AU2009326261B2 - Compounds for use in the treatment of pain - Google Patents

Compounds for use in the treatment of pain Download PDF

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Publication number
AU2009326261B2
AU2009326261B2 AU2009326261A AU2009326261A AU2009326261B2 AU 2009326261 B2 AU2009326261 B2 AU 2009326261B2 AU 2009326261 A AU2009326261 A AU 2009326261A AU 2009326261 A AU2009326261 A AU 2009326261A AU 2009326261 B2 AU2009326261 B2 AU 2009326261B2
Authority
AU
Australia
Prior art keywords
compound
pain
propofol
substituted
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009326261A
Other languages
English (en)
Other versions
AU2009326261A1 (en
Inventor
Neil Berry
Gertrud Haeseler
Martin Leuwer
Paul O'neill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Dundee
Original Assignee
University of Dundee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Dundee filed Critical University of Dundee
Publication of AU2009326261A1 publication Critical patent/AU2009326261A1/en
Application granted granted Critical
Publication of AU2009326261B2 publication Critical patent/AU2009326261B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2009326261A 2008-12-10 2009-12-09 Compounds for use in the treatment of pain Ceased AU2009326261B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0822486.7 2008-12-10
GBGB0822486.7A GB0822486D0 (en) 2008-12-10 2008-12-10 Compounds for use in the treatment of pain
PCT/GB2009/002850 WO2010067069A1 (en) 2008-12-10 2009-12-09 Compounds for use in the treatment of pain

Publications (2)

Publication Number Publication Date
AU2009326261A1 AU2009326261A1 (en) 2011-06-30
AU2009326261B2 true AU2009326261B2 (en) 2016-03-24

Family

ID=40289770

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009326261A Ceased AU2009326261B2 (en) 2008-12-10 2009-12-09 Compounds for use in the treatment of pain

Country Status (8)

Country Link
US (1) US8507724B2 (enExample)
EP (1) EP2373605B1 (enExample)
JP (1) JP5732400B2 (enExample)
CN (1) CN102307836B (enExample)
AU (1) AU2009326261B2 (enExample)
CA (1) CA2747232C (enExample)
GB (1) GB0822486D0 (enExample)
WO (1) WO2010067069A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2522651B1 (en) 2011-05-12 2013-11-20 Siegfried AG Process for the purification of 2,6-diisopropyl phenol
JP6186974B2 (ja) * 2012-07-30 2017-08-30 Jnc株式会社 液晶組成物、酸化防止剤および液晶表示素子
GB201322905D0 (en) 2013-12-23 2014-02-12 Univ Liverpool Pharmacologically active compounds
KR102056649B1 (ko) * 2014-09-04 2019-12-17 스촨 하이스코 파마수티컬 씨오., 엘티디 진정제 및 마취제의 제조에서의 ｇａｂａａ 수용체 강화제의 용도
CA3010506A1 (en) * 2016-01-06 2017-07-13 The Board Of Trustees Of The University Of Illinois Novel compounds which activate estrogen receptors and compositions and methods of using the same
US10449198B2 (en) 2016-07-01 2019-10-22 The University Of Liverpool Method for treating pain
CN116554127B (zh) * 2022-01-28 2025-03-21 成都麻沸散医药科技有限公司 哌嗪取代苯酚类衍生物及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0789898A (ja) * 1993-09-27 1995-04-04 Ono Pharmaceut Co Ltd ビフェニル誘導体
WO2007071967A2 (en) * 2005-12-19 2007-06-28 The University Of Liverpool Substituted phenol derivatives as analgesics

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3979199A (en) * 1998-05-12 1999-11-29 American Home Products Corporation 11-aryl-benzo{b}naphtho{2,3-d}furans and 11-aryl-benzo{b}naphtho{2,3-d}thiophenes useful in the treatment of insulin resistance and hyperglycemia
HRP20000767A2 (en) * 1998-05-12 2001-10-31 American Home Prod Benzothiophenes, benzofurans and indoles useful in the treatment of insulin resistance and hyperglycemia
US6121271A (en) * 1998-05-12 2000-09-19 American Home Products Corporation Naphtho[2,3-B]heteroar-4-yl derivatives
TWI283577B (en) * 1999-10-11 2007-07-11 Sod Conseils Rech Applic Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
JP2002093609A (ja) * 2000-09-14 2002-03-29 Univ Waseda ラジカル高分子化合物からなる磁性素子
CA2556398A1 (en) * 2004-02-16 2005-08-25 Laboratorios Del Dr. Esteve S.A. Substituted azetidine compounds as cyclooxygenase-1-cyclooxygenase-2 inhibitors, and their preparation and use as medicaments
JP2005234086A (ja) * 2004-02-18 2005-09-02 Konica Minolta Medical & Graphic Inc 光熱写真画像形成材料
EP1853240A2 (en) * 2005-02-18 2007-11-14 Abraxis BioScience, Inc. Compositions, methods of use and preparation of 2,6-diisopropyl phenol and analogs for ischemic injury
CN1907954B (zh) * 2006-08-16 2011-11-23 重庆医科大学医药研究所 麻醉药2,6-二异丙基苯酚的水溶性衍生物及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0789898A (ja) * 1993-09-27 1995-04-04 Ono Pharmaceut Co Ltd ビフェニル誘導体
WO2007071967A2 (en) * 2005-12-19 2007-06-28 The University Of Liverpool Substituted phenol derivatives as analgesics

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CAS Registry Number 168196-71-2, STN Entry Date 29 September 1995. *
CAS Registry Number 168196-82-5, STN Entry Date 29 September 1995. *

Also Published As

Publication number Publication date
CA2747232C (en) 2017-01-17
AU2009326261A1 (en) 2011-06-30
CA2747232A1 (en) 2010-06-17
WO2010067069A1 (en) 2010-06-17
CN102307836B (zh) 2014-03-19
JP5732400B2 (ja) 2015-06-10
EP2373605B1 (en) 2014-08-13
US20120029235A1 (en) 2012-02-02
CN102307836A (zh) 2012-01-04
GB0822486D0 (en) 2009-01-14
EP2373605A1 (en) 2011-10-12
US8507724B2 (en) 2013-08-13
JP2012511558A (ja) 2012-05-24

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired