AU2008222967B2 - Cross-linking of antioxidant-containing polymers - Google Patents

Cross-linking of antioxidant-containing polymers Download PDF

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Publication number
AU2008222967B2
AU2008222967B2 AU2008222967A AU2008222967A AU2008222967B2 AU 2008222967 B2 AU2008222967 B2 AU 2008222967B2 AU 2008222967 A AU2008222967 A AU 2008222967A AU 2008222967 A AU2008222967 A AU 2008222967A AU 2008222967 B2 AU2008222967 B2 AU 2008222967B2
Authority
AU
Australia
Prior art keywords
polymeric material
irradiation
antioxidant
temperature
irradiated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008222967A
Other languages
English (en)
Other versions
AU2008222967A1 (en
AU2008222967A8 (en
Inventor
Orhun K. Muratoglu
Stephen H. Spiegelberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Cambridge Polymer Group Inc
Original Assignee
General Hospital Corp
Cambridge Polymer Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp, Cambridge Polymer Group Inc filed Critical General Hospital Corp
Publication of AU2008222967A1 publication Critical patent/AU2008222967A1/en
Publication of AU2008222967A8 publication Critical patent/AU2008222967A8/en
Application granted granted Critical
Publication of AU2008222967B2 publication Critical patent/AU2008222967B2/en
Priority to AU2013200723A priority Critical patent/AU2013200723B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/505—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/143—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/20—Compounding polymers with additives, e.g. colouring
    • C08J3/22—Compounding polymers with additives, e.g. colouring using masterbatch techniques
    • C08J3/226—Compounding polymers with additives, e.g. colouring using masterbatch techniques using a polymer as a carrier
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C08J3/247—Heating methods
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/28—Treatment by wave energy or particle radiation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C71/00—After-treatment of articles without altering their shape; Apparatus therefor
    • B29C71/02—Thermal after-treatment
    • B29C2071/022—Annealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
    • B29K2023/04—Polymers of ethylene
    • B29K2023/06—PE, i.e. polyethylene
    • B29K2023/0658—PE, i.e. polyethylene characterised by its molecular weight
    • B29K2023/0683—UHMWPE, i.e. ultra high molecular weight polyethylene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/04—Homopolymers or copolymers of ethene
    • C08J2323/06—Polyethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2423/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K2201/00—Specific properties of additives
    • C08K2201/012—Additives improving oxygen scavenging properties

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Prostheses (AREA)
AU2008222967A 2007-03-02 2008-03-03 Cross-linking of antioxidant-containing polymers Ceased AU2008222967B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013200723A AU2013200723B2 (en) 2007-03-02 2013-02-07 Cross-linking of antioxidant-containing polymers

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US89268207P 2007-03-02 2007-03-02
US60/892,682 2007-03-02
US91516907P 2007-05-01 2007-05-01
US60/915,169 2007-05-01
PCT/US2008/055643 WO2008109515A1 (en) 2007-03-02 2008-03-03 Cross-linking of antioxidant-containing polymers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013200723A Division AU2013200723B2 (en) 2007-03-02 2013-02-07 Cross-linking of antioxidant-containing polymers

Publications (3)

Publication Number Publication Date
AU2008222967A1 AU2008222967A1 (en) 2008-09-12
AU2008222967A8 AU2008222967A8 (en) 2012-10-25
AU2008222967B2 true AU2008222967B2 (en) 2012-12-13

Family

ID=39733713

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008222967A Ceased AU2008222967B2 (en) 2007-03-02 2008-03-03 Cross-linking of antioxidant-containing polymers

Country Status (6)

Country Link
US (2) US9441081B2 (cg-RX-API-DMAC7.html)
EP (1) EP2125906A4 (cg-RX-API-DMAC7.html)
JP (1) JP2010529213A (cg-RX-API-DMAC7.html)
AU (1) AU2008222967B2 (cg-RX-API-DMAC7.html)
CA (1) CA2679274C (cg-RX-API-DMAC7.html)
WO (1) WO2008109515A1 (cg-RX-API-DMAC7.html)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8865788B2 (en) * 1996-02-13 2014-10-21 The General Hospital Corporation Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices
US8563623B2 (en) 1996-02-13 2013-10-22 The General Hospital Corporation Radiation melt treated ultra high molecular weight polyethylene prosthetic devices
US8262976B2 (en) * 2004-10-07 2012-09-11 Biomet Manufacturing Corp. Solid state deformation processing of crosslinked high molecular weight polymeric materials
US7344672B2 (en) 2004-10-07 2008-03-18 Biomet Manufacturing Corp. Solid state deformation processing of crosslinked high molecular weight polymeric materials
EP2277561B1 (en) * 2005-08-18 2012-09-19 Zimmer GmbH Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
JP5535650B2 (ja) * 2007-01-25 2014-07-02 ザ・ジェネラル・ホスピタル・コーポレイション 耐酸化性架橋重合体状材料の製造方法
ATE544476T1 (de) * 2007-04-10 2012-02-15 Zimmer Inc Antioxidans-stabilisiertes vernetztes ultrahochmolekulares polyethylen für anwendungen in medizinprodukten
US8664290B2 (en) 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
US8641959B2 (en) 2007-07-27 2014-02-04 Biomet Manufacturing, Llc Antioxidant doping of crosslinked polymers to form non-eluting bearing components
WO2009032909A2 (en) * 2007-09-04 2009-03-12 Smith & Nephew Orthopaedics Ag Ultra high molecular weight polyethylene for bearing surfaces
CA2712559C (en) 2008-01-30 2015-03-31 Zimmer, Inc. Orthopedic component of low stiffness
CN102216381B (zh) * 2008-04-24 2016-06-15 麦德托尼克公司 可再水化的多糖颗粒和海绵体
JP5311457B2 (ja) * 2008-06-20 2013-10-09 ナカシマメディカル株式会社 人工関節用摺動部材の成形方法及びこの方法によって成形された人工関節用摺動部材
GB0812890D0 (en) * 2008-07-11 2008-08-20 Smith & Nephew Orthopaedics Ag Compositions and methods of making compositions
EP2346941A1 (en) * 2008-11-20 2011-07-27 Zimmer GmbH Polyethylene materials
US8933145B2 (en) 2009-02-20 2015-01-13 The General Hospital Corporation High temperature melting
JP5902083B2 (ja) * 2009-05-04 2016-04-13 スミス アンド ネフュー インコーポレーテッド Ｕｈｍｗｐｅにおける複数の添加剤のブレンドによる相乗効果
WO2010135526A2 (en) * 2009-05-20 2010-11-25 The General Hospital Corporation Methods of preventing oxidation
DE102009023651B4 (de) * 2009-05-26 2021-07-01 Aesculap Ag Verfahren zur Herstellung eines mit einem Stabilisator dotierten Polyethylens und Verwendung eines nach diesem Verfahren hergestellten Polyethylens
JP4806717B2 (ja) * 2009-06-25 2011-11-02 株式会社沖データ 画像処理システム
GB0922339D0 (en) 2009-12-21 2010-02-03 Mcminn Derek J W Acetabular cup prothesis and introducer thereof
US8399535B2 (en) 2010-06-10 2013-03-19 Zimmer, Inc. Polymer [[s]] compositions including an antioxidant
WO2012061499A1 (en) * 2010-11-03 2012-05-10 Zimmer, Inc. Polymer articles having chemically bonded agents and methods of making the same
US8966868B2 (en) * 2011-05-09 2015-03-03 Abbott Cardiovascular Systems Inc. Methods of stabilizing molecular weight of polymer stents after sterilization
EP2731522B1 (en) 2011-07-13 2017-11-15 The General Hospital Corporation d/b/a Massachusetts General Hospital Devices for knee joint replacement with anterior cruciate ligament substitution
US9889224B2 (en) * 2012-08-06 2018-02-13 The General Hospital Corporation Spatial control of additives by high temperature
AU2013323337B2 (en) 2012-09-27 2018-02-15 The General Hospital Corporation D/B/A Massachusetts General Hospital Femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants and methods of using femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants
JP6215834B2 (ja) * 2012-10-11 2017-10-18 帝人ナカシマメディカル株式会社 成形品の製造方法
US9586370B2 (en) 2013-08-15 2017-03-07 Biomet Manufacturing, Llc Method for making ultra high molecular weight polyethylene
EP3052562B1 (en) 2013-10-01 2017-11-08 Zimmer, Inc. Polymer compositions comprising one or more protected antioxidants
EP3058017A4 (en) 2013-10-17 2017-10-04 The General Hospital Corporation Peroxide cross-linking and high temperature melting
WO2015138137A1 (en) * 2014-03-12 2015-09-17 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
US10265891B2 (en) 2014-12-03 2019-04-23 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
US20160280863A1 (en) * 2015-03-25 2016-09-29 Zimmer, Inc. Melt-stabilized ultra high molecular weight antioxidant
WO2017083476A1 (en) 2015-11-12 2017-05-18 The General Hospital Corporation Methods of making therapeutic polymeric material
WO2019046243A2 (en) 2017-08-29 2019-03-07 The General Hospital Corporation UV-INITIATED REACTIONS IN POLYMERIC MATERIALS
US11376128B2 (en) 2018-12-31 2022-07-05 Depuy Ireland Unlimited Company Acetabular orthopaedic prosthesis and method
US11103367B2 (en) 2019-02-15 2021-08-31 Encore Medical, L.P. Acetabular liner
CN110075366A (zh) * 2019-04-01 2019-08-02 杨青青 一种生物可吸收抗氧化提拉美容线及其制备方法和应用
US12171666B2 (en) 2019-12-10 2024-12-24 Depuy Ireland Unlimited Company Metal reinforced acetabular shell liner
US11291549B2 (en) 2019-12-11 2022-04-05 Depuy Ireland Unlimited Company Ceramic acetabular shell liners with augments
US11628066B2 (en) 2019-12-11 2023-04-18 Depuy Ireland Unlimited Company Ceramic acetabular shell liner with a metal ring having a lead-in surface
US12083018B2 (en) 2020-09-18 2024-09-10 Globus Medical, Inc. Hip arthroplasty implants
US12053383B2 (en) 2020-09-18 2024-08-06 Globus Medical Inc. Hip arthroplasty implants
US11970600B2 (en) 2021-03-31 2024-04-30 The General Hospital Corporation Di-cumyl peroxide crosslinking of UHMWPE
US12376964B2 (en) 2021-04-30 2025-08-05 Depuy Ireland Unlimited Company Apparatus and method for locking an acetabular liner to an acetabular cup
US12042389B2 (en) 2021-04-30 2024-07-23 Depuy Ireland Unlimited Company Apparatus and method for installing an acetabular liner on an acetabular cup
CN119137207A (zh) * 2022-05-27 2024-12-13 三菱化学株式会社 树脂组合物、多层结构体、成型体和树脂组合物的制造方法
US20250332801A1 (en) * 2024-04-29 2025-10-30 Mitsubishi Chemical America, Inc. Method to prepare high temperature pressure annealed medical grade uhmwpe
CN118652538B (zh) * 2024-08-13 2024-10-25 天津泽希矿产加工有限公司 一种彩色铝矾土防滑颗粒制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040156879A1 (en) * 2003-01-16 2004-08-12 Muratoglu Orhun K. Methods for making oxidation resistant polymeric material
US7166650B2 (en) * 2002-01-04 2007-01-23 Massachusetts General Hospital High modulus crosslinked polyethylene with reduced residual free radical concentration prepared below the melt

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5286772A (en) 1992-11-27 1994-02-15 The University Of Utah Synergistic compositions for the prevention of polymer degradation
US5879400A (en) 1996-02-13 1999-03-09 Massachusetts Institute Of Technology Melt-irradiated ultra high molecular weight polyethylene prosthetic devices
RU2211008C2 (ru) 1996-02-13 2003-08-27 Массачусетс Институт Оф Текнолоджи Протезные устройства из полиэтилена сверхвысокой молекулярной массы, обработанного облучением и плавлением
US5827904A (en) 1996-09-27 1998-10-27 Hahn; David Medical implant composition
US6017975A (en) * 1996-10-02 2000-01-25 Saum; Kenneth Ashley Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance
SE9900519D0 (sv) * 1999-02-17 1999-02-17 Lars Lidgren A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof
AU6108301A (en) 2000-04-27 2001-11-07 Orthopaedic Hospital Oxidation-resistant and wear-resistant polyethylenes for human joint replacements and methods for making them
WO2002026464A1 (en) 2000-09-29 2002-04-04 Depuy Orthopaedics, Inc. Supercritical fluid treatment of irradiated polyethylene
US20040048958A1 (en) * 2002-09-06 2004-03-11 Didier David A. High temperature ultra high molecular weight polyethylene
AT412969B (de) * 2003-05-19 2005-09-26 Klaus Dr Lederer Vernetztes, ultra-hochmolekulares polyethylen (uhmw-pe)
WO2005074619A2 (en) * 2004-02-03 2005-08-18 Massachusetts General Hospital Highly crystalline cross-linked oxidation-resistant polyethylene
US7833452B2 (en) * 2004-05-11 2010-11-16 The General Hospital Corporation Method for making oxidation resistant polymeric material
EP2277561B1 (en) * 2005-08-18 2012-09-19 Zimmer GmbH Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
ES2372742T3 (es) 2005-08-22 2012-01-26 The General Hospital Corporation Dba Massachusetts General Hospital Material polimérico homogeneizado resistente a oxidación.
EP2016118A4 (en) * 2005-08-22 2009-05-06 Gen Hospital Corp HIGH-NETWORK AND WEAR-RESISTANT POLYETHYLENE MANUFACTURED UNDER THE MELT
EP2441780A1 (en) * 2005-08-22 2012-04-18 The General Hospital Corporation d/b/a Massachusetts General Hospital Highly Crystalline Polyethylene
JP5283383B2 (ja) * 2005-09-28 2013-09-04 東レバッテリーセパレータフィルム株式会社 ポリエチレン微多孔膜の製造方法及び電池用セパレータ
JP5535650B2 (ja) * 2007-01-25 2014-07-02 ザ・ジェネラル・ホスピタル・コーポレイション 耐酸化性架橋重合体状材料の製造方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166650B2 (en) * 2002-01-04 2007-01-23 Massachusetts General Hospital High modulus crosslinked polyethylene with reduced residual free radical concentration prepared below the melt
US20040156879A1 (en) * 2003-01-16 2004-08-12 Muratoglu Orhun K. Methods for making oxidation resistant polymeric material

Also Published As

Publication number Publication date
CA2679274C (en) 2018-02-20
WO2008109515A1 (en) 2008-09-12
JP2010529213A (ja) 2010-08-26
US9441081B2 (en) 2016-09-13
US9962463B2 (en) 2018-05-08
EP2125906A4 (en) 2014-07-16
AU2008222967A1 (en) 2008-09-12
CA2679274A1 (en) 2008-09-12
US20160296661A1 (en) 2016-10-13
US20080215142A1 (en) 2008-09-04
EP2125906A1 (en) 2009-12-02
AU2008222967A8 (en) 2012-10-25

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