AU2008232413B2 - Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) - Google Patents
Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Download PDFInfo
- Publication number
- AU2008232413B2 AU2008232413B2 AU2008232413A AU2008232413A AU2008232413B2 AU 2008232413 B2 AU2008232413 B2 AU 2008232413B2 AU 2008232413 A AU2008232413 A AU 2008232413A AU 2008232413 A AU2008232413 A AU 2008232413A AU 2008232413 B2 AU2008232413 B2 AU 2008232413B2
- Authority
- AU
- Australia
- Prior art keywords
- cartridge
- nitrogen dioxide
- kit
- gas
- flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims abstract description 557
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 title claims abstract description 67
- MGWGWNFMUOTEHG-UHFFFAOYSA-N 4-(3,5-dimethylphenyl)-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CC(C=2N=C(N)SC=2)=C1 MGWGWNFMUOTEHG-UHFFFAOYSA-N 0.000 title claims abstract description 59
- 238000006243 chemical reaction Methods 0.000 title description 27
- 239000007789 gas Substances 0.000 claims abstract description 176
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 68
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 65
- 239000011149 active material Substances 0.000 claims abstract description 45
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 39
- 239000000741 silica gel Substances 0.000 claims abstract description 36
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 36
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 7
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- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 claims description 6
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- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 19
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- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 2
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- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B21/00—Nitrogen; Compounds thereof
- C01B21/20—Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
- C01B21/24—Nitric oxide (NO)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
- A61M2016/102—Measuring a parameter of the content of the delivered gas
- A61M2016/1025—Measuring a parameter of the content of the delivered gas the O2 concentration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
- A61M2202/0275—Nitric oxide [NO]
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013267074A AU2013267074B2 (en) | 2007-03-23 | 2013-12-06 | Conversion of Nitrogen Dioxide (NO2) to Nitric Oxide (NO) |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89662707P | 2007-03-23 | 2007-03-23 | |
| US60/896,627 | 2007-03-23 | ||
| US95576707P | 2007-08-14 | 2007-08-14 | |
| US60/955,767 | 2007-08-14 | ||
| PCT/US2008/003739 WO2008118360A1 (en) | 2007-03-23 | 2008-03-21 | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013267074A Division AU2013267074B2 (en) | 2007-03-23 | 2013-12-06 | Conversion of Nitrogen Dioxide (NO2) to Nitric Oxide (NO) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2008232413A1 AU2008232413A1 (en) | 2008-10-02 |
| AU2008232413B2 true AU2008232413B2 (en) | 2013-09-19 |
Family
ID=39788824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2008232413A Active AU2008232413B2 (en) | 2007-03-23 | 2008-03-21 | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7947227B2 (OSRAM) |
| EP (1) | EP2131903B1 (OSRAM) |
| JP (2) | JP5575489B2 (OSRAM) |
| AU (1) | AU2008232413B2 (OSRAM) |
| CA (1) | CA2681308C (OSRAM) |
| WO (1) | WO2008118360A1 (OSRAM) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7618594B2 (en) | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| EP1789119B1 (en) | 2004-08-18 | 2017-10-18 | Geno LLC | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| JP5575489B2 (ja) * | 2007-03-23 | 2014-08-20 | ゲノ エルエルシー | 二酸化窒素（ｎｏ２）から酸化窒素（ｎｏ）への変換 |
| AU2009209181B2 (en) | 2008-01-28 | 2014-01-16 | VERO Biotech LLC. | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US8434475B2 (en) * | 2008-01-31 | 2013-05-07 | Genosys, Inc. | Nitric oxide reactor and distributor apparatus and method |
| US8607785B2 (en) | 2008-08-21 | 2013-12-17 | Geno Llc | Systems and devices for generating nitric oxide |
| CA2737695C (en) | 2008-09-22 | 2018-10-23 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| LT3210644T (lt) * | 2009-05-27 | 2019-02-11 | Ino Therapeutics Llc | Įrenginiai, skirti sugraduoto vožtuvo ir hermetiško kanistro įrenginio sukabinimui be sandariklio |
| AU2010263098B2 (en) | 2009-06-22 | 2016-01-07 | VERO Biotech LLC. | Nitric oxide therapies |
| CA2788582C (en) * | 2010-02-01 | 2020-01-07 | Geno Llc | Nitric oxide delivery system |
| USD673654S1 (en) * | 2010-04-08 | 2013-01-01 | Bruce Santourian | Set of valve covers with coil brackets |
| US8268252B2 (en) | 2010-04-26 | 2012-09-18 | Geno Llc | Nitrosyl special connector |
| WO2011137124A1 (en) * | 2010-04-26 | 2011-11-03 | Geno Llc | Delivery of ultra pure nitric oxide (no) |
| WO2012038853A1 (en) * | 2010-09-22 | 2012-03-29 | Koninklijke Philips Electronics N.V. | Method for generating nitric oxide |
| USD670360S1 (en) * | 2010-09-23 | 2012-11-06 | Specialty Auto Parts U.S.A., Inc. | Valve cover |
| WO2012075420A1 (en) | 2010-12-03 | 2012-06-07 | Geno Llc | Nitric oxide treatments |
| JP2014527025A (ja) | 2011-05-27 | 2014-10-09 | ゲノ エルエルシー | 吸入用一酸化窒素を用いて血管反応性を決定する方法 |
| EP3391891A3 (en) * | 2011-06-10 | 2019-01-02 | VERO Biotech LLC | Pressurized vessel of nitric oxide (no) |
| JP2016500550A (ja) * | 2012-11-05 | 2016-01-14 | ゲノ エルエルシー | 一酸化窒素を含むガスを混合する方法 |
| US9795756B2 (en) | 2012-12-04 | 2017-10-24 | Mallinckrodt Hospital Products IP Limited | Cannula for minimizing dilution of dosing during nitric oxide delivery |
| IL277164B2 (en) | 2012-12-04 | 2023-12-01 | Mallinckrodt Hospital Products Ip Ltd | A system for providing oxygenated nitrogen |
| US20140318658A1 (en) * | 2013-04-26 | 2014-10-30 | Real Sensors, Inc. | Useful Life of Permeation Devices |
| US10517817B2 (en) | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
| US10525226B2 (en) * | 2014-05-14 | 2020-01-07 | Mallinckrodt Hospital Products IP Limited | Systems and methods for indicating lifetime of an NO2-to-NO reactor cartridge used to deliver NO for inhalation therapy to a patient |
| US10213572B2 (en) * | 2014-10-20 | 2019-02-26 | Vero Biotech LLC | Nitrogen dioxide storage cassette |
| WO2017132275A1 (en) | 2016-01-27 | 2017-08-03 | Syk Technologies, Llc | Nitric oxide topical application apparatus and methods |
| TWI619539B (zh) | 2016-10-14 | 2018-04-01 | 財團法人工業技術研究院 | 淨化含氮氧化物氣體的組成物及裝置 |
| CN113456966A (zh) | 2017-02-27 | 2021-10-01 | 第三极股份有限公司 | 用于移动生成一氧化氮的系统和方法 |
| MX2020010523A (es) | 2017-02-27 | 2021-02-09 | Third Pole Inc | Sistemas y metodos para generar oxido nitrico. |
| KR102354762B1 (ko) | 2017-02-27 | 2022-01-25 | 써드 폴, 아이엔씨. | 산화 질소 발생 시스템 및 방법 |
| EP4285977A3 (en) | 2017-06-08 | 2024-02-14 | Case Western Reserve University | Vaporization system for delivery in a controlled concentration |
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- 2008-03-21 EP EP08742186.3A patent/EP2131903B1/en active Active
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Also Published As
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| US7947227B2 (en) | 2011-05-24 |
| US20110240020A1 (en) | 2011-10-06 |
| EP2131903B1 (en) | 2018-01-24 |
| JP2010522130A (ja) | 2010-07-01 |
| CA2681308C (en) | 2015-11-24 |
| EP2131903A1 (en) | 2009-12-16 |
| US8211368B2 (en) | 2012-07-03 |
| WO2008118360A1 (en) | 2008-10-02 |
| JP5575489B2 (ja) | 2014-08-20 |
| EP2131903A4 (en) | 2013-06-26 |
| AU2008232413A1 (en) | 2008-10-02 |
| US20080317874A1 (en) | 2008-12-25 |
| JP2015013118A (ja) | 2015-01-22 |
| CA2681308A1 (en) | 2008-10-02 |
| JP5950965B2 (ja) | 2016-07-13 |
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