AU2009238701B2 - Multimeric forms of antimicrobial peptides - Google Patents
Multimeric forms of antimicrobial peptides Download PDFInfo
- Publication number
- AU2009238701B2 AU2009238701B2 AU2009238701A AU2009238701A AU2009238701B2 AU 2009238701 B2 AU2009238701 B2 AU 2009238701B2 AU 2009238701 A AU2009238701 A AU 2009238701A AU 2009238701 A AU2009238701 A AU 2009238701A AU 2009238701 B2 AU2009238701 B2 AU 2009238701B2
- Authority
- AU
- Australia
- Prior art keywords
- peptide
- amino acid
- multimer
- isolated
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 102000044503 Antimicrobial Peptides Human genes 0.000 title abstract description 4
- 108700042778 Antimicrobial Peptides Proteins 0.000 title abstract description 4
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- 238000000034 method Methods 0.000 claims abstract description 73
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- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 25
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- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 32
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 32
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 24
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- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims description 14
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims description 14
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- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 11
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- YEDUAINPPJYDJZ-UHFFFAOYSA-N 2-hydroxybenzothiazole Chemical compound C1=CC=C2SC(O)=NC2=C1 YEDUAINPPJYDJZ-UHFFFAOYSA-N 0.000 description 3
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Eyeglasses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4658408P | 2008-04-21 | 2008-04-21 | |
| US61/046,584 | 2008-04-21 | ||
| PCT/SG2009/000144 WO2009131548A1 (en) | 2008-04-21 | 2009-04-21 | Multimeric forms of antimicrobial peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2009238701A1 AU2009238701A1 (en) | 2009-10-29 |
| AU2009238701B2 true AU2009238701B2 (en) | 2013-06-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009238701A Ceased AU2009238701B2 (en) | 2008-04-21 | 2009-04-21 | Multimeric forms of antimicrobial peptides |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8809262B2 (enExample) |
| EP (2) | EP2853539B1 (enExample) |
| JP (2) | JP5753077B2 (enExample) |
| AU (1) | AU2009238701B2 (enExample) |
| BR (1) | BRPI0910473A2 (enExample) |
| SG (1) | SG10201406288SA (enExample) |
| WO (1) | WO2009131548A1 (enExample) |
| ZA (1) | ZA201007509B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8691945B2 (en) * | 2006-04-27 | 2014-04-08 | Singapore Health Services Pte Ltd. | Antimicrobial peptides |
| US20110311601A1 (en) * | 2010-06-22 | 2011-12-22 | Michael Kleine | Antimicrobial medical devices |
| CN107652364A (zh) * | 2011-04-02 | 2018-02-02 | 新加坡保健服务集团 | 抗菌肽的多聚体形式 |
| EP2892913A4 (en) * | 2012-09-07 | 2017-01-18 | Agency For Science, Technology And Research | Peptides and their uses |
| WO2014039013A1 (en) | 2012-09-07 | 2014-03-13 | Agency Of Science, Technology And Research | Tetrabranched peptides and analogues as a new class of antimicrobials and their preparation thereof |
| JP6362878B2 (ja) * | 2013-03-12 | 2018-07-25 | 国立研究開発法人農業・食品産業技術総合研究機構 | 改変ペプチド繰り返しペプチドを含む融合タンパク質および該融合タンパク質を含むシルク繊維 |
| WO2015138494A1 (en) | 2014-03-10 | 2015-09-17 | Georges Belfort | Anti-microbial peptides and method for designing novel anti-microbial peptides |
| US10780294B2 (en) | 2014-11-19 | 2020-09-22 | The General Hospital Corporation | System and method for photo-dynamic procedure |
| WO2016191790A1 (en) * | 2015-05-29 | 2016-12-08 | Hexima Limited | A method of in vivo treatment |
| KR20180086277A (ko) * | 2015-12-14 | 2018-07-30 | 수 한 | 폴리펩티드 화합물, 그리고 이의 제조 방법 및 적용 |
| WO2020168265A1 (en) | 2019-02-14 | 2020-08-20 | Singapore Eye Research Institute | Antibacterial compositions |
| US20230398177A1 (en) * | 2020-10-22 | 2023-12-14 | The University Of Hong Kong | Compositions of anti-viral peptides and/or compounds and methods of use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007007116A1 (en) * | 2005-07-14 | 2007-01-18 | Ares Trading S.A | Defensin proteins |
| WO2007025178A2 (en) * | 2005-08-26 | 2007-03-01 | New York University | Rolyvalent multimeric compositions containing active polypeptides, pharmaceutical compositions and methods of using the same |
| WO2007126392A1 (en) * | 2006-04-27 | 2007-11-08 | Singapore Health Services Pte Ltd | Antimicrobial peptides |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5057520A (en) * | 1989-03-24 | 1991-10-15 | Abbott Laboratories | 7-(peptidylpyrolidinyl)naphthyridine antibacterial compounds |
| US5639594A (en) * | 1990-02-16 | 1997-06-17 | United Biomedical, Inc. | Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis |
| US5919761A (en) * | 1992-08-14 | 1999-07-06 | The Board Of Regents Of The University Of Michigan | Peptides for heparin and low molecular weight heparin anticoagulation reversal |
| US8172395B2 (en) | 2002-12-03 | 2012-05-08 | Novartis Ag | Medical devices having antimicrobial coatings thereon |
| US7531505B2 (en) * | 2006-01-11 | 2009-05-12 | Affinergy, Inc. | Compositions and methods for promoting attachment of cells of endothelial cell lineage to medical devices |
-
2009
- 2009-04-21 EP EP14190318.7A patent/EP2853539B1/en not_active Not-in-force
- 2009-04-21 BR BRPI0910473A patent/BRPI0910473A2/pt not_active IP Right Cessation
- 2009-04-21 WO PCT/SG2009/000144 patent/WO2009131548A1/en not_active Ceased
- 2009-04-21 JP JP2011506235A patent/JP5753077B2/ja not_active Expired - Fee Related
- 2009-04-21 EP EP09734345.3A patent/EP2279202B1/en not_active Not-in-force
- 2009-04-21 SG SG10201406288SA patent/SG10201406288SA/en unknown
- 2009-04-21 US US12/988,994 patent/US8809262B2/en not_active Expired - Fee Related
- 2009-04-21 AU AU2009238701A patent/AU2009238701B2/en not_active Ceased
-
2010
- 2010-10-21 ZA ZA2010/07509A patent/ZA201007509B/en unknown
-
2015
- 2015-02-20 JP JP2015031712A patent/JP2015145373A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007007116A1 (en) * | 2005-07-14 | 2007-01-18 | Ares Trading S.A | Defensin proteins |
| WO2007025178A2 (en) * | 2005-08-26 | 2007-03-01 | New York University | Rolyvalent multimeric compositions containing active polypeptides, pharmaceutical compositions and methods of using the same |
| WO2007126392A1 (en) * | 2006-04-27 | 2007-11-08 | Singapore Health Services Pte Ltd | Antimicrobial peptides |
Non-Patent Citations (4)
| Title |
|---|
| ARNUSCH C J ET AL: "Enhanced membrane pore formation by multimeric/oligomeric antimicrobial peptides", BIOCHEMISTRY 20071120 AMERICAN CHEMICAL SOCIETY US, vol. 46, no. 46, 20 November 2007, pages 13437-13442 * |
| CAMPOPIANO, D. J. et al "Structure-Activity Relationships in Defensin Dimers" The Journal of Biological Chemistry , Vol. 279, No. 47, Issue of November 19, pp. 48671- 48679, 2004 * |
| HOOVER, D. M. ET AL "The Structure of Human B -Defensin-2 Shows Evidence of Higher Order Oligomerization" The Journal of Biological Chemistry, Vol. 275, No. 42, Issue of October 20, pp. 32911-32918, 2000 * |
| SCHIBLI David J et al. The Journal of Biological Chemistry, Vol. 277, No. 10, Issue of March 8, pp. 8279- 8289, 2002 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2279202A4 (en) | 2011-08-31 |
| WO2009131548A8 (en) | 2010-11-25 |
| EP2853539A1 (en) | 2015-04-01 |
| JP2011521902A (ja) | 2011-07-28 |
| EP2853539B1 (en) | 2018-10-10 |
| BRPI0910473A2 (pt) | 2019-09-24 |
| JP5753077B2 (ja) | 2015-07-22 |
| AU2009238701A1 (en) | 2009-10-29 |
| SG10201406288SA (en) | 2014-12-30 |
| WO2009131548A1 (en) | 2009-10-29 |
| EP2279202A1 (en) | 2011-02-02 |
| US20110039760A1 (en) | 2011-02-17 |
| US8809262B2 (en) | 2014-08-19 |
| EP2279202B1 (en) | 2015-08-12 |
| JP2015145373A (ja) | 2015-08-13 |
| ZA201007509B (en) | 2013-06-26 |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |