * | 2006-07-03 | 2013-05-28 | Hemoteq Ag | Stent with polymeric coating comprising rapamycin as an active agent |
| EP2061526B1 (en) * | 2006-09-13 | 2015-07-29 | DSM IP Assets B.V. | Coated medical device |
| US8561614B2 (en) | 2006-09-28 | 2013-10-22 | Covidien Lp | Multi-layer cuffs for medical devices |
| US8414909B2 (en) * | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US20080140002A1 (en) | 2006-12-06 | 2008-06-12 | Kamal Ramzipoor | System for delivery of biologically active substances with actuating three dimensional surface |
| US20080146489A1 (en) | 2006-12-15 | 2008-06-19 | Pacetti Stephen D | Regional delivery of therapeutic agents for the treatment of vascular diseases |
| EP2125061A2 (en) * | 2007-02-28 | 2009-12-02 | DSM IP Assets B.V. | Hydrophilic coating |
| EP2200674A2 (en) | 2007-09-10 | 2010-06-30 | Boston Scientific Scimed, Inc. | Medical devices with triggerable bioadhesive material |
| US20090112239A1 (en) | 2007-10-31 | 2009-04-30 | Specialized Vascular Technologies, Inc. | Sticky dilatation balloon and methods of using |
| US20090186414A1 (en) | 2008-01-18 | 2009-07-23 | Deepak Srivastava | Methods of Generating Cardiomyocytes and Cardiac Progenitors and Compositions |
| US20090226502A1 (en) | 2008-03-06 | 2009-09-10 | Boston Scientific Scimed, Inc. | Balloon catheter devices with solvent-swellable polymer |
| US20090297584A1 (en) | 2008-04-18 | 2009-12-03 | Florencia Lim | Biosoluble coating with linear over time mass loss |
| EP2313122B1 (en) | 2008-07-17 | 2019-03-06 | Micell Technologies, Inc. | Drug delivery medical device |
| US8367090B2 (en) | 2008-09-05 | 2013-02-05 | Abbott Cardiovascular Systems Inc. | Coating on a balloon comprising a polymer and a drug |
| DE102008044316A1 (de) | 2008-12-03 | 2010-06-10 | Biotronik Vi Patent Ag | Wirkstoffbeschichtetes Medizinprodukt, Verfahren zu dessen Herstellung und dessen Verwendungen |
| CA2792984A1 (en) * | 2009-04-22 | 2010-10-28 | Triomed Innovations Corp. | Method for coating an elastomeric material with a layer of antitoxic material |
-
2010
- 2010-02-24 US US12/712,134 patent/US8128951B2/en active Active
- 2010-03-17 CA CA2789565A patent/CA2789565A1/en not_active Abandoned
- 2010-03-17 CN CN2010800644973A patent/CN102781489A/zh active Pending
- 2010-03-17 WO PCT/US2010/027731 patent/WO2011106027A1/en not_active Ceased
- 2010-03-17 AU AU2010346621A patent/AU2010346621B2/en not_active Ceased
- 2010-03-17 CN CN201610050061.8A patent/CN105664263A/zh active Pending
- 2010-03-17 NZ NZ601762A patent/NZ601762A/en not_active IP Right Cessation
- 2010-03-17 EP EP10716921.1A patent/EP2538990B1/en active Active
- 2010-03-17 JP JP2012554976A patent/JP5781548B2/ja active Active
-
2011
- 2011-12-02 US US13/310,320 patent/US8563023B2/en active Active
-
2013
- 2013-09-20 US US14/032,336 patent/US20140171864A1/en not_active Abandoned
-
2014
- 2014-04-17 AU AU2014202149A patent/AU2014202149B2/en not_active Ceased
- 2014-07-10 JP JP2014142111A patent/JP2014195736A/ja not_active Withdrawn
-
2016
- 2016-07-06 JP JP2016133994A patent/JP6169229B2/ja active Active
- 2016-07-06 HK HK16107852.4A patent/HK1219908A1/zh unknown
- 2016-08-05 AU AU2016210749A patent/AU2016210749B2/en not_active Ceased
-
2017
- 2017-06-28 JP JP2017125830A patent/JP6466520B2/ja active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090218731A1 (en) * | 1999-10-15 | 2009-09-03 | Rainer Rogasch | Shaped body and method for production of said body |
| US20090285974A1 (en) * | 2008-05-15 | 2009-11-19 | Kerrigan Cameron K | Method for electrostatic coating of a medical device |
| WO2010030995A2 (en) * | 2008-09-15 | 2010-03-18 | Cv Ingenuity | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
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| JP6169229B2 (ja) | 2017-07-26 |
| CN105664263A (zh) | 2016-06-15 |
| US20100198190A1 (en) | 2010-08-05 |
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