AU2009204849B2 - Vaccine comprising a ribosomal protein extract (RPE) and optionally a Th1-promoting adjuvant - Google Patents

Vaccine comprising a ribosomal protein extract (RPE) and optionally a Th1-promoting adjuvant Download PDF

Info

Publication number
AU2009204849B2
AU2009204849B2 AU2009204849A AU2009204849A AU2009204849B2 AU 2009204849 B2 AU2009204849 B2 AU 2009204849B2 AU 2009204849 A AU2009204849 A AU 2009204849A AU 2009204849 A AU2009204849 A AU 2009204849A AU 2009204849 B2 AU2009204849 B2 AU 2009204849B2
Authority
AU
Australia
Prior art keywords
mice
ribosomal
ribosomal protein
lrpe
leishmania
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009204849A
Other languages
English (en)
Other versions
AU2009204849A1 (en
Inventor
Daniel Ruiz Abanades
Manuel Soto Alvarez
Carlos Alonso Bedate
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Leti SA
Original Assignee
Laboratorios Leti SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Leti SA filed Critical Laboratorios Leti SA
Publication of AU2009204849A1 publication Critical patent/AU2009204849A1/en
Application granted granted Critical
Publication of AU2009204849B2 publication Critical patent/AU2009204849B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/002Protozoa antigens
    • A61K39/008Leishmania antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2009204849A 2008-01-18 2009-01-14 Vaccine comprising a ribosomal protein extract (RPE) and optionally a Th1-promoting adjuvant Ceased AU2009204849B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2192808P 2008-01-18 2008-01-18
EP08100634.8 2008-01-18
US61/021,928 2008-01-18
EP08100634 2008-01-18
PCT/EP2009/050334 WO2009090175A1 (en) 2008-01-18 2009-01-14 Vaccine comprising a ribosomal protein extract (rpe) and optionally a th1-promoting adjuvant

Publications (2)

Publication Number Publication Date
AU2009204849A1 AU2009204849A1 (en) 2009-07-23
AU2009204849B2 true AU2009204849B2 (en) 2013-10-03

Family

ID=39471089

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009204849A Ceased AU2009204849B2 (en) 2008-01-18 2009-01-14 Vaccine comprising a ribosomal protein extract (RPE) and optionally a Th1-promoting adjuvant

Country Status (19)

Country Link
US (1) US20110020405A1 (enExample)
EP (2) EP2231700B1 (enExample)
JP (2) JP2011509968A (enExample)
CN (1) CN101977930B (enExample)
AP (1) AP3007A (enExample)
AU (1) AU2009204849B2 (enExample)
BR (1) BRPI0906787A2 (enExample)
CA (1) CA2712475A1 (enExample)
CO (1) CO6280495A2 (enExample)
DK (1) DK2231700T3 (enExample)
ES (1) ES2486365T3 (enExample)
HR (1) HRP20140447T1 (enExample)
MA (1) MA32080B1 (enExample)
MX (1) MX2010007831A (enExample)
PL (1) PL2231700T3 (enExample)
PT (1) PT2231700E (enExample)
RU (1) RU2521499C2 (enExample)
WO (1) WO2009090175A1 (enExample)
ZA (1) ZA201005143B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SA110310855B1 (ar) 2009-11-13 2014-09-16 Laboratories Leti S L Unipersonal استخدام مصدر l3 و/ أو l5 كلقاح أو كوسيلة تشخيصية لمرض طفيلي
SG190222A1 (en) 2010-11-10 2013-06-28 Leti Sl Lab New adjuvant

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1279679A1 (en) * 2000-04-17 2003-01-29 C.B.F. Leti, S.A. Composition containing leishmania lip2a

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500437B1 (en) * 1995-09-22 2002-12-31 Corixa Corporation Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
PT1141305E (pt) * 1998-12-23 2006-10-31 Leti Lab Gene quimerico formado pelas sequencias de adn que codifica os determinantes antigenicos de quatro proteinas de l. infantum
US20030072714A1 (en) * 2001-10-12 2003-04-17 Magill Alan J. Microfluidized leishmania lysate and methods of making and using thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1279679A1 (en) * 2000-04-17 2003-01-29 C.B.F. Leti, S.A. Composition containing leishmania lip2a

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Immunogenicity of a ribosomal antigen of Leishmania enriettii", Transactions of the Royal Spciety of Tropical Medicine and Hygiene, 1971, 65(1):18-19 *
Iborra S et al, "The immunodominant T helper 2 (Th2) response elicited in BALB/c mice by the Leishmania LiP2a and LiP2b acidic ribosomal proteins cannot be reverted by strong Th1 inducers", 2007, 150(2):375-385 *

Also Published As

Publication number Publication date
RU2010134427A (ru) 2012-02-27
JP2015180638A (ja) 2015-10-15
EP2231700B1 (en) 2014-05-07
PL2231700T3 (pl) 2014-09-30
JP2011509968A (ja) 2011-03-31
HRP20140447T1 (hr) 2014-07-04
MA32080B1 (fr) 2011-02-01
AP3007A (en) 2014-10-31
CN101977930A (zh) 2011-02-16
WO2009090175A1 (en) 2009-07-23
CA2712475A1 (en) 2009-07-23
EP2570427A1 (en) 2013-03-20
AP2010005333A0 (en) 2010-08-31
DK2231700T3 (da) 2014-07-14
AU2009204849A1 (en) 2009-07-23
PT2231700E (pt) 2014-07-31
CO6280495A2 (es) 2011-05-20
MX2010007831A (es) 2011-06-20
US20110020405A1 (en) 2011-01-27
HK1150291A1 (en) 2011-11-18
RU2521499C2 (ru) 2014-06-27
ES2486365T3 (es) 2014-08-18
ZA201005143B (en) 2011-12-28
BRPI0906787A2 (pt) 2015-08-18
EP2231700A1 (en) 2010-09-29
CN101977930B (zh) 2014-12-17

Similar Documents

Publication Publication Date Title
Klinman CpG DNA as a vaccine adjuvant
Iborra et al. Vaccination with the Leishmania major ribosomal proteins plus CpG oligodeoxynucleotides induces protection against experimental cutaneous leishmaniasis in mice
Rhee et al. Vaccination with heat-killed Leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+ and CD8+ T cell responses and protection against Leishmania major infection
Ivory et al. DNA vaccines: designing strategies against parasitic infections
Katebi et al. Leishmania tarentolae secreting the sand fly salivary antigen PpSP15 confers protection against Leishmania major infection in a susceptible BALB/c mice model
JP5623995B2 (ja) 寄生虫疾患の処置のための特異的ヒストンの使用
Sánchez et al. Homologous prime-boost strategy with TgPI-1 improves the immune response and protects highly susceptible mice against chronic Toxoplasma gondii infection
Jin et al. Induction of active immune suppression by co-immunization with DNA-and protein-based vaccines
AU2009204849B2 (en) Vaccine comprising a ribosomal protein extract (RPE) and optionally a Th1-promoting adjuvant
CA2780740C (en) The use of an l3 and/or l5 source as a vaccine or as a diagnostic for a parasitic disease
Mazumder et al. Non-coding pDNA bearing immunostimulatory sequences co-entrapped with leishmanial antigens in cationic liposomes elicits almost complete protection against experimental visceral leishmaniasis in BALB/c mice
US8206725B2 (en) Immunogenic agent and pharmaceutical composition for use against homologous and heterologous pathogens including plasmodium SPP
HK1150291B (en) Vaccine comprising a ribosomal protein extract (rpe) and optionally a th1-promoting adjuvant
Oligodeoxynucleotides Coinjection with CpG-Containing
Verthelyi Prevention and Treatment of Cutaneous Leishmaniasis in Primates by Using Synthetic Type D/A Oligodeoxynucleotides Expressing CpG Motifs
AU2004266028A1 (en) Immunogenic agent and pharmaceutical composition for use against homologous and heterologous pathogens including Plasmodium spp
AU2012201243A1 (en) Immunogenic agent and pharmaceutical composition for use against homologous and heterologous pathogens including plasmodium spp

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired