AU2010272957B2 - Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines - Google Patents

Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines Download PDF

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Publication number
AU2010272957B2
AU2010272957B2 AU2010272957A AU2010272957A AU2010272957B2 AU 2010272957 B2 AU2010272957 B2 AU 2010272957B2 AU 2010272957 A AU2010272957 A AU 2010272957A AU 2010272957 A AU2010272957 A AU 2010272957A AU 2010272957 B2 AU2010272957 B2 AU 2010272957B2
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AU
Australia
Prior art keywords
group
hydroxyquinoline
ionophore
acid
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010272957A
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English (en)
Other versions
AU2010272957A1 (en
Inventor
Thomas Lars Andresen
Palle Hedengran Rasmussen
Andreas Kjaer
Anncatrine Luisa Petersen
Jonas Rosager Henriksen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rigshospitalet
Danmarks Tekniske Universitet
Original Assignee
Rigshospitalet
Danmarks Tekniske Universitet
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Publication date
Application filed by Rigshospitalet, Danmarks Tekniske Universitet filed Critical Rigshospitalet
Publication of AU2010272957A1 publication Critical patent/AU2010272957A1/en
Application granted granted Critical
Publication of AU2010272957B2 publication Critical patent/AU2010272957B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/025—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus inorganic Tc complexes or compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1234—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AU2010272957A 2009-07-17 2010-07-16 Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines Ceased AU2010272957B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DKPA200900879 2009-07-17
DKPA200900879 2009-07-17
US30078210P 2010-02-02 2010-02-02
US61/300,782 2010-02-02
EP10152394.2 2010-02-02
EP10152394 2010-02-02
PCT/DK2010/050192 WO2011006510A1 (en) 2009-07-17 2010-07-16 Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines

Publications (2)

Publication Number Publication Date
AU2010272957A1 AU2010272957A1 (en) 2012-03-08
AU2010272957B2 true AU2010272957B2 (en) 2016-03-03

Family

ID=43448962

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010272957A Ceased AU2010272957B2 (en) 2009-07-17 2010-07-16 Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines

Country Status (7)

Country Link
US (2) US8920775B2 (https=)
EP (1) EP2453927B1 (https=)
JP (1) JP5872466B2 (https=)
AU (1) AU2010272957B2 (https=)
CA (1) CA2768444A1 (https=)
IN (1) IN2012DN01449A (https=)
WO (1) WO2011006510A1 (https=)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
KR20140092226A (ko) 2010-12-14 2014-07-23 테크니칼 유니버시티 오브 덴마크 나노입자 조성물에서 방사성 핵종의 포집
AU2013249307B2 (en) * 2012-04-17 2017-11-09 Merrimack Pharmaceuticals, Inc. Compositions and methods for non-invasive imaging
EP2922578B1 (en) * 2012-11-21 2018-12-12 Serene, Llc Tin-117m comprising somatostatin receptor binding compounds
US20160022842A1 (en) * 2013-03-11 2016-01-28 Wayne State University Formation and uses of europium
US10781178B2 (en) 2015-08-12 2020-09-22 The General Hospital Corporation 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents
JP2019512484A (ja) * 2016-03-07 2019-05-16 メモリアル スローン ケタリング キャンサー センター 骨髄、細網内皮系、および／またはリンパ節を標的にする放射標識リポソームならびにその診断用および治療用使用の方法
WO2020055929A1 (en) * 2018-09-11 2020-03-19 Memorial Sloan Kettering Cancer Center Bone marrow-, reticuloendothelial system-, and/or lymph node-targeted radiolabeled liposomes and methods of their diagnostic and therapeutic use
US11478493B2 (en) * 2019-03-08 2022-10-25 University Of South Carolina Fabrication and application of a hetero-targeted nano-cocktail with traceless linkers
JP2024515104A (ja) 2021-04-20 2024-04-04 テラパワー， エルエルシー Ａｃ－２２５生成のためのチタニアに基づくジェネレータ
EP4536278A2 (en) 2022-06-07 2025-04-16 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates

Citations (5)

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US5213804A (en) * 1989-10-20 1993-05-25 Liposome Technology, Inc. Solid tumor treatment method and composition
WO2001060417A2 (en) * 2000-02-21 2001-08-23 Anticancer Therapeutic Inventions As Radioactive therapeutic liposomes
WO2004082627A2 (en) * 2003-03-18 2004-09-30 Ethicon, Inc. ENZYME REPLACEMENT THERAPY WITH 17-β-HYDROXYSTEROID DEHYDROGENASE-TYPE 2
WO2004082626A2 (en) * 2003-03-18 2004-09-30 Ethicon, Inc. Aromatase inhibitor diagnosis and therapy
WO2006043083A2 (en) * 2004-10-22 2006-04-27 Algeta As Liposomes enclosing a radionuclide and a cytotoxic agent for combination therapy

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ATE88642T1 (de) 1987-11-04 1993-05-15 Vestar Inc Zusammensetzung und verfahren zur anwendung von in liposomen eingeschlossenen verbindungen in der neutroneneinfangtherapie von tumoren.
US5688488A (en) 1989-04-03 1997-11-18 Purdue Research Foundation Composition and method for tumor imaging
US5525232A (en) * 1990-03-02 1996-06-11 The Liposome Company, Inc. Method for entrapment of cationic species in lemellar vesicles
JPH075561B2 (ja) * 1991-12-17 1995-01-25 工業技術院長 α−アミノ酸のジアミド誘導体
US5837282A (en) * 1996-10-30 1998-11-17 University Of British Columbia Ionophore-mediated liposome loading
US6306393B1 (en) * 1997-03-24 2001-10-23 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
US5945502A (en) * 1997-11-13 1999-08-31 Xerox Corporation Electroluminescent polymer compositions and processes thereof
DE10012782A1 (de) * 2000-03-16 2001-09-20 Boellhoff Gmbh Verbindungsanordnung zum Anbringen eines Befestigungselementes an einem Bauteil
US20060040980A1 (en) 2004-08-20 2006-02-23 Lind Stuart E Ionophores as cancer chemotherapeutic agents
BRPI0516265A (pt) * 2004-10-06 2008-08-26 Bc Cancer Agency composição, uso da mesma, método de aumentar a retenção de um agente terapêutico dentro dos lipossomas, formulação lipossomal, e, uso de um agente terapêutico encapsulado lipossomalmente
ITMI20050328A1 (it) 2005-03-03 2006-09-04 Univ Degli Studi Milano Composti peptidomimetrici e preparazione di derivati biologicamente attivi
ES2776100T3 (es) * 2006-03-31 2020-07-29 Massachusetts Inst Technology Sistema para el suministro dirigido de agentes terapéuticos
TW200922630A (en) * 2007-09-26 2009-06-01 Nat Health Research Institutes Liposome compositions useful for tumor imaging and treatment
WO2009140215A2 (en) * 2008-05-11 2009-11-19 Geraghty, Erin Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds
WO2013066903A1 (en) * 2011-10-31 2013-05-10 Mallinckrodt Llc Combinational liposome compositions for cancer therapy

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5213804A (en) * 1989-10-20 1993-05-25 Liposome Technology, Inc. Solid tumor treatment method and composition
WO2001060417A2 (en) * 2000-02-21 2001-08-23 Anticancer Therapeutic Inventions As Radioactive therapeutic liposomes
WO2004082627A2 (en) * 2003-03-18 2004-09-30 Ethicon, Inc. ENZYME REPLACEMENT THERAPY WITH 17-β-HYDROXYSTEROID DEHYDROGENASE-TYPE 2
WO2004082626A2 (en) * 2003-03-18 2004-09-30 Ethicon, Inc. Aromatase inhibitor diagnosis and therapy
WO2006043083A2 (en) * 2004-10-22 2006-04-27 Algeta As Liposomes enclosing a radionuclide and a cytotoxic agent for combination therapy

Also Published As

Publication number Publication date
EP2453927A4 (en) 2013-01-23
US20150202336A1 (en) 2015-07-23
US20120213698A1 (en) 2012-08-23
US8920775B2 (en) 2014-12-30
IN2012DN01449A (https=) 2015-06-05
EP2453927A1 (en) 2012-05-23
CA2768444A1 (en) 2011-01-20
JP5872466B2 (ja) 2016-03-01
JP2012533523A (ja) 2012-12-27
WO2011006510A1 (en) 2011-01-20
EP2453927B1 (en) 2019-05-15
AU2010272957A1 (en) 2012-03-08

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired