AU2010219466A1

AU2010219466A1 - Pyrrolopyrimidines used as kinase inhibitors

Pyrrolopyrimidines used as kinase inhibitors Download PDF

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Publication number: AU2010219466A1
Authority: AU; Australia
Prior art keywords: propyl; amide; pyrimidin; pyrrolo; alkyl
Prior art date: 2009-03-04
Legal status : Abandoned

Application number

AU2010219466A

Other languages

English (en)

Inventor

Joane Hough

Edward Giles Mciver

Current Assignee

LifeArc

Original Assignee

Medical Research Council Technology

Priority date

2009-03-04

Filing date

2010-03-04

Publication date

2011-09-01

2010-03-04 Application filed by Medical Research Council Technology filed Critical Medical Research Council Technology

2011-09-01 Publication of AU2010219466A1 publication Critical patent/AU2010219466A1/en

Status Abandoned legal-status Critical Current

Links

150000004944 pyrrolopyrimidines Chemical class 0.000 title description 4
229940043355 kinase inhibitor Drugs 0.000 title description 2
239000003757 phosphotransferase inhibitor Substances 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 194
-1 VEG-FR Proteins 0.000 claims abstract description 136
108091000080 Phosphotransferase Proteins 0.000 claims abstract description 58
102000020233 phosphotransferase Human genes 0.000 claims abstract description 58
238000000034 method Methods 0.000 claims abstract description 57
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 53
101000665442 Homo sapiens Serine/threonine-protein kinase TBK1 Proteins 0.000 claims abstract description 51
102100038192 Serine/threonine-protein kinase TBK1 Human genes 0.000 claims abstract description 51
125000001072 heteroaryl group Chemical group 0.000 claims abstract description 39
206010030348 Open-Angle Glaucoma Diseases 0.000 claims abstract description 38
201000006366 primary open angle glaucoma Diseases 0.000 claims abstract description 38
125000003118 aryl group Chemical group 0.000 claims abstract description 30
208000035475 disorder Diseases 0.000 claims abstract description 27
239000003814 drug Substances 0.000 claims abstract description 26
102000001284 I-kappa-B kinase Human genes 0.000 claims abstract description 23
108060006678 I-kappa-B kinase Proteins 0.000 claims abstract description 23
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 23
101001059429 Homo sapiens MAP/microtubule affinity-regulating kinase 3 Proteins 0.000 claims abstract description 22
102100028920 MAP/microtubule affinity-regulating kinase 3 Human genes 0.000 claims abstract description 22
229910052736 halogen Inorganic materials 0.000 claims abstract description 22
150000002367 halogens Chemical class 0.000 claims abstract description 22
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 22
125000000592 heterocycloalkyl group Chemical group 0.000 claims abstract description 21
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238000002360 preparation method Methods 0.000 claims abstract description 17
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