AU2008244074B2 - Antibodies against RAMP3 - Google Patents
Antibodies against RAMP3 Download PDFInfo
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- AU2008244074B2 AU2008244074B2 AU2008244074A AU2008244074A AU2008244074B2 AU 2008244074 B2 AU2008244074 B2 AU 2008244074B2 AU 2008244074 A AU2008244074 A AU 2008244074A AU 2008244074 A AU2008244074 A AU 2008244074A AU 2008244074 B2 AU2008244074 B2 AU 2008244074B2
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- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Landscapes
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Applications Claiming Priority (3)
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| GBGB0708002.1A GB0708002D0 (en) | 2007-04-25 | 2007-04-25 | Antibodies |
| GB0708002.1 | 2007-04-25 | ||
| PCT/GB2008/001454 WO2008132453A1 (en) | 2007-04-25 | 2008-04-23 | Antibodies against ramp3 |
Publications (2)
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| AU2008244074A1 AU2008244074A1 (en) | 2008-11-06 |
| AU2008244074B2 true AU2008244074B2 (en) | 2014-06-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| AU2008244074A Ceased AU2008244074B2 (en) | 2007-04-25 | 2008-04-23 | Antibodies against RAMP3 |
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| US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| GB0521139D0 (en) * | 2005-10-18 | 2005-11-23 | Univ Sheffield | Therapeutic agent |
| CA2647846C (en) | 2006-03-31 | 2016-06-21 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| CA2654623C (en) | 2006-06-08 | 2016-07-26 | Chugai Seiyaku Kabushiki Kaisha | An anti-nr10/il-31ra antibody for use in preventing or treating an inflammatory disease |
| SI2185198T1 (sl) | 2007-08-02 | 2015-04-30 | Gilead Biologics, Inc. | Inhibitorji LOX in LOXL2 ter njihova uporaba |
| PL2202245T3 (pl) | 2007-09-26 | 2017-02-28 | Chugai Seiyaku Kabushiki Kaisha | Sposób modyfikowania punktu izoelektrycznego przeciwciała poprzez podstawienie aminokwasu w cdr |
| WO2009041613A1 (ja) | 2007-09-26 | 2009-04-02 | Chugai Seiyaku Kabushiki Kaisha | 抗体定常領域改変体 |
| MY185647A (en) | 2007-12-05 | 2021-05-27 | Chugai Pharmaceutical Co Ltd | Therapeutic agent for pruritus |
| KR20160074019A (ko) | 2007-12-05 | 2016-06-27 | 추가이 세이야쿠 가부시키가이샤 | 항ｎｒ１０ 항체 및 그의 이용 |
| KR102269708B1 (ko) | 2008-04-11 | 2021-06-25 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| SG190572A1 (en) * | 2008-04-29 | 2013-06-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| PE20100054A1 (es) * | 2008-06-03 | 2010-03-03 | Abbott Lab | Inmunoglobulina con dominio variable dual |
| MX2010014574A (es) * | 2008-07-08 | 2011-04-27 | Abbott Lab | Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas. |
| KR20160062207A (ko) * | 2008-12-05 | 2016-06-01 | 추가이 세이야쿠 가부시키가이샤 | 항ｎｒ１０ 항체 및 그의 이용 |
| JO3382B1 (ar) | 2008-12-23 | 2019-03-13 | Amgen Inc | أجسام مضادة ترتبط مع مستقبل cgrp بشري |
| US9107935B2 (en) | 2009-01-06 | 2015-08-18 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
| US20120071634A1 (en) | 2009-03-19 | 2012-03-22 | Chugai Seiyaku Kabushiki Kaisha | Antibody Constant Region Variant |
| US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| BRPI1012195A2 (pt) * | 2009-05-01 | 2018-04-24 | Abbott Lab | imunoglobulinas de domínio variável duplo e usos das mesmas |
| TW201109438A (en) * | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| CA2771702A1 (en) | 2009-08-21 | 2011-02-24 | Gilead Biologics, Inc. | Catalytic domains from lysyl oxidase and loxl2 |
| AR078651A1 (es) * | 2009-10-15 | 2011-11-23 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| UY32979A (es) * | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| CA2807014A1 (en) | 2010-08-03 | 2012-02-09 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| CA2809433A1 (en) | 2010-08-26 | 2012-03-01 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| EP4231014A3 (en) | 2010-11-30 | 2024-08-14 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| BR112014010008A2 (en) * | 2011-10-26 | 2018-09-04 | Novartis Ag | monoclonal antibodies, their uses and nucleic acids |
| BR112014015851A2 (pt) | 2011-12-30 | 2019-09-24 | Abbvie Inc | proteínas de ligação específicas duplas direcionadas contra il-13 e/ou il-17 |
| BR112015009961B1 (pt) | 2012-11-01 | 2020-10-20 | Abbvie Inc. | proteína de ligação capaz de se ligar a dll4 e vegf, bem como composição que a compreende como composição que a compreende |
| MX2015013166A (es) | 2013-03-15 | 2015-12-11 | Abbvie Inc | Proteinas de union especificas duales dirigidas contra il-1 beta y/o il-17. |
| US10379127B2 (en) | 2013-11-27 | 2019-08-13 | Welcome Receptor Antibodies Pty Ltd | Marker of cell death |
| AU2015318008B2 (en) | 2014-09-15 | 2021-05-20 | Amgen Inc. | Bi-specific anti-CGRP receptor/PAC1 receptor antigen binding proteins and uses thereof |
| WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| MA43918A (fr) | 2015-04-14 | 2018-12-05 | Chugai Pharmaceutical Co Ltd | Composition pharmaceutique pour la prã‰vention et/ou le traitement de la dermatite atopique contenant comme principe actif un antagoniste de l'il-31 |
| HRP20250972T1 (hr) | 2015-04-14 | 2025-10-10 | Chugai Seiyaku Kabushiki Kaisha | Farmaceutski pripravak za prevenciju i/ili liječenje atopijskog dermatitisa koji sadrži il-31 antagonist kao djelatni sastojak |
| JOP20200116A1 (ar) | 2015-04-24 | 2017-06-16 | Amgen Inc | طرق لعلاج أو الوقاية من الصداع النصفي |
| GB201509907D0 (en) * | 2015-06-08 | 2015-07-22 | Urosens Ltd | Antibodies |
| EP3304084B1 (en) | 2015-06-08 | 2022-03-23 | Arquer Diagnostics Limited | Methods and kits |
| CN107771285A (zh) | 2015-06-08 | 2018-03-06 | 阿奎尔诊断有限公司 | 方法 |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| TW201805309A (zh) | 2016-04-21 | 2018-02-16 | 艾伯維史坦森特瑞斯有限責任公司 | 新穎抗－bmpr1b抗體及使用方法 |
| GB201707938D0 (en) | 2017-05-17 | 2017-06-28 | Univ Sheffield | Compounds |
| EP3774881A1 (en) | 2018-04-02 | 2021-02-17 | Amgen Inc. | Erenumab compositions and uses thereof |
| EP3864039B1 (en) * | 2018-10-08 | 2023-12-06 | The UAB Research Foundation | Neuroendocrine cancer targeted therapy |
| GB201818649D0 (en) | 2018-11-15 | 2019-01-02 | Univ Sheffield | Compounds |
| GB201818651D0 (en) | 2018-11-15 | 2019-01-02 | Univ Sheffield | Compounds |
| EP4062933A4 (en) | 2019-11-20 | 2023-12-13 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing preparation |
| CN112920267B (zh) * | 2021-03-09 | 2021-08-13 | 北京康乐卫士生物技术股份有限公司 | 一种抗人乳头瘤病毒31型的单克隆中和抗体及其应用 |
| WO2024102912A1 (en) * | 2022-11-10 | 2024-05-16 | The Children's Medical Center Corporation | Cgrp/ramp1 blockade to treat endometriosis-associated pain and reduce endometriosis lesions |
| GB202303531D0 (en) * | 2023-03-10 | 2023-04-26 | Fusion Antibodies Plc | Antibodies and uses thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004050834A2 (en) * | 2002-11-27 | 2004-06-17 | Genpath Pharmaceuticals, Incorporated | GPC99 AND GPC99a: METHODS AND COMPOSITIONS FOR TREATING CANCER |
| WO2007045927A2 (en) * | 2005-10-18 | 2007-04-26 | University Of Sheffield | Therapeutic agent |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030055231A1 (en) * | 1998-10-28 | 2003-03-20 | Jian Ni | 12 human secreted proteins |
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2008
- 2008-04-23 AU AU2008244074A patent/AU2008244074B2/en not_active Ceased
- 2008-04-23 US US12/597,269 patent/US8389237B2/en not_active Expired - Fee Related
- 2008-04-23 ES ES08750480T patent/ES2393938T3/es active Active
- 2008-04-23 CA CA002685099A patent/CA2685099A1/en not_active Abandoned
- 2008-04-23 WO PCT/GB2008/001454 patent/WO2008132453A1/en not_active Ceased
- 2008-04-23 EP EP08750480A patent/EP2152753B1/en not_active Not-in-force
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- 2008-04-23 CN CN200880013626A patent/CN101842390A/zh active Pending
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004050834A2 (en) * | 2002-11-27 | 2004-06-17 | Genpath Pharmaceuticals, Incorporated | GPC99 AND GPC99a: METHODS AND COMPOSITIONS FOR TREATING CANCER |
| WO2007045927A2 (en) * | 2005-10-18 | 2007-04-26 | University Of Sheffield | Therapeutic agent |
Non-Patent Citations (2)
| Title |
|---|
| http://www.scbt.com/table.php?table=ramp. * February 2007 * |
| KELEG, S. et al International Journal of Cancer, Vol. 121, page 21-32). 8 February 2007 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014204724A (ja) | 2014-10-30 |
| AU2008244074A1 (en) | 2008-11-06 |
| ES2393938T3 (es) | 2013-01-02 |
| US20130189285A1 (en) | 2013-07-25 |
| US8389237B2 (en) | 2013-03-05 |
| EP2152753A1 (en) | 2010-02-17 |
| GB0708002D0 (en) | 2007-06-06 |
| JP2010524489A (ja) | 2010-07-22 |
| CA2685099A1 (en) | 2008-11-06 |
| CN101842390A (zh) | 2010-09-22 |
| KR20100015915A (ko) | 2010-02-12 |
| JP6086495B2 (ja) | 2017-03-01 |
| US20100111932A1 (en) | 2010-05-06 |
| EP2152753B1 (en) | 2012-08-08 |
| WO2008132453A1 (en) | 2008-11-06 |
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