AU2009207478B2 - Indolyl- pyridone derivatives having checkpoint kinase 1 inhibitory activity - Google Patents

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Publication number

AU2009207478B2

AU2009207478B2 AU2009207478A AU2009207478A AU2009207478B2 AU 2009207478 B2 AU2009207478 B2 AU 2009207478B2 AU 2009207478 A AU2009207478 A AU 2009207478A AU 2009207478 A AU2009207478 A AU 2009207478A AU 2009207478 B2 AU2009207478 B2 AU 2009207478B2

Authority

AU

Australia

Prior art keywords

title compound

oxo

carboxylic acid

dihydro

pyridin

Prior art date

2008-01-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
• Discuss

• 108010019244 Checkpoint Kinase 1 Proteins 0.000 title abstract description 28
• 230000002401 inhibitory effect Effects 0.000 title abstract description 4
• 102000006459 Checkpoint Kinase 1 Human genes 0.000 title description 27
• NRGVEGWSRITVOR-UHFFFAOYSA-N 3-(1h-indol-2-yl)-1h-pyridin-2-one Chemical class OC1=NC=CC=C1C1=CC2=CC=CC=C2N1 NRGVEGWSRITVOR-UHFFFAOYSA-N 0.000 title description 6
• 150000001875 compounds Chemical class 0.000 claims abstract description 525
• 102100031081 Serine/threonine-protein kinase Chk1 Human genes 0.000 claims abstract 4
• 101000777293 Homo sapiens Serine/threonine-protein kinase Chk1 Proteins 0.000 claims abstract 3
• -1 hydroxy, methyl Chemical group 0.000 claims description 63
• 229910052739 hydrogen Inorganic materials 0.000 claims description 49
• 238000000034 method Methods 0.000 claims description 49
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 47
• 239000001257 hydrogen Substances 0.000 claims description 47
• 229910052757 nitrogen Inorganic materials 0.000 claims description 42
• 239000000203 mixture Substances 0.000 claims description 36
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 29
• 150000002431 hydrogen Chemical group 0.000 claims description 27
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 26
• 206010028980 Neoplasm Diseases 0.000 claims description 19
• 230000000694 effects Effects 0.000 claims description 19
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 17
• 238000011282 treatment Methods 0.000 claims description 17
• 125000001424 substituent group Chemical group 0.000 claims description 16
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 15
• 150000003839 salts Chemical class 0.000 claims description 15
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 14
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 14
• CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 13
• 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims description 12
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 12
• 125000001153 fluoro group Chemical group F* 0.000 claims description 12
• 125000005842 heteroatom Chemical group 0.000 claims description 12
• 125000000217 alkyl group Chemical group 0.000 claims description 11
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 11
• 201000011510 cancer Diseases 0.000 claims description 11
• 125000000623 heterocyclic group Chemical group 0.000 claims description 11
• 229910052760 oxygen Inorganic materials 0.000 claims description 11
• 239000001301 oxygen Substances 0.000 claims description 11
• 125000002950 monocyclic group Chemical group 0.000 claims description 9
• YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 8
• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 8
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 8
• 239000005864 Sulphur Chemical group 0.000 claims description 8
• 125000005843 halogen group Chemical group 0.000 claims description 8
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
• 230000005764 inhibitory process Effects 0.000 claims description 7
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 6
• 125000004193 piperazinyl group Chemical group 0.000 claims description 6
• 125000003226 pyrazolyl group Chemical group 0.000 claims description 6
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 5
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 5
• 238000001959 radiotherapy Methods 0.000 claims description 5
• 241000124008 Mammalia Species 0.000 claims description 4
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
• 231100000433 cytotoxic Toxicity 0.000 claims description 4
• 230000001472 cytotoxic effect Effects 0.000 claims description 4
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 4
• 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims description 4
• 239000008194 pharmaceutical composition Substances 0.000 claims description 4
• 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims description 3
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 3
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 3
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 3
• 208000023275 Autoimmune disease Diseases 0.000 claims description 3
• 238000002512 chemotherapy Methods 0.000 claims description 3
• 125000001309 chloro group Chemical group Cl* 0.000 claims description 3
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 3
• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 3
• 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims description 3
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 2
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 2
• YRNZHBVRTDDGNB-UHFFFAOYSA-N 1-benzyl-n-[5-(1h-indol-2-yl)-6-oxo-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C=1NC(=O)C(C=2NC3=CC=CC=C3C=2)=CC=1NC(=O)C(=C1)C=NN1CC1=CC=CC=C1 YRNZHBVRTDDGNB-UHFFFAOYSA-N 0.000 claims description 2
• 125000004484 1-methylpiperidin-4-yl group Chemical group CN1CCC(CC1)* 0.000 claims description 2
• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims description 2
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 2
• 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims description 2
• 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 2
• 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims description 2
• 206010052779 Transplant rejections Diseases 0.000 claims description 2
• 239000000824 cytostatic agent Substances 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 206010025135 lupus erythematosus Diseases 0.000 claims description 2
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 2
• 201000006417 multiple sclerosis Diseases 0.000 claims description 2
• 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims description 2
• 210000000056 organ Anatomy 0.000 claims description 2
• 201000008482 osteoarthritis Diseases 0.000 claims description 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
• 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 2
• 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
• 102000001253 Protein Kinase Human genes 0.000 claims 5
• 108060006633 protein kinase Proteins 0.000 claims 5
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
• GEBXRQMORXJPGN-UHFFFAOYSA-N 1-[(4-methylphenyl)methyl]-n-[6-oxo-5-[5-(piperidin-1-ylmethyl)-1h-indol-2-yl]-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C1=CC(C)=CC=C1CN1N=CC(C(=O)NC=2C=C(C(=O)NC=2)C=2NC3=CC=C(CN4CCCCC4)C=C3C=2)=C1 GEBXRQMORXJPGN-UHFFFAOYSA-N 0.000 claims 1
• DISCGKGWZKLOSH-UHFFFAOYSA-N 1-benzyl-n-[5-[5-(2,2-dimethyl-3-piperidin-1-ylpropoxy)-1h-indol-2-yl]-6-oxo-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C1CCCCN1CC(C)(C)COC(C=C1C=2)=CC=C1NC=2C(C(NC=1)=O)=CC=1NC(=O)C(=C1)C=NN1CC1=CC=CC=C1 DISCGKGWZKLOSH-UHFFFAOYSA-N 0.000 claims 1
• ZSYVTFSMHIZBJT-UHFFFAOYSA-N 1-benzyl-n-[5-[5-(2,2-dimethyl-3-pyrrolidin-1-ylpropoxy)-1h-indol-2-yl]-6-oxo-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C1CCCN1CC(C)(C)COC(C=C1C=2)=CC=C1NC=2C(C(NC=1)=O)=CC=1NC(=O)C(=C1)C=NN1CC1=CC=CC=C1 ZSYVTFSMHIZBJT-UHFFFAOYSA-N 0.000 claims 1
• DKDWHPAIWPQMDV-UHFFFAOYSA-N 1-benzyl-n-[5-[5-[(4-fluoropiperidin-1-yl)methyl]-1h-indol-2-yl]-6-oxo-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C1CC(F)CCN1CC1=CC=C(NC(=C2)C=3C(NC=C(NC(=O)C4=CN(CC=5C=CC=CC=5)N=C4)C=3)=O)C2=C1 DKDWHPAIWPQMDV-UHFFFAOYSA-N 0.000 claims 1
• QENZBLJVRSQXHR-UHFFFAOYSA-N 1-benzyl-n-[5-[5-[(4-methylpiperidin-1-yl)methyl]-1h-indol-2-yl]-6-oxo-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C1CC(C)CCN1CC1=CC=C(NC(=C2)C=3C(NC=C(NC(=O)C4=CN(CC=5C=CC=CC=5)N=C4)C=3)=O)C2=C1 QENZBLJVRSQXHR-UHFFFAOYSA-N 0.000 claims 1
• OUZSVHBSAIWGAB-UHFFFAOYSA-N 1-benzyl-n-[5-[5-[1-(dimethylamino)-2-methylpropan-2-yl]oxy-1h-indol-2-yl]-6-oxo-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C=1C2=CC(OC(C)(C)CN(C)C)=CC=C2NC=1C(C(NC=1)=O)=CC=1NC(=O)C(=C1)C=NN1CC1=CC=CC=C1 OUZSVHBSAIWGAB-UHFFFAOYSA-N 0.000 claims 1
• WMBKHLMCZPQUSY-UHFFFAOYSA-N 1-benzyl-n-[5-[5-[3-(diethylamino)-2,2-dimethylpropoxy]-1h-indol-2-yl]-6-oxo-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C=1C2=CC(OCC(C)(C)CN(CC)CC)=CC=C2NC=1C(C(NC=1)=O)=CC=1NC(=O)C(=C1)C=NN1CC1=CC=CC=C1 WMBKHLMCZPQUSY-UHFFFAOYSA-N 0.000 claims 1
• REQMZUHAMVOEON-UHFFFAOYSA-N 1-benzyl-n-[5-[5-[3-(dimethylamino)-2,2-dimethylpropoxy]-1h-indol-2-yl]-6-oxo-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C=1C2=CC(OCC(C)(C)CN(C)C)=CC=C2NC=1C(C(NC=1)=O)=CC=1NC(=O)C(=C1)C=NN1CC1=CC=CC=C1 REQMZUHAMVOEON-UHFFFAOYSA-N 0.000 claims 1
• PZNCUDMYMQBNPI-OAQYLSRUSA-N 1-benzyl-n-[5-[5-[[(2r)-2-methylpiperidin-1-yl]methyl]-1h-indol-2-yl]-6-oxo-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C[C@@H]1CCCCN1CC1=CC=C(NC(=C2)C=3C(NC=C(NC(=O)C4=CN(CC=5C=CC=CC=5)N=C4)C=3)=O)C2=C1 PZNCUDMYMQBNPI-OAQYLSRUSA-N 0.000 claims 1
• ITWISLBDFHAZFK-OYRHEFFESA-N 1-benzyl-n-[5-[5-[[(2r,6s)-2,6-dimethylmorpholin-4-yl]methyl]-1h-indol-2-yl]-6-oxo-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C1[C@@H](C)O[C@@H](C)CN1CC1=CC=C(NC(=C2)C=3C(NC=C(NC(=O)C4=CN(CC=5C=CC=CC=5)N=C4)C=3)=O)C2=C1 ITWISLBDFHAZFK-OYRHEFFESA-N 0.000 claims 1
• KIBWTTYZBWVWLR-SZPZYZBQSA-N 1-benzyl-n-[5-[5-[[(2r,6s)-2,6-dimethylpiperidin-1-yl]methyl]-1h-indol-2-yl]-6-oxo-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C[C@H]1CCC[C@@H](C)N1CC1=CC=C(NC(=C2)C=3C(NC=C(NC(=O)C4=CN(CC=5C=CC=CC=5)N=C4)C=3)=O)C2=C1 KIBWTTYZBWVWLR-SZPZYZBQSA-N 0.000 claims 1
• PZNCUDMYMQBNPI-NRFANRHFSA-N 1-benzyl-n-[5-[5-[[(2s)-2-methylpiperidin-1-yl]methyl]-1h-indol-2-yl]-6-oxo-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C[C@H]1CCCCN1CC1=CC=C(NC(=C2)C=3C(NC=C(NC(=O)C4=CN(CC=5C=CC=CC=5)N=C4)C=3)=O)C2=C1 PZNCUDMYMQBNPI-NRFANRHFSA-N 0.000 claims 1
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• NOMVGDXJBPVSOA-UHFFFAOYSA-N 1-benzyl-n-[5-[5-[[[3-(dimethylamino)-2,2-dimethylpropyl]-ethylamino]methyl]-1h-indol-2-yl]-6-oxo-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C=1C2=CC(CN(CC)CC(C)(C)CN(C)C)=CC=C2NC=1C(C(NC=1)=O)=CC=1NC(=O)C(=C1)C=NN1CC1=CC=CC=C1 NOMVGDXJBPVSOA-UHFFFAOYSA-N 0.000 claims 1
• OEKPFDMUKNSTBS-UHFFFAOYSA-N 1-benzyl-n-[6-oxo-5-[5-(piperidin-1-ylmethyl)-1h-indol-2-yl]-1h-pyridin-3-yl]pyrazole-4-carboxamide Chemical compound C1=NN(CC=2C=CC=CC=2)C=C1C(=O)NC(C=1)=CNC(=O)C=1C(NC1=CC=2)=CC1=CC=2CN1CCCCC1 OEKPFDMUKNSTBS-UHFFFAOYSA-N 0.000 claims 1
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