AU2009201609A1 - Microtube reader device for the analysis of blood samples - Google Patents
Microtube reader device for the analysis of blood samples Download PDFInfo
- Publication number
- AU2009201609A1 AU2009201609A1 AU2009201609A AU2009201609A AU2009201609A1 AU 2009201609 A1 AU2009201609 A1 AU 2009201609A1 AU 2009201609 A AU2009201609 A AU 2009201609A AU 2009201609 A AU2009201609 A AU 2009201609A AU 2009201609 A1 AU2009201609 A1 AU 2009201609A1
- Authority
- AU
- Australia
- Prior art keywords
- microtubes
- analysis
- blood samples
- microtube
- grid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004458 analytical method Methods 0.000 title claims description 30
- 239000008280 blood Substances 0.000 title claims description 18
- 210000004369 blood Anatomy 0.000 title claims description 18
- 238000000034 method Methods 0.000 claims description 14
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 230000031700 light absorption Effects 0.000 claims description 2
- 239000012535 impurity Substances 0.000 claims 1
- 230000000877 morphologic effect Effects 0.000 claims 1
- 238000011156 evaluation Methods 0.000 description 9
- 208000031226 Hyperlipidaemia Diseases 0.000 description 5
- 206010018910 Haemolysis Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000008588 hemolysis Effects 0.000 description 3
- 206010053567 Coagulopathies Diseases 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000002547 anomalous effect Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000035602 clotting Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 241000282412 Homo Species 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
- G01N21/278—Constitution of standards
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
- G01N21/5907—Densitometers
- G01N2021/5969—Scanning of a tube, a cuvette, a volume of sample
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/8806—Specially adapted optical and illumination features
- G01N2021/8829—Shadow projection or structured background, e.g. for deflectometry
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Hydrology & Water Resources (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Description
S&F Ref: 897990 AUSTRALIA PATENTS ACT 1990 COMPLETE SPECIFICATION FOR A STANDARD PATENT Name and Address Grifols, S.A., of Marina,16-18, Torre Mapfre, Planta 26, of Applicant: 08005, Barcelona, Spain Actual Inventor(s): Benigno Gonzalez Corbella Address for Service: Spruson & Ferguson St Martins Tower Level 35 31 Market Street Sydney NSW 2000 (CCN 3710000177) Invention Title: Microtube reader device for the analysis of blood samples The following statement is a full description of this invention, including the best method of performing it known to me/us: 5845c(2071611_1) I MICROTUBE READER DEVICE FOR THE ANALYSIS OF BLOOD SAMPLES DESCRIPTION 5 This invention discloses a device for reading microtubes of the type incorporated into the so-called cards for the analysis of blood samples. The use of microtubes for the analysis of samples, especially blood samples, is widespread in the clinical sector, and can be used to evaluate the results of the reaction of a sample in each individual microtube holding an appropriate gel, with the provision of 10 appropriate reagents. After the sample for analysis has been poured into the gel-containing microtube and the necessary reagents for the analysis required have been added, after a specified period of time and after the necessary processes have been carried out an expert clinician can evaluate the result of the test by visual inspection of the tube contents, observing is whether any areas of different colour have formed in the mass of the gel, the distribution of colour masses, deposits at the bottom of the microtube, supernatant, etc. However, the use of microtubes for the analysis of samples currently suffers from the need of an excessive intervention of expert personnel for the observation of the microtubes, above all when making the necessary evaluations of the results of the test. 20 Likewise there is little systematic evaluation of the results obtained in the tests. This invention is intended to overcome the disadvantages mentioned above by providing means to allow much better use of the possibility of reading microtube test results and thus making possible a higher level of automation in the process of reading and interpreting test results. The invention also makes microtube evaluation in advance 25 easier. In order to accomplish its objectives this invention is essentially based on a device essentially comprising the combination of a camera obtaining colour images designed to capture the image of the microtubes in a card located on a back lighted support provided with a pattern of marks specially intended to facilitate interpretation of 30 the initial state of the microtube and interpretation of the results obtained. In this way the device according to the invention makes it possible, also in an automated way, to: i) check and evaluate microtubes before use, for example for gel content or other characteristics. ii) interpret results, in particular in the analysis of blood samples, by 35 determining: 2 - the results of haemolysis - evaluating lipaemia - the results of clotting - gel/supematant transition 5 - others. iii) detect anomalous samples, especially as regards colour intensity and the dispersion of light in the supernatant. To sum up, this invention is based on the combination of a camera capturing colour images of microtubes for analysis, both before and after tests have been carried out io on a sample, with the combination of a background grid or grids which can be superimposed on the microtube image by back lighting, thus providing a system for the analysis of blood samples in microtubes that is completely automated and is also capable of distinguishing false clotting not brought about by red cells. According to a first aspect there is provided a method for reading microtubes for is the analysis of blood samples, wherein colour pictures of back-lighted analysis microtubes are taken and that the colour information in the images is used to distinguish relevant areas of the image to interpret the result of other possible artefacts as well as to detect anomalous samples and/or reactions characterised by changes in the colour properties of the reaction. 20 According to a second aspect there is provided a microtube reader device for the analysis of blood samples, wherein said device has a camera to capture colour images of the analysis microtubes in a card fitted in support and has back-lighting means and intermediate grids between the illuminating source and the microtubes. A number of explanatory drawings of embodiments of this invention and results 25 in actual microtubes are provided by way of example, to provide a better understanding. Figure 1 illustrates diagrammatically the arrangement of the essential means forming the device to which the invention relates. Figure 2 shows diagrammatically a microtube indicating the areas inspected when determining the initial state of the microtube. 30 Figure 3 is a figure similar to Figure 2 showing the areas in which colour is detected and levels for final inspection of the microtube. Figure 4 shows an illumination contrast pattern intended to be superimposed on the microtube at the time when images are obtained. Figure 5 shows a series of photographs of haemolysed samples taken by the 35 device so that the effect of haemolysis can be better understood.
3 Figure 6 shows a series of photographs of lipaemic samples to improve understanding of the effect of lipaemia. Figure 7 shows an actual photograph of two microtubes in which it will be seen how the gel level can be assessed using the dark line located behind the microtube. 5 Figure 8 shows an actual photograph of two microtubes as an example of a negative reaction and a partly positive reaction. The drawings illustrate diagrammatically a microtube reader device for the analysis of blood samples according to this invention, in which the camera for obtaining colour images -2- is located above a supporting plate -1- with a back-lighting device, not 10 shown in the figure, and a transparent or translucent frame -4- for positioning the patterns with specific grids for the purpose of automatic evaluation of the microtubes before the test and the results of the test performed. A small plate -3- reduces the effects of reflection on the images acquired produced in the areas which do not correspond to the microtubes. Figure 4 shows a pattern plate -5- which can be attached to frame -4- and is bears a transparent or translucent zone -6- with the grid which is to be superimposed on the microtubes located in front of frame -4- by back-lighting so that the marks in the pattern can provide guidelines for human or automatic interpretation of the test results. Merely by way of example marks are shown for two microtubes, each of which comprises a vertical mark, such as -7- and -8-, and pairs of horizontal marks -9- and -10- so that the 20 microtubes can be observed systematically both before and after the tests are carried out with the corresponding samples, thus together assisting the means for either manual, that is human, evaluation, or automatic evaluation, that is by the device itself, which can be incorporated into an automatic apparatus for the analysis of samples or to a reading apparatus. 25 Through use of the device and method according to this invention it is possible to carry out an initial inspection of a microtube, as illustrated in Figure 2, in which is shown a microtube -11- in which the initial gel level -12-, which might have been adversely affected by incorrect pipetting or for other reasons, can be detected, and through which the uniformity of gel -13- can be detected, detecting for example the presence of bubbles. 30 After the corresponding analyses have been performed, Figure 3 illustrates another microtube -14- which when the latter is finally inspected permits to reveal the total dose level in upper area -15- which might have been adversely affected by incorrect pipetting, as well as the detection of the colour intensity in areas -16-, -17- and -18-, and the turbidity in area -19-, including marks -20- and -21-.
4 Figure 5 shows various photographs of haemolysed samples indicated by the numbers -22-, -23-, -24-, -25-, -26- and -27- respectively. Each of these show two microtubes with different evaluations of the haemolysed samples, showing the percentage of haemolysed cells, with a total volume of 10 pl. Variations from 100% in photograph 5 -22- to 0% in photograph -27- respectively will be seen, as a result of which this invention can be used to evaluate the percentages of haemolysed cells both manually, that is to say by humans, and in an automated way. Figure 6 shows photographs of lipaemic samples -28-, -29-, -30-, -31- and -32 which provide an easy evaluation of lipaemia through the turbidity in the microtube 10 contrasting against a background grid based on horizontal lines -33- or another similar grid. It will be seen from photograph -28- to photograph -32- that there is a clear gradation in turbidity with respect to the background lines, as a result of which the level of lipaemia in the blood sample analysed can be evaluated. Figure 7 shows two microtubes -34- and -35- which can be used to check the is level of gel using the dark line which appears in the pattern behind the microtube. Figure 8 shows an actual photograph of two microtubes similar to those in Figure 7 in which microtubes -36- and -37- respectively show a zone -38- indicative of a negative reaction, and a partly positive reaction in microtube -37-. It will therefore be seen that the invention also discloses the device intended for 20 reading microtubes and analysing blood samples, as well as the method which more generally makes it possible to use the invention for automating the process, which essentially comprises reading the microtubes for the analysis of samples both before and after the tests are carried out by obtaining a colour image with simultaneous back-lighting of the microtube card having a pattern with a specific grid or grids which can be adjusted 25 to the type of test carried out being placed in between, making it possible to automatically read the microtubes in the cards before use for analysis, above all in order to check that the parameters which establish that the microtube is initially in a proper condition lie within the envisaged range of values. The method likewise comprises evaluation of the colour of various areas of the microtube once a test has been performed on a sample, and 30 other specific parameters to evaluate the results of specific types such as: haemolysis, turbidity (lipaemia) and others. The images obtained can be processed on the basis of the colour and light absorption (turbidity) information to transform the colour images captured by the device into data to evaluate the analysis in an automated way.
5 The invention is defined by the following claims, and it must be understood that many variants may be included within the scope of the invention by those skilled in the art on the basis of the information provided by this description, claims and drawings.
Claims (8)
- 2. The method for reading microtubes for the analysis of blood samples to according to claim 1, wherein the image obtained is evaluated visually or automatically in the presence of background grids for evaluating levels, light absorption, colour in reactions and the morphological distribution of the image of the reactions in the analysis microtubes. 15 3. The method for reading microtubes for the analysis of blood samples according to claim 2, wherein the initial characteristics of the microtube are evaluated to ensure that impurities, bubbles and other artefacts are absent and that levels are correct before the sample is received, by evaluating the degree to which a background grid appears/disappears. 20
- 4. The method according to claim 3, wherein said background grid is vertical.
- 5. The method for reading microtubes for the analysis of blood samples 25 according to claim 2, wherein the turbidity of the reaction is evaluated using the degree to which a grid appears/disappears.
- 6. The method according to claim 5, wherein said grid is horizontal. 30 7. A method according to claim 1, substantially as hereinbefore described with reference to any one of the examples and/or the figures.
- 8. A microtube reader device for the analysis of blood samples, wherein said device has a camera to capture colour images of the analysis microtubes in a card 35 fitted in support and has back-lighting means and intermediate grids between the 7 illuminating source and the microtubes.
- 9. The microtube reader device for the analysis of blood samples according to claim 8, wherein the intermediate patterns between the lighting source and the 5 microtubes may or may not be present in the area of interest of the image, by moving either the patterns, the microtubes or the camera or by any other equivalent means.
- 10. The microtube reader device for the analysis of blood samples according to claim 8, wherein the assembly supporting the camera and the support for the grid and 10 the microtubes forms an assembly which can be fitted as a unit into apparatus for the automatic analysis of samples or in a separate reading equipment.
- 11. A device according to claim 8, substantially as hereinbefore described with reference to any one of the examples and/or figures. 15 Dated 21 April 2009 Grifols, S.A. Patent Attorneys for the Applicant/Nominated Person 20 SPRUSON & FERGUSON
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200801398 | 2008-05-14 | ||
ES200801398A ES2312290B1 (en) | 2008-05-14 | 2008-05-14 | MICROTUBE READING DEVICE FOR BLOOD SAMPLE ANALYSIS. |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2009201609A1 true AU2009201609A1 (en) | 2009-12-03 |
AU2009201609B2 AU2009201609B2 (en) | 2011-06-02 |
Family
ID=40339492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2009201609A Active AU2009201609B2 (en) | 2008-05-14 | 2009-04-22 | Microtube reader device for the analysis of blood samples |
Country Status (12)
Country | Link |
---|---|
US (1) | US20100221765A1 (en) |
EP (1) | EP2120038A3 (en) |
JP (1) | JP4881973B2 (en) |
CN (1) | CN101581676B (en) |
AR (1) | AR071498A1 (en) |
AU (1) | AU2009201609B2 (en) |
BR (1) | BRPI0901542A2 (en) |
CA (1) | CA2661677A1 (en) |
CL (1) | CL2009001163A1 (en) |
ES (1) | ES2312290B1 (en) |
HK (1) | HK1133923A1 (en) |
MX (1) | MX2009003625A (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5645547B2 (en) * | 2010-08-26 | 2014-12-24 | あおい精機株式会社 | Sample testing apparatus and method |
DE102011003140A1 (en) * | 2011-01-25 | 2012-07-26 | Hamilton Bonaduz Ag | Optical analysis method for liquid in a sample container and analysis device for carrying out the method |
WO2018081617A2 (en) | 2016-10-28 | 2018-05-03 | Beckman Coulter, Inc. | Substance preparation evaluation system |
CN106770282B (en) * | 2016-11-25 | 2020-06-26 | 中国人民解放军第三军医大学第二附属医院 | Hemodialysis extracorporeal circulation blood coagulation classifier and blood coagulation classification method using same |
CN109632653B (en) * | 2019-01-23 | 2022-01-04 | 南方医科大学南方医院 | Plasma chyle and hemolysis detection device and method based on camera |
CN110530867A (en) * | 2019-10-11 | 2019-12-03 | 江苏贝索生物工程有限公司 | The micro- test tube reaction cup of cassette and the full-automatic test tube detection method for utilizing the reaction cup |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4609991A (en) * | 1983-07-19 | 1986-09-02 | The United States Of America As Represented By The Department Of Health And Human Services | Automated system for determining the molecular weight and/or concentration of macromolecules via sedimentation equilibrium |
JPS62226057A (en) * | 1986-03-28 | 1987-10-05 | Minoru Tomita | Method and apparatus for measuring agglutination of red blood cell for whole blood |
US5003488A (en) * | 1989-03-10 | 1991-03-26 | Gespac, Inc. | Automatic fluid sedimentation rate measurement apparatus and method |
US5528036A (en) * | 1994-02-17 | 1996-06-18 | Thermedics Detection, Inc. | Spectral detection of contaminants in containers |
CN1181720A (en) * | 1995-04-25 | 1998-05-13 | 伊萝莉公司 | Remotely programmable matrices with memories and uses thereof |
JPH09133687A (en) * | 1995-11-13 | 1997-05-20 | Meiji Denki Kogyo Kk | Instrument for measuring quantity of serum in blood-collecting test tube |
US5872860A (en) * | 1997-03-13 | 1999-02-16 | Ortho Diagnostic Systems, Inc. | Calibration cassette for use in calibrating an automated agglutination reaction analyzing system |
ES2150339B1 (en) * | 1997-07-30 | 2001-06-01 | Grifols Grupo Sa | "UNIVERSAL MACHINE FOR CLINICAL ANALYSIS". |
JP2000227399A (en) * | 1999-02-05 | 2000-08-15 | Pkd:Kk | Preliminary screening device of blood test body |
JP4152650B2 (en) * | 2002-03-18 | 2008-09-17 | セファテクノロジー株式会社 | Apparatus and method for measuring sedimentation rate of liquid sample |
EP2207024B1 (en) * | 2003-07-02 | 2016-05-11 | Terumo BCT, Inc. | Monitoring and control system for blood processing |
JP4177204B2 (en) * | 2003-08-28 | 2008-11-05 | 株式会社日立情報制御ソリューションズ | Container foreign matter inspection system |
CN2733344Y (en) * | 2005-01-26 | 2005-10-12 | 青海省血液中心 | Dedicated photoelectric nephelometer for trace quantity blood sampling fast fat-blood quantitative determination |
JP5198820B2 (en) * | 2006-09-26 | 2013-05-15 | 三菱レイヨン株式会社 | Capillary array sheet inspection apparatus and inspection method |
-
2008
- 2008-05-14 ES ES200801398A patent/ES2312290B1/en active Active
-
2009
- 2009-04-02 EP EP09380071A patent/EP2120038A3/en not_active Ceased
- 2009-04-03 MX MX2009003625A patent/MX2009003625A/en active IP Right Grant
- 2009-04-08 CA CA002661677A patent/CA2661677A1/en not_active Abandoned
- 2009-04-22 AU AU2009201609A patent/AU2009201609B2/en active Active
- 2009-04-23 AR ARP090101435A patent/AR071498A1/en active IP Right Grant
- 2009-05-04 US US12/434,813 patent/US20100221765A1/en not_active Abandoned
- 2009-05-07 CN CN2009101376891A patent/CN101581676B/en active Active
- 2009-05-12 BR BRPI0901542-6A patent/BRPI0901542A2/en not_active Application Discontinuation
- 2009-05-13 JP JP2009116919A patent/JP4881973B2/en active Active
- 2009-05-13 CL CL2009001163A patent/CL2009001163A1/en unknown
-
2010
- 2010-02-17 HK HK10101721.2A patent/HK1133923A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
ES2312290A1 (en) | 2009-02-16 |
CA2661677A1 (en) | 2009-11-14 |
EP2120038A2 (en) | 2009-11-18 |
BRPI0901542A2 (en) | 2010-01-26 |
ES2312290B1 (en) | 2009-09-22 |
AU2009201609B2 (en) | 2011-06-02 |
US20100221765A1 (en) | 2010-09-02 |
JP4881973B2 (en) | 2012-02-22 |
MX2009003625A (en) | 2009-11-26 |
JP2009276349A (en) | 2009-11-26 |
AR071498A1 (en) | 2010-06-23 |
EP2120038A3 (en) | 2012-08-08 |
CL2009001163A1 (en) | 2009-10-02 |
CN101581676A (en) | 2009-11-18 |
HK1133923A1 (en) | 2010-04-09 |
CN101581676B (en) | 2012-06-27 |
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FGA | Letters patent sealed or granted (standard patent) | ||
DA2 | Applications for amendment section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ GONZALEZ CORBELLA, BENIGNO. |