AU2009238701B2 - Multimeric forms of antimicrobial peptides - Google Patents

Multimeric forms of antimicrobial peptides Download PDF

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Publication number
AU2009238701B2
AU2009238701B2 AU2009238701A AU2009238701A AU2009238701B2 AU 2009238701 B2 AU2009238701 B2 AU 2009238701B2 AU 2009238701 A AU2009238701 A AU 2009238701A AU 2009238701 A AU2009238701 A AU 2009238701A AU 2009238701 B2 AU2009238701 B2 AU 2009238701B2
Authority
AU
Australia
Prior art keywords
peptide
amino acid
multimer
isolated
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009238701A
Other languages
English (en)
Other versions
AU2009238701A1 (en
Inventor
Roger W. Beuerman
Jing Li
Shouping Liu
Donald Tan
Chandra Shekhar Verma
Lei Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agency for Science, Technology and Research
Singapore Health Services Pte Ltd
Original Assignee
Agency for Science, Technology and Research
Singapore Health Services Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency for Science, Technology and Research, Singapore Health Services Pte Ltd filed Critical Agency for Science, Technology and Research
Publication of AU2009238701A1 publication Critical patent/AU2009238701A1/en
Application granted granted Critical
Publication of AU2009238701B2 publication Critical patent/AU2009238701B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Eyeglasses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
AU2009238701A 2008-04-21 2009-04-21 Multimeric forms of antimicrobial peptides Ceased AU2009238701B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4658408P 2008-04-21 2008-04-21
US61/046,584 2008-04-21
PCT/SG2009/000144 WO2009131548A1 (en) 2008-04-21 2009-04-21 Multimeric forms of antimicrobial peptides

Publications (2)

Publication Number Publication Date
AU2009238701A1 AU2009238701A1 (en) 2009-10-29
AU2009238701B2 true AU2009238701B2 (en) 2013-06-20

Family

ID=41217076

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009238701A Ceased AU2009238701B2 (en) 2008-04-21 2009-04-21 Multimeric forms of antimicrobial peptides

Country Status (8)

Country Link
US (1) US8809262B2 (enExample)
EP (2) EP2853539B1 (enExample)
JP (2) JP5753077B2 (enExample)
AU (1) AU2009238701B2 (enExample)
BR (1) BRPI0910473A2 (enExample)
SG (1) SG10201406288SA (enExample)
WO (1) WO2009131548A1 (enExample)
ZA (1) ZA201007509B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009535027A (ja) * 2006-04-27 2009-10-01 シンガポール ヘルス サービシーズ ピーティーイー リミテッド 抗菌ペプチド
US20110311601A1 (en) * 2010-06-22 2011-12-22 Michael Kleine Antimicrobial medical devices
CN102260321A (zh) * 2011-04-02 2011-11-30 新加坡保健服务集团 抗菌肽的多聚体形式
EP2892913A4 (en) * 2012-09-07 2017-01-18 Agency For Science, Technology And Research Peptides and their uses
EP2892914B1 (en) * 2012-09-07 2018-05-23 Agency For Science, Technology And Research Tetrabranched peptides and analogues as a new class of antimicrobials and their preparation thereof
JP6362878B2 (ja) * 2013-03-12 2018-07-25 国立研究開発法人農業・食品産業技術総合研究機構 改変ペプチド繰り返しペプチドを含む融合タンパク質および該融合タンパク質を含むシルク繊維
WO2015138494A1 (en) 2014-03-10 2015-09-17 Georges Belfort Anti-microbial peptides and method for designing novel anti-microbial peptides
WO2016081594A1 (en) * 2014-11-19 2016-05-26 The General Hospital Corporation System and method for photo-dynamic procedure
EP3303376A4 (en) * 2015-05-29 2019-01-23 Hexima Limited IN VIVO METHOD
EP3392263A4 (en) * 2015-12-14 2020-03-04 Su Han POLYPEPTIDE COMPOUND, METHOD FOR PREPARING THE SAME, AND USE THEREOF
US20220133699A1 (en) 2019-02-14 2022-05-05 Singapore Eye Research Institute Antibacterial Compositions
EP4232460A4 (en) * 2020-10-22 2024-10-09 The University of Hong Kong COMPOSITIONS OF ANTIVIRAL PEPTIDES AND/OR COMPOUNDS AND METHODS OF USE THEREOF
US20240197823A1 (en) * 2021-02-12 2024-06-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Cationic antimicrobial peptides and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007007116A1 (en) * 2005-07-14 2007-01-18 Ares Trading S.A Defensin proteins
WO2007025178A2 (en) * 2005-08-26 2007-03-01 New York University Rolyvalent multimeric compositions containing active polypeptides, pharmaceutical compositions and methods of using the same
WO2007126392A1 (en) * 2006-04-27 2007-11-08 Singapore Health Services Pte Ltd Antimicrobial peptides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057520A (en) * 1989-03-24 1991-10-15 Abbott Laboratories 7-(peptidylpyrolidinyl)naphthyridine antibacterial compounds
US5639594A (en) * 1990-02-16 1997-06-17 United Biomedical, Inc. Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis
US5919761A (en) * 1992-08-14 1999-07-06 The Board Of Regents Of The University Of Michigan Peptides for heparin and low molecular weight heparin anticoagulation reversal
US8172395B2 (en) * 2002-12-03 2012-05-08 Novartis Ag Medical devices having antimicrobial coatings thereon
US7531505B2 (en) * 2006-01-11 2009-05-12 Affinergy, Inc. Compositions and methods for promoting attachment of cells of endothelial cell lineage to medical devices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007007116A1 (en) * 2005-07-14 2007-01-18 Ares Trading S.A Defensin proteins
WO2007025178A2 (en) * 2005-08-26 2007-03-01 New York University Rolyvalent multimeric compositions containing active polypeptides, pharmaceutical compositions and methods of using the same
WO2007126392A1 (en) * 2006-04-27 2007-11-08 Singapore Health Services Pte Ltd Antimicrobial peptides

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARNUSCH C J ET AL: "Enhanced membrane pore formation by multimeric/oligomeric antimicrobial peptides", BIOCHEMISTRY 20071120 AMERICAN CHEMICAL SOCIETY US, vol. 46, no. 46, 20 November 2007, pages 13437-13442 *
CAMPOPIANO, D. J. et al "Structure-Activity Relationships in Defensin Dimers" The Journal of Biological Chemistry , Vol. 279, No. 47, Issue of November 19, pp. 48671- 48679, 2004 *
HOOVER, D. M. ET AL "The Structure of Human B -Defensin-2 Shows Evidence of Higher Order Oligomerization" The Journal of Biological Chemistry, Vol. 275, No. 42, Issue of October 20, pp. 32911-32918, 2000 *
SCHIBLI David J et al. The Journal of Biological Chemistry, Vol. 277, No. 10, Issue of March 8, pp. 8279- 8289, 2002 *

Also Published As

Publication number Publication date
ZA201007509B (en) 2013-06-26
JP5753077B2 (ja) 2015-07-22
AU2009238701A1 (en) 2009-10-29
JP2015145373A (ja) 2015-08-13
WO2009131548A1 (en) 2009-10-29
US8809262B2 (en) 2014-08-19
SG10201406288SA (en) 2014-12-30
EP2279202B1 (en) 2015-08-12
EP2853539B1 (en) 2018-10-10
EP2853539A1 (en) 2015-04-01
BRPI0910473A2 (pt) 2019-09-24
EP2279202A1 (en) 2011-02-02
US20110039760A1 (en) 2011-02-17
WO2009131548A8 (en) 2010-11-25
EP2279202A4 (en) 2011-08-31
JP2011521902A (ja) 2011-07-28

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired