AU2010272957B2 - Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines - Google Patents

Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines Download PDF

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Publication number
AU2010272957B2
AU2010272957B2 AU2010272957A AU2010272957A AU2010272957B2 AU 2010272957 B2 AU2010272957 B2 AU 2010272957B2 AU 2010272957 A AU2010272957 A AU 2010272957A AU 2010272957 A AU2010272957 A AU 2010272957A AU 2010272957 B2 AU2010272957 B2 AU 2010272957B2
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AU
Australia
Prior art keywords
group
hydroxyquinoline
ionophore
acid
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010272957A
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English (en)
Other versions
AU2010272957A1 (en
Inventor
Thomas Lars Andresen
Palle Hedengran Rasmussen
Andreas Kjaer
Anncatrine Luisa Petersen
Jonas Rosager Henriksen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rigshospitalet
Danmarks Tekniske Universitet
Original Assignee
Rigshospitalet
Danmarks Tekniske Universitet
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Filing date
Publication date
Application filed by Rigshospitalet, Danmarks Tekniske Universitet filed Critical Rigshospitalet
Publication of AU2010272957A1 publication Critical patent/AU2010272957A1/en
Application granted granted Critical
Publication of AU2010272957B2 publication Critical patent/AU2010272957B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/025—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus inorganic Tc complexes or compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1234—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AU2010272957A 2009-07-17 2010-07-16 Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines Ceased AU2010272957B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DKPA200900879 2009-07-17
DKPA200900879 2009-07-17
US30078210P 2010-02-02 2010-02-02
EP10152394 2010-02-02
EP10152394.2 2010-02-02
US61/300,782 2010-02-02
PCT/DK2010/050192 WO2011006510A1 (en) 2009-07-17 2010-07-16 Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines

Publications (2)

Publication Number Publication Date
AU2010272957A1 AU2010272957A1 (en) 2012-03-08
AU2010272957B2 true AU2010272957B2 (en) 2016-03-03

Family

ID=43448962

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010272957A Ceased AU2010272957B2 (en) 2009-07-17 2010-07-16 Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines

Country Status (7)

Country Link
US (2) US8920775B2 (https=)
EP (1) EP2453927B1 (https=)
JP (1) JP5872466B2 (https=)
AU (1) AU2010272957B2 (https=)
CA (1) CA2768444A1 (https=)
IN (1) IN2012DN01449A (https=)
WO (1) WO2011006510A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5947807B2 (ja) 2010-12-14 2016-07-06 テクニカル ユニバーシティ オブ デンマークＴｅｃｈｎｉｃａｌ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｄｅｎｍａｒｋ ナノ粒子組成物への放射性核種の封入
KR20150050524A (ko) 2012-04-17 2015-05-08 메리맥 파마슈티컬즈, 인크. 비침습적 이미징을 위한 조성물 및 방법
US9480759B2 (en) * 2012-11-21 2016-11-01 Serene, Llc Tin-117m somatostatin receptor binding compounds and methods
EP2968150B1 (en) * 2013-03-11 2020-08-19 Wayne State University Liposomes comprising europium cryptands and their use
US10781178B2 (en) 2015-08-12 2020-09-22 The General Hospital Corporation 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents
CA3015663A1 (en) * 2016-03-07 2017-09-14 Memorial Sloan Kettering Cancer Center Bone marrow-, reticuloendothelial system-, and/or lymph node-targeted radiolabeled liposomes and methods of their diagnostic and therapeutic use
US20220023450A1 (en) * 2018-09-11 2022-01-27 Memorial Sloan Kettering Cancer Center Bone marrow-, reticuloendothelial system-, and/or lymph node-targeted radiolabeled liposomes and methods of their diagnostic and therapeutic use
US11478493B2 (en) * 2019-03-08 2022-10-25 University Of South Carolina Fabrication and application of a hetero-targeted nano-cocktail with traceless linkers
KR20230173150A (ko) 2021-04-20 2023-12-26 테라파워, 엘엘씨 Ac-225 생성용 티타니아 기반 발생기
CA3258344A1 (en) 2022-06-07 2023-12-14 Actinium Pharmaceuticals, Inc. CHELETARIANS AND BIFUNCTIONAL CONJUGATES

Citations (5)

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Publication number Priority date Publication date Assignee Title
US5213804A (en) * 1989-10-20 1993-05-25 Liposome Technology, Inc. Solid tumor treatment method and composition
WO2001060417A2 (en) * 2000-02-21 2001-08-23 Anticancer Therapeutic Inventions As Radioactive therapeutic liposomes
WO2004082627A2 (en) * 2003-03-18 2004-09-30 Ethicon, Inc. ENZYME REPLACEMENT THERAPY WITH 17-β-HYDROXYSTEROID DEHYDROGENASE-TYPE 2
WO2004082626A2 (en) * 2003-03-18 2004-09-30 Ethicon, Inc. Aromatase inhibitor diagnosis and therapy
WO2006043083A2 (en) * 2004-10-22 2006-04-27 Algeta As Liposomes enclosing a radionuclide and a cytotoxic agent for combination therapy

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CA1314209C (en) 1987-11-04 1993-03-09 Gary Fujii Composition and method for use for liposome encapsulated compounds for neutron capture tumor therapy
US5688488A (en) 1989-04-03 1997-11-18 Purdue Research Foundation Composition and method for tumor imaging
US5525232A (en) * 1990-03-02 1996-06-11 The Liposome Company, Inc. Method for entrapment of cationic species in lemellar vesicles
JPH075561B2 (ja) 1991-12-17 1995-01-25 工業技術院長 α−アミノ酸のジアミド誘導体
US5837282A (en) * 1996-10-30 1998-11-17 University Of British Columbia Ionophore-mediated liposome loading
US6306393B1 (en) * 1997-03-24 2001-10-23 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
US5945502A (en) * 1997-11-13 1999-08-31 Xerox Corporation Electroluminescent polymer compositions and processes thereof
DE10012782A1 (de) * 2000-03-16 2001-09-20 Boellhoff Gmbh Verbindungsanordnung zum Anbringen eines Befestigungselementes an einem Bauteil
WO2006021008A2 (en) 2004-08-20 2006-02-23 Lind Stuart E Ionophores as cancer chemotherapeutic agents
WO2006037230A1 (en) * 2004-10-06 2006-04-13 Bc Cancer Agency Liposomes with improved drug retention for treatment of cancer
ITMI20050328A1 (it) 2005-03-03 2006-09-04 Univ Degli Studi Milano Composti peptidomimetrici e preparazione di derivati biologicamente attivi
CA2648099C (en) * 2006-03-31 2012-05-29 The Brigham And Women's Hospital, Inc System for targeted delivery of therapeutic agents
TW200922630A (en) * 2007-09-26 2009-06-01 Nat Health Research Institutes Liposome compositions useful for tumor imaging and treatment
WO2009140215A2 (en) 2008-05-11 2009-11-19 Geraghty, Erin Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds
CN104023793B (zh) * 2011-10-31 2017-11-24 马林克罗特有限公司 用于治疗癌症的联合脂质体组合物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5213804A (en) * 1989-10-20 1993-05-25 Liposome Technology, Inc. Solid tumor treatment method and composition
WO2001060417A2 (en) * 2000-02-21 2001-08-23 Anticancer Therapeutic Inventions As Radioactive therapeutic liposomes
WO2004082627A2 (en) * 2003-03-18 2004-09-30 Ethicon, Inc. ENZYME REPLACEMENT THERAPY WITH 17-β-HYDROXYSTEROID DEHYDROGENASE-TYPE 2
WO2004082626A2 (en) * 2003-03-18 2004-09-30 Ethicon, Inc. Aromatase inhibitor diagnosis and therapy
WO2006043083A2 (en) * 2004-10-22 2006-04-27 Algeta As Liposomes enclosing a radionuclide and a cytotoxic agent for combination therapy

Also Published As

Publication number Publication date
JP5872466B2 (ja) 2016-03-01
EP2453927A1 (en) 2012-05-23
CA2768444A1 (en) 2011-01-20
EP2453927A4 (en) 2013-01-23
US20120213698A1 (en) 2012-08-23
EP2453927B1 (en) 2019-05-15
IN2012DN01449A (https=) 2015-06-05
JP2012533523A (ja) 2012-12-27
US20150202336A1 (en) 2015-07-23
US8920775B2 (en) 2014-12-30
WO2011006510A1 (en) 2011-01-20
AU2010272957A1 (en) 2012-03-08

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired