AU2009235931B2 - Treatment of tumors - Google Patents

Treatment of tumors Download PDF

Info

Publication number
AU2009235931B2
AU2009235931B2 AU2009235931A AU2009235931A AU2009235931B2 AU 2009235931 B2 AU2009235931 B2 AU 2009235931B2 AU 2009235931 A AU2009235931 A AU 2009235931A AU 2009235931 A AU2009235931 A AU 2009235931A AU 2009235931 B2 AU2009235931 B2 AU 2009235931B2
Authority
AU
Australia
Prior art keywords
ace2
polypeptide
tumour
cancer
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2009235931A
Other languages
English (en)
Other versions
AU2009235931A1 (en
Inventor
Evelyne Janzek-Hawlat
Hans Loibner
Bernhard Peball
Manfred Schuster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apeiron Biologics GmbH
Original Assignee
Apeiron Biologics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apeiron Biologics GmbH filed Critical Apeiron Biologics GmbH
Publication of AU2009235931A1 publication Critical patent/AU2009235931A1/en
Application granted granted Critical
Publication of AU2009235931B2 publication Critical patent/AU2009235931B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/17—Metallocarboxypeptidases (3.4.17)
    • C12Y304/17023—Angiotensin-converting enzyme 2 (3.4.17.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2009235931A 2008-04-09 2009-04-07 Treatment of tumors Active AU2009235931B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT0056608A AT506632A1 (de) 2008-04-09 2008-04-09 Behandlung von tumorerkrankungen
ATA566/2008 2008-04-09
PCT/AT2009/000136 WO2009124330A2 (de) 2008-04-09 2009-04-07 Behandlung von tumorerkrankungen

Publications (2)

Publication Number Publication Date
AU2009235931A1 AU2009235931A1 (en) 2009-10-15
AU2009235931B2 true AU2009235931B2 (en) 2015-07-23

Family

ID=41130316

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009235931A Active AU2009235931B2 (en) 2008-04-09 2009-04-07 Treatment of tumors

Country Status (12)

Country Link
US (1) US8946162B2 (https=)
EP (2) EP2644203A1 (https=)
JP (1) JP5650639B2 (https=)
AT (1) AT506632A1 (https=)
AU (1) AU2009235931B2 (https=)
CA (1) CA2720616C (https=)
DK (1) DK2274005T3 (https=)
ES (1) ES2425308T3 (https=)
NZ (1) NZ588435A (https=)
PL (1) PL2274005T3 (https=)
PT (1) PT2274005E (https=)
WO (1) WO2009124330A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT505262A1 (de) * 2007-06-12 2008-12-15 Apeiron Biolog Forschungs Und Rekombinantes ace2 polypeptid
DK2859343T3 (da) * 2012-06-06 2019-12-09 Attoquant Diagnostics Gmbh Fremgangsmåde til måling af peptidiske nedbrydningsprodukter af en proteolytisk kaskade i blodprøver
US8557958B1 (en) 2012-06-18 2013-10-15 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of diabetes
US8633158B1 (en) 2012-10-02 2014-01-21 Tarix Pharmaceuticals Ltd. Angiotensin in treating brain conditions
AU2014204769B2 (en) * 2013-01-14 2016-08-11 Apeiron Biologics Ag Modified ACE2 polypeptides
ES2761562T3 (es) * 2013-12-11 2020-05-20 Alterras Therapeutics Gmbh Composiciones y procedimientos para el tratamiento de enfermedades relacionadas con el sistema renina-angiotensina
US9333233B2 (en) 2014-02-25 2016-05-10 Tarix Pharmaceuticals Ltd. Methods and compositions for the delayed treatment of stroke
US20200188473A1 (en) * 2017-05-02 2020-06-18 Beth Israel Deaconess Medical Center, Inc. Combination therapy for cancer
EP3717077A1 (en) 2017-11-29 2020-10-07 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Methods for modulating pigmentation by angiotensin-converting enzyme 2 modulation
WO2021190980A1 (en) 2020-03-22 2021-09-30 Quadrucept Bio Limited Multimers for viral strain evolution
WO2021202912A1 (en) * 2020-04-01 2021-10-07 Washington University Compositions for treatment of viral respiratory infections and methods of use thereof
CN112626099A (zh) * 2020-09-29 2021-04-09 清华大学 使用原核细胞发酵表达血管紧张素转化酶2的方法
WO2022184659A1 (en) 2021-03-01 2022-09-09 Quadrucept Bio Limited Antibody domains & multimers
WO2023102156A1 (en) 2021-12-03 2023-06-08 Wisconsin Alumni Research Foundation Mutant ace2 proteins and methods of using same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004000367A1 (en) * 2002-06-19 2003-12-31 University Health Network Ace2 activation for treatment of heart, lung and kidney disease and hypertension
US20050147600A1 (en) * 1997-12-11 2005-07-07 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and uses therefor
US20080159962A1 (en) * 2005-05-19 2008-07-03 Imba-Institute Fur Molekulare Biotechnologie Gmbh Use of Inhibitors of the Renin-Angiotensin System for the Treatment of Lung Injuries
WO2008151347A1 (de) * 2007-06-12 2008-12-18 Apeiron Biologics Forschungs- Und Entwicklungsgesellschaft M.B.H. Ace2 polypeptid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194556B1 (en) 1997-12-11 2001-02-27 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therfor
US6989363B1 (en) 1997-12-11 2006-01-24 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
WO2003072059A2 (en) * 2002-02-27 2003-09-04 Wake Forest University Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth
EP1374907A3 (en) 2002-06-24 2004-01-07 Ghanem Elias c/o Institut Jules Bordet Ghanem Drug transport and delivery system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050147600A1 (en) * 1997-12-11 2005-07-07 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and uses therefor
WO2004000367A1 (en) * 2002-06-19 2003-12-31 University Health Network Ace2 activation for treatment of heart, lung and kidney disease and hypertension
US20080159962A1 (en) * 2005-05-19 2008-07-03 Imba-Institute Fur Molekulare Biotechnologie Gmbh Use of Inhibitors of the Renin-Angiotensin System for the Treatment of Lung Injuries
WO2008151347A1 (de) * 2007-06-12 2008-12-18 Apeiron Biologics Forschungs- Und Entwicklungsgesellschaft M.B.H. Ace2 polypeptid

Also Published As

Publication number Publication date
WO2009124330A3 (de) 2009-12-10
JP5650639B2 (ja) 2015-01-07
ES2425308T3 (es) 2013-10-14
EP2644203A1 (de) 2013-10-02
NZ588435A (en) 2012-10-26
EP2274005A2 (de) 2011-01-19
AU2009235931A1 (en) 2009-10-15
EP2274005B1 (de) 2013-05-29
PL2274005T3 (pl) 2013-12-31
AT506632A1 (de) 2009-10-15
PT2274005E (pt) 2013-08-27
CA2720616A1 (en) 2009-10-15
US20110033524A1 (en) 2011-02-10
WO2009124330A2 (de) 2009-10-15
US8946162B2 (en) 2015-02-03
JP2011516501A (ja) 2011-05-26
CA2720616C (en) 2016-08-09
DK2274005T3 (da) 2013-08-19

Similar Documents

Publication Publication Date Title
AU2009235931B2 (en) Treatment of tumors
Dai et al. Modular peptide probe for pre/intra/postoperative therapeutic to reduce recurrence in ovarian cancer
TWI584815B (zh) 活化素-ＡｃｔＲＩＩａ拮抗劑及其治療或預防乳癌之用途
CN112402622B (zh) 靶向pd-l1的抗肿瘤多肽纳米药物载体及其应用
AU2016363683B2 (en) Monocarboxylate transporter 4 (MCT4) antisense oligonucleotide (ASO) inhibitors for use as therapeutics in the treatment of cancer
EA028590B1 (ru) Ингибиторы мет для повышения эффективности лучевой терапии
Xu et al. Interleukin-12 in multimodal tumor therapies for induction of anti-tumor immunity
US20220267770A1 (en) Compositions and methods of using c/ebp alpha sarna
Xia et al. Transferrin-guided intelligent nanovesicles augment the targetability and potency of clinical PLK1 inhibitor to acute myeloid leukemia
JP2021527651A (ja) Ｃ／ＥＢＰアルファｓａＲＮＡを含む併用療法
Darban et al. Targeting the leptin receptor: To evaluate therapeutic efficacy and anti-tumor effects of Doxil, in vitro and in vivo in mice bearing C26 colon carcinoma tumor
AU2016366566B2 (en) Improved angiogenesis-inhibiting peptide and composition for preventing and treating angiogenesis-related disease comprising same as active ingredient
Wang et al. Methionine enkephalin inhibits colorectal cancer by remodeling the immune status of the tumor microenvironment
Du et al. Chemotherapy based on “Domino-effect” combined with immunotherapy amplifying the efficacy of an anti-metastatic treatment
Li et al. An albumin-prodrug injectable formulation for synergistic cancer immunotherapy
CN110215511B (zh) 微肽asrps在治疗癌症中的应用
CN110551197B (zh) 一种微肽及癌症治疗的药物
WO2022229644A1 (en) Combination therapies comprising c/ebp alpha sarna
US20240247031A1 (en) Composition for treating cancer containing telomerase-targeting gnrh antagonist-derived peptide hs1002
US20080096793A1 (en) Class III Slrp for the Treatment of Cancer
Nikolaienko et al. Effective model for antitumor drugs screening based on 3D growth system of MCF-7
JP2021031389A (ja) 放射線治療効果増強剤

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)