AU2010306559B2 - Recombinant modified vaccinia Ankara (MVA) vaccinia virus containing restructured insertion sites - Google Patents
Recombinant modified vaccinia Ankara (MVA) vaccinia virus containing restructured insertion sites Download PDFInfo
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- AU2010306559B2 AU2010306559B2 AU2010306559A AU2010306559A AU2010306559B2 AU 2010306559 B2 AU2010306559 B2 AU 2010306559B2 AU 2010306559 A AU2010306559 A AU 2010306559A AU 2010306559 A AU2010306559 A AU 2010306559A AU 2010306559 B2 AU2010306559 B2 AU 2010306559B2
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/863—Poxviral vectors, e.g. entomopoxvirus
- C12N15/8636—Vaccina virus vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A61K2039/5256—Virus expressing foreign proteins
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
- A61K39/285—Vaccinia virus or variola virus
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24133—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24151—Methods of production or purification of viral material
- C12N2710/24152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25232609P | 2009-10-16 | 2009-10-16 | |
| US61/252,326 | 2009-10-16 | ||
| PCT/US2010/052929 WO2011047324A1 (en) | 2009-10-16 | 2010-10-15 | Recombinant modified vaccinia ankara (mva) vaccinia virus containing restructured insertion sites |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2010306559A1 AU2010306559A1 (en) | 2012-06-07 |
| AU2010306559B2 true AU2010306559B2 (en) | 2015-07-16 |
Family
ID=43297031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010306559A Active AU2010306559B2 (en) | 2009-10-16 | 2010-10-15 | Recombinant modified vaccinia Ankara (MVA) vaccinia virus containing restructured insertion sites |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9133480B2 (OSRAM) |
| EP (1) | EP2488649B1 (OSRAM) |
| JP (1) | JP5789263B2 (OSRAM) |
| AU (1) | AU2010306559B2 (OSRAM) |
| CA (1) | CA2777744C (OSRAM) |
| DK (1) | DK2488649T3 (OSRAM) |
| WO (1) | WO2011047324A1 (OSRAM) |
| ZA (1) | ZA201203551B (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008142479A2 (en) * | 2006-08-25 | 2008-11-27 | The Government Of The United States Of Amercia, As Represented By The Secretary, Department Of Health And Human Services | Intergenic sites between conserved genes in the genome of modified vaccinia ankara (mva) vaccinia virus |
| US8580276B2 (en) | 2009-06-05 | 2013-11-12 | City Of Hope | Genetically stable recombinant modified vaccinia ankara (rMVA) vaccines and methods of preparation thereof |
| EP2488649B1 (en) | 2009-10-16 | 2019-04-03 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Recombinant modified vaccinia ankara (mva) vaccinia virus containing restructured insertion sites |
| EP2620446A1 (en) | 2012-01-27 | 2013-07-31 | Laboratorios Del Dr. Esteve, S.A. | Immunogens for HIV vaccination |
| US10894966B2 (en) | 2014-09-26 | 2021-01-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Virus-based expression vectors and uses thereof |
| US11701418B2 (en) | 2015-01-12 | 2023-07-18 | Geovax, Inc. | Replication-deficient modified vaccinia Ankara (MVA) expressing Ebola virus glycoprotein (GP) and matrix protein (VP40) |
| US20190038659A1 (en) | 2015-09-29 | 2019-02-07 | The Usa, As Represented By The Secretary, Department Of Health And Human Services | Methods of treating and preventing amyotrophic lateral sclerosis |
| AU2017206102C1 (en) | 2016-01-08 | 2022-02-10 | Geovax Inc. | Compositions and methods for generating an immune response to a tumor associated antigen |
| US20190030157A1 (en) | 2016-02-03 | 2019-01-31 | Geovax Inc. | Compositions and Methods for Generating an Immune Response to a Flavivirus |
| US11052148B2 (en) * | 2016-05-30 | 2021-07-06 | Geo Vax, Inc. | Compositions and methods for generating an immune response to hepatitis B virus |
| US11311612B2 (en) | 2017-09-19 | 2022-04-26 | Geovax, Inc. | Compositions and methods for generating an immune response to treat or prevent malaria |
| WO2019152746A2 (en) | 2018-01-30 | 2019-08-08 | Emory University | Compositions and methods for promoting immune responses to human immunodeficiency virus |
| CN112512568A (zh) | 2018-05-11 | 2021-03-16 | 希望之城 | 遗传修饰的重组痘苗安卡拉(rmva)疫苗改善的稳定性及其制备方法 |
| WO2021066612A2 (ko) * | 2019-10-02 | 2021-04-08 | 주식회사 바이오녹스 | 종양 표적화 단백질 또는 이의 단편 및 그것에 결합하는 항체 및 이의 용도 |
| AU2020384323A1 (en) | 2019-11-14 | 2022-06-02 | Aelix Therapeutics, S.L. | Dosage regimens for vaccines |
| AU2022215566A1 (en) | 2021-02-02 | 2023-08-17 | Geovax, Inc. | Viral constructs for use in enhancing t-cell priming during vaccination |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008142479A2 (en) * | 2006-08-25 | 2008-11-27 | The Government Of The United States Of Amercia, As Represented By The Secretary, Department Of Health And Human Services | Intergenic sites between conserved genes in the genome of modified vaccinia ankara (mva) vaccinia virus |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL218318B1 (pl) | 2002-05-16 | 2014-11-28 | Bavarian Nordic As | Rekombinowany wirus krowianki Ankara (MVA), zawierająca go komórka, szczepionka lub kompozycja farmaceutyczna, sposób lub zestaw do jego otrzymywania, sekwencja DNA zawierająca genom tego wirusa oraz sposób wykrywania tego wirusa lub komórek nim zainfekowanych |
| EP2359851A3 (en) | 2003-03-28 | 2011-08-31 | The Government of the United States of America, represented by The Secretary, Department of Health and Human Services | MVA expressing modified hiv envelope, gag, and pol genes |
| EP2199400A1 (en) | 2008-12-22 | 2010-06-23 | Emergent Product Development Germany GmbH | Single recombination system and methods of use |
| EP2488649B1 (en) | 2009-10-16 | 2019-04-03 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Recombinant modified vaccinia ankara (mva) vaccinia virus containing restructured insertion sites |
-
2010
- 2010-10-15 EP EP10771611.0A patent/EP2488649B1/en active Active
- 2010-10-15 AU AU2010306559A patent/AU2010306559B2/en active Active
- 2010-10-15 US US13/502,205 patent/US9133480B2/en active Active
- 2010-10-15 JP JP2012534414A patent/JP5789263B2/ja active Active
- 2010-10-15 DK DK10771611.0T patent/DK2488649T3/da active
- 2010-10-15 CA CA2777744A patent/CA2777744C/en active Active
- 2010-10-15 WO PCT/US2010/052929 patent/WO2011047324A1/en not_active Ceased
-
2012
- 2012-05-15 ZA ZA2012/03551A patent/ZA201203551B/en unknown
-
2015
- 2015-08-27 US US14/837,382 patent/US9879231B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008142479A2 (en) * | 2006-08-25 | 2008-11-27 | The Government Of The United States Of Amercia, As Represented By The Secretary, Department Of Health And Human Services | Intergenic sites between conserved genes in the genome of modified vaccinia ankara (mva) vaccinia virus |
Non-Patent Citations (2)
| Title |
|---|
| EARL, P.L. et al. Virology, 2007, Vol.366, p.84-97 * |
| TIMM, A. et al. Vaccine, 2006, Vol.24, p.4618-4621 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010306559A1 (en) | 2012-06-07 |
| ZA201203551B (en) | 2013-01-30 |
| US9879231B2 (en) | 2018-01-30 |
| WO2011047324A1 (en) | 2011-04-21 |
| DK2488649T3 (da) | 2019-06-17 |
| US20120263750A1 (en) | 2012-10-18 |
| JP2013507935A (ja) | 2013-03-07 |
| EP2488649B1 (en) | 2019-04-03 |
| CA2777744C (en) | 2019-09-24 |
| CA2777744A1 (en) | 2011-04-21 |
| EP2488649A1 (en) | 2012-08-22 |
| US20160040135A1 (en) | 2016-02-11 |
| US9133480B2 (en) | 2015-09-15 |
| JP5789263B2 (ja) | 2015-10-07 |
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| FGA | Letters patent sealed or granted (standard patent) |