AU2007224275B2 - Method and device for treating microscopic residual tumors remaining in tissues following surgical resection - Google Patents

Method and device for treating microscopic residual tumors remaining in tissues following surgical resection Download PDF

Info

Publication number
AU2007224275B2
AU2007224275B2 AU2007224275A AU2007224275A AU2007224275B2 AU 2007224275 B2 AU2007224275 B2 AU 2007224275B2 AU 2007224275 A AU2007224275 A AU 2007224275A AU 2007224275 A AU2007224275 A AU 2007224275A AU 2007224275 B2 AU2007224275 B2 AU 2007224275B2
Authority
AU
Australia
Prior art keywords
tumor
tissue
bleomycin
agent
marginal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007224275A
Other languages
English (en)
Other versions
AU2007224275A1 (en
Inventor
Paul Goldfarb
Dietmar Rabussay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grand Decade Developments Ltd
Original Assignee
Grand Decade Developments Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grand Decade Developments Ltd filed Critical Grand Decade Developments Ltd
Publication of AU2007224275A1 publication Critical patent/AU2007224275A1/en
Priority to AU2012201850A priority Critical patent/AU2012201850B2/en
Application granted granted Critical
Publication of AU2007224275B2 publication Critical patent/AU2007224275B2/en
Assigned to ONCOSEC MEDICAL INCORPORATED reassignment ONCOSEC MEDICAL INCORPORATED Request for Assignment Assignors: GENETRONICS, INC.
Assigned to GRAND DECADE DEVELOPMENTS LIMITED reassignment GRAND DECADE DEVELOPMENTS LIMITED Request for Assignment Assignors: ONCOSEC MEDICAL INCORPORATED
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Surgical Instruments (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2007224275A 2006-03-03 2007-03-02 Method and device for treating microscopic residual tumors remaining in tissues following surgical resection Ceased AU2007224275B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012201850A AU2012201850B2 (en) 2006-03-03 2012-03-29 Method and device for treating microscopic residual tumors remaining in tissues following surgical resection

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77874006P 2006-03-03 2006-03-03
US60/778,740 2006-03-03
PCT/US2007/005133 WO2007103070A2 (en) 2006-03-03 2007-03-02 Method and device for treating microscopic residual tumors remaining in tissues following surgical resection

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012201850A Division AU2012201850B2 (en) 2006-03-03 2012-03-29 Method and device for treating microscopic residual tumors remaining in tissues following surgical resection

Publications (2)

Publication Number Publication Date
AU2007224275A1 AU2007224275A1 (en) 2007-09-13
AU2007224275B2 true AU2007224275B2 (en) 2012-04-12

Family

ID=38475369

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007224275A Ceased AU2007224275B2 (en) 2006-03-03 2007-03-02 Method and device for treating microscopic residual tumors remaining in tissues following surgical resection

Country Status (12)

Country Link
US (4) US9037230B2 (cg-RX-API-DMAC7.html)
EP (2) EP3845269A1 (cg-RX-API-DMAC7.html)
JP (3) JP2009528131A (cg-RX-API-DMAC7.html)
KR (2) KR101529448B1 (cg-RX-API-DMAC7.html)
CN (2) CN101426550B (cg-RX-API-DMAC7.html)
AU (1) AU2007224275B2 (cg-RX-API-DMAC7.html)
CA (1) CA2644163C (cg-RX-API-DMAC7.html)
DK (1) DK1991303T3 (cg-RX-API-DMAC7.html)
ES (1) ES2874482T3 (cg-RX-API-DMAC7.html)
NO (2) NO344476B1 (cg-RX-API-DMAC7.html)
PL (1) PL1991303T3 (cg-RX-API-DMAC7.html)
WO (1) WO2007103070A2 (cg-RX-API-DMAC7.html)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007103070A2 (en) 2006-03-03 2007-09-13 Genetronics, Inc. Method and device for treating microscopic residual tumors remaining in tissues following surgical resection
SG183726A1 (en) 2007-08-14 2012-09-27 Hutchinson Fred Cancer Res Needle array assembly and method for delivering therapeutic agents
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
CA2722296A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US10448989B2 (en) 2009-04-09 2019-10-22 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US9173704B2 (en) * 2008-06-20 2015-11-03 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
US8632534B2 (en) 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
CA2689400C (en) * 2009-12-30 2023-01-10 Kenneth W. Adams Therapeutic agent delivery apparatus and process
KR101952155B1 (ko) 2010-04-28 2019-02-26 이노비오 파마수티컬즈, 인크. 구강 점막 전기천공 장치 및 그 용도
EP2627274B1 (en) 2010-10-13 2022-12-14 AngioDynamics, Inc. System for electrically ablating tissue of a patient
US9457183B2 (en) 2011-06-15 2016-10-04 Tripep Ab Injection needle and device
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
AU2012328457A1 (en) 2011-10-28 2014-04-24 Presage Biosciences, Inc. Methods for drug delivery
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
CN106715682A (zh) 2014-05-12 2017-05-24 弗吉尼亚暨州立大学知识产权公司 使用脉冲电场选择性调节细胞的胞内影响
US12114911B2 (en) 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
US10287543B2 (en) * 2015-11-19 2019-05-14 Miltenyi Biotec, Gmbh Process and device for isolating cells from biological tissue
US20170232253A1 (en) * 2016-02-16 2017-08-17 Marcy C. Purnell Bioelectrodynamics Modulation Method
CN114098949B (zh) 2016-06-27 2023-12-19 盖能适治疗股份有限公司 发生器和具有电极的导管
US12403305B2 (en) 2016-06-27 2025-09-02 Galvanize Therapeutics, Inc. Immunostimulation in the treatment of viral infection
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
CA3082568A1 (en) 2017-11-15 2019-05-23 Alcyone Lifesciences, Inc. Therapy specific, pre-programmed auto injection device
EP3710102A4 (en) * 2017-11-17 2021-08-04 AbbVie Inc. METHOD OF TREATMENT OF GLIOBLASTOMA
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
CN111683613B (zh) 2017-12-26 2024-05-28 盖能适治疗股份有限公司 用于各种应用的能量输送的优化
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US12390262B2 (en) 2018-03-13 2025-08-19 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
TWI850282B (zh) 2018-11-27 2024-08-01 香港商弘年發展有限公司 用於治療癌症之質體建構體和使用方法
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
JP7586890B2 (ja) 2019-07-16 2024-11-19 ガルヴァナイズ セラピューティクス，インコーポレイテッド パルス電界による生殖器の治療
US12214189B2 (en) 2019-07-24 2025-02-04 Virginia Tech Intellectual Properties, Inc. Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies
US12485279B2 (en) 2020-11-25 2025-12-02 Virginia Tech Intellectual Properties, Inc. Methods for modulating temporal infrastructure of pulsed electric fields
CN116509535B (zh) * 2023-03-14 2024-01-23 武汉金柏威光电技术有限公司 一种医用高频电刀

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030097089A1 (en) * 1993-04-01 2003-05-22 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US20050054969A1 (en) * 2001-03-13 2005-03-10 University Of South Florida Electromanipulation Device and Method
US20050089511A1 (en) * 1991-03-06 2005-04-28 Roth Jack A. Methods and compositions comprising DNA damaging agents and p53
US20050142112A1 (en) * 1997-02-18 2005-06-30 Canji, Inc. Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
US20060024358A1 (en) * 2004-07-30 2006-02-02 Santini John T Jr Multi-reservoir device for transdermal drug delivery and sensing

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5702359A (en) 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
ATE290403T1 (de) 1997-06-30 2005-03-15 Roussy Inst Gustave Verbesserung der verabreichung der nukleinsäure in zellen der plurizellulären eukaryotischen organismen und kombination zur durchführung des verfahrens
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
WO1999037538A2 (en) 1998-01-26 1999-07-29 Simula Inc. Parachute landing velocity attenuator
US6208893B1 (en) 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6104584A (en) * 1999-02-18 2000-08-15 Lucent Technologies, Inc. Voltage feedback inrush current limit circuit having increased tolerance for component value variation
AU2590201A (en) * 1999-12-23 2001-07-03 Human Genome Sciences, Inc. Trefoil domain-containing polynucleotides, polypeptides, and antibodies
JP4987205B2 (ja) 2000-03-03 2012-07-25 ジェネトロニクス， インコーポレイテッド 遺伝子送達用核酸製剤および使用方法
US6428504B1 (en) 2000-04-06 2002-08-06 Varian Medical Systems, Inc. Multipurpose template and needles for the delivery and monitoring of multiple minimally invasive therapies
US20040092860A1 (en) * 2000-07-26 2004-05-13 Dev Nagendu B. Skin and muscle-targeted gene therapy by pulsed electrical field
AU2002360648B2 (en) * 2001-12-14 2009-01-08 Genetronics, Inc. Methods for particle-assisted polynucleotide immunization using a pulsed electric field
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
AU2003230601A1 (en) * 2002-03-07 2003-09-22 Instituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Clinical syringe with electrical stimulation aspects
ATE519499T1 (de) * 2002-05-10 2011-08-15 Agennix Inc Lactoferrin bei der behandlung maligner neoplasien und anderer hyperproliferativer erkrankungen
US20040014645A1 (en) * 2002-05-28 2004-01-22 Advisys, Inc. Increased delivery of a nucleic acid construct in vivo by the poly-L-glutamate ("PLG") system
JP4409239B2 (ja) * 2003-09-18 2010-02-03 テルモ株式会社 薬液注入装置
US7234824B2 (en) * 2003-09-22 2007-06-26 Langley Nicholas M Glare-elimination device for surgical microscopes
US20050209625A1 (en) * 2004-03-02 2005-09-22 Chan Frank A Method and apparatus for electrical stimulation to enhance lancing device performance
US20070088345A1 (en) 2005-10-13 2007-04-19 Ust Inc. Applications of HIFU and chemotherapy
WO2007103070A2 (en) 2006-03-03 2007-09-13 Genetronics, Inc. Method and device for treating microscopic residual tumors remaining in tissues following surgical resection
US7671095B2 (en) * 2006-05-31 2010-03-02 The Trustees Of The Boston University Films and particles
PT3524316T (pt) * 2006-10-17 2024-11-29 Inovio Pharmaceuticals Inc Dispositivos de eletroporação para eletroporação de células em mamíferos

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050089511A1 (en) * 1991-03-06 2005-04-28 Roth Jack A. Methods and compositions comprising DNA damaging agents and p53
US20030097089A1 (en) * 1993-04-01 2003-05-22 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US20050142112A1 (en) * 1997-02-18 2005-06-30 Canji, Inc. Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
US20050054969A1 (en) * 2001-03-13 2005-03-10 University Of South Florida Electromanipulation Device and Method
US20060024358A1 (en) * 2004-07-30 2006-02-02 Santini John T Jr Multi-reservoir device for transdermal drug delivery and sensing

Also Published As

Publication number Publication date
US20120143120A1 (en) 2012-06-07
CN102921102A (zh) 2013-02-13
CA2644163C (en) 2020-05-05
US20210308451A1 (en) 2021-10-07
DK1991303T3 (da) 2021-06-07
EP3845269A1 (en) 2021-07-07
CN102921102B (zh) 2015-06-10
CN101426550A (zh) 2009-05-06
KR20090004890A (ko) 2009-01-12
ES2874482T3 (es) 2021-11-05
US12324913B2 (en) 2025-06-10
JP2009528131A (ja) 2009-08-06
CN101426550B (zh) 2012-10-31
US9037230B2 (en) 2015-05-19
KR20140081894A (ko) 2014-07-01
AU2007224275A1 (en) 2007-09-13
NO20191102A1 (no) 2008-11-13
WO2007103070A2 (en) 2007-09-13
KR101529448B1 (ko) 2015-06-18
PL1991303T3 (pl) 2021-10-11
EP1991303A2 (en) 2008-11-19
EP1991303A4 (en) 2012-01-18
KR101444471B1 (ko) 2014-09-24
JP2013127000A (ja) 2013-06-27
JP6174632B2 (ja) 2017-08-02
NO20084148L (no) 2008-11-13
US11007365B2 (en) 2021-05-18
US20170216585A1 (en) 2017-08-03
CA2644163A1 (en) 2007-09-13
US20070239099A1 (en) 2007-10-11
JP2015213778A (ja) 2015-12-03
WO2007103070A3 (en) 2008-08-28
NO344476B1 (no) 2020-01-13
EP1991303B1 (en) 2021-05-05

Similar Documents

Publication Publication Date Title
US12324913B2 (en) Method and device for treating microscopic residual tumors remaining in tissues following surgical resection
Panje et al. Electroporation therapy of head and neck cancer
JP2025185047A (ja) がんの免疫学的処置
US10252004B2 (en) Method and apparatus for delivery of therapeutic agents
US9861829B2 (en) Cold plasma electroporation of medication and associated methods
Rangel et al. Electrochemotherapy in the treatment of neoplasms in dogs and cats
AU4177100A (en) Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
HK40046842A (en) Method and device for treating microscopic residual tumors remaining in tissues following surgical resection
AU2012201850A1 (en) Method and device for treating microscopic residual tumors remaining in tissues following surgical resection
Heller et al. Medical Applications
Deore et al. Elecrochemotherapy: An enhancement of cytotoxicity of anticancer drugs
Möller et al. The Role of Electrochemotherapy in the Treatment of Malignant Melanoma

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: ONCOSEC MEDICAL INCORPORATED

Free format text: FORMER OWNER(S): GENETRONICS, INC.

PC Assignment registered

Owner name: GRAND DECADE DEVELOPMENTS LIMITED

Free format text: FORMER OWNER(S): ONCOSEC MEDICAL INCORPORATED

MK14 Patent ceased section 143(a) (annual fees not paid) or expired