AU2006248812B2 - Antifungal agents - Google Patents

Antifungal agents Download PDF

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Publication number
AU2006248812B2
AU2006248812B2 AU2006248812A AU2006248812A AU2006248812B2 AU 2006248812 B2 AU2006248812 B2 AU 2006248812B2 AU 2006248812 A AU2006248812 A AU 2006248812A AU 2006248812 A AU2006248812 A AU 2006248812A AU 2006248812 B2 AU2006248812 B2 AU 2006248812B2
Authority
AU
Australia
Prior art keywords
phenyl
oxo
indolizin
acetamide
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006248812A
Other languages
English (en)
Other versions
AU2006248812A1 (en
Inventor
Nigel Mark Allanson
Gareth Morse Davies
Rhian Teresa Davies
Philip Neil Edwards
Alexandre Kuvshinov
Samantha Patricia Thomson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F2G Ltd
Original Assignee
F2G Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0510190A external-priority patent/GB0510190D0/en
Priority claimed from GB0607841A external-priority patent/GB0607841D0/en
Application filed by F2G Ltd filed Critical F2G Ltd
Publication of AU2006248812A1 publication Critical patent/AU2006248812A1/en
Application granted granted Critical
Publication of AU2006248812B2 publication Critical patent/AU2006248812B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2006248812A 2005-05-18 2006-05-18 Antifungal agents Ceased AU2006248812B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0510190A GB0510190D0 (en) 2005-05-18 2005-05-18 Antifungal agents
GB0510190.2 2005-05-18
GB0607841.4 2006-04-20
GB0607841A GB0607841D0 (en) 2006-04-20 2006-04-20 Antifungal agents
PCT/GB2006/001820 WO2006123145A1 (en) 2005-05-18 2006-05-18 Antifungal agents

Publications (2)

Publication Number Publication Date
AU2006248812A1 AU2006248812A1 (en) 2006-11-23
AU2006248812B2 true AU2006248812B2 (en) 2012-02-16

Family

ID=36763577

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006248812A Ceased AU2006248812B2 (en) 2005-05-18 2006-05-18 Antifungal agents

Country Status (11)

Country Link
US (1) US8486962B2 (enExample)
EP (1) EP1888063B1 (enExample)
JP (1) JP5172661B2 (enExample)
AT (1) ATE420639T1 (enExample)
AU (1) AU2006248812B2 (enExample)
CA (1) CA2608977C (enExample)
DE (1) DE602006004865D1 (enExample)
DK (1) DK1888063T3 (enExample)
ES (1) ES2321230T3 (enExample)
NZ (1) NZ563397A (enExample)
WO (1) WO2006123145A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0623209D0 (en) * 2006-11-21 2007-01-03 F2G Ltd Antifungal agents
GB0710121D0 (en) * 2007-05-25 2007-07-04 F2G Ltd Antifungal agents
DE102007037579B4 (de) 2007-08-09 2012-05-16 Emc Microcollections Gmbh Neue Benzimidazol-2-yl-alkylamine und ihre Anwendung als mikrobizide Wirkstoffe
CN101168532B (zh) * 2007-11-30 2010-06-02 中科院嘉兴中心应用化学分中心 一种n-甲基哌嗪取代苯胺的合成方法
PL2283006T3 (pl) 2008-04-24 2015-08-31 F2G Ltd Pirolowe środki przeciwgrzybicze
GB0809773D0 (en) * 2008-05-29 2008-07-09 F2G Ltd Antifungal combination therapy
US20130102631A1 (en) 2010-07-02 2013-04-25 Syngenta Crop Protection Llc Novel microbiocidal dioxime ether derivatives
AR082405A1 (es) 2010-07-29 2012-12-05 Syngenta Participations Ag Derivados microbicidas de eteres de dioximas
EP2619181A1 (en) 2010-09-23 2013-07-31 Syngenta Participations AG Novel microbiocides
EP2638011A1 (en) 2010-11-12 2013-09-18 Syngenta Participations AG Novel microbiocides
WO2012117021A2 (en) 2011-03-03 2012-09-07 Syngenta Participations Ag Novel microbiocidal oxime ethers
AR087609A1 (es) 2011-08-23 2014-04-03 Syngenta Participations Ag Microbiocidas
WO2013092460A1 (en) 2011-12-20 2013-06-27 Syngenta Participations Ag Cyclic bisoxime microbicides
US20150025105A1 (en) * 2012-02-09 2015-01-22 Praveen Rao Perampalli Nekkar Indolizine derivatives
EP2641901A1 (en) 2012-03-22 2013-09-25 Syngenta Participations AG. Novel microbiocides
CN102964256B (zh) * 2012-11-28 2014-05-07 浙江海翔药业股份有限公司 一种4-氨基-n,n-二甲基苄胺的制备方法
CN104744302A (zh) * 2013-12-31 2015-07-01 上海药谷药业有限公司 一种2-(4-氨基苯基)-2-甲基丙腈化合物的制备方法
EP3415511A1 (en) * 2014-11-21 2018-12-19 F2G Limited Antifungal agents
GB201609222D0 (en) 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection
CN112898316A (zh) * 2019-12-03 2021-06-04 微境生物医药科技(上海)有限公司 新型吡咯化合物
CN114644634B (zh) * 2020-12-21 2023-06-20 深圳市祥根生物医药有限公司 一种吡咯衍生物及其制备方法和用途
CN114031502A (zh) * 2021-10-09 2022-02-11 南京一苇医药科技有限公司 一种对硝基苯丙酮的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003383A1 (en) * 1994-07-21 1996-02-08 Eli Lilly And Company INDOLIZINE sPLA2 INHIBITORS
WO2002098876A1 (en) * 2001-06-06 2002-12-12 Vertex Pharmaceuticals Incorporated Cak inhibitors and uses thereof
WO2004082606A2 (en) * 2003-03-13 2004-09-30 Synta Pharmaceuticals Corp. Fused pyrrole compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003383A1 (en) * 1994-07-21 1996-02-08 Eli Lilly And Company INDOLIZINE sPLA2 INHIBITORS
US6645976B1 (en) * 1994-07-21 2003-11-11 Eli Lilly And Company Indolizine SPLA2inhibitors
WO2002098876A1 (en) * 2001-06-06 2002-12-12 Vertex Pharmaceuticals Incorporated Cak inhibitors and uses thereof
WO2004082606A2 (en) * 2003-03-13 2004-09-30 Synta Pharmaceuticals Corp. Fused pyrrole compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Hagishita, S. et al, Journal of Medicinal Chemistry, 1996, 39(19):3636-3658 *

Also Published As

Publication number Publication date
US20080161302A1 (en) 2008-07-03
ATE420639T1 (de) 2009-01-15
CA2608977C (en) 2014-09-23
JP5172661B2 (ja) 2013-03-27
AU2006248812A1 (en) 2006-11-23
ES2321230T3 (es) 2009-06-03
DK1888063T3 (da) 2009-05-11
WO2006123145A1 (en) 2006-11-23
EP1888063B1 (en) 2009-01-14
DE602006004865D1 (de) 2009-03-05
NZ563397A (en) 2010-04-30
CA2608977A1 (en) 2006-11-23
JP2008545647A (ja) 2008-12-18
US8486962B2 (en) 2013-07-16
EP1888063A1 (en) 2008-02-20

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired