AU2006256369B2 - Novel salts of conjugated psychotropic drugs and processes of preparing same - Google Patents

Novel salts of conjugated psychotropic drugs and processes of preparing same Download PDF

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Publication number
AU2006256369B2
AU2006256369B2 AU2006256369A AU2006256369A AU2006256369B2 AU 2006256369 B2 AU2006256369 B2 AU 2006256369B2 AU 2006256369 A AU2006256369 A AU 2006256369A AU 2006256369 A AU2006256369 A AU 2006256369A AU 2006256369 B2 AU2006256369 B2 AU 2006256369B2
Authority
AU
Australia
Prior art keywords
residue
chemical
acid
conjugate
addition salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006256369A
Other languages
English (en)
Other versions
AU2006256369A1 (en
AU2006256369A8 (en
Inventor
Eran J. Benjamin
Irit Gil-Ad
Shlomit Halachmi
Abraham Nudelman
Ada Rephaeli
Abraham Weizman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ramot at Tel Aviv University Ltd
Bar Ilan University
BiolineRx Ltd
Original Assignee
Ramot at Tel Aviv University Ltd
Bar Ilan University
BiolineRx Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ramot at Tel Aviv University Ltd, Bar Ilan University, BiolineRx Ltd filed Critical Ramot at Tel Aviv University Ltd
Publication of AU2006256369A1 publication Critical patent/AU2006256369A1/en
Publication of AU2006256369A8 publication Critical patent/AU2006256369A8/en
Application granted granted Critical
Publication of AU2006256369B2 publication Critical patent/AU2006256369B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
    • C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
AU2006256369A 2005-06-07 2006-06-07 Novel salts of conjugated psychotropic drugs and processes of preparing same Ceased AU2006256369B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68785105P 2005-06-07 2005-06-07
US60/687,851 2005-06-07
US79450106P 2006-04-25 2006-04-25
US60/794,501 2006-04-25
PCT/IL2006/000666 WO2006131923A2 (en) 2005-06-07 2006-06-07 Novel salts of conjugated psychotropic drugs and processes of preparing same

Publications (3)

Publication Number Publication Date
AU2006256369A1 AU2006256369A1 (en) 2006-12-14
AU2006256369A8 AU2006256369A8 (en) 2006-12-14
AU2006256369B2 true AU2006256369B2 (en) 2012-08-02

Family

ID=37033348

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006256369A Ceased AU2006256369B2 (en) 2005-06-07 2006-06-07 Novel salts of conjugated psychotropic drugs and processes of preparing same

Country Status (8)

Country Link
US (1) US20090298814A1 (https=)
EP (1) EP1888120B1 (https=)
JP (1) JP5284779B2 (https=)
AU (1) AU2006256369B2 (https=)
CA (1) CA2610838A1 (https=)
ES (1) ES2400772T3 (https=)
MX (1) MX2007015511A (https=)
WO (1) WO2006131923A2 (https=)

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US7544681B2 (en) 2001-09-27 2009-06-09 Ramot At Tel Aviv University Ltd. Conjugated psychotropic drugs and uses thereof
CN101506188B (zh) * 2006-06-22 2014-01-15 雷蒙特亚特特拉维夫大学有限公司 作为具外周系统限制活性药物的五羟色胺再摄取抑制剂
US9278947B2 (en) 2006-06-22 2016-03-08 Ramot At Tel-Aviv University Ltd. Serotonin reuptake inhibitors as drugs having peripheral-system-restricted activity
EP2051735B1 (en) 2006-07-17 2012-08-29 Ramot, at Tel Aviv University Ltd. Conjugates comprising a psychotropic drug or a gaba agonist and an organic acid and their use treating pain and other cns disorders
WO2009101616A1 (en) 2008-02-11 2009-08-20 Ramot At Tel Aviv University Ltd. Novel conjugates for treating neurodegenerative diseases and disorders
WO2011070579A1 (en) * 2009-12-09 2011-06-16 Biolinerx Ltd. Methods of improving cognitive functions
US8377929B2 (en) * 2010-02-24 2013-02-19 Ramot At Tel-Aviv University Ltd. Crystalline forms of the tri-mesylate salt of perphenazine-GABA and process of producing the same
WO2012038963A1 (en) 2010-09-22 2012-03-29 Ramot At Tel-Aviv University Ltd. An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
CN105358530A (zh) * 2013-06-10 2016-02-24 美国安进公司 制备mdm2抑制剂的方法及其结晶形式
US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
KR20220009954A (ko) 2019-04-17 2022-01-25 컴퍼스 패쓰파인더 리미티드 신경인지 장애, 만성 통증을 치료하고 염증을 감소시키는 방법

Citations (1)

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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003026563A2 (en) * 2001-09-27 2003-04-03 Ramot At Tel Aviv University Ltd. Conjugated anti-psychotic drugs and uses thereof

Also Published As

Publication number Publication date
JP2008545777A (ja) 2008-12-18
JP5284779B2 (ja) 2013-09-11
WO2006131923A3 (en) 2007-08-02
MX2007015511A (es) 2008-03-06
EP1888120A2 (en) 2008-02-20
EP1888120B1 (en) 2012-12-05
WO2006131923A2 (en) 2006-12-14
ES2400772T3 (es) 2013-04-12
AU2006256369A1 (en) 2006-12-14
US20090298814A1 (en) 2009-12-03
CA2610838A1 (en) 2006-12-14
AU2006256369A8 (en) 2006-12-14

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Legal Events

Date Code Title Description
TH Corrigenda

Free format text: IN VOL 22, NO 5, PAGE(S) 486 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE -NAME INDEX UNDER THE NAME BIOLINERX LTD., APPLICATION NO. 2006256369, UNDER INID (71), ADD APPLICANTS BAR-ILAN UNIVER SITY AND RAMOT AT TEL AVIV UNIVERSITY LTD.

TH Corrigenda

Free format text: IN VOL 22, NO 5, PAGE(S) 486 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE -NAME INDEX UNDER THE NAME RAMOT AT TEL AVIV UNIVERSITY LTD., BAR-ILAN UNIVERSITY AND BIOLINERX LTD., APPLICATION NO. 2006256369, UNDER INID (71), CORRECT THE NAME TO RAMOT AT TEL AVIV UNIVERSITY LTD., BAR-ILAN UNIVERSITY AND BIOLINERX LTD.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired