AU2008219115A1 - Substituted fused-ring compounds for inflammation and immune-related uses - Google Patents

Substituted fused-ring compounds for inflammation and immune-related uses Download PDF

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Publication number
AU2008219115A1
AU2008219115A1 AU2008219115A AU2008219115A AU2008219115A1 AU 2008219115 A1 AU2008219115 A1 AU 2008219115A1 AU 2008219115 A AU2008219115 A AU 2008219115A AU 2008219115 A AU2008219115 A AU 2008219115A AU 2008219115 A1 AU2008219115 A1 AU 2008219115A1
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optionally substituted
compound
subject
pct
alkyl
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AU2008219115A
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Gary Bohnert
Shoujun Chen
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Synta Phamaceuticals Corp
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Synta Phamaceuticals Corp
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    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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  • Neurology (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
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  • Ophthalmology & Optometry (AREA)
AU2008219115A 2007-02-16 2008-02-15 Substituted fused-ring compounds for inflammation and immune-related uses Abandoned AU2008219115A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90194907P 2007-02-16 2007-02-16
US60/901,949 2007-02-16
PCT/US2008/002077 WO2008103310A1 (en) 2007-02-16 2008-02-15 Substituted fused-ring compounds for inflammation and immune-related uses

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Publication Number Publication Date
AU2008219115A1 true AU2008219115A1 (en) 2008-08-28

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AU2008219115A Abandoned AU2008219115A1 (en) 2007-02-16 2008-02-15 Substituted fused-ring compounds for inflammation and immune-related uses

Country Status (7)

Country Link
US (1) US8809396B2 (OSRAM)
EP (1) EP2129219A4 (OSRAM)
JP (1) JP2010519206A (OSRAM)
AU (1) AU2008219115A1 (OSRAM)
CA (1) CA2678615A1 (OSRAM)
TW (1) TW200901961A (OSRAM)
WO (1) WO2008103310A1 (OSRAM)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2595000C (en) 2005-01-25 2013-10-15 Synta Pharmaceuticals Corp. Thiophene compounds for inflammation and immune-related uses
EP1998612A4 (en) 2006-01-25 2010-11-24 Synta Pharmaceuticals Corp SUBSTITUTED BIARYL COMPOUNDS FOR USE AGAINST INFLAMMATION AND IMMUNE DISORDERS
WO2007087441A2 (en) 2006-01-25 2007-08-02 Synta Pharmaceuticals Corp. Substituted aromatic compounds for inflammation and immune-related uses
JP2009524683A (ja) 2006-01-25 2009-07-02 シンタ ファーマシューティカルズ コーポレーション 炎症および免疫関連用途のためのビニル−フェニル誘導体
WO2007109362A2 (en) 2006-03-20 2007-09-27 Synta Pharmaceuticals Corp. Benzoimidazolyl-parazine compounds for inflammation and immune-related uses
US8779154B2 (en) 2006-09-26 2014-07-15 Qinglin Che Fused ring compounds for inflammation and immune-related uses
US8993612B2 (en) 2009-10-08 2015-03-31 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer
US8377970B2 (en) 2009-10-08 2013-02-19 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel
PT2563776T (pt) 2010-04-27 2016-09-19 Calcimedica Inc Compostos que modulam o cálcio intracelular
CA2797533A1 (en) 2010-04-27 2011-11-10 Calcimedica, Inc. Compounds that modulate intracellular calcium
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9079891B2 (en) 2010-08-27 2015-07-14 Calcimedica, Inc. Compounds that modulate intracellular calcium
US20120316182A1 (en) 2011-06-10 2012-12-13 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9856240B2 (en) 2011-10-19 2018-01-02 Calcimedica, Inc. Compounds that modulate intracellular calcium
ES2748022T3 (es) * 2011-11-21 2020-03-12 Univ Tsukuba Modulador de la actividad, medicamento que comprende el mismo, uso de ratón deficiente del gen de CD300a y anticuerpo antiCD300a
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9850309B2 (en) 2012-11-07 2017-12-26 University Of Tsukuba Medicament comprising activity modulator for CD300a-expressing cell associated with allergic disease, CD300a gene-deficient mouse, and use of activity modulator for CD300a-expressing cell
CA2978007A1 (en) 2015-02-27 2016-09-01 Calcimedica, Inc. Pancreatitis treatment
DK3331525T3 (da) 2015-08-07 2020-12-14 Calcimedica Inc Anvendelse af CRAC-kanal-inhibitorer til behandling af slagtilfælde og traumatisk hjerneskade
US20230242640A1 (en) * 2018-08-22 2023-08-03 Ose Immunotherapeutics ANTI-SIRPg Compounds
JP2022508468A (ja) 2018-09-14 2022-01-19 ルヒゼン ファーマスティカルズ アクツィエンゲゼルシャフト Ｃｒａｃ阻害剤およびコルチコステロイドを含む組成物ならびにそれらの使用方法
JP7744350B2 (ja) 2020-01-13 2025-09-25 バージ アナリティクス，インコーポレイテッド 置換ピラゾロ－ピリミジンおよびその使用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1793518A1 (de) * 1964-10-02 1972-02-03 Searle & Co Verfahren zur Herstellung von 1-Vinyltetralolen
PT87487B (pt) 1987-05-15 1992-09-30 Schering Corp Processo para a preparacao de derivados de naftaleno, benzoxepina, benzazepina e benzociclo-hepteno
WO1997048672A2 (en) * 1996-06-21 1997-12-24 Allergan Sales, Inc. Substituted tetrahydronaphthalene and dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
DE19805370A1 (de) * 1997-03-14 1998-09-17 Gruenenthal Gmbh Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen
DE19833786A1 (de) 1998-07-18 2000-01-20 Schering Ag Benzocycloheptene, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
WO2000027802A1 (en) * 1998-11-12 2000-05-18 Ariad Pharmaceuticals, Inc. Bicyclic signal transduction inhibitors, compositions containing them & uses thereof
WO2000037429A2 (en) 1998-12-22 2000-06-29 Tanabe Seiyaku Co., Ltd. INHIBITORS OF α4β1 MEDIATED CELL ADHESION
US6608101B1 (en) 2000-06-20 2003-08-19 Atherogenics, Inc. 1, 3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders
JP2004002402A (ja) * 2002-04-24 2004-01-08 Takeda Chem Ind Ltd Ｃｃｒ拮抗作用を有する化合物の用途
EP1498125A4 (en) * 2002-04-24 2008-08-20 Takeda Pharmaceutical USE OF COMPOUNDS WITH CCR ANTAGONISM
JP2004196702A (ja) * 2002-12-18 2004-07-15 Yamanouchi Pharmaceut Co Ltd 新規なアミド誘導体又はその塩
ES2222833B1 (es) 2003-07-30 2006-03-01 Laboratorios Del Dr. Esteve, S.A. Compuestos piperidinicos 1,4-disustituidos, su preparacion y su uso como medicamentos.
DE102004044680B3 (de) * 2004-09-09 2006-06-08 Schering Ag Alkyliden-Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer sowie diese enthaltende pharmazeutische Präparate
WO2006065842A2 (en) * 2004-12-13 2006-06-22 Synta Pharmaceuticals Corp. 5,6,7,8-tetrahydroquinolines and related compounds and uses thereof
US7863270B2 (en) * 2005-05-13 2011-01-04 Synta Pharmaceuticals Corp. IL-12 modulatory compounds

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US8809396B2 (en) 2014-08-19
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