AU2009220931B2 - N-substitutedbenzenepropanamide or benzenepropenamide derivatives for use in the treatment of pain and inflammation - Google Patents

N-substitutedbenzenepropanamide or benzenepropenamide derivatives for use in the treatment of pain and inflammation Download PDF

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Publication number
AU2009220931B2
AU2009220931B2 AU2009220931A AU2009220931A AU2009220931B2 AU 2009220931 B2 AU2009220931 B2 AU 2009220931B2 AU 2009220931 A AU2009220931 A AU 2009220931A AU 2009220931 A AU2009220931 A AU 2009220931A AU 2009220931 B2 AU2009220931 B2 AU 2009220931B2
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AU
Australia
Prior art keywords
compound
compounds
pain
pharmaceutical composition
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2009220931A
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English (en)
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AU2009220931A1 (en
Inventor
Eliahu Kaplan
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Novaremed Ltd
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Novaremed Ltd
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Publication of AU2009220931A1 publication Critical patent/AU2009220931A1/en
Application granted granted Critical
Publication of AU2009220931B2 publication Critical patent/AU2009220931B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/90—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated
    • C07C233/91—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated with carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyethers (AREA)
AU2009220931A 2008-03-06 2009-03-06 N-substitutedbenzenepropanamide or benzenepropenamide derivatives for use in the treatment of pain and inflammation Ceased AU2009220931B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0804213.7A GB0804213D0 (en) 2008-03-06 2008-03-06 A method of printing or preventing pain
GB0804213.7 2008-03-06
PCT/IB2009/000448 WO2009109850A2 (en) 2008-03-06 2009-03-06 A method of treating or preventing pain

Publications (2)

Publication Number Publication Date
AU2009220931A1 AU2009220931A1 (en) 2009-09-11
AU2009220931B2 true AU2009220931B2 (en) 2014-11-13

Family

ID=39327664

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009220931A Ceased AU2009220931B2 (en) 2008-03-06 2009-03-06 N-substitutedbenzenepropanamide or benzenepropenamide derivatives for use in the treatment of pain and inflammation

Country Status (12)

Country Link
US (2) US8883853B2 (https=)
EP (1) EP2323644B1 (https=)
JP (1) JP5657394B2 (https=)
AU (1) AU2009220931B2 (https=)
CA (1) CA2717692C (https=)
DK (1) DK2323644T3 (https=)
ES (1) ES2505325T3 (https=)
GB (1) GB0804213D0 (https=)
IL (1) IL207965A (https=)
PL (1) PL2323644T3 (https=)
PT (1) PT2323644E (https=)
WO (1) WO2009109850A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4939396B2 (ja) 2004-03-26 2012-05-23 ノヴァレメッド リミテッド Ａｉｄｓ及び他のウイルス性疾患及びｈｉｖ関連感染症の改善又はその治療用化合物及びそのような化合物を含む組成物、そのような疾患及び感染症の治療方法及びそのような化合物及び組成物の製造方法
GB0804213D0 (en) 2008-03-06 2008-04-16 New Era Biotech Ltd A method of printing or preventing pain
US8802734B2 (en) * 2009-09-09 2014-08-12 Novaremed Limited Method of treating or preventing pain
EP2475361B1 (en) * 2009-09-09 2019-11-06 Novaremed Ltd. N-substituted benzenepropanamides for use in the treatment of pain and inflammation
GB201116335D0 (en) * 2011-09-21 2011-11-02 Novaremed Ltd A method of treating or preventing affective disorders
DK2788317T3 (da) * 2011-12-08 2020-01-20 Novaremed Ltd Isolerede stereoisomere former af (S)2-N(3-O-((S)propan-2-ol)-1-propyl-4-hydroxybenzen)-3-phenylpropylamid
CN113329746B (zh) 2019-01-23 2025-05-02 诺瓦麦有限公司 用于治疗或预防疼痛、炎症和/或自身免疫的化合物
EP3939578A1 (en) 2020-07-13 2022-01-19 Novaremed Ltd. Compounds for treatment or prevention of an infection resulting from a coronavirus and/or a coronavirus-induced disease
WO2026037478A1 (en) 2023-08-11 2026-02-19 Novaremed AG (s,s)-(3-o-(propan-2-ol)-2-amino-prop-1-yl-4-hydroxybenzene and its analogues for the treatment of chronic pain

Citations (4)

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WO1997023202A1 (en) * 1995-12-22 1997-07-03 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON Subtype-selective nmda receptor ligands and the use thereof
EP0877340A1 (en) * 1997-05-06 1998-11-11 Konami Co., Ltd. Apparatus and method for processing an image display and a readable storage medium storing a computer program
WO2004031129A2 (en) * 2002-10-03 2004-04-15 New Era Biotech, Ltd. Compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection
EP1876169A1 (en) * 2005-03-25 2008-01-09 Obschestvo S Ogranichennoi Otvetstennostiyu "Pharmenterprises" Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof

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US2908691A (en) 1958-07-14 1959-10-13 Searle & Co Hydroxyphenalkylaminoalkylindoles and ethers corresponding thereto
GB1037655A (en) * 1964-05-20 1966-08-03 Koninklijke Pharma Fab Nv Di(aralkyl)amines
ZA732136B (en) 1972-04-12 1974-03-27 Lilly Co Eli Dopamine derivatives
JPS5236606A (en) 1975-09-12 1977-03-22 Tanabe Seiyaku Co Ltd Process for preparation of amino compounds
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4908322A (en) 1985-09-06 1990-03-13 The United States Of America As Represented By The Department Of Health And Human Services Derivatization of amines for electrochemical detection
US5552558A (en) 1989-05-23 1996-09-03 Abbott Laboratories Retroviral protease inhibiting compounds
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
JP2848232B2 (ja) 1993-02-19 1999-01-20 武田薬品工業株式会社 アルデヒド誘導体
EP0887340A4 (en) * 1996-02-06 2000-03-29 Japan Tobacco Inc CHEMICAL COMPOUNDS AND THEIR PHARMACEUTICAL USE
WO2002046176A1 (en) 2000-12-05 2002-06-13 Nippon Chemiphar Co., Ltd. Ppar (peroxisome proliferator activated receptor) activators
EP1581510A4 (en) * 2002-11-22 2006-08-30 Bristol Myers Squibb Co 1-ARYL-2-HYDROXYETHYLAMIDEALS CALIUM CHANNEL OPENER
JP4939396B2 (ja) * 2004-03-26 2012-05-23 ノヴァレメッド リミテッド Ａｉｄｓ及び他のウイルス性疾患及びｈｉｖ関連感染症の改善又はその治療用化合物及びそのような化合物を含む組成物、そのような疾患及び感染症の治療方法及びそのような化合物及び組成物の製造方法
DE102004039373A1 (de) * 2004-08-12 2006-02-23 Grünenthal GmbH Para-Alkyl-substituierte N-(4-Hydroxy-3-methoxy-benzyl)-zimtsäureamide und deren Verwendung zur Herstellung von Arzneimitteln
EP2026775B1 (en) * 2006-05-09 2015-04-29 Novaremed Ltd. Use of syk tyrosine kinase inhibitors for the treatment of cell proliferative disorders
AU2008302356A1 (en) * 2007-09-17 2009-03-26 Academia Sinica Compositions and methods for treating inflammation and inflammation-related disorders by Plectranthus Amboinicus extracts
GB0804213D0 (en) 2008-03-06 2008-04-16 New Era Biotech Ltd A method of printing or preventing pain
CN101503370B (zh) 2009-03-02 2012-08-22 上海应用技术学院 一种n-环丙基-反-2-顺-6-壬二烯酸酰胺的合成方法
CN101503373B (zh) * 2009-03-13 2013-07-24 山东大学 2-氨基-1-(4-硝基苯基)-1-乙醇类金属蛋白酶抑制剂及其制备方法和用途
US8802734B2 (en) 2009-09-09 2014-08-12 Novaremed Limited Method of treating or preventing pain

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023202A1 (en) * 1995-12-22 1997-07-03 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON Subtype-selective nmda receptor ligands and the use thereof
EP0877340A1 (en) * 1997-05-06 1998-11-11 Konami Co., Ltd. Apparatus and method for processing an image display and a readable storage medium storing a computer program
WO2004031129A2 (en) * 2002-10-03 2004-04-15 New Era Biotech, Ltd. Compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection
EP1876169A1 (en) * 2005-03-25 2008-01-09 Obschestvo S Ogranichennoi Otvetstennostiyu "Pharmenterprises" Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Lee, Y-T. et al, Clinica Chimica Acta, 2005, v. 352, pp. 135-141 *
Marquez, L. et al, Acta Farm. Bonaerense, 2005, vol. 24, pp. 325-330 *
Park, J.B., J. Agric. Food Chem., 2007, vol. 55, pp. 2171-2175 *

Also Published As

Publication number Publication date
CA2717692A1 (en) 2009-09-11
US20150080473A1 (en) 2015-03-19
JP2011513377A (ja) 2011-04-28
ES2505325T3 (es) 2014-10-09
US8883853B2 (en) 2014-11-11
CA2717692C (en) 2016-06-07
US9199917B2 (en) 2015-12-01
WO2009109850A2 (en) 2009-09-11
PT2323644E (pt) 2014-07-25
US20110039936A1 (en) 2011-02-17
IL207965A (en) 2015-10-29
WO2009109850A3 (en) 2009-12-10
PL2323644T3 (pl) 2014-10-31
JP5657394B2 (ja) 2015-01-21
GB0804213D0 (en) 2008-04-16
EP2323644A2 (en) 2011-05-25
AU2009220931A1 (en) 2009-09-11
EP2323644B1 (en) 2014-04-23
DK2323644T3 (da) 2014-07-21
IL207965A0 (en) 2010-12-30

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired