AU2006200795A1 - Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport - Google Patents

Description

P001 Section 29 Regulation 3.2(2)

AUSTRALIA

Patents Act 1990 COMPLETE SPECIFICATION STANDARD PATENT Application Number: Lodged: Invention Title: Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport The following statement is a full description of this invention, including the best method of performing it known to me us: -1- CORYNEBACTERIUM GLUTAMICUM GENES ENCODING PROTEINS INVOLVED IN MEMBRANE SYNTHESIS AND MEMBRANE TRANSPORT Related Applications This application claims priority to prior filed U.S. Provisional Patent Application Serial No. 60/141031, filed June 25, 1999. This application also claims priority to German Patent Application No. 19931454.3, filed July 8, 1999, German Patent Application No. 19931478.0, filed July 8, 1999, German Patent Application No.

19931563.9, filed July 8, 1999, German Patent Application No. 19932122.1, filed July 9, 1999, German Patent Application No. 19932124.8, filed 99709, German Patent Application No. 19932125.6, filed July 9, 1999, German Patent Application No.

19932128.0, filed July 9, 1999, German Patent Application No. 19932180.9, filed July 9, 1999, German Patent Application No. 19932182.5, filed July 9, 1999, German Patent Application No. 19932190.6, filed July 9, 1999, German Patent Application No.

19932191.4, filed July 9, 1999, German Patent Application No. 19932209.0, filed July 9, 1999, German Patent Application No. 19932212.0, filed July 9, 1999, German Patent Application No. 19932227.9, filed July 9, 1999, German Patent Application No.

19932228.7, filed July 9, 1999, German Patent Application No. 19932229.5, filed 99070, German Patent Application No. 19932230.9, filed July 9, 1999, German Patent Application No. 19932927.3, filed July 14, 1999, German Patent Application No.

19933005.0, filed July 14, 1999, German Patent Application No. 19933006.9, filed July 14, 1999, German Patent Application No. 19940764.9, filed August 27, 1999, German Patent Application No. 19940765.7, filed August 27, 1999, German Patent Application No. 19940766.5, filed August 27, 1999, German Patent Application No. 19940830.0, filed August 27, 1999, German Patent Application No. 19940831.9, filed August 27, 1999, German Patent Application No. 19940832.7, filed August 27, 1999, German Patent Application No. 19940833.5, filed August 27, 1999, German Patent Application No. 19941378.9 filed August 31, 1999, German Patent Application No. 19941379.7, filed August 31, 1999, German Patent Application No. 19941395.9, filed August 31, 1999, German Patent Application No. 19942077.7, filed September 3, 1999, German Patent Application No. 19942078.5, filed September 3, 1999, German Patent Application No. 19942079.3, filed September 3, 1999, and German Patent Application No. 19942088.2, filed September 3, 1999. The entire contents of all of the above referenced applications are hereby expressly incorporated herein by this reference.

Background of the Invention Certain products and by-products of naturally-occurring metabolic processes in cells have utility in a wide array of industries, including the food, feed, cosmetics, and pharmaceutical industries. These molecules, collectively termed 'fine chemicals', include organic acids, both proteinogenic and non-proteinogenic amino acids, nucleotides and nucleosides, lipids and fatty acids, diols, carbohydrates, aromatic compounds, vitamins and cofactors, and enzymes. Their production is most conveniently performed through the large-scale culture of bacteria developed to produce and secrete large quantities of one or more desired molecules. One particularly useful organism for this purpose is Corynehacterium glutamicum, a gram positive, nonpathogenic bacterium. Through strain selection, a number of mutant strains have been developed which produce an array of desirable compounds. However, selection of strains improved for the production of a particular molecule is a time-consuming and difficult process.

Summary of the Invention The invention provides novel bacterial nucleic acid molecules which have a variety of uses. These uses include the identification of microorganisms which can be used to produce fine chemicals, the modulation of fine chemical production in C.

glutamicum or related bacteria, the typing or identification of C. glutamicum or related bacteria, as reference points for mapping the C. glutamicum genome, and as markers for transformation. These novel nucleic acid molecules encode proteins, referred to herein as membrane construction and membrane transport (MCT) proteins.

C. glutamicum is a gram positive, aerobic bacterium which is commonly used in industry for the large-scale production of a variety of fine chemicals, and also for the degradation of hydrocarbons (such as in petroleum spills) and for the oxidation of terpenoids. The MCT nucleic acid molecules of the invention, therefore, can be used to identify microorganisms which can be used to produce fine chemicals, by -3fermentation processes. Modulation of the expression of the MCT nucleic acids of the invention, or modification of the sequence of the MCT nucleic acid molecules of the invention, can be used to modulate the production of one or more fine chemicals from a microorganism to improve the yield or production of one or more fine chemicals from a Corynebacterium or Brevibacterium species).

The MCT nucleic acids of the invention may also be used to identify an organism as being Corynebacterium glutamicum or a close relative thereof, or to identify the presence of C. glutamicum or a relative thereof in a mixed population of microorganisms. The invention provides the nucleic acid sequences of a number of C.

glutamicum genes; by probing the extracted genomic DNA of a culture of a unique or mixed population of microorganisms under stringent conditions with a probe spanning a region of a C. glutamicum gene which is unique to this organism, one can ascertain whether this organism is present. Although Corynebacterium glutamicum itself is nonpathogenic, it is related to species pathogenic in humans, such as Corynebacterium diphtheriae (the causative agent of diphtheria); the detection of such organisms is of significant clinical relevance.

The MCT nucleic acid molecules of the invention may also serve as reference points for mapping of the C. glutamicum genome, or of genomes of related organisms.

Similarly, these molecules, or variants or portions thereof, may serve as markers for genetically engineered Corynebacterium or Brevibacterium species.

The MCT proteins encoded by the novel nucleic acid molecules of the invention are capable of, for example, performing a function involved in the metabolism the biosynthesis or degradation) of compounds necessary for membrane biosynthesis, or of assisting in the transmembrane transport of one or more compounds either into or out of the cell. Given the availability of cloning vectors for use in Corynebacterium glutamicum, such as those disclosed in Sinskey et al., U.S. Patent No. 4,649,119, and techniques for genetic manipulation of C. glutamicum and the related Brevibacterium species lactofermentum) (Yoshihama et al, J. Bacteriol. 162: 591-597 (1985); Katsumata et J Bacteriol. 159: 306-311 (1984); and Santamaria et al., J. Gen.

Microbiol. 130: 2237-2246 (1984)), the nucleic acid molecules of the invention may be utilized in the genetic engineering of this organism to make it a better or more efficient producer of one or more fine chemicals. This improved production or efficiency of -4production of a fine chemical may be due to a direct effect of manipulation of a gene of the invention, or it may be due to an indirect effect of such manipulation.

There are a number of mechanisms by which the alteration of an MCT protein of the invention may directly affect the yield, production, and/or efficiency of production of a fine chemical from a C. glutamicum strain incorporating such an altered protein.

Those MCT proteins involved in the export of fine chemical molecules from the cell may be increased in number or activity such that greater quantities of these compounds are secreted to the extracellular medium, from which they are more readily recovered.

Similarly, those MCT proteins involved in the import of nutrients necessary for the biosynthesis of one or more fine chemicals phosphate, sulfate, nitrogen compounds, etc.) may be increased in number or activity such that these precursors, cofactors, or intermediate compounds are increased in concentration within the cell.

Further, fatty acids and lipids themselves are desirable fine chemicals; by optimizing the activity or increasing the number of one or more MCT proteins of the invention which participate in the biosynthesis of these compounds, or by impairing the activity of one or more MCT proteins which are involved in the degradation of these compounds, it may be possible to increase the yield, production, and/or efficiency of production of fatty acid and lipid molecules from C. glutamicum.

The mutagenesis of one or more MCT genes of the invention may also result in MCT proteins having altered activities which indirectly impact the production of one or more desired fine chemicals from C .glutamicum. For example, MCT proteins of the invention involved in the export of waste products may be increased in number or activity such that the normal metabolic wastes of the cell (possibly increased in quantity due to the overproduction of the desired fine chemical) are efficiently exported before they are able to damage nucleotides and proteins within the cell (which would decrease the viability of the cell) or to interfere with fine chemical biosynthetic pathways (which would decrease the yield, production, or efficiency of production of the desired fine chemical). Further, the relatively large intracellular quantities of the desired fine chemical may in itself be toxic to the cell, so by increasing the activity or number of transporters able to export this compound from the cell, one may increase the viability of the cell in culture, in turn leading to a greater number of cells in.the culture producing the desired fine chemical. The MCT proteins of the invention may also be manipulated such that the relative amounts of different lipid and fatty acid molecules are produced. This may have a profound effect on the lipid composition of the membrane of the cell. Since each type of lipid has different physical properties, an alteration in the lipid composition of a membrane may significantly alter membrane fluidity. Changes in membrane fluidity can impact the transport of molecules across the membrane, as well as the integrity of the cell, both of which have a profound effect on the production of fine chemicals from C. glutamicum in large-scale fermentative culture.

The invention provides novel nucleic acid molecules which encode proteins, referred to herein as MCT proteins, which are capable of, for example, participating in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. Nucleic acid molecules encoding an MCT protein are referred to herein as MCT nucleic acid molecules. In a preferred embodiment, the MCT protein participates in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. Examples of such proteins include those encoded by the genes set forth in Table 1.

The following embodiments, the subject of the invention of this application are specifically disclosed herein: An isolated Corynebacterium glutamicum nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of each of the odd numbered SEQ ID NOs: 7 to 675, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof.

An isolated nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence selected from the group consisting of each of the even numbered SEQ ID NOs: 8 to 676, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof.

An isolated nucleic acid molecule which encodes a naturally occurring allelic variant of a polypeptide comprising an amino acid sequence selected from the group consisting of each of the even numbered SEQ ID NOs: 8 to 676, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof.

An isolated nucleic acid molecule comprising a nucleotide sequence which is at least 50% identical to the entire nucleotide sequence of any of the odd numbered SEQ ID NOs: 7 to 675, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof.

An isolated nucleic acid molecule comprising a fragment of at least contiguous nucleotides of the nucleotide sequence of any of the odd numbered SEQ ID NOs: 7 to 675, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof.

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of each of the even numbered SEQ ID NOs: 8 to 676, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1.

An isolated polypeptide comprising a naturally occurring allelic variant of a polypeptide comprising an amino acid sequence selected from the group consisting of each of the even numbered SEQ ID NOs: 8 to 676, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1.

An isolated polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least identical to the entire nucleic acid sequence of any of the odd numbered SEQ ID NOs: 7 to 675, provided that the nucleic acid molecule does not consist of any of the F-designated nucleic acid molecules set forth in Table 1.

An isolated polypeptide comprising an amino acid sequence which is at least 50% identical to the entire amino acid sequence of any of the even numbered SEQ ID NOs: 8 to 676, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1.

An isolated polypeptide comprising a fragment of a polypeptide comprising the amino acid sequence of any of the even numbered SEQ ID NOs: 8 to 676, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1, wherein said polypeptide fragment maintains a biological activity of the polypeptide comprising the amino sequence.

A host cell comprising a nucleic acid molecule selected from the group consisting of each of the odd numbered SEQ ID NOs: 7 to 675, wherein the nucleic acid molecule is disrupted.

A host cell comprising a nucleic acid molecule selected from the group consisting of each of the odd numbered SEQ ID NOs: 7 to 675, wherein the nucleic acid molecule comprises one or more nucleic acid modifications as compared to the sequence set forth in any of the odd-numbered SEQ ID NOs: 7 to 675.

A host cell comprising a nucleic acid molecule selected from the group consisting of each of the odd numbered SEQ ID NOs: 7 to 675, wherein the regulatory region of the nucleic acid molecule is modified relative to the wild-type regulatory region of the molecule.

Accordingly, one aspect of the invention pertains to isolated nucleic acid molecules cDNAs, DNAs, or RNAs) comprising a nucleotide sequence encoding an MCT protein or biologically active portions thereof, as well as nucleic acid fragments suitable as primers or hybridization probes for the detection or amplification of MCT encoding nucleic acid DNA or mRNA). In particularly preferred embodiments, the isolated nucleic acid molecule comprises one of the nucleotide sequences set forth as the odd-numbered SEQ ID NOs in the Sequence Listing SEQ ID NO:I, SEQ ID NO:3, SEQ ID NO:5, SEQ ID forth as the odd-numbered SEQ ID NOs in the Sequence Listing SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID or the coding region or a complement thereof of one of these nucleotide sequences. In other particularly preferred embodiments, the isolated nucleic acid molecule of the invention comprises a nucleotide sequence which hybridizes to or is at least about 50%, preferably at least about 60%, more preferably at least about or 90%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to a nucleotide sequence set forth as an odd-numbered SEQ ID NO in the Sequence Listing SEQ ID NO:1, SEQ ID NO:3, SEQ ID SEQ ID or a portion thereof. In other preferred embodiments, the isolated nucleic acid molecule encodes one of the amino acid sequences set forth as an even-numbered SEQ ID NO in the Sequence Listing SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID The preferred MCT proteins of the present invention also preferably possess at least one of the MCT activities described herein.

In another embodiment, the isolated nucleic acid molecule encodes a protein or portion thereof wherein the protein or portion thereof includes an amino acid sequence which is sufficiently homologous to an amino acid sequence of the invention a sequence having an even-numbered SEQ ID NO: in the Sequence Listing), e.g., sufficiently homologous to an amino acid sequence of the invention such that the protein or portion thereof maintains an MCT activity. Preferably; the protein or portion thereof encoded by the nucleic acid molecule maintains.the ability to participate in the metabolism of compounds necessary for the construction of cellular membranes in C.

glutamicum, or in the transport of molecules across these membranes. In one embodiment, the protein encoded by the nucleic acid molecule is at least about preferably at least about 60%, and more preferably at least about 70%, 80%, or 90% and most preferably at least about 95%, 96%, 97%, 98%, or 99% or more homologous to an amino acid sequence of the invention an entire amino acid sequence selected from those having an even-numbered SEQ ID NO in the Sequence Listing). In another preferred embodiment, the protein is a full length C. glutamicum protein which is substantially homologous to an entire amino acid sequence of the invention (encoded by an open reading frame shown in the corresponding odd-numbered SEQ ID NOs in the Sequence Listing SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID In another preferred embodiment, the isolated nucleic acid molecule is derived from C. glutamicum and encodes a protein an MCT fusion protein) which includes a biologically active domain which is at least about 50% or more homologous to one of the amino acid sequences of the invention a sequence of one of the even-numbered SEQ ID NOs in the Sequence Listing) and is able to participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or has one or more of the activities set forth in Table 1, and which also includes heterologous nucleic acid sequences encoding a heterologous polypeptide or regulatory regions.

In another embodiment, the isolated nucleic acid molecule is at least nucleotides in length and hybridizes under stringent conditions to a nucleic acid molecule comprising a nucleotide sequence of the invention a sequence of an oddnumbered SEQ ID NO in the Sequence Listing). Preferably, the isolated nucleic acid molecule corresponds to a naturally-occurring nucleic acid molecule. More preferably, the isolated nucleic acid encodes a naturally-occurring C. glutamicum MCT protein, or a biologically active portion thereof.

Another aspect of the invention pertains to vectors, recombinant expression vectors, containing the nucleic acid molecules of the invention, and host cells into which such vectors have been introduced. In one embodiment, such a host cell is used to produce an MCT protein by culturing the host cell in a suitable medium. The MCT protein can be then isolated from the medium or the host cell.

Yet another aspect of the invention pertains to a genetically altered microorganism in which an MCT gene has been introduced or altered. In one embodiment, the genome of the microorganism has been altered by introduction of a nucleic acid molecule of the invention encoding wild-type or mutated MCT sequence as a transgene. In another embodiment, an endogenous MCT gene within the genome of the microorganism has been altered, functionally disrupted, by homologous recombination with an altered MCT gene. In another embodiment, an endogenous or introduced MCT gene in a microorganism has been altered by one or more point mutations, deletions, or inversions, but still encodes a functional MCT protein. In still another embodiment, one or more of the regulatory regions a promoter, repressor, or inducer) of an MCT gene in a microorganism has been altered by deletion, truncation, inversion, or point mutation) such that the expression of the MCT gene is modulated. In a preferred embodiment, the microorganism belongs to the genus Corynebacterium or Brevibacterium, with Corynebacterium glutamicum being particularly preferred. In a preferred embodiment, the microorganism is also utilized for the production of a desired compound, such as an amino acid, with lysine being particularly preferred.

In another aspect, the invention provides a method of identifying the presence or activity of Cornyebacterium diphtheriae in a subject. This method includes detection of one or more of the nucleic acid or amino acid sequences of the invention the sequences set forth in the Sequence Listing as SEQ ID NOs 1 through 676) in a subject, thereby detecting the presence or activity of Corynebacterium diphtheriae in the subject.

Still another aspect of the invention pertains to an isolated MCT protein or a portion, a biologically active portion, thereof. In a preferred embodiment, the isolated MCT protein or portion thereof can participate in the metabolism of compounds necessary for the construction of cellular membranes in C glutamicum, or in the transport of molecules across these membranes. In another preferred embodiment, the isolated MCT protein or portion thereof is sufficiently homologous to an amino acid sequence of the invention a sequence of an even-numbered SEQ ID NO- in the Sequence Listing) such that the protein or portion thereof maintains the ability to participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes.

The invention also provides an isolated preparation of an MCT protein. In preferred embodiments, the MCT protein comprises an amino acid sequence of the invention a sequence of an even-numbered SEQ ID NO: of the Sequence Listing).

In another preferred embodiment, the invention pertains to an isolated full length protein which is substantially homologous to an entire amino acid sequence of the invention a sequence of an even-numbered SEQ ID NO: of the Sequence Listing) (encoded by an open reading frame set forth in a corresponding odd-numbered SEQ ID NO: of the Sequence Listing In yet another embodiment, the protein is at least about preferably at least about 60%, and more preferably at least about 70%, 80%, or and most preferably at least about 95%, 96%, 97%, 98%, or 99% or more homologous to an entire amino acid sequence of the invention a sequence of an even-numbered SEQ ID NO: of the Sequence Listing). In other embodiments, the isolated MCT protein comprises an amino acid sequence which is at least about 50% or more homologous to one of the amino acid sequences of the invention a sequence of an even-numbered SEQ ID NO: of the Sequence Listing) and is able to participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or has one or more of the activities set forth in Table 1.

Alternatively, the isolated MCT protein can comprise an amino acid sequence which is encoded by a nucleotide sequence which hybridizes, hybridizes under stringent conditions, or is at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80%, or 90%, and even more preferably at least about 96%, 97%, or 99% or more homologous, to a nucleotide sequence of one of the even-numbered SEQ 1D NOs set forth in the Sequence Listing. It is also preferred that the preferred forms of MCT proteins also have one or more of the MCT bioactivities described herein.

The MCT polypeptide, or a biologically active portion thereof, can be operatively linked to a non-MCT polypeptide to form a fusion protein. In preferred embodiments, this fusion protein has an activity which differs from that of the MCT protein alone. In other preferred embodiments, this fusion protein participate in the metabolism of compounds necessary for the construction of cellular membranes in C.

glutamicum, or in the transport of molecules across these membranes. In particularly preferred embodiments, integration of this fusion protein into a host cell modulates production of a desired compound from the cell.

In another aspect, the invention provides methods for screening molecules which modulate the activity of an MCT protein, either by interacting with the protein itself or a substrate or binding partner of the MCT protein, or by modulating the transcription or translation of an MCT nucleic acid molecule of the invention.

Another aspect of the invention pertains to a method for producing a fine chemical. This method involves the culturing of a cell containing a vector directing the expression of an MCT nucleic acid molecule of the invention, such that a fine chemical is produced. In a preferred embodiment, this method further includes the step of obtaining a cell containing such a vector, in which a cell is transfected with a vector directing the expression of an MCT nucleic acid. In another preferred embodiment, this method further includes the step of recovering the fine chemical from the culture. In a particularly preferred embodiment, the cell is from the genus Corynebacterium or Brevibacterium, or is selected from those strains set forth in Table 3.

Another aspect of the invention pertains to methods for modulating production of a molecule from a microorganism. Such methods include contacting the cell with an agent which modulates MCT protein activity or MCT nucleic acid expression such that a cell associated activity is altered relative to this same activity in the absence of the agent. In a preferred embodiment, the cell is modulated for one or more C. glutamicum metabolic pathways for cell membrane components or is modulated for the transport of compounds across such membranes, such that the yields or rate of production of a desired fine chemical by this microorganism is improved. The agent which modulates MCT protein activity can be an agent which stimulates MCT protein activity or MCT nucleic acid expression. Examples of agents which stimulate MCT protein activity or MCT nucleic acid expression include small molecules, active MCT proteins, and nucleic acids encoding MCT proteins that have been introduced into the cell. Examples of agents which inhibit MCT activity or expression include small molecules and antisense MCT nucleic acid molecules.

Another aspect of the invention pertains to methods for modulating yields of a desired compound from a cell, involving the introduction of a wild-type or mutant MCT gene into a cell, either maintained on a separate plasmid or integrated into the genome of the host cell. If integrated into the genome, such integration can be random, or it can take place by homologous recombination such that the native gene is replaced by the introduced copy, causing the production of the desired compound from the cell to be modulated. In a preferred embodiment, said yields are increased. In another preferred embodiment, said chemical is a fine chemical. In a particularly preferred embodiment, said fine chemical is an amino acid. In especially preferred embodiments, said amino acid is L-lysine.

Detailed Description of the Invention The present invention provides MCT nucleic acid and protein molecules which are involved in the metabolism of cellular membrane components in C. glutamicum or in the transport of compounds across such membranes. The molecules of the invention may be utilized in the modulation of production of fine chemicals from microorganisms, such as C. glutamicum, either directly where overexpression or optimization of a fatty acid biosynthesis protein has a direct impact on the yield, production, and/or efficiency of production of the fatty acid from modified C. glutamicum), or may have an indirect impact which nonetheless results in an increase of yield, production, and/or efficiency of production of the desired compound where modulation of the metabolism of cell membrane components results in alterations in the yield, production, -11and/or efficiency of production or the composition of the cell membrane, which in turn may impact the production of one or more fine chemicals). Aspects of the invention are further explicated below.

I. Fine Chemicals The term 'fine chemical' is art-recognized and includes molecules produced by an organism which have applications in various industries, such as, but not limited to, the pharmaceutical, agriculture, and cosmetics industries. Such compounds include organic acids, such as tartaric acid, itaconic acid, and diaminopimelic acid, both proteinogenic and non-proteinogenic amino acids, purine and pyrimidine bases, nucleosides, and nucleotides (as described e.g. in Kuninaka, A. (1996) Nucleotides and related compounds, p. 561-612, in Biotechnology vol. 6, Rehm et al., eds. VCH: Weinheim, and references contained therein), lipids, both saturated and unsaturated fatty acids arachidonic acid), diols propane diol, and butane diol), carbohydrates hyaluronic acid and trehalose), aromatic compounds aromatic amines, vanillin, and indigo), vitamins and cofactors (as described in Ullmann's Encyclopedia of Industrial Chemistry, vol. A27, "Vitamins", p. 443-613 (1996) VCH: Weinheim and references therein; and Ong, Niki, E. Packer, L. (1995) "Nutrition, Lipids, Health, and Disease" Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia, and the Society for Free Radical Research Asia, held Sept. 1-3, 1994 at Penang, Malaysia, AOCS Press, (1995)), enzymes, polyketides (Cane et al. (1998) Science 282: 63-68), and all other chemicals described in Gutcho (1983) Chemicals by Fermentation, Noyes Data Corporation, ISBN: 0818805086 and references therein. The metabolism and uses of certain of these fine chemicals are further explicated below.

A. Amino Acid Metabolism and Uses Amino acids comprise the basic structural units of all proteins, and as such are essential for normal cellular functioning in all organisms. The term "amino acid" is artrecognized. The proteinogenic amino acids, of which there are 20 species, serve as structural units for proteins, in which they are linked by peptide bonds, while the nonproteinogenic amino acids (hundreds of which are known) are not normally found in -12proteins (see Ulmann's Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97 VCH: Weinheim (1985)). Amino acids may be in the D- or L- optical configuration, though Lamino acids are generally the only type found in naturally-occurring proteins.

Biosynthetic and degradative pathways of each of the 20 proteinogenic amino acids have been well characterized in both prokaryotic and eukaryotic cells (see, for example, Stryer, L. Biochemistry, 3 rd edition, pages 578-590 (1988)). The 'essential' amino acids (histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine), so named because they are generally a nutritional requirement due to the complexity of their biosyntheses, are readily converted by simple biosynthetic pathways to the remaining 11 'nonessential' amino acids (alanine, arginine, asparagine, aspartate, cysteine, glutamate, glutamine, glycine, proline, serine, and tyrosine). Higher animals do retain the ability to synthesize some of these amino acids, but the essential amino acids must be supplied from the diet in order for normal protein synthesis to occur.

Aside from their function in protein biosynthesis, these amino acids are interesting chemicals in their own right, and many have been found to have various applications in the food, feed, chemical, cosmetics, agriculture, and pharmaceutical industries. Lysine is an important amino acid in the nutrition not only of humans, but also of monogastric animals such as poultry and swine. Glutamate is most commonly used as a flavor additive (mono-sodium glutamate, MSG) and is widely used throughout the food industry, as are aspartate, phenylalanine, glycine, and cysteine. Glycine, Lmethionine and tryptophan are all utilized in the pharmaceutical industry. Glutamine, valine, leucine, isoleucine, histidine, arginine, proline, serine and alanine are of use in both the pharmaceutical and cosmetics industries. Threonine, tryptophan, and D/ Lmethionine are common feed additives. (Leuchtenberger, W. (1996) Amino aids technical production and use, p. 466-502 in Rehm et al. (eds.) Biotechnology vol. 6, chapter 14a, VCH: Weinheim). Additionally, these amino acids have been found to be useful as precursors for the synthesis of synthetic amino acids and proteins, such as Nacetylcysteine, S-carboxymethyl-L-cysteine, (S)-5-hydroxytryptophan, and others described in Ulmann's Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97, VCH: Weinheim, 1985.

The biosynthesis of these natural amino acids in organisms capable of producing them, such as bacteria, has been well characterized (for review of bacterial 13amino acid biosynthesis and regulation thereof, see Umbarger, H.E.(1978) Ann. Rev.

Biochem. 47: 533-606). Glutamate is synthesized by the reductive amination of aketoglutarate, an intermediate in the citric acid cycle. Glutamine, proline, and arginine are each subsequently produced from glutamate. The biosynthesis of serine is a threestep process beginning with 3-phosphoglycerate (an intermediate in glycolysis), and resulting in this amino acid after oxidation, transamination, and hydrolysis steps. Both cysteine and glycine are produced from serine; the former by the condensation of homocysteine with serine, and the latter by the transferal of the side-chain p-carbon atom to tetrahydrofolate, in a reaction catalyzed by serine transhydroxymethylase.

Phenylalanine, and tyrosine are synthesized from the glycolytic and pentose phosphate pathway precursors erythrose 4-phosphate and phosphoenolpyruvate in a 9-step biosynthetic pathway that differ only at the final two steps after synthesis of prephenate.

Tryptophan is also produced from these two initial molecules, but its synthesis is an 11step pathway. Tyrosine may also be synthesized from phenylalanine, in a reaction catalyzed by phenylalanine hydroxylase. Alanine, valine, and leucine are all biosynthetic products of pyruvate, the final product of glycolysis. Aspartate is formed from oxaloacetate, an intermediate of the citric acid cycle. Asparagine, methionine, threonine, and lysine are each produced by the conversion of aspartate. Isoleucine is formed from threonine. A complex 9-step pathway results in the production of histidine from 5-phosphoribosyl-l-pyrophosphate, an activated sugar.

Amino acids in excess of the protein synthesis needs of the cell cannot be stored, and are instead degraded to provide intermediates for the major metabolic pathways of the cell (for review see Stryer, L. Biochemistry 3 rd ed. Ch. 21 "Amino Acid Degradation and the Urea Cycle" p. 495-516 (1988)). Although the cell is able to convert unwanted amino acids into useful metabolic intermediates, amino acid production is costly in terms of energy, precursor molecules, and the enzymes necessary to synthesize them.

Thus it is not surprising that amino acid biosynthesis is regulated by feedback inhibition, in which the presence of a particular amino acid serves to slow or entirely stop its own production (for overview of feedback mechanisms in amino acid biosynthetic pathways, see Stryer, L. Biochemistry, 3 rd ed. Ch. 24: "Biosynthesis of Amino Acids and Heme" p.

575-600 (1988)). Thus, the output of any particular amino acid is limited by the amount of that amino acid present in the cell.

-14- B. Vitamin, Cofactor, and Nutraceutical Metabolism and Uses Vitamins, cofactors, and nutraceuticals comprise another group of molecules which the higher animals have lost the ability to synthesize and so must ingest, although they are readily synthesized by other organisms such as bacteria. These molecules are either bioactive substances themselves, or are precursors of biologically active substances which may serve as electron carriers or intermediates in a variety of metabolic pathways. Aside from their nutritive value, these compounds also have significant industrial value as coloring agents, antioxidants, and catalysts or other processing aids. (For an overview of the structure, activity, and industrial applications of these compounds, see, for example, Ullman's Encyclopedia of Industrial Chemistry, "Vitamins" vol. A27, p. 443-613, VCH: Weinheim, 1996.) The term "vitamin" is artrecognized, and includes nutrients which are required by an organism for normal functioning, but which that organism cannot synthesize by itself. The group of vitamins may encompass cofactors and nutraceutical compounds. The language "cofactor" includes nonproteinaceous compounds required for a normal enzymatic activity to occur. Such compounds may be organic or inorganic; the cofactor molecules of the invention are preferably organic. The term "nutraceutical" includes dietary supplements having health benefits in plants and animals, particularly humans. Examples of such molecules are vitamins, antioxidants, and also certain lipids polyunsaturated fatty acids).

The biosynthesis of these molecules in organisms capable of producing them, such as bacteria, has been largely characterized (Ullman's Encyclopedia of Industrial Chemistry, "Vitamins" vol. A27, p. 443-613, VCH: Weinheim, 1996; Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley Sons; Ong, Niki, E. Packer, L. (1995) "Nutrition, Lipids, Health, and Disease" Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia, and the Society for Free Radical Research Asia, held Sept.

1-3, 1994 at Penang, Malaysia, AOCS Press: Champaign, IL X, 374 S).

Thiamin (vitamin Bi) is produced by the chemical coupling of pyrimidine and thiazole moieties. Riboflavin (vitamin B 2 is synthesized from (GTP) and ribose-5'-phosphate. Riboflavin, in turn, is utilized for the synthesis of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). The family of compounds collectively termed 'vitamin B 6 pyridoxine, pyridoxamine, pyridoxaand the commercially used pyridoxin hydrochloride) are all derivatives of the common structural unit, 5-hydroxy-6-methylpyridine. Pantothenate (pantothenic acid, (R)-(+)-N-(2,4-dihydroxy-3,3-dimethyl-l-oxobutyl)-p-alanine) can be produced either by chemical synthesis or by fermentation. The final steps in pantothenate biosynthesis consist of the ATP-driven condensation of p-alanine and pantoic acid. The enzymes responsible for the biosynthesis steps for the conversion to pantoic acid, to Palanine and for the condensation to panthotenic acid are known. The metabolically active form of pantothenate is Coenzyme A, for which the biosynthesis proceeds in enzymatic steps. Pantothenate, pyridoxal-5'-phosphate, cysteine and ATP are the precursors of Coenzyme A. These enzymes not only catalyze the formation of panthothante, but also the production of (R)-pantoic acid, (R)-pantolacton, panthenol (provitamin Bs), pantetheine (and its derivatives) and coenzyme A.

Biotin biosynthesis from the precursor molecule pimeloyl-CoA in microorganisms has been studied in detail and several of the genes involved have been identified. Many of the corresponding proteins have been found to also be involved in Fe-cluster synthesis and are members of the nifS class of proteins. Lipoic acid is derived from octanoic acid, and serves as a coenzyme in energy metabolism, where it becomes part of the pyruvate dehydrogenase complex and the a-ketoglutarate dehydrogenase complex. The folates are a group of substances which are all derivatives of folic acid, which is turn is derived from L-glutamic acid, p-amino-benzoic acid and 6methylpterin. The biosynthesis of folic acid and its derivatives, starting from the metabolism intermediates guanosine-5'-triphosphate (GTP), L-glutamic acid and pamino-benzoic acid has been studied in detail in certain microorganisms.

Corrinoids (such as the cobalamines and particularly vitamin B 12 and porphyrines belong to a group of chemicals characterized by a tetrapyrole ring system.

The biosynthesis of vitamin BI2 is sufficiently complex that it has not yet been completely characterized, but many of the enzymes and substrates involved are now known. Nicotinic acid (nicotinate), and nicotinamide are pyridine derivatives which are also termed 'niacin'. Niacin is the precursor of the important coenzymes NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate) and their reduced forms.

-16- The large-scale production of these compounds has largely relied on cell-free chemical syntheses, though some of these chemicals have also been produced by largescale culture of microorganisms, such as riboflavin, Vitamin B 6 pantothenate, and biotin. Only Vitamin B 1 2 is produced solely by fermentation, due to the complexity of its synthesis. In vitro methodologies require significant inputs of materials and time, often at great cost.

C. Purine, Pyrimidine, Nucleoside and Nucleotide Metabolism and Uses Purine and pyrimidine metabolism genes and their corresponding proteins are important targets for the therapy of tumor diseases and viral infections. The language "purine" or "pyrimidine" includes the nitrogenous bases which are constituents of nucleic acids, co-enzymes, and nucleotides. The term "nucleotide" includes the basic structural units of nucleic acid molecules, which are comprised of a nitrogenous base, a pentose sugar (in the case of RNA, the sugar is ribose; in the case of DNA, the sugar is D-deoxyribose), and phosphoric acid. The language "nucleoside" includes molecules which serve as precursors to nucleotides, but which are lacking the phosphoric acid moiety that nucleotides possess. By inhibiting the biosynthesis of these molecules, or their mobilization to form nucleic acid molecules, it is possible to inhibit RNA and DNA synthesis; by inhibiting this activity in a fashion targeted to cancerous cells, the ability of tumor cells to divide and replicate may be inhibited. Additionally, there are nucleotides which do not form nucleic acid molecules, but rather serve as energy stores AMP) or as coenzymes FAD and NAD).

Several publications have described the use of these chemicals for these medical indications, by influencing purine and/or pyrimidine metabolism Christopherson, R.I. and Lyons, S.D. (1990) "Potent inhibitors of de novo pyrimidine and purine biosynthesis as chemotherapeutic agents." Med. Res. Reviews 10: 505-548). Studies of enzymes involved in purine and pyrimidine metabolism have been focused on the development of new drugs which can be used, for example, as immunosuppressants or anti-proliferants (Smith, (1995) "Enzymes in nucleotide synthesis." Curr. Opin.

Struct. Biol. 5: 752-757; (1995) Biochem Soc. Transact. 23: 877-902). However, purine and pyrimidine bases, nucleosides and nucleotides have other utilities: as intermediates in the biosynthesis of several fine chemicals thiamine, S-adenosyl-methionine, -17folates, or riboflavin), as energy carriers for the cell ATP or GTP), and for chemicals themselves, commonly used as flavor enhancers IMP or GMP) or for several medicinal applications (see, for example, Kuninaka, A. (1996) Nucleotides and Related Compounds in Biotechnology vol. 6, Rehm et al., eds. VCH: Weinheim, p. 561- 612). Also, enzymes involved in purine, pyrimidine, nucleoside, or nucleotide metabolism are increasingly serving as targets against which chemicals for crop protection, including fungicides, herbicides and insecticides, are developed.

The metabolism of these compounds in bacteria has been characterized (for reviews see, for example, Zalkin, H. and Dixon, J.E. (1992) "de novo purine nucleotide biosynthesis", in: Progress in Nucleic Acid Research and Molecular Biology, vol. 42, Academic Press:, p. 259-287; and Michal, G. (1999) "Nucleotides and Nucleosides", Chapter 8 in: Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, Wiley: New York). Purine metabolism has been the subject of intensive research, and is essential to the normal functioning of the cell. Impaired purine metabolism in higher animals can cause severe disease, such as gout. Purine nucleotides are synthesized from in a series of steps through the intermediate compound phosphate (IMP), resulting in the production of guanosine-5'-monophosphate (GMP) or (AMP), from which the triphosphate forms utilized as nucleotides are readily formed. These compounds are also utilized as energy stores, so their degradation provides energy for many different biochemical processes in the cell.

Pyrimidine biosynthesis proceeds by the formation of uridine-5'-monophosphate (UMP) from ribose-5-phosphate. UMP, in turn, is converted to cytidine-5'-triphosphate (CTP).

The deoxy- forms of all of these nucleotides are produced in a one step reduction reaction from the diphosphate ribose form of the nucleotide to the diphosphate deoxyribose form of the nucleotide. Upon phosphorylation, these molecules are able to participate in DNA synthesis.

D. Trehalose Metabolism and Uses Trehalose consists of two glucose molecules, bound in a, a-1,1 linkage. It is commonly used in the food industry as a sweetener, an additive for dried or frozen foods, and in beverages. However, it also has applications in the pharmaceutical, cosmetics and biotechnology industries (see, for example, Nishimoto et al., (1998) U.S.

-18- Patent No. 5,759,610; Singer, M.A. and Lindquist, S. (1998) Trends Biotech. 16: 460- 467; Paiva, C.L.A. and Panek, A.D. (1996) Biotech. Ann. Rev. 2: 293-314; and Shiosaka, M. (1997) J. Japan 172: 97-102). Trehalose is produced by enzymes from many microorganisms and is naturally released into the surrounding medium, from which it can be collected using methods known in the art.

II. Membrane Biosynthesis and Transmembrane Transport Cellular membranes serve a variety of functions in a cell. First and foremost, a membrane differentiates the contents of a cell from the surrounding environment, thus giving integrity to the cell. Membranes may also serve as barriers to the influx of hazardous or unwanted compounds, and also to the efflux of desired compounds.

Cellular membranes are by nature impervious to the unfacilitated diffusion of hydrophilic compounds such as proteins, water molecules and ions due to their structure: a bilayer of lipid molecules in which the polar head groups face outwards (towards the exterior and interior of the cell, respectively) and the nonpolar tails face inwards at the center of the bilayer, forming a hydrophobic core (for a general review of membrane structure and function, see Gennis, R.B. (1989) Biomembranes, Molecular Structure and Function, Springer: Heidelberg). This barrier enables cells to maintain a relatively higher concentration of desired compounds and a relatively lower concentration of undesired compounds than are contained within the surrounding medium, since the diffusion of these compounds is effectively blocked by the membrane.

However, the membrane also presents an effective barrier to the import of desired compounds and the export of waste molecules. To overcome this difficulty, cellular membranes incorporate many kinds of transporter proteins which are able to facilitate the transmembrane transport of different kinds of compounds. There are two general classes of these transport proteins: pores or channels and transporters. The former are integral membrane proteins, sometimes complexes of proteins, which form a regulated hole through the membrane. This regulation, or 'gating' is generally specific to the molecules to be transported by the pore or channel, rendering these transmembrane constructs selectively permeable to a specific class of substrates; for example, a potassium channel is constructed such that only ions having a like charge and size to that of potassium may pass through. Channel and pore proteins tend to have discrete -19hydrophobic and hydrophilic domains, such that the hydrophobic face of the protein may associate with the interior of the membrane while the hydrophilic face lines the interior of the channel, thus providing a sheltered hydrophilic environment through which the selected hydrophilic molecule may pass. Many such pores/channels are known in the art, including those for potassium, calcium, sodium, and chloride ions.

This pore and channel-mediated system of facilitated diffusion is limited to very small molecules, such as ions, because pores or channels large enough to permit the passage of whole proteins by facilitated diffusion would be unable to prevent the passage of smaller hydrophilic molecules as well. Transport of molecules by this process is sometimes termed 'facilitated diffusion' since the driving force of a concentration gradient is required for the transport to occur. Permeases also permit facilitated diffusion of larger molecules, such as glucose or other sugars, into the cell when the concentration of these molecules on one side of the membrane is greater than that on the other (also called 'uniport'). In contrast to pores or channels, these integral membrane proteins (often having between 6-14 membrane-spanning a-helices) do not form open channels through the membrane, but rather bind to the target molecule at the surface of the membrane and then undergo a conformational shift such that the target molecule is released on the opposite side of the membrane.

However, cells frequently require the import or export of molecules against the existing concentration gradient ('active transport'), a situation in which facilitated diffusion cannot occur. There are two general mechanisms used by cells for such membrane transport: symport or antiport, and energy-coupled transport such as that mediated by the ABC transporters. Symport and antiport systems couple the movement of two different molecules across the membrane (via permeases having two separate binding sites for the two differerit molecules); in symport, both molecules are transported in the same direction, while in antiport, one molecule is imported while the other is exported. This is, possible energetically because one of the two molecules moves in accordance with a concentration gradient, and this energetically favorable event is permitted only upon concomitant movement of a desired compound against the prevailing concentration gradient. Single molecules may be transported across the membrane against the concentration gradient in an energy-driven process, such as that utilized by the ABC transporters. In this system, the transport protein located in the membrane has an ATP-binding cassette; upon binding of the target molecule, the ATP is converted to ADP Pi, and the resulting release of energy is used to drive the movement of the target molecule to the opposite face of the membrane, facilitated by the transporter. For more detailed descriptions of all of these transport systems, see: Bamberg, E. et al., (1993) "Charge transport of ion pumps on lipid bilayer membranes", Q. Rev. Biophys. 26: 1-25; Findlay, J.B.C. (1991) "Structure and function in membrane transport systems", Curr. Opin. Struct. Biol. 1:804-810; Higgins, C.F. (1992) "ABC transporters from microorganisms to man", Ann. Rev. Cell Biol. 8: 67-113; Gennis, R.B.

(1989) "Pores, Channels and Transporters", in: Biomembranes, Molecular Structure and Function, Springer: Heidelberg, p. 270-322; and Nikaido, H. and Saier, H. (1992) "Transport proteins in bacteria: common themes in their design", Science 258: 936-942, and references contained within each of these references.

The synthesis of membranes is a well-characterized process involving a number of components, the most important of which are lipid molecules. Lipid synthesis may be divided into two parts: the synthesis of fatty acids and their attachment to snglycerol-3-phosphate, and the addition or modification of a polar head group. Typical lipids utilized in bacterial membranes include phospholipids, glycolipids, sphingolipids, and phosphoglycerides. Fatty acid synthesis begins with the conversion of acetyl CoA either to malonyl CoA by acetyl CoA carboxylase, or to acetyl-ACP by acetyltransacylase. Following a condensation reaction, these two product molecules together form acetoacetyl-ACP, which is converted by a series of condensation, reduction and dehydration reactions to yield a saturated fatty acid molecule having a desired chain length. The production of unsaturated fatty acids from such molecules is catalyzed by specific desaturases either aerobically, with the help of molecular oxygen, or anaerobically (for reference on fatty acid synthesis, see F.C. Neidhardt et al. (1996) E. coli and Salmonella. ASM Press: Washington, p. 612-636 and references contained therein; Lengeler et al. (eds) (1999) Biology ofProcaryotes. Thieme: Stuttgart, New York, and references contained therein; and Magnuson, K. et al., (1993) Microbiological Reviews 57: 522-542, and references contained therein). The cyclopropane fatty acids (CFA) are synthesized by a specific CFA-synthase using SAM as a cosubstrate. Branched chain fatty acids are synthesized from branched chain amino acids that are deaminated to yield branched chain 2-oxo-acids (see Lengeler et al., eds.

-21- (1999) Biology of Procaryotes. Thieme: Stuttgart, New York, and references contained therein). Another essential step in lipid synthesis is the transfer of fatty acids onto the polar head groups by, for example, glycerol-phosphate-acyltransferases. The combination of various precursor molecules and biosynthetic enzymes results in the production of different fatty acid molecules, which has a profound effect on the composition of the membrane.

III. Elements and Methods of the Invention The present invention is based, at least in part, on the discovery of novel molecules, referred to herein as MCT nucleic acid and protein molecules, which control the production of cellular membranes in C. glutamicum and govern the movement of molecules across such membranes. In one embodiment, the MCT molecules participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. In a preferred embodiment, the activity of the MCT molecules of the present invention to regulate membrane component production and membrane transport has an impact on the production of a desired fine chemical by this organism. In a particularly preferred embodiment, the MCT molecules of the invention are modulated in activity, such that the C. glutamicum metabolic pathways which the MCT proteins of the invention regulate are modulated in yield, production, and/or efficiency of production and the transport of compounds through the membranes is altered in efficiency, which either directly or indirectly modulates the yield, production, and/or efficiency of production of a desired fine chemical by C. glutamicum.

The language, "MCT protein" or "MCT polypeptide" includes proteins which participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes.

Examples of MCT proteins include those encoded by the MCT genes set forth in Table 1 and by the odd-numbered SEQ ID NOs. The terms "MCT gene" or "MCT nucleic acid sequence" include nucleic acid sequences encoding an MCT protein, which consist of a coding region and also corresponding untranslated 5' and 3' sequence regions.

Examples of MCT genes include those set forth in Table 1. The terms "production" or "productivity" are art-recognized and include the concentration of the fermentation -22product (for example, the desired fine chemical) formed within a given time and a given fermentation volume kg product per hour per liter). The term "efficiency of production" includes the time required for a particular level of production to be achieved (for example, how long it takes for the cell to attain a particular rate of output of a fine chemical). The term "yield" or "product/carbon yield" is art-recognized and includes the efficiency of the conversion of the carbon source into the product fine chemical). This is generally written as, for example, kg product per kg carbon source.

By increasing the yield or production of the compound, the quantity of recovered molecules, or of useful recovered molecules of that compound in a given amount of culture over a given amount of time is increased. The terms "biosynthesis" or a "biosynthetic pathway" are art-recognized and include.the synthesis of a compound, preferably an organic compound, by a cell from intermediate compounds in what may be a multistep and highly regulated process. The terms "degradation" or a "degradation pathway" are art-recognized and include the breakdown of a compound, preferably an organic compound, by a cell to degradation products (generally speaking, smaller or less complex molecules) in what may be a multistep and highly regulated process. The language "metabolism" is art-recognized and includes the totality of the biochemical reactions that take place in an organism. The metabolism of a particular compound, then, the metabolism of an amino acid such as glycine) comprises the overall biosynthetic, modification, and degradation pathways in the cell related to this compound.

In another embodiment, the MCT molecules of the invention are capable of modulating the production of a desired molecule, such as a fine chemical, in a microorganism such as C. glutamicum. There are a number of mechanisms by which the alteration of an MCT protein of the invention may directly affect the yield, production, and/or efficiency of production of a fine chemical from a C. glutamicum strain incorporating such an altered protein. Those MCT proteins involved in the export of fine chemical molecules from the cell may be increased in number or activity such that greater quantities of these compounds are secreted to the extracellular medium, from which they are more readily recovered. Similarly, those MCT proteins involved in the import of nutrients necessary for the biosynthesis of one or more fine chemicals phosphate, sulfate, nitrogen compounds, etc.) may be increased in number or -23activity such that these precursor, cofactor, or intermediate compounds are increased in concentration within the cell. Further, fatty acids and lipids themselves are desirable fine chemicals; by optimizing the activity or increasing the number of one or more MCT proteins of the invention which participate in the biosynthesis of these compounds, or by impairing the activity of one or more MCT proteins which are involved in the degradation of these compounds, it may be possible to increase the yield, production, and/or efficiency of production of fatty acid and lipid molecules from C. glutamicum.

The mutagenesis of one or more MCT genes of the invention may also result in MCT proteins having altered activities which indirectly impact the production of one or more desired fine chemicals from C .glutamicum. For example, MCT proteins of the invention involved in the export of waste products may be increased in number or activity such that the normal metabolic wastes of the cell (possibly increased in quantity due to the overproduction of the desired fine chemical) are efficiently exported before they are able to damage nucleotides and proteins within the cell (which would decrease the viability of the cell) or to interfere with fine chemical biosynthetic pathways (which would decrease the yield, production, or efficiency of production of the desired fine chemical). Further, the relatively large intracellular quantities of the desired fine chemical may in itself be toxic to the cell, so by increasing the activity or number of transporters able to export this compound from the cell, one may increase the viability of the cell in culture, in turn leading to a greater number of cells in the culture producing the desired fine chemical. The MCT proteins of the invention may also be manipulated such that the relative amounts of different lipid and fatty acid molecules are produced.

This may have a profound effect on the lipid composition of the membrane of the cell.

Since each type of lipid has different physical properties, an alteration in the lipid composition of a membrane may significantly alter membrane fluidity. Changes in membrane fluidity can impact the transport of molecules across the membrane, as well as the integrity of the cell, both of which have a profound effect on the production of fine chemicals from C. glutamicum in large-scale fermentative culture.

The isolated nucleic acid sequences of the invention are contained within the genome of a Corynebacterium glutamicum strain available through the American Type Culture Collection, given designation ATCC 13032. The nucleotide sequence of the isolated C. glutamicum MCT DNAs and the predicted amino acid sequences of the C.

-24glutamicum MCT proteins are shown in the Sequence Listing as odd-numbered SEQ ID NOs and even-numbered SEQ ID NOs, respectively. Computational analyses were performed which classified and/or identified these nucleotide sequences as sequences which encode proteins involved in the metabolism of cellular membrane components or proteins involved in the transport of compounds across such membranes.

The present invention also pertains to proteins which have an amino acid sequence which is substantially homologous to an amino acid sequence of the invention the sequence of an even-numbered SEQ ID NO of the Sequence Listing).. As used herein, a protein which has an amino acid sequence which is substantially homologous to a selected amino acid sequence is least about 50% homologous to the selected amino acid sequence, the entire selected amino acid sequence. A protein which has an amino acid sequence which is substantially homologous to a selected amino acid sequence can also be least about 50-60%, preferably at least about 60-70%, and more preferably at least about 70-80%, 80-90%, or 90-95%, and most preferably at least about 96%, 97%, 98%, 99% or more homologous to the selected amino acid sequence.

The MCT protein or a biologically active portion or fragment thereof of the invention can participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or have one or more of the activities set forth in Table 1.

Various aspects of the invention are described in further detail in the following subsections: A. Isolated Nucleic Acid Molecules One aspect of the invention pertains to isolated nucleic acid molecules that encode MCT polypeptides or biologically active portions thereof, as well as nucleic acid fragments sufficient for use as hybridization probes or primers for the identification or amplification of MCT-encoding nucleic acid MCT DNA). As used herein, the term "nucleic acid molecule" is intended to include DNA molecules cDNA or genomic DNA) and RNA molecules mRNA) and analogs of the DNA or RNA generated using nucleotide analogs. This term also encompasses untranslated sequence located at both the 3' and 5' ends of the coding region of the gene: at least about 100 nucleotides of sequence upstream from the 5' end of the coding region and at least about nucleotides of sequence downstream from the 3'end of the coding region of the gene.

The nucleic acid molecule can be single-stranded or double-stranded, but preferably is double-stranded DNA. An "isolated" nucleic acid molecule is one which is separated from other nucleic acid molecules which are present in the natural source of the nucleic acid. Preferably, an "isolated" nucleic acid is free of sequences which naturally flank the nucleic acid sequences located at the 5' and 3' ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. For example, in various embodiments, the isolated MCT nucleic acid molecule can contain less than about 5 kb, 4kb, 3kb, 2kb, 1 kb, 0.5 kb or 0.1 kb ofnucleotide sequences which naturally flank the nucleic acid molecule in genomic DNA of the cell from which the nucleic acid is derived a C. glutamicum cell). Moreover, an "isolated" nucleic acid molecule, such as a DNA molecule, can be substantially free of other cellular material, or culture medium when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized.

A nucleic acid molecule of the present invention, a nucleic acid molecule having a nucleotide sequence of an odd-numbered SEQ ID NO of the Sequence Listing, or a portion thereof, can be isolated using standard molecular biology techniques and the sequence information provided herein. For example, a C. glutamicum MCT DNA can be isolated from a C. glutamicum library using all or portion of one of the odd-numbered SEQ ID NO sequences of the Sequence Listing as a hybridization probe and standard hybridization techniques as described in Sambrook, Fritsh, E. and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989).

Moreover, a nucleic acid molecule encompassing all or a portion of one of the nucleic acid sequences of the invention an odd-numbered SEQ ID NO:) can be isolated by the polymerase chain reaction using oligonucleotide primers designed based upon this sequence a nucleic acid molecule encompassing all or a portion of one of the nucleic acid sequences of the invention an odd-numbered SEQ ID NO of the Sequence Listing) can be isolated by the polymerase chain reaction using oligonucleotide primers designed based upon this same sequence). For example, mRNA can be isolated from normal endothelial cells by the guanidinium-thiocyanate extraction procedure of Chirgwin et al (1979) Biochemistry 18: 5294-5299) and DNA -26can be prepared using reverse transcriptase Moloney MLV reverse transcriptase, available from Gibco/BRL, Bethesda, MD; or AMV reverse transcriptase, available from Seikagaku America, Inc., St. Petersburg, FL). Synthetic oligonucleotide primers for polymerase chain reaction amplification can be designed based upon one of the nucleotide sequences shown in the Sequence Listing. A nucleic acid of the invention can be amplified using cDNA or, alternatively, genomic DNA, as a template and appropriate oligonucleotide primers according to standard PCR amplification techniques. The nucleic acid so amplified can be cloned into an appropriate vector and characterized by DNA sequence analysis. Furthermore, oligonucleotides corresponding to an MCT nucleotide sequence can be prepared by standard synthetic techniques, e.g., using an automated DNA synthesizer.

In a preferred embodiment, an isolated nucleic acid molecule of the invention comprises one of the nucleotide sequences shown in the Sequence Listing. The nucleic acid sequences of the invention, as set forth in the Sequence Listing correspond to the Corynebacterium glutamicum MCT DNAs of the invention. This DNA comprises sequences encoding MCT proteins the "coding region", indicated in each oddnumbered SEQ ID NO: in the Sequence Listing), as well as 5' untranslated sequences and 3' untranslated sequences, also indicated in each odd-numbered SEQ ID NO: in the Sequence Listing. Alternatively, the nucleic acid molecule can comprise only the coding region of any of the nucleic acid sequences of the Sequence Listing.

For the purposes of this application, it will be understood that each of the nucleic acid and amino acid sequences set forth in the Sequence Listing has an identifying RXA, RXN, RXS, or RXC number having the designation "RXA", "RXN", "RXS" or "RXC" followed by 5 digits RXA02099, RXN03097, RXS00148, or RXC01748). Each of the nucleic acid sequences comprises up to three parts: a 5' upstream region, a coding region, and a downstream region. Each of these three regions is identified by the same RXA, RXN, RXS, or RXC designation to eliminate confusion. The recitation "one of the odd-numbered sequences in of the Sequence Listing", then, refers to any of the nucleic acid sequences in the Sequence Listing, which may also be distinguished by their differing RXA, RXN, RXS, or RXC designations. The coding region of each of these sequences is translated into a corresponding amino acid sequence, which is also set forth in the Sequence Listing, as an even-numbered SEQ ID NO: immediately following 27 the corresponding nucleic acid sequence. For example, the coding region for RXA03097 is set forth in SEQ ID NO: 1, while the amino acid sequence which it encodes is set forth as SEQ ID NO:2. The sequences of the nucleic acid molecules of the invention are identified by the same RXA, RXN, RXS, or RXC designations as the amino acid molecules which they encode, such that they can be readily correlated. For example, the amino acid sequences designated RXA02099, RXN03097, RXS00148, and RXC01748 are translations of the coding region of the nucleotide sequences of nucleic acid molecules RXA02099, RXN03097, RXS00148, and RXC01748, respectively. The correspondence between the RXA, RXN, RXS, and RXC nucleotide and amino acid sequences of the invention and their assigned SEQ ID NOs is set forth in Table 1. For example, as set forth in Table 1, the nucleotide sequence of RXAOO 104 is SEQ ID and the amino acid sequence of RXA00104 is SEQ ID NO:6.

Several of the genes of the invention are "F-designated genes". An F-designated gene includes those genes set forth in Table 1 which have an in front of the RXA, RXN, RXS, or RXC designation. For example, SEQ ID NO: 11, designated, as indicated on Table 1, as "F RXA02581", is an F-designated gene, as are SEQ ID NOs: 31, 33, and 43 (designated on Table 1 as "F RXA02487", "F RXA02490", and "F RXA02809", respectively).

In one embodiment, the nucleic acid molecules of the present invention are not intended to include those compiled in Table 2. In the case of the dapD gene, a sequence for this gene was published in Wehrmann, et al. (1998) J. Bacteriol. 180(12): 3159- 3165. However, the sequence obtained by the inventors of the present application is significantly longer than the published version. It is believed that the published version relied on an incorrect start codon, and thus represents only a fragment of the actual coding region.

In another preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleic acid molecule which is a complement of one of the nucleotide sequences of the invention a sequence of an odd-numbered SEQ ID NO: of the Sequence Listing), or a portion thereof. A nucleic acid molecule which is complementary to one of the nucleotide sequences shown in of the invention is one which is sufficiently complementary to one of the nucleotide sequences shown in the Sequence Listing the sequence of an odd-numbered SEQ ID NO:)such that it can

~II-

-28hybridize to one of the nucleotide sequences of the invention, thereby forming a stable duplex.

In still another preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleotide sequence which is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or more preferably at least about 71%, 72%, 73%, 74%, 75%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to a nucleotide sequence of the invention a sequence of an odd-numbered SEQ ID NO: of the Sequence Listing), or a portion thereof. Ranges and identity values intermediate to the above-recited ranges, 70-90% identical or 80-95% identical) are also intended to be encompassed by the present invention. For example, ranges of identity values using a combination of any of the above values recited as upper and/or lower limits are intended to be included. In an additional preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleotide sequence which hybridizes, e.g., hybridizes under stringent conditions, to one of the nucleotide sequences of the invention, or a portion thereof.

Moreover, the nucleic acid molecule of the invention can comprise only a portion of the coding region of the sequence of one of the odd-numbered SEQ ID NOs of the Sequence Listing, for example a fragment which can be used as a probe or primer or a fragment encoding a biologically active portion of an MCT protein. The nucleotide sequences determined from the cloning of the MCT genes from C. glutamicum allows for the generation of probes and primers designed for use in identifying and/or cloning MCT homologues in other cell types and organisms, as well as MCT homologues from other Corynebacteria or related species. The probe/primer typically comprises substantially purified oligonucleotide. The oligonucleotide typically comprises a region of nucleotide sequence that hybridizes under stringent conditions to at least about 12, preferably about 25, more preferably about 40, 50 or 75 consecutive nucleotides of a sense strand of one of the nucleotide sequences of the invention a sequence of one of the odd-numbered SEQ ID NOs of the Sequence Listing), an anti-sense sequence of one of these sequences, or naturally occurring mutants thereof. Primers based on a -29nucleotide sequence of the invention can be used in PCR reactions to clone MCT homologues. Probes based on the MCT nucleotide sequences can be used to detect transcripts or genomic sequences encoding the same or homologous proteins. In preferred embodiments, the probe further comprises a label group attached thereto, e.g.

the label group can be a radioisotope, a fluorescent compound, an enzyme, or an enzyme co-factor. Such probes can be used as a part of a diagnostic test kit for identifying cells which misexpress an MCT protein, such as by measuring a level of an MCT-encoding nucleic acid in a sample of cells, detecting MCT mRNA levels or determining whether a genomic MCT gene has been mutated or deleted.

In one embodiment, the nucleic acid molecule of the invention encodes a protein or portion thereof which includes an amino acid sequence which is sufficiently homologous to an amino acid sequence of the invention a sequence of an evennumbered SEQ ID NO of the Sequence Listing) such that the protein or portion thereof maintains the ability to participate in the metabolism of compounds necessary for the construction of cellular membranes in C glutamicum, or in the transport of molecules across these membranes. As used herein, the language "sufficiently homologous" refers to proteins or portions thereof which have amino acid sequences which include a minimum number of identical or equivalent an amino acid residue which has a similar side chain as an amino acid residue in a sequence of one of the even-numbered SEQ ID NOs of the Sequence Listing) amino acid residues to an amino acid sequence of the invention such that the protein or portion thereof is able to participate in the metabolism of compounds necessary for the construction of cellular membranes in C.

glutamicum, or in the transport of molecules across these membranes. Protein members of such membrane component metabolic pathways or membrane transport systems, as described herein, may play a role in the production and secretion of one or more fine chemicals. Examples of such activities are also described herein. Thus, "the function of an MCT protein" contributes either directly or indirectly to the yield, production, and/or efficiency of production of one or more fine chemicals. Examples of MCT protein activities are set forth in Table I.

In another embodiment, the protein is at least about 50-60%, preferably at least about 60-70%, and more preferably at least about 70-80%, 80-90%, 90-95%, and most preferably at least about 96%, 97%, 98%, 99% or more homologous to an entire amino acid sequence of the invention a sequence of an even-numbered SEQ ID NO: of the Sequence Listing).

Portions of proteins encoded by the MCT nucleic acid molecules of the invention are preferably biologically active portions of one of the MCT proteins. As used herein, the term "biologically active portion of an MCT protein" is intended to include a portion, a domain/motif, of an MCT protein that participates in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or has an activity as set forth in Table 1. To determine whether an MCT protein or a biologically active portion thereof can participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, an assay of enzymatic activity may be performed. Such assay methods are well known to those of ordinary skill in the art, as detailed in Example 8 of the Exemplification.

Additional nucleic acid fragments encoding biologically active portions of an MCT protein can be prepared by isolating a portion of one of the amino acid sequences of the invention a sequence of an even-numbered SEQ ID NO: of the Sequence Listing), expressing the encoded portion of the MCT protein or peptide by recombinant expression in vitro) and assessing the activity of the encoded portion of the MCT protein or peptide.

The invention further encompasses nucleic acid molecules that differ from one of the nucleotide sequences shown of the invention a sequence of an odd-numbered SEQ ID NO: of the Sequence Listing) (and portions thereof) due to degeneracy of the genetic code and thus encode the same MCT protein as that encoded by the nucleotide sequences of the invention. In another embodiment, an isolated nucleic acid molecule of the invention has a nucleotide sequence encoding a protein having an amino acid sequence shown in the Sequence Listing an even-numbered SEQ ID In a still further embodiment, the nucleic acid molecule of the invention encodes a full length C. glutamicum protein which is substantially homologous to an amino acid sequence of the invention (encoded by an open reading frame shown in an odd-numbered SEQ ID NO: of the Sequence Listing).

-31 It will be understood by one of ordinary skill in the art that in one embodiment the sequences of the invention are not meant to include the sequences of the prior art, such as those Genbank sequences set forth in Tables 2 or 4 which were available prior to the present invention. In one embodiment, the invention includes nucleotide and amino acid sequences having a percent identity to a nucleotide or amino acid sequence of the invention which is greater than that of a sequence of the prior art a Genbank sequence (or the protein encoded by such a sequence) set forth in Tables 2 or For example, the invention includes a nucleotide sequence which is greater than and/or at least 38% identical to the nucleotide sequence designated RXA01420 (SEQ ID NO:7), a nucleotide sequence which is greater than and/or at least 43% identical to the nucleotide sequence designated RXA00104 (SEQ ID NO:5), and a nucleotide sequence which is greater than and/or at least 45% identical to the nucleotide sequence designated RXA02173 (SEQ ID NO:25). One of ordinary skill in the art would be able to calculate the lower threshold of percent identity for any given sequence of the invention by examining the GAP-calculated percent identity scores set forth in Table 4 for each of the three top hits for the given sequence, and by subtracting the highest GAP-calculated percent identity from 100 percent. One of ordinary skill in the art will also appreciate that nucleic acid and amino acid sequences having percent identities greater than the lower threshold so calculated at least 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more identical) are also encompassed by the invention.

In addition to the C glutamicum MCT nucleotide sequences set forth in the Sequence Listing as odd-numbered SEQ ID NOs, it will be appreciated by one of ordinary skill in the art that DNA sequence polymorphisms that lead to changes in the amino acid sequences of MCT proteins may exist within a population the C.

glutamicum population). Such genetic polymorphism in the MCT gene may exist among individuals within a population due to natural variation. As used herein, the terms "gene" and "recombinant gene" refer to nucleic acid molecules comprising an open reading frame encoding an MCT protein, preferably a C. glutamicum MCT protein.

-32- Such natural variations can typically result in 1-5% variance in the nucleotide sequence of the MCT gene. Any and all such nucleotide variations and resulting amino acid polymorphisms in MCT that are the result of natural variation and that do not alter the functional activity of MCT proteins are intended to be within the scope of the invention.

Nucleic acid molecules corresponding to natural variants and non-C. glutamicum homologues of the C. glutamicum MCT DNA of the invention can be isolated based on their homology to the C. glutamicum MCT nucleic acid disclosed herein using the C.

glutamicum DNA, or a portion thereof, as a hybridization probe according to standard hybridization techniques under stringent hybridization conditions. Accordingly, in another embodiment, an isolated nucleic acid molecule of the invention is at least nucleotides in length and hybridizes under stringent conditions to the nucleic acid molecule comprising a nucleotide sequence of an odd-numbered SEQ ID NO: of the Sequence Listing. In other embodiments, the nucleic acid is at least 30, 50, 100, 250 or more nucleotides in length. As used herein, the term "hybridizes under stringent conditions" is intended to describe conditions for hybridization and washing under which nucleotide sequences at least 60% homologous to each other typically remain hybridized to each other. Preferably, the conditions are such that sequences at least about 65%, more preferably at least about 70%, and even more preferably at least about or more homologous to each other typically remain hybridized to each other. Such stringent conditions are known to those of ordinary skill in the art and can be found in Current Protocols in Molecular Biology, John Wiley Sons, N.Y. (1989), 6.3.1-6.3.6.

A preferred, non-limiting example of stringent hybridization conditions are hybridization in 6X sodium chloride/sodium citrate (SSC) at about 451C, followed by one or more washes in 0.2 X SSC, 0.1% SDS at 50-65 0 C. Preferably, an isolated nucleic acid molecule of the invention that hybridizes under stringent conditions to a nucleotide sequence of the invention corresponds to a naturally-occurring nucleic acid molecule. As used herein, a "naturally-occurring" nucleic acid molecule refers to an RNA or DNA molecule having a nucleotide sequence that occurs in nature encodes a natural protein). In one embodiment, the nucleic acid encodes a natural C.

glutamicum MCT protein.

In addition to naturally-occurring variants of the MCT sequence that may exist in the population, one of ordinary skill in the art will further appreciate that changes can be -33introduced by mutation into a nucleotide sequence of the invention, thereby leading to changes in the amino acid sequence of the encoded MCT protein, without altering the functional ability of the MCT protein. For example, nucleotide substitutions leading to amino acid substitutions at "non-essential" amino acid residues can be made in a nucleotide sequence of the invention. A "non-essential" amino acid residue is a residue that can be altered from the wild-type sequence of one of the MCT proteins an even-numbered SEQ ID NO: of the Sequence Listing) without altering the activity of said MCT protein, whereas an "essential" amino acid residue is required for MCT protein activity. Other amino acid residues, however, those that are not conserved or only semi-conserved in the domain having MCT activity) may not be essential for activity and thus are likely to be amenable to alteration without altering MCT activity.

Accordingly, another aspect of the invention pertains to nucleic acid molecules encoding MCT proteins that contain changes in amino acid residues that are not essential for MCT activity. Such MCT proteins differ in amino acid sequence from a sequence of an even-numbered SEQ ID NO: of the Sequence Listing yet retain at least one of the MCT activities described herein. In one embodiment, the isolated nucleic acid molecule comprises a nucleotide sequence encoding a protein, wherein the protein comprises an amino acid sequence at least about 50% homologous to an amino acid sequence of the invention and is capable of participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or has one or more activities set forth in Table 1. Preferably, the protein encoded by the nucleic acid molecule is at least about 50-60% homologous to the amino acid sequence of one of the odd-numbered SEQ ID NOs of the Sequence Listing, more preferably at least about 60-70% homologous to one of these sequences, even more preferably at least about 70-80%, 80-90%, 90-95% homologous to one of these sequences, and most preferably at least about 96%, 97%, 98%, or 99% homologous to one of the amino acid sequences of the invention..

To determine the percent homology of two amino acid sequences one of the amino acid sequences of the invention and a mutant form thereof) or of two nucleic acids, the sequences are aligned for optimal comparison purposes gaps can be introduced in the sequence of one protein or nucleic acid for optimal alignment with the other protein or nucleic acid). The amino acid residues or nucleotides at corresponding -34amino acid positions or nucleotide positions are then compared. When a position in one sequence one of the amino acid sequences of the invention) is occupied by the same amino acid residue or nucleotide as the corresponding position in the other sequence a mutant form of the amino acid sequence), then the molecules are homologous at that position as used herein amino acid or nucleic acid "homology" is equivalent to amino acid or nucleic acid "identity"). The percent homology between the two sequences is a function of the number of identical positions shared by the sequences homology of identical positions/total of positions x 100).

An isolated nucleic acid molecule encoding an MCT protein homologous to a protein sequence of the invention a sequence of an even-numbered SEQ ID NO: of the Sequence Listing) can be created by introducing one or more nucleotide substitutions, additions or deletions into a nucleotide sequence of the invention such that one or more amino acid substitutions, additions or deletions are introduced into the encoded protein. Mutations can be introduced into one of the nucleotide sequences of the invention by standard techniques, such as site-directed mutagenesis and PCRmediated mutagenesis. Preferably, conservative amino acid substitutions are made at one or more predicted non-essential amino acid residues. A "conservative amino acid substitution" is one in which the amino acid residue is replaced with an amino acid residue having a similar side chain. Families of amino acid residues having similar side chains have been defined in the art. These families include amino acids with basic side chains lysine, arginine, histidine), acidic side chains aspartic acid, glutamic acid), uncharged polar side chains glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains threonine, valine, isoleucine) and aromatic side chains tyrosine, phenylalanine, tryptophan, histidine). Thus, a predicted nonessential amino acid residue in an MCT protein is preferably replaced with another amino acid residue from the same side chain family. Alternatively, in another embodiment, mutations can be introduced randomly along all or part of an MCT coding sequence, such as by saturation mutagenesis, and the resultant mutants can be screened for an MCT activity described herein to identify mutants that retain MCT activity. Following mutagenesis of the nucleotide sequence of one of the odd-numbered SEQ ID NOs of the Sequence Listing, the encoded protein can be expressed recombinantly and the activity of the protein can be determined using, for example, assays described herein (see Example 8 of the Exemplification).

In addition to the nucleic acid molecules encoding MCT proteins described above, another aspect of the invention pertains to isolated nucleic acid molecules which are antisense thereto. An "antisense" nucleic acid comprises a nucleotide sequence which is complementary to a "sense" nucleic acid encoding a protein, e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence. Accordingly, an antisense nucleic acid can hydrogen bond to a sense nucleic acid. The antisense nucleic acid can be complementary to an entire MCT coding strand, or to only a portion thereof. In one embodiment, an antisense nucleic acid molecule is antisense to a "coding region" of the coding strand of a nucleotide sequence encoding an MCT protein. The term "coding region" refers to the region of the nucleotide sequence comprising codons which are translated into amino acid residues the entire coding region of SEQ ID (RXA00104) comprises nucleotides 1 to 756). In another embodiment, the antisense nucleic acid molecule is antisense to a "noncoding region" of the coding strand of a nucleotide sequence encoding MCT. The term "noncoding region" refers to 5' and 3' sequences which flank the coding region that are not translated into amino acids also referred to as 5' and 3' untranslated regions).

Given the coding strand sequences encoding MCT disclosed herein the sequences set forth as odd-numbered SEQ ID NOs in the Sequence Listing), antisense nucleic acids of the invention can be designed according to the rules of Watson and Crick base pairing. The antisense nucleic acid molecule can be complementary to the entire coding region of MCT mRNA, but more preferably is an oligonucleotide which is antisense to only a portion of the coding or noncoding region of MCT mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of MCT mRNA. An antisense oligonucleotide can be, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length. An antisense nucleic acid of the invention can be constructed using chemical synthesis and enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid an antisense oligonucleotide) can be chemically synthesized -36using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, phosphorothioate derivatives and acridine substituted nucleotides can be used. Examples of modified nucleotides which can be used to generate the antisense nucleic acid include fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-Dgalactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyladenine, acid wybutoxosine, pseudouracil, queosine, 2-thiocytosine, methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5- oxyacetic acid methylester, uracil-5-oxyacetic acid 5-methyl-2-thiouracil, 3-(3-amino-3-N-2carboxypropyl) uracil, (acp3)w, and 2,6-diaminopurine. Alternatively, the antisense nucleic acid can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection).

The antisense nucleic acid molecules of the invention are typically administered to a cell or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding an MCT protein to thereby inhibit expression of the protein, by inhibiting transcription and/or translation. The hybridization can be by conventional nucleotide complementarity to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule which binds to DNA duplexes, through specific interactions in the major groove of the double helix. The antisense molecule can be modified such that it specifically binds to a receptor or an antigen expressed on a selected cell surface, by linking the antisense nucleic acid molecule to a peptide or an antibody which binds to a cell surface receptor or antigen. The antisense nucleic acid molecule can also be delivered to cells using the vectors described herein. To achieve -37sufficient intracellular concentrations of the antisense molecules, vector constructs in which the antisense nucleic acid molecule is placed under the control of a strong prokaryotic, viral, or eukaryotic promoter are preferred.

In yet another embodiment, the antisense nucleic acid molecule of the invention is an a-anomeric nucleic acid molecule. An a-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual p-units, the strands run parallel to each other (Gaultier et al. (1987) Nucleic Acids.

Res. 15:6625-6641). The antisense nucleic acid molecule can also comprise a 2'-omethylribonucleotide (Inoue et al. (1987) Nucleic Acids Res. 15:6131-6148) or a chimeric RNA-DNA analogue (Inoue et al. (1987) FEBS Lett. 215:327-330).

In still another embodiment, an antisense nucleic acid of the invention is a ribozyme. Ribozymes are catalytic RNA molecules with ribonuclease activity which are capable of cleaving a single-stranded nucleic acid, such as an mRNA, to which they have a complementary region. Thus, ribozymes hammerhead ribozymes (described in Haselhoff and Gerlach (1988) Nature 334:585-591)) can be used to catalytically cleave MCT mRNA transcripts to thereby inhibit translation of MCT mRNA. A ribozyme having specificity for an MCT-encoding nucleic acid can be designed based upon the nucleotide sequence of an MCT DNA disclosed herein SEQ ID NO. 5 (RXA00104). For example, a derivative of a Tetrahymena L-19 IVS RNA can be constructed in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in an MCT-encoding mRNA.

See, Cech et al. U.S. Patent No. 4,987,071 and Cech et al. U.S. Patent No.

5,116,742. Alternatively, MCT mRNA can be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules. See, Bartel, D. and Szostak, J.W. (1993) Science 261:1411-1418.

Alternatively, MCT gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of an MCT nucleotide sequence an MCT promoter and/or enhancers) to form triple helical structures that prevent transcription of an MCT gene in target cells. See generally, Helene, C. (1991) Anticancer Drug Des. 6(6):569-84; Helene, C. et al. (1992) Ann. N. Y. Acad. Sci. 660:27- 36; and Maher, L.J. (1992) Bioassays 14(12):807-15.

-38- B. Recombinant Expression Vectors and Host Cells Another aspect of the invention pertains to vectors, preferably expression vectors, containing a nucleic acid encoding an MCT protein (or a portion thereof). As used herein, the term "vector" refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. One type of vector is a "plasmid", which refers to a circular double stranded DNA loop into which additional DNA segments can be ligated. Another type of vector is a viral vector, wherein additional DNA segments can be ligated into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. Moreover, certain vectors are capable of directing the expression of genes to which they are operatively linked. Such vectors are referred to herein as "expression vectors". In general, expression vectors of utility in recombinant DNA techniques are often in the form ofplasmids. In the present specification, "plasmid" and "vector" can be used interchangeably as the plasmid is the most commonly used form of vector.

However, the invention is intended to include such other forms of expression vectors, such as viral vectors replication defective retroviruses, adenoviruses and adenoassociated viruses), which serve equivalent functions.

The recombinant expression vectors of the invention comprise a nucleic acid of the invention in a form suitable for.expression of the nucleic acid in a host cell, which means that the recombinant expression vectors include one or more regulatory sequences, selected on the basis of the host cells to be used for expression, which is operatively linked to the nucleic acid sequence to be expressed. Within a recombinant expression vector, "operably linked" is intended to mean that the nucleotide sequence of interest is linked to the regulatory sequence(s) in a manner which allows for expression of the nucleotide sequence in an in vitro transcription/translation system or in a host cell when the vector is introduced into the host cell). The term "regulatory sequence" is intended to include promoters, enhancers and other expression control elements polyadenylation signals). Such regulatory sequences are described, for example, in Goeddel; Gene Expression Technology: Methods in Enzymology 185, -39- Academic Press, San Diego, CA (1990). Regulatory sequences include those which direct constitutive expression of a nucleotide sequence in many types of host cell and those which direct expression of the nucleotide sequence only in certain host cells.

Preferred regulatory sequences are, for example, promoters such as cos-, tac-, trp-, tet-, trp-tet-, Ipp-, lac-, Ipp-lac-, lacI q T7-, T5-, T3-, gal-, trc-, ara-, SP6-, amy, SPO2, X-PRor PL, which are used preferably in bacteria. Additional regulatory sequences are, for example, promoters from yeasts and fungi, such as ADC1, MFa, AC, P-60, CYC1, GAPDH, TEF, rp28, ADH, promoters from plants such as CaMV/35S, SSU, OCS, lib4, usp, STLSI, B33, nos or ubiquitin- or phaseolin-promoters. It is also possible to use artificial promoters. It will be appreciated by one of ordinary skill in the art that the design of the expression vector can depend on such factors as the choice of the host cell to be transfdrmed, the level of expression of protein desired, etc. The expression vectors of the invention can be introduced into host cells to thereby produce proteins or peptides, including fusion proteins or peptides, encoded by nucleic acids as described herein MCT proteins, mutant forms of MCT proteins, fusion proteins, etc.).

The recombinant expression vectors of the invention can be designed for expression of MCT proteins in prokaryotic or eukaryotic cells. For example, MCT genes can be expressed in bacterial cells such as C. glutamicum, insect cells (using baculovirus expression vectors), yeast and other fungal cells (see Romanos, M.A. et al.

(1992) "Foreign gene expression in yeast: a review", Yeast 8: 423-488; van den Hondel, C.A.M.J.J. et al. (1991) "Heterologous gene expression in filamentous fungi" in: More Gene Manipulations in Fungi, J.W. Bennet L.L. Lasure, eds., p. 396-428: Academic Press: San Diego; and van den Hondel, C.A.M.J.J. Punt, P.J. (1991) "Gene transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, Peberdy, J.F. et al., eds., p. 1-28, Cambridge University Press: Cambridge), algae and multicellular plant cells (see Schmidt, R. and Willmitzer, L. (1988) High efficiency Agrobacterium tumefaciens -mediated transformation of Arabidopsis thaliana leaf and cotyledon explants" Plant Cell Rep.: 583-586), or mammalian cells.

Suitable host cells are discussed further in Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, CA (1990). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and T7 polymerase.

Expression of proteins in prokaryotes is most often carried out with vectors containing constitutive or inducible promoters directing the expression of either fusion or non-fusion proteins. Fusion vectors add a number of amino acids to a protein encoded therein, usually to the amino terminus of the recombinant protein but also to the C-terminus or fused within suitable regions in the proteins. Such fusion vectors typically serve three purposes: 1) to increase expression of recombinant protein; 2) to increase the solubility of the recombinant protein; and 3) to aid in the purification of the recombinant protein by acting as a ligand in affinity purification. Often, in fusion expression vectors, a proteolytic cleavage site is introduced at the junction of the fusion moiety and the recombinant protein to enable separation of the recombinant protein from the fusion moiety subsequent to purification of the fusion protein. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin and enterokinase.

Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc; Smith, D.B. and Johnson, K.S. (1988) Gene 67:31-40), pMAL (New England Biolabs, Beverly, MA) and pRIT5 (Pharmacia, Piscataway, NJ) which fuse glutathione S-transferase (GST), maltose E binding protein, or protein A, respectively, to the target recombinant protein. In one embodiment, the coding sequence of the MCT protein is cloned into a pGEX expression vector to create a vector encoding a fusion protein comprising, from the N-terminus to the C-terminus, GST-thrombin cleavage site-X protein. The fusion protein can be purified by affinity chromatography using glutathione-agarose resin.

Recombinant MCT protein unfused to GST can be recovered by cleavage of the fusion protein with thrombin.

Examples of suitable inducible non-fusion E. coli expression vectors include pTrc (Amann et al., (1988) Gene 69:301-315) pLG338, pACYC184, pBR322, pUCI 8, pUC19, pKC30, pRep4, pHS1, pHS2, pPLc236, pMBL24, pLG200, pUR290, pIN- III 113-B1, Xgtl 1, pBdCl, and pET 1 d (Studier et al., Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, California (1990) 60-89 and Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018).

Target gene expression from the pTrc vector relies on host RNA polymerase transcription from a hybrid trp-lac fusion promoter. Target gene expression from the pET lid vector relies on transcription from a T7 gnlO-lac fusion promoter mediated by a coexpressed viral RNA polymerase (T7 gnl). This viral polymerase is supplied by -41 host strains BL21(DE3) or HMS174(DE3) from a resident prophage harboring a T7 gnl gene under the transcriptional control of the lacUV 5 promoter. For transformation of other varieties of bacteria, appropriate vectors may be selected. For example, the plasmids pIJl01, pIJ364, pIJ702 and plJ361 are known to be useful in transforming Streptomyces, while plasmids pUB 110, pC194, or pBD214 are suited for transformation of Bacillus species. Several plasmids of use in the transfer of genetic information into Corynebacterium include pHM1519, pBL1, pSA77, or pAJ667 (Pouwels et al., eds.

(1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018).

One strategy to maximize recombinant protein expression is to express the protein in a host bacteria with an impaired capacity to proteolytically cleave the recombinant protein (Gottesman, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, California (1990) 119-128). Another strategy is to alter the nucleic acid sequence of the nucleic acid to be inserted into an expression vector so that the individual codons for each amino acid are those preferentially utilized in the bacterium chosen for expression, such as C. glutamicum (Wada et al. (1992) Nucleic Acids Res. 20:2111-2118). Such alteration of nucleic acid sequences of the invention can be carried out by standard DNA synthesis techniques.

In another embodiment, the MCT protein expression vector is a yeast expression vector. Examples of vectors for expression in yeast S. cerevisiae include pYepSecl (Baldari, et al., (1987) Embo J. 6:229-234), 2 u, pAG-1, Yep6, Yepl3, pEMBLYe23, pMFa (Kurjan and Herskowitz, (1982) Cell 30:933-943), pJRY88 (Schultz et al., (1987) Gene 54:113-123), and pYES2 (Invitrogen Corporation, San Diego, CA). Vectors and methods for the construction of vectors appropriate for use in other fungi, such as the filamentous fungi, include those detailed in: van den Hondel, C.A.M.J.J. Punt, P.J.

(1991) "Gene transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, J.F. Peberdy, et al., eds., p. 1-28, Cambridge University Press: Cambridge, and Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York (IBSN 0 444 904018).

Alternatively, the MCT proteins of the invention can be expressed in insect cells using baculovirus expression vectors. Baculovirus vectors available for expression of proteins in cultured insect cells Sf9 cells) include the pAc series (Smith et al.

-42- (1983) Mol. Cell Biol. 3:2156-2165) and the pVL series (Lucklow and Summers (1989) Virology 170:31-39).

In another embodiment, the MCT proteins of the invention may be expressed in unicellular plant cells (such as algae) or in plant cells from higher plants the spermatophytes, such as crop plants). Examples of plant expression vectors include those detailed in: Becker, Kemper, Schell, J. and Masterson, R. (1992) "New plant binary vectors with selectable markers located proximal to the left border", Plant Mol. Biol. 20: 1195-1197; and Bevan, M.W. (1984) "Binary Agrobacterium vectors for plant transformation", Nucl. Acid. Res. 12: 8711-8721, and include pLGV23, pGHlac+, pBIN 19, pAK2004, and pDH51 (Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018).

In yet another embodiment, a nucleic acid of the invention is expressed in mammalian cells using a mammalian expression vector. Examples of mammalian expression vectors include pCDM8 (Seed, B. (1987) Nature 329:840) and pMT2PC (Kaufman et al. (1987) EMBOJ. 6:187-195). When used in mammalian cells, the expression vector's control functions are often provided by viral regulatory elements.

For example, commonly used promoters are derived from polyoma, Adenovirus 2, cytomegalovirus and Simian Virus 40. For other suitable expression systems for both prokaryotic and eukaryotic cells see chapters 16 and 17 of Sambrook, Fritsh, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.

In another embodiment, the recombinant mammalian expression vector is capable of directing expression of the nucleic acid preferentially in a particular cell type tissue-specific regulatory elements are used to express the nucleic acid). Tissuespecific regulatory elements are known in the art. Non-limiting examples of suitable tissue-specific promoters include the albumin promoter (liver-specific; Pinkert et al.

(1987) Genes Dev. 1:268-277), lymphoid-specific promoters (Calame and Eaton (1988) Adv. Immunol. 43:235-275), in particular promoters of T cell receptors (Winoto and Baltimore (1989) EMBO J. 8:729-733) and immunoglobulins (Banerji et al. (1983) Cell 33:729-740; Queen and Baltimore (1983) Cell 33:741-748), neuron-specific promoters the neurofilament promoter; Byme and Ruddle (1989) PNAS 86:5473-5477), -43pancreas-specific promoters (Edlund et al. (1985) Science 230:912-916), and mammary gland-specific promoters milk whey promoter; U.S. Patent No. 4,873,316 and European Application Publication No. 264,166). Developmentally-regulated promoters are also encompassed, for example the murine hox promoters (Kessel and Gruss (1990) Science 249:374-379) and the ca-fetoprotein promoter (Campes and Tilghman (1989) Genes Dev. 3:537-546).

The invention further provides a recombinant expression vector comprising a DNA molecule of the invention cloned into the expression vector in an antisense orientation. That is, the DNA molecule is operatively linked to a regulatory sequence in a manner which allows for expression (by transcription of the DNA molecule) of an RNA molecule which is antisense to MCT mRNA. Regulatory sequences operatively linked to a nucleic acid cloned in the antisense orientation can be chosen which direct the continuous expression of the antisense RNA molecule in a variety of cell types, for instance viral promoters and/or enhancers, or regulatory sequences can be chosen which direct constitutive, tissue, specific or cell type specific expression of antisense RNA.

The antisense expression vector can be in the form of a recombinant plasmid, phagemid or attenuated virus in which antisense nucleic acids are produced under the control of a high efficiency regulatory region, the activity of which can be determined by the cell type into which the vector is introduced. For a discussion of the regulation of gene expression using antisense genes see Weintraub, H. et al., Antisense RNA as a molecular tool for genetic analysis, Reviews Trends in Genetics, Vol. 1(1) 1986.

Another aspect of the invention pertains to host cells into which a recombinant expression vector of the invention has been introduced. The terms "host cell" and "recombinant host cell" are used interchangeably herein. It is understood that such terms refer not only to the particular subject cell but to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein.

A host cell can be any prokaryotic or eukaryotic cell. For example, an MCT protein can be expressed in bacterial cells such as C. glutamicum, insect cells, yeast or mammalian cells (such as Chinese hamster ovary cells (CHO) or COS cells). Other -44suitable host cells are known to one of ordinary skill in the art. Microorganisms related to Corynebacterium glutamicum which may be conveniently used as host cells for the nucleic acid and protein molecules of the invention are set forth in Table 3.

Vector DNA can be introduced into prokaryotic or eukaryotic cells via conventional transformation or transfection techniques. As used herein, the terms "transformation" and "transfection", "conjugation" and "transduction" are intended to refer to a variety of art-recognized techniques for introducing foreign nucleic acid linear DNA or RNA a linearized vector or a gene construct alone without a vector) or nucleic acid in the form of a vector a plasmid, phage, phasmid, phagemid, transposon or other DNA) into a host cell, including calcium phosphate or calcium chloride co-precipitation, DEAE-dextran-mediated transfection, lipofection, natural competence, chemical-mediated transfer, or electroporation. Suitable methods for transforming or transfecting host cells can be found in Sambrook, et al. (Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989), and other laboratory manuals.

For stable transfection of mammalian cells, it is known that, depending upon the expression vector and transfection technique used, only a small fraction of cells may integrate the foreign DNA into their genome. In order to identify and select these integrants, a gene that encodes a selectable marker resistance to antibiotics) is generally introduced into the host cells along with the gene of interest. Preferred selectable markers include those which confer resistance to drugs, such as G418, hygromycin and methotrexate. Nucleic acid encoding a selectable marker can be introduced into a host cell on the same vector as that encoding an MCT protein or can be introduced on a separate vector. Cells stably transfected with the introduced nucleic acid can be identified by, for example, drug selection cells that have incorporated the selectable marker gene will survive, while the other cells die).

To create a homologous recombinant microorganism, a vector is prepared which contains at least a portion of an MCT gene into which a deletion, addition or substitution has been introduced to thereby alter, functionally disrupt, the MCT gene.

Preferably, this MCT gene is a Corynebacterium glutamicum MCT gene, but it can be a homologue from a related bacterium or even from a mammalian, yeast, or insect source.

In a preferred embodiment, the vector is designed such that, upon homologous recombination, the endogenous MCT gene is functionally disrupted no longer encodes a functional protein; also referred to as a "knock out" vector). Alternatively, the vector can be designed such that, upon homologous recombination, the endogenous MCT gene is mutated or otherwise altered but still encodes functional protein the upstream regulatory region can be altered to thereby alter the expression of the endogenous MCT protein). In the homologous recombination vector, the altered portion of the MCT gene is flanked at its 5' and 3' ends by additional nucleic acid of the MCT gene to allow for homologous recombination to occur between the exogenous MCT gene carried by the vector and an endogenous MCT gene in a microorganism. The additional flanking MCT nucleic acid is of sufficient length for successful homologous recombination with the endogenous gene. Typically, several kilobases of flanking DNA (both at the 5' and 3' ends) are included in the vector (see Thomas, and Capecchi, M.R. (1987) Cell 51: 503 for a description of homologous recombination vectors). The vector is introduced into a microorganism by electroporation) and cells in which the introduced MCT gene has homologously recombined with the endogenous MCT gene are selected, using art-known techniques.

In another embodiment, recombinant microorganisms can be produced which contain selected systems which allow for regulated expression of the introduced gene.

For example, inclusion of an MCT gene on a vector placing it under control of the lac operon permits expression of the MCT gene only in the presence of IPTG. Such regulatory systems are well known in the art.

In another embodiment, an endogenous MCT gene in a host cell is disrupted by homologous recombination or other genetic means known in the art) such that expression of its protein product does not occur. In another embodiment, an endogenous or introduced MCT gene in a host cell has been altered by one or more point mutations, deletions, or inversions, but still encodes a functional MCT protein. In still another embodiment, one or more of the regulatory regions a promoter, repressor, or inducer) of an MCT gene in a microorganism has been altered by deletion, truncation, inversion, or point mutation) such that the expression of the MCT gene is modulated. One of ordinary skill in the art will appreciate that host cells containing more than one of the described MCT gene and protein modifications may be readily -46produced using the methods of the invention, and are meant to be included in the present invention.

A host cell of the invention, such as a prokaryotic or eukaryotic host cell in culture, can be used to produce express) an MCT protein. Accordingly, the invention further provides methods for producing MCT proteins using the host cells of the invention. In one embodiment, the method comprises culturing the host cell of invention (into which a recombinant expression vector encoding an MCT protein has been introduced, or into which genome has been introduced a gene encoding a wild-type or altered MCT protein) in a suitable medium until MCT protein is produced. In another embodiment, the method further comprises isolating MCT proteins from the medium or the host cell.

C. Isolated MCT Proteins Another aspect of the invention pertains to isolated MCT proteins, and biologically active portions thereof. An "isolated" or "purified" protein or biologically active portion thereof is substantially free of cellular material when produced by recombinant DNA techniques, or chemical precursors or other chemicals when chemically synthesized. The language "substantially free of cellular material" includes preparations of MCTprotein in which the protein is separated from cellular components of the cells in which it is naturally or recombinantly produced. In one embodiment, the language "substantially free of cellular material" includes preparations of MCT protein having less than about 30% (by dry weight) of non-MCT protein (also referred to herein as a "contaminating protein"), more preferably less than about 20% of non-MCT protein, still more preferably less than about 10% of non-MCT protein, and most preferably less than about 5% non-MCT protein. When the MCT protein or biologically active portion thereof is recombinantly produced, it is also preferably substantially free of culture medium, culture medium represents less than about 20%, more preferably less than about 10%, and most preferably less than about 5% of the volume of the protein preparation. The language "substantially free of chemical precursors or other chemicals" includes preparations of MCT protein in which the protein is separated from chemical precursors or other chemicals which are involved in the synthesis of the protein. In one embodiment, the language "substantially free of chemical precursors or -47other chemicals" includes preparations of MCT protein having less than about 30% (by dry weight) of chemical precursors or non-MCT chemicals, more preferably less than about 20% chemical precursors or non-MCT chemicals, still more preferably less than about 10% chemical precursors or non-MCT chemicals, and most preferably less than about 5% chemical precursors or non-MCT chemicals. In preferred embodiments, isolated proteins or biologically active portions thereof lack contaminating proteins from the same organism from which the MCT protein is derived. Typically, such proteins are produced by recombinant expression of, for example, a C. glutamicum MCT protein in a microorganism such as C. glutamicum.

An isolated MCT protein or a portion thereof of the invention can participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or has one or more of the activities set forth in Table 1. In preferred embodiments, the protein or portion thereof comprises an amino acid sequence which is sufficiently homologous to an amino acid sequence of the invention a sequence of an even-numbered SEQ ID NO: of the Sequence Listing) such that the protein or portion thereof maintains the ability participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. The portion of the protein is preferably a biologically active portion as described herein. In another preferred embodiment, an MCT protein of the invention has an amino acid sequence set forth as an even-numbered SEQ ID NO: of the Sequence Listing.. In yet another preferred embodiment, the MCT protein has an amino acid sequence which is encoded by a nucleotide sequence which hybridizes, hybridizes under stringent conditions, to a nucleotide sequence of the invention a sequence of an odd-numbered SEQ ID NO: of the Sequence Listing). In still another preferred embodiment, the MCT protein has an amino acid sequence which is encoded by a nucleotide sequence that is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to one of the nucleic acid sequences of the invention, or a -48portion thereof. Ranges and identity values intermediate to the above-recited values, 70-90% identical or 80-95% identical) are also intended to be encompassed by the present invention. For example, ranges of identity values using a combination of any of the above values recited as upper and/or lower limits are intended to be included. The preferred MCT proteins of the present invention also preferably possess at least one of the MCT activities described herein. For example, a preferred MCT protein of the present invention includes an amino acid sequence encoded by a nucieotide sequence which hybridizes, hybridizes under stringent conditions, to a nucleotide sequence of the invention, and which can participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or which has one or more of the activities set forth in Table 1.

In other embodiments, the MCT protein is substantially homologous to an amino acid sequence of the invention a sequence of an even-numbered SEQ ID NO: of the Sequence Listing) and retains the functional activity of the protein of one of the amino acid sequences of the invention yet differs in amino acid sequence due to natural variation or mutagenesis, as described in detail in subsection I above. Accordingly, in another embodiment, the MCT protein is a protein which comprises an amino acid sequence which is at least about 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to an entire amino acid sequence of the invention and which has at least one of the MCT activities described herein. Ranges and identity values intermediate to the above-recited values, 70-90% identical or 80-95% identical) are also intended to be encompassed by the present invention. For example, ranges of identity values using a combination of any of the above values recited as upper and/or lower limits are intended to be included. In another embodiment, the invention pertains to a full length C. glutamicum protein which is substantially homologous to an entire amino acid sequence of the invention.

-49- Biologically active portions of an MCT protein include peptides comprising amino acid sequences derived from the amino acid sequence of an MCT protein, e.g., the an amino acid sequence of an even-numbered SEQ ID NO: of the Sequence Listing or the amino acid sequence of a protein homologous to an MCT protein, which include fewer amino acids than a full length MCT protein or the full length protein which is homologous to an MCT protein, and exhibit at least one activity of an MCT protein.

Typically, biologically active portions (peptides, peptides which are, for example, 10, 15, 20, 30, 35, 36, 37, 38, 39, 40, 50, 100 or more amino acids in length) comprise a domain or motif with at least one activity of an MCT protein. Moreover, other biologically active portions, in which other regions of the protein are deleted, can be prepared by recombinant techniques and evaluated for one or more of the activities described herein. Preferably, the biologically active portions of an MCT protein include one or more selected domains/motifs or portions thereof having biological activity.

MCT proteins are preferably produced by recombinant DNA techniques. For example, a nucleic acid molecule encoding the protein is cloned into an expression vector (as described above), the expression vector is introduced into a host cell (as described above) and the MCT protein is expressed in the host cell. The MCT protein can then be isolated from the cells by an appropriate purification scheme using standard protein purification techniques. Alternative to recombinant expression, an MCT protein, polypeptide, or peptide can be synthesized chemically using standard peptide synthesis techniques. Moreover, native MCT protein can be isolated from cells endothelial cells), for example using an anti-MCT antibody, which can be produced by standard techniques utilizing an MCT protein or fragment thereof of this invention.

The invention also provides MCT chimeric or fusion proteins. As used herein, an MCT "chimeric protein" or "fusion protein" comprises an MCT polypeptide operatively linked to a non-MCT polypeptide. An "MCT polypeptide" refers to a polypeptide having an amino acid sequence corresponding to an MCT protein, whereas a "non-MCT polypeptide" refers to a polypeptide having an amino acid sequence corresponding to a protein which is not substantially homologous to the MCT protein, a protein which is different from the MCT protein and which is derived from the same or a different organism. Within the fusion protein, the term "operatively linked" is intended to indicate that the MCT polypeptide and the non-MCT polypeptide are fused in-frame to each other. The non-MCT polypeptide can be fused to the N-terminus or Cterminus of the MCT polypeptide. For example, in one embodiment the fusion protein is a GST-MCT fusion protein in which the MCT sequences are fused to the C-terminus of the GST sequences. Such fusion proteins can facilitate the purification of recombinant MCT proteins. In another embodiment, the fusion protein is an MCT protein containing a heterologous signal sequence at its N-terminus. In certain host cells mammalian host cells), expression and/or secretion of an MCT protein can be increased through use of a heterologous signal sequence.

Preferably, an MCT chimeric or fusion protein of the invention is produced by standard recombinant DNA techniques. For example, DNA fragments coding for the different polypeptide sequences are ligated together in-frame in accordance with conventional techniques, for example by employing blunt-ended or stagger-ended termini for ligation, restriction enzyme digestion to provide for appropriate termini, filling-in of cohesive ends as appropriate, alkaline phosphatase treatment to avoid undesirable joining, and enzymatic ligation. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers.

Alternatively, PCR amplification of gene fragments can be carried out using anchor primers which give rise to complementary overhangs between two consecutive gene fragments which can subsequently be annealed and reamplified to generate a chimeric gene sequence (see, for example, Current Protocols in Molecular Biology, eds. Ausubel et al. John Wiley Sons: 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety a GST polypeptide). An MCTencoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the MCT protein.

Homologues of the MCT protein can be generated by mutagenesis, discrete point mutation or truncation of the MCT protein. As used herein, the term "homologue" refers to a variant form of the MCT protein which acts as an agonist or antagonist of the activity of the MCT protein. An agonist of the MCT protein can retain substantially the same, or a subset, of the biological activities of the MCT protein. An antagonist of the MCT protein can inhibit one or more of the activities of the naturally occurring form of the MCT protein, by, for example, competitively binding to a downstream or upstream member of the cell membrane component metabolic cascade which includes the MCT -51 protein, or by binding to an MCT protein which mediates transport of compounds across such membranes, thereby preventing translocation from taking place.

In an alternative embodiment, homologues of the MCT protein can be identified by screening combinatorial libraries of mutants, truncation mutants, of the MCT protein for MCT protein agonist or antagonist activity. In one embodiment, a variegated library of MCT variants is generated by combinatorial mutagenesis at the nucleic acid level and is encoded by a variegated gene library. A variegated library of MCT variants can be produced by, for example, enzymatically ligating a mixture of synthetic oligonucleotides into gene sequences such that a degenerate set of potential MCT sequences is expressible as individual polypeptides, or alternatively, as a set of larger fusion proteins for phage display) containing the set of MCT sequences therein.

There are a variety of methods which can be used to produce libraries of potential MCT homologues from a degenerate oligonucleotide sequence. Chemical synthesis of a degenerate gene sequence can be performed in an automatic DNA synthesizer, and the synthetic gene then ligated into an appropriate expression vector. Use of a degenerate set of genes allows for the provision, in one mixture, of all of the sequences encoding the desired set of potential MCT sequences. Methods for synthesizing degenerate oligonucleotides are known in the art (see, Narang, S.A. (1983) Tetrahedron 39:3; Itakura et al. (1984) Annu. Rev. Biochem. 53:323; Itakura et al. (1984) Science 198:1056; Ike et al. (1983) Nucleic Acid Res. 11:477.

In addition, libraries of fragments of the MCT protein coding can be used to generate a variegated population of MCT fragments for screening and subsequent selection of homologues of an MCT protein. In one embodiment, a library of coding sequence fragments can be generated by treating a double stranded PCR fragment of an MCT coding sequence with a nuclease under conditions wherein nicking occurs only about once per molecule, denaturing the double stranded DNA, renaturing the DNA to form double stranded DNA which can include sense/antisense pairs from different nicked products, removing single stranded portions from reformed duplexes by treatment with S nuclease, and ligating the resulting fragment library into an expression vector. By this method, an expression library can be derived which encodes N-terminal, C-terminal and internal fragments of various sizes of the MCT protein.

-52- Several techniques are known in the art for screening gene products of combinatorial libraries made by point mutations or truncation, and for screening cDNA libraries for gene products having a selected property. Such techniques are adaptable for rapid screening of the gene libraries generated by the combinatorial mutagenesis of MCT homologues. The most widely used techniques, which are amenable to high through-put analysis, for screening large gene libraries typically include cloning the gene library into replicable expression vectors, transforming appropriate cells with the resulting library of vectors, and expressing the combinatorial genes under conditions in which detection of a desired activity facilitates isolation of the vector encoding the gene whose product was detected. Recursive ensemble mutagenesis (REM), a new technique which enhances the frequency of functional mutants in the libraries, can be used in combination with the screening assays to identify MCT homologues (Arkin and Yourvan (1992) PNAS 89:7811-7815; Delgrave et al. (1993) Protein Engineering 6(3):327-331).

In another embodiment, cell based assays can be exploited to analyze a variegated MCT library, using methods well known in the art.

D. Uses and Methods of the Invention The nucleic acid molecules, proteins, protein homologues, fusion proteins, primers, vectors, and host cells described herein can be used in one or more of the following methods: identification of C. glutamicum and related organisms; mapping of genomes of organisms related to C. glutamicum; identification and localization of C glutamicum sequences of interest; evolutionary studies; determination of MCT protein regions required for function; modulation of an MCT protein activity; modulation of the metabolism of one or more cell membrane components; modulation of the transmembrane transport of one or more compounds; and modulation of cellular production of a desired compound, such as a fine chemical.

The MCT nucleic acid molecules of the invention have a variety of uses. First, they may be used to identify an organism as being Corynebacterium glutamicum or a close relative thereof. Also, they may be used to identify the presence of C. glutamicum or a relative thereof in a mixed population of microorganisms. The invention provides the nucleic acid sequences of a number of C. glutamicum genes; by probing the -53extracted genomic DNA of a culture of a unique or mixed population of microorganisms under stringent conditions with a probe spanning a region of a C glutamicum gene which is unique to this organism, one can ascertain whether this organism is present.

Although Corynebacterium glutamicum itself is nonpathogenic, it is related to pathogenic species, such as Corynebacterium diphtheriae. Corynebacterium diphtheriae is the causative agent of diphtheria, a rapidly developing, acute, febrile infection which involves both local and systemic pathology. In this disease, a local lesion develops in the upper respiratory tract and involves necrotic injury to epithelial cells; the bacilli secrete toxin which is disseminated through this lesion to distal susceptible tissues of the body. Degenerative changes brought about by the inhibition of protein synthesis in these tissues, which include heart, muscle, peripheral nerves, adrenals, kidneys, liver and spleen, result in the systemic pathology of the disease. Diphtheria continues to have high incidence in many parts of the world, including Africa, Asia, Eastern Europe and the independent states of the former Soviet Union. An ongoing epidemic of diphtheria in the latter two regions has resulted in at least 5,000 deaths since 1990.

In one embodiment, the invention provides a method of identifying the presence or activity of Cornyebacterium diphtheriae in a subject. This method includes detection of one or more of the nucleic acid or amino acid sequences of the invention the sequences set forth as odd-numbered or even-numbered SEQ ID NOs, respectively, in the Sequence Listing) in a subject, thereby detecting the presence or activity of Corynebacterium diphtheriae in the subject. C. glutamicum and C. diphtheriae are related bacteria, and many of the nucleic acid and protein molecules in C. glutamicum are homologous to C. diphtheriae nucleic acid and protein molecules, and can therefore be used to detect C. diphtheriae in a subject.

The nucleic acid and protein molecules of the invention may also serve as markers for specific regions of the genome. This has utility not only in the mapping of the genome, but also for functional studies of C. glutamicum proteins. For example, to identify the region of the genome to which a particular C. glutamicum DNA-binding protein binds, the C. glutamicum genome could be digested, and the fragments incubated with the DNA-binding protein. Those which bind the protein may be additionally probed with the nucleic acid molecules of the invention, preferably with readily detectable labels; binding of such a nucleic acid molecule to the genome fragment enables the -54localization of the fragment to the genome map of C. glutamicum, and, when performed multiple times with different enzymes, facilitates a rapid determination of the nucleic acid sequence to which the protein binds. Further, the nucleic acid molecules of the invention may be sufficiently homologous to the sequences of related species such that these nucleic acid molecules may serve as markers for the construction of a genomic map in related bacteria, such as Brevibacterium lactofermentum.

The MCT nucleic acid molecules of the invention are also useful for evolutionary and protein structural studies. The metabolic and transport processes in which the molecules of the invention participate are utilized by a wide variety of prokaryotic and eukaryotic cells; by comparing the sequences of the nucleic acid molecules of the present invention to those encoding similar enzymes from other organisms, the evolutionary relatedness of the organisms can be assessed. Similarly, such a comparison permits an assessment of which regions of the sequence are conserved and which are not, which may aid in determining those regions of the protein which are essential for the functioning of the enzyme. This type of determination is of value for protein engineering studies and may give an indication of what the protein can tolerate in terms of mutagenesis without losing function.

Manipulation of the MCT nucleic acid molecules of the invention may result in the production of MCT proteins having functional differences from the wild-type MCT proteins. These proteins may be improved in efficiency or activity, may be present in greater numbers in the cell than is usual, or may be decreased in efficiency or activity.

The invention provides methods for screening molecules which modulate the activity of an MCT protein, either by interacting with the protein itself or a substrate or binding partner of the MCT protein, or by modulating the transcription or translation of an MCT nucleic acid molecule of the invention. In such methods, a microorganism expressing one or more MCT proteins of the invention is contacted with one or more test compounds, and the effect of each test compound on the activity or level of expression of the MCT protein is assessed.

There are a number of mechanisms by which the alteration of an MCT protein of the invention may directly affect the yield, production, and/or efficiency of production of a fine chemical from a C. glutamicum strain incorporating such an altered protein.

Recovery of fine chemical compounds from large-scale cultures of C. glutamicum is significantly improved ifC. glutamicum secretes the desired compounds, since such compounds may be readily purified from the culture medium (as opposed to extracted from the mass of C. glutamicum cells). By either increasing the number or the activity of transporter molecules which export fine chemicals from the cell, it may be possible to increase the amount of the produced fine chemical which is present in the extracellular medium, thus permitting greater ease of harvesting and purification. Conversely, in order to efficiently overproduce one or more fine chemicals, increased amounts of the cofactors, precursor molecules, and intermediate compounds for the appropriate biosynthetic pathways are required. Therefore, by increasing the number and/or activity of transporter proteins involved in the import of nutrients, such as carbon sources sugars), nitrogen sources amino acids, ammonium salts), phosphate, and sulfur, it may be possible to improve the production of a fine chemical, due to the removal of any nutrient supply limitations on the biosynthetic process. Further, fatty acids and lipids are themselves desirable fine chemicals, so by optimizing the activity or increasing the number of one or more MCT proteins of the invention which participate in the biosynthesis of these compounds, or by impairing the activity of one or more MCT proteins which are involved in the degradation of these compounds, it may be possible to increase the yield, production, and/or efficiency of production of fatty acid and lipid molecules from C. glutamicum.

The engineering of one or more MCT genes of the invention may also result in MCT proteins having altered activities which indirectly impact the production of one or more desired fine chemicals from C .glutamicum. For example, the normal biochemical processes of metabolism result in the production of a variety of waste products hydrogen peroxide and other reactive oxygen species) which may actively interfere with these same metabolic processes (for example, peroxynitrite is known to nitrate tyrosine side chains, thereby inactivating some enzymes having tyrosine in the active site (Groves, J.T. (1999) Curr. Opin. Chem. Biol. 226-235). While these waste products are typically excreted, the C. glutamicum strains utilized for large-scale fermentative production are optimized for the overproduction of one or more fine chemicals, and thus may produce more waste products than is typical for a wild-type C.

gluramicum. By optimizing the activity of one or more MCT proteins of the invention which are involved in the export of waste molecules, it may be possible to improve the -56viability of the cell and to maintain efficient metabolic activity. Also, the presence of high intracellular levels of the desired fine chemical may actually be toxic to the cell, so by increasing the ability of the cell to secrete these compounds, one may improve the viability of the cell.

Further, the MCT proteins of the invention may be manipulated such that the relative amounts of various lipid and fatty acid molecules produced are altered. This may have a profound effect on the lipid composition of the membrane of the cell. Since each type of lipid has different physical properties, an alteration in the lipid composition of a membrane may significantly alter membrane fluidity. Changes in membrane fluidity can impact the transport of molecules across the membrane, which, as previously explicated, may modify the export of waste products or the produced fine chemical or the import of necessary nutrients. Such membrane fluidity changes may also profoundly affect the integrity of the cell; cells with relatively weaker membranes are more vulnerable in the large-scale fermentor environment to mechanical stresses which may damage or kill the cell. By manipulating MCT proteins involved in the production of fatty acids and lipids for membrane construction such that the resulting membrane has a membrane composition more amenable to the environmental conditions extant in the cultures utilized to produce fine chemicals, a greater proportion of the C. glutamicum cells should survive and multiply. Greater numbers of C. glutamicum cells in a culture should translate into greater yields, production, or efficiency of production of the fine chemical from the culture.

The aforementioned mutagenesis strategies for MCT proteins to result in increased yields of a fine chemical from C. glutamicum are not meant to be limiting; variations on these strategies will be readily apparent to one of ordinary skill in the art.

Using such strategies, and incorporating the mechanisms disclosed herein, the nucleic acid and protein molecules of the invention may be utilized to generate C glutamicum or related strains of bacteria expressing mutated MCT nucleic acid and protein molecules such that the yield, production, and/or efficiency of production of a desired compound is improved. This desired compound may be any natural product of C.

glutamicum, which includes the final products of biosynthesis pathways and intermediates of naturally-occurring metabolic pathways, as well as molecules which do -57not naturally occur in the metabolism of C. glutamicum, but which are produced by a C.

glutamicum strain of the invention.

This invention is further illustrated by the following examples which should not be construed as limiting. The contents of all references, patent applications, patents, published patent applications, Tables, and the sequence listing cited throughout this application are hereby incorporated by reference.

2006200795 24 Feb 2006 TABLE 1: GENES IN THE APPLICATION Nucleic Acid SEQ ID NO 3 Amino Acid Identification Code SEQ ID NO 2 RXN03097 4 RXA02099 6 RXA00104 Contig.

WV0062 GR00630 GR00014 NT Start NT Stop Function 3 6198 15895 557 AMMONIUM TRANSPORT SYSTEM 6470 AMMONIUM TRANSPORT SYSTEM 16650 CYSQ PROTEIN, ammonium transport protein Polyketide Synthesis Nucleic Acid Amino Acid SEQ ID NO SEQ ID NO 7 8 9 10 11 12 13 14 16 17 18 19 20 21 22 Identification Code RXA01420 RXN 02581 F RXA02581 RXA02582 RXAO1 138 RXA01 980 RXN01 007 RXN00784 Contig.

GR00416 W0098 GR00741 GR00741 GR00318 GR00573 W0021 W01 03 NT Start NT Stop Function 775 30482 1890 1656 1470 2572 27531 17 28623 1527 6719 2072 838 66 28265 4-MYCAROSYL ISO VALERYL-COA TRANSFERASE (EC POLYKETIDE SYNTHASE POLYKETIDE SYNTI-ASE PROBABLE POLYKETIDE SYNTHASE CY338.20 ACTINORHODIN POLYKETIDE DIMERASE (EC POLYKETIDE CYCLASE

FRNA

FRNE

Fatty acid and lipid synthesis Nucleic Acid SEQ ID NO 23 27 29 31 33 37 39 41 43 Amino Acid Identification Code SEQ ID NO 24 RXA02335 26 RXA02173 Contig. NT Start NT Stop Function RXA01764 RXN02487 F RXA02487 F RXA02490 RXA01 467 RXA00796 RXA01897 RXN02809 F RXA02809 RXN001 13 F RXAOO1 13 GR00672 550 2322 BIOTIN CARBOXYLASE (EC 6.3.4.14) GR00641 7473 8924 ACIETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA (EC 6.4.1.2) GROO500 2178 3110 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE (EC 1.1.1.100) W0007 6367 4664 LONG-CHAIN-FATTY-ACID-COA LIGASE (EC, 6.2.1.3) GR00718 4937 4650 LONG-CHAIN-FATTY-ACID-COA LIGASE (EC 6.2.1.3) GR00720 817 5 LONG-CHAIN-FATTY-ACID-OA LIGASE (EC 6.2.1.3) GR00422 920 1210 ACYL CARRIER PROTEIN GR00212 202 5 Acyl carrier protein phasphodiesterase GRO0544 617 1159 Acyl carrier protein phosphodiesterase WV0342 380 6 Acyl cardier protein phosphodiesterase GR00790 277 5 Acyl cardier protein phosphodiesterase W0129 103 5724 FATTY ACID SYNTHASE (EC 2.3.1.85) [INCLUDES: EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; CR00017 2 3295 FATTY-ACID SYNTHASE (EC 2.3.1.85) 2006200795 24 Feb 2006 Table 1 (continued) Nucleic Acid Amino Acid Identification Code Contig. NT Start NT Stop Function SEQ ID NO SEQ ID NO 49 50 RXN031 11 W0084 6040 5 FATTY ACID SYNTH-ASE (EC 2.3.1.85) (INCLUDES: EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 1.1.1.100: EC 4.2.1.61; EC 1.3.1.10; EC 3.1.2.14] 51 52 F RXA00158 CR00024 2088 4 FATTY ACID SYNTHASE (EC 2.3.1.85) 53 54 F RXA00572 GR00155 2 3832 FATTY ACID SYNTHASE (EC 2.3.1.85) 56 RXA02582 GR00741 1890 6719 PROBABLE POLYKETIDE SYNTHASE CY338.20 57 58 RXA02691 GR00754 15347 14541 FATTY ACYL RESPONSIVE REGULATOR 59 60 RXA00880 GR00242 6213 8057 LONG-CHAIN-FATTY-ACID-COA LIGASE (EC 6.2.1.3) 61 62 RXA01060 GR00296 9566 10489 OMEGA-3 FATTY ACID DESATURASE (EC 1.14.99.-) 63 64 RXN01722 W0036 2938 1214 MEDIUM-CHAIN-FATTY-ACID-COA LICASE (EC 6.2.1 66 F RXA01722 CR00488 5746 4022 MEDIUM-CHAIN-FATTY-ACID-COA LIGASE (EC 6.2.1 67 68 RXA01644 GR00456 9854 .8577 CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE (EC 2.1.1.79) 69 70 RXA02029 CR0061 8 356 1669 CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE (EC 2.1.1.79) 71 72 RXAO18O1 GR00509 3396 2380 ENOYL-COA HYDRATASE (EC 4.2.1.17) 73 74 RXN02512 W0171 16147 15185 LIPID A BIOSYNTHESIS LAUROYL ACYLTRANSFERASE (EC 76 F RXA02512 CR00721 3303 4259 LIPID A BIOSYNTHESIS LAUROYL ACYLTRANSFERASE (EC 2.3.1l.-) 77 78 RXA00899 CR00245 1599 2864 CARDIOLIPIN SYNTHE1TASE (EC 79 80 RXN00819 W0054 18127 19455 ACYL-COA DEHYDROCENASE (EC 1.3.99.-) 81 82 F RXA00819 CR00221 18 1007 ACYL-COA DEHYDROCENASE (EC 1.3.99.-) 83 84 F RXA01766 CR00500 4081 4371 ACYL-COA DEHYDROCENASE (EC 1.3.99.-) 86 RXN01762 W0054 15318 13783 LONG-CHAIN-FATTY-ACID-COA LIGASE (EC 6.2.1.3) 87 88 F RXA01762 CR00500 1272 10 LONG-CI-AIN-FATTY-ACID-COA LIGASE (EC 6.2.1.3) 89 90 RXA00681 CR001 79 3405 .2662 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE (EC 1.1. 1. 100) 91 92 RXA00802 CR00214 3803 4516 3-OXOACYL-(ACYL-CARRIER PROTEIN] REDUCTASE (EC 1.1.1.100) 93 94 RXA02133 CR00639 3 308 3-OXOACYL-[ACYL-CARRIER PROTEIN) REDUCTASE (EC 1.1.1.100) 96 RXN01 114 W0182 9118 10341 3-KETOACYL-COA THIOLASE (EC 2.3.1.16) 97 98 F RXAl1I1 4 CR00308 2 793 3-KETOACYL-COA THIOLASE (EC 2.3.1.16) 99 100 RXA01 894 CR00542 1622 2476 PHOSPHATIDATE CYTIDYLYLTRANSFERASE (EC 2.7.7.4 1) 101 102 RXA02599 CR00742 3179 3655 PHOSPHATIDYLGLYCEROPHOSPHATASE B (EC 3.1.3.27) 103 104 RXN02638 W0098 5.4531 53656 1-ACYLSN-GLYCEROL-3-PHOSPH-ATE ACYLTRANSFERASE (EC 2.3.1.51) 105 106 F RXA02638 GR00749 8 511 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE (EC 2.3.1.51) 107 108 RXA00856 CR00232 720 1256 CDP-DIACYLGLYCEROL--CLYCEROL-3-PHOSPHATE 3- PIIOSPHATIDYLTRANSFERASE (EC 2.7.8.5) 109 110 RXA02511 CR00721 2621 3277 CDP-DIACYLCLYCEROL-GLYCEROL-3-PHOSPHATE 3- PHOSPHATIDYLTRANSFERASE (EC 2.7.8.5) Ill 112 RXN02836 W0102 32818 33372 KETOACYL REDUCTASE HETN (EC 113 114 F RXA02836 CR00827 106 411 KETOACYL REDUCTASE HETN (EC 115 116 RXA02578 GR00740 2438 3541 PUTATIVE ACYLTRANSFERASE 117 118 RX.A021 50 CR00639 18858 19658 1 -ACYL-SN-GLYCEROL-3-PHOSPH-ATE ACYLTRANSFERASE (EC 2.3.1.51) 119 120 RXA0O607 CR00160 1869 2249 POLY(3-HYDROXYALKANOATE) POLYMERASE (EC 121 122 RXA02397 CR00698 1688 2683 POLY-13ETA-HYDROXYBUTYRATE POLYMERASE (EC 123 124 RXN031 10 W0083 16568 17929 HYDROXYACYLCLUTATHIONE HYDROLASE (EC 3.1.2.6) 125 126 F RXA00660 CR00171 1027 5 HYDROXYACYLCLUTATHIONE HYDROLASE (EC 3.1.2.6) 127 128 RXAOO8O1 CR00214 3138 3770 HYDROXYACYLCLUTATHIONE H-YDROLASE (EC 3.1.2.6) 129 130 RXA00821 CR00221 1469 2311 HYDROXYACYLCLUTATHIONE HYDROLASE (EC 3.1.2.6) 131 132 RXN02966 W0143 12056 13462 HYDROXYACYLGLUTATHIONE HYDROLASE (EC 3.1.2.6) 133 134 F RXA01833 CR00517 1666 260 HYDROXYACYLCLUTATHIONE HYDROLASE (EC 3.1.2.6) 135 136 RXA01853 CR00525 5561 5010 HYDROXYACYLGLUTATHIONE HYDROLASE (EC 3.1.2.6) 2006200795 24 Feb 2006 Table I (continued) Nucleic Acid Amino Acid Identification Code Contig. NT Start NT Stop Function SEQ ID NO SEQ ID NO 137 138 RXN02424 W01 16 10570 11169 HYDROXYACYLGLUTATHIONE HYDROLASE (EC 3.1.2.6) 139 140 F RXA02424 GR00706 808 428 H-YDROXYACYLGLUTATHIONE HYDROLASE (EC 3.1.2.6) 141 142 RXN00419 VV01 12 1024 266 ACETOACETYL-COA REDUCTASE (EC 1.1.1.36) 143 144 F RXA00419 GRO0095 3 464 ACETOACETYL-COA REDUCTASE (EC 1. 1. 1.36) 145 146 F RXA00421 GR00096 565 723 ACETOACETYL-COA REDUCTASE (EC 1.1.1.36) 147 148 RXN02923 W0088 3301 2564 ACETOACETYL-COA REDUCTASE (EC 1.1.1.36) 149 150 RXN02922 WV0321 11407 10328 ACYL-COA DEHYDROGENASE, SHORT-CHAIN SPECIFIC (EC 1.3.99.2) 151 152 RXN03065 W0038 6237 6629 HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE (EC 2.7.8.7) 153 154 RXN03132 W0127 39053 39472 POLY-BETA-HYDROXYBUTYRATE POLYMERASE (EC 155 156 RXN03157 W0188 1607 1170 LIPOPOLYSACCHARIDE CORE BIOSYNTHESIS PROTEIN KDTB 157 158 RXN00934 W0171 15181 14099 (AE000805) LPS biosynthesis RfbU related protein [Methanobacterium thermoautotrophicum] 159 160 RXN00792 W0321 10328 9132 ACYL-COA DEHYDROGENASE, SHORT-CHAIN SPECIFIC (EC 1.3.99.2) 161 162 RXN00931 W0171 '13011 12166 ACYL-COA THIOESTERASE 11 (EC 163 164 F RXA00931 GR00253 4959 4114 thioesterase 11 165 166 RXN01421 W0122 16024 15638 ACYLTRANSFERASE (EC 167 168 RXN02342 W0078 3,460 4266 BIOTIN-[ACETYL-COA-CARBOXYLASE] SYNTHETASE (EC 6.3.4.15) 169 170 RXN00563 W0038 1 2739 FATTY ACID SYNTHASE (EC 2.3.1.85) [INCLUDES: EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 1.1.1.100; EC 4.2.1.61; EC 1.3.1.10; EC 3.1.2.141 171 172 RXN02168 WO100 2894 81 FATTY ACID SYNTHASE (EC 2..3.1.85) [INCLUDES: EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 1. 1. 1.100; EC 4.2.1.61; EC 1.3. 1. 10; EC 3.1.2.14] 173 174 RXN01090 WV0155 6483 5685 KETOACYL REDUCTASE HETNI (EC 175 176 RXN02062 WV0222 3159 1990 Lipopolysaccharide N-acetylglucosaminyltransferase 177 178 RXN02148 W0300 16561 17703 Lipopolysacch aride N-acetylglucosaminyltransferase 179 180 RXN02595 W0098 11098 9935 Lipopolysaccharide N-acetylglucosaminyltransferase 181 182 RXS00148 W0167 9849 12059 METHYLMALONYL-COA MUTASE ALPHA-SUBUNIT (EC 5.4.99.2) 183 184 RXS00149 W0167 7995 9842 METHYLMALONYL-COA MUTASE BETA-SUBUNIT (EC 5.4.99.2) 185 186 RXS02106 W0123 22649 21594 LIPOATE-PROTEIN LIGASE A (EC 187 188 RXS01746 W0185 934 1686 LIPOATE-PROTEIN LIGASE B (EC 189 190 RXS01 747 W0185 1826 2869 LIPOIC ACID SYNTHETASE 191 192 RXCO1 748 WV0185 3001 3780 protein involved in lipid metabolism 193 194 RXC00354 W0135 33604 32792 Cytosolic Protein involved in lipid metabolism 195 196 RXC01749 W0185 3953 5569 Membrane Spanning Protein involved in lipid metabolism Fatty acid degradation Nucleic Acid Amino Acid Identification Code Contig. NT Start NT Stop Function SEQ ID NO SEQ ID NO 197 198 RXA02268 GRO0655 2182 3081 LIPASE (EC 3.1.1.3) 199 200 RXA02269 GR00655 3094 4065 LIPASE (EC 3.1.1.3) 201 202 RXA01614 GR00449 8219 7197 LYSOPHOSPHOLIPASE 12 (EC 3.1.1.5) 203 204 RXA01983 GR00573 3559 3053 LIPASE (EC 3.1.1.3) 205 206 RXN02947 W0078 1319 6 PROPIONYL-COA CARBOXYLASE BETA CHAIN (EC 6.4.1.3) 207 208 F RXA02320 GR00667 593 6 PROPIONYL-COA CARBOXYLASE BETA CHAIN (EC 6.4.1.3) 209 210 F RXA02851 GROO851 524 6 PROPIONYL-COA CARBOXYLASE BETA CHAIN (EC 6.4.1.3) 211 212 RXN02321 W0078 3291 1663 PROPIONYL-COA CARBOXYLASE BETA CHAIN (EC 6.4.1.3) 2006200795 24 Feb 2006 Table 1 (continued) NT Start NT Stop Function Nucleic Acid SEQ ID NO 213 215 217 219 221 Amino Acid SEQ ID NO 214 216 218 220 222 Identification Code F RXA02321 F RXA02343 F RXA02850 RXA02583 RXA00870 GROO567 GRO0675 GRD0850 GR00741 GR00239 GR00367 223 224 225 226 RXA01260 RXA01 261 RXAO1 138 RXN00559 F RXA00559 RXA01 580 RXA02677 RXS01 166 937 PROPIONYL-OA CARBOXYLASE BETA CHAIN (EC 6.4.1.3) 1816 PROPIONYL-COA CARBOXYLASE BETA CHAIN (EC 6.4.1.3) 493 PROPIONYL-COA CARBOXYLASE BETA CHAIN (EC. 6.4.1.3) 8290 PROPIONYL-COA CARBOXYLASE BETA CHAIN (EC 6.4.1.3) 2320 METHYLMALONATE-SEMIALDEHYDE DEHYOROGENASE (ACYLATING) (EC 1.2.1.27) 2-Methyl-3-oxopropanoate:NAD+ oxidloreductase, (CoA-propanoylating) 1200 LIPOAMIDE DEHYDROGENASE COMPONENT (E3) OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX (EC 1.8.1.4) 2437 LIPOAMIDE DEHYDROGENASE COMPONENT (E3) OF BRANCHED-CHAIN AIPHA-KETO ACID DEHYOROGENASE COMPLEX (EC 1.8.1.4) 1116 ISOVALERYL-COA DEHYOROGENASE (EC 1.3.99. 6552 PROTEIN VDLD 6 PROTEIN VOLD 6 Glycerophosphoryl diester phosphodiesterase 3877 GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE (EC 3.1.4.46) 16838 EXTRACELLULAR LIPASE PRECURSOR (EC 3.1.1.3) GR00367 2607 GR0031 8 685 W0103 7568 GR00149 218 GR00440 707 GR00754 3119 W01 17 18142 Terpenoid biosynthesis Nucleic Acid SEQ ID NO 239 241 243 245 247 249 251 Amino Acid SEQ ID NO 240 242 244 246 248 250 252 Identification Code RXA00875 RXA01292 RXA01 293 RXA0231 0 RXA0271 8 RXA01067 RXA01269 253 254 RXA01 205 RXA0 1576 R.XN02309 F RXA02309 RXN00477 F RXA00477 RXA00478 RXA01291 RXAOO480 RXS01 879 RXS02023 RXS00948 RXS02228 RXCO1 971 RXC02697 Contig.

GR00241 GR00373 GR00373 GR00665 GR00758 GR00298 GR00367 GR00346 GR00438 W0025 GR00665 W0086 GROWl 19 GROOI 19 GR00373 GROWl 19 W0105 W0160 W0107 W0068 wo105 W0017 2423 1204 2370 1132 18539 1453 20334 3 8053 28493 978 38905 13187 14020 345 174.44 1505 3234 4266 1876 4545 31257 1857 2388 2696 2394 19585 2181 19894 533 8811 29542 4 37262 11544 13190 1277 16329 573 4001 5384 2778 3715 32783 NT Start NT Stop Function ISOPENTENYL-DI PHOSPHATE DELTA-ISOMERASE (EC 5.3.3.2) PHYTOENE DEHYDROGENASE (EC PHYTOENE DEI-YDROGENASE (EC GERANYLGERANYL HYDROGENASE GERANYLGERANYL PYROCPHOSPHATE SYNTHASE (EC 2.5.1.1) undecaprenyl-diphosphate synthase (EC 2.5.1.31) UNDECAPRENYL-PHOSPHATE GALACTOSEPHOSPHOTRANSFERASE (EC 2.7.8.6) PUTATIVE UNDECAPRENYL-PHOSPHATE ALPHA-N- ACETYLGLUCOSAMINYLTRANSFERASE (EC DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE (EC 2.4.1.117) OCTAPRENYL-DIPHOSPHATE SYNTHASE (EC OCTAPRENYL-DIPHOSPHATE SYNTHASE (EC PHYTOENE DEHYDROGENASE (EC PHYTOENE DEHYDROGENASE (EC PHYTOENE SYNTHASE (EC PHYTOENE SYNTHASE (EC FARNESYL DIPHOSPHATE SYNTHASE (EC 2.5.1.1) (EC 2.5.1.10) isopentenyl-phosphate kinase (EC P450 cytochrome,isopentenyltransf, ferridox 1 2-oxophytodienoate red uctase (EC 1.3.1.42) TRNA DELTA(2)-ISOPENTENYLPYROPHOSPHATE TRANSFERASE (EC 2.5.1.8) Metal-Dependent H-ydrolase involved in metabolism of terpenoids membrane protein involved in metabolism of terpenoids 2006200795 24 Feb 2006 Table 1 (continued) ABC-Transporter Nucleic Acid Amino Acid Identification Code Contig. NT Start NT Stop Function SEQ ID NO SEQ ID NO 283 284 RXN01946 W0228 2 1276 Hypothetical ABC Transporter ATP-Binding Protein 285 286 F RXA01 946 GR00559 1849 575 (AL021 184) ABC transporter ATP binding protein [Mycobacterium tuberculosis] 287 288 RXN00164 W0232 1782 94 Hypothetical ABC Transporter ATP-Bindirrg Protein 289 290 F RXA00 164 GROO025 1782 94 P, G, R ATPase subunits of ABC transporters 291 292 RXN00243 WV0057 28915 27899 P, G, R ATPase subunits of ABC transporters 293 294 F RXA00243 GROO037 930 4 P. G, R ATPase subunits of ABC transporters 295 296 RXA00259 GRO0039 8469 6268 P, G, R ATPase subunits of ABC transporters 297 298 RXN00410 WV0086 51988 51323 GLUTAMINE TRANSPORT ATP-BINDING PROTEIN GLNQ 299 300 F RXA00410 GR00092 829 164 P, G, R ATPase subunits of ABC transporters 301 302 RXN00456 W0076 6780 8156 P, G, R ATPase subunits of ABC transporters 303 304 F RXA00456 GRO01 14 316 5 P. G, R ATPase subunits of ABC transporters 305 306 F RXA00459 GROWl15 1231 245 P, G. R ATPase subunits of ABC transporters 307 308 RXN01604 W0137 8117 7470 P, G, R ATPase subunits of ABC transporters 309 310 F RXAO 1604 GR00448 2 607 P, G, R ATPase subunits of ABC transporters 311 312 RXN02547 WV0057 27726 25588 P. G. R ATPase subunits of ABC transporters 313 314 F RXA02547 GR00726 22055 19932 P. G. R ATPase subunits of ABC transporters 315 316 RXN02571 W0101 12331 13359 MALTOSE/MALTODEXTRIN TRANSPORT ATP-BINDING PROTEIN MALK 317 318 F RXA02571 GR00736 1469 2497 G. R ATPase subunits of ABC transporters 319 320 RXN02074 W0318 12775 11153 TRANSPORT ATP-BINDING PROTEIN CYDD 321 322 F RXA02074 GR00628 5798 4176 P. G, R ATPase subunits of ABC transporters 323 324 RXA02095 GR00629 14071 15474 P, G, R ATPase subunits of ABC transporters 325 326 RXA02225 GR00652 3156 2275 P, G, R ATPase subunits of ABC transporters 327 328 RXA02253 GROD654 20480 21406 P. G. R ATPase subunits of ABC transporters 329 330 RXNO118811 WV0l0 529 95 Hypothetical ABC Transporter ATP-Binding Protein 331 332 F RXA01 881 GR00537 3092 3532 ATPase components of ABC transporters with duplicated ATPase domains 333 334 RXA00526 GROOI 36 1353 664 Hypothetical ABC Transporter ATP-Binding Protein 335 336 RXN00733 W0132 1647 2531 Hypothetical ABC Transporter ATP-Binding Protein 337 338 F RXA00733 GROWl 97 411 4 Hypothetical ABC Transporter ATP-Binding Protein 339 340 RXA00735 GR00198 849 181 Hypothetical ABC Transporter ATP-Binding Protein 341 342 RXA00878 GR00242 3733 1871 Hypothetical ABC Transporter ATP-Binding Protein 343 344 RXN01I191 W0169 10478 12067 Hypothetical ABC Transporter ATP-Binding Protein 345 346 F RXAO 1191 GR00341 1571 165 Hypothetical ABC Transporter ATP-Binding Protein 347 348 RXN01212 W0169 3284 4207 Hypothetical ABC Transporter ATP-Binding Protein 349 350 F RXA01212 GR00350 1 813 Hypothetical ABC Transporter ATP-Binding Protein 351 352 RXA02749 GR00764 4153 5028 Hypothetical ABC Transporter ATP-Binding Protein 353 354 RXA02224 GR00652 2271 475 Hypothetical ABC Transporter ATP-Binding Protein 355 356 RXN01602 W0229 1109 2638 Hypothetical ABC Transporter ATP-Binding Protein 357 358 RXN02515 W0087 962 1717 Hypothetical ABC Transporter ATP-Binding Protein 359 360 RXN00525 W0079 26304 27566 Hypothetical ABC Transporter Permease Protein 361 362 RXN02096 W0126 20444 22135 Hypothetical ABC Transporter Permease Protein 363 364 RXN0041 2 W0086 53923 52844 Hypothetical Amino Acid ABC Transporter ATP-Binding Protein 365 366 RXN0O41 1 W0086 52844 52170 Hypothetical Amino Acid ABC Transporter Permease Protein 367 368 RXN02614 W0313 5964 5236 TAURINE TRANSPORT ATP-BINDING PROTEIN TAUB 369 370 RXN02613 WV0313 5223 4267 TAURINE-BINDING PERIPLASMIC PROTEIN PRECURSOR 2006200795 24 Feb 2006 Nucleic Acid SEC ID NO 371 373 375 377 379 381 383 385 387 389 391 393 395 Amino Acid SEQ ID NO 372 374 376 378 350 382 384 386 388 390 392 394 396 Identification Code Contig.

Table 1 (continued) NT Start NT Stop Function RXN00368 F RXA00368 F RXA00370 RXN01285 RXN00523 RXN01 142 RXN01 141 RXN01002 RXN01 000 RXN01 732 RXN03080 RXN03081 RXN03082 WV0226 GROO076 GROO077 W021 5 WV01 94 WV0077 W0077 W01l06 W0106 W0106 W0045 W0045 WV0045 2300 6 1780 1363 5805 4644 8858 7252 9944 1670 2476 3131 SPERMIDINEJPUTRESCINE TRANSPORT ATP-BINDING PROTEIN POTA SPERMIDINE/PUTRESCINE TRANSPORT ATP-BINDING PROTEIN POTA SPERMIDINEIPUTRESCINE TRANSPORT ATP-BINDING PROTEIN POTA FERRIC ENTEROBACTIN TRANSPORT ATP-BINDING PROTEIN FEPC FERRIC ENTEROBACTIN TRANSPORT PROTEIN FEPG NITRATE TRANSPORT ATP-BINDING PROTEIN NRTD NITRATE TRANSPORT PROTEIN NRTA PHOSPHONATES TRANSPORT ATP-BI1NDING PROTEIN PHNC PHOSPHONATES TRANSPORT SYSTEM PERMEASE PROTEIN PHNE PHOSPHONATES-BINDING PERIPLASMIC PROTEIN PRECURSOR FERRIC ENTEROBACTIN TRANSPORT ATP-BINDING PROTEIN FEPO FERRIENTEROBACTIN-BINDING PERIPLASMIC PROTEIN PRECURSOR FERRIENTEROBACTIN-BINDING PERIPLASMIC PROTEIN PRECURSOR Other transporters Nucleic Acid SEQ ID NO 397 399 401 403 405 407 409 411 413 415 417 419 421 423 425 427 429 431 433 435 437 439 441 443 445 447 449 Amino Acid SEQ I D NO 398 400 402 404 406 408 410 412 414 416 418 420 422 424 426 428 430 432 434 436 438 440 442 444 446 448 450 Identification Code RXA02261 RXA02020 RXA00281 RXN00570 F RXA00570 RXN00571 F RXA00571 RXA00962 RXA02811I RXA021 15 RXN00590 F RXA00590 F RXAO 1538 RXA01727 RXA00623 RXA01 584 RXA00852 RXA00690 RXA00827 RXA00851 RXS03220 F RXA02762 RXN00092 F RXA00092 RXN03060 F RXA02618 F RXA02900 Contig.

GR00654 GROO61 3 GR00043 W0147 GROO1 53 W0O173 GROO154 GR00268 GR00792 GR00635 W0178 GR00157 GR00427 GR00489 GROO1 63 GR00441 GR00231 GROO181 GR00223 GR00231 GR00768 W01 29 GROO014 W0030 GR00745 GRI00 NT Star NT Stop 30936 1015 4721 855 1 1298 2 2 177 2 5043 178 5040 1471 6525 55 3137 1213 1319 2448 348 27509 6227 1914 2979 32291 5 5404 4 498 42 1186 667 560 1198 6230 564 5429 194 7862 597 2448 68 567 1840 630 26844 204 5376 2351 2128 Function AMMONIUM TRANSPORT SYSTEM AROMATIC AMINO ACID TRANSPORT PROTEIN AROP BACITRACIN TRANSPORT ATP-BINDING PROTEIN BCRA BENZOATE MEMBRANE TRANSPORT PROTEIN BENZOATE MEMBRANE TRLANSPORT PROTEIN BENZOATE MEMBRANE TRANSPORT PROTEIN BENZOATE MEMBRANE TRANSPORT PROTEIN BENZOATE MEMBRANE TRANSPORT PROTEIN BENZOATE MEMBRANE TRANSPORT PROTEIN BENZOATE MEMBRANE TRANSPORT PROTEIN BRANCHED CHAIN AMINO ACID TRANSPORT SYSTEM 11 CARRIER PROTEIN B3RANCHED CHAIN AMINO ACID TRANSPORT SYSTEM 11 CARRIER PROTEIN BRANCHED CHAIN AMINO ACID TRANSPORT SYSTEM 11 CARRIER PROTEIN BRANCHED-CHAIN AMINO ACID TRANSPORT SYSTEM CARRIER PROTEIN C4-DICARBOXYLATE TRANSPORT PROTEIN CHROMATE TRANSPORT PROTEIN COBALT TRANSPORT ATP*BINDING PROTEIN COBALT TRANSPORT PROTEIN CB31Q COBALT TRANSPORT PROTEIN COBALT TRANSPORT PROTEIN CBIQ D-XYLOSE-PROTON SYM PORT D-XYLOSE PROTON-SYMPORTER GLUTAMINE TRANSPORT ATP-BINDING PROTEIN GLNQ GLUTAMINE TRANSPORT ATP-BINDING PROTEIN GINO GLUTAMINE TRANSPORT ATP-BINDING PROTEIN GINO GLUTAMINE TRANSPORT ATP-BINDING PROTEIN GINO GLUTAMINE TRANSPORT ATP-BINDING PROTEIN GLNO 2006200795 24 Feb 2006 Table I (continued) Nucleic Acid Amino Acid Identification Code C22t!2; NT Start NT Slap Function SEQ ID NO SEQ ID NO 451 452 RXS03212 GLYCINE BETAINE TRANSPORTER BETP 453 454 F RXA01591 GR00446 3 947 GLYCINE BETAINE TRANSPORTER BETP 455 456 RXN00201 WV0096 197 6 HIGH AFFINITY RIBOSE TRANSPORT PROTEIN RBSD 457 458 F RXA00201 GROO032 191 6 HIGH AFFINITY RIBOSE TRANSPORT PROTEIN RBSD 459 460 RXA01 221 GR00354 2108 2833 HIGH-AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT ATP-BINDING PROTEIN BRAG 461 462 RXA01 222 GR00354 2844 3542 HIGH-AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT ATP-BINDING PROTEIN LIVF 463 464 RXA01219 GR00354 151 1032 HIGH-AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT PERMEASE PROTEIN LIVH 465 466 RXAO1 220 GR00354 1032 2108 HIGH-AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT PERMEASE PROTEIN LIVMV 467 468 RXA00091 GROO013 7762 8514 IRON(II) DICITRATE TRANSPORT ATP-BINDING PROTEIN FECE 469 470 RXA00228 GR00032 29232 28642 IRON(II) DICITRATE TRANSPORT ATP-BINDING PROTEIN FECE 471 472 RXA00346 GR00064 1054 1743 IRON(III) DICITRATE TRANSPORT ATP-BINDING PROTEIN FECE 473 474 RXA00524 GROO1 35 779 1111 IRON(II) DICITRATE TRANSPORT ATP-BINDING PROTEIN FECE 475 476 RXA01 823 GROO516 591 1367 IRON(II) DICITRATE TRANSPORT ATP-BINDING PROTEIN FECE 477 478 RXA02767 GR00770 1032 1814 IRON(II) DICITRATE TRANSPORT ATP-BINDING PROTEIN FECE 479 480 RXA02792 GR00777 8581 7829 IRON(II) DICITRATE TRANSPORT ATP-BINDING PROTEIN FECE 481 482 RXN02929 WV0090 36837 37874 IRON(II) DICITRATE TRANSPORT SYSTEM PERMEASE PROTEIN FECD 483 484 F RXA01235 GR00358 1165 194 IRON(III) DICITRATE TRANSPORT SYSTEM PERMEASE PROTEIN FECO 485 486 RXN02794 VV0134 10625 9552 IRON(IIII DICITRATE TRANSPORT SYSTEM PERMEASE PROTEIN FECD 487 488 F RXA01419 GR00415 888 1151 IRON(III) DICITRATE TRANSPORT SYSTEM PERMEASE PROTEIN FECO 489 490 F RXA02794 GR00777 10172 9552 IRON(II) DICITRATE TRANSPORT SYSTEM PERMEASE PROTEIN FECD 491 492 RXN03079 W0045 644 1660 IRON(II) DICITRATE TRANSPORT SYSTEM PERMEASE PROTEIN FECD 493 494 F RXA02865 GR10007 3832 2816 IRON(III) DICITRATE TRANSPORT SYSTEM PERMEASE PROTEIN FECD 495 496 RXA00181 GR00028 3954 2383 PROLINE TRANSPORT SYSTEM 497 498 RXA00591 GR00158 229 1581 PROLINEJBETAINE TRANSPORTER 499 500 RXA01629 GR0D453 3476 1965 PROLINE/BETAINE TRANSPORTER 501 502 RXA02030 GR00618 3072 1687 PROLINE/BETAINE TRANSPORTER 503 504 RXA001 86 GR00028 12242 12988 SHORT-CHAIN FATTY ACIDS TRANSPORTER 505 506 RXAOO 187 GR00028 13097 13447 SHORT-CHAIN FATTY ACIDS TRANSPORTER 507 508 RXA01 667 GR00464 703 1908 SODIUM/GLUTAMATE SYMPORT CARRIER PROTEIN 509 510 RXA02171 GR00641 6571 4919 SODIUM/PROLINE SYMPORTER 511 512 RXA00902 GR00245 4643 5875 SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 513 514 RXA00941 GR00257 1999 683 sodium-dependent phosphate transport protein 515 516 RXN00449 W01 12 30992 32572 Sodium-Dicarboxylate Symport Protein 517 518 F RXA00449 GR00109 2040 1036 Sodium-Dicarboxylate Symport Protein 519 520 F RXA01 755 GR00498 352 5 Sodium-Dicarboxylate Symport Protein 521 522 RXA00269 GROO041 1826 1038 SPERMIDINEiPUTRESCINE TRANSPORT ATP-BINDING PROTEIN POTA 523 524 RXA00369 GR00076 583 1299 SPERMIDINE/PUTRESCINE TRANSPORT ATP-BINDING PROTEIN POTA 525 526 RXA02073 GR00628 4176 2647 TRANSPORT ATP-BINDING PROTEIN CYDC 527 528 RXA01399 GR00409 1 1119 TRANSPORT ATP-BINOING PROTEIN CYD 529 530 RXA01339 GR00389 6408 7164 TYROSINE-SPECIFIC TRANSPORT PROTEIN 531 532 RXA02527 GR00725 5519 6847 2-OXOGLUTARATE/MALATE TRANSILOCATOR PRECURSOR 533 534 RXN00298 W0176 40228 42072 HIGH-AFFINITY CHOLINE TRANSPORT PROTEIN 535 536 F RXA00298 GR00048 4459 6303 EctoinelProline/Glycine betaine carrier ectP 2006200795 24 Feb 2006 Nucleic Acid Amino Acid Identification Code SEQ ID NO SEQ ID NO 537 538 RXA00596 Contig- Table I (continued) NT Start NT Stop Function 539 540 RXA02364 RXN0141 1 RXN00960 RXN02447 RXN02395 RXN02348 RXN00297 RXN03 103 RXN02993 RXN00349 RXN03095 RXN03160 RXN02955 RXN03109 RXN02979 RXN02987 RXN03084 RXN03183 RXNO1 139 RXN00378 RXN01 338 RXN00980 RXN 00099 RXN02662 RXN02442 RXN02443 RXN00842 F RXA00842 RXN00832 RXN00466 RXN01936 RXN0I 995 RXN00661 GR00159 335 GR00686 841 VV0050 26015 W0075 1139 W0107 14297 VV0176 16747 VV0078 6027 VV0176 38630 W0070 845 W0071 736 W0135 35187 W0057 4056 W0189 5150 W0176 8666 W0082 659 W0149 2150 W0234 527 W0048 900 W0372 1 WV0077 2776 W0223 8027 W0032 2 WV0149 2635 VV0129 18876 W0315 1461 W0217 5970 W0217 6818 W0138 8686 GR00228 3208 VV0180 3133 W0086 63271 VV0127 40116 W01 82 2139 W0142 9718 787 215 26779 105 13203 14858 7910 39541 1087 65 36653 4424 5617 9187 6 2383 294 1817 417 1823 5418 1903 4428 17704 1724 6818 7771 7487 2009 4182 64266 41387 3476 9029 potassium efflux system protein phaE C4-DICARBOXYLATE-BINDING PERIPLASMIC PROTEIN PRECURSOR, transport protein SHIKIMATE TRANSPORTER PROTON/SODIUM-GLUTAMATE SYMPORT PROTEIN GALACTOSE-PROTON SYMPORT GLYCINE BETAINE TRANSPORTER BETP KUP SYSTEM POTASSIUM UPTAKE PROTEIN Hypothetical Malonate Transporter GLUTAMATE-BINDING PROTEIN PRECURSOR GLUTAMINE-BINDING PROTEIN Hypothetical Trehalose Transport Protein CADMIUM EFFLUX SYSTEM ACCESSORY PROTEIN HOMOLOG CHROMATE TRANSPORT PROTEIN DICARBOXYLATE TRANSPORTER HEMIN TRANSPORT SYSTEM PERMEASE PROTEIN HMUU MERCURIC TRANSPORT PROTEIN PERIPLASMIC COMPONENT PRECURSOR MERCURIC TRANSPORT PROTEIN PERIPLASMIC COMPONENT PRECURSOR IRON(III) DICITRATE-BINDING PERIPLASMIC PROTEIN PRECURSOR TREHALOSE/MALTOSE BINDING PROTEIN CATION EFFLUX SYSTEM PROTEIN CZCD Cation transport ATPases CATION-TRANSPORTING ATPASE PACS (EC 3.6. CATION-TRANSPORTING P-TYPE ATPASE B (EC CYANATE TRANSPORT PROTEIN CYNX DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPC zinc transport system membrane protein zinc-binding periplasmic protein precursor BRANCHED CHAIN AMINO ACID TRANSPORT SYSTEM 11 CARRIER PROTEIN Permeases CALCIUM/PROTON ANTIPORTER Fer-richrome transport proteins MACROLIDE-EFFLUX PROTEIN PUTATIVE 3-(3-HYDROXYPHENYL) PROPIONATE TRANSPORT PROTEIN PNUC PROTEIN Permeases Nucfeic Acid Amino Acid SEQI ID NO SEQ ID NO 605 606 607 608 609 610 611 612 613 614 615 616 Identification Code Cont NT Start NT Stop Function RXN02566 F RXA02561 F RXA02566 RXA00051 RXAO1 172 RXA021 28 W01 54 11823 13031 NUCLEOSIDE PERMEASE NUPG GR00732 664 5 NUCLEOSIDE PERMEASE NUPG GR00733 782 345 NUCLEOSIDE PERMEASE NUPG GROO008 5770 7173 PROLINE-SPECIFIC PERMEASE PROY GR00334 2687 4141 SULFATE PERMEASE GR00637 2906 4600 SULFATE PERMEASE 2006200795 24 Feb 2006 Nucleic Acid SEQ ID NO 617 619 621 623 625 627 629 631 633 635 637 639 641 643 645 647 64 9 651 Table 1 (continued) NT Start NT Stop Function Amino Acid SEQ ID NO 618 620 622 624 626 628 630 632 634 636 638 640 642 644 646 648 650 652 Identification Code Contig.: RXA02634 RXN02233 F RXA02233 RXN02372 F RXA02372 F RXA02377 RXA02676 RXN00432 F RXA00432 F RXA00436 RXAC0847 RXN01 382 F RXA01 382 RXA02659 RXN02933 RXN02991 RXN02992 RXN02996 RXN03126 RXN00443 RXN00444 RXN00 193 RXN01298 GR00748 6045 7655 W0068 6856 8142 GR00653 6856 8067 W0213 9311 11197 GR00688 6 560 GRO0689 3336 4526 GR00754 2697 1309 W01 12 14751 13267 GROO100 1 891 GROO101 45 569 GR00230 1829 381 W0119 8670 9761 GR00405 1067 6 GR00753 2 313 WV01 76 30042 29233 VVOD72 618 4 W0072 842 621 W0069 1980 2648 W01 12 9894 9001 W0112 21572 20769 W01 12 20785 19949 W0371 1 594 W0116 2071 1142 SULFATE PERMEASE URACIL PERMEASE URACIL PERM EASE XANTHINE PERM EASE XANTIIINE PERMEASE XANTHINE PERMEASE GLUCONATE PERMEASE NA(+)-LINKED D-ALANINE GLYCINE PERMEASE NAN+-LINKED D-ALANINE GLYCINE PERMEASE NA(+).LINKED D-ALANINE GLYCINE PERMEASE OLIGOPEPTIDE-BIN DING PROTEIN APPA PRECURSOR (permease) OLIGOPEPTIDE-BINDING PROTEIN OPPA PRECURSOR OLIGOPEPTIDE-BINDING PROTEIN OPPA PRECURSOR (permease) OLIGOPEPTIDE-BIN DING PROTEIN OPPA PRECURSOR (permease) DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DIPPC GLUTAMINE TRANSPORT SYSTEM PERMEASE PROTEIN GLNP GLUTAMINE TRANSPORT SYSTEM PERMEASE PROTEIN GLNP HIGH-AFFINITY BRANCHED-CHAIN AMINO ACID TRANSPORT PERMEASE PROTEIN LIVH TEICHOIC ACID TRANSLOCATION PERMEASE PROTEIN TAGG MOLYBOATE-BINDING PERIPLASMIC PROTEIN PRECURSOR MOLYBDENUM TRANSPORT SYSTEM PERMEASE PROTEIN MOOB POTENTIAL STARCH DEGRADATION PRODUCTS TRANSPORT SYSTEM PERMEASE PROTEIN AMYD POTENTIAL STARCH DEGRADATION PRODUCTS TRANSPORT SYSTEM PERMEASE PROTEIN AMYD 661 662 Channel Proteins Nucleic Acid SEQ ID NO 663 665 667 669 671 Amino Acid SEQ ID NO 664 666 668 670 672 Identification Code RXA01 737 RXN02348 RXA02426 RXN031 64 RXN00024 ontig GR00493 W0078 GR00707 W0277 Ol 127 NT Start NT Stop Function 2913 6027 2165 1586 64219 3971 7910 633 2455 63275 POTASSIUM CHANNEL PROTEIN KUP SYSTEM POTASSIUM UPTAKE PROTEIN PROBABLE ANTIPORTER POTASSIUM CHANNEL BETA SUBUNIT POTASSIUM CHANNEL BETA SUBUNIT Lipoprotein and Li popolysacc ha ride synthesis Nucleic Acid SEQ ID NO 673 Amino Acid Identification Code Cot.

SEQ ID NO 674 R.XN01 164 W01 17 NT Start NT Stop Function 15894 W01 17 14224 14260 13415 675 676 RXN01 168 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE (EC 2.4.1.83)1 APOLIPOPROTEIN N-ACYLTRANSFERASE (EC 2.31-) DOLICIIOL-PHOSPHATE MANNOSYLTRANSFERASE (EC 2.4.1.83)1 APOLIPOPROTEIN N-ACYLTRANSFERASE (EC 2006200795 24 Feb 2006 2 Excluded Genes GenBank TM Gene Name Gene Function Reference Accession No.

A09073 ppg Phosphoenol pyruvate carboxytase Bachmann, B. et al. "DNA fragment coding for phosphoenolpyruvat corboxylase, recombinant DNA carrying said fragment, strains carrying the recombinant DNA and method for producing L-aminino acids using said strains," Patent: EP 0358940-A 3 03/21/90 A45579, Threonine dehydratase Moeckel, B. et al. "Production of L-isoleucine by means of recombinant A45581, micro-organisms with deregulated threonine dehydratase," Patent: WO A45583, 95 19442-A 5 07/20/95 A45585 A45587 ABOO3 132 murC; ftsQ; ftsZ Kobayashi, M. et al. "Cloning, sequencing, and characterization of the ftsZ gene from coryneform bacteria," Biochem. Biophys. Res. Comm un..

(1997) ABO 15023 murC; ftsQ Wachi, M. et at. "A murC gene from Coryneform bacteria," App!. Microbiol Biotechnol, 5 1(2):223-228 (1999) ABO 18530 dtsR Kimura, E. et al. "Molecular cloning of a novel gene, dtsR, which rescues the detergent sensitivity of a mutant derived from Brevibacterium Biosci. Biotechnol Biochem., 60(10): 1565-1570 (1996) AB0 18531 dtsRI; AB020624 muri D-glutamate racemase AB023377 tkt transketolase AB024708 gltB; gltD Glutamine 2-oxoglutarate aminotransferase large and small subunits AB025424 acn aconitase AB027714 rep Replication protein AB0277 15 rep; aad Replication protein; aminoglycoside AF005242 argC dehydrogenase A F005635 gInA Glutamine synthetase AF030405 hisF AF030520 argG Argininosuccinate synthetase AF03 1518 argF Ornithine carbaniolytransferase AF036932 aroD 3-dehydroquinate dehydratase AF038548 pyc Pyruvate carboxylase 2006200795 24 Feb 2006 2 (continued) AF038651 dciAE; apt; rel Dipeptide-binding protein; adenine Wehmeier, L. et al. "The role of the Corynebacterium glutamicumn rel gene in phosphoribosyltransferase; GTP (p)ppGpp metabolism," Microbiology 144:1853-1862 (1998) pyrophosphokinase AF04 1436 argR Arginine repressor AF045998 impA Inositol monophosphate phosphatase AF048764 argH Argininosuccinate lyase AF049897 argC; argi; argB; N -acetyl[g]utam ylIphosphate reductase; argD; argF; argR; omnithine acetyltransferase; NargG; argH acetyiglutamnate kinase; acetylornithine transminase; omnithine carbamoyltransferase; arginine repressor; argininosuccinate synthase; ___________argininosuccinate lyase AF050 109 inhA Enoyl-acyl carrier protein reductase AF050 166 hisG ATP phosphoribosylItran sfe rase AF051846 hisA Phosphoribosylformimino-5-amino-1Iphosphoribosyl-4-im idazolecarboxam ide AF052652 metA Homoserine 0-acetyltransferase Park, S. et al. "Isolation and analysis of metA, a methionine biosynthetic gene encoding homoserine acetyltransferase in Corynebacteriumn glutamicum," Mo!.

8(3):286-294 (1998) AF053071 aroB Dehydroquinate synthetase AF060558 hisH Glutamine amidotransferase AF086704 hisE Phosphoribosyl-ATPpyrophosphohydrolase AF 14233 aroA 5-enolpyruvylshikimate 3-phosphate AF 16184 panD L-aspartate-alIpha-decarbaxy lase precursor Dusch, N. et al. "Expression of the Corynebacterium glutamicumn panD gene encoding L-aspartate-a lpha-d ecarbox ylase leads to pantothenate overproduction in Escherichia coli," Appi. Environ. MicrobioL., 65(4)1530- 1539 (1999) AF 124518 aroD; aroE 3-dehydroquinase; shikimate dehydrogenase AF124600 aroC; aroK; aroB; Chorismate synthase; shikimate kinase; 3pepQ dehydroquinate synthase; putative ic peptidase AF145897 inhA AF145898 2006200795 24 Feb 2006 2 (continued) AJO0 1436 ectP Transport of ectoine, glycine betaine, Peter, H. et al. "Corynebacterium glutamicum is equipped with four secondary praline carriers for compatible solutes: Identification, sequencing, and characterization of the proline/ectoine uptake system, ProP, and the ectoine/proline/glycine carrier, EctP," J. BacierioL, 180(22):6005-6012 (1998) AJO04934 dapD Tetrahydrodipicolinate succinylase Wehrmann, A. et al. "Different modes of diaminopimelate synthesis and their (incomplete') role in cell wall integrity: A study with Corynebacterium glutamicum," J.

BacterioL, 180(1 2):3 159-3165 (1998) AJO07732 ppc; secG; amt;- ocd; Phosphoenolpyruvate-carboxylase; high soxA affinity ammonium uptake protein; putative oni th ine-cyc lodecarboxy lase; sarcosinev oxidase AJO 103 19 ftsY, gln B, glnD; srp; Involved in cell division; PI protein; Jakoby, M. et al. "Nitrogen regulation in Corynebacterium glutamicum; amtP uridylyltransferase (uridylyl-removing Isolation of genes involved in biochemical characterization of corresponding enzmye); signal recognition particle; low proteins," FEMS MicrobioL, 173(2):303-310 (1999) ~~affinity ammonium uptake protein A.1132968 cat Chioramphenicol aceteyl transferase AJ224946 mqo L-malate: quinone oxidoreductase Molenaar, D. et al. "Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium AJ23250 dh NDH lehyrogeaseglutamicum," Eur. J. Biochem., 254(2):395-403 (1998) A1238703 porA Porin Lichtinger, T. et al. "Biochemical and biophysical characterization of the cell wall porin of Corynebacterium glutamicum: The channel is formed by a low molecular mass polypeptide," Biochemisiry 37(43): 15024-15032 (1998) Dl17429 Transposable element 1S3 1831 VIrts et al."lsolation and characterization of 1S3 183 1, a transposable element Corynebacterium glutamicum," Mo. Microbiol, 11 (4):739-746 (1994) D84 102 odhA 2-oxoglutarate dehydrogenase Usudla, Y. et al. "Molecular cloning of the Corynebacteriumn glutamicumn (Brevibacterium lactofermentum Al 12036) odhA gene encoding a novel type of 2-oxoglutarate dehydrogenase," Mlicrobiology, 142:3347-3354 (1996) E01 358 hdh; hk Homoserine dehydrogenase; homoserine Katsumata, R. et al. "Production of L-thereonine and L-isoleucine," Patent: JP kinase 1987232392-A 1 10/12/87 E01359 Upstream of the start codon of homoserine Katsumata, R. et al. "Production of L-thereonine and L-isoleucine," Patent: JP kinase gene 1987232392-A 2 10/12/87 E01375 __________Tryptophan operon E01376 trpL; trpE Leader peptide; anthranilate synthase Matsui, K. et al. "Tryptophan operon, peptide and protein coded thereby, utilization of tryptophan operon gene expression and production of tryptophan," Patent: JP 1987244382-A 1 10/24/87 2006200795 24 Feb 2006 Table 2 (continued) EQ01377 Promoter and operator regions of Matsui, K. et al. "Tryptophan operon, peptidle and protein coded thereby, tryptophan operon utilization of tryptoplian operon gene expression and production of tryptophan," Patent: JP 1987244382-A 1 10/24/87 E03937 Biotin-synthase Hatakeyama, K. et al. "DNA fragment containing gene capable of coding synthetase and its utilization," Patent: JP 1992278088-A 1 10/02/92 E04040 Diamino pelargonic acid aminotransferase Kohama, K. et al. "Gene coding diaminopelargonic acid aminotransferase and dlesthiobiotin synthetase and its utilization," Patent: JP 1992330284-A 1 E04041 Desthiobiotinsynthetase Kohama, K. et al. "Gene coding diaminopelargonic acid aminotransferase and dlesthiobiotin synthetase and its utilization," Patent: JP 1992330284-A 1 E04307 Flavum aspartase Kurusu, Y. et al. "Gene DNA coding aspartase and utilization thereof," Patent: 1993030977-A 1 02/09/93 E04376 Isocitric acid lyase Katsumata, R. et al. "Gene manifestation controlling DNA," Patent: JP 3 03/09/93 E04377 Isocitric acid lyase N-terminal fragment Katsumata, R! ct al. "Gene manifestation controlling DNA," Patent: JP 3 03/09/93 E04484 Prephenate dehydratase Sotouchi, N. et al. "Production of L-phenylalanine by fermnentation," Patent: JP 1993076352-A 2 03/30/93 108 Aspartokinase Fugono, N. et al. "Gene DNA coding Aspartokinase and its use," Patent: JP 1993184366-A 1 07/27/93 E051 12 Dihydro-dlipichorinate synthetase Hatakeyama, K. et al. "Gene DNA coding dlihydrodlipicolinic acid synthetase and its use," Patent: JP 1993 18437 1-A 1 07/27/93 hrgns E05776 Diaminopimelic acid dlehydrogenase Kobayashi, M. et at. "Gene DNA coding Diaminopimelic acid dehydoene its use," Patent: JP 1993284970-A 1 11/02/93 E05779 Threonine synthase Kohama, K. et al. "Gene DNA coding threonine synthase and its use," Patent: 1993284972-A 1 11/02/93 E061 10 Prephenate dehydratase Kikuchi, T. et at. "Production of L-phenylalanine by fermentation method," JP 1993344881-A 1 12/27/93 E061 11 Mutated Prephenate dlehydratase Kikuchi, T. et al. "Production of L-phenylalanine by fermentation method," Patent: JP 1993344881-A 1 12/27/93 E06146 Acetohydroxy acid synthetase lnui, M. et at. "Giene capable of coding Acetohydroxy acid synthetase and its -use," Patent: JP 1993344893-A 1 12/27/93 E06825 Aspartokinase Sugimoto, M. et al. "Mutant aspartokinase gene," patent: JP 1994062866-A 1 E06826 Mutated aspartokinase alpha subunit Sugimoto, M.eta."untsptonsegeptn:JP94026-I 2006200795 24 Feb 2006 Table 2 (continued) E06827 Mutated aspartokinase alpha subunit Sugimoto, M. et "Mutant aspartokinase gene," patent: JP 1994062866-A I E07701 secY Honno, N. et "Gene DNA participating in integration of membraneous to membrane," Patent: JP 1994 169780-A 1 06/21/94 E08 177 Aspartokinase Sato, Y. et al. "Genetic DNA capable of coding Aspartokinase released from inhibition and its utilization," Patent: JP 199426 1766-A 1 09/20/94 E08 178, Feedback inhibition-released Aspartokinase Sato, Y. et al. "Genetic DNA capable of coding Aspartokinase released from E08179, feedback inhibition and its utilization," Patent: JP 1994261766-A 1 09/20/94 E08 180, E08 181, E08 182 E08232 Acetohydroxy-acid isomeroreductase lnui, M_ et aL "Gene DNA coding acetohydroxy acid isomeroreductase," Patent: JP 1994277067-A 1 10/04/94 E08234 secE Asai, Y. et al. "Gene DNA coding for n-anslocation machinery of protein," JP 1994277073-A 1 10/04/94 E08643 FT aminotransferase and desthiobiotin Hatakeyama, K. et al. "DNA fragment having promoter function in promoter region coryneform bacterium," Patent: JP 199503 1476-A 1 02/03/95 E08646 Biotin synthetase Hatakeyama, K. et al. "DNA fragment having promoter function in coryneform bacterium," Patent: JP 199503 1476-A I 02/03/95 E08649 Aspartase Kohama, K. et al "DNA fragment having promoter function in coryneform Patent: JP 1995031l478-A 1 02/03/95 E08900 Dihydrodipicolinate reductase Madori, M. et al. "DNA fragment containing gene coding Dihydrodipicolinate reductase and utilization thereof," Patent: JIP 1995075578-A 1 03/20/95 E08901 Diaminopimelic acid decarboxylase Madori, M. et al. "DNA fragment containing gene coding Diaminopimelic acid decarboxylase and utilization thereof," Patent: JP 1995075579-A 1 03/20/95 E12594 Serine hydroxymethyltransferase Hatakeyama, K. et al. "Production of L-trypophan," Patent: JP 1997028391-A 02/04/97 E 12760, transposase Moriya, M. et al. "Amplification of gene using artificial transposon," Patent: E 12759, JP 1997070291 -A 03/18/97 E12758 E12764 Arginyl-tRNA synthetase; diaminopimelic Moriya, M. et al. "Amplification of gene using artificial transposon," Patent: cid eabxls JP 199707029 I -A 03/18/97 E12767 Dihydrodipicolinic acid synthetase Moriya, M. et "Amplification of gene using artificial transposon," Patent: JP 1997070291 -A 03/18/97 E12770 aspartokinase Moriya, M. et al. "Amplification of gene using artificial transposon," Patent: 1997070291 I-A 03/18/97 E12773 Dihydrodipicolinic acid reductase Moriya, M. et al. "Amplification of gene using artificial transposon," Patent: 1997070291I-A 03/18/97 2006200795 24 Feb 2006 Table 2 coninued) E13655 Glucose-6-phosphate dehydrogenase Hatakeyama, K. et al. "Glucose-6-phosphate dehydrogenase and DNA capable of coding the same," Patent: JP 199722466 1-A 1 09/02/97 L01508 INvA Threonine dehydratase Moeckel, B. et "Functional and structural analysis of the threonine dehydratase of Corynebacteriumn glutamicum," J Bacterial., 174:8065-8072 (1992) L07603 EC 4.2.1.15 3-deoxy-D-arabinoheptulosonate-7- Chen, C. et al."TecoigadncotesqucefCrnbaeru phosphate synthase glutamicun 3 -deoxy- D-arab in oheptulIosonate-7-phosph ate synthase gene," M~icrobiol. Left., 107:223-230 (1993) L09232 IlvB; ilvN; ilvC Acetohydroxy acid synthase large subunit; Keilhauer, C. et al. "Isoleucine synthesis in Corynebacteriumn glutamicum: Acetohydroxy acid synthase small subunit; molecular analysis of the ilvB-ilvN-ilvC operon," J BacterioL, 175(17):5595acid isomeroreductase 5603 (1993) L18874 PtsM Phosphoenolpyruvate sugar Fouet, A et al. "Bacillus subtilis sucrose-specific enzyme If of the phosphotransferase phosphotransferase system: expression in Escherichia coli and homology to enzymes If from enteric bacteria," PNAS USA, 84(24):8773-8777 (1987); Lee, J.K. et "Nucleotide sequence of the gene encoding the Corynebacteriumn glutamicum mannose enzyme 11 and analyses of the deduced protein FEMS Microbial. Lef., 119(1-2):13 37-145 (1994) L27 123 aceB Malate synthase Lee, et "Molecular characterization of aceB, a gene encoding malate synthase in Corynebacteriumn glutamicum," J Microbial. Biotechnol., (1994) L27 126 Pyruvate kinase Jetten, M. S. et "Structural and functional analysis of pyruvate kinase from Corynebacterium glutamicum," Appi. Environ. Microbial, 60(7):2501-2507 (1994) L28760 aceA Isocitrate lyase L35906 dtxr Diphtheria toxin repressor Oguiza, J.A. et "Molecular cloning, DNA sequence analysis, and characterization of the Corynebacterium diphtheriae dtxR from Brevibacteriumn J Bacterial., 1 77(2):465-467 (1995) M13774 Prephenate dehydratase Follettie, M.T. et al. "Molecular cloning and nucleotide sequence of the ___________Corynebacteriumn glutam icumn pheA gene," J Bacterial., 167:695-702 (1986) M 16175 5S rRNA Park, Y-H. et "Phylogenetic analysis of the coryneform bacteria by 56 rRNA sequences," J Bacterial, 169:1801-1806(1987) M 16663 trpE Anthranilate synthase, 5' end Sano, K. et al. "Structure and function of the trp operon control regions of Brevibacteriumn lactofermentumn, a glutam ic-acid-producing bacterium," Gene, -200 (1987) M 16664 trpA Tryptophan synthase, 3'end Sn, K. et "Structure and function of the trp operon control regions of Brevibacteriumn lactofermentum, a glutam ic-acid-producing bacterium," Gene, (1987) 2006200795 24 Feb 2006 Table 2 (continued) M25819 Phosphoenolpyruvate carboxylase O'Regan, M. et al. "Cloning and nucleotide sequence of the Phosphoenolpyruvate carboxylase-coding gene of Corynebacterium glutamicum ATCC13032," Gene, 77(2):237-251 (1989) M85106 23S rRNA gene insertion sequence Roller, C. et al. "Gram-positive bacteria with a high DNA G+C content are characterized by a common insertion within their 23S rRNA genes," J. Gen.

Microbiol., 138:1167-1175 (1992) M85107, 23S rRNA gene insertion sequence Roller, C. et al. "Gram-positive bacteria with a high DNA G+C content are M85108 characterized by a common insertion within their 23S rRNA genes," J. Gen.

Microbiol., 138:1167-1175 (1992) M89931 aecD; brnQ; yhbw Beta C-S lyase; branched-chain amino acid Rossol, I. et al. "The Corynebacterium glutamicum aecD gene encodes a C-S uptake carrier; hypothetical protein yhbw lyase with alpha, beta-elimination activity that degrades aminoethylcysteine," J. Bacteriol., 174(9):2968-2977 (1992); Tauch, A. et al. "Isoleucine uptake in Corynebacterium glutamicum ATCC 13032 is directed by the brQ gene product," Arch. Microbiol., 169(4):303-312 (1998) S59299 trp Leader gene (promoter) Herry, D.M. et al. "Cloning of the trp gene cluster from a tryptophanhyperproducing strain of Corynebacterium glutamicum: identification of a mutation in the trp leader sequence," Appl. Environ. Microbiol., 59(3):791-799 (1993) U11545 trpD Anthranilate phosphoribosyltransferase O'Gara, J.P. and Dunican, L.K. (1994) Complete nucleotide sequence of the Corynebacterium glutamicum ATCC 21850 tpD gene." Thesis, Microbiology Department, University College Galway, Ireland.

U13922 cglIM; cgllR; clglIR Putative type II 5-cytosoine Schafer, A. et al. "Cloning and characterization of a DNA region encoding a methyltransferase; putative type II stress-sensitive restriction system from Corynebacterium glutamicum ATCC restriction endonuclease; putative type I or 13032 and analysis of its role in intergeneric conjugation with Escherichia type III restriction endonuclease coli," J. Bacteriol., 176(23):7309-7319 (1994); Schafer, A. et al. "The Corynebacterium glutamicum cgllM gene encoding a 5-cytosine in an McrBCdeficient Escherichia coli strain," Gene, 203(2):95-101 (1997) U 14965 recA U31224 ppx Ankri, S. et al. "Mutations in the Corynebacterium glutamicumproline biosynthetic pathway: A natural bypass of the proA step," J. Bacteriol., 178(15):4412-4419 (1996) U31225 proC L-proline: NADP+ 5-oxidoreductase Ankri, S. et al. "Mutations in the Corynebacterium glutamicumproline biosynthetic pathway: A natural bypass of the proA step," J. Bacteriol., 178(15):4412-4419 (1996) U31230 obg; proB; unkdh ?;gamma glutamyl kinase;similar to D- Ankri, S. et al. "Mutations in the Corynebacterium glutamicumproline isomer specific 2-hydroxyacid biosynthetic pathway: A natural bypass of the proA step," J. Bacteriol., dehydrogenases 178(15):4412-4419 (1996) 2006200795 24 Feb 2006 2 (continued) U31281 bioB Biotin synthase Serebriiskii, "Two new members of the bio B superfamily: Cloning, sequencing and expression of bio B genes of Methylobacillus flagellatum and Corynebacterium glutamicum," Gene, 175:15-22 (1996) U35023 thtR; accBC Thiosulfate sulfurtransferase; acyl CoA Jager, W. et al. "A Corynebacterium glutamicum gene encoding a two-domain carboxylase protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins," Microbiol., 166(2);76-82 (1996) U43535 cmr Multidrug resistance protein Jager, W. et al. "A Corynebacterium glutamicum gene conferring multidrug resistance in the heterologous host Escherichia coli," J Bacteriol., 179(7):2449-245 1 (1997) U43536 clpB Heat shock ATP-binding protein U53587 aphA-3 3'5' -aminoglycoside phosphotransferase U89648 Corynebacterium glutamicum unidentified sequence involved in histidine biosynthesis, partial sequence X04960 trpA; trpB; trpC; trpD; Tryptophan operon Matsui, K. et al. "Complete nucleotide and deduced amino acid sequences of trpE; trpG; trpL the Brevibacterium lactofermentum tryptophan operon," Nucleic Acids Res., 14(24):101 13-10114 (1986) X07563 lys A DAP decarboxylase (meso-diaminopimelate Yeh, P. et al. "Nucleic sequence of the lysA gene of Corynebacterium decarboxylase, EC 4.1.1.20) glutanicum and possible mechanisms for modulation of its expression," Mot.

Gen. Genet., 212(l):112-119 (1988) X14234 EC 4.1.1.31 Phosphoenolpyruvate carboxylase Eikmanns, B.J. et al. "The Phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicumn: Molecular cloning, nucleotide sequence, and expression," Mot. Gen. Genet., 218(2):330-339 (1989); Lepiniec, L. et al.

"Sorghum Phosphoenolpyruvate carboxylase gene family: structure, function and molecular evolution," Plant. Mo!. Biol., 21 (3):487-502 (1993) X17313 fda Fructose-bi sphosph ate aldolase Von der Osten, C.H. et al. "Molecular cloning, nucleotide sequence and finestructural analysis of the Corynebacterium glutamicum fda gene: structural comparison of C. glutamicum fructose-I1, 6-biphosphate aldolase to class I and class 11 aldolases," Mo!. Microbiol., X53993 dapA L-2, 3-dihydrodipicolinate synthetase (EC Bonnassie, S. et al. "Nucleic sequence of the dapA gene from Corynebacterium glutamicum," Nucleic Acids Res., 18( 1 ):642 I (1990) X54223 AtiB-related site Cianciotto, N. et al. "DNA sequence homology between att B-related sites of Corynebacterium diphtheriae, Corynebacterium ulcerans, Corynebacterium glutamicumn and the attP site of lanibdacorynephage," FEMS. Microbiol, et., 6:29-302 (1990) X54740 argS; lysA Arginyl-tRNA synthetase; Diaminopimelate Marcel, T. et al. "Nucleotide sequence and organization of the upstream region decarboxylase of the Corynebacterium glutamicum lysA gene," Mo. Microbio., 4(1 l):1819- (1990) 2006200795 24 Feb 2006 Table 2 (continued) X55994 trpL; trpE Putative leader peptide; anthranilate Heery, D.M. et al. "Nucleotide sequence of the Corynebacterium glutamicum synthase componient I trpE gene," Nucleic Acids Res., 18(23):7138 (1990) X56037 thrC Threonine synthase Han, K.S. et al. "The molecular structure of the Corynebacterium glutamicum threonine synthase gene," at. Microbiol., 4(10):1693-1702 (1990) X56075 attB-related site Attachment site Cianciotto, N. et al. "DNA sequence homology between att B3-related sites of_ Corynebacteriumn diphtheriae, Corynebacterium ulcerans, Corynebacteriumn glutamicum and the attP site of lambdacorynephage," Fk.MS. Microbiol, Leu., 66:299-302 (1990) X57226 lysC-alpha; lysC-beta; Aspartokinase-alpha subunit; Kalinowski, J. et al. "Genetic and biochemical analysis of the Aspartokinase asd Aspartokinase-beta subunit; aspartate beta from Corynebacterium glutamicum," Mat. Microbial, 5(5):1 197-1204 (1991); semnialdehyde dehydrogenase Kalinowski, J. et al. "Aspartokinase genes lysC alpha and lysC beta overlap and are adjacent to the aspertate beta-semialdehyde dehydrogenase gene asd in glutamicum," Mat. Gen. Genet., 224(3):3 17-324 (1990) X59403 gap;pgk; tpi Glyceraldehyde-3-phosphate; Eikmanns, B.J. "Identification, sequence analysis, and expression of a phosphoglycerate kinase; triosephosphate Corynebacterium glutamicum gene cluster encoding the three glycolytic isomerase enzymes glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and triosephosphate isomeras," J. Bacterial, 174(19):6076-6086 (1992) X59404 gdh Glutamate dehydrogenase Bormann, E.R. et al. "Molecular analysis of the Corynebacterium glutamicum gdh gene encoding glutamate dehydrogenase," Ma!. Microbial., 6(3):3 17-326 (1992) X60312 lysi L-lysine permease Seep-Feldhaus, A.H. et al. "Molecular analysis of the Corynebacterium glutamicum lysi gene involved in lysine uptake," Mat. Microbial, 5(12):2995- 3005 (1991) X66078 cop I Psi protein Joliff, G. et al. "Cloning and nucleotide sequence of the cspl gene encoding PSI, one of the two major secreted proteins of Corynebacterium glutamicum: The deduced N-terminal region of PS I is similar to the Mycobacterium antigen complex," Mo!. MicrobiaL, 6(16):2349-2362 (1992) X661 12 glt Citrate synthase Eikmanns, B.J. et al. "Cloning sequence, expression and transcriptional analysis of the Corynebacterium glutamicum gltA gene encoding citrate MicrobiaL, 140:1817-1828 (1994) X67737 dapB Dihydrodipicolinate reductase X69 103 csp2 Surface layer protein PS2 Peyret, J.L. et al. "Characterization of the cspB gene encoding PS2, an ordered surface-layer protein in Corynebacterium glutamicum," at6. Microbial, 9(l):97-109 (1993) X69 104 153 related insertion element Bonamy, C. et al. "Identification of IS 1206, a Corynebacterium glutamicum IS3-related insertion sequence and phylogenetic analysis," Mat. MicrobiaL, 14(3):571-581 (1994) 2006200795 24 Feb 2006 Table 2 (continued) X70959 leuA Isopropylmalate synthase Patek, M. et al. "Leucine synthesis in Corynebacterium glutamicum: enzyme activities, structure of leuA, and effect of leuA inactivation on lysine synthesis," Appi. Environ. Microbial., 60(l): 133-140 (1994) X71489 icd Isocitrate dehydrogenase (NADP+) Eikmanns, B.J. et al. "Cloning sequence analysis, expression, and inactivation of the Corynebacteriumn glutamicumn icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme," J. Bacterial, 177(3):774-782 (1995) X72855 GDHA Glutamnate dehydrogenase (NADP+) X75083, mtrA 5-methyltryptophan resistance Heery, D.M. et al. "A sequence from a tryptophan-hyperproducing strain of X70584 Corynebacteriumn glutamicum encoding resistance to 5-m ethyl tryptophan," Biophys. Res. Commun., 201(3): t255-1262 (1994) X75085 recA Fitzpatrick, R. et al. "Construction and characterization of recA mutant strains of Corynebacterium glutam icum and Brevibacterium lactofermentum," AppI.

MicrobiaL Biatechnal., 42(4):575-580 (1994) X75504 aceA; thiX Partial Isocitrate lyase; Reinscheid, D.J. et al. "Characterization of the isocitrate lyase gene from Corynebacterium glutamicumn and biochemical analysis of the enzyme," J.

BacteriaL, 176(1 2):3474-3483 (1994) X76875 ATPase beta-subunit Luwig, W. et al. "Phylogenetic relationships of bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit Anfanie Van Leeuwenhoek, 64:285-305 (1993) X77034 tuf Elongation factor Tu Ludwig, W. et al. "Phylogenetic relationships of bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit AnIanie Van Leeuweniiaek 64:285-305 (1993) X77384 recA Biliman-Jacobe, H. "Nucleotide sequence of a recA gene from Corynebacterium glutamicum," DNVA Seq., 4(6):403-404 (1994) X78491 aceB Malate synthase Reinscheid, D.J. et al. "Malate synthase from Corynebacteriumn glutamicumn pta-ack operon encoding phosphotransacetylase: sequence analysis," 140:3099-3108 (1994) X80629 16S rDNA 16S ribosomal RNA Rainey, F.A. et al. "Phylogenetic analysis of the genera Rhodococcus and Norcardia and evidence for the evolutionary origin of the genus Norcardia from within the radiation of Rhodococcus species," Mlicrobial., 14 1:523-528 (1995) X81 191 gluA; gluB; gluC; Glutamnate uptake system' Kronemeyer, W. et al. "Structure of the gluABCD cluster encoding the gluD glutamate uptake system of Corynebacteriumn glutamicum," J Bacterial, 177(5):1 152-1158 (1995) X81379 dapE Succinyldiaminopimelate desuccinylase Wehrmann, A. et al. "Analysis of different DNA fragments of Corynebacteriumn glutamnicumn complementing dapE of Escherichia coli," 40:3349-56 (1994) 2006200795 24 Feb 2006 Tabe 2coninued) X82061 16S rDNA 16S ribosomal RNA Ruimy, R. et al. "Phylogeny of the genus Corynebacteriumn deduced from analyses of small-subunit ribosomal DNA sequences," Int. J. Syst. Bacterial., 45(4):740-746 (1995) X82928 asd; 1ysC Aspartate-semialdehyde dehydrogenase; Serebrijski, 1. et al. "Multicopy suppression by asd gene and osmotic stressdependent complementation by heterologous proA in proA mutants," J.

Bacleriol, 1 77(24):7255-7260 (1995) X82929 proA Gamma-glutamyl phosphate reductase Serebrijski, 1. et al. 'Multicopy suppression by asd gene and osmotic stressdependent complementation by heterologous proA in proA mutants," J.

Bacterial, 1 77(24):7255-7260 (1995) X84257 16S rDNA 16S ribosomal RNA Pascual, C. et al. "Phylogenetic analysis of the genus Corynebacterium based on 16S rR.NA gene sequences," Int. J. Syst. Bacleriol., 45(4):724-728 (1995) X85965 aroP; dapE Aromatic amino acid permease; Wehrmann et al. "Functional analysis of sequences adjacent to dapE of C.

glutamicum proline reveals the presence of aroP, which encodes the aromatic acid transporter," J Bacterial., 177(20):5991-5993 (1995) X86 157 argB; argC; argD; Acetylglutamate kinase; N-acetyl-gamma- Sakanyan, V. et al. "Genes and enzymes of the acetyl cycle of arginine argF; argJ glutamyl-phosphate reductase; biosynthesis in Corynebacterium glutamicum: enzyme evolution in the early acetylomithine aminotransferase; orn ithine steps of the arginine pathway," Microbiology, 142:99-108 (1996) carbamoyltransferase; glutamate N- ______________acetyltransferase X89084 pta; ackA Phosphate acetylItrans ferase; acetate kinase Reinscheid, D.J. et al. "Cloning, sequence analysis, expression and inactivation of the Corynebacterium glutamicumn pta-ack operon encoding and acetate kinase," Microbiology, 145:503-5 13 (1999) X89850 attB Attachment site Le Marrec, C. et al. "Genetic characterization of site-specific integration functions of phi AAU2 infecting "Arthrobacter aureus C70,"J Bacterial., 178(7): 1996-2004 (1996) X90356 Promoter fragment FlI Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, (1996) X90357 Promoter fragment F2 Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, (1996) X90358 Promoter fragment F 10 Patek, M. et al. "Promoters from Corynebacterium glutaxnicumn: cloning, molecular analysis and search for a consensus motif," Microbiology, 142:1297-1309 (1996) X90359 Promoter fragment F13 Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142:1297-1309 (1996) 2006200795 24 Feb 2006 Table 2 (continued) X90360 Promoter fragment F22 Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142:1297-1309 (1996) X90361 Promoter fragment F34 Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142:1297-1309 (1996) X90362 Promoter fragment F37 Patek, M. et al. "Promoters from C. glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142:1297-1309 (1996) X90363 Promoter fragment F45 Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142:1297-1309 (1996) X90364 Promoter fragment F64 Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142:1297-1309 (1996) X90365 Promoter fragment F75 Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142:1297-1309 (1996) X90366 Promoter fragment PFI01 Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142:1297-1309 (1996) X90367 Promoter fragment PF104 Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142:1297-1309 (1996) X90368 Promoter fragment PF109 Patek, M. et al. "Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif," Microbiology, 142:1297-1309 (1996) X93513 amt Ammonium transport system Siewe, R.M. et al. "Functional and genetic characterization of the (methyl) ammonium uptake carrier of Corynebacterium glutamicum," J Biol. Chem., 271(10):5398-5403 (1996) X93514 betP Glycine betaine transport system Peter, H. et al. "Isolation, characterization, and expression of the .Corynebacterium glutamicum betP gene, encoding the transport system for the compatible solute glycine betaine," J. Bacteriol., 178(17):5229-5234 (1996) X95649 orf4 Patek, M. et al. "Identification and transcriptional analysis of the dapB-ORF2dapA-ORF4 operon of Corynebacterium glutamicum, encoding two enzymes involved in L-lysine synthesis," Biolechnol. Lett., 19:1113-1117 (1997) X96471 lysE; lysG Lysine exporter protein; Lysine export Vrljic, M. et al. "A new type of transporter with a new type of cellular regulator protein function: L-lysine export from Corynebacterium glutamicum," Mol.

Microbiol., 22(5):815-826 (1996) 2006200795 24 Feb 2006 Table 2 (continued) X96580 panB; panC; xylB 3-methyl-2-oxobutanoate Sahm, H. et al "D-pantothenate synthesis in Corynebacterium glutamicumn and hydroxymethyltransferase; pantoate-beta- use of panBC and genes encoding L-valine synthesis for D-pantothenate alanine ligase; xylulokinase overproduction," App!. Environ. Microbiol., 65(5):1973-1979 (1999) X96962 Insertion sequence IS 1207 and transposase X99289 Elongation factor P Ramos, A. et al. "Cloning, sequencing and expression of the gene encoding elongation factor P in the amino-acid producer Brevibacterium lactofermentum (Corynebacterium glutamicum ATCC 13869)," Gene 198:217-222 (1997) Y00140 thrB Homoserine kinase Mateos, L.M. et al. "Nucleotide sequence of the homoserine kinase (thrB) gene of the Brevibacterium lactofermentum," Nucleic Acids Res., 15(9):3922 (1987) Y00151 ddh Meso-diaminopimelate D-dehydrogenase Ishino, S. et al. "Nucleotide sequence of the meso-diaminopimelate D- (EC 1.4.1.16) dehydrogenase gene from Corynebacteriumn glutamicum," Nucleic Acids Res., 15(9):3917 (1987) Y00476 thrA Homoserine dehydrogenase Mateos, L.M. et al. "Nucleotide sequence of the homoserine dehydrogenase (thrA) gene of the Brevibacteriumn lactofermentum," Nucleic Acids Res., 15(24):10598 (1987) Y00546 hom; thrB Homoserine dehydrogenase; homoserine Peoples, O.P. et al. "Nucleotide sequence and fine structural analysis of the kinase Corynebacterium glutamicum hom-thrB operon," Mo!. Microbial., 2(l):63-72 (1988) Y08964 murC; ftsQfdivD; ftsZ UPD-N-acetylmuramate-alanine ligase; Honrubia, M.P. et al. "Identification, characterization, and chromosomal division initiation protein or cell division organization of the ftsZ gene from Brevibacterium lactofermentum," Mo!. Gen.

protein;, cell division protein Genet., 259(l):97-104 (1998) Y09163 putP High affinity proline transport system Peter, H. et al. "Isolation of the putP gene of Corynebacteriumn glutamicumproline and characterization of a low-affinity uptake system for solutes," Arch. Microbial., 168(2): 143-151 (1997) Y09548 pyc Pyruvate carboxylase Peters-Wendisch, P.G. et al. "Pyruvate carboxylase from Corynebacteriumn glutamicum: characterization, expression and inactivation of the pyc gene," 144:915-927 (1998) Y09578 leuB 3-isopropylmalate dehydrogenase Patek, M. et al. "Analysis of the leuB gene from Corynebacteriumn App!. Microbial. Biatechnol., 50(l):42-47 (1998) Y 12472 Attachment site bacteriophage Phi- 16 Moreau, S. et al. "Site-specific integration of corynephage Phi-16: The of an integration vector," Microbial., 145:539-548 (1999) Y 12537 proP Proline/ectoine uptake system protein Peter, H. et al. "Corynebacterium glutamicum is equipped with four secondary carriers for compatible solutes: Identification, sequencing, and characterization of the proline/ectoine uptake system, ProP, and the ectoine/prolinefglycine carrier, EctP," J. Bacterial., 180(22):6005-6012 (1998) 2006200795 24 Feb 2006 Table 2 (continued) Yl13221 ginA Glutarnine synthetase I lakoby, M. et al. "Isolation of Corynebacterium glutamicum gInA gene glutamine synthetase FEMS MicrobioL Lett., 154(1 1-88 (1997) Y 16642 lpd Dihydrol ipoamide dehydrogenase Y 18059 Attachment site Corynephage 304L Moreau, S. et al. "Analysis of the integration functions of φ304 L: An module among corynephages," Virology, 255(1): 150-159 (1999) Z21501 argS; lysA Arginyl-tRNA synthetase; diaminopimelate Oguiza, J.A. et al. "A grene encoding arginyl-tRNA synthetase is located in thedecarboxylase (partial) upstream region of the lysA gene in Brevibacterium lactofermentum: Regulation of argS-lysA cluster expression by arginine," J.

I175(22):73 56-7362 (1993) Z21502 dapA; dapB Dihydrodipicolinate synthase; Pisabarro, A. et al. "A cluster of three genes (dapA, orf2, and dapB) of dihydrodipicolinate reductase Brevibacteriumn lactofermentumn encodes dihydrodipicolinate reductase, and a third polypeptide of unknown function," I BacterioL, 175(9):2743-2749 (1993) Z29563 thrC Threonine synthase Malumbres, M. et al. "Analysis and expression of the thrC gene of the encoded synthase," Appi. Environ. MicrobioL., 60(7)2209-22 19 (1994) Z46753 16S rDNA Gene for 16S ribosomal RNA Z49822 sigA SigA sigma factor Oguiza, J.A. et al "Multiple sigma factor genes in Brevibacterium lactofernientum: Characterization of sigA and sigB," J. BacterioL, 1 78(2):550- (1996) Z49823 galE; dtxR Catalytic activity UDP-galactose 4- Oguiza, J.A. et al "The galE gene encoding the UDP-galactose 4-epimerase of epimerase; diphtheria toxin regulatory Brevibacterium lactoferrnentum is coupled transcriptionally to the dmdR protein gene," Gene, 177:103-107 (1996) Z49824 orf I; sigB SigB sigma factor Oguiza, J.A. et al "Multiple sigma factor genes in Brevibacterium lactofermentum: Characterization of sigA and sigB," J1 BaclerioL, 178(2):550- (1996) Z66534 Transposase Correia, A. et al. "Cloning and characterization of an IS-like element present in the genome of Brevibacterium lactofermentum ATCC 13869," Gene, (1996) A sequence for this gene was published in the indicated reference. However, the sequence obtained by the inventors of the present application is significantly longer than the published version. It is believed that the published version relied on an incorrect start codon, and thus represents only a fragment of the actual coding region.

-81 TABLE 3: Corynebacterium and Brevibacterium Strains Which May be Used in the Practice of the Invention '44 1.7 al ,nnt:l- g1 Ty I-Ds4Z 21054-RIT E~ICL Brevibacterium lammoniagenes Brevibacterium animoniagenes 19350 Brevibacterium ammoniagenes 19351 Brevibacterium ammoniagenes 19352 Brevibacterium ammoniagenes 19353 Brevibacterium ammoniagenes 19354 Brevibacterium ammoniagenes 19355 Brevibacterium ammoniagenes 19356 Brevibacterium ammoniagenes 21055 Brevibacterium ammoniagenes 21077 Brevibacterium ammoniagenes 21553 Brevibacterium ammoniagenes 21]580 Brevibacterium ammoniagenes 39101 Brevibacterium butanicum 21196 Brevibacterium divaricatum 21792 P928 Brevibacterium flavum 21474 Brevibacterium flavum 21129 Brevibacterium flavum 21518 Brevibacterium flavum B 11474 Brevibacterium flavum BI 1472- Brevibacterium flavum 21127 Brevibacterium flavum 21128 Brevibacterium flavum 21427 Brevibacterium flavum 21475 Brevibacterium flavum 21517 Brevibacterium flavum 21528 Brevibacterium flavum 21529 Brevibacterium flavum Bi 11477 Brevibacterium flavum B! 11478 Brevibacterium flavum 21127 Brevibacterium flavum B 11474 Brevibacterium healii 15527-- Brevibacterium ketoglutamicum 21004 Brevibacterium ketoglutanucum 21089 Brevibacterium ketosoreductum 21914 Brevibacterium lactofermentum Brevibacterium lactofermentum 74 Brevibacterium lactofermentum 77 Brevibacterium lactofermentum 21798 Brevibacterium lactofermentum 21799 Brevibacterium lactofermentum 21800 Brevibacterium lactofermentum 21801 Brevibacterium lactofermentum B1 1470 Brevibacterium lactofermentum Bi 11471 82 Brevibacterium lactofermentumn 21086 Brevibacterium lactofermentumn 21420 Brevibacterium lactofermentum 21086 Brevibacteriun, lactofermentumn 31269 Brevibacterium linens 9174 Brevibacterium linens 19391 Brevibacterium linens 8377 Brevibacterium paraffinolyticum 11160 Brevibacterium Spec. ___717.73 Brevibacterium Spec. ___717.73 Brevibacterium Spec. 14604 Brevibacterium Spec. 21860 Brevibacterium Spec. 21864 Brevibacterium Spec. 21865 Brevibacterium spec. 21866 Brevibacterium Spec. 19240 Goryne bacterium acetoacidophilumn 21476 Corynebacterium acetoacidophilumn 13870 Corynebacterium acetoglutarnicumn BI 1473 Corynebacterium acetoglutamnicum B 11475 Corynebacterium acetoglutamnicumn 15806 Corynebacterium acetoglutamnicumn 21491 Corynebacterium acetoglutamnicumn 31270 Corynebacterium acetophilum B3671 Corynebacterium amnmoniagenes 6872 2399 Corynebacterium ammoniagenes 15511 Corynebacterium fujiokense 21496 Corynebacterium glutamnicumn 14067 Corynebacterium glutamnicumn 39137 Corynebacterium glutamnicumn 21254 Corynebacterium glutamnicumn 21255 Corynebacterium glutamnicumn 31830 Corynebacterium glutamnicumn 13032 Corynebacterium glutamnicumn 14305 Corynebacterium glutamnicumn 15455 Corynebacterium glutamicum 13058 Corynebacterium glutamnicumn 13059 Corynebacterium glutamnicumn 13060 Corynebacterium glutamnicumn -19 Corynebacterium glutamnicurn 21513 Corynebacterium glutamnicumn 21526 Corynebacterium glutanicumn 21543 Corynebacterium glutamnicumn 13287 Corynebacterium glutarnicumn 21851 Corynebacterium glutarnicumn 21253 Corynebacterium glutamicum 21514 Corynebacterium glutamnicumn 21516 Corynebacterium glutamnicumn 21299 83 ,G nu W ies': T C EiM~~R 3C C[B CS~ CU DStMZ Corynebacterium glutamicum 21300 Corynebacterium glutamicum 39684 Carynebacterium glutamicum 21488 Corynebacterium glutamicum 21649 Corynebacterium glutamicum 21650 Corynebacterium glutamicum 19223 Corynebacterium glutamicum 13869 Corynebacterium glutamicum 21157 Corynebacterium glutamicum 21158 Corynebacterium glutamicum 21159 Corynebacterium glutamicum 21355 Corynebacterium glutamicum 31808 Corynebacterium glutamicum 21674 Corynebacterium glutamicum 21562 Corynebacterium glutamicum 21563 Corynebacterium glutamicum 21564 Carynebacterium glutamicum 21565 Corynebacterium glutamicum 21566 Corynebacterium glutamicum 21567 Corynebacterium glutamicum 21568 Corynebacterium glutamicum 21569 Corynebacterium glutamicum 21570 Corynebacterium glutamicum 21571 Corynebacteriurn giutamicum 21572 Corynebacterium glutamicum 21573 Corynebacterium glutamicum 21579 Corynebacterium glutamicum 19049 Corynebacterium glutamicum 19050 Corynebacterium glutamicum 19051 Corynebacterium glutamicum 19052 Corynebacterium glutamicum 19053 Corynebacterium glutamicum 19054 Corynebacterium glutamicum 19055 Corynebacterium glutamicum 19056 Corynebacterium glutamicum 19057 Corynebacterium glutamicum 19058 Corynebacterium glutamicum 19059 Corynebacterium glutamicum 19060 Cforyn ebacterium glutamicum 19185 Corynebacterium glutamicum 13286 Corynebacterium glutamicum 21515 Corynebacterium glutamicum 21527 Corynebacterium glutamicum 21544 Corynebacterium glutamicum 21492 Corynebacterium glutamicum B81 83 Corynebacterium glutamicum B8182 Corynebacterium glutamicum B 12416 Corynebacterium glutainicum _____B12417 84 ]Ie- TC FFARM CNRRL CEC NCIM BJ CC~Z Corynebacterium glutamnicumn B12418 Corynebacterium glutamnicum B 11476 Corynebacterium glutamicum 21608 Corynebacterium lilium P973 Corynebacterium nitrilophilus 21419 ____11594 Corynebacterium spec. _____P4445 Corynebacterium spec. P4446 Corynebacterium spec. 31088 Corynebacterium spec. 31089 Corynebacterium spec. 31090 Corynebacterium spec. 3 1090 Corynebacterium spec. 31090 Corynebacterium spec. 15954 ____20145 Corynebacterium spec. 21857 Coryne bacterium spec. 21862 Corynebacterium spec. 21863 ATCC: American Type Culture Collection, Rockville, MD, USA FERM: Fermentation Research Institute, Chiba, Japan NRRL: ARS Culture Collection, Northern Regional Research Laboratory, Peoria, IL, USA CECT: Coleccion Espanola de Cultivos Tipo, Valencia, Spain NCIMB: National Collection of Industrial and Marine Bacteria Ltd., Aberdeen, UK CBS: Centraalbureau voor Schimmelcultures, Baamn, NL NCTC: National Collection of Type Cultures, London, UK DSMZ: Deutsche Sammiung von Mikroorganismen und Zelikulturen, Braunschweig, Germany For reference see Sugawara, H. et (1993) World directory of collections of cultures of microorganisms: Bacteria, fungi and yeasts (4h~ edn), World federation for culture collections world data center on microorganisms, Saimata, Japen.

2006200795 24 Feb 2006 ID N length Genbank Hit

INT)

1527 GB-HTG3:AC009685 GB-HTG3:AC00g685 GBHTG7:AC0095i1 rxaOOO9l 876 GBBA1:D50453 GBBA1:SC1 GB -BA1 :ECOUW93 rxa00092 789 GBBA1:SCH35 GB3-HTG3:ACO1 1498 0 GBHTG3:AC01 1498 0 rxa00104 879 GBBA1:MTCY27O GBPL2:T24M8 GBBA1:MTCY27O rxaOOl 13 5745 GBBAl MAFASGEN GBBA1:BAFASAA GB-BA1 :MTCY1 59 rxa00164 1812 GBlITG2:HSJI153D9 GBHTG2:HSJ1153D9 GB-HTG2:HSJ1 15309 rxaO0l8l 1695 GB-BA1:CGPUTP GBBA2:U32814 GB BA1 :CGPUTP Table 4: Alignment Results Length Accession Name of Genbank Hit 210031 210031 271898 146191 40745 338534 45396 312343 312343 37586 68251 37586 10520 10549 33818 118360 118360 118360 3791 10393 3791 AC009685 AC009685 AC00951 1 050453 AL109848 U14003 AL078610 AC01 1498 AC01 1498 Z95388 AF077409 Z95388 X87822 X64795 Z83863 AL1 09806 AL109806 ALl109806 Y09163 U32814 Y09163 Homo sapiens chromosome 15 clone 91_E13 map 15, "SEQUENCING IN PROGRESS 27 unordered pieces.

Homo sapiens chromosome 15 clone 91_E_1 3 map 15, SEQUENCING IN PROGRESS 27 unordered pieces.

Homo sapiens clone RP1 1-860B13, **SEQUENCING IN PROGRESS 59 unordered pieces.

Bacillus subtilis DNA for 25-36 degree region containing the amyE-srfA region, complete cds.

Streptomyces coelicolor cosniid 151.

Escherichia coli K-12 chromosomal region from 92.8 to 00.1 minutes.

Streptomyces coelicolor cosmid H135.

Homo sapiens chromosome 19 clone CIT978SKB_501-17, SEQUENCING IN PROGRESS 190 unordered pieces.

Homo sapiens chromosome 19 clone C17978SKB_501-17, SEQUENCING IN PROGRESS 190 unordered pieces.

Mycobacteriumn tuberculosis H37Rv complete genome; segment 96/162.

Arabidopsis thaliana SAC T24M8.

Mycobacterium tuberculosis H37Rv complete genome; segment 98/162.

Bammoniagenes FAS gene.

B.ammoniagenes FAS gene.

Mycobacterium tuberculosis H37Rv complete genome; segment 111/162.

Homo sapiens chromosome 20 clone RP5-1153D9, SEQUENCING IN PROGRESS in unordered pieces.

Homo sapiens chromosome 20 clone RP5-1153D9, SEQUENCING IN PROGRESS in unordered pieces.

Homo sapiens chromosome 20 clone RP5-1153D9, SEQUENCING IN PROGRESS in unordered pieces.

C.glutamicumn putP gene.

Haemnophilus influenzae Rd section 129 of 163 of the complete genomne.

C.glutamicumn putP gene.

Source of Genbank Hit Homo sapiens Homo sapiens Homo sapiens Bacillus subtilis Streptomyces coelicolor A3(2) Escherichia coi Streptomyces coelicolor Homo sapiens Homo sapiens Mycobacteriumn tuberculosis Arabidopsis thaliana Mycobacteriumn tuberculosis Corynebacterium ammoniagenes Corynebacterium ammoniagenes Mycobacteriumn tuberculosis Homo sapiens Homo sapiens Homo sapiens Corynebacteriumn glutamicumn Haemophilus influenzae Rd Corynebacterium glutamicum Homo sapiens 34,247 34,247 35,033 54,452 36,806 38,642 49.934 37.117 37,117 36,732 37,150 42,874 68,381 57,259 39,870 35,714 35,714 35,334 100,000 36,347 37,454 37.315 29-Sep-99 29-Sep-99 09-DEC-1999 10-Feb-99 1 6-Aug-99 17-Apr-96 4-Jun-99 1 3-Dec-99 13-Dec-99 10-Feb-99 3-Aug-98 1 0-Feb-99 03-OCT-i1996 14-OCT-i 997 17-Jun-98 03-DEC-i1999 03-DEC-i1999 03-DEC-i1999 8-Sep-97 29-MAY-i 998 8-Sep-97 5-Nov-98 homology Date of (GAP) Deposlt rxaOOi86 870 GBPR3AC004843 136655 AC004843 Homo sapiens PAC clone D3.10121712 from 7p12-p14. complete sequence.

2006200795 24 Feb 2006 GBHTG2:HS745114 GB-HTG2:HS745114 GBGSS1O:AQ184082 GBGSS1:CNSOO8ZZ 133309 133309 506 1101 AL033532 AL033532 AQ1 84082 AL052951 rxaOO187 474 GBGSS1O:AQ184082 506 AQ184082 rxaOO201 292 GBPR3:HSJ824F16 139330 AL050325 GBBA1:RCSECA 2724 X89411 GBEST34:AV122904 242 AV122904 rxa00228 714 GBEST1 5AA486042 515 AA486042 GB-EST15:A486042 515 AA486042 Table 4 (continued) Homo sapiens chromosome 1 clone RP4-745114 map q23.1-24.3, Homo sapiens SEQUENCING IN PROGRESS in unordered pieces.

Homo sapiens chromosome 1 clone RP4-745114 map q23.1 -24.3, Homo sapiens SEQUENCING IN PROGRESS in unordered pieces.

HS)3216_Al _G08_17 CIT Approved Human Genomic Sperm Library D Homo Homo sapiens sapiens genomic clone Plate=3216 CoI=1 5 Row=M, genomic survey sequence.

Drosophila melanogaster genome survey sequence T7 end of BAC Drosophila melanogaster BACRI1-O1 of RPCI-98 library from Drosophila melanogaster (fruit fly), genomic survey sequence.

HS_73216_AlG08_T7 CIT Approved Human Genomic Sperm Library 0 Homo Homo sapiens sapiens genomic clone Plate=3216 Coll15 Row=M, genomic survey sequence.

Human DNA sequence from done 8241716 on chromosome 20, complete Homo sapiens sequence.

R.capsulatus DNA for secA gene. Rhodlobacter capsulatus AV122904 Mus musculus C57BLI6J 10-day embryo Mus musculus cDNA clone Mus musculus 26105291-107, mRNA sequence.

ab4OcO8.rl Stratagene HeLa cell s3 937216 Homo sapiens cDNA clone Homo sapiens IMAGE:843278 nnRNA sequence.

ab4OcO8rl Stratagene HeLa cell s3 937216 Homo sapiens cDNA clone Homo sapiens IMAGE:843278 mRNA sequence.

BAC sequence from the SPG4 candidate region at 2p21-2p22. complete Homo sapiens Homo sapiens clone CIT978SKB 65D22, SEQUENCING IN PROGRESS ~,Homo sapiens unordered pieces.

Homo sapiens clone CIT978SKB_65022, SEQUENCING IN PROGRESS *,Homo sapiens unordered pieces.

Caenorhabditis elegans chromosome IV clone Y62E1 0, SEQUENCING IN Caenorhabditis elegans PROGRESS in unordered pieces.

Caenorhabditis elegans chromosome IV clone Y62E10, SEQUENCING IN Caenorhabditis elegans PROGRESS in unordered pieces.

Saccharomyces cerevisiae chromosome I centromere and right arm sequence. Saccharomyces cerevisiae Homo sapiens chromosome unknown clone NH0459119, WORKING DRAFT Homo sapiens SEQUENCE, in unordered pieces.

Homo sapiens chromosome unknown clone NH0459119, WORKING DRAFT Homo sapiens SEQUENCE, in unordered pieces.

Bacillus halodurans C-125 genemic DNA, 32 kb fragment, complete cdls. Bacillus halodurans Streptomyces coelicolor cosmid E8. Streptomyces coelicolor Streptomyces coelicolor histidine kinase homolog (absAl) and response Streplomyces coelicolor regulator homolog (absA2) genes, complete cds.

Homo sapiens chromosome 8 clone 23_-D_-19 map 8, SEQUENCING IN Homo sapiens PROGRESS 27 ordered pieces.

38,129 38,129 37,297 34,120 39,655 34,520 38,163 38,889 37,500 38,816 37,001 38,040 38,040 36,776 36,776 39,260 37,358 37,358 4,622 36,328 39,089 38,658 03-DEC-i1999 03-DEC-i1999 1-Nov-98 3-Jun-99 1 -Nov-98 23-Nov-99 65-Jan-96 1-Jul-99 06-MAR-i 998 06-MAR-i1998 29-Sep-99 06-OCT-i1999 06-OCT-i1999 6-Sep-99 6-Sep-99 05-MAR-i 998 29-OCT-i1999 29-OCT-i 999 14-Apr-99 1 1-MAR-1999 14-Sep-96 14-OCT-1 999 rxa00243 1140 GB_ PR2:CNS0iDS5 GBHTG3:AC01 1408 1408 rxaOO259 2325 GBHTG1:CEY62EiO GBHTGI:CEY62Eio GB-PL2:YSCCHROMl rxa00269 912 GB-HTG4:AC009974 GBHKTG4:AC009974 GB-BA1 :ABOi 7508 rxaGO281 766 GB-BA1:SCE8 GBBA1:SCU51332 GB-HTG4:ACO1 1122 101584 79332 79332 254217 254217 41988 219565 219565 32050 24700 3216 187123 AL12 1655 AC011408 AC01 1408 AL031 580 AL031 580 L22015 AC009974 AC009974 AB017508 AL035654 U51 332 AC01 1122 2006200795 24 Feb 2006 Table 4 (continued) Corynebacteriumn glutamnicumn ectP gene.

rxa00298 1968 GBBA1:CGECTP GBBA1:CGECTP GBEST24:A1234006 2719 AJ001436 2719 AJ001436 Corynebacterium glutamicum ectP gene.

Corynebacterium glutamicum Corynebacterium glutamicum 100,000 20-Nov-98 100,000 20-Nov-98 46,552 31 -Jan-99 rxa00346 813 GBBA1:SC2E9 GBBA1:SC9B1 GBBAI:ECU70214 rxa00368 1698 GBBA2:AF0651 59 GBBA1:AEOCHIT1 GB-EST4:D62996 432 A1234006 EST230694 Normalized rat lung, Bento Soares Rattus sp. cDNA clone Rattus sp.

RLUCU01 3Tend, mRNA sequence.

20850 AL021 530 Streptomyces coelicolor cosmid 2E9. Streptomyces c240 L477Srpoye olclrcsi B.Srpoye 123171 U70214 Escherichia coli chromosome minutes 4-6. Escherichia col 35209 AF065159 Bradyrhizobium japonicum putative arylsulfatase (arsA), putative soluble lytic Bradyrhizobiuni transgrycosylase precursor (stA), dihydrodipicolinate synthase (dapA), MscL- japonicumn (mscL), SmpB (smp6), BcpB3 (bcpB), RnpO (rnpO), ReIASpoT homolog (relA), PdxJ (pdxJ), and acyl carrier protein synthase AcpS (acpS) genes, complete cds: prokaryotic type I signal peptidlase SipF (sipF) gene, sipF-sipS allele, complete cds; RNase Ill (mc) gene, complete cds; GTP-binding protein Era (era) gene, partial cds; and unknown genes.

6861 063139 Aeromonas sp. gene for chitinase, complete and partial cds. Aeromonas sp.

314 D62996 HUM347GO1 B Clontech human aorta polyA+ mRNA (#6572) Homo sapiens Homo sapiens clDNA clone GEN-347G01 mRNA sequence.

119443 AL031866 Yersinia pestis 102 kbases unstable region: from i to 119443. Yersinia pestis 501 AQ012142 8750HlA037010398 Cosmid library of chromosome 11 Rhodobacter sphaeroides Rhodobacter genomic clone 8750H1A037010398, genomic survey sequence. sphaeroides 180096 AC005081 Homo sapiens clone RG270D13, SEQUENCING IN PROGRESS 18 Homo sapiens unordered pieces.

8870 Z30328 Atumefaciens Ti plasmid pTiAch5 genes for OccR, OccQ, OccM, OccP, OccT, Agrobacterium OoxB, OoxA and ornithine cyclodeaminase. tumnefaciens 9829 U67591 Methanococcus jannaschii secion 133 of 150 of the complete genome. Methanococcus :oelicolor 4elicolor 43,267 44.613 39,490 40,409 28-Jan-98 27-Apr-99 21-Sep-96 27-OCT-i1999 l0S-24 38,577 13-Feb-99 41.613 29-Aug-95 35,396 4-Jan-99 54.800 4-Jun-98 rxa00369 817 GBBAI:YP1O2KB GBGSS8:AQ012142 GB_-ITG2:AC005081 GBBA1:ATPLOCC GB-BA2:U67591 GBBA1:TIPOCCOMPJ rxaOO4lO 789 45,786 46,490 45.677 12-Jun-98 I 0-OCT- 1994 28-Jan-98 4350 rxaOO419 882 GBBA2:M5U46844 16951 GBEST28:Al5i3245 471 GBHTG4:AC0iOOG6 187240 M80607 Plasmid pTiA6 (from Agribacteriumn tumnefaciens) periplasmic-type octopine permease (occR. occQ, occM, occP, and occJ) and lysR-type regulatory protein (occR) genes, complete cds.

U46844 Mycobacteriumn smegmatis catalase-peroxidase (katG), putative arabinosyl transferase (embC, embA, embB), genes complete cds and putative propionylcoA carboxylase beta chain (pccB) genes, partial cds.

A1513245 GH133i11.3prime GI- Drosophila melanogaster head pOT2 Drosophila melanogaster cDNA clone GH1331 1 3prime, mRNA sequence.

AC010066 Drosophila melanogaster chromosome 3LJ72A4 clone RPC198-2501, SEQUENCING IN PROGRESS 70 unordered pieces.

Z99118 Bacillus subtilis; complete genome (section 15 of 21): from 2795131 to 3013540.

AL033396 Calbicans cosmid Ca35A5.

AA336266 EST40981 Endometrial tumor Homo sapiens cDNA 5 end, niRNA sequence.

jannaschi Plasmid pTiA6 Mycobacterium smegmatis 46,490 24-Apr-96 57,029 Drosophila melanogaster 37,696 Drosophila melanogaster 39,607 12-MAY-i 997 16-MAR-1 999 16-OCT-i1999 26-Nov-97 5-Nov-98 21-Apr-97 rxa00432 1608 GB-BAi :BSUBO0i 5 GB-PL1:CAC35A5 GBEST13:AA336266 218410 42565 378 Bacillus subtilis Candida albicans Homo sapiens 49,810 35,041 39,733 2006200795 24 Feb 2006 rxa00449 1704 GBHTG2:AC008199 124050 AC008199 GBHTG2:AC008199 124050 AC008199 Table 4 (continued) Drosophila melanogaster chromosome 3 clone BACR01KOB (D756) RPCI-98 01.K.B map 94D-94D strain y; cn bw sp, SEQUENCING IN PROGRESS 83 unordered pieces.

Drosophila melanogaster chromosome 3 clone BACROIK08 (D756) RPCI-98 01.K.8 map 94D-94D strain y; cn bw sp, SEQUENCING IN PROGRESS Drosophila melanogaster 38,392 Drosophila melanogaster 38,392 rxa00456 1500 rxa00477 1767 GBRO:RATLNKP2 177 GBGSS1:FR0030597 476 GB-GSS5:AQ786587 556 GBG5514:AQ526586 434 GB-EST17:AA610489 407 GB-PRI:HSH33G4 1015 GBEST3O:A1637667 579 GBHTG3:AC008708 83932 GBHTG3:AC008708 83932 GB-HTG3:AC008708 83932 GB-HTG1 :HSJ575L21 94715 GB-ITG1:HSJ575L21 94715 rxa00478 954 83 unordered pieces.

M22337 Rat link protein gene, exon 2.

AL026966 Fugu rubripes GSS sequence, clone 091 C22aF9, genomic survey sequence.

A0786587 HS_3086_81_HOSMR CIT Approved Human Genomic Sperm Library D Homo sapiens genomic clone Plate=3086 CoI=9 Row=P, genonmic survey sequence.

AQ526586 HS_-5198_-Bi_-B03_-SP6E RPCI-1 1 Human Male BAC Library Homo sapiens genomic clone Plate=774 Col=5 Raw=D, genonlic survey sequence.

AA610489 np93e05.sl NCI_CGAP -Thyl Homo sapiens cDNA clone IMAGE:1 1133888 similar to gb:M1 1353 HISTONE H3.3 (HUMAN);, mRNA sequence.

X05857 Human H3.3 gene exon 4.

A1637667 ttlOgl 1.xl NCICGAP-GC6 Homo sapiens cDNA clone IMAGE:2240420 3', mnRNA sequence.

AC008708 Homo sapiens chromosome 5 clone CIT978SKB_78F1, SEQUENCING IN PROGRESS 12 unordered pieces.

AC008708 Homo sapiens chromosome 5 clone CIT978SKB 78F71, ~'SEQUENCING IN PROGRESS 12 unordered pieces.

AC008708 Homo sapiens chromosome 5 clone CIT978SKB 78F1, SEQUENCING IN PROGRESS 12 unordered pieces.

AL096841 Homo sapiens chromosome 1 clone RP4-575L-21, SEQUENCING IN PROGRESS in unordered pieces.

AL096841 Homo sapiens chromosome 1 clone RP4-575L-21, SEQUENCING IN PROGRESS in unordered pieces.

AC005960 Mus musculus chromosome 17 BAC citb20h22 from the MHC region, complete sequence.

AL109848 Streptomyces coelicolor cosmid 151.

Rattus sp.

Fugu rubripes Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens Mus musculus 40,678 47,407 38,406 36,951 41,791 38,182 35,417 38,769 38,769 36,797 38.138 38,138 2-Aug-99 2-Aug-99 27-Apr.93 25-Jun-98 3-Aug-99 1 1-MAY-1999 09-DEC-1 997 24-Jan-96 27-Apr-99 3-Aug-99 3-Aug-99 3-Aug-99 c 23-No-99 23-Nov-99 rxaOO480 1239 GBRO:AC005960 158414 40745 38,712 01-DEC-1998 rxa00524 433 GB-BA1 :SC151 Streptomyces coelicolor 40,284 A3(2) GBBA2:AF082879 GBBA1:B5P132617 rxa00526 813 GBBA1:BSUBOOO8 GB_8A2:AF012285 GBBA1:D90725 rxa00559 1140 GBBA2:CAU77910 GBEST4:H34952 3434 AF082879 Yersinia enterocolitica ABC transporter enterochelin/enterobactin gene cluster, Yersinia enterocol complete sequence.

5192 AJ132617 Burkholderia sp. P-transporter operon and flanking genes. Burkholderia sp.

208230 Z99111 Bacillus subtilis complete genome (section 8 of 21): from 1394791 to 1603020. Bacillus subtilis 46864 AF012285 Bacillus subtilis mobA-nprE gene region. Bacillus subtilis 13796 D90725 Escherichia coli genomic DNA. (19.7 20.0 min). Escherichia coli 3385 U77910 Corynebacterium ammoniagenes sequence upstream of the 5-phosphoribosyl-1- Corynebacteriumn pyrophosphate amnidotransferase (purF) gene. ammoniagenes 382 H34952 EST108261 Rat PC-12 cells, untreated Rattus sp. cDNA clone RPCCK07 similar Rattus sp.

to NADH-ubiquinone oxidoreductase complex I123 kDa precursor (iron-sulfur protein), mRNA sequence.

22014 AE000963 Archaeoglobus fulgidlus section 144 of 172 of the complete genome. Archaeoglobus ful itica 55,634 40,793 54,534 54,534 51 .481 39,007 1 6-Aug-99 20-OCT-i1999 13-Jul-99 26-Nov-97 1-Jul-98 7-Feb-99 1-Jan-98 39,267 2-Apr-98 GB-BA2:AE000963 gidus 38,338 15-DEC-1997 2006200795 24 Feb 2006 rxaOO570 852 rxaOO571 1280 rxaOO590 1288 rxaOO591 1476 GBGSS12:AQ422451 GBE5T28:A1504741 GB_ESTI 8:AA712043 GBBAI :MTCY78 GBPR3:AC005788 GBPR3AC005338 GBHTG6:AC010932 GBHTG6:AC010932 GIB BAl :MSGB26CS GBINI:CEKO9E9 GBPR4:AF135802 Table 4 (continued) 563 AQ422451 RPCI-1 1-1 85C3.1V RPCI-11 1 Homo sapiens genomic clone RPCI-1 1-i 85C3, Homo sapiens genomic survey sequence.

568 A1504741 vl6c0l xl Stratagene mouse Tcell 937311 Mus musculus cONA clone Mus musculus IMAGE:972384 3' similar to gb:Z14044 M.musculus mRNA for valosin-containing protein (MOUSE);, rnRNA sequence.

68 AA712043 vu29f1O.rl Barstead Mouse myotubes MPLRB5 Mus musculus cDNA clone Mus musculus IMAGE:1 182091 5' similar to gb:L05093 SOS RIBOSOMAL PROTEIN L18A (HUMAN);, mRNA sequence.

33818 Z77165 Mycobacterium tuberculosis H37Rv complete genome; segment 145/162. Mycobacteriumr 3622 3454 2032 2032 3704 3009 4965 38.767 23-MAR-i1999 1 ~73 AC005788 AC005338 AC01 0932 ~73 AC010932 I0 18 178816 Z79602 AF135802 tuberculosis Homo sapiens chromosome 19, cosmid R26652, complete sequence. Homo sapiens Homo sapiens chromosome 19, cosmid R31646, complete sequence. Homo sapiens Homo sapiens chromosome 15 clone RP1 1-296E22 map 15, SEQUENCING Homo sapiens IN PROGRESS 36 unordered pieces.

Homo sapiens chromosome 15 clone RP1 1-296E22 map 15, -SEQUENCING Homo sapiens IN PROGRESS 36 unordered pieces.

Mycobacterium leprae cosmid 826 DNA sequence. Mycobacteriumn leprae Caenorhabditis elegans cosmid KOSE9, complete sequence- Caenorhabditis elegans Homo sapiens thyroid hormone receptor-associated protein complex component Homo sapiens TRAP170 mRNA, complete cds.

Homo sapiens transcriptional co-activator CRSP150 (CRSP150) mRNA, Homo sapiens complete cds.

Homo sapiens chromosome 19, CIT-HSP-87m17 BAC clone, complete Homo sapiens H-omo sapiens chromosome 19, CIT-I-SP-87m1 7 BAC clone, complete Homo sapiens Human mRNA for collagen binding protein 2, complete cdls. Homo sapiens Mycobacterium tuberculosis H37Rv complete genome; segment 119/162. Mycobacterium 37,900 42,647 38,468 36,911 36,911 37,242 36,485 39,272 34,092 36,310 36,617 34.32 1 35,739 40,404 40.862 38,833 60,552 51,992 51.992 11 -MAR-1 999 24-DEC-i1997 17-Jun-98 06-OCT-i1998 30-Jul-98 30-Nov-99 30-Nov-99 15-Jun-96 2-Sep-99 9-Apr-99 4-Feb-99 02-MAY-i1998 02-MAY-i 998 6-Feb-99 23-Jun-99 23-Jun-99 17-Jun-98 5-Aug-96 12-DEC-i 997 GBPR4:AF104256 nxa00596 576 GBPR3:AC004659 GB PR3:AC004659 GBPRI:-UMCBP2 rxaOO607 504 GBBA1:MTVO1O GBBAI:MTV01O 4365 AF104256 129577 129577 2047 3400 AC004659 ACC04659 D83174 AL021186 3400 AL021 186 Mycobacterium tuberculosis H37Rv complete genome; segment 1ig/i162.

tuberculosis Mycobacteriumn tuberculosis rxa00623 1461 GBBA1:MTCY428 26914 Z81451 Mycobacterium tuberculosis H37Rv complete genome: segment 107/162.

GBBA1:RSPNGR234 34010 Z68203 Rhizobium sp. plasmid NGR234a DNA.

GB_BA2:AEOOO1O1 10057 AE0CO1l0l Rhizobium sp. NGR234 plasmid pNGR234a, section 38 of 46 of the complete plasmid sequence.

Mycobacterium tuberculosis Rhizobium sp.

Rhizobium sp. NGR234 rxa00681 rxa00690 1269 GB-FTG5:AC008338 136685 AC008338 GB-IfTG4:AC009766 170502 AC009766 Drosophila melanogaster chromosome X clone BACR3OJ104 (D908) RPCI-98 Drosophila melanogaster 35,341 30J.4 map 19C-1 9E strain y; cn bw sp. **SEQUENCING IN PROGRESS 93 unordered pieces.

Homo sapiens chromosome 11 clone 404- A -03 map 11, -SEQUENCING IN Homo sapiens 37,984 PROGRESS 27 unordered pieces.

15-Nov-99 19-OCT-i1999 2006200795 24 Feb 2006 GB-HTG4:AC009766 rxa00733 1008 GBEST3O:AU054038 GB-EST30:AU054038 rxa00735 692 GB-BA1:MTCY50 GBBA1:D90904 GBBA1:D90904 rxa00796 298 GBGSS14:AQ579838 GBPR4:AC007625 GB-EST4:AA427576 rxa00801 756 GBBA1:M1V022 GBRO:ACOO2iO9 GB-BA1 :MTVO22 rxa00802 837 GB-GSS14:AQ563349 GB_BA1:IJIHCLPBA GB_GSS3:B61538 rxaOO8lS 1452 GB -HTG3:AC008691_ 1 GBHTG3:AC009127 rxa0O821 966 GBHTG1:HS32B1 GBHTG1:HS32B1 GBPR3:AC004919 rxa00827 876 GB_EST6:W06539 170502 245 245 36030 150894 150894 651 174701 580 13025 160048 13025 642 2441 698 110000 110000 186591 271488 271488 75547 300 Table 4 (continued) AC009766 Homo sapiens chromosome 11 clone 404_A_03 map ii, -SEQUENCING IN PROGRESS 27 unordered pieces.

AU054038 AU054038 Dictyostelium discoideum SL (H.Urushihara) Dictyostelium discoideum cDNA clone SLIK472, mRNA sequence.

AU054038 AU054038 Dictyostelium discoideum SL (H.Urushihara) Dictyostelium discoideum cDNA clone SLK472, mRNA sequence.

Z77137 Mycobacterium tuberculosis H37Rv complete genome; segment 55/1162.

D90904 Synechocystis sp. PCC6803 complete genome, 6/27, 630555-781448.

D90904 Synechocystis sp. PCC6803 complete genome, 6/27, 630555-781448.

AQ579838 Ti 35342b shotgun sub-library of BAG clone 31 P06 Medicago truncatula genomic clone 31-P-06-C-054, genomic survey sequence.

AC007625 Genomic sequence of Homo sapiens clone 2314F2 from chromosome 18, complete sequence.

AA427576 zw54b04.sl Soares -total -fetus -Nb2HF8_9w Homo sapiens cDNA clone IMAGE:773839 3'similar to gb:M86852 PEROXISOME ASSEMBLY FACTOR-i1 (HUMAN);, mRNA sequence.

AL021925 Mycobacterium tuberculosis H-37Rv complete genome; segment 100/162.

AC002109 Genomic sequence from Mouse 9, complete sequence.

AL021925 Mycobacterium tuberculosis H-37Rv complete genome; segment 100/162.

AQ563349 HS..5335_B2_A09_T7A RPCI-11 Human Male BAG Library Homo sapiens genomic clone Plate=911 Col=18 Row=B, genomic survey sequence.

M32229 B.nodosus cIpB gene encoding a regulatory subunit of ATP-dependent protease.

B61 538 Ti 71 7TR TAMU Arabidopsis thaliana genomic clone Ti 71V1 7, genomic survey sequence.

AC008691 Homo sapiens chromosome 5 clone CIT978SKB_63A22, -SEQUENCING IN PROGRESS 253 unordered pieces.

AC008691 Homo sapiens chromosome 5 clone CIT978SKB_63A22, SEQUENCING IN PROGRESS 253 unordered pieces.

AC009127 Homo sapiens chromosome 16 clone RPCI-11_498D1 0. SEQUENCING IN PROGRESS 49 unordered pieces.

AL023693 Homo sapiens chromosome 6 clone RP1-32B1, **SEQUENCING IN PROGRESS in unordered pieces.

AL023693 Homo sapiens chromosome 6 dlone RP1-32B1, -SEQUENCING IN PROGRESS in unordered pieces.

AC004919 Homo sapiens PAC clone DJ0895B23 from UL, complete sequence.

W06539 T2367 MVAT4 bloodstream form of serodeme WRATati. I Trypanosoma brucei rhodesiense cDNA mRNA sequence.

Homo sapiens 37,984 Dictyostelium discoideumn 43,265 Dictyostelium discoideum 43,265 Mycobacterium tuberculosis Synechocystis sp.

Synechocystis sp.

Medicago truncatula Homo sapiens Homo sapiens Mycobacterium tuberculosis Mus musculus Mycobacterium tuberculosis Homo sapiens Dichelobacter nodosus Arabidlopsis thaliana Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens Trypanosoma brucei rhodesiense 36,819 52.585 39.699 37,153 38,014 42.731 59.350 39,398 36,842 37,649 41,140 36,946 38,270 38.270 38,947 36,565 36,565 34.346 40.000 19-OCT-i 999 28-Apr-99 28-Apr-99 17-Jun-98 7-Feb-99 7-Feb-99 27-Sep-99 30-Jun-99 1 6-OCT-i1997 17-Jun-98 9-Sep-97 17-Jun-98 29-MAY-i 999 26-Apr-93 21-Nov-97 3-Aug-99 3-Aug-99 3-Aug-99 23-Nov-99 23-Nov-99 19-Sep-98 1 2-Aug-96 GBPR4:AC008179 181745 AC008179 Homo sapiens clone NH0576F701, complete sequence.

Homo sapiens 35,903 28-Sep-99 2006200795 24 Feb 2006 GBEST18:AA710415 533 AA710415 rxa00842 1323 rxa00B47 1572 GBPR2:AC002379 GBPR2:AC002379 GBIN1:CEFO2D8 GBOV:XELRDS38A GBHTG4:AC007920 118595 118595 31624 1209 234529 ACC02379 AC002379 Z7841 1 L79915 AC007920 Table 4 (continued) vt53f08.rl Barstead mouse irradiated colon MPLRB7 Mus musculus cDNA clone Mus musculus IMAGE: 1166823 mRNA sequence.

Human BAC clone GS165104 from 7q21, complete sequence. Homo sapiens Human BAC clone GS1 65104 from 7q21, complete sequence. Homo sapiens Caenorhabditis elegans cosmid F02D8, complete sequence. Caenorhabditis elegans Xenopus laevis rdslperipherin (rds38) mRNA, complete cds. Xenopus laevis Homo sapiens chromosome 3q27 clone RPCI111-208N14, SEQUENCING IN H-omo sapiens PROGRESS unordered pieces.

Homo sapiens chromosome 3q27 clone RPC 1-208N14, SEQUENCING IN Homo sapiens PROGRESS unordered pieces.

Homo sapiens chromosome SEQUENCING IN PROGRESS ~,10 Homo sapiens unordered pieces.

Homo sapiens chromosome 4, SEQUENCING IN PROGRESS ~,10 Homo sapiens unordered pieces.

Human DNA sequence from clone 824F16 on chromosome 20, complete Homo sapiens 41,562 24-DEC-1997 GBHTG4:AC007920 234529 AC007920 36,321 37.284 38,163 36,044 33,742 33,742 39,833 39,833 39,833 23-Jul-97 23-Jul-97 23-Nov-98 30-Jul-97 21-OCT- 1999 rxa0O851 732 GBHTG2:AC004064 GB-HTG2:AC004064 GBPR3:H5J824F16 rxa00852 613 GB_-ITG3:ACO1O12O GB-HTG3:AC010 120 185000 AC004064 185000 AC004064 139330 AL050325 121582 AC010120 121582 AC010120 GBHTG2:AC006898 299308 AC006898 rxa00856 ncaOO870 1635 GB-BA1:STMMSDA 3986 L48550 sequence.

Drosophila melanogaster chromosome 3 clone BACR22N13 (D1061) RPCI-98 Drosophila melanogaster 36,855 22.N.13 map 96F-96F strain y; cn bw sp, -SEQUENCING IN PROGRESS 83 unordered pieces.

Drosophila melanogaster chromosome 3 clone BACR22N13 (131061) RPCI-98 Drosophila melanogaster 36,855 22.N.13 map 96F-96F strain y; cn bw sp, **SEQUENCING IN PROGRESS 83 unordered pieces.

Caenorhabditis elegans clone Y73B36x. SEQUENCING IN PROGRESS 9 Caenorhabditis elegans 36,768 unordered pieces.

Streptomyces coelicolor methytmalonic acid semnialdehyde dethydrogenase Streptomyces coelicolor 63,743 (msdA) gene, complete cds.

Sequence 10 from patent US 5726299. Unknown. 38,850 Sequence 10 from patent US 5693781. Unknown. 38,850 Escherichia coli isopentyl diphosphate isomerase (idi) gene, complete cds. Escherichia coli 54.827 Escherichia coli K-12 MG1655 section 262 of 400 of the complete genome. Escherichia coli 51,416 Escherichia coli K-12 genome; approximately 64 to 65 minutes. Escherichia coli 51,416 Drosophila melanogaster chromosome 2 dlone BACR300319 (135B7) RPCI-98 Drosophila melanogaster 36,592 30.D.19 map 49E-49F strain y; cn bw sp, **SEQUENCING IN PROGRESS 79 unordered pieces.

Drosophila melanogaster chromosome 2 clone BACR300319 (13587) RPCI-98 Drosophila melanogaster 36,592 30.D.19 map 49E-49F strain y; cn bw sp, **SEQUENCING IN PROGRESS 79 unordered pieces.

Caenorhabditis elegans clone Y51F8, SEQUENCING IN PROGRESS 30 Caenorhabditis elegans 36,699 unordered pieces.

21-OCT-1999 9-Jul-98 9-Jul-98 23-Nov-99 24-Sep-99 24-Sep-99 24-Feb-99 GB-PAT-192043 GBPAT:178754 rxa00875 690 GB BA2:AF1 19715 GB BA2:AE000372 GBBAl :ECU28375 rxa00878 1986 GBHTG2:AC007472 GBHTG2:AC007472 713 713 549 12144 55 175 114003 192043 178754 AF119715 AE000372 U28375 AC007472 09-MAY-1 996 01-DEC-1998 3-Apr-98 22-Apr-99 12-Nov-98 08-DEC-1 995 2-Aug-99 2-Aug-99 114003 AC007472 207370 AC006798 GBHTG2:AC006798 25-Feb-99 2006200795 24 Feb 2006 rxaOO880 1968 GBEST4:I-22888 GBGSS13:AQ426858 GBPR1:A5002335 rxa00899 1389 GBBA1:NGU58849 GB_BAi:PLPDHOS

GB-BAI:PDGINTORF

rxaOO902 1333 GBGSS15:AQ606873 GBGSS9:AQ163442 GB_PL1:PSST7O rxa00931 969 GB_GSS1:FR0025208 GB_GSSi:FR0021844 GBGSS12:AQ403344 rxa00941 1440 GB-BA:MTCY18O GBBAI:MTCYi8O GB_BA2:MSGKATG rxa00962 689 GBHTG6:AC010998 GBGSS1:GGA34Oi1 GB-HTG6:AC01 0998 rxa0iO6O 1047 GB-BA1:ECTrN7 GB-IN2:AF1 76377 GBGSS1O:AQ196728 rxa0lOS7 852 GB_BAi:U00016 GB_BAi:SYCGROESL Table 4 (continued) 468 H22888 ym54el2.rl Soares infant brain I NIB Homo sapiens cODNA clone IMAGE:52158 Homo sapiens mRNA sequence.

516 AQ426858 CITBI-El-2578F1.TF CITBI-Ell Homo sapiens genomic clone 2578IF1, genomic Homo sapiens survey sequence.

6289 AB002335 Human mRNA for KIAA0337 gene, complete cds. Homo sapiens 2401 U58849 Neisseria gonorrhoeae pilS6 silent pilus locus. Neisseria gone 3119 L06822 Plasmid pSa (from Escherichia coi) dlihydropteroate synthase gene, 3' end. Plasmid pSa 6747 L06418 Integron ln7 (from Plasmid pDGO100 from Eseherichia coli) integrase (int). Plasmid pDGC aminoglycoside adenylyltransferase (aad), quaternary ammonium compoundresistance protein. dihydiofulate reductase (dhfrX), and dihydropteroate synthase (sull) genes.

581 AQ606873 HS_5404_B2_H05_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens genomic clone Plate=980 Col=10Row=P, genomic survey sequence.

658 A0163442 nbxbOOO7AOlf CUGI Rice BAC Library Oryza sativa genomic clone Oryza sativa nbxbOOO7AO7f, genomic survey sequence.

4974 X69213 P.sativum Psst70 gene for heal-shock protein. Pisum sativumn 612 AL018047 F.rubripes GSS sequence, clone 14510aA8, genomnic survey sequence. Fugu rubripes 252 AL014715 Frubnipes GSS sequence, clone 069K22aG5, genomic survey sequence. Fugu rubripes 593 AQ403344 HS_2257_Bi_603_T7C CIT Approved Human Genomic Sperm Library D Homo Homo sapiens sapiens genomic clone Plate=2257 Col=5 Row--D, genomic survey sequence.

44201 Z97193 Mycobacterium tuberculosis H37Rv complete genome; segment 85/1 62. Mycobacteriurr tuberculosis 44201 Z97193 Mycobacterium tuberculosis H37Rv complete genome; segment 85/162. Mycobacteriun tuberculosis 1745 114268 Mycobacterium tuberculosis ethyl methane sulphonate resistance protein (katG) Mycobacteriurm gene, Send. tuberculosis 144338 AC010998 Homo sapiens clone RP1 1-95116, -SEQUENCING IN PROGRESS 17 Homo sapiens unordered pieces.

990 AJ232089 Gallus gallus anonymous sequence from Cosmid mapping to chromosome 2 Gallus gallus (Cosmid 34 Contig 15), genomic survey sequence.

144338 AC010998 Homo sapiens dlone RP11-95116, -SEQUENCING IN PROGRESS 17 Homo sapiens unordered pieces.

2280 AJO01816 Escherichia coli left end of transposon Tn7 including type 2 integron. Escherichia co 8220 AF176377 Caenorhabditis briggsae CES-1 (ces-1) gene, complete cds; and CPN-1 (cpn.1) Caenorhabditis gene, partial cds.

429 AQ196728 CIT.HSP-238IF4.TR CIT-HSP Homo sapiens genomic clone 2381 F4, genomic Homo sapiens survey sequence.

42931 U00016 Mycobacterium leprae cosmid 81937. Mycobacteriurr 3256 D12677 Synechocystis sp. groES and groEL genes. Synechocystis 37,179 6-Jul-95 rrhoeae '100 li briggsae leprae sp.

sp.

38,447 35,799 40,623 38,966 38,966 37,900 41,885 36,866 37,815 37,698 31,552 37,902 39,140 42,517 39,497 37,970 38,226 38,822 39,921 39,019 58,303 34,593 34,593 24-MAR-i1999 13-Feb-99 20-Jun-96 20-MAR-i 996 20-MAR-i1996 10-Jun-99 12-Sep-98 3-Jul-96 10-DEC-i1997 10-DEC-i1997 13-MAR-1999 17-Jun-98 17-Jun-90 26-Aug-99 08-DEC-i1999 25-Aug-98 08-DEC-i1999 4-Nov-97 09-DEC-i1999 16-Sep-98 01 -MAR-i 994 3-Feb-99 7-Feb-99 GBBA1:D90905 13941 GBBA1:PSEFAOAB 3480 57 D90905 Synechocystis sp. PCC6803 complete genome. 7/27, 781449-920915.

D10390 P. fragi faoA and faoB genes, complete cds.

Synechocystis =0111114 1347 Pseudomonas fragi 5i1,919 2-Feb-99 2006200795 24 Feb 2006 rxaOll36 555 GB-BA1 :AB014757 GBBA1:SC8D9 GB-EST1 1 :AA244557 GB _EST14:AA407673 GB-EST26:A1390328 GB-OVXLXINT1 GB-PR4:AC006054 GBPR4:AC006054 GB-BA1 :SCE39 GBBA1:MSU50335 Table 4 (continued) 6057 AB014757 Pseudomonas sp. 61-3 genes for PhbR, acetoacetyl-CoA reductase. beta- Pseudomonas sp. 61-3 ketothiolase and PHB synthase, complete cds.

38681 AL035569 Streptomyces coelicolor cosmid 8139. Streptomyces coelicolor 379 AA244557 mxO7aOl .rl Soares mouse NML Mus musculus cDNA clone IMAGE:679464 Mus musculus mRNA sequence.

306 AA407673 EST01 834 Mouse 7.5 dpc embryo ectoplacental cane cDNA library Mus Mus musculus musculus cONA clone C0014F02 mRNA sequence.

604 A1390328 mxO7aOl.yl Soares mouse NML Mus musculus cDNA clone IMAGE:679464 Mus musculus mRNA sequence.

1278 X13138 Xenopus laevis int-i mRNA for int-i protein. Xenopus laevis 143738 AC006054 Homo sapiens Xq28 BAC RPCI1 1-382137 (Roswell Park Cancer Institute Human Homo sapiens BAC Library) complete sequence.

143738 AC006054 Hama sapiens Xq28 BAC RPCII 1-382P7 (Roswell Park Cancer Institute Human Homo sapiens BAG Library) complete sequence.

23550 AL049573 Streptomyces coelicolor cosmid E39. Streptomyces coelicolor 5193 U50335 Mycobacterium smegmatis phage resistance (mpr) gene, complete cds. Mycobacterium 50,573 42,200 39,050 26-DEC-i1998 26-Feb-99 10-MAR-i1997 38,562 26-Aug-98 33.136 2-Feb-99 rxaOll38 540 40,038 37,996 36.053 62,357 37,853 31-MAR-i1995 1-Apr-99 1-Apr-99 31 -MAR-I 1999 1-Feb-97 rxaOll72 1578 GBBA1:BACTHRTRN 15467 084213 Bacillus subtilis genome, trnl-feuABC region.

rxa~ll191 1713 GB-PR2:HS1191B2 60828 AL022237 Human DNA sequence from clone 1 191B32 on chromosome 22q13.2-13.3.

Contains part of the BIK (NBK, BP14, BIPi) gene for BCL2-interacting killer (apoptosis-inducing). a 40S Ribososmal Protein S25 pseudogene and part of an alternatively spliced novel Acyl Transferase gene similar to C. elegans C5OD2.7. Contains ESTs, STSs, GSSs, two putative CG islands and genomic marker D22S1 151, complete sequence.

60828 AL022237 Human DNA sequence from clone 1191132 on chromosome 22qi3.2-13.3.

Contains part of the BIK (NBK, BP4, BIPi) gene for BC2-interacting killer (apoptosis-inducing), a 40S Ribososmal Protein S25 pseudogene and part of an alternatively spliced novel Acyl Transferase gene similar to C. elegans, C50D2.7. Contains ESTs, STSs, GSSs, two putative CpG islands and genomic: marker D22S1 151. complete sequence.

smegmatis Bacillus subtilis Homo sapiens Homo sapiens 38,366 53,807 6-Feb-99 Co 23-Nov-99 W.

GBPR2:HS1I91B2 39,595 23-Nov-99 554 rxa0l212 1047 rxa01219 1005 GBBAl :MTCY373 GBPL1:ATY1 2776 GBPL2:A1T6K21 GBBA2:5CD25 GB-BA1:SLGLYUB GBBA1:SCHIO GBPAT:A68024 GBPATA68025 GBPATA68027 35516 Z73419 Mycobacterium tuberculosis H37Rv complete genome; segment 57/162.

38483 99643 41622 2576 39524 520 193 193 Y12776 AL021889 ALI 18514 X65556 AL049754 A68024 A68025 A68027 Arabidopsis thaliana DNA, 40 kb surrounding ACS1 locus.

Arabidopsis thaliana DNA chromosome 4, BAG clone T6K21 (ESSA project).

Streptomyces coelicolor cosmid 025.

S.Iividans tRNA-GIyU beta gene.

Streptomyces coelicolor cosmid H10.

Sequence 19 from Patent W09743409.

Sequence 20 from Patent W09743409.

Sequence 22 from Patent W09743409.

Mycobacteriumn tuberculosis Arabidopsis thaliana Arabidopsis thaliana Streptomyces coelicolor A3(2) Streptomyces lividans Streptomyces coelicolor unidentified unidentified unidentified 57,762 32,971 35,273 39,654 54,493 44,638 42,553 43,229 38,342 17-Jun-98 7-Sep-98 16-Aug-99 21-Sep-99 20-DEC-i1993 04-MAY-i1999 05-MAY-i1999 05-MAY-i1999 05-MAY-1 999 2006200795 24 Feb 2006 rxa0i22O 1200 rxa01221 849 rxa01222 822 nca0l260 1305 GBPR3:HS51 2B1 1 GB-EST6:N99239 GBEST16:AA554268 GBPR4:AF179633 GBVI:EHVU20824 GBBA2:AE000407 GIBPAT:AR068625 GBBA2:SSU51197 GB-INI:BBU4491 8 GBSAl :CGLPD Table 4 (continued) 64356 AL031058 Human DNA sequence from clone 5121311 on chromosome 6p24-25. Contains Homo sapiens the Desmoplakin I (DPI) gene, ESTs, STSs and GSSs, complete sequence.

424 N99239 zb76hll1.s1 Soares-senesceitfibroblastsNbH-SF Homo sapiens cDNA clone Homo sapiens IMAGE:309573 3T, mnRNA sequence.

400 AA554268 nk36c09.sl NCI_-CGAP -GC2 Homo sapiens cONA clone IMAGE:1015600 3' Homo sapiens similar to gb:XO1 677 GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE.

LIVER (HUMAN);, mnRNA sequence.

96371 AF1 79633 Homo sapiens chromosome 16 map 16q23.3-q24.1 sequence. Homo sapiens 184427 U20824 Equine herpesvirus 2, complete genome. Equine herpes 10601 AE000407 Escherichia coi K-12 MG1655 section 297 of 400 of the complete genome- Escherichia co 28804 AR068625 Sequence 1 from patent US 5854034. Unknown.

28804 U51 197 Sphingomonas S88 sphingan polysaccharidle synthesis (spsG). (spsS). (spsR). Sphingomonas glycosyl transferase (spsQ), (spsl), glycosyl transferase (spsK), glycosyl transferase (spsL), (spsJ), (spsF), (spsD), (spsC). (spsE), Urf 32. Urf 26, ATP-binding cassette transporter ATP-bindling cassette transporter (atrB), glucosyl-isoprenyiphosphate transferase (spsB), glucose-i -phosphate thymidylyltra nsfe rase (rhsA). dTOP-6-deoxy-D-glucose -3,5-epimerase (rhsC) dTDP-0-glucose-4,6-dehydratase (rhsB). dTDP-6-deoxy-L-ma nnosedlehydrogenase (rhsD), Urf 31, and Uf 34 genes, complete cdls.

2791 U44918 Babesia bovis ATP-binding protein (babc) mRNA, complete ccls. Babesia bovis 1800 Y16642 Corynebacterium glutamicum lpd gene, complete COS. Corynebacteiu virus 2 sp. S88 36,111 40,199 37,001 39,471 40,574 40,574 39.228 99,923 59,056 36,270 35,478 23-Nov-99 39,623 20-Aug-96 8-Sep-97 5-Sep-99 2-Feb-96 12-Nov-98 29-Sep-99 18-MAY-i1996 9-Aug-97 1-Feb-99 17-Jun-98 5-Sep-98 1-Feb-99 1 6-OCT-i1999 16-OCT-1 999 m GBBA1:MTVO38 GBPR3:AC005618 rxa0126i 294 GB_BA1:CGLPD GBHTG4:AC010045 GBHTG4:ACO1004S rxa01269 564 GBBA2:AF125164 GBBA1 :AB002668 GB,,BA1 :ABO1 0415 16094 AL021933 Mycobacterium tuberculosis H37Rv complete genome: segment 24/i162.

glutamicum Mycobacterium tuberculosis Homo sapiens 176714 AC005618 1800 Y16642 Homo sapiens chromosome 5, BAC clone 249h5 (LBNL Hi 49), complete sequence.

Corynebacterium glutamicum lpd gene, complete CDS.

Corynebacterium 100,000 glutamicum 164829 AC010045 Drosophila melanogaster chromosome 3LJ75A1 clone RPC198-17C17. Drosophila melanogaster 50,512 SEQUENCING IN PROGRESS 50 unordered pieces.

164829 AC010045 Drosophila melanogaster chromosome-3L175A1 clone RPCI98-17C1 7, Drosophila melanogaster 50,512 SEQUENCING IN PROGRESS 50 unordered pieces.

26443 AF1 25164 Bacteroides fragilis 638R polysaccharidle 6 (PS B2) biosynthesis locus. complete Bacteroides fragilis 56,071 sequence; and unknown genes.

24907 AB002668 Actinobacillus actinomycetemcomitans DNA for glycosyltransferase lytic Actinobacillus 46,679 transglycosylase, dTDP-4-rhamnose reductase. complete cds. actinomycetemcomitans 23112 ABO10415 Actinobacillus actinomycetemcomitans gene cluster for 6-deoxy-L-talan Actinobacillus 46,679 synthesis, complete cdls. actinomycetemcomitans 238 AU027820 Rattus norvegicus, OTSUKA clone, 0T78.02/1i8b07, microsatellite sequence, Rattus norvegicus 34,874 sequence tagged site.

238 AU027820 Rattus norvegicus, OTSUKA clone, 0T78.02/918b07, microsatellite sequence, Rattus norvegicus 34,874 sequence tagged site.

01-DEC-i1999 21-Feb-98 13-Feb-99 02-MAR-i1999 02-MAR-i 999 rxa0l29l 1056 GB-STS:AU027820 GB-STS:AU027820 2006200795 24 Feb 2006 rxa01292 1308 rxa01293 450 GBHTG3:AC006445 174547 GBBA1:BSUBO017 217420 GB-HTG3:AC010580 121119 GB-HTG3:AC010580 121119 GB-GSS8:A0001809 705 GBGSS8:AQ001809 705 GBPLI:MGU60290 4614 GB-HTG3:ACO1 1371 189187 GBHTG3:AC01 1371 189187 GBHTG4:AC009892 138122 Table 4 (continued) AC006445 Homo sapiens chromosome SEQUENCING IN PROGRESS -,7 unordered pieces.

Z99120 Bacillus subtilis complete genomne (section 17 of 21); from 3197001 to 3414420.

AC~lOSBO Drosophila melanogaster chromosome 3 clone BACR48J106 (01 102) RPCI-98 48.J.6 map 96F-96F strain y; cii bw sp, SEQUENCING IN PROGRESS Homo sapiens Bacillus subtilis 37,802 Drosophila melanogaster 35,637 71 unordered pieces.

AC01l0580 Drosophila melanogaster chromosome 3 clone BACR48JO06 (DI 102) RPCI-98 Drosophila melanogaster 35.637 48.J.6 map 96F-96F strain y; cii bw sp, **SEQUENCING IN PROGRESS 71 unordered pieces.

AQO001809 CIT-HSP-229001 7.TF CIT-HSP Homo sapiens genomic clone 2290D1 7, Homo sapiens 42,021 34,812 15-Sep-99 26-Nov-97 01 -OCT-1999 01-OCT-i 999 26-Jun-98 genomic survey sequence.

AQ001 809 CIT-HSP-229001 7.TF CIT-HSP Homo sapiens genomic clone 2290017.

genomic survey sequence.

Homo sapiens 40,323 26-Jun-98 rxa01339 1111 rxa01382 1192 rxa01399 1142 GBHTG4:AC009892 GBPR3:AC002416 GBEST9:AA096601 GBEST37:A1982114 GB.OV:GGU20766 GBHTG2:AC005690 GBHTG2:AC005690 GB-HTG2:AC006637 138122 128915 524 626 1645 193424 193424 22092 U60290 Magnaporthe grisea nitrogen regulatory protein (NUTI) gene, complete cds. Magnaporthe grisea AC01 1371 Homo sapiens chromosome 5 clone CIT978SKB_107C20, SEQUENCING IN Homo sapiens PROGRESS 31 unordered pieces.

AC01 1371 Homo sapiens chromosome 5 clone CIT978SKB_107C20, SEQUENCING IN Homo sapiens PROGRESS 31 unordered pieces.

AC009892 Homo sapiens chromosome 19 clone CIT978SKB_83J4, SEQUENCING IN Homo sapiens PROGRESS 6 ordered pieces.

AC009892 Homo sapiens chromosome 19 clone CIT978SKB_83J4, SEQUENCING IN Homo sapiens PROGRESS 6 ordered pieces.

AC002416 Human Chromosome X, complete sequence. Homo sapiens AA096601 moO3b9.r1 Stratagene mouse lung 937302 Mus musculus cDNA clone Mus musculus IMAGE:552473 5' similar to gb:L06505 60S RIBOSOMAL PROTEIN L 12 (HUMAN); gb:L04280 Mus musculus ribosomal protein (MOUSE);, mRNA A19821 14 pat.pk0074.e9.f chicken activated T cell cONA Gallus gallus cONA clone Gallus gallus pat.pk0074.e9.f 5, similar to H-ATPase B subunit, mRNA sequence.

U20766 Gallus gallus vacuolar H+-ATPase B subunit gene, complete cdls. Gallus gallus AC005690 Homo sapiens chromosome 4, SEQUENCING IN PROGRESS Homo sapiens unordered pieces.

AC005690 Homo sapiens chromosome 4, -SEQUENCING IN PROGRESS H-omo sailens 38,707 39,741 39,741 40,154 40,154 37,521 40,525 37,785 38,244 37,464 37,464 3-Jul-96 06-OCT-i1999 06-OCT-1999 31-OCT-i1999( 31-OCT-i1999 29-Jan-93 15-Feb-97 15-Sep-99 07-DEC-i1995 11I-Apr-99 11-Apr-99 23-Feb-99 3-Dec-98 3-Dec-98 12-Jan-99 2-Apr-98 rxa0l42O 1065 rxa01467 414 rxa01 576 882 GB_-HTGI:CEY1O2G3_ 110000 GB_-HTG1:CEY1O2G3_ 110000 GB HTG1:CEYl 1 3G7_ 110000 GBBA2:AF030975 2511 AC006637 AL020985 AL020985 AL031 113 AF030975 unordered pieces.

Caenorhabditis elegans clone F41 84, SEQUENCING IN PROGRESS -,1 unordered pieces.

Caenorhabditis elegans chromosome V clone Y102G3. SEQUENCING IN Caenorhabditis elegans chromosome V clone Y102G3. SEQUENCING IN Caenorhabditis elegans chromosome V clone Y1 13G7, *SEQUENCING IN Aeromonas salmonicida chaperonin GroES and chaperonin GroEL genes, complete cds.

Aeromonas salmonicida cliaperonin GroES and chaperonin GroEL genes.

complete cds.

Caenorhabditis elegans 37,488 Caenorhabditis elegans Caenorhabditis elegans Caenorhabditis elegans Aeromonas salmonicida 35,437 35,437 35,437 4 1,516 GB-BA2:AF030975 2511 AF030975 Aeromonas salmonicida 38.171 2-Apr-98 2006200795 24 Feb 2006 rxa01580 840 GBEST22:A1068560 GB-GSS 14:AQ554460 GB-IN2:AC005449 GB_1N2:AC005449 965 681 85518 85518 A106MO6 AQ554460 AC005449 AC005449 rxa0l 584 nca01604 771 rxa0l6i4 1146 ,xa01629 1635 rxa01644 1401 rxa01667 1329 1xa01722 1848 GBHTG3:ACO1 1352 160167 GBHTG3:AC011352 160167 GBHTG3:AC01 1402 168868 GBBA1:CGA224946 2408 GBEST17:AA608825 439 GBPR4:AC005377 102311 GBBA1:CGPROPGEN 2936 GBBA1:CGPROPGEN 2936 GB PR4:AF1 91 071 88481 GBBA1:MSGB57700 37770

S

GB-BA1 :MLCB24O7 35615 GBBA1:M1V025 121125 GBBAI:CGU43536 3464 GBHTG4:AC009841 164434 GB-HTG4.ACoog84l 164434 GB GSS1 :FR0022586 522 GBGSS1:FR0022584 485 GB-lNi:CET26H2 37569 AC01 1352 AC01 1352 AC011402 AJ224946 AA608825 AC005377 Y12537 Y12537 AF191071 L01 263 AL023596 AL022 121 U143536 AC009841 AC009841 AL015452 AL01 5450 Z82055 Table 4 (continued) mgaeooo3aCl lf Magnaporthe grisea Appressorium Stage cDNA Library Pyricularia gnisea cONA clone mgaeOOO3aC1l f 5, mRNA sequence.

RPCI-1 1-419F2.TV RPCI-1 1 Homo sapiens genomic clone RPCI-1 1419F2, genomic survey sequence.

Drosophila melanogaster, chromosome 2R, region 44C4-44C5, P1 clone 0506765, complete sequence.

Drosophila melanogaster, chromosome 2R, region 44C4-44C5, P1 clone 0506765, complete sequence.

Homo sapiens chromosome 5 clone CIT-HSPC_327F10, SEQUENCING IN PROGRESS 15 unordered pieces.

Homo sapiens chromosome 5 clone CIT-HSPC_327F10, SEQUENCING IN PROGRESS 15 unordered pieces.

Homo sapiens chromosome 5 clone CIT978SKB_38B5, SEQUENCING IN PROGRESS 7 unordered pieces.

Corynebacterium glutamicum DNA for L-Malate:quinone oxidoreductase.

afO3gD7.sl Soares -testis_-NHT Homno sapiens cDNA clone IMAGE:i1030620 3' similar to TR:G976083 G976083 H-ISTONE H2A RELATED. mRNA sequence.

Homo sapiens PAC clone DJIi 136G02 from 7q32-q34. complete sequence.

C.glulamicum proP gene.

Oglutamioum proP gene.

Homo sapiens chromosome 8 clone BAC 388D06, complete sequence.

M. leprae genomic dna sequence, cosmid b577.

Mycobacterium leprae cos mid 82407.

Mycobacterium tuberculosis H37Rv complete genome; segment 155/162- Corynebacterium glutamicumn heat shock, ATP-bindling protein (c~pB) gene.

complete cdls.

Drosophila melanogaster chromosome 31J77E1 clone RPCI98-13F1 1, SEQUENCING IN PROGRESS- 70 unordered pieces.

Drosophila melanogaster chromosome 3lJ77E1 clone RPCI98-1 3F1 1, SEQUENCING IN PROGRESS unordered pieces.

F.rubnipes 055 sequence, clone 077P23aB1 0, genomio survey sequence.

F.rubripes 055 sequence, clone 077P23aB1 1, genomic survey sequence.

Caenorhabditis etegans cos mid T261-2. complete sequence.

Pyricularia grisea Homo sapiens Drosophila melanogaster Drosophila melanogaster Homo sapiens Homo sapiens H-omo sapiens Corynebacteriumn glutamnicumn Homo sapiens Homo sapiens Corynebacteriumn glutamnicumn Corynebacteriumn glutamicum Homo sapiens Mycobacteriumn leprae Mycobacteriumn leprae Mycobacteriumn tuberculosis Corynebacteriurn glutamicum 40,073 36,522 36,609 33,612 33,688 33,688 33,688 42,284 40,092 37,811 100,000 100,000 35,612 55,604 36,416 55,844 100,000 09-DEC-i1999 28-MAY-i1999 23-DEC-i1998 23-DEC-i1998 06-OCT-1 999 06-OCT-i 999 06-OCT-i1999 11 -Aug-98 02-MAR-1998 28-Apr-99 17-Nov-98 17-Nov-98 1 1-OCT-i1999 14-Jun-96 27-Aug-99 24-Jun-99 13-MAR-1997 1&6OCT-i 999 16-OCT-1 999 10-DEC-i1997 10-DEC-i1997 19-Nov-99 Drosophila melanogaster 33,205 Drosophila melanogaster 33,205 Fugu rubripes 40.192 Fugu rubripes 35,876 Caenortiabditis elegans 34.759 2006200795 24 Feb 2006 fxa01727 1401 GB_BA2:CORCSLYS 2821 M89931 GBHTG6:ACO1 1037 GBHTG6:ACO1 1037 rxa01737 1182 GB_8A1:SCGD3 GBHTG1 :CNSO1 DSB GBHTG1:CNSOIDSB nca01762 1659 GBBA1:MTCI28 GBBA1 :SC6G1O GBBA1 :SCE29 rxa01764 1056 GB_PL2:SPAC343 GBPL2:SPAC343 rxa0l8Ol 1140 GBEST38:AW066306 GB-GSS1 3:AQ484750 GB-GSS1 3:AQ4 89971 rxa01823 900 GB_BA1:SC15 I GB_BA1:ECU82598 GBBA1:BSUBOO18 rxa01853 675 GBBA1:MTCY227 GBHTG3:AC010189 GBHTG3:AC010189 rxaOl8i 558 GBI-ITG4:AC011117 GB_HTG4:ACO1 1117 GBBAi:MTCY2812 167849 167849 33779 222193 222193 36300 36734 26477 42947 42947 334 375 252 40745 136742 209510 35946 265962 265962 148447 148447 20431 AC01 1037 ACOl 1037 AL096822 AL 121768 AL12 1768 Z97050 AL049497 AL035707 AL1 09739 AL1 09739 Table 4 (continued) Corynebacterium glutamicum beta C-S lyase (aecD) and branched-chain amino acid uptake carrier (brnQ) genes, complete cdls, and hypothetical protein Yhbw (yhbw) gene, partial cds.

Homo sapiens clone RP1 1-7F18, WORKING DRAFT SEQUENCE, 19 unordered pieces.

Homo sapiens clone RPi 1-7F18, WORKING DRAFT SEQUENCE, 19 unordered pieces.

Streptomyces coelicolor cosmid GD3.

Homo sapiens chromosome 14 clone R-970B16, SEQUENCING IN PROGRESS in ordered pieces.

Homo sapiens chromosome 14 clone R-9761316, SEQUENCING IN PROGRESS in ordered pieces.

Mycobacterium tuberculosis H37Rv complete genome: segment 10/162.

Streptomyces coelicolor cosmid 6G 10.

Streptomyces coelicolor cosmid E29.

Spombe chromosome I cosmid c343.

Spombe chromosome I cosmid c343.

Corynebacterium glutamicum Homo sapiens Homo sapiens Streptomyces coelicolor Homo sapiens Homo sapiens Mycobacteriumn tuberculosis Streptomyces coelicolor Streptomyces coelicolor Schizosaccharomyces pombe Schizosaccharomyces pombe AW066306 687009DD3.yl 687 Early embryo from Delaware Zea mays cONA, mRNA sequence.

AQ484750 RPCI-1 1-248N4.TV RPCI-i1 Homo sapiens genomic clone RPCI-1 1-248N4, 99,929 36,903 35,642 38.054 35,147 35,147 49.574 44,049 40,245 37,084 34,890 46,108 32,000 36,111 35.779 39,211 36,999 37,612 39,006 39.006 39,130 39,130 37.893 4-Jun-98 30-Nov-99 30-Nov-99 8-Jul-99 05-OCT-i1999 05-OCT.1999 23-Jun-98 24-MAR-I1999 12-MAR-i 999 6-Sep-99 6-Sep-99 12-OCT-1 999 24-Apr-99 24-Apr-99 16-Aug-99 15-Jan-97 26-Nov-97 17-Jun-98 16-Sep-99 16-Sep-99 14-OCT-i1999 14-OCT-1 999 18-Jun-98 Zea mays Homo sapiens AQ489971 AL1 09848 U82598 Z99121 Z77724 AC01 0189 AC010189 ACO1 1117 AC01 1117 Z81 011 genomic survey sequence.

RPCI-1 1-247N23.1V RPCI-1 1 Homo sapiens genomic clone RPCI-1 1-247N23, H-omo sapiens genomic survey sequence.

Streptomyces coelicolor cosmid 15 1. Streptomyces coelicolor A3(2) Escherichia coli genomic sequence of minutes 9 to 12. Escherichia coli Bacillus subtilis complete genome (section 18 of 21): from 3399551 to 3609060. Bacillus subtilis Mycobacteriumn tuberculosis H37Rv complete genome; segment 114/162. Mycobacterium tuberculosis Homo sapiens clone RPCI1 1-2961<13, SEQUENCING IN PROGRESS ~,80 Homo sapiens unordered pieces.

Homo sapiens clone RPCI1 1-296K13,~ SEQUENCING IN PROGRESS ~,80 Homo sapiens unordered pieces.

Homo sapiens chromosome 4 done 173_C_09 map 4. SEQUENCING IN Homo sapiens PROGRESS 10 ordered pieces.

Homo sapiens chromosome 4 clone 173_C_09 map 4, SEQUENCING IN Homo sapiens PROGRESS 10 ordered pieces.

Mycobactenumr tuberculosis H37Rv complete genome; segment 61/1 62. Mycobacteriumn tuberculosis 2006200795 24 Feb 2006 rxa01894 978 rxa01897 666 rxa01946 1298 rxa0l98O 756 rxa01 983 630 rxaO2O2O 1111 rxa02029 1437 GBBA1:MTCY274 GBIN1:CELF46-5 GB-HTG3:AC009204 GBHTG1:CEY48B6 GBHTG1:CEY48B6 GBHTG1 :CEY53F4-2 GBBAl :M1V007 GBBA1:SCSF2A GBBA1:SCARD1GN GBPL2:AC008262 GBPL1:AB013388 GB,.PLI:ABO 13388 GB-HTG4:AC006467 GB-HTG4:AC006467 GBIITG4:AC006467 GBBA1:CGDNAAROP GBPAT:A58887 GBBAl :STYCARABA GBHTG2:AC003023 GBHTG2:AC003023 GB-ITG2:HS118Bi8 39991 38886 115633 293827 293827 110000 32806 40105 2321 99698 73428 73428 175695 Z74024 U41543 AC009204 AL021 151 AL021 151 Z92860 AL021 184 AL049587 X84374 AC008262 AB013388 AB013388 Table 4 (continued) Mycobacterium tuberculosis H37Rv complete genome; segment 126/1 62.

Caenorhabditis elegans cosmid F46H5.

Drosophila melanogaster chromosome 2 clone BACRO3E1 9 (Di 033) RPCI-98 03.E. 19 map 36E-37C strain y; cn bw sp, **SEQUENCING IN PROGRESS 94 unordered pieces.

Caenorhabditis elegans chromosome 11 clone Y48B6, SEQUENCING IN PROGRESS in unordered pieces.

Caenorhabditis elegans chromosome 11 clone Y48B6, SEQUENCING IN PROGRESS in unordered pieces.

Caenorhabditis elegans chromosome 11 clone Y53F4,~ SEQUENCING IN PROGRESS in unordered pieces.

Mycobacterium tuberculosis H37Rv complete genome: segment 64/162.

Streptomyces coelicolor cosmid 51 2A.

Scapreolus ardi gene.

Genomic sequence for Arabidlopsis thaliana BAC F4N2 from chromosome I, complete sequence.

Arabidopsis thaliana genomic DNA, chromosome 5, TAO clone: K19E1, complete sequence.

Arabidlopsis thaliana genomic DNA, chromosome 5, TAC clone: K19E1, complete sequence.

Mycobacterium tuberculosis Caenorhabditis elegans Drosophila melanogaster Caenorhabditis elegans Caenorhabditis elegans Caenorhabditis elegans Mycobacteriumn tuberculosis Streptomyces coelicolor Streptomyces capreolus Arabidlopsis Ihaliana Arabidopsis tlhaliana Arabidopsis Ihaliana 37,229 38.525 31,579 34,703 34,703 33,333 65,560 50,648 44,973 35,310 35,505 39.973 19-Jun-98 29-Nov-96 18-Aug-99 AC006467 175695 AC006467 175695 AC006467 2612 1612 4378 1104768 104768 104729 X85965 A58887 M95047 AC003023 AC003023 AL034344 Drosophila melanogaster chromosome 2 clone BACRO3LO08 (0532) RPCI-98 Drosophila melanogaster 36,672 031L.8 map 40A-40C strain y; cn bw sp, **SEQUENCING IN PROGRESS 9 unordered pieces.

Drosophila melanogaster chromosome 2 clone BACRO3LO08 (D532) RPCI-98 Drosophila melanogaster 36,672 031L.8 map 40A-40C strain y; cn bw sp, **SEQUENCING IN PROGRESS 9 unordered pieces.

Drosophila melanogasler chromosome 2 clone BACRO3LO08 (D532) RPCI-98 Drosophila melanogaster 32,367 031L.8 map 40A-40C strain y; cn bw sp, SEQUENCING IN PROGRESSo 9 unordered pieces.

C.glutamicum ORF3 and aroP gene. Corynebactedrn 100,000 glutamicum Sequence 1 from Patent W09701637. unidentified 100.000 Salmonella typhimurium transport protein, complete cds, and transfer RNA-Arg. Salmonella typhimurium 50,547 Homo sapiens chromosome 11 clone pDJ363p2, SEQUENCING IN Homo sapiens 35,820 PROGRESS 22 unordered pieces.

Homo sapiens chromosome 11 clone pDJ363p2, SEQUENCING IN Homo sapiens 35,820 PROGRESS 22 unordered pieces.

Homo sapiens chromosome 6 clone RP1-1 18B1 8 map p24.1-25.3, H-omo sapiens 34.355 SEQUENCING IN PROGRESS in unordered pieces.

1 -Apr-99 1 -Apr-99 15-Oct-99 17-Jun-98 24-MAY-1 999 23-Aug-95 21-Aug-99 20-Nov-99 20-Nov-99 27-OCT-i1999 27-OCT-i1999 27-OCT-i1999 30-Nov-97 06-MAR-i1998 1 3-MAR-i1996 21-OCT-1997 21-OCT-1997 03-DEC-1 999 2006200795 24 Feb 2006 rxaO2O3O 1509 rxa02O73 1653 GBPR4:AC007695 GBPR4:AC006464 GBPR4:AC006464 GBBA1:CGGD-A GBBA1:CGGDH GB-BA2:SC2H4 63247 99908 99908 2037 2037 25970 AC007695 AC006464 AC005464 X72855 X59404 AL03 1514 Table 4 (continued) Homo sapiens 12q24 BAC RPCI11-124N23 (Roswell Park Cancer Institute Human BAC Library) complete sequence Hoama sapiens BAC clone NH0436C12 from 2, complete sequence.

Homo sapiens BAC clone Nll0436C12 from 2, complete sequence.

Oglutamicum GOHA gene.

Corynebacterium glutamicum, gdh gen for glutamate dehydrogenase.

Streptomyces coelicolor cosmid 2H-4.

Homo sapiens Homo sapiens Hoamo sapiens Corynebacterium glutamicumn Corynebacteriumn glutamicumn Streptomyces coelicolor A3(2) 38,681 35,445 35,968 39,655 44,444 38,452 1-Sep-99 22-OCT-i1999 22-OCT-1999 24-MAY-i1993 30-Jul-99 19-OCT-i 999 rxa02O74 rxa02095 1527 GBEST18.AA703380 471 rxa02099 373 1197 rxa02128 1818 rxa02133 329 GB-HTG6:AC009769 GBEST7:W70175 GBBA1:CAJ1O3i9 GBHTG3:ACO1 1509 GBHTG3.AC01 1509 GBllTG5:AC010126 GBHTG5:AC010126 GB-PR1:HUMHM 145 GBBA1;MTCY19O GBBA1:MTCY19O GBGSS1O:AQ161109 GB-BA2:MPAE0OOO58 GBHTG4;AC008308 122911 436 5368 111353 111353 175986 175986 2214 34150 34150 738 28530 151373 AA703380 zj1 2b06.sl Soares-fetal liver spleen_1 NFLS_Si llama sapiens cDNA clone IMAGE:450035 3 similar to contains LTR5.t3 LTR5 repetitive element;, mRNA sequence.

AC009769 llama sapiens chromosome 8 clone RP1 1-202112 map 8, LOW-PASS SEQUENCE SAMPLING.

W70175 zd52c02.rl Soares -fetal -heart NbHH19W llama sapiens cONA clone IMAGE:344258 5' similar to contains LTR5.b2 LTR5 repetitive element;. mRNA sequence.

AJO10319 Corynebacterium glutamnicumn amtP, glnB, gInD genes and partial ftsY and srp genes.

AC01 1509 llama sapiens chromosome 19 clone CITB-H1_2189E23, SEQUENCING IN PROGRESS 35 unordered pieces.

AC01 1509 llama sapiens chromosome 19 clone ITB-Hi 2189E23, SEQUENCING IN PROGRESS 35 unordered pieces.

AC01 0126 llama sapiens clone GS502B02, SEQUENCING IN PROGRESS ~,3 unordered pieces.

AC010126 llama sapiens clone GS502B202, SEQUENCING IN PROGRESS ~,3 unordered pieces.

010925 Human mRNA for HM145.

Z70283 Mycobacterium tuberculosis H37Rv complete genome; segment 98/162.

Z70283 Mycobacteriumn tuberculosis ll3lRv complete genome; segment 98/1 62.

A0161 109 nbxbOOODOD3r CUGI Rice BAC Library Oryza saliva genomic clone nbxbOOOSDO3r, genomic survey sequence.

AE000058 Mycoplasma pneumoniae section 58 of 63 of the complete genome.

llama sapiens llama sapiens llama sapiens Corynebacterium gfutamicumn llama sapiens llama sapiens llama sapiens llama sapiens llama sapiens Mycobacterium tuberculosis Mycobacterium tuberculosis Oryza saliva Mycoplasma 36,518 35,473 34,174 100,000 33,423 33,423 36,717 36,092 39,171 38,682 35,746 38,482 32.317 24-DEC-i1997 07-DEC-i1999 16-OCT-1996

CD

(D

14-MAY-i1999 07-OCT-i1999 07-OCT-I1999 13-Nov-99 13-Nov-99 3-Feb-99 17-Jun-98 17-Jun-98 1 2-Sep-98 18-Nov-96 20-OCT-i1999 AC008308 pneumoniae Drosophila melanogaster chromosome 3 clone BACR1OM16 (D743) RPCI-98 Drosophila melanogaster 34.579 10.M.16 map 93C-93D strain y; C41 bw ip, **SEQUENCING IN PROGRESS 186 unordered pieces.

2006200795 24 Feb 2006 rxa02150 924 rxaO2l7l 1776 rxa02173 1575 rxa02224 1920 rxa02225 905 rxa02233 1410 rxa02253 1050 GBHTG4:AC008308 151373 GBE5T37:AW012260 358 GB-GSS3:B87734 389 GB -PR4:AC005042 192218 GBBA2:AF010496 189370 GBEST24:AI1 70522 367 GB-PL1 :PH-VDLECA 1441 GBBA1:CGGLTG 3013 GBBA1:CGGLTG 3013 GBBA2:AEOOO1O4 10146 GBBA2:CXU21300 8990 GB-HTG3:AC009185 87184 GBHTG3:AC009185 87184 GBBA2:MPAEOOOO58 28530 GBEST26:A1337275 618 GBEST26:A1337275 618 GB BA1 :ERWPNLB 1291 GBEST3O:AV021947 313 GBEST33:AV087117 251 GB-EST1 1:AA250210 532 GBEST11:AA250210 532 Table 4 (continued) AC008308 Drosophila melanogaster chromosome 3 clone BACRlOM16 (ID743) RPCI-98 Drosophila melanogaster 34.579 10.M.16 map 93C-93D strain y; cn bw sp, SEQUENCING IN PROGRESS 186 unordered pieces.

AW012260 um06e09.yl Sugano mouse kidney mkia Mus musculus cDNA clone IMAGE:2182312 5' similar to SW:AMPL -BOVIN P00727 CYTOSOL AMINOPEPTIDASE mnRNA sequence.

B87734 RPCI11-3013243TP RPCI-11 IHomo sapiens genomic clone RPCI-1 1-30024, genomic survey sequence.

AC005042 Homo sapiens clone NH0552E01, complete sequence.

AF010496 Rhodobacter capsulatus strain 581003, partial genome.

A1170522 EST216450 Normalized rat lung. Bento Soares Rattus sp. cDNA clone RLUC075 3'end, mRNA sequence.

K03288 P.vulgaris phytohemnagglutinin gene encoding erythroagglutinaling phytohemagglutinin complete cds.

X661 12 C.glutamicum gIt gene for citrate synthase and ORF.

X661 12 Oglutamicum gIt gene for citrate synthase and ORF.

AE000104 Rhizobium sp. NGR234 plasmid pNGR234a, section 41 of 46 of the complete plasmid sequence: U21300 Corynebacterium striatumn hypothetical protein YbhB gene, partial cds; ABC transporter TetB3 (tetB), ABC transporter TetA (tetA), transposase, 23S rRNA methyltransferase, and transposase genes, complete cds; and unknown genes.

AC009185 Homo sapiens chromosome 5 clone CIT-I-SPC_248019, SEQUENCING IN PROGRESS 2 ordered pieces.

AC009185 Homo sapiens chromosome 5 clone CIT-HSPC_248019, SEQUENCING IN PROGRESS 2 ordered pieces.

AE000058 Mycoplasma pneumoniae section 58 of 63 of the complete genome.

A1337275 tb96hl 1 .xl NCI_-CGAP_-Col6 Homo sapiens cODNA clone IMAGE:2062245 3' similar to TR:Q115392 Q1 5392 ORF. COMPLETE 005. mRNA sequence.

A1337275 tb96hl1 1.x1 NCI_CGAP_-Col6 Homo sapiens cONA clone IMAGE:2062245 3' similar to TR:Q15392 Q1 5392 ORF, COMPLETE CDS. mRNA sequence.

M65057 Erwinia carotovora pectin lyase (pnil) gene, complete cdls.

AV021947 AV021947 Mus musculus 18-day embryo C57BlI6J Mus musculus cDNA clone 11 90024M23, mRNA sequence.

AV087117 AV087117 Mus musculus tongue C57BLJ6J adult Mus musculus cDNA clone 2310028C015, mRNA sequence.

AA250210 mx79glO.rl Soares mouse NMVL Mus musculus cDNA clone IMAGE:692610 5' similar to TR:E236517 E236517 F44G4.11 mRNA sequence.

AA250210 mx79g10.rl Soares mouse NML Mus musculus cONA clone IMAGE:692610 5' similar to TR:E236517 E236517 F44G4.1 mRNA sequence.

Mus musculus Homo sapiens Homo sapiens Rhodobacter capsulatus Rattus sp.

Phaseolus vulgaris Corynebacterium glutamicum Corynebacterium glutamicum Rhizobium sp. NGR234 Corynebacterium striatumn Homo sapiens Homo sapiens Mycoplasma pneumoniae Homo sapiens Homo sapiens Erwinia carotovora Mus musculus Mus musculus Mus musculus Mus musculus 39,385 37,629 36.901 53,714 44,186 39,103 44,118 35,189 38.487 37,264 36,459 36,459 35,498 35,589 42,786 37,780 39,423 47,410 36,136 36,202 20-OCT-1 999 10O-Sep-99 9-Apr-99 14-Jan-99 12-MAY-i1998 20-Jan-99 27-Apr-93 17-Feb-95 17-Feb-95 12-DEC-i1997 9-Apr-99 07-OCT-i1999 07-OCT-1 999 1 8-Nov-96 18-MAR-1 999 18-MAR-i 999 26-Apr-93 28-Aug-99 25-Jun-99 12-MAR-1997 12-MAR-1 997 2006200795 24 Feb 2006 rxa02261 1479 rxa02268 1023 rxa02269 1095 rxa02309 1173 rxa02310 1386 rxa02321 1752 rxa02335 1896 rxa02364 750 GBBA1 :CGL007732 4460 GBBA1:CGAMTGENE 2028 GBBA1:CORPEPC 4885 GB_PL2:AF087130 3478 GBEST30:A1663709 408 GBRO:AF074714 3120 GBGSS4:AQ742825 847 GBHTG3:AC009293 16294 GBHTG3:AC009293 16294 GBBA1:MTY25D1O 40838 GBBA1:MSGY224 40051 GBHTG2:AC007163 18661 GB_BAi:MTY25D1O 40838 GB-BA1 :MSGY224 40051 GB_PR3:HS279N11 16999 GB-BAI:AB018531 4961 GBPAT:E17019 4961 GB-BA1 :ABO 18530 2855 GB,,BA1:CGU35023 3195 GB-BA1 :U0012 33312~ GBBA1:MTCY71 42729 GBBA1 :APOOOOO6 31 900 GB-BA1 :APOOOOO6 31 900 w4 Table 4 (continued) AJ007732 Corynebactenium glutamicum 3' ppc gene. secG gene, amt gene, ocd gene and gene.

X93513 C.glutamicum amt gene.

M2581 9 Oglutamicum phosphoenolpyruvate carboxylase gene. complete cds.

AF0871 30 Neurospora crassa siderophore regulation pratein (sre) gene, complete cdls.

A1663709 ud47aO6.yl Soares mouse mammary gland NbMMG Mus musculus; cLINA clone IMAGE:1449010 5' similar to TR:075585 075585 MITOGEN- AND STRESS- ACTIVATED PROTEIN KINASE-2 mRNA sequence.

AF074714 Mus musculus mitogen- and stress-activated protein kinase-2 (mMSK2) mRNA, complete cds.

AQ742825 HS_5482_B2_A04_T7A RPCI-11I Human Male BAG Library Homo sapiens genomic clone Plate=1 058 CoI=8 Row--B, genomic survey sequence.

AC009293 Homo sapiens chromosome 18 clone 53 -I -06 map 18, -SEQUENCING IN PROGRESS 15 unordered pieces.

14 AC009293 IZ95558 AD000004 8 AC007163 IZ95558 AD000004 18 Z98255 AB018531 E17019 ABO1 8530 U35023 U00012 IZ92771 10 AP000006 Homo sapiens chromosome 18 clone 53 I_06 map 18, SEQUENCING IN PROGRESS 15 unordered pieces.

Mycobacteriumn tuberculosis H37Rv complete genome: segment 28/162.

Mycobacteriumn tuberculosis sequence from clone y224.

H-omo sapiens clone NH0091N05, SEQUENCING IN PROGRESS 1 unordered pieces.

Mycobacterium tuberculosis H37Rv complete genome; segment 28/162.

Mycobacteriumn tuberculosis sequence from clone y224.

Human DNA sequence from PAC 279NI 1 on chromosome Xql 1.2-1 3.3.

Corynebactedriu glutamicum dtsRi and dtsR2 genes, complete cds.

Brevibacterium lactofermenturn dtsR and dtsR2 genes.

Corynebacterium glutamicum dtsR gene, complete cds.

Coaynebacterium glutamicum thiosulfate sulfurtransferase (thtR) gene, partial cds, acyl CoA carboxylase (accBC) gene, complete cds.

Mycobacterium leprae cosmid B1308.

Mycobactedriu tuberculosis H37Rv complete genome; segment 141/162.

Pyrococcus horikoshii 0T3 genomic DNA, 1166001-1485000 nt. position Corynebacterium glutamicumn Corynebacterium glutamicum Corynebacterium glutamnicumn Neurospora crassa Mus musculus Mus musculus Homo sapiens Homo sapiens Homo sapiens Mycobacteriumn tuberculosis Mycobacteriumn tuberculosis Homo sapiens Mycobacteriumn tuberculosis Mycobacteriumn tuberculosis Homo sapiens Corynebacteriurn glutamicumn Corynebacterlum glutamicum Corynebacterium glutamicum Corynebacteriumn glutamicum Mycobacterium leprae Mycobacteriumn tuberculosis Pyrococcus horikoshil Pyrococcus horikoshii 100,000 100,000 100,000 39,268 41,523 38,347 37,703 37.006 37,006 52,344 52,344 37,263 36,861 36.861 34,516 99,030 98,973 99,030 99,947 40,247 67,568 36,130 34,543 7-Jan-99 29-MAY-1 996 15-DEC- 1995 22-OCT.1998 10-MAY-i1999 24-OCT-i1998 16-Jul-99 13-Aug-99 13-Aug-99 17-Jun-98 03-DEC-i1996 23-Apr-99 1 7-Jun-98 03-DEC-1996 23-Nov-99 19-OCT-1998 28-Jul-99 19-OCT-1998 16-Jan-97 30-Jan-96 10-Feb-99 8-Feb-99 8-Feb-99 10 AP000006 Pyrococcus horikoshii 0T3 genomic DNA, 1166001-1485000 nt. position 2006200795 24 Feb 2006 rxa02372 2010 GBHTG3:AC01 1461 100974 AC01 1461 GBHTG3:ACO1 1461 100974 AC01 1461 GB-EST2:AA992021 279 AA992021 GB3_HTG4:AC009273 76175 AC009273 GB_HTG4:AC009273 76175 AC009273 rxa02397 1119 Table 4 (continued) Homo sapiens chromosome 19 clone CIT-H-SPC_429L9. -SEQUENCING IN Homo sapiens PROGRESS 4 ordered pieces.

H-omo sapiens chromosome 19 clone CIT-H-SPC_429L1 SEQUENCING IN Homo sapiens PROGRESS 4 ordered pieces.

ot36c0l.sl Soares -testis NHT Homo sapiens cDNA clone IMAGE:16 18848 Homo sapiens mRNA sequence.

Arabidlopsis thaliana chromosome 1 clone Ti N6, SEQUENCING IN Arabidlopsis thaliana, PROGRESS 2 ordered pieces.

Arabidopsis thaliana chromosome 1 clone T1 N6. SEQUENCING IN Arabidlopsis thaliana PROGRESS 2 ordered pieces.

Ecoli genomic DNA, Kohara clone #335(40.9-41.3 min.). Escherichia coli EST38262 Embryo, 9 week Homo sapiens cDNA 5' end, mRNA sequence. Homo sapiens H-omo sapiens chromosome 17, clone hRPK.214_0_-1, complete sequence. H-omo sapiens Homo sapiens chromosome 17, clone hRPK.2140O1, complete sequence. Homo sapiens B.stearothermophilus Ict gene. Bacillus GBBA1:D90826 rxa02424 723 GB-EST13:AA334108 GBPR3:AC005224 GBPR3:AC005224 rxa02426 1656 GBPAT:A06664 GBPAT:A04115

GBBAI:BACLDHL

19493 275 166687 166687 1350 1361 11361 32870 D90826 AA3341 08 AC005224 AC005224 A06664 stearothermophilus A041 15 B.stearothermophilus recombinant Ict gene. synthetic construct M14788 B.stearothermophilus Ict gene encoding L-lactate dehydrogenase, complete cdls. Bacillus stearotherrnophilus AF0071 01 Streptomyces hygroscopicus putative pteridine-dependent dioxygenase, PIKS Streptomyces modules 1,2,3 and 4, and putative regulatory protein genes, complete cds and hygroscopicus rxa02487 1827 GBBA2:AFOO7I1 GB-BA1 :MTC1364 GBBA2:AF1 19621 rxaOZ2511 780 GB-PR4:AC002470 GBPR4:AC002472 GBE5T34:A1806938 rxa02512 1086 GBBA1:MTCY1A1O GBBA1:MLCL581 GBOV:GGU43396 rxa02527 1452 GB-BA2:AF008220 putative hydroxylase gene, partial cds.

29540 Z93777 Mycobacterium tuberculosis H37Rv complete genome: segment 52/162.

36,138 36,138 41,219 38,566 38,566 39,600 38,603 36,111 33,427 39,936 40,042 40,338 43,298 44,352 43,611 37,971 38,239 38,983 37,407 43,193 38,789 37,395 07-OCT-1 999 07-OCT-1 999 3-Jun-98 12-OCT- 1999 12-OCT-i1999 21-MAR-1 997 21-Apr-97 14-Aug-98 14-Aug-98 29-Jul-93 17-Feb-97 26-Apr-93 13-Jan-98

C)

17-Jun-98 I 28-Apr-99 30-Nov-99 13-Sep-99 7-Jul-99 17-Jun-98 24-Jun-97 18-Jan-96 4-Feb-98 Mycobacterium tuberculosis 15986 235395 147100 118 25949 AF119621 Pseudomonas abietaniphila BKME-9 Diti (ditl), dioxygenase DitA oxygenase Pseudomonas component small subunit (ditA2), dioxygenase DitA oxygenase component large abietaniphila subunit (ditAl), DitH (ditH), DitG (dit[G), DitF (d017), DitR (ditR), DitE (dlitE, DitD) (ditD), aromatic diterpenoid extradiol ring-cleavage dioygenase (ditC), DitB (ditB), and dioxygenase DitA ferredoxin component (ditA3) genes, complete cds; and unknown genes.

AC002470 Homo sapiens Chromosome 22q1 1.2 BAC Clone bi 35h6 In BCRL2-GGT Homo sapiens Region, complete sequence.

AC002472 Homo sapiens Chromosome 22q1 1.2 PAC Clone pn5 In BCRL2-GGT Region, Homo sapiens complete sequence.

A1806938 wf24b07.xI SoaresNFL_T_GBC_Si Homo sapiens cDNA clone Homo sapiens IMAGE:2356501 3'similar to SW:PLZF_-HUMAN 005516 ZINC FINGER PROTEIN PLZF; mRNA sequence..- Z95387 Mycobacterium tuberculosis H37Rv complete genome; segment 117/162. Mycobacterium 36225 Z96801 2738 U43396 220060 AF008220 Mycobacterium Ieprae cosmid L581.

Gallus gallus tropomnyosin receptor kinase A (ctrkA) mRNA, complete cdls.

Bacillus subtilis rrnB-dnaB genomic region.

tuberculosis Mycobacterium leprae Gallus gallus Bacillus subtilis 2006200795 24 Feb 2006 rxa02547 2262 rxa02566 1332 rxaO2571 1152 rxa02578 1227 rxa02581 1983 rxa02582 4953 rxa02583 1671 rxa02599 600 GBBA2:AF008220 GBHTG2:AC005861 GBPL1:AB006530 GBPL1:CNASA GBP~I-:A8006530 GBES132:A1727189 GB-BA1:CGPUTP GBPL2:SPACI3G6 GBBAl :CGU43535 GBEST35:A1857385 GBBA1:CGU43535 GBPL1:AB016871 GB-PL1 :AB025602 GB-IN1 :CELF36H9 GB-BA1 :MTV0O5 GBBAl :MTVOO5 GBBA1:MTVO26 GBBA1:MTCY33B GB-BA1 :SEERYABS GB-BA2:AF1 13605 GBBA1:SC1C2 GBBA1:AB018531 GBBA1:AEMML 220060 AF008220 112369 AC005861 Table 4 (continued) Bacillus subtilis rrnB-dnaB genomic region.

Arabidopsis thaliana clone F231324, **SEQUENCING IN PROGRESS 7344 5729 7344 619 3791 33481 2531 488 2531 79109 55790 35985 37840 37840 23740 29372 2044 1593 42210 4961 2585 unordered pieces.

A8006530 Citrullus lanatus Sat gene for serine acetyltransferase, complete cds and Citrullus lanatus flanking region.

D85624 Citrullus vulgaris serine acetyltransferase (Sat) DNA, complete cds. Citrullus lanatus AB006530 Citrullus lanatus Sat gene for serine acetyltra nsfe rase, complete cds and Citrullus lanatus flanking region.

A1727189 BNLGHi7498 Six-day Cotton fiber Gossypium hirsutum cDNA 5' similar to Gossypium hirsutum (A0020715) KIAA0908 protein (Homo sapiens], mRNA sequence.

Y09163 C.glutamioum pulP gene. Corynebacterium glutamicum Z54308 S.pombe chromosome I cosmid c13G6. Schizosaccharomyces pombe U43535 Corynebacterium glutamicumn mullidrug resistance protein (cmr) gene, complete Corynebacterium cds. glutamicum A1857385 w155e03.xl NCI_-CGAPBrn25 Homo sapiens cDNA clone IMAGE:2428828 Homo sapiens mRNA sequence.

U43535 Corynebacterium glutamicumn multidrug resistance protein (cmr) gene, complete Corynebacterium cds. glutamicum ABO16871 Arabidopsis thaliana genomic DNA, chromosome 5, TAC clone: K161-22, Arabidopsis thaliana complete sequence.

AB025602 Arabidopsis thaliana genomic DNA, chromosome 5, BAC clone:F14A1. complete Arabidopsis thaliana sequence.

AF016668 Caenorhabditis elegans cosmid F36H9. Caenorhabditis elegans AL010186 Mycobacterium tuberculosisl-I37Rv complete genome; segment 51/162. Mycobacterium tuberculosis AL010186 Mycobacterium tuberculosis H37Rv complete genome; segment 51/162. Mycobacterium tuberculosis AL022076 Mycobacterium tuberculosis H37Rv complete genome; segment 157/162. Mycobacterium tuberculosis Z74697 Mycobacterium tuberculosis H37Rv complete genome: segment 127/162. Mycobacterium tuberculosis X62569 S.erythraea eryA gene for 6-deoxyerythronolyde B synthase 11 a 1ll. Saccharopolyspora erythraea AF1 13605 Streptomyces coelicolor propionyl.CoA carboxylase complex B subunit (pccB) Streptomyces coelicolor gene, complete cds.

AL03 1124 Streptomyces coelicolor cosmid 1 C2. Streptomyces coelicolor AB018531 Corynebacterium glutamicum dtsRl and dtsR2 genes, complete cds. Corynebacterium glutamicum X99639 Ralstonia eutropha mmlH, mmll mmlJ genes. Ralstonia eutropha Bacillus subtilis Arabidopsis thaliana 36,218 38,407 35,449 35,449 34,646 35,099 38,562 35,774 41,872 39,139 38,552 34,213 36,461 35.977 38,517 39,173 38,548 46,263 45,053 58,397 52,916 58,809 35,264 4-Feb-98 29-Apr-99 20-Aug-97 6-Feb-99 20-Aug-97 11-Jun-99 8-Sep-97 18-OCT-i1999 9-Apr-97 26-Aug-99 9-Apr-97 20-Nov-99 20-Nov-99 8-Aug-97 17-Jun-98 17-Jun-98 24-Jun-99 17-Jun-98 28-Feb-92 08-DEC-i1999 15-Jan-99 1 9-OCT-i1998 22-Jan-98 2006200795 24 Feb 2006 GB-EST1 5:AA508926 GB-BA1 :AEMML GB-BA1 SYNPOO Table 4 (continued) 422 AA508926 MBAFCWlCO8T3 Brugia malayi adult female cONA (SAW96MLW-B~mAF) Brugia maiayi cDNA clone AFOWi COB mRNA sequence.

2585 X99639 Ralstonia eutropha mmlH, mmli mmlJ genes.

1964 X17439 Synechocystis ndhC, psbG genes for NDH-C, PSII-G and 0RF157.

Brugia malayi 43.377 8-Jul-97 22-Jan-98 10-Feb-99 rxa02634 1734 Raistonia eutropha 41,148 Synechocystis PCC6803 38,145 GBGSS9:AQ101527 184 GBIN1:MNE133341 rxa02638 999 GBBA2:AE001756 GBGSSi2:AQ423878 399 10938 689 GB-HTG2:AC006765 274498 rxa02659 335 GB-EST36:A1900317 436 GBGSSI2:A0342831 683 GBEST36:A1900856 779 rxa02676 1512 GB_1N2:CELBO213 39134 GBGSS1:CNSOOPZB 364 AQ101527 HS_-2265_-Al_-EllMF CIT Approved Human Genomic Sperm Library D Homo Homo sapiens sapiens genomic clone Plate=2265 Col'=2l Row=I, genomic survey sequence.

AJ133341 Melarhaphe neritoides partial caM gene, exons 1-2. Melarhaphe neritoi AE001756 Thermotoga maritima section 68 of 136 of the complete genome. Thermnotoga mariti AQ423878 CITBI-El-2575E20.TF CITBI-El Homo sapiens genomic clone 2575E20, Homo sapiens genomic survey sequence.

AC006765 Caenorhabditis elegans clone Y43H11, **SEQUENCING IN PROGRESS-, 7 Caenorhabditis ele unordered pieces.

A1900317 scO4aO2.yl Gm-c1012 Glycine max cDNA clone GENOME SYSTEMS CLONE Glycine max ID:Gm-cl 012-1 155 5'similar to SW:PRS6 SOLTU P54778 26S PROTEASE REGULATORY SUBUNIT 68 HOMOLOG. mRNA sequence.

AQ342831 RPCl1 1-122KI7.TJ RPCI-1 1 Homo sapiens genomic clone RPCI-i 1-1221<17, Homo sapiens genomic survey sequence.

A1900856 sbg5c11I.yi Gm-cl 012 Glycirie max cDNA clone GENOME SYSTEMS CLONE Glycine max ID: Gm-c1012-429 5' similar to SW:PRS6_SOLTU P54778 26S PROTEASE REGULATORY SUBUNIT 68 H-OMOLOG. mRNA sequence.

AF039050 Caenorhabditis elegans cosmid B0213. Caenorhabditis ele AL085157 Arabidopsis thaliana genome survey sequence SP6 end of BAC FlOD1 1 of IGF Arabidopsis thalian library from strain Columbia of Arabidopsis thaliana, genomic survey sequence.

X61677 Rat ITPR2 gene for type 2 inositol triphosphate receptor. Rattus norvegicus 089728 Mus musculus mRNA for LOK, complete cds. Mus musculus AQ062004 CIT-HSP-2346014.TR CIT-HSP Homo sapiens genomic clone 2346014, Homo sapiens genomic survey sequence.

AQ555818 HS_5230_-BI_-G06SSP6E RPCI-1 1 Human Male BAC Library Homo sapiens Homo sapiens genomic clone Plate=806 Col=1 1 Row=N, genomnic survey sequence.

AJ009736 Drosophila melanogaster Idefix retroelement: gag, pol and env genes, partial. Drosophila melano AC004801 Homo sapiens 12q 13.1 PAC RPCI1-228P16 (Roswell Park Cancer Institute Homo sapiens Human PAC Library) complete sequence.

AC004801 Homo sapiens l2q13.1 PAC RPCI1-228P16 (Roswell Park Cancer Institute Homo sapiens Human PAC Library) complete sequence.

AV132028 AV132028 Mus musculus C578L16J1 11 -day embryo Mus musculus cDNA dlone Mus musculus 2700087F01. mRNA sequence.

AQ240654 CIT-HSP-2385024.TFB.1 CIT-HSP Homo sapiens genomic clone 2385D324, Homo sapiens genomic survey sequence.

AQ309500 CIT-HSP-2384024.TFD CIT-HSP Homo sapiens genomic clone 2384D24, Homo sapiens genomic survey sequence.

38.798 27-Aug-98 gans 39,072 des mna 41,566 06-DEC-1999 34,762 07-MAY-1999 39.063 06-DEC-1 999 GBRO:RNITPR2R rxa02677 882 GBRO:D89728 GBGS58:AQ062004 39,098 40,104 36,451 2-Jun-99 2-Jun-99 23-MAR-i1999 23-Feb-99 10708 5002 362 gans 35,814 .a 38,462 37.543 38,829 36,565 36.534 gaster 36,522 39,341 2-Jun-99

CD

28-Jun-99 21-OCT-1991 7-Feb-99 31 -Jul-98 29-MAY-i1999 19-Jan-99 2-Feb-99 GBG5514:AQ555818 462 rxaO269i 930 GBIN1:DME9736 741 GB-PR4:AC004801 1 93l561 rxa02718 1170 GB-PR4:AC004801 193561 GB-EST34:AV1 32028 258 GB-GSSIO:A0240654 452 GBGSSi 1:AQ309500 576 37,037 2-Feb-99 43,529 40,044 1-Jul-99 30-Sep-98 38,869 22-DEC-1998 2006200795 24 Feb 2006 rxa02749 999 GB_8A2:AF086791 37867 AF086791 GBBA1:SYCSLRB3 GBBA2:AE001 306 rxa02767 906 GBBA2:AF1 26953 GB_BA1:SC15 GBPR3:HS90L6 rxa02792 876 GBBA2:AF099015 GB_BAI:ECOUW93 GBHTG3:AC011361 Table 4 (continued) Zymomonas mobilis strain ZM4 clone 67E 10 carbamoylphosphate synthetase Zymomonas mobilis small subunit (carA), carbamnoylphosphate synthetase large subunit (carB), transcription elongation factor (g reA), enolase (eno), pyruvate dehydrogenase alpha subunit (pdhA), pyruvate dehydrogenase beta subunit (pdliB), ribonuclease H (rnh), homoserine kinase homolog. alcohol dehydrogenase 11 (adhB), and excinuclease ABC subunit A (uvrA) genes.

complete cds; and unknown genes.

Synechocystis sp. PCC6803 complete genome, 19127, 2392729-2538999. Synechocystis sp.

Chlamydia trachomatis section 33 of 87 of the complete genome. Chlamnydia trachoma Coryriebacterium glutamicumn cystathionine gamma-synthase (metB) gene. Corynebacterium complete cds. glutamicum Streptomyces coelicolor cosmid 15. Streptomyces coelic Human DNA sequence from clone 901-6 on chromosome 22q1 1.21-11.23. Homo sapiens Contains an RPL1 5 (60S Ribosomal Protein LiS5) pseudogene, ESTs, STSs and GSSs, complete sequence.

39.024 146271 13316 1638 D64000 AE001 306 AF1 26953 34,573 tis 38,940 100,000 olor 37,486 34,149 4-Nov-98 13-Feb-99 2-Sep-98 110-Sep-99 1 6-Jun-99 23-Nov-99 1-un-99 190837 Z97353 5000 AF099015 338534 U 14003 186148 AC011361 Streptomyces coeticolor strain A3(2) integrase (int). Fe-containing superoxide dismutase 11 (sodF2), Fe uptake system permease (ftrE), and Fe uptake system integral membrane protein (ftrD) genes, complete cds.

Escherichia coli K-12 chromosomal region from 92.8 to 00.1 minutes.

Homo sapiens chromosome 5 clone CIT-HSPC_482N 19, **SEQUENCING IN PROGRESS 69 unordered pieces.

Homo sapiens clone 0J0622E21, complete sequence.

Homo sapiens clone DJ0820A21, complete sequence.

Human DNA sequence from clone 73H14 on chromosome Xq26.3-28, complete sequence.

rxa02794 1197 rxa02809 375 nxa02811 484 GBPR4:AC005998 GBPR4:AC006008 GB3_PR3:HSDJ73H14

GB_RO:MUSSPCTLT

GB_RO:MUSGRC

GB RO:RNU57062 GBGSS6:AQ832862 96556 57554 95556 3172 894 880 476 AC005998 AC006008 AL080272 Streptomyces coelicolor 36.72 1 Escherichia coli 38,787 Homo sapiens 43,577 Homo sapiens 37,298 Homo sapiens 36,638 Homo sapiens 39,726 Mus musculus 47,518 Mus, musculus 44.939 Rattus norvegicus 41,554 Homo sapiens 35,610 Homo sapiens 38,956 17-Apr-96 06-OCT-i1999 M22527 Mouse cytotoxic T lymphocyte-specific serine protease CCPiI gene, complete M18459 Mouse granzyme C serine esterase mRNA, complete cds.

U57062 Rattus norvegicus natural killer cell protease 4 (RNKP-4) mRNA, complete cds.

AQ832862 HS_5261 -A2 -E10-SP6E RPCI-1 1 Human Male BAC Library Homo sapiens genomic clone Plate=837 Col=20 Rowl, genomic: survey sequence.

A0784593 HS_3248_-A2_-F02_-T7C CIT Approved Human Genomic Sperm Library D Homo sapiens genomic clone Plate=3248 Col=4 Row=K. genomic survey sequence.

29-Jul-99 17-Jun-99 23-Nov-99 19-Jan-96 12-Jun-93 31-Jul-96 27-Aug-99 3-Aug-99 23-Apr-99 28-Nov-98 28-Nov-98 GBGSS5:AQ784593 515 GB-GSS13:AQ473140 397 GBEST18:AA696785 316 GB-EST1 8AA696785 316 rxa02836 678 AQ473140 CITBI-E1-2589G6.TF CITBI-El Honmo sapiens genomic clone 2589G6, genomic Homo sapiens 34,761 survey sequence.

AA696785 GM08392.5prime GM Drosophila melanogaster ovary BlueScript Drosophila Drosophila melanogaster 40,604 melanogaster cONA clone GM08392 Sprime. mRNA sequence.

AA696785 GM08392.5prime GM Drosophila melanogaster ovary BlueScript Drosophila Drosophila melanogaster 38,281 melanogaster cDNA clone GM 08392 5prime, mRNA sequence.

rxs03212 1452 GBBA1:CGBETPGEN 2339 X93514 C.glutamicum betP gene.

GBBAI:SC5F2A 40105 AL049587 Streptomyces coelicolor cosmid 5F2A.

Corynebacterium 99,931 glutamicum Streptomyces coelicolor 57.557 A3(2) 8-Sep-97 24-MAY-i1999 2006200795 24 Feb 2006 GBBA2:AF008220 rxs03220 725 GBPL1:CKHUP2 GB _EST38AW0)48153 GBPL1:CKHUP2 Table 4 (continued) 220060 AF008220 Bacillus subtilis rrnB-dnaB genomic region. Bacillus subtilis 2353 X66855 C.kessleri HUP2 mRNA. Chiorella kessleri 383 AW048153 UI-M-BHI-afq-h-05-0-Ul.sl NIH BMAPMS2 Mus musculus cONA clone UI-M- Mus musculus BH1-alq-h-05-0-UI 3, mRNA sequence.

2353 X66855 C.kessleri HUP2 mRNA. Chlorella kessleri 40,000 45,328 41,758 38,106 4-Feb,-987 18-Sep-99 17-Feb-97 -107- Exemplification Example 1: Preparation of total genomic DNA of Corynebacterium glutamicum ATCC 13032 A culture of Corynebacterium glutamicum (ATCC 13032) was grown overnight at 30 0 C with vigorous shaking in BHI medium (Difco). The cells were harvested by centrifugation, the supernatant was discarded and the cells were resuspended in 5 ml buffer-I of the original volume of the culture all indicated volumes have been calculated for 100 ml of culture volume). Composition of buffer-I: 140.34 g/l sucrose, 2.46 g/l MgSO, x 7H 2 O, 10 ml/i KH 2

PO

4 solution (100 g/l, adjusted to pH 6.7 with KOH), 50 ml/l M12 concentrate (10 g/l (NH,) 2

SO

4 1 g/l NaCI, 2 g/l MgSO, x 7H z

O,

0.2 g/1 CaCI 2 0.5 g/1 yeast extract (Difco), 10 ml/1 trace-elements-mix (200 mg/l FeSO, x H 2 O, 10 mg/l ZnSO, x 7 HzO, 3 mg/1 MnCI 2 x 4 HIO, 30 mg/l H 3 BO, 20 mg/1 CoCI, x 6 H 2 0, 1 mg/l NiCI, x 6 H 2 0, 3 mg/1 Na 2 MoO, x 2 HO, 500 mg/1 complexing agent (EDTA or critic acid), 100 ml/1 vitamins-mix (0.2 mg/l biotin, 0.2 mg/l folic acid, mg/1 p-amino benzoic acid, 20 mg/l riboflavin, 40 mg/1 ca-panthothenate, 140 mg/1 nicotinic acid, 40 mg/l pyridoxole hydrochloride, 200 mg/1 myo-inositol). Lysozyme was added to the suspension to a final concentration of 2.5 mg/ml. After an approximately 4 h incubation at 37'C, the cell wall was degraded and the resulting protoplasts are harvested by centrifugation. The pellet was washed once with 5 ml buffer-I and once with 5 ml TE-buffer (10 mM Tris-HCI, 1 mM EDTA, pH The pellet was resuspended in 4 ml TE-buffer and 0.5 ml SDS solution and 0.5 ml NaCI solution (5 M) are added. After adding ofproteinase K to a final concentration of 200 pLg/ml, the suspension is incubated for ca. 18 h at 37 0 C. The DNA was purified by extraction with phenol, phenol-chloroform-isoamylalcohol and chloroformisoamylalcohol using standard procedures. Then, the DNA was precipitated by adding 1/50 volume of 3 M sodium acetate and 2 volumes of ethanol, followed by a 30 min incubation at -20 0 C and a 30 min centrifugation at 12,000 rpm in a high speed centrifuge using a SS34 rotor (Sorvall). The DNA was dissolved in 1 ml TE-buffer containing pg/ml RNaseA and dialysed at 4 0 C against 1000 ml TE-buffer for at least 3 hours.

During this time, the buffer was exchanged 3 times. To aliquots of 0.4 ml of the dialysed DNA solution, 0.4 ml of 2 M LiCI and 0.8 ml of ethanol are added. After a 108min incubation at -20°C, the DNA was collected by centrifugation (13,000 rpm, Biofuge Fresco, Heraeus, Hanau, Germany). The DNA pellet was dissolved in TE-buffer. DNA prepared by this procedure could be used for all purposes, including southern blotting or construction ofgenomic libraries.

Example 2: Construction of genomic libraries in Escherichia coli of Corynebacterium glutamicum ATCC13032.

Using DNA prepared as described in Example 1, cosmid and plasmid libraries were constructed according to known and well established methods (see Sambrook, J. er al.

(1989) "Molecular Cloning A Laboratory Manual", Cold Spring Harbor Laboratory Press, or Ausubel, F.M. et al. (1994) "Current Protocols in Molecular Biology", John Wiley Sons.) Any plasmid or cosmid could be used. Of particular use were the plasmids pBR322 (Sutcliffe, J.G. (1979) Proc. Natl. Acad Sci. USA, 75:3737-3741); pACYC177 (Change Cohen (1978) J. Bacteriol 134:1141-1156), plasmids of the pBS series (pBSSK+, pBSSK- and others; Stratagene, LaJolla, USA), or cosmids as SuperCosl (Stratagene, LaJolla, USA) or Lorist6 (Gibson, Rosenthal A. and Waterson, R.H. (1987) Gene 53:283-286. Gene libraries specifically for use in C. glutamicum may be constructed using plasmid pSL109 (Lee, and A. J. Sinskey (1994) J. Microbiol. Biotechnol. 4: 256-263).

Example 3: DNA Sequencing and Computational Functional Analysis Genomic libraries as described in Example 2 were used for DNA sequencing according to standard methods, in particular by the chain termination method using ABI377 sequencing machines (see Fleischman, R.D. et al. (1995) "Whole-genome Random Sequencing and Assembly of Haemophilus Influenzae Rd., Science, 269:496- 512). Sequencing primers with the following nucleotide sequences were used: GGAAACAGTATGACCATG-3' (SEQ ID No: 677) or 5'-GTAAAACGACGGCCAGT-3' (SEQ ID No: 678).

Example 4: In vivo Mutagenesis In vivo mutagenesis of Corynebacterium glutamicum can be performed by passage of plasmid (or other vector) DNA through E. coli or other microorganisms Bacillus spp. or yeasts such as Saccharomyces cerevisiae) which are impaired in their capabilities to maintain -109the integrity of their genetic information. Typical mutator strains have mutations in the genes for the DNA repair system mutHLS, mutD, mutT, etc.; for reference, see Rupp, W.D.

(1996) DNA repair mechanisms, in: Escherichia coli and Salmonella, p. 2277-2294, ASM: Washington.) Such strains are well known to those of ordinary skill in the art. The use of such strains is illustrated, for example, in Greener, A. and Callahan, M. (1994) Strategies 7: 32-34.

Example 5: DNA Transfer Between Escherichia coli and Corynebacterium glutamicum Several Corynebacterium and Brevibacterium species contain endogenous plasmids (as pHM1519 or pBLl) which replicate autonomously (for review see, e.g., Martin, J.F. et al. (1987) Biotechnology, 5:137-146). Shuttle vectors for Escherichia coli and Corynebacterium glutamicum can be readily constructed by using standard vectors for E. coli (Sambrook, J. et al. (1989), "Molecular Cloning: A Laboratory Manual", Cold Spring Harbor Laboratory Press or Ausubel, F.M. et al. (1994) "Current Protocols in Molecular Biology", John Wiley Sons) to which a origin or replication for and a suitable marker from Corynebacterium glutamicum is added. Such origins of replication are preferably taken from endogenous plasmids isolated from Corynebacterium and Brevibacterium species. Of particular use as transformation markers for these species are genes for kanamycin resistance (such as those derived from the Tn5 or Tn903 transposons) or chloramphenicol (Winnacker, E.L. (1987) "From Genes to Clones Introduction to Gene Technology, VCH, Weinheim). There are numerous examples in the literature of the construction of a wide variety of shuttle vectors which replicate in both E.

coli and C. glutamicum, and which can be used for several purposes, including gene overexpression (for reference, see Yoshihama, M. et al. (1985) J. Bacteriol. 162:591-597, Martin J.F. et al. (1987) Biotechnology, 5:137-146 and Eikmanns, B.J. et al. (1991) Gene, 102:93-98).

Using standard methods, it is possible to clone a gene of interest into one of the shuttle vectors described above and to introduce such a hybrid vectors into strains of Corynebacterium glutamicum. Transformation of C. glutamicum can be achieved by protoplast transformation (Kastsumata, R. et al. (1984) J. Bacteriol. 159306-311), electroporation (Liebl, E. et al. (1989) FEMSMicrobiol. Letters, 53:399-303) and in cases where special vectors are used, also by conjugation (as described e.g. in Schtfer, -110- A et al. (1990) J. Bacteriol. 172:1663-1666). It is also possible to transfer the shuttle vectors for C. glutamicum to E. coli by preparing plasmid DNA from C. glutamicum (using standard methods well-known in the art) and transforming it into E. coli. This transformation step can be performed using standard methods, but it is advantageous to use an Mcr-deficient E. coli strain, such as NM522 (Gough Murray (1983) J. Mol.

Biol. 166:1-19).

Genes may be overexpressed in C. glutamicum strains using plasmids which comprise pCG 1 Patent No. 4,617,267) or fragments thereof, and optionally the gene for kanamycin resistance from TN903 (Grindley, N.D. and Joyce, C.M. (1980) Proc. Natl. Acad Sci. USA 77(12): 7176-7180). In addition, genes may be overexpressed in C. glutamicum strains using plasmid pSL 109 (Lee, and A. J.

Sinskey (1994)J. Microbiol. Biotechnol. 4: 256-263).

Aside from the use of replicative plasmids, gene overexpression can also be achieved by integration into the genome. Genomic integration in C. glutamicum or other Corynebacterium or Brevibacterium species may be accomplished by well-known methods, such as homologous recombination with genomic region(s), restriction endonuclease mediated integration (REMI) (see, DE Patent 19823834), or through the use of transposons. It is also possible to modulate the activity of a gene of interest by modifying the regulatory regions a promoter, a repressor, and/or an enhancer) by sequence modification, insertion, or deletion using site-directed methods (such as homologous recombination) or methods based on random events (such as transposon mutagenesis or REMI). Nucleic acid sequences which function as transcriptional terminators may also be inserted 3' to the coding region of one or more genes of the invention; such terminators are well-known in the art and are described, for example, in Winnacker, E.L. (1987) From Genes to Clones Introduction to Gene Technology. VCH: Weinheim.

Example 6: Assessment of the Expression of the Mutant Protein Observations of the activity of a mutated protein in a transformed host cell rely on the fact that the mutant protein is expressed in a similar fashion and in a similar quantity to that of the wild-type protein. A useful method to ascertain the level of transcription of the mutant gene (an indicator of the amount of mRNA available for translation to the gene -111product) is to perform a Northern blot (for reference see, for example, Ausubel et al.

(1988) Current Protocols in Molecular Biology, Wiley: New York), in which a primer designed to bind to the gene of interest is labeled with a detectable tag (usually radioactive or chemiluminescent), such that when the total RNA of a culture of the organism is extracted, run on gel, transferred to a stable matrix and incubated with this probe, the binding and quantity of binding of the probe indicates the presence and also the quantity ofmRNA for this gene. This information is evidence of the degree of transcription of the mutant gene. Total cellular RNA can be prepared from Corynebacterium glutamicum by several methods, all well-known in the art, such as that described in Bormann, E.R. et al.

(1992) Mol. Microbiol. 6: 317-326.

To assess the presence or relative quantity of protein translated from this mRNA, standard techniques, such as a Western blot, may be employed (see, for example, Ausubel et al. (1988) Current Protocols in Molecular Biology,.Wiley: New York). In this process, total cellular proteins are extracted, separated by gel electrophoresis, transferred to a matrix such as nitrocellulose, and incubated with a probe, such as an antibody, which specifically binds to the desired protein. This probe is generally tagged with a chemiluminescent or colorimetric label which may be readily detected. The presence and quantity of label observed indicates the presence and quantity of the desired mutant protein present in the cell.

Example 7: Growth of Genetically Modified Corynebacterium glutamicum Media and Culture Conditions Genetically modified Corynebacteria are cultured in synthetic or natural growth media. A number of different growth media for Corynebacteria are both well-known and readily available (Lieb et al. (1989) Appl. Microbiol. Biotechnol., 32:205-210; von der Osten et al. (1998) Biotechnology Letters, 11:11-16; Patent DE 4,120,867; Liebl (1992) "The Genus Corynebacterium, in: The Procaryotes, Volume II, Balows, A. et al., eds.

Springer-Verlag). These media consist of one or more carbon sources, nitrogen sources, inorganic salts, vitamins and trace elements. Preferred carbon sources are sugars, such as mono-, di-, or polysaccharides. For example, glucose, fructose, mannose, galactose, ribose, sorbose, ribulose, lactose, maltose, sucrose, raffinose, starch or cellulose serve as very good carbon sources. It is also possible to supply sugar to the media via complex -112compounds such as molasses or other by-products from sugar refinement. It can also be advantageous to supply mixtures of different carbon sources. Other possible carbon sources are alcohols and organic acids, such as methanol, ethanol, acetic acid or lactic acid. Nitrogen sources are usually organic or inorganic nitrogen compounds, or materials which contain these compounds. Exemplary nitrogen sources include ammonia gas or ammonia salts, such as NH,CI or (NH,) 2 SO,, NH 4 OH, nitrates, urea, amino acids or complex nitrogen sources like corn steep liquor, soy bean flour, soy bean protein, yeast extract, meat extract and others.

Inorganic salt compounds which may be included in the media include the chloride-, phosphorous- or sulfate- salts of calcium, magnesium, sodium, cobalt, molybdenum, potassium, manganese, zinc, copper and iron. Chelating compounds can be added to the medium to keep the metal ions in solution. Particularly useful chelating compounds include dihydroxyphenols, like catechol or protocatechuate, or organic acids, such as citric acid. It is typical for the media to also contain other growth factors, such as vitamins or growth promoters, examples of which include biotin, riboflavin, thiamin, folic acid, nicotinic acid, pantothenate and pyridoxin. Growth factors and salts frequently originate from complex media components such as yeast extract, molasses, corn steep liquor and others. The exact composition of the media compounds depends strongly on the immediate experiment and is individually decided for each specific case. Information about media optimization is available in the textbook "Applied Microbiol. Physiology, A Practical Approach (eds. P.M. Rhodes, P.F. Stanbury, IRL Press (1997) pp. 53-73, ISBN 0 19 963577 It is also possible to select growth media from commercial suppliers, like standard 1 (Merck) or BHI (grain heart infusion, DIFCO) or others.

All medium components are sterilized, either by heat (20 minutes at 1.5 bar and 121 or by sterile filtration. The components can either be sterilized together or, if necessary, separately. All media components can be present at the beginning of growth, or they can optionally be added continuously or batchwise.

Culture conditions are defined separately for each experiment. The temperature should be in a range between 15C and 45°C. The temperature can be kept constant or can be altered during the experiment. The pH of the medium should be in the range of 5 to preferably around 7.0, and can be maintained by the addition of buffers to the media.

An exemplary buffer for this purpose is a potassium phosphate buffer. Synthetic buffers 113such as MOPS, HEPES, ACES and others can alternatively or simultaneously be used. It is also possible to maintain a constant culture pH through the addition of NaOH or NH,OH during growth. If complex medium components such as yeast extract are utilized, the necessity for additional buffers may be reduced, due to the fact that many complex compounds have high buffer capacities. If a fermentor is utilized for culturing the microorganisms, the pH can also be controlled using gaseous ammonia.

The incubation time is usually in a range from several hours to several days. This time is selected in order to permit the maximal amount of product to accumulate in the broth. The disclosed growth experiments can be carried out in a variety of vessels, such as microtiter plates, glass tubes, glass flasks or glass or metal fermentors of different sizes.

For screening a large number of clones, the microorganisms should be cultured in microtiter plates, glass tubes or shake flasks, either with or without baffles. Preferably 100 ml shake flasks are used, filled with 10% (by volume) of the required growth medium. The flasks should be shaken on a rotary shaker (amplitude 25 mm) using a speed-range of 100 300 rpm. Evaporation losses can be diminished by the maintenance of a humid atmosphere; alternatively, a mathematical correction for evaporation losses should be performed.

If genetically modified clones are tested, an unmodified control clone or a control clone containing the basic plasmid without any insert should also be tested. The medium is inoculated to an OD 600 of 0.5 1.5 using cells grown on agar plates, such as CM plates g/1 glucose, 2,5 g/l NaCI, 2 g/l urea, 10 g/l polypeptone, 5 g/l yeast extract, 5 g/l meat extract, 22 g/l NaCI, 2 g/l urea, 10 g/1 polypeptone, 5 g/1 yeast extract, 5 g/1 meat extract, 22 g/l agar, pH 6.8 with 2M NaOH) that had been incubated at 30'C. Inoculation of the media is accomplished by either introduction of a saline suspension of C. glutamicum cells from CM plates or addition of a liquid preculture of this bacterium.

Example 8 -In vitro Analysis of the Function of Mutant Proteins The determination of activities and kinetic parameters of enzymes is well established in the art. Experiments to determine the activity of any given altered enzyme must be tailored to the specific activity of the wild-type enzyme, which is well within the ability of one of ordinary skill in the art. Overviews about enzymes in general, as well as specific details concerning structure, kinetics, principles, methods, -114applications and examples for the determination of many enzyme activities may be found, for example, in the following references: Dixon, and Webb, (1979) Enzymes. Longmans: London; Fersht, (1985) Enzyme Structure and Mechanism.

Freeman: New York; Walsh, (1979) Enzymatic Reaction Mechanisms. Freeman: San Francisco; Price, Stevens, L. (1982) Fundamentals of Enzymology. Oxford Univ.

Press: Oxford; Boyer, ed. (1983) The Enzymes, 3 rd ed. Academic Press: New York; Bisswanger, (1994) Enzymkinetik, 2 nd ed. VCH: Weinheim (ISBN 3527300325); Bergmeyer, Bergmeyer, Grafl, eds. (1983-1986) Methods of Enzymatic Analysis, 3 rd ed., vol. I-XII, Verlag Chemie: Weinheim; and Ullmann's Encyclopedia of Industrial Chemistry (1987) vol. A9, "Enzymes". VCH: Weinheim, p.

352-363.

The activity of proteins which bind to DNA can be measured by several wellestablished methods, such as DNA band-shift assays (also called gel retardation assays).

The effect of such proteins on the expression of other molecules can be measured using reporter gene assays (such as that described in Kolmar, H. et al. (1995) EMBO J. 14: 3895-3904 and references cited therein). Reporter gene test systems are well known and established for applications in both pro- and eukaryotic cells, using enzymes such as beta-galactosidase, green fluorescent protein, and several others.

The determination of activity of membrane-transport proteins can be performed according to techniques such as those described in Gennis, R.B. (1989) "Pores, Channels and Transporters", in Biomembranes, Molecular Structure and Function, Springer: Heidelberg, p. 85-137; 199-234; and 270-322.

Example 9: Analysis of Impact of Mutant Protein on the Production of the Desired Product The effect of the genetic modification in C. glutamicum on production of a desired compound (such as an amino acid) can be assessed by growing the modified microorganism under suitable conditions (such as those described above) and analyzing the medium and/or the cellular component for increased production of the desired product an amino acid). Such analysis techniques are well known to one of ordinary skill in the art, and include spectroscopy, thin layer chromatography, staining methods of various kinds, enzymatic and microbiological methods, and analytical 115chromatography such as high performance liquid chromatography (see, for example, Ullman, Encyclopedia of Industrial Chemistry, vol. A2, p. 89-90 and p. 443-613, VCH: Weinheim (1985); Fallon, A. et al., (1987) "Applications of HPLC in Biochemistry" in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17; Rehm et al.

(1993) Biotechnology, vol. 3, Chapter III: "Product recovery and purification", page 469-714, VCH: Weinheim; Belter, P.A. et al. (1988) Bioseparations: downstream processing for biotechnology, John Wiley and Sons; Kennedy, J.F. and Cabral, J.M.S.

(1992) Recovery processes for biological materials, John Wiley and Sons; Shaeiwitz, J.A. and Henry, J.D. (1988) Biochemical separations, in: Ulmann's Encyclopedia of Industrial Chemistry, vol. B3, Chapter 11, page 1-27, VCH: Weinheim; and Dechow, F.J. (1989) Separation and purification techniques in biotechnology, Noyes Publications.) In addition to the measurement of the final product of fermentation, it is also possible to analyze other components of the metabolic pathways utilized for the production of the desired compound, such as intermediates and side-products, to determine the overall efficiency of production of the compound. Analysis methods include measurements of nutrient levels in the medium sugars, hydrocarbons, nitrogen sources, phosphate, and other ions), measurements of biomass composition and growth, analysis of the production of common metabolites of biosynthetic pathways, and measurement of gasses produced during fermentation. Standard methods for these measurements are outlined in Applied Microbial Physiology, A Practical Approach, P.M. Rhodes and P.F. Stanbury, eds., IRL Press, p. 103-129; 131-163; and 165-192 (ISBN: 0199635773) and references cited therein.

Example 10: Purification of the Desired Product from C. glutamicum Culture Recovery of the desired product from the C. glutamicum cells or supernatant of the above-described culture can be performed by various methods well known in the art.

If the desired product is not secreted from the cells, the cells can be harvested from the culture by low-speed centrifugation, the cells can be lysed by standard techniques, such as mechanical force or sonication. The cellular debris is removed by centrifugation, and the supernatant fraction containing the soluble proteins is retained for further purification of the desired compound. If the product is secreted from the C. glutamicum -116cells, then the cells are removed from the culture by low-speed centrifugation, and the supernate fraction is retained for further purification.

The supernatant fraction from either purification method is subjected to chromatography with a suitable resin, in which the desired molecule is either retained on a chromatography resin while many of the impurities in the sample are not, or where the impurities are retained by the resin while the sample is not. Such chromatography steps may be repeated as necessary, using the same or different chromatography resins. One of ordinary skill in the art would be well-versed in the selection of appropriate chromatography resins and in their most efficacious application for a particular molecule to be purified. The purified product may be concentrated by filtration or ultrafiltration, and stored at a temperature at which the stability of the product is maximized.

There are a wide array of purification methods known to the art and the preceding method of purification is not meant to be limiting. Such purification techniques are described, for example, in Bailey, J.E. Ollis, D.F. Biochemical Engineering Fundamentals, McGraw-Hill: New York (1986).

The identity and purity of the isolated compounds may be assessed by techniques standard in the art. These include high-performance liquid chromatography (HPLC), spectroscopic methods, staining methods, thin layer chromatography, NIRS, enzymatic assay, or microbiologically. Such analysis methods are reviewed in: Patek et al. (1994) Appl. Environ. Microbiol. 60: 133-140; Malakhova et al. (1996) Biotekhnologiya 11: 27- 32; and Schmidt et al. (1998) Bioprocess Engineer. 19: 67-70. Ulmann's Encyclopedia of Industrial Chemistry, (1996) vol. A27, VCH: Weinheim, p. 89-90, p. 521-540, p. 540- 547, p. 559-566, 575-581 and p. 581-587; Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley and Sons; Fallon, A. et al.

(1987) Applications of HPLC in Biochemistry in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17.

Example 11: Analysis of the Gene Sequences of the Invention The comparison of sequences and determination of percent homology between two sequences are art-known techniques, and can be accomplished using a mathematical algorithm, such as the algorithm of Karlin and Altschul (1990) Proc. Natl. Acad. Sci.

USA 87:2264-68, modified as in Karlin and Altschul (1993) Proc. Natl. Acad Sci. USA -117- 90:5873-77. Such an algorithm is incorporated into the NBLAST and XBLAST programs (version 2.0) of Altschul, et al. (1990) J. Mol. Biol. 215:403-10. BLAST nucleotide searches can be performed with the NBLAST program, score 100, wordlength 12 to obtain nucleotide sequences homologous to MCT nucleic acid molecules of the invention. BLAST protein searches can be performed with the XBLAST program, score 50, wordlength 3 to obtain amino acid sequences homologous to MCT protein molecules of the invention. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al., (1997) Nucleic Acids Res. 25(17):3389-3402. When utilizing BLAST and Gapped BLAST programs, one of ordinary skill in the art will know how to optimize the parameters of the program XBLAST and NBLAST) for the specific sequence being analyzed.

Another example of a mathematical algorithm utilized for the comparison of sequences is the algorithm of Meyers and Miller ((1988) Comput. Appl. Biosci. 4: 11- 17). Such an algorithm is incorporated into the ALIGN program (version 2.0) which is part of the GCG sequence alignment software package. When utilizing the ALIGN program for comparing amino acid sequences, a PAM 120 weight residue table, a gap length penalty of 12, and a gap penalty of 4 can be used. Additional algorithms for sequence analysis are known in the art, and include ADVANCE and ADAM. described in Torelli and Robotti (1994) Comput. Appl. Biosci. 10:3-5; and FASTA, described in Pearson and Lipman (1988) P.N.A.S. 85:2444-8.

The percent homology between two amino acid sequences can also be accomplished using the GAP program in the GCG software package (available at http://www.gcg.com), using either a Blosum 62 matrix or a PAM250 matrix, and a gap weight of 12, 10, 8, 6, or 4 and a length weight of 2, 3, or 4. The percent homology between two nucleic acid sequences can be accomplished using the GAP program in the GCG software package, using standard parameters, such as a gap weight of 50 and a length weight of 3.

A comparative analysis of the gene sequences of the invention with those present in Genbank has been performed using techniques known in the art (see, Bexevanis and Ouellette, eds. (1998) Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins. John Wiley and Sons: New York). The gene sequences of the invention -118were compared to genes present in Genbank in a three-step process. In a first step, a BLASTN analysis a local alignment analysis) was performed for each of the sequences of the invention against the nucleotide sequences present in Genbank, and the top 500 hits were retained for further analysis. A subsequent FASTA search a combined local and global alignment analysis, in which limited regions of the sequences are aligned) was performed on these 500 hits. Each gene sequence of the invention was subsequently globally aligned to each of the top three FASTA hits, using the GAP program in the GCG software package (using standard parameters). In order to obtain correct results, the length of the sequences extracted from Genbank were adjusted to the length of the query sequences by methods well-known in the art. The results of this analysis are set forth in Table 4. The resulting data is identical to that which would have been obtained had a GAP (global) analysis alone been performed on each of the genes of the invention in comparison with each of the references in Genbank, but required significantly reduced computational time as compared to such a database-wide GAP (global) analysis. Sequences of the invention for which no alignments above the cutoff values were obtained are indicated on Table 4 by the absence of alignment information.

It will further be understood by one of ordinary skill in the art that the GAP alignment homology percentages set forth in Table 4 under the heading homology (GAP)" are listed in the European numerical format, wherein a represents a decimal point. For example, a value of "40,345" in this column represents "40.345%".

Example 12: Construction and Operation of DNA Microarrays The sequences of the invention may additionally be used in the construction and application of DNA microarrays (the design, methodology, and uses of DNA arrays are well known in the art, and are described, for example, in Schena, M. et al. (1995) Science 270: 467-470; Wodicka, L. et al. (1997) Nature Biotechnology 15: 1359-1367; DeSaizieu, A. et al. (1998) Nature Biotechnology 16: 45-48; and DeRisi, J.L. et al.

(1997) Science 278: 680-686).

DNA microarrays are solid or flexible supports consisting of nitrocellulose, nylon, glass, silicone, or other materials. Nucleic acid molecules may be attached to the surface in an ordered manner. After appropriate labeling, other nucleic acids or nucleic acid mixtures can be hybridized to the immobilized nucleic acid molecules, and the label -119may be used to monitor and measure the individual signal intensities of the hybridized molecules at defined regions. This methodology allows the simultaneous quantification of the relative or absolute amount of all or selected nucleic acids in the applied nucleic acid sample or mixture. DNA microarrays, therefore, permit an analysis of the expression of multiple (as many as 6800 or more) nucleic acids in parallel (see, e.g., Schena, M. (1996) BioEssays 18(5): 427-431).

The sequences of the invention may be used to design oligonucleotide primers which are able to amplify defined regions of one or more C. glutamicum genes by a nucleic acid amplification reaction such as the polymerase chain reaction. The choice and design of the 5' or 3' oligonucleotide primers or of appropriate linkers allows the covalent attachment of the resulting PCR products to the surface of a support medium described above (and also described, for example, Schena, M. et al. (1995) Science 270: 467-470).

Nucleic acid microarrays may also be constructed by in situ oligonucleotide synthesis as described by Wodicka, L. et al. (1997) Nature Biotechnology 15: 1359- 1367. By photolithographic methods, precisely defined regions of the matrix are exposed to light. Protective groups which are photolabile are thereby activated and undergo nucleotide addition, whereas regions that are masked from light do not undergo any modification. Subsequent cycles of protection and light activation permit the synthesis of different oligonucleotides at defined positions. Small, defined regions of the genes of the invention may be synthesized on microarrays by solid phase oligonucleotide synthesis.

The nucleic acid molecules of the invention present in a sample or mixture of nucleotides may be hybridized to the microarrays. These nucleic acid molecules can be labeled according to standard methods. In brief, nucleic acid molecules mRNA molecules or DNA molecules) are labeled by the incorporation of isotopically or fluorescently labeled nucleotides, during reverse transcription or DNA synthesis.

Hybridization of labeled nucleic acids to microarrays is described in Schena, M. et al. (1995) supra; Wodicka, L. et al. (1997), supra; and DeSaizieu A. et al. (1998), supra). The detection and quantification of the hybridized molecule are tailored to the specific incorporated label. Radioactive labels can be detected, for example, as 120described in Schena, M. et al. (1995) supra) and fluorescent labels may be detected, for example, by the method of Shalon et al. (1996) Genome Research 6: 639-645).

The application of the sequences of the invention to DNA microarray technology, as described above, permits comparative analyses of different strains of C.

glutamicum or other Corynebacteria. For example, studies of inter-strain variations based on individual transcript profiles and the identification of genes that are important for specific and/or desired strain properties such as pathogenicity, productivity and stress tolerance are facilitated by nucleic acid array methodologies. Also, comparisons of the profile of expression of genes of the invention during the course of a fermentation reaction are possible using nucleic acid array technology.

Example 13: Analysis of the Dynamics of Cellular Protein Populations (Proteomics) The genes, compositions, and methods of the invention may be applied to study the interactions and dynamics of populations of proteins, termed 'proteomics'. Protein populations of interest include, but are not limited to, the total protein population of C.

glutamicum in comparison with the protein populations of other organisms), those proteins which are active under specific environmental or metabolic conditions during fermentation, at high or low temperature, or at high or low pH), or those proteins which are active during specific phases of growth and development.

Protein populations can be analyzed by various well-known techniques, such as gel electrophoresis. Cellular proteins may be obtained, for example, by lysis or extraction, and may be separated from one another using a variety of electrophoretic techniques. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) separates proteins largely on the basis of their molecular weight. Isoelectric focusing polyacrylamide gel electrophoresis (IEF-PAGE) separates proteins by their isoelectric point (which reflects not only the amino acid sequence but also posttranslational modifications of the protein). Another, more preferred method of protein analysis is the consecutive combination of both IEF-PAGE and SDS-PAGE, known as 2-D-gel electrophoresis (described, for example, in Hermann et al. (1998) Electrophoresis 19: 3217-3221; Fountoulakis et al. (1998) Electrophoresis 19: 1193-1202; Langen et al.

(1997) Electrophoresis 18: 1184-1192; Antelmann et al. (1997) Electrophoresis 18: 121 1451-1463). Other separation techniques may also be utilized for protein separation, such as capillary gel electrophoresis; such techniques are well known in the art.

Proteins separated by these methodologies can be visualized by standard techniques, such as by staining or labeling. Suitable stains are known in the art, and include Coomassie Brilliant Blue, silver stain, or fluorescent dyes such as Sypro Ruby (Molecular Probes). The inclusion of radioactively labeled amino acids or other protein precursors 35S-methionine, 35 S-cysteine, 4 C-labelled amino acids, acids, 5 N0 3 or oNH4 or 13C-labelled amino acids) in the medium of C. glutamicum permits the labeling of proteins from these cells prior to their separation. Similarly, fluorescent labels may be employed. These labeled proteins can be extracted, isolated and separated according to the previously described techniques.

Proteins visualized by these techniques can be further analyzed by measuring the amount of dye or label used. The amount of a given protein can be determined quantitatively using, for example, optical methods and can be compared to the amount of other proteins in the same gel or in other gels. Comparisons of proteins on gels can be made, for example, by optical comparison, by spectroscopy, by image scanning and analysis of gels, or through the use of photographic films and screens. Such techniques are well-known in the art.

To determine the identity of any given protein, direct sequencing or other standard techniques may be employed. For example, N- and/or C-terminal amino acid sequencing (such as Edman degradation) may be used, as may mass spectrometry (in particular MALDI or ESI techniques (see, Langen et al. (1997) Electrophoresis 18: 1184-1192)). The protein sequences provided herein can be used for the identification of C. glutamicum proteins by these techniques.

The information obtained by these methods can be used to compare patterns of protein presence, activity, or modification between different samples from various biological conditions different organisms, time points of fermentation, media conditions, or different biotopes, among others). Data obtained from such experiments alone, or in combination with other techniques, can be used for various applications, such as to compare the behavior of various organisms in a given metabolic) situation, to increase the productivity of strains which produce fine chemicals or to increase the efficiency of the production of fine chemicals.

122

EQUIVALENTS

SThose of ordinary skill in the art will recognize, or will be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such equivalents are intended to be encompassed by the following claims.

Comprises/comprising and grammatical variations thereof when used in 0 this specification are to be taken to specify the presence of stated features, NO integers, steps or components or groups thereof, but do not preclude the 0 10 presence or addition of one or more other features, integers, steps, components or groups thereof.

Claims (30)

1. An isolated Corynebacterium glutamicum nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of each of the odd numbered SEQ ID NOs: 7 to 675, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof.

2. An isolated nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence selected from the group consisting of each of the even numbered SEQ ID NOs: 8 to 676, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof.

3. An isolated nucleic acid molecule which encodes a naturally occurring allelic variant of a polypeptide comprising an amino acid sequence selected from the group consisting of each of the even numbered SEQ ID NOs: 8 to 676, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof.

4. An isolated nucleic acid molecule comprising a nucleotide sequence which is at least identical to the entire nucleotide sequence of any of the odd numbered SEQ ID NOs: 7 to 675, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof. An isolated nucleic acid molecule comprising a fragment of at least 15 contiguous nucleotides of the nucleotide sequence of any of the odd numbered SEQ ID NOs: 7 to 675, provided that the nucleic acid molecule does not consist of any of the F- designated genes set forth in Table 1, or a complement thereof.

6. An isolated nucleic acid molecule comprising the nucleic acid molecule of any one of claims 1-5 and a nucleotide sequence encoding a heterologous polypeptide.

7. A vector comprising the nucleic acid molecule of any one of claims 1-6.

8. The vector of claim 7, which is an expression vector.

9. A host cell transfected with the expression vector of claim 8. The host cell of claim 9, wherein said cell is a microorganism.

11. The host cell of claim 10, wherein said cell belongs to the genus Corynebacterium or Brevibacterium.

12. The host cell of claim 9, wherein the expression of said nucleic acid molecule results in the modulation in production of a fine chemical from said cell.

13. The host cell of claim 12, wherein said fine chemical is selected from the group consisting of: organic acids, proteinogenic and nonproteinogenic amino acids, purine and pyrimidine bases, nucleosides, nucleotides, lipids, saturated and unsaturated fatty acids, diols, carbohydrates, aromatic compounds, vitamins, cofactors, polyketides, and enzymes.

14. A method of producing a polypeptide, the method comprising culturing the host cell of claim 9 in an appropriate culture medium to, thereby, produce the polypeptide. An isolated polypeptide comprising an amino acid sequence selected from the group consisting of each of the even numbered SEQ ID NOs: 8 to 676, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1.

16. An isolated polypeptide comprising a naturally occurring allelic variant of a polypeptide comprising an amino acid sequence selected from the group consisting of each of the even numbered SEQ ID NOs: 8 to 676, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1.

17. An isolated polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 50% identical to the entire nucleic acid sequence of any of the odd numbered SEQ ID NOs: 7 to 675, provided that the nucleic acid molecule does not consist of any of the F-designated nucleic acid molecules set forth in Table 1.

18. An isolated polypeptide comprising an amino acid sequence which is at least identical to the entire amino acid sequence of any of the even numbered SEQ ID NOs: 8 to 676, provided that the amino acid sequence is not encoded by any of the F- designated genes set forth in Table 1.

19. An isolated polypeptide comprising a fragment of a polypeptide comprising the amino acid sequence of any of the even numbered SEQ ID NOs: 8 to 676, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1, wherein said polypeptide fragment maintains a biological activity of the polypeptide comprising the amino sequence. The isolated polypeptide of any of claims 15-19, further comprising heterologous amino acid sequences.

21. A method for producing a fine chemical, the method comprising culturing the cell of claim 9 such that the fine chemical is produced.

22. The method of claim 21, wherein said method further comprises the step of recovering the fine chemical from said culture.

23. The method of claim 21, wherein said cell belongs to the genus Corynebacterium or Brevibacterium.

24. The method of claim 21, wherein said cell is selected from the group consisting of: Corynebacteriumn glutamicum, Corynebacterium herculis, Corynebacteriumn, lilium, Corynebacterium acetoacidophilum, Corynebacterium acetoglutamnicumn, Corynebacterium acetophilum, Corynebacterium ammoniagenes, Corynebacterium fujiokense, Corynebacterium nitrilophilus, Brevibacterium ammoniagenes, Brevibacterium butanicum, Brevibacteriumn divaricatum, Brevibacterium flavum, Brevibacterium healii, Brevibacterium ketoglutamicum, Brevibacterium ketosoreductum, Brevibacterium lactofermentum, Brevibacterium linens, Brevibacterium paraffinolyticum, and those strains set forth in Table 3. The method of claim 21, wherein expression of the nucleic acid molecule from said vector results in modulation of production of said fine chemical.

26. The method of claim 21, wherein said fine chemical is selected from the group consisting of: organic acids, proteinogenic and nonproteinogenic amino acids, purine and pyrimidine bases, nucleosides, nucleotides, lipids, saturated and unsaturated fatty acids, diols, carbohydrates, aromatic compounds, vitamins, cofactors, polyketides and enzymes.

27. The method of claim 21, wherein said fine chemical is an amino acid.

28. The method of claim 27, wherein said amino acid is drawn from the group consisting of: lysine, glutamate, glutamine, alanine, aspartate, glycine, serine, threonine, methionine, cysteine, valine, leucine, isoleucine, arginine, proline, histidine, tyrosine, phenylalanine, and tryptophan.

29. A method for producing a fine chemical, comprising culturing a cell whose genomic DNA has been altered by the introduction of a nucleic acid molecule of any one of claims 1-6. A method for diagnosing the presence or activity of Corynebacterium diphtheriae in a subject, the method comprising detecting the presence of at least one of the nucleic acid molecules of any one of claims 1-5 or the polypeptide molecules of any one of claims 15-19, thereby diagnosing the presence or activity of Corynebacterium diphtheriae in the subject.

31. A host cell comprising a nucleic acid molecule selected from the group consisting of each of the odd numbered SEQ ID NOs: 7 to 675, wherein the nucleic acid molecule is disrupted.

32. A host cell comprising a nucleic acid molecule selected from the group consisting of each of the odd numbered SEQ ID NOs: 7 to 675, wherein the nucleic acid molecule comprises one or more nucleic acid modifications as compared to the sequence set forth in any of the odd-numbered SEQ ID NOs: 7 to 675.

33. A host cell comprising a nucleic acid molecule selected from the group consisting of each of the odd numbered SEQ ID NOs: 7 to 675, wherein the regulatory region of the nucleic acid molecule is modified relative to the wild-type regulatory region of the molecule.

34. A polypeptide produced by the method of claim 14. A fine chemical produced by the method of any one of claims 21-29. DATED this 24 th day of February 2006 BASF AKTIENGESELLSCHAFT WATERMARK PATENT TRADE MARK ATTORNEYS 290 BURWOOD ROAD HAWTHORN VICTORIA 3122 AUSTRALIA S QUENCE LISTING <110> BASE' Aktiengesellschaft <120> CORYNEBACTERIUM GLUTAMICUM GENES ENCODING PROTEINS INVOLVED IN MEMBRANE SYNTHESIS AND MEMBRANE TRANS PORT <130> BGI-125CPPC <140> (141> <160> 676 <210> <211> <212> <213> <220> <221> <222> <223> 578 DNA Corynebacterium glutamicum C DS (555) RXN 03097 A <400> 1 att tca Ile Ser 1 gcc agt gca Ala Ser Ala 5 ggt gct ata ggt Gly Ala Ilie Gly tta att tta gaa Leu Ile Leu Glu tat att Tyr Ile ttt aaa aag Phe Lys Lys gga tta gtt Gly Leu Val aca agt tta ctt Thr Ser Leu Leu gga Gi y ctt tta ctc ggt Leu Leu Leu Gly gca tta gca Ala Leu Ala tat ctt agt Tyr Leu Ser gtt att act cct Val Ile Thr Pro g ca Al a gca gga tat gta Ala Gly Tyr Val gca aca Ala Thr ata atg gct tta Ile Met Ala Leu gga ggt atc tgt tgt Gly Gly Ile Cys Cys tat att gtc att Tyr Ile Val Ile aat As n tac atc aaq gta Tyr Ile Lys Vai aaa Lys cta aaa tat cat Leu Lys Tyr His gca tta gat gca Ala Leu Asp Ala 192 240 288 ggt att cat ggt Gly Ile His Gly ggt ggt att att Gly Gly Ile Ilie ggt Gly gct gtt tta aca Ala Val Leu Thr gca gtt Ala Val ttc caa agt Phe Gin Ser act ggt gac Thr Giy Asp 115 aaa gcc aat cct Lys Aia Asn Pro att gag aat ggc Ile Giu Asn Gly ttt att tat Phe Ile Tyr 110 gta aca gca Val Thr Ala ata cat att ata Ile His Ile Ile ctt Leu 120 gta caa ata tta Val Gin Ile Leu t gt Cys 125 gtt gta Val Val 130 att ttt agt atc gtc atg acg ttt att att gcg aaa gta att Ilie Phe Ser Ilie Val Met Thr Phe Ile Ile Ala Lys Val Ile 135 140 aaa Lys 145 tta att aca cca Leu Ilie Thr Pro tct gtt acg gaa Ser Val Thr Giu caa Gln 155 gaa acg aat ata Glu Thr Asn Ile tta gac aag att gtt cac ggt gaa cat got tac ttt gaa ggt gag cta Leu Asp Lys Ile Val His Gly Glu His Ala Tyr Phe Glu Gly Glu Leu 165 170 175 aat aga ttc aat aaa cat att cga tat tagaatatat ttacatagaa Asn Arg Phe Asn Lys His Ile Arg Tyr 180 185 tat <210> 2 (211> 185 <212> PRT <213> Corynebacterium glutamicun <400> 2 Ile Ser Ala Ser Ala Gly Ala 1 Phe Gly Al a Asn Gly The Thr Val1 Lys 145 Leu Asn Lys Leu Thr Tyr Ile Gin Gi y Val1 130 Leu Asp Arg Lys Val1 Ile Ile His Ser Asp 115 Ile Ile Lys Phe Thr Val1 Met Lys Gly Lys 100 Ile Phe Thr Ile Asn 180 5 Thr Ile Ala ValI Val Lys His Ser Pro Val 165 Lys Ser Thr Leu Lys Gly Ala Ile Ile Leu 150 His His Leu Pro Ile 55 Le u Gly As n Ile Val1 135 Ser Gly Ile Ile Gly Leu Gly 25 Ala Ala 40 Gly Gly Lys Tyr Ile Ile Pro Asp 105 Leu Val 120 Met Thr Val Thr Glu His Arg Tyr 185 Trp 10 Leu Gly Ile His Gly 90 Ile Gin Phe Glu Al a 170 Ile Le u Val1 Cys Al a Val1 As n Le u Ile 140 Giu Phe Le u Gly Thr Tyr Leu Leui Gly Cys 125 Ala Thr Glu Glu Ala Tyr Ile Asp Thr Phe 110 Val1 Lys As n Gly Tyr Leu Leu Val1 Ala Ala Ile Thr Val1 Ile Glu 175 <210> 3 <211> 373 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (373) <223> RXA02099 <400> 3 tagttagagc tggttcaagg ggtgtcaatc ccaaaaggca gcttgaeaaa acttcaacgt caaaggaggt catccacgct ctccttgaac tcatgaaaaa atg ggt gca gat caa 11! Met Gly Ala Asp Gin att gca gca gtc Ile Ala Ala Val ggc aat tca gct Gly Asn Ser Ala atg ctg atg tce Met Leu Met Ser gog tcg Ala Ser etc gtg etg Leu Val Leu tct cgt caa Ser Arg Gin cta Leu atg aca cca gca Met Thr Pro Ala ctg be u 30 gca ctt tte tat Ala Leu Phe Tyr ggo ggc atg Gly Gly Met. ttt gga gca Phe Giy Ala aag tcc gtq ctc Lys Ser Val Leu atg atg atg atg Met Met Met Met ttg ggc Leu Gly gte gtt act gtt Val Val Thr Val att Ile 60 tac ctc ttg tgg Tyr Leu Leu Trp gga Gly tgg tog atq tct Trp Ser Met Ser tat Tyr gga acc caa tca Gly Thr Gin Ser gcg gga ate ttt Ala Gly Ile Phe aac ect ttt gag Asn Pro Phe Glu ttc ggt ctt aaa Phe Gly Leu Lys gat tcc Asp Ser <210> 4 <211> 91 <212> PRT <213> Corynebacterium giutamicum <400> 4 Met Giy Ala Asp Gin 1 5 Ile Ala Ala Val Ser 10 Gly Asn Ser Ala Trp Met Leu Met Ser Phe Tyr Gly Ala Ser Leu Val Leu Met Thr Pro Ala Leu Ala Leu Met Met Met Gly Met Ser Arg Lys Ser Val Leu Met Ser Gly Trp Phe Gly Ala Leu Val Val Thr Val Ile Tyr Leu Leu Al a Gly Ile Phe Trp Al a Ser Met Ser T yr 70 Gly Thr Gin Ser Ile 75 Asn Pro Phe Glu Phe Gly Leu Lys Asp Ser <210> (211> <2 12> <213> <220> <221> <222> <223>' 879 DNA Corynebacterium glutamicum C DS (101)..(856) RXA00 104 <400> tgcaaagaca tcccggaacc actccgctac ttqaggtcgg agccatgcct taatqtaacc aaacatctaq aattgagaac aatcgggaaa gaatgctttt atg act gct cag Met Thr Ala Gin 1 gat gat tcg atc Asp Asp Ser Ile ctc Leu acc cat cgt ctc Thr His Arg Leu gcc Ala 15 caa ggc acc gga Gin Gly Thr Giy gaa atc Giu Ile ctc aaa qgt Leu Lys Gly gat gcc ggc Asp Ala Gly gt c Val1 cgc aat gtt ggq Arg Asn Val Gly tta aga ggt cgg Leu Arg Gly Arg aat ctc qgt Asn Leu Gly gtg ttg gag Val Leu Giu 211 259 gac gaa ctc gca Asp Giu Leu Ala agt tgg att gct Ser Trp Ile Ala cag cac Gin His cgc ccc aac gat Arg Pro Asn Asp ttc ctg tct gaa Phie Leu Ser Giu gaa Giu gcc gcc gac aac Ala Ala Asp Asn gac cgc cta tcc Asp Arg Leu Ser aag Lys gac cgc gtg tgg Asp Arq Vai Trp atc gat ccc ctc Ile Asp Pro Leu ga c Asp 307 355 403 ggc acc aaa gaa Cly Thr Lys Giu gcc acc ggc cgc Aia Thr Gly Arq gac tgg gca gta Asp Trp Ala Val cac atc His Ile 100 gca ctg gta Ala Leu Val gac ctt ggc Asp Leu Gly 120 gaa Giu 105 aac ggt gtt ccc Asn Giy Vai Pro acc Thr 110 cac gcc gct gtt His Ala Ala Val ggc ctc ccc Gly Leu Pro 115 gtg act ggc Val Thr Gly 451 499 gtg gtg ttc cac Val Val Phe His gct gat gcc cgc Ala Asp Ala Arg gcc Al a 130 cct tac Pro Tyr 135 tcc aag gtc atc Ser Lys Val Ile atc tcc cac aac Ile Ser His Asn cgc Arg 145 cca cca aag gtt Pro Pro Lys Val cta tct tgc gca Leu Ser Cys Ala cag ctc ggc ttt Gin Leu Gly Phe ga a Glu 160 acc aaq gcc ctt Thr Lys Ala Leu 547 595 643 tcc gca ggc qct Ser Ala Gly Ala a aa L ys 170 gca atg cac gtt Ala Met His Val ctc ggt gac tac Leu Gly Asp Tyr gac gcc Asp Ala 180 tac atc cac gcc ggc ggc caa tac gag tgg gat tcc qca gca cca gtc 691 Tyr Ile His Ala Gly Gly Gin Tyr Glu Trp Asp Ser Ala Ala Pro Val 185 190 195 ggc gtc tgc aag gca gca ggc ttg cac tgc tcc agg ctc gac ggt tcc 739 Gly Val Gys Lys Ala Ala Gly Leu His Cys Ser Arg Leu Asp Gly Ser 200 205 210 gag ctg acc tac aac aac aaa gac acc tac atg cca gac atc ttg atc 787 Glu Leu Thr Tyr Asn Asn Lys Asp Thr Tyr Met Pro Asp Ile Leu Ile 215 220 225 tgt cgc cct gaa ctt gca gat gaa ctt ctc gag atg tgc gcg aag ttc 835 Cys Arq Pro Glu Leu Ala Asp Giu Leu Leu Glu Met Cys Ala Lys Phe 230 235 240 245 tac gag gag aat gga act tac taacgctgtt atgatgacgg cat 879 Tyr Glu Glu Asn Gly Thr Tyr 250 <210> 6 <211> 252 <212> PRT <213> Corynebacterium giutamicum <400> 6 Met Thr Ala Gin Ilie Asp Asp Ser Ile Leu Thr His Arg Leu Ala Gin 1 5 10 Gly Thr Gly Glu Ilie Leu Lys Giy Val Arg Asn Val Gly Val Leu Arg 25 Gly Arg Asn Leu Gly Asp Ala Gly Asp Giu Leu Ala Gin Ser Trp Ile 40 Ala Arg Val Leu Giu Gin His Arg Pro Asn Asp Gly Phe Leu Ser Giu 55 Giu Ala Ala Asp Asn Pro Asp Arg Leu Ser Lys Asp Arg Val Trp Ile 70 75 Ile Asp Pro Leu Asp Gly Thr Lys Glu Phe Ala Thr Gly Arg Gin Asp 90 Trp Ala Val His Ile Ala Leu Val Glu Asn Gly Val Pro Thr His Ala 100 105 110 Ala Val Gly Leu Pro Asp Leu Gly Val Val Phe His Ser Ala Asp Ala 115 120 125 Arg Ala Val Thr Gly Pro Tyr Ser Lys Val Ile Ala Ile Ser His Asn 130 135 140 Arg Pro Pro Lys Val Ala Leu Ser Cys Ala Giu Gin Leu Gly Phe Giu 145 150 155 160 Thr Lys Ala Leu Gly Ser Ala Gly Ala Lys Ala Met His Val Leu Leu 165 170 175 Gly Asp Tyr Asp Ala Tyr Ile His Ala Gly Gly Gin Tyr Glu Trp Asp Ser Ala Ala 195 Arg Leu Asp 210 Pro Val Gly Val Lys Ala Ala Gly His Cys Ser Gly Ser Gin Thr Tyr Asn Asn Lys 220 Asp Thr Tyr Met Pro Asp Ile Len Ile Cys 225 230 Arg Pro Gin Leu Al a 235 Asp Gin Len Len Met Cys Ala Lys Tyr Gin Glu Asn Gly Thr Tyr 250 <210> 7 <211> 8 <212> Di <213> C <220> <221> CI <222> <223> R~ NJA orynebacterium glntamicrr 101)..(859) XA0 14 <400> 7 cgaagttcac gactacaggc attacctggg tgctgatttt gcgcgagtaa agctgtggct gcggaatgcg ctgctcatcc acacgtggaa tcctgattgg gt g Val1 1 acg ctg ggt Thr Len Gly ttg aat gta cca Leu Asn Val Pro tgg tcg ctg ggc Trp Ser Len Gly gaa atg ctg ttc Gin Met Leu Phe tac ctg Tyr Len acg ttc ccg Thr Phe Pro aac tg tgg Asn Trp Trp ct g Len ttt att cog tta The Ile Pro Len gtg Val1 30 cgc aaa gtg aag Arq Lys Val Lys ggc gtg ggc Gly Vai Gly gcg ctg att Ala Leu Ile gca ttt ggc atc Ala Phe Gly Ile ttt goc gtg ago Phe Ala Val Ser aca gtg Thr Val att cac ttt tat le His Phe Tyr gog Al a 60 gao gga cca aag Asp Gly Pro Lys g gg Gly att gag aac tto Ile Gin Asn Phe gtt cot ogo ctg Val Pro Arg Leu gao aco aat gtg Asp Thr Asn Val cog gtc gog gaa Pro Val Ala Gin cac goc gat oca His Ala Asp Pro tgg ttt atg cay Trp Phe Met Gin gaa att ccc gtg Gin Ile Pro Val ctg gaa Leu Gin 100 tot tao tgg Ser Tyr Trp otg Len 105 tot tao tao ttc Ser Tyr Tyr Phe cog Pro 110 ctg acc aga ctc Len Thr Arg Leu atc gag tto Ile Glu Phe 115 tao otc ggt gtg ttt gqc gcg aag ctg gtt got gaa ggc atg ttt aaa Tyr Leu Gly Val Phe Gly Ala Lys Leu Val Ala Glu Gly Met Phe Lys 120 125 130 aac acc aac atc acc: atc ccg ctg atc gca ctg gct gtt tct ttt gtt 547 Asn Thr Asn Ile Thr Ile Pro Leu Ile Ala Leu Ala Val Ser Phe Val 135 140 145 gct act tgg ttt qtq cca ctg gca ttc aag atg tct gtc atc atg tcc 595 Ala Thr Trp Phe Val Pro Leu Ala Phe Lys Met Ser Val Ile Met Ser 150 155 160 165 ctg cca atg gct. ttt gtt qtg gca acg ctt gcg gtg aga gac att gaa 643 Leu Pro Met Ala Phe Val Val Ala Thr Leu Ala Val Arg Asp Ile Giu 170 175 180 ggc aag agt ggg gaa atc gcc tcg cct cgc gca gtt ttq ttq ggt aat 691 Gly Lys Ser Gly Glu Ile Ala Ser Pro Arg Ala Val Leu Leu Gly Asn 185 190 195 att tcc ttt 9CC ttc tac atg gtg caa ttc ccc gtc atg gtg ttt gtg 739 Ile Ser Phe Ala Phe Tyr Met Val Gin Phe Pro Val Met Val Phe Val 200 205 210 cag cgc tat ttc att get gge aaa qaa tac ggc ttc ctt ggc tgg gca 787 Gin Arg Tyr Phe Ile Ala Gly Lys Giu Tyr Gly Phe Leu Gly Trp Ala 215 220 225 ttc tat gca gtg gtg tgt ttc ate gtg tcg gtc att etc gog tgg gtg 835 Phe Tyr Ala Val Val Cys Phe Ile Val Ser Val Ile Leu Ala Trp Val 230 235 240 245 ctg tta cct teg ttg atg atc ctt taataaggcc acggaa 875 Leu Leu Pro Ser Leu Met Ile Leu 250 <210> 8 <211> 253 <212> PRT <213> Corynebacterium glutamicun <400> 8 Val Thr Leu Gly Gly Leu Asn Val Pro Ser Trp Ser Leu Gly Ala Glu 1 5 10 Met Leu Phe Tyr Leu Thr Phe Pro Leu Phe Ile Pro Leu Val Arg Lys 25 Val Lys Gly Val Gly Asn Trp Trp Ala Phe Gly Ile Thr Phe Ala Val 40 Ser Leu Ala Leu Ile Thr Val Ile His Phe Tyr Ala Asp Gly Pro Lys 55 Gly Ile Giu Asn Phe Phe Val Pro Arg Leu Trp Asp Thr Asn Val Ser 70 75 Pro Val Ala Giu Val His Ala Asp Pro Val Trp Phe Met Gin Giu Glu 90 Ile Pro Val Leu Giu Ser Tyr Trp Leu Ser Tyr Tyr Phe Pro Leu Thr Arg Glu Ala 145 Ser Va1 Va1 Va1 Phe 225 Ile Leu Gly 130 Va1 Val Arg Leu Met 210 Leu Leu Ile 115 Met Ser Ile Asp Leu 195 Va1 Gly Ala Phe Lys Va1 Ser 165 Glu Asn Val Ala Val 245 Tyr Asn Ala 150 Leu Gly Ile Gin Phe 230 Leu Leu Thr 135 Thr Pro Lys Ser Arg 215 Tyr Leu Gly 120 Asn Trp Met Ser Phe 200 Tyr Ala Pro 105 Va1 Ile Phe Ala Gly 185 Ala Phe Va1 Ser Phe Thr Va1 Phe 170 Glu Phe Ile Va1 Leu 250 Gly Ile Pro 155 Va1 Ile Tyr Ala Cys 235 Met Ala Pro 140 Leu Va1 Ala Met Gly 220 Phe Ile Lys 125 Leu Ala Ala Ser Va1 205 Lys Ile Leu 110 Leu Ile Phe Thr Pro 190 Gin Glu Va1 Va1 Ala Lys Leu 175 Arg Phe Tyr Ser Ala Leu Met 160 Ala Ala Pro Gly Val 240 <210> 9 <211> 1983 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1960) <223> RXN02581 <400> 9 acggtcactc gctcaagtag tgttagtttq caaaagtaat tggtcacaat agtcattaaa gaattgtaaq aggggttcac gcg Ala ttc Phe gct Ala gaa Glu att Ile cta Leu gaa Glu gac Asp ttc Phe gca Ala ggg Gly gC Gly gat Asp atg Met aaa Lys ctg Leu gga Gly 15 ttc Phe atg Met tac Tyr gaa Glu atg Met cat His acc Thr aaaatqttca tctttgtcga atg gat tta gat aaa Met Asp Leu Asp Lys 1 atc aac ctt cct cca Ile Asn Leu Pro Pro tac cag gct gac atc Tyr Gin Ala Asp Ile ttc tgg qac ttc tcc Phe Trp Asp Phe Ser cga aac gag atc gat Arq Asn Giu Ile Asp act Thr cgt atc aag gct Arg Ile Lys Ala gca ggc cgt ttg Ala Gly Arg Leu cag gtc gcc acc Gln Val Ala Thr ctg Len ggt gat ogt gca Gly Asp Arg Ala atc ctg gct aac Ile Len Ala Asn ago oct gag tac Ser Pro Glu Tyr att tto Ile Phe 100 agc ttc ctc Ser Phe Leu gat cca aac Asp Pro Asn 120 ggc Gly 105 gcg atc tac gct Ala Ile Tyr Ala ggc Gly 110 atg gto cct gtg ccg ott tat Met Val Pro Val Pro Leu Tyr 115 gag cca. gga cac Gin Pro Gly His gac cac cto aac Asp His Leu Asn gtt ttc gca Val Phe Ala gac agc Asp Ser 135 gag cca gtt gto Gin Pro Val Val gtt Val1 140 otg acc aao tcc Leu Thr Asn Ser tcc gca ggt gcc Ser Ala Gly Ala gtg Val 150 ogc aag cac ttc Arg Lys His Phe agc ott cca gct Ser Len Pro Ala, gaa cgc cca cgc Glu Arg Pro Arg atc Ile 165 ctc tot gta gat Leu Ser Val Asp ttg cot gat tot Len Pro Asp Ser oto Leu 175 gcg gat tot tao Ala Asp Ser Tyr gag aac Giu Asn 180 oca atg otg Pro Met Leu gog ccc att Ala Pro Ile 200 acc Thr 185 gaa gco ggo ogo Giu Ala Gly Arg ctg got gct otg Len Ala Ala Leu cgc cag too Arg Gin Ser 195 ggc too aco Gly Ser Thr 691 739 gat ctg aco gca Asp Len Thr Ala tto Phe 205 otg cag tao aco Len Gin Tyr Thr tc Ser 210 cga aco Arg Thr 215 ooa got ggc gtt Pro Ala Gly Val otg aoo aao ogo Len Thr Asn Arg too Se r 225 ato ctg aco aao Ile Len Thr Asn ttg cag atc tto Len Gin Ile Phe gcc gca cag otg Ala Ala Gin Len acc cca ctg cgo Thr Pro Len Arg ctg Len 245 gtt toa tgg otg Val Ser Trp Len otg cao cac gao Len His His Asp a tg Met 255 ggo att ato oto Gly Ile Ile Len gog gog Ala Ala 260 ttt gto act Phe Val Thr tto gtg cag Phe Val Gin 280 atg Met 265 ctt ggc otg gao Len Gly Leu Asp aao Asn 270 gag tto atg aac Gin Phe Met Asn oca ogo gat Pro Arg Asp 275 ogt ogc gaa Arg Arg Gin cag cot toc ogo Gin Pro Ser Arg t gg T rp 285 att aag cag cto Ile Lys Gin Len 931 979 1027 agc gao Ser Asp 295 gtg gao gtt aac Vai Asp Val Asn tao aco gtg gtt Tyr Thr Val Val ct Pro 305 aac tto goo oto Asn Phe Ala Len gag Glu 310 ett gca gca cgc tac gca aag cca gca Leu Ala Ala Arg Tyr Ala Lys Pro Ala 315 gag Glu 320 gqa gag ace ctg Gly Glu Thr Leu ga t Asp 325 1075 ett tee gca ttg Leu Ser Ala Leu gcc atc att atc Ala Ile Ile Ile tee gag cca gtc Ser Glu Pro Val aca gaa Thr Giu 340 1123 aac get ctg Asn Ala Leu gtt cag acc Val Gin Thr 360 ace Thr 345 acc ttc cgt gaa Thr Phe Arg Glu get Ala 350 tte gag ect tac Phe Glu Pro Tyr ggc etg cct Gly Leu Pro 355 tce ctg ctq Ser Leu Leu 1171 1219 ctg cgt cct tce Leu Arg Pro Ser ggt ctt gca gaa Gly Leu Ala Giu gtc acc Val Thr 375 acc cca cag acc Thr Pro Gin Thr gaa Glu 380 aac cgc cca etg Asn Arg Pro Leu ate Ile 385 tcc tac ttc gac Ser Tyr Phe Asp cgc Arg 390 gag gce ttg gc Glu Ala Leu Ala aae ege gtt gag Asn Arg Val Glu gta gaa aag ggc Val Glu Lys Gly 1267 1315 1363 aac aag get gtt Asn Lys Ala Val get Al a 410 ttc qtc tec aac Phe Val Ser Asn gqe Gly 415 eag gtt gca gcc Gin Val Ala Ala cca cag Pro Gin 420 eag ctg gte Gin Leu Val cag ate gge Gin Ile Gly 440 gtt gat tcc gaa Val Asp Ser Giu gga ace gag ctg Gly Thr Giu Leu gca gac ggc Ala Asp Gly 4 gea ggt tae Ala Gly Tyr 1411 1459 gaa ate tgg ace Glu Ile Trp Thr gge gaa aae aet Gly Giu Asn Thr ete gae Leu Asp 455 ege gag gaa gac Arg Giu Giu Asp ace Thr 460 gea gaa ace tte Ala Giu Thr Phe ege Ar g 465 aae egt ctg ace Asn Arg Leu Thr ace Thr 470 ege etg gaa gaa Arg Leu Giu Glu tee ege gea gaa Ser Arg Ala Giu get gee gac gae Ala Ala Asp Asp 1507 1555 1603 tae tgg atg gee Tyr Trp Met Ala ace Thr 490 ggt gae etc gge Gly Asp Leu Gly gte Val1 495 ate gta gae aac Ile Val Asp Asn gag etc Giu Leu 500 tac ate ace Tyr Ile Thr eac tae eca His Tyr Pro 520 egt etg aag gac Arg Leu Lys Asp ate gtt gte gea Ile Val Val Ala gge ega aae Gly Arg Asn 515 tee gca eac Ser Ala His 1651 1699 eag gac ate gag Gin Asp Ile Glu tac Tyr 525 ace gte eag get Thr Val Gin Ala ate egt Ile Arg 535 gca gat tee gte Ala Asp Ser Val gea ttc gca gte Ala Phe Ala Val eca Pro 545 ggc gat gac att Gly Asp Asp Ile 1747 gaa aag ctc atc atc ctg gca Glu Lys Leu Ile Ile Leu Ala 550 555 gac gat gca gct got gaa gaa Asp Asp Ala Ala Ala Glu Glu 570 cac ggt gtt gtt cca gaa gag His Gly Val Val Pro Giu Glu 585 gcg ogt too too too gga aag Ala Arg Ser Ser Ser Gly Lys 600 tac att cag gaa caa got aao Tyr Ile Gln Giu Gin Ala Asn 615 620 <210> <211> 620 <212> PRT <213> Corynebacterium glutat gaa ogo gao aco aot gca aac Glu Arg Asp Thr Thr Ala Asn 560 goa ato ogo too gcc gtt ggc Ala Ile Arg Ser Ala Val Gly 575 atc cgt ato oto: gca Oct gac Ile Arg Ile Leu Ala Pro Asp 590 595 ato goa ogo ogo gto aao oag Ile Ala Arg Arg Val Asn Gin 605 610 tagttotttg oagaoaoogo agg gaa Giu act Thr 580 gag Glu ogo Arg 1795 1843 1891 1939 1983 <400> Met Asp Leu Asp Lys Ala Ile Gly Ser Phe Phe Asp Giu Asn 1 Ile Tyr Phe Arg Gln Pro Pro Asn Lys 145 Glu Asp Gly Glu Le u Aila Asp Giu Ala Tyr Pro 115 Vali Al a Pro Tyr 5 Pro Ile Ser Asp Leu Phe Tyr Al a Al a Ile 165 As n Le u Glu Asp Arg Asp Phe Pro Ser 135 Arg Ser Met Thr Gly 40 Arg Ile Arg Leu As n 120 Glu Lys Val1 Leu Le u Gly Asp Lys Al a Gly 105 Giu Pro His Asp Thr Ala Asp Lys Val1 75 Ile Ile Gly Val Ser 155 Leu Ala Gly Pro Ile Gly Ala Ala Ala 125 Leu Leu Asp Arg Phe Met Tyr Leu Asn Met His Asn Al a Leu 175 Leu Met His Thr Gin Ser Val1 Leu Ser Ala 160 Ala Ala Ala Thr Ser 225 Thr Ile Met Leu Pro 305 Gly Glu Pro Glu Ile 385 Val1 Val1 Glu Thr Arq 465 Al a Val1 Leu Ser 210 Ile Pro Ile Asn Asn 290 As n Giu Pro T yr Ala 370 Ser Glu Ala Leu Al a 450 As n Ala Asp Arg 195 Giy Le u Leu Leu Pro 275 Arg Phe Thr Val1 Gly 355 Ser T yr Lys Al a Al a 435 Ala Arg Asp Asn Gin Se r Thr Arg Al a 260 Arg Arg Al a Leu Thr 340 Leu Leu Phe Giy Pro 420 Asp Gly Leu Asp Giu 500 Se r Thr Asn Leu 245 Al a Asp Giu Leu Asp 325 Glu Pro Leu Asp Asn 405 Gin Gly T yr Thr Asn 485 Leu Pro Thr 215 Leu Ser Val1 Vali Asp 295 Leu Se r Al a Gin Thr 375 Giu Lys Leu Ile Asp 455 Arg T rp Ile Ile 200 Pro Gin Trp Thr Gin 280 Val1 Ala Al a Leu Thr 360 Thr Al a Al a Val1 Gly 440 Arg Leu Met Thr Asp Al a Ile Leu Met 265 Gin As p Al a Leu Thr 345 Leu Pro Leu Val1 Ile 425 Glu Giu Glu Ala Gly 505 Thr Val1 Se r 235 Le u Gly Ser Asn Tyr 315 Al a Phe Pro Thr Giu 395 Phe Asp Trp Asp As n 475 Gly Le u Al a Val1 220 Ala His Leu Arg Val1 300 Ala Ile Arg Ser Giu 380 Asn Val1 Ser Thr Thr 460 Ser Asp Lys Phe 205 Le u Ala His Asp Trp 285 Tyr Lys Ile Giu Tyr 365 As n Arg Ser Giu His 445 Ala Arg Leu Asp Leu Thr Gin Asp As n 270 Ile Thr Pro Ile Ala 350 Gly Arg Val Asn Thr 430 Gly Glu Ala Gly Leu 510 Gin Asn Leu Met 255 Glu Lys Val Ala Gly 335 Phe Leu Pro Giu Gly 415 Gly Glu Thr Giu Val 495 Ile Tyr Arg Lys 240 Gly Phe Gin Val1 Giu 320 Ser Giu Ala Leu Le u 400 Gin Thr As n Phe Gly 480 Ile Val1 Val Ala Gly Arg Asn His Tyr Pro Gin Asp Ile Glu Tyr Thr Val Gin 515 520 525 Ala Ala Ser Ala His Ile Arg Ala Asp Ser Val Ala Ala Phe Ala Val 530 535 540 Pro Gly Asp Asp Ile Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp Thr 545 550 555 560 Thr Ala Asn Glu Ala Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg Ser 565 570 575 Ala Val Gly Thr Ala His Gly Val Val Pro Glu Glu Ile Arg Ile Leu 580 585 590 Ala Pro Asp Glu Ile Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg Arg 595 600 605 Val Asn Gin Arg Asn Tyr Ile Gin Glu Gin Ala Asn 610 615 620 <210> 11 <211> 1550 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1)..(1527) <223> FRXA02581 <400> 11 gtc cct gtg ccg ctt tat gat cca aac gag cca gga cac gca gac cac 48 Val Pro Val Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Ala Asp His 1 5 10 ctc aac gct gtt ttc gca gac agc gag cca gtt gtc gtt ctg acc aac 96 Leu Asn Ala Val Phe Ala Asp Ser Glu Pro Val Val Val Leu Thr Asn 25 tcc aag tec gca ggt gcc gtg cgc aag cac ttc tec age ctt cca gct 144 Ser Lys Ser Ala Gly Ala Val Arg Lys His Phe Ser Ser Leu Pro Ala 40 gca gaa cgc cca cgc ate etc tct gta gat tec ttg cct gat tct ctc 192 Ala Glu Arg Pro Arg Ile Leu Ser Val Asp Ser Leu Pro Asp Ser Leu 55 gcg gat tct tac gag aac cca atg ctg ace gaa gcc ggc cgc cgc ctg 240 Ala Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Ala Gly Arg Arg Leu 70 75 gct get ctg cge cag tec gcg ccc att gat ctg ace gca ttc ctg cag 288 Ala Ala Leu Arg Gin Ser Ala Pro Ile Asp Leu Thr Ala Phe Leu Gin 90 tac ace tec ggc tec ace cga ace cca get ggc gtt gtt ctg ace aac 336 Tyr Thr Ser Gly Ser Thr-Arg Thr Pro Ala Gly Val Val Leu Thr Asn 100 105 110 cgc tcc atc Arg Ser Ile 115 ctg acc aac gtc Leu Thr Asn Vai ttg Leu 120 cag atc ttc agc Gin Ile Phe Ser gca cag ctg Ala Gin Leu aaa acc Lys Thr 130 cca ctg cgc ctg Pro Leu Arg Leu tca tgg ctg cca Ser Trp Leu Pro ct g Leu 140 cac cac gac atg His His Asp Met ggc Gly 145 att atc ctc gcg Ile Ilie Leu Ala ttt qtc act atg Phe Val Thr Met qgc ctg gac aac Gly Leu Asp Asn ttc atg aac cca Phe Met Asn Pro cgc Arg 165 gat ttc gtg cag Asp Phe Vai Gin cag Gin 170 cct tcc cgc tgg Pro Ser Arg Trp att aag Ile Lys 175 cag ctc aac Gin Leu Asn gtt cct aac Val Pro Asn 195 cgc gaa agc gac Arg Giu Ser Asp gac gtt aac gtc Asp Val Asn Val tac acc gtq Tyr Thr Val 190 aag cca gca Lys Pro Ala ttc gcc ctc gag Phe Ala Leu Giu ctt Le u 200 gca gca cgc tac Ala Ala Arg Tyr gca Ala 205 gag gga Giu Gly 210 gag acc ctg gat Giu Thr Leu Asp tcc gca ttg gat Ser Ala Leu Asp gcc Al a 220 atc att atc ggt Ile Ile Ile Gly t cc Se r 225 gag cca qtc aca Giu Pro Val Thr aac gct ctg acc Asn Ala Leu Thr ttc cgt gaa gct Phe Arg Giu Ala 672 720 768 gag cct tac ggc Giu Pro Tyr Gly ct g Leu 245 cct gtt cag acc Pro Val Gin Thr ct g Leu 250 cgt cct tcc tac Arg Pro Ser Tyr ggt ctt Gly Leu 255 gca gaa gca Ala Giu Ala ctg ctg gtc acc Leu Leu Val Thr cca caq acc gaa Pro Gin Thr Giu aac cgc cca Asn Arg Pro 270 cgc gtt gag Arg Val Giu 816 864 ctg atc tcc tac Leu Ile Ser Tyr 275 ttc gac cgc Phe Asp Arg gcc ttg gcc gaa Ala Leu Ala Giu ctt gta Leu Vai 290 gaa aag ggc aat Giu Lys Gly Asn aac Asn 295 aag gct gtt gct Lys Ala Val Ala ttc Phe 300 gtc tcc aac ggc Val Ser Asn Gly cag Gin 305 gtt gca 9CC cca Vai Ala Ala Pro cag ctg gtc atc Gin Leu Val Ile gat tcc gaa acc Asp Ser Giu Thr 912 960 1008 acc gag ctg gca Thr Giu Leu Ala gac Asp 325 ggc cag atc ggc Gly Gin Ile Gly gaa Giu 330 atc tgg acc cac Ile Trp Thr His ggc gaa Gly Giu 335 aac act gct Asn Thr Ala ggt tac ctc gac Gly Tyr Leu Asp gag gaa gac acc Giu Giu Asp Thr gca gaa acc Ala Giu Thr 350 1056 ttc cgc aac cgt ctg acc acc cgc ctg gaa gaa aac tcc cgc gca gaa 1104 Phe Arg Asn Arg Leu Thr Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu 355 360 365 ggt gct gcc gac gac aac tac tgg atg gcc acc ggt gac ctc ggc gtc 1152 Gly Ala Ala Asp Asp Asn Tyr Trp Met Ala Thr Gly Asp Leu Gly Val 370 375 380 ate gta gac aac gag etc tac atc ace ggt cgt ctg aag gac ctc ate 1200 Ile Val Asp Asn Glu Leu Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile 385 390 395 400 gtt gtc gca ggc cga aac cac tac cca cag gac atc gag tac acc gtc 1248 Val Val Ala Gly Arg Asn His Tyr Pro Gin Asp Ile Glu Tyr Thr Val 405 410 415 cag get get tcc gca cac ate cgt gca gat tec gtc gca gca ttc gca 1296 Gin Ala Ala Ser Ala His Ile Arg Ala Asp Ser Val Ala Ala Phe Ala 420 425 430 gtc cca ggc gat gac att gaa aag etc atc atc ctg gca gaa cgc gac 1344 Val Pro Gly Asp Asp Ile Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp 435 440 445 ace act gca aac gaa gcc gac gat gca get get gaa gaa gca ate cgc 1392 Thr Thr Ala Asn Glu Ala Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg 450 455 460 tec gcc gtt ggc act gca cac ggt gtt gtt cca gaa gag ate cgt ate 1440 Ser Ala Val Gly Thr Ala His Gly Val Val Pro Glu Glu Ile Arg Ile 465 470 475 480 ctc gca cct gac gag ate gcg cgt tcc tcc tec gga aag ate gca cgc 1488 Leu Ala Pro Asp Glu Ile Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg 485 490 495 cgc gtc aac'cag cgc aac tac att cag gaa caa get aac tagttctttg 1537 Arg Val Asn Gin Arg Asn Tyr Ile Gin Glu Gin Ala Asn 500 505 cagacaccgc agg 1550 <210> 12 <211> 509 <212> PRT <213> Corynebacterium glutamicum <400> 12 Val Pro Val Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Ala Asp His 1 5 10 Leu Asn Ala Val Phe Ala Asp Ser Glu Pro Val Val Val Leu Thr Asn 25 Ser Lys Ser Ala Gly Ala Val Arg Lys His Phe Ser Ser Leu Pro Ala 40 Ala Glu Arg Pro Arg Ile Leu Ser Val Asp Ser Leu Pro Asp Ser Leu 55 Ala Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Ala Gly Arg Arg Leu 70 75 Ala Ala Leu Arg Gin Ser Ala Pro Ile Asp Leu Thr Ala Phe Leu Gin 90 Tyr Thr Ser Gly Ser Thr Arg Thr Pro Ala Gly Val Val Leu Thr Asn 100 105 110 Arg Ser Ile Leu Thr Asn Val Leu Gin Ile Phe Ser Ala Ala Gin Leu 115 120 125 Lys Thr Pro Leu Arg Leu Val Ser Trp Leu Pro Leu His His Asp Met 130 135 140 Gly Ile Ile Leu Ala Ala Phe Val Thr Met Leu Gly Leu Asp Asn Glu 145 150 155 160 Phe Met Asn Pro Arg Asp Phe Val Gin Gin Pro Ser Arg Trp Ile Lys 165 170 175 Gin Leu Asn Arg Arg Glu Ser Asp Val Asp Val Asn Val Tyr Thr Val 180 185 190 Val Pro Asn Phe Ala Leu Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala 195 200 205 Glu Gly Glu Thr Leu Asp Leu Ser Ala Leu Asp Ala Ile Ile Ile Gly 210 215 220 Ser Glu Pro Val Thr Glu Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe 225 230 235 240 Glu Pro Tyr Gly Leu Pro Val Gin Thr Leu Arg Pro Ser Tyr Gly Leu 245 250 255 Ala Glu Ala Ser Leu Leu Val Thr Thr Pro Gin Thr Glu Asn Arg Pro 260 265 270 Leu Ile Ser Tyr Phe Asp Arg Glu Ala Leu Ala Glu Asn Arg Val Glu 275 280 285 Leu Val Glu Lys Gly Asn Asn Lys Ala Val Ala Phe Val Ser Asn Gly 290 295 300 Gin Val Ala Ala Pro Gin Gin Leu Val Ile Val Asp Ser Glu Thr Gly 305 310 315 320 Thr Glu Leu Ala Asp Gly Gin Ile Gly Glu Ile Trp Thr His Gly Glu 325 330 335 Asn Thr Ala Ala Gly Tyr Leu Asp Arg Glu Glu Asp Thr Ala Glu Thr 340 345 350 Phe Arg Asn Arg Leu Thr Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu 355 360 365 Gly Ala Ala Asp Asp Asn Tyr Trp Met Ala Thr Gly Asp Leu Gly Val 370 375 380 Ile Val Asp Asn Glu Leu Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile 385 Val. Gin Vai Thr Ser 465 Leu Arg Al a Ala Gly 435 Al a Val2 Pro As n Gly Ser 420 Asp Asn Gly Asp Gin 500 Arg 405 Al a Asp Glu Thr Glu 485 Arg 390 As n His Ile Al a Al a 470 Ile Asn Tyr Arg Lys 440 Asp Gly Arg Ile Pro Al a 425 Le u Al a ValI Ser Gin 505 Gin 410 Asp Ile Ala Val1 Ser 490 Glu 395 Asp Ser Ile Al a Pro 475 Ser Gin Giu Ala Ala 445 Glu Giu Lys Asn Thr 415 Phe Arg Ile Arg Ala 495 400 Val1 Al a Asp Arg I le 480 Arg <210> 13 <211> 4953 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(4930) <223> RXA02582 <400> 13 tggatgtcta ttctcctcag cctcgttttg gttgaggcqg agtttaagtt gtaatcgagc tgaaaggctg aggcctcaat t cg Ser gat Asp gac Asp ttg Leu atc Ile cag Gin gtc Val1 atg Met gag Giu gag Glu atg Met acc Thr acc Thr gaa Glu cca Pro 75 gtt Val1 ggt Gly ggc Gi y ct g Leu atc Ile gt t Val gtg Val1 tct Ser acc Thr ttg Le u 80 atagttttaa tattttttta atg gaa cag aqc caa Met Glu Gin Ser Gin 1 cgc acc tgg ctc cgt Arg Thr Trp Leu Arg gag gaa gtt acg gat Glu Giu Val Thr Asp cgc gat gtt gtt gtg Arg Asp Val Val Val tcc ttg gat gcc acc Ser Leu Asp Ala Thr gcg cag cgc ctt gtt Ala Gin Arg Leu Val 115 163 211 259 307 355 gag ggc gag ect Glu Gly Glu Pro egt gca cat acc Arg Ala His Thr cag Gin cgt gaa ttg aat Arg Giu Leu Asn ttc tcc Phe Ser 100 gcg gtg agc Ala Val Ser gct gcg cgt Ala Ala Arg 120 ga t Asp 105 tcc cca ggt tcc Ser Pro Gly Ser gat att gcg gtt Asp Ile Ala Val gtc ggt atg Val Gly Met 115 tgg aag eta Trp Lys Leu tac cca. ggc get Tyr Pro Gly Ala age ctg gag gat Ser Leu Glu Asp atg Met 130 etc gte Leu Val 135 gag ggc cqt gac Glu Gly Arg Asp gg t Gly 140 atc teg gat eta, Ile Ser Asp Leu att. ggc Cgt tgg Ile Gly Arg Trp gag tat gca ggc Glu Tyr Ala Gly gag gtt atg tet Glu Val Met Ser cgg Arg 160 aag atg gaa gag Lys Met Glu Glu tct acc ate ggt Ser Thr Ile GIly ggc Gly 170 tac ctg tca gat Tyr Leu Ser Asp tct. age ttt. gat Ser Ser Phe Asp geg gag Ala Glu 180 ttc ttt ggt Phe Phe Gly cgt att ttg Arg Ile Leu 200 tct ceg ctc gag Ser Pro Leu Giu gec aac atg gat Ala Asn Met Asp ect cag cag Pro Gin Gin 195 get cgc ate Ala Arg Ile etg gag cta aeg Leu Glu Leu Thr gag get ttg gag Glu Ala Leu Glu tae T yr 210 gea cca Ala Pro 215 aae act ttg egt Asn Thr Leu Arg qgc Gly 220 qaa gee gtq gge Glu Ala Val Gly tte ata. ggt tee Phe Ile Gly Ser aae aac gat tac Asn Asn Asp Tyr atg atg ate get Met Met Ile Ala gee Al a 240 gat eea gea gaa Asp Pro Ala Glu cat cet -tat geg His Pro Tyr Ala etg Leu 250 act ggt act tet Thr Gly Thr Ser geg att gte get Ala Ile Val Ala aae ege Asn Arg 260 att aac tae Ile Asn Tyr gca tgt tet Ala Cys Ser 280 tte gat tte ege Phe Asp Phe Arg ect tee gte aae Pro Ser Val Asn gtg gat ace Val Asp Thr 275 egt geg etg Arq Ala Leu tet tet etq gta Ser Ser Leu Val gtt eae cag get Val His Gin Ala gte Val1 290 cgt aat Arg Asn 295 gge gaa geg gat Gly Giu Ala Asp cac His 300 get atc get ggt Ala Ile Ala Gly gg a Gly 305 gtg aae att. ttg Val Asn Ile Leu gca. Ala 310 tet eca ttt gte Ser Pro Phe Val act gca tte get Thr Ala Phe Ala gag Giu 320 etc ggt gtg ate Leu Gly Val Ile 1027 1075 1123 eca ace gge aag ate cae gea tte tet gat gat gee gat ggt tte gtg Pro Thr Gly Lys Pro Tr Gl Lys His Ala Phe Ser As Al ApGy Asp Ala Asp Gly Phe Val 340 cgt tcc gac Arq Ser Asp atc cgc gac Ile Arg Asp 360 ggc Gly 345 gcc qga gtc gtt Ala Gly Val Val gtg Val1 350 ctg aag cgc gtg gat gac gca Leu Lys Arg Val Asp Asp Ala 355 1171 ggc gac aag atc Gly Asp Lys Ile ggt gtg atc aag Gly Val Ile Lys ggt Gly 370 tct gca gtg Ser Ala Val 1219 aac tcc Asn Ser 375 gat ggt cac tcc Asp Gly His Ser gga ctg acc gct Gly Leu Thr Ala aac cct gac gca Asn Pro Asp Ala gtt gat gtg ctg Val Asp Val Leu cag Gin 395 cgt gca tat gtt Arg Ala Tyr Val gac Asp 400 gct cag gtt gat Ala Gin Val Asp 1267 1315 1363 acc acc gtg gat Thr Thr Val Asp gtt gag gct cac Val Glu Ala His acc ggc acc atc Thr Gly Thr Ile ctg ggt Leu Giy 420 gac ccc att Asp Pro Ile gac gca tcc Asp Ala Ser 440 gaa Glu 425 gca act gcc ctg Ala Thr Ala Leu ggt Gly 430 gct gtt ttg ggc Ala Val Leu Gly tat ggc cgt Tyr Gly Arg 435 aac ttc ggc Asn Phe Gly 1411 1459 acc cca act ctt Thr Pro Thr Leu ggc tct gca aag Gly Ser Ala Lys tcc Ser 450 cac act His Thr 455 gag tca gct gcg Glu Ser Ala Ala att gca ggt gtc Ile Ala Gly Val aag gtg ctg ctt Lys Val Leu Leu ttg cag aac aag Leu Gin Asn Lys ctg cca cca acc Leu Pro Pro Thr aac ttt gca ggt Asn Phe Ala Gly cca Pro 485 1507 1555 1603 aac cgc tac atc Asn Arg Tyr Ile gat Asp 490 ttc gat gct gag Phe Asp Ala Glu cgt Arg 495 ttg gaa gtt gtg Leu Glu Val Val gaa gat Giu Asp 500 cca cgt gaa Pro Arg Glu gcg ttc ggg Ala Phe Gly 520 tgg Trp 505 ccg gaa tac aac Pro Giu Tyr Asn ggt Gly 510 cac gca gta qct His Ala Val Ala ggt gtg tct Gly Val Ser 515 tct gag tac Ser Glu Tyr 1651 1699 ttc ggt gga acc Phe Gly Gly Thr aac Asn 525 gcg cac gtg gtg Ala His Val Val aac gca Asn Ala 535 gaa gac tac gaa Giu Asp Tyr Giu cgt gcc ccg aag Arg Ala Pro Lys gag Giu 545 gcg ttg ctt cct Ala Leu Leu Pro 1747 1795 cag cag gtt gcc Gin Gin Val Ala ccg gtg tct ggt Pro Val Ser Gly ctg cca tcc agg Leu Pro Ser Arg cg t Arg 565 cga caa gca gct gct gac ttg gcg gac ttc ttg gag ggc cgc aaa gat Arg Gin Ala Ala Ala Asp Leu Ala Asp Phe Len Glu Gly Arg Lys Asp 1843 570 tgc gac cta Cys Asp Leu cgc tcc cgc Ary Ser Arg 600 cca gta gcc cgc Pro Val Ala Arg ctg gca ggc cgc Leu Ala Gly Arg aat cat ggc Asn His Gly 595 gcc gta aag Ala Val Lys 1891 1939 gca gtc gtg ctt Ala Val Val Leu gca Ala 605 agc act atc gag Ser Thr Ile Giu gaa Giu 610 cgc ctg Arg Leu 615 cgc cag gtc gca Arg Gin Val Ala ggc aag gtc agc Gly Lys Val Ser ggt atc tcc gca Gly Ile Ser Ala gct Al a 630 gat tcc cca gcg Asp Ser Pro Ala aac ggt cct gtg Asn Gly Pro Val ttt Phe 640 gtg tac tcc ggt Vai Tyr Ser Gly ttc Phe 645 1987 2035 2083 gga tcc cag cac Gly Ser Gin His cgc Arg 650 ctc atg atc aag Leu Met Ile Lys ttg tgc tca att Leu Cys Ser Ile tcg cca Ser Pro 660 cag ttc cgc Gin Phe Arg tcc ggc tgg Ser Gly Trp 680 cgc atc gaa gag Arg Ile Giu Giu gat gaa atg gtt Asp Giu Met Val aag ttc gag Lys Phe Glu 675 caa act tac Gin Thr Tyr 2131 2179 tcc atc atg aaa Ser Ile Met Lys ct t Leu 685 gtt ttg gat gat Val Leu Asp Asp gag Giu 690 gac acc Asp Thr 695 gag acc gog cag Glu Thr Ala Gin gtg atc acc qca Val Ile Thr Ala at c Ile 705 cag atc gca ctg Gin Ile Ala Leu act Thr 710 gac ctg ttg gca Asp Leu Leu Ala ttc ggt gta aag Phe Gly Val Lys cca Pro 720 gct gcc gtc atg Ala Ala Val Met ggc Gly 725 2227 2275 2323 atg tcg atg ggt Met Ser Met Gly gag Glu 730 atc gct gcc gct Ile Ala Ala Ala tac T yr 735 gct gcc ggt gga Ala Ala Gly Gly ctc agc Leu Ser 740 gac cgc gat Asp Arg Asp gag ggc gag Glu Giy Giu 760 atg ctc att gcc Met Leu Ile Ala cac cgt tcc cgc His Arg Ser Arg cta atg ggc Leu Met Gly '755 atg gct gtg Met Ala Val 2371 2419 aag tcc ctg gct Lys Ser Leu Ala gag Giu 765 gat cag ctg ggt Asp Gin Leu Gly gtg gaa Val Glu 775 ttc gcc gct gcg Phe Ala Ala Ala gac Asp 780 ctg gat aag ttc Leu Asp Lys Phe atc Ile 785 gaa gaa aac cct Glu Glu Asn Pro gag Glu 790 tac aag ggc att Tyr Lys Gly Ile gag Giu 795 cct gct gtt tat Pro Ala Val Tyr ggc cca ggc atg Gly Pro Gly Met 2467 2515 2563 acc gtg ggt gga Thr Val Gly Gly cgc gac gcc gtg Arg Asp Ala Vai gtt Val 815 cag ttc gta gag Gin Phe Val Giu aag ctg Lys Leu 820 gaa tct gaa Glu Ser Glu cac ace tct His Thr Ser 840 aag ttt gcc oge Lys Phe Ala Arg ctc aac gte aag Leu Asn Val Lys ggc gct ggc Gly Ala Gly 835 ggc gaa atc Gly Giu Ile 2611 2659 get gtg gaa eca Ala Val Giu Pro ctt gqt gag etc Leu Gly Giu Leu get Ala 850 get ggc Ala Gly 855 ate gag eca ett Ile Glu Pro Leu cog Pro 860 otg cag ate ecg Leu Gn Ile Pro tte age tet gte Phe Ser Ser Val ga t Asp 870 eag ggt gtt ace Gin Gly Val Thr eca gtt gga gca Pro Val Gly Ala gt g Val1 880 gte cac gao gee Val His Asp Ala ga t Asp 885 2707 2755 2803 tao atg etc ego Tyr Met Leu Arg tgt Cys 890 ace cge cag too Thr Arg Gin Ser gt g Val1 895 tac ttc eag gae Tyr Phe Gin Asp tec ace Ser Thr 900 gaa got gca Glu Ala Ala aac eca gtt Asn Pro Val 920 get gca ggo eac Ala Ala Gly His ace ttg gtg gaa Thr Leu Val Giu att tee cog Ile Ser Pro 915 ace gtg gge Thr Val Gly 2851 2899 gea etc atg gge Ala Leu Met Gly atg aae ace geg Met Asn Thr Ala ttc Phe 930 aag cot Lys Pro 935 gat gca cag etg Asp Ala Gin Leu etg Leu 940 ttc ago etg aag Phe Ser Leu Lys aaa gte oea gag Lys Val Pro Glu gaa tee etc ogc Glu Ser Leu Arg Ott etg geg aag Leu Leu Ala Lys tao gte aao ggc Tyr Val Asn Gly 2947 2995 3043 aac gtt gat ttc Asn Val Asp Phe geg otg tao ggo Ala Leu Tyr Gly ga a Giu 975 ggt gaa ace ate Gly Giu Thr Ile gat eeg Asp Pro 980 eca cae ate Pro His Ile tee tot ggc Ser Ser Gly 1000 ace Thr 985 tgg aag cae eag Trp Lys His Gin ego Arg 990 ttc tgq act too gea ego oca Phe Trp Thr Ser Ala Arg Pro 995 ggc tte ego gtg aat etg eca Gly Phe Arg Val Asn Leu Pro 1010 3091 3139 goa tee etg gat Ala Ser Leu Asp etg ceg Leu Pro 1005 aac aac act gtg geg ttt Asn Asn Thr Val Ala Phe 1015 tee Ser 102 ace gca gee Thr Ala Ala '0 gaa ctg gca oca toe gea Giu Leu Ala Pro Ser Ala 1025 gte ace oca ggt tee tee Val Thr Pro Gly Ser Ser 1040 31U7 3235 1045 gtg gca ate atg gaa Val Ala Ile Met Glu 1030 gea gee gee atg get Ala Ala Ala Met Ala 1035 gte gao goa gtg Val Asp Ala Val gao Asp 1050 gag ego gao atg otg oca oca age gge gaa ate 3283 Giu Arg Asp Met Leu Pro Pro Ser Gly Glu Ile 1055 1060 acc acc atc gtg act Thr Thr Ile Val Thr 1065 aag att gag gga acc Lys Ile Glu Gly Thr 1080 cgc tcc ttg ggc ggt Arq Ser Leu Gly Gly 1070 acc agc act ctt gtc Thr Ser Thr Leu Val 1085 ttg age ctg tcc gta tac Leu Ser Leu Ser Val Tyr 1075 gec gaa ggt ttc gca gcc Ala Glu Gly Phe Ala Ala 1090 3331 3379 aae cca gga Asn Pro Gly 1095 gga tte aac Gly Phe Asn 1110 ttc gcc gca gca tct Phe Ala Ala Ala Ser 1100 acc gat tac aqc gac Thr Asp Tyr Ser Asp 1115 tee ttc gac ggt cca Ser Phe Asp Gly Pro 1105 cag eca gac cct cgc Gin Pro Asp Pro Arg 1120 gge tac gac Gly Tyr Asp tce gac ctg Ser Asp Leu 3427 3475 1125 cct ttg gac atc gaa gca gtc cgc Pro Leu Asp Ile Glu Ala Val Arg 1130 tgg gac eca gcq Trp Asp Pro Ala 1135 gaa gag cgc atg cgc gcc Glu Glu Arg Met Arg Ala 1145 gat gac etc eca cgc gaa Asp Asp Leu Pro Arg Glu 1160 ate gte tee gaa gca atg Ile Val Ser Glu Ala Met 1150 ctc cca etg att gae etc Leu Pro Leu Ile Asp Leu 1165 ace gaa ace gte Thr Glu Thr Val 1140 ggc tac gac gtg Gly Tyr Asp Val 1155 ggc etc gac tec Gly Leu Asp Ser 1170 3523 3571 3619 etc atg gge Leu Met Gly 1175 atg cgc ate aaa aac cgc ate gaa aat gac ttc cag ate Met Arg Ile Lys Asn Arg Ile Glu Asn Asp Phe Gin Ile 1180 1185 3667 3715 1205 eca eca etc cag gte eaa geg etc cgo gat gca tee gte get gac gtg Pro Pro Leu Gin Val Gin Ala Leu Arg Asp Ala Ser Val Ala Asp Val 1190 1195 1200 gta ate atg Val Ile Met gte gae gee Val Asp Ala gtg gaa aac atg gte get Val Giu Asn Met Val Ala 1210 ggc ege Gly Arg 1215 tcc tet gag Ser Ser Glu acg ctt Thr Leu 1220 3763 ace ccg Thr Pro 1225 cag gtg eca Gin Val Pro get gag Ala Glu 1230 gca gea ggg Ala Ala Gly gag get eaa Glu Ala Gin 1235 3811 get get gag tet tet get tcg Ala Ala Giu Ser Ser Ala Ser 1240 ggc gag Gly Glu 1245 gac gtg cag Asp Val Gin ggc gtt ggc gtt Gly Val Gly Val 1250 3859 gca ceg ega Ala Pro Arg 1255 gat geg tcg Asp Ala Ser gaa cgc Glu Arg 1260 atg gte ttt Met Val Phe ggt act Gly Thr 1265 tgg gca gge Trp Ala Gly 3907 etg act ggc get gcg Leu Thr Gly Ala Ala 1270 gca get ggc gtg ace Ala Ala Gly Val Thr 1275 agc aag ttg eca cag ate 3955 Ser Lys Leu Pro Gin Ile 1280 1285 gat gte gat act gca ace gca att gee gag Asp Val Asp Thr Ala Thr Ala Ile Ala Glu ege etc ace gag cgt tcc Arg Leu Thr Glu Arg Ser 95 1300 4003 1290 125 gga att gaa ate age act gaa cag gtg ttg get gca gaa ace ctc gaa 4051 Gly Ile Giu Ile Ser Thr Giu Gin Val Leu Ala Ala Giu Thr Leu Giu 1305 1310 1315 eca ctg tct qac Pro Leu Ser Asp 1320 ctg gtg cgt gaa ggc Leu~ Val Arg Giu Gly 1325 ctc gaa act gaa gtt cag ggc Leu Glu Thr Giu Val Gin Gly 1330 4099 aac att cgt Asn Ile Arg 1335 gtg ctg cgt gga cgt Val Leu Arq Gly Arg 1340 gca gaa ggc tcc acc Ala Glu Giy Ser Thr 1345 aaq cct gca Lys Pro Ala 4147 gtg ttc Val Phe 1350 atg ttc cac Met Phe His cca gct Pro Ala 1355 ggc ggt tct Gly Gly Ser tcc gtg Ser Val 1360 gtc tac caa cca Val Tyr Gin Pro 4195 1365 4243 cta atg cgt cgt Leu Met Arq Arg ctg cct Leu Pro 1370 gaa gat gtc Giu Asp Val cct gtc Pro Val 1375 tat ggc gtt Tyr Gly Val gag cgt Glu Arg 1380 ctg gaa ggc Leu Giu Gly aag aaq tac Lys Lys Tyr 1400 gat ctc A~sp Leu 1385 gct gac cgc Ala Asp Arg gcg gca Ala Ala 1390 gca tat gtt Ala Tyr Val gat gac atc Asp Asp Ile 1395 4291 4339 tcc gat ggc ttc cca Ser Asp Gly Phe Pro 14( gta Val 05 gtt ttg ggt Val Leu Gly ggc tgg aqc ttc Gly Trp Ser Phe 1410 gyc ggt gcc gtt gcc ttc Gly Gly Ala Val Ala Phe 1415 gag gtt Glu Val 1420 gcc cac caa Ala His Gln ctg gtt Leu Vai 1425 ggc tcc gat Gly Ser Asp 4387 gtt gag gta gct acc gtg gcg ttg ctg gat Val Glu Val Ala Thr Val Ala Leu Leu Asp act gtg Thr Val 1440 cag cct tca aac 4435 Gin Pro Ser Asn 1445 1430 1435 cca gca cca gat Pro Ala Pro Asp acc gct Thr Ala 1450 gag gaa act Glu Glu Thr cgt gca Arg Ala 1455 cgc tgg act Arg Trp Thr cgc tac Arg Tyr 1460 4483 gcg gac ttc Ala Asp Phe qcc aag Ala Lys 1465 aag acc tac Lys Thr Tyr gqc ctt Gly Leu 1470 gat ttc gag Asp Phe Glu gta cct ttt Val Pro Phe 1475 4531 4579 gaa atc ttg qac Glu Ile Leu Asp 1480 acc atc gqt Thr Ile Gly gaa gac Giu Asp 1485 gga atg ctg Gly Met Leu tcc atg atg acc Ser Met Met Thr 1490 gac ttc ctg gcc aac acc qac gcc tcc Asp Phe Leu Ala Asn Thr Asp Ala Ser 1495 1500 gtg ctt gaa cac cag cgc gct tct ttt Val Leu Glu His Gin Arg Ala Ser Phe 1510 1515 gag cac qga ttg tcc gca ggt 4627 Giu His Gly Leu Ser Ala Gly 1505 gtg gac aac cgc atc ctg gct 4675 Val Asp Asn Arg Ile I.eu Ala 1520 1525 aaa ctt aat tt Lys Leu Asn Phe gca gac tgg gcc Ala Asp Trp Ala 1530 aac gtt gaa gcc Asn Val Giu Ala 1535 cct gtc atc ctg Pro Val Ile Leu 1540 4723 ttc cgc gcg gaa cgc atg cat gat gqa gct atc gaa ctt gaa cca aac 4771 Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile Giu Leu Gin Pro Asn 1545 tat gcc aag att Tyr Ala Lys Ile 1560 ttg gaa att gtt Leu Glu Ile Val 1575 cca gaa atc ggc Pro Giu Ile Gly 1590 att tct cgg aag Ile Ser Arg Lys gat A~sp cag Gln aca rhr aat \s n 1610 1550 1555 caa gat gga gga tgg tcc gga att gtc aac Gin Asp Gly Gly Trp Ser Gly Ile Val Asn 1565 1570 ctg aat ggt gac cac ctg gca gtt gtc gat Leu Asn Gly Asp His Leu Ala Val Val Asp 1580 1585 gtc gga gct cat ttg agt cgc cgc att gat Val Gly Ala His Leu Ser Arg Arg Ile Asp 1595 1600 tagtaacgqa gagctgacgg aag 4819 4863 4915 1605 495:3 <210> 14 <211> 1610 <212> PRT <213> Corynebacterium giutamicun <400> 14 Met Glu Gin Ser Gin Ser Ser Asp Gin 1 Arg Giu Arg Ser Ala Glu Ala Asp Pro 145 Lys Thr Glu Asp Le u Gin Leu Val1 Met 130 Ile Met T rp Val Val Asp Arq Asn Val 115 Trp Gly Giu be u Thr Val1 Al a Leu Phe 100 Gi y Lys Arg Giu 5 Arg Asp ValI Thr Val1 Ser Met Leu T rp Phe 165 Asp Asp Le u Ile 70 Giu Al a Al a Le u Ser 150 Ser Trp Lys Ser 55 Ala Gly Val1 Ala Val1 135 Giu Thr Val1 Al a 40 Gly Tyr Giu Ser Arg 120 Giu Tyr Ile Val1 25 Met Glu Giu Pro Asp 105 Tyr Gly Al a Gly Le u 185 Met Thr Thr Giu Pro Ar g Pro Gly Asp Asp 155 Tyr Thr Thr Phe Asn Thr Ala Gly Ala Gly 140 Giu Leu Val Gi y Gly Le u Ile His Ser Glu 125 Ile Val1 Ser Giu Gin Ile -Pro Leu Ser Leu Asp Arg Ser Thr Gin His Asp 110 Ser Leu Ser Asp Met Ser Asp Ile 175 Ser Phe Asp Glu Phe Phe Gly Ser Pro Leu Giu Ala Ala Asn 190 Met Asp Pro Gin Gin Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu 195 Glu Val 225 Asp Ile ValI Ala Gly 305 Le u Al a Arg Lys Pro 385 Ala Gly Leu Lys Ile 465 Asn Giu Val1 Tyr 210 Phe Pro Val1 As n Val1 290 Val Gly Asp Val1 Gly 370 Asn Gin Thr Gly Ser 450 Lys Phe Val1 Ala Ala Ile Ala Ala Val1 275 Arg As n Val1 Gly Asp 355 Ser Pro Val1 Ile Tyr 435 As n Val1 Ala Val1 Gl y Arg Gly Glu As n 260 Asp Ala Ile Ile Phe 340 Asp Ala Asp Asp Leu 420 Gly Phe Leu Gly Giu 500 Val1 Ile Ser Ala 245 Arg Thr Leu Leu Ser 325 Val1 Ala Val1 Ala Pro 405 Gly Arg Gly Leu Pro 485 Asp Ser Ala Ser 230 His Ile Ala Arg Ala 310 Pro Arg Ile As n Gin 390 Thr Asp Asp His Ala 470 Asn Pro Ala Pro 215 As n Pro Asn Cys Asn 295 Se r Thr Ser Arg Se r 375 ValI Thr Pro Ala Thr 455 Leu Arg Arg Phe 200 Asn As n Tyr Tyr Ser 280 Gly Pro Gly Asp Asp 360 Asp Asp Val1 Ile Ser 440 Glu Gin Tyr Glu Gly 205 Thr Asp Al a Ala 265 Ser Glu Phe Lys Gly 345 Gly Gly Val1 Asp Giu 425 Thr Ser Asn Ile Trp 505 Phe Le u Tyr be u 250 Phe Ser Al a Val1 Ile 330 Al a Asp His Leu T yr 410 Ala Pro Al a Lys Asp 490 Pro Gly Arg Gly 235 Thr Asp Leu Asp Thr 315 His Gly Lys Ser Gin 395 Val1 Thr Thr Ala Thr 475 Phe Glu Gly Gly 220 Met Gi y Phe Val1 His 300 Thr Ala Val1 Ile Asn 380 Arg Glu Ala Leu Gly 460 Leu Asp Tyr Thr Glu Met Thr Arg Al a 285 Al a Ala Phe Val1 Ile 365 Gi y Ala Ala Leu Leu 445 I le Pro Ala Asn As n Ala Ile Ser Gly 270 Val1 Ile Phe Se r Val 350 Gly Leu Tyr His Gly 430 Gly Al a Pro Glu Gly 510 Ala Val1 Ala Ser 255 Pro His Ala Ala Asp 335 Le u Val1 Thr Val1 Gly 415 Al a Ser Gly Thr Arg 495 His His Gi y Al a 240 Al a Ser Gin Gly Glu 320 Asp Lys I le Al a Asp 400 Thr Val Al a Val1 ValI 480 Leu Al a Val1 Val1 Gin 545 Leu Gin Gly Gin Val1 625 Val1 Cys Met Asp Ile 705 Ala Ala Ser Gly Ile 785 Gly Phe ValI Ile 530 Al a Pro Gi y Arg Glu 610 Gly Tyr Ser Val1 Gin 690 Gin Al a Gly Arq Al a 770 Gin Pro Val1 L ys 515 Se r Le u Se r Arg As n 595 Al a Ile Se r Ile Lys 675 Gin Ile Val1 Giy Leu 755 Met Glu Gly Giu Gly 835 Gin Len Arg Lys 580 His Val Ser Gly Ser 660 Phe Thr Al a Met Leu 740 Met Ala Asn Met Lys 820 Ala T yr Pro Arg 565 Asp Gly Lys Ala Phe 645 Pro Gin Tyr Len Gly 725 Ser Gly Val1 Pro Thr 805 Len Gly As n Asp 550 Arg Cys Arg Arg Ala 630 Gi y Gin Se r Asp Thr Met Asp Gin Val1 Gin 790 Thr Gin His Al a 535 Gin Gin Asp Ser Len 615 Asp Ser Phe Gly Thr 695 Asp Se r Arg Gly Giu 775 Tyr ValI Ser Thr 520 Glu Gin Ala Len. Arg 600 Arg Ser Gin Arg Trp 680 Giu Len Met Asp Giu 760 Phe Lys Gly Gin Ser 840 Asp Val1 Ala Thr 585 Ala Gin Pro His Giu 665 Ser Thr Len Gly Thr 745 Lys Ala Gly Gly Asp 825 Ala Gin Leu 555 Asp Val1 Val1 Al a Al a 635 Len Ile Met Gin Ser '715 Ile Len Len Al a Gin 795 Ar g Phe Gin Thr 540 Pro Len Al a Leu Gin 620 Asn Met Gin Lys Val1 700 Phe Al a Ile Ala Asp 780 Pro Asp Al a Pro 525 Arg Val1 Ala Arg Ala 605 Gly Gly Ile Gln Len 685 Val1 Gly Ala Al a Gin 765 Len Al a Ala Arg Len 845 Ala Ser Asp Ala 590 Ser Lys Pro Lys Len 670 Val1 Ile Val Al a Ser 750 Asp Asp Val1 Val1 Len 830 Len Pro Gly Phe 575 Len Thr Val1 Val1 Gin 655 Asp Len Thr Lys Tyr 735 His Gin Lys Tyr Val1 815 Len Giy Leu Ala Gly Glu Ile Ala Gly Ile Glu Pro Leu Pro Leu Gln Ile Pro 850 855 860 Leu Phe Ser Ser Val Asp Gin Gly Val Thr Tyr Pro Val Gly Ala Val 865 870 875 880 Val His Asp Ala Asp Tyr Met Leu Arg Cys Thr Arg Gin Ser Val Tyr 885 890 895 Phe Gin Asp Ser Thr Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu 900 905 910 Val Glu Ile Ser Pro Asn Pro Val Ala Leu Met Gly Met Met Asn Thr 915 920 925 Ala Phe Thr Val Gly Lys Pro Asp Ala Gin Leu Leu Phe Ser Leu Lys 930 935 940 Arg Lys Val Pro Glu Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu 945 950 955 960 Tyr Val Asn Gly Ala Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly 965 970 975 Glu Thr Ile Asp Pro Pro His Ile Thr Trp Lys His Gin Arg Phe Trp 980 985 990 Thr Ser Ala Arg Pro Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe 995 1000 1005 Arg Val Asn Leu Pro Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu 1010 1015 1020 Leu Ala Pro Ser Ala Val Ala Ile Met Glu Ala Ala Ala Met Ala Val 1025 1030 1035 1040 Thr Pro Gly Ser Ser Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro 1045 1050 1055 Pro Ser Gly Glu Ile Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu 1060 1065 1070 Ser Leu Ser Val Tyr Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala 1075 1080 1085 Glu Gly Phe Ala Ala Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp 1090 1095 1100 Gly Pro Gly Tyr Asp Gly Phe Asn Thr Asp Tyr Ser Asp Gin Pro Asp 1105 1110 1115 1120 Pro Arg Ser Asp Leu Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro 1125 1130 1135 Ala Thr Glu Thr Val Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala 1140 1145 1150 Met Gly Tyr Asp Val Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp 1155 1160 1165 Leu Gly Leu Asp Ser Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu 1170 1175 1180 Asn Asp Phe Gin Ile Pro Pro Leu Gin Val Gin Ala Leu Arg Asp Ala 1185 1190 1195 1200 Ser Val Ala Asp Val Val Ile Met Val Glu Asn Met Val Ala Gly Arg 1205 1210 1215 Ser Ser Glu Thr Leu Val Asp Ala Thr Pro Gin Val Pro Ala Glu Ala 1220 1225 1230 Ala Gly Glu Ala Gin Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val 1235 1240 1245 Gin Gly Val Gly Val Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe 1250 1255 1260 Gly Thr Trp Ala Gly Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser 1265 1270 1275 1280 Lys Leu Pro Gin Ile Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg 1285 1290 1295 Leu Thr Glu Arg Ser Gly Ile Glu Ile Ser Thr Glu Gin Val Leu Ala 1300 1305 1310 Ala Glu Thr Leu Glu Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu 1315 1320 1325 Thr Glu Val Gin Gly Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly 1330 1335 1340 Ser Thr Lys Pro Ala Val Phe Met Phe His Pro Ala Gly Gly Ser Ser 1345 1350 1355 1360 Val Val Tyr Gin Pro Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val 1365 1370 1375 Tyr Gly Val Glu Arg Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala 1380 1385 1390 Tyr Val Asp Asp Ile Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu 1395 1400 1405 Gly Gly Trp Ser Phe Gly Gly Ala Val Ala Phe Glu Val Ala His Gin 1410 1415 1420 Leu Val Gly Ser Asp Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr 1425 1430 1435 1440 Val Gin Pro Ser Asn Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala 1445 1450 1455 Arg Trp Thr Arg Tyr Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp 1460 1465 1470 Phe Glu Val Pro Phe Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met 1475 1480 1485 Leu Ser Met Met Thr Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His 1490 1495 1500 Gly Leu Ser Ala Gly Val Leu Glu His Gln Arg Ala Ser Phe Val Asp 1505 1510 1515 1520 Asn Arg Ile Leu Ala Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu 1525 1530 1535 Ala Pro Val Ile Leu Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile 1540 1545 1550 Giu Leu Glu Pro Asn Tyr Ala Lys Ile Asp Gin Asp Gly Gly Trp Ser 1555 1560 1565 Gly Ilie Val Asn Asp Leu Giu Ile Val Gln Leu Asn Gly Asp His Leu 1570 1575 1580 Ala Val Val Asp Giu Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser 1585 1590 1595 1600 Arg Arg Ile Asp Giu Ile Ser Arg Lys Asn 1605 1610 <210> <211> 540 <212> DNA <213> Coryriebacterium giutamicum <220> <221> CDS <222> (101)..(517) <223> RXA01138 <400> cttattcaag tttttggaaa gataattaac tatgact qctqcqagac actgtcggat cgttcccttc aggtgtc ga t Asp t cg Ser gtt Val t cg Ser aac Asnr g qg Gly ttg Leu gtg Val gaa Giu aaa Lys gtg ValI cct Pro ttt Phe cag Gin ga c Asp qac Asp gcc Ala ttg Leu aqc Ser gqC Gly ggg Gly gt g Val1 cag Gin ttg Leu 60 tcc Ser act Thr gtg Val1 30 tca Ser atc Ile aag Lys ~tta aaaacagtaa acggaacqca :acg gtg gtc acc act acc Val Val Thr Thr Thr 1 agt gcq ttc gtg tcc ttg Ser Ala Phe Val Ser Leu atc gat aag aaa tca agc Ile Asp Lys Lys Ser Ser gtt gct gtg tct gtg tta Val Ala Val Ser Val Leu ttt ggc cqt cat ctq gaa Phe Gly Arg His Leu Glu tca aca aac agg gca gcq Ser.Thr Asn Arg Ala Ala 80 gtc ttg Val Leu tac cca Tyr Pro gct cac Ala His gaa Giu ggt Giy gac Asp 120 tca gca tgg ttg agt ggc gct gtg gtg gat aaa. Ser Ala Trp Leu Ser Gly Ala Val Val Asp Lys 1.00 cac ttt att atc acc att gcc gtg gaa, gag tgt His Phe Ile Ile Thr Ile Ala Val Giu Glu Cys 110 115 caa aag cca, ctt ctt tac cac cqt ggc agg ctt Gin Lys Pro Leu Leu Tyr His Arg Gly Arg Leu 125 130 gat taattctcca. ccccttcatt ttc Asp ttt cag tgg caa gaa Phe Gin Trp Gin Giu 135 <210> 16 <211> 139 <212> PRT <213> Corynebacterium giutamicum <400> 16 Val Vai Thr Thr Thr Asp Gil' Giu Vai 1 Ala Asp Ala Gly Thr Al a Ala His Phe Lys Val1 Arg Asn Val1 Val1 Arg 130 Val1 Lys Ser His Arg Val1 Glu 115 Gly Se r Val1 Ser As n 70 Val1 T yr Al a Phe Giu Pro 40 Gi u Phe Glu Gly Asp 120 Trp Pro Phe Gin Asp Gly Gly 105 Glu Gin Asp 10 Al a Le u Ser Gly Al a Asp Glu Glu His Gly Leu Thr Val Ser Leu Gly Ala Ile T rp Ile Pro 125 Val1 Ser Ile Lys Leu Ile 110 Leu Ser Pro Thr Arg Ser Thr Leu Ile Val Phe Ser Gly Ile Tyr <210> 17 <211> 756 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(733) <223> RXA01980 <400> 2.7 aggatcgtac caaataaggc aataaactct ttttactttt gccgccctag aattcactaa gtttccgata tctttaaccc cctcaacttc ctgaaaagtc atg cag atc att gat 11: Met Gin Ile Ile Asp ctc tct cat gcg Leu Ser His Ala ttc Phe gcg ccc gga caa Ala Pro Giy Gin ccc Pro 15 cac tac cct ggg His Tyr Pro Giy gat cca Asp Pro gat caa gaa Asp Gin Glu atg cat caa Met His Gin aag acg gtc tcc Lys Thr Val Ser att gaa aac gat Ile Giu Asn Asp ggc ttt tta Gly Phe Leu gta gat gca Val Asp Ala tac aga ctt gtt Tyr Arg Leu Val gg t Gi y 45 ccc tgg gga acg Pro Trp Gly Thr cat His cct gca Pro Ala cat ttc gat cca His Phe Asp Pro caa Gin ggt cgg acg ctt Gly Arg Thr Leu cag atc cct gtg Gin Ile Pro Val gag Giu gaa acg cat tta. Giu Thr His Leu ctt tat tgc ctg Leu Tyr Cys Leu ttt tct cgc ccc Phe Ser Arg Pro cta tgt act gct Leu Cys Thr Ala gat ata gaa gcg Asp Ile Giu Ala gaa cat aca cac Glu His Thr His ggg aaa Gly Lys 100 atc gaa. cca Ile Glu Pro aaa caa ggg Lys Gin Gly 120 tcc ttc gtc gca Ser Phe Val Ala cac act gga tg His Thr Gly Trp gaa tgg ggt Glu Trp Giy 115 gaa. atc ctc Giu Ile Leu 451 499 atc gca ccc ggc Ile Ala Pro Gly tct atc gag gct Ser Ile Giu Ala cat gcc His Ala 135 cgt gga gtc att Arg Gly Val Ile gcc Ala 140 att qgc cac gat Ile Gly His Asp ct t Leu 145 ccc gat aca gat Pro Asp Thr Asp cct Pro 150 tca ctg gag gca Ser Leu Glu Ala cgc tgg tgg ctg Arg Trp Trp Leu cgt gac cat tgg Arg Asp His Trp 547 595 643 att gaa aac ctc Ile Giu Asn Leu acc Thr 170 aat ttg gac aag Asn Leu Asp Lys gt t Val1 175 cct gca. acg ggt Pro Ala Thr Giy gcg atg Ala Met 180 att gct tgt Ile Ala Cys cgt cca att Arg Pro Ile 200 tgg cca, gtt cca Trp Pro Val Pro gat ggt gct agt Asp Gly Ala Ser ttc cca gtg Phe Pro Vai 195 gct ctc gtc cca Ala Leu Val Pro cac cta tcc cct His Leu Ser Pro act cgc Thr Arg 210 taaagcgaac ggcagcacct tct <210> 18 <211> 211 <212> PRT <213> Corynebacterium giutarnicum <400> 18 Met Gin Ile Ile 1 T yr As n Thr Asp Phe His Gly Ala Leu 145 Arg Ala Ala Pro Gly Gly Val I le Arg His Glu 115 Giu Asp His Gly Phe 195 Arg Asp Phe Asp Pro Pro Gly 100 Trp Ile Thr Trp Al a 180 Pro Asp 5 Pro Leu Ala Val1 Asp Lys Gly Leu Asp Gin 165 Met Val1 Leu Asp Met Pro Glu 70 Leu Ile Lys His Pro 150 Ile Ile Arg Ser His Ala Gin Giu Ile 25 His Gln Tyr 40 Ala His Phe Glu Thr His Cys Thr Ala Glu Pro Gly 105 Gin Gly Ile 120 Ala Arg Gly 135 Ser Leu Glu Giu Asn Leu Ala Cys Pro 185 Pro Ile Ala 200 Phe Lys Arg Asp Leu Ala Ser Ala Val Ala Thr 170 Trp Leu Al a Thr Leu Pro Pro 75 Asp Phe Pro Ile Gin 155 As n Pro Val1 Gly Ser Gly Gly Tyr Glu Ala Trp 125 Ile Trp Asp Pro Giu 205 Gin Thr Pro Arg Cys Ala Leu 110 Ser GI y Trp Lys Lys 190 His His Glu Gly Leu Arg Giu Thr Glu Asp Cys 160 Pro Gly Ser <210> 19 <211> 1830 <212> DNA <213> <220> <221> <222> <223>' <400> Corynebacterium glutamicum CDS (101)..(1807) RXN 01007 19 tctgaaeeaa tataccgatc agtetaaaag tgtgttaagt tctggaacat aaattagctg acacgtaaag taacttaaag attcactgga ggtaagccta gtg ttt aaa aag Val Phe Lys Lys 1 cac His aga cac ggt etc Arg His Gly Leu ggc Gly tee ccc gaa acc Ser Pro Giu Thr aaa Lys 15 cca egc tca ata Pro Arg Ser Ile ace cgC Thr Arg cgg ttt ttC Arg Phe Phe tcc ggc tgc Ser Gly Cys geg gcC gcc get Ala Ala Ala Ala ctg gca gga ttg gca gtc ctg Leu Ala Gly Leu Ala Val Leu aca gca caa ccc Thr Ala Gin Pro tea Ser 45 eaa gca gaa gac Gin Ala Giu Asp aac As n aeg etc act Thr Leu Thr tac tta Tyr Leu gag eea eag tte Giu Pro Gin Phe eqc ace cig tac Arg Thr Leu Tyr eca tea geg ggc Pro Ser Ala Gly tae eec aae gqe Tyr Pro Asn Gly gtg gtg aae aae Val Val Asn Asn att Ile gea gae ege ttg Ala Asp Arg Leu etc Leu tac cag gat ect Tyr Gin Asp Pro ga a Giu ace ttg gaa etc Thr Leu Glu Leu ceg tgg ate gee Pro Trp Ile Ala aec gaa Thr Glu 100 etc eca gaa Leu Pro Glu ace gat gte Thr Asp Val 120 aac gaa gae gee Asn Glu Asp Ala gaa ttt ace tte Giu Phe Thr Phe aae ate ege Asn Ile Arg 115 gaa aac gtg Glu Asn Val 451 499 ace tac tee gat Thr Tyr Ser Asp g ge Gly 125 ace ceg ctg aeg Thr Pro Leu Thr get Al a 130 gtg aaa Val Lys 135 aae tte gat etc Asn Phe Asp Leu gg cetc ggc qat Gly Leu Gly Asp gat ega ege etc: Asp Arg Arg Leu ate tet gag eag Ile Ser Glu Gin ace aac tac gac Thr Asn Tyr Asp gge gaa gta gta Gly Glu Val Val ga t Asp 165 547 595 643 gag gac ace gte Glu Asp Thr Val ttc cac: ttc tet Phe His Phe Ser gag Giu 175 cet gca ect ggt Pro Ala Pro Gly ttt get Phe Ala 180 eag gee ace Gin Ala Thr gag ttc gee Glu Phe Ala 200 age Ser 185 tee tte aae get Ser Phe Asn Ala gge Gly 190 ctt tat gee gat Leu Tyr Ala Asp tee ace ttg Ser Thr Leu 195 aac gte ate: Asn Val Ile aat gag gat ttc Asn Glu Asp Phe eca ggc aae gee Pro Gly Asn Ala ggc tee Gly Ser 215 ggt cet ttc gtg Gly Pro Phe Val ate Ile 220 aec gat gaa ace Thr Asp Glu Thr eta Leu 225 ge ace aac etc Gly Thr Asn Leu aco Thr 230 cat His gaa Glu gCC Al a atc Ile ttc Phe 310 ct g Leu ga t Asp tac Tyr gct Ala cgc Arg 390 cag Gin gat Asp gac Asp gtg Val1 ttg Leu caa Gin gaa Giu cgc Arg ccg Pro 295 cgc Arg atc Ile tCC Ser aaa Lys ctg Leu 375 aag Lys cct Pro ctg Leu gct Ala ggt Gly 455 act Thr gg t Gly t cc Se r cag Gin 280 atc Ile ttc Phe cac His tat Tyr gaa Glu 360 ctt Leu gac Asp cgt Arg ggc Gly gac Asp 440 cgc Arq qcq Al a cgc Arg gt c ValI 265 atc Ile atc Ile aaa Lys gcg Al a ccg Pro 34S caa Gin gac Asp ggt Gly tca Ser atc Ile 425 tcc Ser gca Ala cg t Arg gcg Ala 250 cgc Arg gaa Giu t cc Ser aac Asn atc Ile 330 ctg Leu gta Val1 gaa Glu gaa Glu CgC Arg 410 aag Lys aag Lys gac Asp gag Giu 235 aag Lys atc I le gcg Ala gca Al a gag Glu 315 gac Asp gca Al a ga t Asp gCC Ala ctt Leu 395 gaa Giu gtc Val1 ga t Asp tat Tyr gat Asp ctt Leu gga Gly cca Pro gcc Ala 300 ctg Leu cgc Arg act Thr 9CC Ala ggc Gly 380 cta Leu gtt Val aac Asn ctc Leu gac Asp 4 60 tac Tyr gac Asp gCC Al a gtg Val1 285 acc Th r ct C Le u ga a Giu tct Se r tat Tyr 365 tqg Trp gag Giu gtc Val1 ctc Le u aac As n 445 gtg Val1 gat Asp gcc Ala atc Ile 270 gag Glu aac Asn tca Ser aag Lys gtg Val1 350 gt C Val1 acc Thr ctc Le u acc Thr aac Asn 430 aag Lys ctg Leu tgg Trp gt C Val1 255 gt t Val1 gca Ala ggt Gi y ga C Asp atc Ile 335 Ct t Leu tac Tyr ctt Leu acc Thr atg Met 415 cca Pro at c Ile aaa L ys gca Ala 240 aa t Asn gct Ala cac His gtg Val1 atc Ile 320 atg Met gcg Al a gac Asp gat Asp ttc Phe 400 gtc Val1 ggt Gly cag Gin tcc Ser cca Pro tat Tyr ggc ci y ctg Le u aac As n 305 cg t Arg cgt Arg caa Gin cta Le u agc Ser 385 aac As n caa Gin ga C Asp gt t ValI ca g Gin 465 cca Pro gtc Val1 caa Gin aag Lys 290 aac Asn gtt Val gtg Val1 aat As n gac Asp 370 qac Asp gaa Glu gaa Giu caa Gin cgc Arg 450 ctg Leu tca Ser ctc Leu ggt Gly 275 ga t Asp agc Ser cgc Arg ctg Leu gca Ala 355 aaa Lys 9gc Gi y gcc Al a cag Gin gca Al a 435 ca c His tac Tyr cgc Arg gcg Al a 260 gat Asp gca Al a ttc Phe caa Gin ttt Phe 340 ctg Leu gca Al a atg Met ctc Leu Ct c Leu 420 gcc Ala acc Thr t cc Ser gaa Glu 245 ggt Gly atc Ile Gly aac As n gct Ala 325 agt Se r ggc ci y aca Thr cgt Arg cca Pro 405 99 t Gly cag Gin atg Met acc Thr 835 883 931 979 1027 1075 1123 1171 1219 1267 1315 1363 1411 1459 1507 aac cgc aac gag ctg ttg aac atg acc gtg gaa ggg gag acc gcc gat 1555 Asn Arg Asn Glu Leu Leu Asn Met Thr Val Glu Gly Giu Thr Ala Asp 470 475 480 485 att ggc gat cct cat ttg gag gaa ctc ctc atg gct att gca tcc agc 1603 Ile Gly Asp Pro His Leu Glu Glu Leu Leu Met Ala Ile Ala Ser Ser 490 495 500 cca cgc gaa gag qac cgt gca gca gca tct gcc gca gca cag gat tac 1651 Pro Arg Giu Giu Asp Arg Ala Ala Ala Ser Ala Ala Ala Gin Asp Tyr 505 510 515 atc acc gag cag gca tat gtt ctt cca ctg ttt gaa gag oca gtt gtc 1699 Ile Thr Glu Gin Ala Tyr Val Leu Pro Leu Phe Giu Giu Pro Val Val 520 525 530 tac ggc gtg cag cct tac gtg aag ggc ttt agc ccc gaa gtg atc ggc 1747 Tyr Giy Val Gin Pro Tyr Val Lys Giy Phe Ser Pro Glu Val Ile Gly 535 540 545 cgc ccc agc ttc tat gag acc tac att gac cat tcc agc gac cat tcc 1795 Arg Pro Ser Phe Tyr Giu Thr Tyr Ile Asp His Ser Ser Asp His Ser 550 555 560 565 agt gag gag gac taaatgacta cctcgcagat tct 1830 Ser Glu Glu Asp <210> <211> 569 <212> PRT <213> Corynebacterium giutamicum <400> Val Phe Lys Lys His Arg His Giy Leu Giy Ser Pro Ciu Thr Lys Pro 1 5 10 Arg Ser Ile Thr Arg Arg Phe Phe Thr Ala Ala Ala Ala Thr Leu Ala 25 Gly Leu Ala Val Leu Ser Gly Cys Thr Ala Gin Pro Ser Gin Ala Glu 40 Asp Asn Thr Leu Thr Tyr Leu Glu Pro Gin Phe Phe Arg Thr Leu Tyr 55 Pro Pro Ser Ala Gly Phe Tyr Pro Asn Gly Ser Val Val Asn Asn Ile 70 75 Ala Asp Arg Leu Leu Tyr Gin Asp Pro Giu Thr Leu Giu Leu Lys Pro 90 Trp Ilie Ala Thr Giu Leu Pro Glu Val Asn Glu Asp Ala Thr Glu Phe 100 105 110 Thr Phe Asn Ile Arg Thr Asp Vai Thr Tyr Ser Asp Gly Thr Pro Leu 115 120 125 Thr Ala Giu Asn Val Val Lys Asn Phe Asp Leu Tyr Gly Leu Gly Asp 130 135 140 Gin Asp Arg Arg Leu Thr Ile Ser Glu Gin Ile Thr Asn Tyr Asp His 160 145 150 155 Gly Aila Aia Al a Leu 225 Pro Tyr Gly Leu Asn 305 Arg Arg Gin Leu Ser 385 Asn Gin Asp Giu Pro Asp Gin 210 Gi y Pro Val1 Gin Lys 290 Asn Vali Val1 Asn Asp 370 Asp Glu Giu Gin Val1 Phe 180 Thr Vai Asn Arg Ala 260 Asp Al a Phe Gin Phe 340 Le u Aila Met Leu Le u 420 Aila Asp 165 Aila Leu Ile Leu Glu 245 Gly Ile Gi y Asn Aila 325 Ser Giy Thr Arg Pro 405 Gly Gin Glu Gin Giu Giy Thr 230 His Giu Ala Ile Phe 310 Leu Asp Tyr Ala Arg 390 Gin Asp Asp Asp Ala Phe Ser 215 Le u Gln Glu Arg Pro 295 Arg Ile Ser Lys Leu 375 Lys Pro Leu Ala Thr Thr Ala 200 Giy Thr Gly Ser Gin 280 Ile Phe His Tyr Glu 360 Leu Asp Arg Gly Asp 440 Val1 Ser 185 As n Pro Ala Arg Val1 265 Ile Ile Lys Al a Pro 345 Gin Asp Gly Se r Ile 425 Ser Arg 170 Ser Glu Phe Arg Ala 250 Arg Glu Ser As n Ile 330 Leu Val1 Giu Glu Arg 410 Lys Lys Phe Phe Asp Val1 Gi u 235 Lys Ile Al a Ala Glu 315 Asp Ala Asp Ala Le u 395 Glu Val1 Asp His As n Phe Ile 220 Asp Leu Gly Pro Ala 300 Leu Arg Thr Al a Gly 380 Leu Val1 As n Leu Phe Ala Al a 205 Thr Tyr Asp Ala Val1 285 Thr Leu Glu Ser T yr 365 Trp Glu Val Leu Asn 445 Ser Gi y 190 Pro Asp Asp Ala Ile 270 Glu Asn Ser Lys Val 350 ValI Thr Leu Thr As n 430 Lys Glu 175 Leu Gly Glu Trp Val1 255 Val1 Ala Gly Asp Ile 335 Leu Tyr Leu Thr Met 415 Pro Ile Pro Tyr As n Thr Ala 240 As n Ala His Val1 Ile 320 Met Ala Asp Asp Phe 400 Val1 Gly Gin Val Arg 450 His Thr Met Val Gly Arg Ala Asp Tyr Asp Val Leu Lys Ser Gin 465 Gly Ala Al a Giu Pro 545 Ser Leu Glu Ile Al a Glu 530 Glu Tyr Th r Ala Gin 515 Pro Val1 Ser Al a Ser 500 Asp ValI le Thr Asp 485 Ser Tyr Val1 Gi y Ser 565 As n 470 Ile Pro Ile Tyr Arg 550 Ser Giu Pro Giu 505 Gin Gin Phe Asp Leu 475 Leu Arg T yr Tyr Glu 555 Met Giu Ala Leu 525 Lys Tyr Giu 480 Met Al a Ph e Ser His 560 Ser Asp His <210> 21 <211> 858 <212> DNA <213> Corynebacterium giutamicun <220> <221> CDS <222> (101)..(835) <223> RXN00784 <400> 21 gtcacatcag ttatcgogcg gaatagttag ogggcgcatg tggttqggat atatgaataa atctattcca, actacgogta aaacgaggac gtttaaagot atg tot att gca Al a ttc Phe gac Asp ooa. Pro gac Asp gto Val1 cca Pro tc Cys oa q Gin qgo Gi y gc Ala caa Gin goa Ala tao Tyr gc Ala ota. Leu aag Lys goa Al a aaa Lys ato Ile gga Gly gaa. Glu ggo Giy atg Met at o Ile aag Lys ga a. Gi u 45 cc a Pro ct C Leu gc Ala gaa, Giu ogo Arg gtg Val1 otg Leu gag Glu aoo Thr g tg Val oto Leu gaa. Giu ogt Arg oag Gin gga Giy tgg Trp gao Asp tao Tyr too Ser gc Al a ott Leu Ser gao Asp goo Al a ago Ser gtt Val1 oaa. Gin atg Met ttc Phe t go Cys aoo Thr oto Leu ct C Leu ggo: Gly gao Asp gaa Glu gcg Al a got Al a t cc Ser 150 ctc Leu gc Ala aaa Lys gta Val ttt Phe 230 acc Thr aaa Lys cac His 135 att Ile ga a Glu og c Arg tac Tyr ga a Glu 215 gag Glu atc Ile gcc Al a 120 ttc Phe got Al a t cc Ser oaa Gin gco Ala 200 aaa Lys gt o g og Ala 105 cac His gta ValI gca Al a gao Asp ct C Leu 185 atc Ile g cc Ala att. gc Al a ggo Gly gao Asp gag Giu gtg Val1 170 ggc Gly aac As n tto Phe gac aac Asn aag Lys ggc Gly gtt Val1 155 tao Tyr gtc ValI ggo Sly gaa Giu ggC aoo ato Thr Ile oaa oaa Gin Gin 125 aag aao Lys Asn 140 ggt oto Gly Leu aoo aao Thr Asn oaa ggt Gin Gly goc oaa Ala Gin 205 gag tgg Glu Trp 220 oaa ago Gin Ser aac As n 110 gaa Glu gt t Val1 gat Asp gaa Giu gtg Val1 190 oaa Gin goa Ala t go Cys 95 gog Ala gtg Val1 gat Asp goo Al a gto Val1 175 000 Pro ga a Glu goo Al a too Ser cao cgo Ott His Arg Leu gog Ala gao Asp agt. Ser 160 caa Sin ttc Phe gaa Glu gaa Glu gto Val 240 Met Sly Arg Thr Met 75 oag Sin oto Leu 145 gca Al a caa Gin ttt Ph e gta Val aao Asn 225 gao Asp Lys Lys Ile His Ser gaa Siu 130 gat Asp goo Ala gao Asp gta Val tto Phe 210 ooa Pro ggo- Gly 100 aoo oao Thr His 115 oto tto Leu Phe gtg otg Vai Leu ogc gaa Arg Siu gto oao Val His 180 tto gao Phe Asp 195 aoo ggc Thr Gly gto ago Val Ser aoo tgo Thr Cys tto Phe aag Lys gto Val1 got Al a 165 ga a Slu ogo Arg aoo Thr ooa Pro aao Asn 245 Trp Asp Tyr Se r Ala Val Ile Asp G1 taaottttgg gaootatgtg ogt <210> 22 <211> 245 (212> PRT <213> Corynebaoterium giutamioun <400> 22 Met Ser Ile Giu Phe Ser Ala Pro Ala Lys 1 5 10 Ser Asp Ile Met Cys Pro Phe Cys Tyr Ile 25 Asp Ala Leu Ser Thr Phe Asp Gin Ala Sly 40 Lys Ser Phe Giu Leu Met Pro Sly Leu Glu 55 Asp Val Glu Tyr Leu Ala Asp Ala Lys Gly 70 Ile Giu Val Lys Arg Leu Giu Val Glu Pro Leu Arg Leu Sin Gin Arg Gin Met Asn Gly Gin Val Gin Ala Met 90 Ala Gin Ala Thr Gly Leu Glu Arg Gin Le u 145 Ala Gin Phe Val Asn 225 Asp Met Leu Giu 130 Asp Ala Asp Val1 Phe 210 Pro Gly As n Thr 115 Le u Val1 Arg Val1 Phe 195 Thr Val1 Thr Pro 100 His Ph6 Leu Glu His 180 Asp Gly Ser Cys Asp Phe Lys Val1 Ala 165 Glu Arg Thr Pro Asn 245 Giu Thr Ala Lys Ala His 135 Ser Ile 150 Leu Glu Ala Arg Lys Tyr Val Glu 215 Phe Glu 230 Ile Al a 120 Phe Ala Ser Gin Al a 200 Lys Val1 Ala 105 His Val Ala Asp Le u 185 Ile Al a Ile Al a Gly Asp Glu Val1 170 Gly Asn Phe Asp As n Lys Gly Val1 155 T yr Val1 Gly Glu Gly 235 T hr Gin Lys 140 Gly Thr Gin Al a Giu 220 Gin Ile Gin 125 As n Le u As n Gi y Gin 205 Trp Ser As n 110 Giu Val1 Asp Gl u Val1 190 Gin Al a Cys Ala Val1 Asp Ala Val1 175 Pro Glu Ala Ser His Al a Asp Ser 160 Gin Phe Giu Giu Val1 240 <210> 23 <211> 1896 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1873) <223> RXA02335 <400> 23 tggttgagtt cttcggggtt gagtgtgcaa gaatattcac gtctacccac tgagtcatca atttaaatca ggagttatta agg aag atc acc aag gtt ctt gtc gct aac cgt Arg Lys Ile Thr Lys Val Leu Val Ala Asn Arg 15 cgc gtg ttc cgt gca gct cga gat gaa ggc atg Arg Val Phe Arg Ala Ala Arg Asp Glu Gly Met 30 tac gca gag cca gat gca gat gca cca ttc gtg tattggtcag gcaactatgt gtg tca gtc gag act 115 Val Ser Val Giu Thr 1 ggt gag att gca atc 163 Gly Glu Ilie Ala Ile gga tct gtc gcc gtc 211 Gly Ser Val Ala Val tca tat gca gac gag 259 Tyr Ala Giu Pro Asp Ala Asp Al a 45 Pro Phe Val Ser Tyr Ala Asp Giu gCt ttt Ala Phe gcc ctc ggt ggo Ala Leu Gly Gly aca tcc got gag Thr Ser Ala Glu tao ctt gtc att Tyr Leu Val Ile gac Asp aag atc atc gat Lys Ile Ile Asp gcg Al a gcc cgc aag too Ala Arg Lys Ser gcc gac gcc atc Ala Asp Ala Ile coo ggc tao ggc Pro Gly Tyr Gly ctc gca gaa aac gct gac ttc gca gaa Leu Ala Glu Asn Ala Asp The Ala Giu gca gtc Ala Val 100 atc aac gaa Ile Asn Giu tcc: ctc ggc Ser Leu Gly 120 ggc Gi y 105 ctg atc tgg att Leu Ile Trp Ile cot tca oct gag Pro Ser Pro Glu tcc atc cgc Ser Ile Arg 115 aoc gcc aag Thr Ala Lys 451 499 gac aag gtc acc Asp Lys Val Thr cgc cac atc goa Arg His Ile Ala gat Asp 130 got oca Ala Pro 135 atg got ccot ggo Met Ala Pro Gly aag gaa cca gta Lys Giu Pro Val gao goa gca gaa Asp Ala Ala Glu gtg got ttc got Val Ala Phe Ala gaa ttc ggt cto Giu Phe Gly Leu cca Pro 160 atc gcc ato aag Ile Ala Ile Lys gca Ala 165 547 595 64 3 gct ttc ggt ggc Ala Phe Gly Gly gga cgt ggc atg Gly Arg Gly Met gtt gcc tac aag Val Ala Tyr Lys atg gaa Met Glu 180 gaa gtc got Giu Val Ala ttc ggo ogo Phe Gly Arg 200 gao Asp 185 oto: tto gag too Leu Phe Giu Ser goa Al a 190 aoc ogt gaa gca Thr Arg Glu Ala aoc gca gog Thr Ala Ala 195 aag goa cgo Lys Ala Arg ggo gag tgo tto Gly Giu Cys Phe gag cgo tao otg Giu Arg Tyr Leu gao Asp 210 691 739 787 835 cac gtt His Val 215 gag got oag gto Glu Ala Gin Val atc Ile 220 gcc gat aag oao Ala Asp Lys His aao gtt gtt gto Asn Val Val Val goo Ala 230 gga acc ogt gao Gly Thr Arg Asp too otg oag ogo Ser Leu Gin Arg ogt Arg 240 tto oag aag otc Phe Gin Lys Leu gto Val1 245 gaa gaa goa ooa Glu Glu Ala Pro goa cca tto oto aoo gat gao cag ogo gag ogt oto Ala Pro Phe Leu Thr Asp Asp Gin Arg Giu Arg Leu 250 -255 260 883 oao too too His Ser Ser aag got ato tgt Lys Ala Ile Cys aag Lys 270 gaa got ggo tao Giu Ala Gly Tyr tao ggt goa Tyr Gly Ala 275 ggo acc gtt gag tao ctc gtt ggc too gao ggo otg ato tcc tto oto Gly Thr Val Giu Tyr Leu Val Gly Ser Asp Gly Leu Ile Ser Phe Leu 28029 290 gag qtc Glu Val 295 aac acc cgc ctc Asn Thr Arg Leu cag Gin 300 gtg gaa cac cca Val Glu His Pro acc gaa gag acc Thr Giu Glu Thr acc Thr 310 ggc atc gac ctg Gly Ile Asp Leu cgc gaa atg ttc Arg Glu Met Phe cg c Arg 320 atc gca gaa ggc Ile Ala Glu Gly ca c His 325 1027 1075 1123 gag ctc tcc atc Giu Leu Ser Ile aag Lys 330 gaa gat cca gct Giu Asp Pro Ala cgc ggc cac gca Arg Gly His Ala ttc gag Phe Giu 340 ttc cgc atc Phe Arg Ile ggc aag atc Gly Lys Ile 360 aac As n 345 ggc gaa gac gct Gly Glu Asp Ala ggc GI y 350 tcc aac ttc atg Ser Asn Phe Met cct gca cca Pro Ala Pro 355 gtc cgc atg Val Arg Met 1171 1219 ace agc tac cgc Thr Ser Tyr Arg cca cag ggc cca Pro Gin Gly Pro ggc Gly 370 gac tcc Asp Ser 375 ggt gtc gtt gaa Gly Val Val Giu tcc gaa atc tcc Ser Giu Ile Ser cag ttc gac tcc Gin Phe Asp Ser atg Met 390 ctg gca aag ctq Leu Ala Lys Leu atc Ile 395 gtt tgg ggc gac Val Trp Giy Asp acc Thr 400 cgc gag cag gct Arg Giu Gin Ala ct C Leu 405 cag cgc tcc egc Gin Arg Ser Arg gca ctt gca gag Ala Leu Ala Giu gtt gte gag ggc Val Vai Giu Giy atg cea Met Pro 420 1267 1315 1363 1411 1459 acc gtt atc Thr Val Ile ggc aac gac Giy Asn Asp 440 eca. Pro 425 ttc cac cag eac Phe His Gin His atc Ile 430 gtg gaa aac cca Val Glu Asn Pro gca ttc gtg Ala Phe Vai 435 gaa gag gtt Glu Giu Val gaa. ggc ttc gag Giu Giy Phe Glu tac acc aag tgg Tyr Thr Lys Trp atc Ile 450 tgg gat Trp Asp 455 aac cca ate gca Asn Pro Ile Ala tac gtt gac gct Tyr Val Asp Ala gag ctc gac gaa Giu Leu Asp Giu gat Asp 470 gag gac aag acc Glu Asp Lys Thr gca cag aag gtt Ala Gin Lys Val gt t Val 480 gtg gag atc aac Val Gu Ile Asn 1507 1555 1603 cgt ego gtt gag Arg Arg Val Glu gca ctc cca ggc Ala Leu Pro Gly etg gca ctc ggt Leu Ala Leu Giy ggc ac Giy Thr 500 get ggt ect Ala Gly Pro gct ggc gta Ala Gly Val 520 aag Lys 505 aag aag gec aag Lys Lys Ala Lys egt cgc gca ggt Arg Arg Ala Giy ggt gca aag Gly Ala Lys 515 ggc act gtc Gly Thr Val 1651 1699 tcc ggc gat gca Ser Gly Asp Ala gtg ValI 525 gca gct cca atg Ala Ala Pro Met cag Gin 530 atc aag gtc aac gte gaa gaa ggc Ile Lys Val Asn Val Glu Glu Gly 535 540 gtt gtt gtc ctc gag gct. atg aag Val Val Val Leu Glu Ala Met Lyst 550 555 aag tcc gga acc gta acc ggc ctt Lys Ser Gly Thr Va Thr Gly Leu 570 aac aag ggc qtt gtt etc ctc gag Asn Lys Gly Val Val Leu Leu Giu 585 agt <210> 24 <211> 591 <212> PRT <213> Corynebacterium glutamicum gaa Glu ga a Glu gte ValI 575 aag Lys gte aac gaa ggc gac acc Val. Asn Glu Gly Asp Thr 545 aac cet gtg aag get cat Asn Pro Val Lys Ala His 560 565 get. gca ggc gag ggt gte Ala Al.a Gly Glu Gly Val 580 taagttettg gatteetgtt 1747 1795 1843 1893 1896 <400> 24 Val. Ser Val Glu Thr Arg Lys Ile Thr Lys Val Leu Val Ala Asn 1 Gly Gly Ser Ser Ala Phe Pro Ala Lys 145 Ile Ala Glu Ser Tyr Tyr Asp Ala Glu Asp 130 Asp Al a Tyr Al a Ala Asp Val1 Ile Al a 100 Ile Ala Al a Lys Met 180 5 Ile Val Glu Ile His Val1 Ar g Lys Glu Al a 165 Glu Phe Glu Ala Ile Tyr Glu Gi y 120 Met Al a Gly Ala 10 Arg -Ala 25 Pro Asp Leu Gly Ile Asp Gly Phe 90 Gly Leu 105 Asp Lys Ala Pro Phe Ala Gly Gly 170 Asp Leu 185 Ala Ala Gly Ala Leu Ile Val1 Gly Glu 155 Gly Phe Asp Ala Thr Arg Glu Ile Ala 125 Lys Phe Gly Ser Glu Pro Ser Lys Asn Gly 110 Arg Glu Gly Met Ala 190 Gly Phe Ala Ser Ala Pro His Pro Leu Lys 175 Thr Glu Leu Gly 225 Phe Gin Gly Leu Val 305 Ile Gly Phe Pro Gly 385 Arg Val Asn Trp Ser 465 Val Ala Ala Asp 210 Asn Gin Arg Tyr Ile 290 Thr Ala His Met Gly 370 Gin Glu Glu Pro Ile 450 Glu Glu Leu Thr 195 Lys Val Lys Glu Tyr 275 Ser Glu Glu Ala Pro 355 Val Phe Gin Gly Ala 435 Glu Leu Ile Gly Ala Ala Val Leu Arg 260 Gly Phe Glu Gly Phe 340 Ala Arg Asp Ala Met 420 Phe Glu Asp Asn Gly 500 Ala Arg Val Val 245 Leu Ala Leu Thr His 325 Glu Pro Met Ser Leu 405 Pro Val Val Glu Gly 485 Thr Phe His Ala 230 Glu His Gly Glu Thr 310 Glu Phe Gly Asp Met 390 Gin Thr Gly Trp Asp 470 Arg Ala Gly Val 215 Gly Glu Ser Thr Val 295 Gly Leu Arg Lys Ser 375 Leu Arg Val Asn Asp 455 Glu Arg Gly Gly Ala Arg Pro Ala 265 Glu Thr Asp Ile Asn 345 Thr Val Lys Arg Pro 425 Glu Pro Lys Glu Lys 505 Glu Gin Asp Ala 250 Lys Tyr Arg Leu Lys 330 Gly Ser Val Leu Arg 410 Phe Gly Ile Thr Val 490 Lys Cys Val Cys 235 Pro Ala Leu Leu Val 315 Glu Glu Tyr Glu Ile 395 Ala His Phe Ala Pro 475 Ala Lys Phe Ile 220 Ser Phe Ile Val Gin 300 Arg Asp Asp Arg Gly 380 Val Leu Gin Glu Pro 460 Ala Leu Ala Val 205 Ala Leu Leu Cys Gly 285 Val Glu Pro Ala Glu 365 Ser Trp Ala His Ile 445 Tyr Gin Pro Lys Glu Asp Gin Thr Lys 270 Ser Glu Met Ala Gly 350 Pro Glu Gly Glu Ile 430 Tyr Val Lys Gly Lys 510 Arg Lys Arg Asp 255 Glu Asp His Phe Pro 335 Ser Gin Ile Asp Tyr 415 Val Thr Asp Val Asp 495 Arg Tyr His Arg 240 Asp Ala Gly Pro Arg 320 Arg Asn Gly Ser Thr 400 Val Glu Lys Ala Val 480 Leu Arg Ala Met Asn 545 Pro Al a Gl y Gin 530 Glu Val1 Gly Gly 515 Gly Gly Lys Glu Al a Thr Asp Ala Gly 580 Gly Lys 535 Val1 Ser Lys Ser Asn Leu Thr Val1 585 Asp Glu Ala 555 Thr Leu Ala Glu 540 Met Gly Leu Val1 525 Gly Lys Leu Glu Ala Pro Glu Val Glu Asn 560 Val Ala 575 Lys <210> <211> 1575 <212> DNA <213> Corynebacterium glutamicun <220> <221> CDS <222> (1552) <223> RXA02173 <400> ctaaattgqg ottagatctt ccgcctctaa ataggtatgc aga acaaagccat ttttcggccg tggagaagcg ttttccgact atg gacattc gaattaatta tgg ggc atg ga a Glu agc Ser 9gC Gly gaa Glu gtt Val gcq Ala ct C Leu ca c His ttc Phe tat Tyr t cg Ser att I le tog Ser cca Pro act Th r att Ile gca Al a gt a Val ttg Leu gtg Val ctg Le u gca Al a t gg Trp acc Thr act Thr ga t Asp at c Ile gtc Val1 ttg Leu aat As n t tg Le u gga Gl y ttt Phe 75 atg Met t cc Ser ctc Leu act Thr Cgg Arg ggc Cl y ttC Phe gcg Ala got Ala ata gao Ile Asp coo caa Pro Gln gct cga Ala Arg acc qtg Thr Val ctc ggc Leu Gly att cac Ile His tco ggt Ser Gly 110 Met 1 gt t Val gac Asp aaq Lys ggC Gly tot Ser gcc Ala gcg Ala Trp gao Asp Ct 0 Le u aaa Lys cg Pro qgc Cl y gag Glu atg Met 115 Met gao Asp caa Gln gat Asp gc Ala gto Val aaa Lys gaa Glu gac aat cga Asp Asn Arg 120 gct ttt gtc atg Ala Phe Val Met gtg tcc ata aco Val Ser Ile Thr gct gtg cag Ala Val Gin cgt cac Arg His 135 cgc gag gcg cat Arg Glu Ala His ocg ttc ctg gtg Pro Phe Leu Val tat Tyr 145 ttg cgc aat ccc Leu Arg Asn Pro atg ggt ggc gcc Met Gly Gly Ala atg Met 155 gc tog tgg ggt Ala Ser Trp Gly tct ggg cat ctc Ser Gly His Leu ttt gcg gaa ccc Phe Ala Giu Pro ggc Gly 170 gcg cag ata ggt Ala Gin Ile Gly ttc Phe 175 ctg ggt cct cgo Leu Gly Pro Arg gtg gtg Val Val 180 gag tta acc Glu Leu Thr aat ttg gtg Asn Leu Val 200 ggg cat gcg ctt Gly His Ala Leu gao ggt gtg cag Asp Gly Val Gin cag gog gag Gin Ala Glu 195 cca ctc caa Pro Leu Gin 691 739 aaa act ggt gtg Lys Thr Gly Val gat gga att gtg Asp Giy Ile Val tcg Ser 210 ttg ogt Leu Arg 215 gca gog gtg gca Ala Ala Val Ala aaa Lys 220 acc otc aag gtt Thr Leu Lys Val cag cog gta gag Gin Pro Val Glu gca Ala 230 acg gat cgt ttt Thr Asp Arg Phe cca aca act cct Pro Thr Thr Pro gtg gca ott ccg Val Ala Leu Pro 787 835 883 atg gag gog att Met Giu Ala Ile gcg Ala 250 ogt tot ogt gao Arg Ser Arg Asp ccg Pro 255 cag agg cot gga Gin Arg Pro Gly atc ggg Ile Gly 260 gag att atg Glu Ile Met ogt got ggc Arg Ala Gly 280 acg ttg ggg gca Thr Leu Gly Ala gtc gtc aag ott Val Val Lys Leu tot ggt gcg Ser Gly Ala 275 gcg cgc atc Ala Arg Ile 931 979 gca ttg ago ccg Ala Leu Ser Pro got Ala 285 gtg cgc gtt gc Val Arg Val Ala ctg Leu 290 ggg ggo Gly Gly 295 ogg ccc gtg gtg Arg Pro Val Val att ggg oag gat Ile Gly Gin Asp cgc tto acg ott Arg Phe Thr Leu ggg Gly 310 ccg cag gag ctg Pro Gin Glu Leu cgt Arg 315 ttt gog cgt ogt Phe Ala Arg Arg att tog ctg gcg Ile Ser Leu Ala 1027 1075 1123 gag ota aac ctg Glu Leu Asn Leu ato gtg too ato Ile Val Ser Ile gao aco too ggo Asp Thr Ser Gly gc gaa Ala Glu 340 ttg tog oag Leu Ser Gin gcg Ala 345 got gag gag otc Ala Glu Glu Leu ato gca ago tcg Ile Ala Ser Ser att gog cgo Ile Ala Arg 355 1171 aco ttg too aag Ott ato gao got ccc otc ccc acc gtt tog gtc att 1219 Thr Len Ser Lys Leu Ile Asp Ala Pro Leu Pro Thr Val Ser Val Ile 360 365 370 att ggt cag ggc gtt ggc ggt ggc gcg ctg gcc atg ctg CCC 9CC gat 1267 Ile Gly Gin Gly Val Gly Gly Gly Ala Len Ala Met Leu Pro Ala Asp 375 380 385 ctg gtc tac gcg gcc gaa aac gcg tgg ctg tcc gca ttg cca cca gag 1315 Leu Val Tyr Ala Ala Glu Asn Ala Trp Leu Ser Ala Leu Pro Pro Giu 390 395 400 405 ggc gcc tcg gcc atc ctc ttc cgc gac acc aac cac gcc gcg gaa atc 1363 Gly Ala Ser Ala Ile Leu Phe Arg Asp Thr Asn His Ala Ala Gin Ile 410 415 420 ata gag cga caa ggc gtg cag gcg cac gca ctt tta agc caa ggg ctt 1411 Ile Gin Arg Gin Gly Val Gin Ala His Ala Leu Len Ser Gin Gly Leu 425 430 435 atc gac ggg atc gtc gcc gaa acc gag cac ttt gtt gaa gaa att ctc 1459 Ile Asp Gly Ile Val Ala Gin Thr Gln His Phe Val Gin Glu Ile Len 440 445 450 ggc aca atc agc aac gcc ctc tcc gaa ttg gat aac aat ccg gag agg 1507 Giy Thr Ile Ser Asn Ala Len Ser Glu Leu Asp Asn Asn Pro Giu Arg 455 460 465 gcg gga cgc gac agt cgc ttc aca cga ttt gag cgt tta gcg cag 1552 Ala Giy.Arg Asp Ser Arg Phe Thr Arg Phe Gin Arg Len Ala Gin 470 475 480 taaaqaaaat tatgcgctga ica 1575 <210> 26 <211> 484 <212> PRT <213> Corynebacterinm glutamicum <400> 26 Met Val Trp Gly Met Gin His Thr Ser Ala Len Thr Leu Ile Asp Ser 1 5 1'0 Vai Len Asp Pro Asp Ser Phe Ile Ser Trp Asn Gin Thr Pro Gin Tyr 25 Asp Asn Len Asn Gin Giy Tyr Ala Gin Thr Len Gin Arg Ala Arq Ser 40 Lys Ala Lys Cys Asp Gin Ser Val Ile Thr Gly Gin Gly Thr Val Gin 55 Giy Ile Pro Val Ala Val Ile Len Ser Asp Phe Ser Phe Len Gly Gly 70 75 Ser Len Gly Thr Val Ala Ser Val Arg Ile Met Lys Ala Ile His Arg 90 Ala Thr Gin Len Lys Len Pro Len Len Vai Ser Pro Ala Ser Gly Gly 100 105 110 Ala Arg Met AlaArgMetGn Giu Asp Asn Arg Ala Phe Val Met Met Val Ser Ile Thr Tyr 145 Ser Gly Val1 Val1 Ile 225 Val1 Arg Lys Ala Arg 305 Ile Thr Ser Thr Met 385 Ala His Leu Al a 130 Leu Giy Pro Gin Ser 210 Gin Ala Pro Leu Leu 290 Arg Ser S er Ser Val 370 Leu Leu Ala Ser 115 Al a Arg His Arg Gin 195 Pro Pro Le u Gly Ser 275 Al a Phe Le u Gly Ile 355 Ser Pro Pro Al a Gin Val1 As n be u Val1 180 Al a Leu Val1 Pro Ile 260 Gly Arg Thr Ala Al a 340 Al a Val1 Al a Pro Giu 420 Gly Gin Pro Th r 165 Val1 Giu Gin Glu Val1 245 Gly Al a Ile Le u Ar g 325 Giu Arg Ile Asp Glu 405 Ile Leu Arg Thr 150 Phe Giu As n Leu Al a 230 Met Glu Arg Gly Gly 310 Glu Le u Thr Ile Leu 390 Gly Ile Ile His 135 Met Ala Leu Leu Arg 215 Thr Glu Ile Ala Gly 295 Pro Leu Ser Leu Gly 375 Val Ala Giu Asp 120 Arg Gly Giu Thr Val1 200 Al a Asp Al a Met Gi y 280 Arg Gin As n Gin Ser 360 Gin Tyr Ser Ar g Gi y Giu Gly Pro Th r 185 Lys Al a Arg Ile Giu 265 Ala Pro Giu Le u Al a 345 Lys Gly Ala Ala Gin 425 Ile Al a Ala Gly 170 Gly Thr Val1 Ph e Ala 250 Thr Leu Val1 Le u Pro 330 Al a Leu Val1 Al a Ile 410 Gi y Val1 His Met 155 Ala His Gly Ala Ser 235 Arg Le u Se r Val1 Arg 315 Ile GlIu. Ile Gly Giu 395 Leu Val Al a Leu 140 Ala Gin Ala Val1 Lys 220 Pro Ser Gly Pro Leu 300 Phe Val1 Giu Asp Gly 380 Asn Phe Gin Glu 125 Pro Ser Ile Leu Ile 205 Thr Thr Arg Al a Ala 285 Ile Ala Ser Leu Ala 365 Gly Ala Arg Ala Tb r Leu Gly Phe 175 Asp Gly Lys Pro Pro 255 Val1 Arg Gin Arg Ile 335 Ile be u be u Le u Thr 415 Ala His Val1 Ser 160 Le u Gi y Ile Val1 Gly 240 Gin Val1 Val1 Asp Gly 320 Asp Al a Pro Al a Se r 400 As n Leu Phe Val Giu Giu Ile Leu Gly Thr Ile Ser Asn Ala Leu 450 455 460 Asn Asn Pro Glu Arg Ala Gly Arg Asp Ser Arg Phe 465 470 475 Ser Giu Leu Asp Thr Arg Phe Giu 480 Arg Leu Ala Gin <210> 27 <211> 10 <212> ON <213> Co <220> <221> CD <222> 1 <223> RX 56 A rynebacterium S (1033) A0 17 64 glut amicum <400> 27 ttttcaaaat taatagttga catttteaae qttatgagtt ttcattggta tcacqececg acgaagtgte tgggatcaca aaectteaaa gqagtttgaa atg tct etc aat Met Ser Leu Asn 1 aaa gte gcc ate Lys Val Ala Ile gt t Val1 ace gga tct ggt Thr Gly Ser Gly gga ctt ggt Gly Leu Gly get cag gag Ala Gin Glu aac cag gca Asn Gin Ala gee cgt cag ggt Ala Arg Gin Gly gca Ala tct gte atc gtc Ser Val Ile Val egt tec ttc Arg Ser Phe aat gac gta Asn Asp Val gaa gee gge Glu Ala Gly gee gea gat gag Ala Ala Asp Giu gte gea gea ate Val Ala Ala Ile ggc aaa Giy Lys gee gee gee gtt Ala Ala Ala Val ate Ile 60 gee eee gtt gga Ala Pro Val Gly eee Pro tet gaa age gee Ser Glu-Ser Ala gea Al a ttg etg gtg egg Leu Leu Val Arg gee gte gae aag Ala Val Asp Lys ggt tet ttg gae Gly Ser Leu Asp ett gte aca aae Leu Val Thr Asn gge ate ett egt Gly Ile Leu Arg agg tee etg Arg Ser Leu aeg gae gat Thr Asp Asp tte ace tgt Phe Thr Gys 120 gat Asp 105 tte gat gea gte Phe Asp Ala Val att Ile 110 aac gtg cac etc Asn Val His Leu ctg aag atg Leu Lys Met 100 aag ggc act Lys Gly Thr 115 aat gga ate Asn Gly Ile 403 451 499 gtt ege gag gca Val Arg Glu Ala gga tae tte aag Gly Tyr Phe Lys qg gqg Ala Gly 135 cgc atc gtc acg Arg Ile Val Thr ggt tct ccc acc Gly Ser Pro Thr ggg Gly 145 cag cgc ggc aac Gin Arg Gly Asn gga cag age aat Gly Gin Ser Asn tac Tyr 155 get gca gct aag Ala Ala Ala Lys ggc att gtg gqt Gly Ile Val Gly atg Met 165 gtt egc acg tgg Val Arg Thr Trp etg gag atg aag Leu Giu Met Lys ege Arg 175 gea ggt gtc ace Ala Gly Val Thr att aac Ile Asn 180 geg ate att Ala Ile Ile tte cag aag Phe Gin Lys 200 gaa gea gee ace Glu Ala Ala Thr atg ace aag aeg Met Thr Ly's Thr gtg eca tat Vai Pro Tyr 195 atg eca gea Met Pro Ala get gta gag gee Ala Val Giu Ala gat Asp 205 gag cgt gge gag *Giu Arg Gly Glu gee Al a 210 tte ttC Phe Phe 215 ege gag ace eta Arg Giu Thr Leu ggt Gi x 220 ttt ggc aet ect Phe Gly Thr Pro gat gtt gcg gga Asp Val Ala Gly ett Leui 230 gtg gee tte ett Val Ala Phe Leu tct gat gag gea Ser Asp Giu Ala aat att tet gga Asn Ile Ser Gly cag Gin 245 gee ate ggt gea Ala Ile Gly Ala gge gae ege atg Gly Asp Arg Met eag Gin 255 gtg tgg aag eac Val Trp Lys His cea gag Pro Glu 260 cca gea gtt Pro Ala Val eag gaa, egt Gin Glu Arg 280 gaa ttt aae eca Glu Phe Asn Pro gg t Gly 270 gge tgg ace tat Gly Trp Thr Tyr gaa gca etg Glu Ala Leu 275 tee gte ggt Ser Val Gly gge aag aae att Gly Lys Asn Ile gag gge aae etg Giu Gly Asn Leu eag Gln 290 gte gtt Val Val 295 aag gea Ly's Ala 310 ttc ect gaa etg Phe Pro Giu Leu ceg Pro 300 gea gag ett eag Ala Glu Leu Gin eca Pro 305 eaa ate eca gte Gin Ile Pro Val 1027 1056 taaeacegea caeeaagaat ttt <210> 28 <211> 311 <212> PRT <213> Corynebacterium giutamleum <400> 28 Met Ser Leu Asn Gly Ly's Val Ala Ile Vai Thr Gly Ser Gly Ala Gly 1 5 10 Leu Gly Arg Ser Phe Ala Gin Giu Leu Ala Arg Gin Gly Ala Ser Val 25 Ile Val Asn Asp Val Asn Gin Ala Ala Ala Asp Glu Thr Val Ala Ala 40 Ile Thr Glu Ala Gly Gly Lys Ala Ala Ala Val Ile Ala Pro Val Gly 55 Pro Ser Glu Ser Ala Ala Leu Leu Val Arg Glu Ala Val Asp Lys Phe 70 75 Gly Ser Leu Asp Ile Leu Val Thr Asn Ala Gly Ile Leu Arg Asp Arg 90 Ser Leu Leu Lys Met Thr Asp Asp Asp Phe Asp Ala Val Ile Asn Val 100 105 110 His Leu Lys Gly Thr Phe Thr Cys Val Arg Glu Ala Phe Gly Tyr Phe 115 120 125 Lys Glu Asn Gly Ile Ala Gly Arg Ile Val Thr Ile Gly Ser Pro Thr 130 135 140 Gly Gin Arg Gly Asn Phe Gly Gin Ser Asn Tyr Ala Ala Ala Lys Ala 145 150 155 160 Gly Ile Val Gly Met Val Arg Thr Trp Ala Leu Glu Met Lys Arg Ala 165 170 175 Gly Val Thr Ile Asn Ala Ile Ile Pro Glu Ala Ala Thr Asp Met Thr 180 185 190 Lys Thr Val Pro Tyr Phe Gin Lys Ala Val Glu Ala Asp Glu Arg Gly 195 200 205 Glu Ala Met Pro Ala Phe Phe Arg Glu Thr Leu Gly Phe Gly Thr Pro 210 215 220 Gin Asp Val Ala Gly Leu Val Ala Phe Leu Ser Ser Asp Glu Ala Ala 225 230 235 240 Asn Ile Ser Gly Gin Ala Ile Gly Ala Gly Gly Asp Arg Met Gin Val 245 250 255 Trp Lys His Pro Glu Pro Ala Val Thr Glu Phe Asn Pro Gly Gly Trp 260 265 270 Thr Tyr Glu Ala Leu Gin Glu Arg Gly Lys Asn Ile Ile Glu Gly Asn 275 280 285 Leu Gin Ser Val Gly Val Val Phe Pro Glu Leu Pro Ala Glu Leu Gin 290 295 300 Pro Gin Ile Pro Val Lys Ala 305 310 <210> 29 <211> 1827 <212> DNA <213> Corynebacterium glutamicum <220> <221> <222> <22 3> CDS (1804) RXN 02487 <400> 29 teatagetac gcgcatgccc acattctaga tcgccgaaga atactaaagg gcactaaagc aacgcagttg aagggacacc aagcagcggg acgtctctat atg tca gca tac gaa 11 Met Ser Ala Tyr Giu 1 acc aaa gaa tgg Thr Lys Glu Trp Ct C Le u cag cac tac cca Gin His Tyr Pro tgg aeg eca cac Trp Thr Pro His tcg ctg Ser Leu gaa tat ggc GiU Tyr Gly gac Asp acc acc ctg Ctg Thr Thr Leu Leu gtt tac gac aac Val Tyr Asp Asn aac ctg gCC Asn Leu Ala tca caa acc Ser Gin Thr att aac gca gac aag cca gcc acc tac ttt ttc ggt cgt Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe Giy Arg 45 tac ggt Tyr Giy gaa ctg gac aaa Giu Leu Asp Lys gaa Glu 60 gtc cgc aaa act Val Arg Lys Thr gee Al a get gqc ctg cge Ala Giy Leu Arg g ca Ala eta ggt gte cgc Leu Gly Val Arg ggc gat cac gta Gly Asp His Val att ate ctc ccc Ile Ile Leu Pro ige cca cag cac Cys Pro Gin His ate Ile gca get ttc tac Ala Ala Phe Tyr gea Ala 95 gtg etg aaa etc Val Leu Lys Leu ggc gca Gly Ala 100 gta gtc att Val Val Ile CCC ttc aaa Pro Phe Lys 120 gag Giu 105 cac aac ccg etc His Asn Pro Leu ace gee cac gaa Thr Ala His Giu etg etc gaa Leu Leu Giu 115 gac aaa gcc Asp Lys Ala gac cac ggt gcc Asp His Gly Ala gtt gee ate gte Val Ala Ile Val tgg Trp 130 tee ccc Ser Pro 135 ace gte gaa eag Thr Val Glu Gin egt gga cag ac Arg Gly Gin Thr cag Gin 145 ttg gaa ace ate Leu Giu Thr Ile gtg Val1 150 teg gte aac atg Ser Val Asn Met aac geg atg eca Asn Ala Met Pro eca Pro 160 etc cag cge eta Leu Gin Arg Leu ett egg etc eea Leu Arg Leu Pro ate Ile 170 ect gca etg ege Pro Ala Leu Arg aag Lys 175 age ege gaa tee Ser Arg Glu Ser etc tee Leu Ser 180 ggc gca gee Gly Ala Ala CCC Pro 185 aae ace gtt cet Asn Thr Val Pro gaa aec ctg ace Giu Thr Leu Thr age gca gea Ser Ala Ala 195 atg gge gge gac gge qac gac gta gtt tea gaa ccc ace gtg ace aaa Met Gly Giy Asp Gly Asp Asp Val Val Ser Giu Pro Thr Val Thr Lys 739 200 00205 210 gaa tcc Giu Ser 215 gte gcg ctg atc Val Ala Leu Ile tac acc tee ggc Tyr Thr Ser Gly acc gga cgc ccc Thr Gly Arg Pro aag Lys 230 ggt gcc cag etc Gly Ala Gin Leu acc Thr 235 cac gga aac ctg His Gly Asn Leu ttc Phe 240 ttc aat ctt. ctt Phe Asn Leu Leu gga aag cac tg Gly Lys His Trp eca ggt ctc gga Pro Gly Leu Gly ga c Asp 255 aaa cca gaa cge Lys Pro Glu Arg atg ctt. Met Leu 260 gca gcc eta Ala Ala Leu ctg tec gtg Leu Ser Vai 280 atg tte cae gca Met Phe His Ala tac Tyr 270 ggt etg acc atg Giy Leu Thr Met gte ggc aca Val Gly Thr 275 ace cea cgc Thr Pro Arg ttc atc ggt ggc Phe Ile Gly Gly atq gtg cta ett Met Val Leu Leu ate gac Ile Asp 295 ctg ate atg aac Leu Ile Met Asn atg aaa aag eac Met Lys Lys His eca ace tgg cta Pro Thr Trp Leu eca Pro 310 ggc gtg ccc acc Giy Val Pro Thr tac gaa aaa ate Tyr Giu Lys Ile gac gee tee gaa Asp Ala Ser Glu aaa. Lys 325 gaa gqa ate ccc Glu Gly Ile Pro ate Ile 330 aag gga gte cgc Lys Gly Val Arg aac Asn 335 gcc ttc tcc ggt Aia Phe Ser Gly gca tee Ala Ser 340 aca etc tee Thr Leu Ser cgc cte gte Arg Leu Val 360 eqe ace qtt gaa Arg Thr Val Giu tgg gaa aag cac Trp Giu Lys His ace gqe gga Thr Gly Gly 355 ate ate gtg Ile Ile Val 1027 1075 1123 1171 1219 1267 1315 1363 gaa gge tae gge Giu Gly Tyr Gly etc Leu 365 ace gaa ace tee Thr Giu Thr Ser ggt aac Gly Asn 375 eec atg age gat Pro Met Ser Asp cac His 380 ega ege caa gge Arg Arg Gin Gly gta gga ate ec Val Gly Ile Pro eec gac ace ate Pro Asp Thr Ile gtg ValI 395 ege ate gea aae Arg Ile Ala Asn c ca. Pro 400 gaa aac etc gac Glu Asn Leu Asp ace atg ccc gac Thr Met Pro Asp age gaa ggc gaa Ser Giu Giy Giu eta. gte aag qg Leu Val Lys Gly eca cag Pro Gin 420 gtg tte aag Val Phe Lys eac gge gag His Giy Giu 440 ggt Gly 425 tac etc aae cag Tyr Leu Asn Gin gaa Giu 430 gaa gee ace aag Giu Ala Thr Lys aae age ttc Asn Ser Phe 435 gaa gaa gac Giu Giu Asp 1411 1459 tgg tac ege ace Trp Tyr Arq Thr gge Gly 445 gac gte gga gtg Asp Vai Gly Val ggg Gly ggt Gly 470 cca Pro tcc Ser gat Asp a ag Lys atg Met 550 ct c Leu ttc atc cqc cta Ile aac As n att Ile aac As n ga t Asp 520 ccg Pro aag Lys aag Lys gt t Val1 cca Pro 475 tcc Ser gct Ala aag Lys ttc Phe 09 t Arg 555 got Ala 460 gct Al a gca Ala gcc Ala gaa Glu tac Tyr 540 cgt cgc atc aag gaa gtC ato atc act 990 Arg gag Glu gtC Val1 atc Ile ttc Phe 525 cac His gaa Ile gtt Val gtt Val1 act Thr 510 900 Ala ttt Phe gtg Lys gaa Glu ggt Gly 495 t tg Leu 090 Arg gag Glu cag Ile ctc Leu cgt Arg gg t Gly ct 0 Leu 530 ocg Pro ttg Leu Thr gag Glu gac ASP 500 909 Ala cgc Arg gat Asp aag Lys Gly ca c His 485 990 Gi y ctg Leu tao Tyr ca g Gin aag Lys 565 1507 1555 1603 1651 1699 1747 1795 Arg Giu Val Gin tagaogccga tttaagaggt cga 1827 <210> <211> 568 <212> PRT <213> Corynebaoterium glutamioum <400> Met Ser Ala Tyr Glu Thr Lys Giu Trp 1 5 Thr Pro His Ser Leu Giu Tyr Gly Asp Asp Asn Asn Leu Ala Ile Asn Ala Asp 40 Gly Arg Ser Gin Thr Tyr Gly Glu Leu 55 Ala Ala Gly Leu Arg Ala Leu Gly Val 70 Ile Ilie Leu Pro Asn Gys Pro Gin His Le u Thr Lys Asp Arg Ile Gin Thr Pro Lys Pro 75 Al a His Le u Ala Giu Gly Ala Tyr Le u Thr Val Asp Phe Trp Tyr Ph e Thr Al a Val1 Leu Lys Leu Gly Ala Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala His Giu Leu Leu Giu Pro Phe 115 Val1 Gin 145 Leu Arg Leu Pro Thr 225 Phe Pro Thr Leu Thr 305 Asp Phe Lys Ser Tyr 385 Giu Val1 Thr Trp 130 Leu Gin Giu Thr Thr 210 Thr Asn Glu Met Pro 290 Pro Ala Ser His Pro 370 Val1 Asn Lys Lys Asp Glu Arg Ser Ser 195 Val1 Gly Leu Arg Val1 275 Thr Thr Ser Gly Th r 355 Ile Gly Leu Gly As n Lys Thr Leu Leu 180 Al a Thr Arg Leu Met 260 Gly Pro Trp Giu Al a 340 Gly Ile Ile Asp Pro 420 Ser Al a Ile Al a 165 Se r Ala Lys Pro Gin 245 Leu Thr Arg Leu Lys 325 Se r Giy Val1 Pro Giu 405 Gin Phe Ser Val1 150 Leu Gly Met Glu Lys 230 Gly Ala Leu Ile Pro 310 Glu Th r Ar g Giy Phe 390 Thr Val1 His Pro 135 Ser Arg Ala Gly Ser 215 Gly Lys Ala Ser Asp 295 Gly Gly Leu Leu Asn 375 Pro Met Phe Gly Lys 120 Thr Val1 Leu Ala Gly 200 Val1 Ala His Leu Val1 280 Le u Val1 Ile Se r Val1 360 Pro Asp Pro Lys Glu Asp His Gly Ala Arg Val Ala Ile 125 Val1 As n Pro Pro 185 Asp Al a Gin T rp Pro 265 Phe Ile Pro Pro Gin 345 Glu Met Thr Asp Gly 425 Trp Gin Ile 155 Pro Thr Asp Ile Thr 235 Pro Phe Gly As n Leu 315 Lys Thr Tyr Asp Val1 395 Ser Leu Arg Arg Ala Leu Pro Val 205 Tyr Gly Leu Ala Glu 285 Met Glu Val Glu Leu 365 Arg Ile Gly Gin Gly Gly Met Arg Phe 190 Val Thr Asn Gly Tyr 270 Met Lys Lys Arg Arg 350 Thr Arg Ala Glu Glu 430 Asp Gin Pro Lys 175 Glu Ser Ser Leu Asp 255 Gly Val1 Lys Ile Asn 335 Trp Giu Gin Asn Val1 415 Giu ValI ValI Val1 465 ValI Pro Glu Asn Met 545 Glu Met 450 Ile Leu Arg Gly Leu 530 Pro Leu 435 Glu Ile Ala Glu Al a 515 Thr Arg Le u Asp Gl y His 485 Gly Le u Tyr Gin Lys 565 Phe 455 Phe Asp Glu Pro Val1 535 Gly Gly Leu T yr Asp 490 Val1 Leu Thr Arg 445 Arg Glu Val1 Ile Phe 525 His Glu Lys Glu Gly 495 Leu Arg Glu Gln <210> 31 <211> 411 <212> DNA <213> Corynebacterium glutamicun <220> <221> CDS <222> (388) <223>' FRXA02487 <400> 31 ggcgagtggt accgcaccgc gacgtcggag tgatgaagaa tgctcgcatc aagaaagtca tcatcactgg cggtttcaac gt t Val1 gtt Val1 act Thr gc Ala ttt gtc ValI ccg Pro ga a Glu aac Asn atg ctc Leu cgt Arg ggt Gly cto Leu ccg goa gag Ala Glu gaa gac Glu Asp gca gcg Ala Ala acc cgc Thr Arg cgg gat ca c His ggc Gl y ctg Leu tac Tyr cag att Ile aac Asn gat Asp cog Pro aag gcogggttca tccgcotagt gtg tac cca got gag Val Tyr Pro Ala Glu 1 gaa gat too gca gto Glu Asp Ser Ala Val gto gtt gct goc atc Val Val Ala Ala Ile ggc ctg aag gaa ttc Gly Leu Lys Glu Phe cgc act ttc tao cao Arg Thr Phe Tyr His att agg ogt cgt gaa 115 163 211 259 307 355 Phe Giu Glu Met Pro Arg Asp Gin Met Gly Lys Ile Arg Arg Arg Glu 75 80 gtg cag gcg gag ttg ttg aag aag ctc ggc aag tagacgccga tttaagaggt 408 Val Gin Ala Glu Leu Leu Lys Lys Leu Gly Lys cga 411 <210> 32 <211> 96 <212> PRT <213> Corynebacterium giutamicum <400> 32 Val Tyr Pro Ala Glu Val Giu Giu Val Leu Ala Glu His Pro Asp Ile 1 5 10 Glu Asp Ser Ala Val Val Gly Ile Pro Arg Glu Asp Gly Ser Giu Asn 25 Val Val Ala Ala Ile Thr Leu Val Glu Gly Ala Ala Leu Asp Pro Asp 40 Gly Leu Lys Giu Phe Ala Arg Lys Asn Leu Thr Arg Tyr Lys Val Pro 55 Arg Thr Phe Tyr His Phe Giu Giu Met Pro Arg Asp Gin Met Gly Lys 70 75 Ile Arg Arg Arg Giu Val Gin Ala Giu Leu Leu Lys Lys Leu Gly Lys 90 (210> 33 <211> 913 <212> DNA <213> Corynebacterium giutamicum (220> <221> CDS <222> (101)..(913) <223> FRXA02490 <400> 33 toatagotac gogcatgcoo acattotaga tcgocgaaga aagcaqcggg aogtototat atactaaagg goaotaaago aacgoagttg aagggacaco atg tca gca tao gaa 115 Met Ser Ala Tyr Giu 1 aco aaa gaa tgg cto cag cac tac oca gag tgg acg cca c 'ac tog otg 163 Thr Lys Giu Trp Leu Gin His Tyr Pro Giu Trp Thr Pro His Ser Leu 15 gaa tat ggo gao acc acc otg ctg gao gtt tao gao aao aac otg goc 211 Giu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr Asp Asn Asn Leu Ala att aac gca Ile Asn Ala gac aag cca gcc Asp Lys Pro Ala tac ttt ttc ggt Tyr Phe Phe Gly tca caa ace Ser Gin Thr tac ggt Tyr Gly gaa ctg gac aaa Giu Leu Asp Lys gaa Giu 60 gtc cgc aaa act gcc get ggc etg cgc Vai Arg Lys Thr Ala Ala Gly Leu Arg gca Aia cta ggt gtc cgc Leu Gly Val Arg ggc gat cac gta Gly Asp His Val gcg Ala att ate ctc ccc Ile Ile Leu Pro tgc eca cag cac Cys Pro Gin His gca gct ttc tac Ala Ala Phe Tyr gtg ctg aaa ctc Val Leu Lys Leu ggc gca Gly Ala 100 gta gtc att Val Val Ilie ccc ttc aaa Pro Phe Lys 120 gaq Giu 105 cac aac ccg ctc His Asn Pro Leu aec gcc cac qaa Thr Ala His Glu ctg ctc gaa Leu Leu Glu 115 gac aaa gcc Asp Lys Ala gac cac ggt gcc Asp His Gly Ala eg c Arg 125 gtt gcc atc gte Val Ala Ile Val t gg Trp 130 tcc ccc Ser Pro 135 acc gte gaa cag Thr Val Glu Gin cgt gga cag ace Arg Gly Gin Thr cag Gin 145 ttg gaa acc atc Leu Giu Thr Ile gtg Val 150 tcg gte aac aty Ser Val Asn Met aac gcg atg cca Asn Ala Met Pro cca Pro 160 ctc cag cgc eta Leu Gin Arg Len ett cgg ctc cca Leu Arg Leu Pro ate Ile 170 cct gea ctg cgc Pro Ala Leu Arg aag Lys 175 agc ege qaa tcc Ser Arg Giu Ser ctc tee Leu Ser 180 ggc gca qCC Gly Ala Ala atg ggc ggc Met Gly Gly 200 aac acc gtt ect Asn Thr Val Pro qaa ace etg acc Glu Thr Leu Thr age gca gca Ser Ala Ala 195 gtg ace aaa Val Thr Lys gac gge gac gac Asp Giy Asp Asp gta Val1 205 gtt tea gaa ec Val Ser Glu Pro gaa tee Glu Ser 215 gte geg ctg ate Val Ala Leu Ile tac ace tee gge Tyr Thr Ser Gly ace Thr 225 ace gga ege ccc Thr Gly Arg Pro aag Lys 230 ggt gee eag etc Gly Ala Gin Leu eac gga aae etg His Gly Asn Leu tee aat etc etc Ser Asn Leu Leu 787 835 883 gga aag cac tgg Gly Lys His Trp gt t Vai 250 eca ggt etc gga Pro Gly Leu Giy gae Asp 255 aaa eca gaa ege Lys Pro Giu Arg atg ctt Met Leu 260 gca gee eta Ala Ala Leu atg ttc cae yea Met Phe His Ala tae ggt Tyr GIly 270 <210> 34 <211> 271 <212> PRT <213> Corynebacterium glutamicum <400> 34 Met Ser Ala Tyr Glu Thr Lys Glu Trp Leu Gin His Tyr Pro Glu Trp 1 5 10 Thr Pro His Ser Leu Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr 25 Asp Asn Asn Leu Ala Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe 40 Gly Arg Ser Gin Thr Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr 55 Ala Ala Gly Leu Arg Ala Leu Gly Val Arg Pro Gly Asp His Val Ala 70 75 Ile Ile Leu Pro Asn Cys Pro Gin His Ile Ala Ala Phe Tyr Ala Val 90 Leu Lys Leu Gly Ala Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala 100 105 110 His Glu Leu Leu Glu Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile 115 120 125 Val Trp Asp Lys Ala Ser Pro Thr Val Glu Gin Leu Arg Gly Gin Thr 130 135 140 Gin Leu Glu Thr Ile Val Ser Val Asn Met Ile Asn Ala Met Pro Pro 145 150 155 160 Leu Gin Arg Leu Ala Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser 165 170 175 Arg Glu Ser Leu Ser Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr 180 185 190 Leu Thr Ser Ala Ala Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu 195 200 205 Pro Thr Val Thr Lys Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly 210 215 220 Thr Thr Gly Arg Pro Lys Gly Ala Gin Leu Thr His Gly Asn Leu Phe 225 230 235 240 Ser Asn Leu Leu Gin Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys 245 250 255 Pro Glu Arg Met Leu Ala Ala Leu Pro Met Phe His Ala Tyr Gly 260 265 270 <210> <211> 414 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (391) <223> RXA01467 <400> gcgtcatctt tagccttgct ttatgagctt ttccccgcaa taagtcttag cctacaagcg ctttgaggta gtttgggatc tgagccgcgt tgtgtatcca atg gat ttc aac qac Met Asp Phe Asn Asp 1 aaa gcc gct tca gaa aac gct gta aag act ggc gca gaa ggc ccc aac Lys Ala Ala Ser Glu Asn Ala Val Lys Thr Gly Ala Glu Gly Pro Asn 15 gtt ttc gcg agc gtg gcc aag att ttg cag gat gtt ggc gga att tca Val Phe Ala Ser Val Ala Lys Ile Leu Gln Asp Val Gly Gly Ile Ser 30 gcc gaa gac gtc act ccg gaa tct cgt ttt act gag gat ttq gca gtg Ala Glu Asp Val Thr Pro Glu Ser Arg Phe Thr Glu Asp Leu Ala Val 45 agc tca ctc aat tac atc gag ttq att gtc aat gcg gag gac gca ttt Ser Ser Leu Asn Tyr Ile Glu Leu Ile Val Asn Ala Glu Asp Ala Phe 60 ggt gtt cgc att gag gac gcc gat gcc aag gat ttg acc acc gtg cag Gly Val Arg Ile Glu Asp Ala Asp Ala Lys Asp Leu Thr Thr Val Gln 75 80 gat ttg att gac ttt att aac acc aat aag gct gat tagcgggaaa Asp Leu Ile Asp Phe Ile Asn Thr Asn Lys Ala Asp atttcgccca aaa <210> 36 <211> 97 <212> PRT <213> Coryriebacterium glutamicum <400> 36 Met Asp Phe Asn Asp Lys Ala Ala Ser Glii Asn Ala Val Lys Thr Gly 1 5 10 Ala Glu Gly Pro Asn Val Phe Ala Ser Val Ala Lys Ile Leu Gln Asp 25 Val Gly Gly Ile Ser Ala Glu Asp Val Thr Pro Glu Ser Arg Phe Thr 40 Glu Asp Leu Ala Val Ser Ser Leu Asn Tyr Ile Glu Leu Ile Val Asn 55 Ala Glu Asp Ala Phe Gly Val Arg Ile Glu Asp Ala Asp Ala Lys Asp 70 75 Leu Thr Thr Val Gin Asp Leu Ile Asp Phe Ile Asn Thr Asn Lys Ala 90 Asp <210> 37 (211> 298 <212> DNA <213> Corynebacterium giutamicun <220> <221> COS <222> (298) <223> RXA00796 <400> 37 ctggaatccc aaagcgcttg catgacgcgg aaagttaaca gttgatacat caacttaatt aacttttaga ggagtacacc atc atc acc ggt tcc acc cgt cca ggc cgc Ile Ilie Thr Giy Ser Thr Arg Pro Gly Arg 15 aac tgg gtt ctc gag cgc gca caa gag cgc Asn Trp Val Leu Giu Arg Ala Gin Giu Arq 30 ctc gtt gat atc qcc gat ttc aac ttc ccc Leu Val Asp Ile Ala Asp Phe Asn Phe Pro 45 cca gcc ggc tac ggc cag tat gca aac gag Pro Ala Gly Tyr Gly Gin Tyr Ala Asn Glu 60 (210> 38 <211> 66 <212> PRT <213> Corynebacterium giutamicum <400> 38 Met Ser Lys Ile Ala Ile Ile Thr Gly Ser 1 5 10 Asn Ile Asp Val Ala Asn Trp Val Leu Giu 25 Asp Ala Gin Tyr Giu Leu Val Asp Ile Ala 40 Leu Asp Glu Aia Met Pro Ala Gly Tyr Gly 55 gt c Val1 aac Asn gtc Val1 cac His taggctaggt acgtcaagtt atg agc aag atc gcc Met Ser Lys Ile Ala 1 aac att gac gta gcc Asn Ile Asp Val Ala gat gca cag tac gag Asp Ala Gin Tyr Giu ctc gac gaa gca atg Leu Asp Glu Ala Met acc aag Thr Lys 115 163 211 259 298 Thr Arg Pro Gly Arg Val Arg Ala Gin Glu Arg Asn Asp Phe Asn Phe Pro Val Gin Tyr Ala Asn Giu His Thr Lys <210> <211> <212> <213> <220> <221> <222> <223> 39 666 DNA Corynebacterium giutamicun CDS (101) (64 3) RXA01897 <400> 39 ctatttagat cgttcoggaa ccgatccacg cgccgatatc caotocctgg atgaactctt toactaggot ggootttatt gtttccggaa aggggttgct atg aaa att ggt Met Lys Ile Gly 1 atc otg g90 agt Ile Leu Gly Ser atc Ile cgc gaa 990 cgc Arg Giu Gly Arg gqc caa ggc gtt Gly Gin Gly Val gcc gat Ala Asp tgg gto atg Trp Val Met qaa ctc atc Giu Leu Ile gaa oaa ato ggg gct tat Glu Gin Ile Gly Ala Tyr 30 gac gca ccc gat Asp Ala Pro Asp gtg gaa ttt Val Giu Phe gaa too gcg Giu Ser Ala gac ctc aaa gct ttc aac gtg ccc ctg Asp Leu Lys Ala Phe Asn Val Pro Leu aca gtt Thr Val cca ggt tcc gcg Pro Gly Ser Ala ga t Asp aaa cag tac gac Lys Gin Tyr Asp ccq cgc gta act Pro Arg Val Thr tgg tca cag gcc Trp Ser Gin Ala gat qcc tgc gat Asp Ala Cys Asp C Ala ttc ctt ttc atc Phe Leu Phe Ile acc Thr cog gaa tac aac Pro Giu Tyr Asn cac His ggt gtg coo ggo Gly Val Pro Gly ttc aaa aat gcg Phe Lys Asn Ala tat gao Tyr Asp 100 atc ctg ggc Ile Leu Giy ggt gca gtc Gly Ala Val 120 gaa tgg ctg aac aaa acc gtc ggt ttc Giu Trp Leu Asn Lys Thr Val Gly Phe 110 att tcc tac Ile Ser Tyr 115 cag atc gtc Gin Ile Val gaa ggg atc cgt Giu Gly Ile Arg gtc gaa cag tgg Val Giu Gin Trp gcc acc Ala Thr 135 ttc aao atg tac Phe Asn Met Tyr ga t Asp 140 ato: cgc agc cag Ile Arg Ser Gin too ttt too acc: Ser Phe Ser Thr acc gag aac aac Thr Giu Asn Asn ggc act ttt gcg Gly Thr Phe Ala 000 Pro 160 aat gat oga cgo Asn Asp Arg Arg 000 Pro -165 qgt gaa cta atc cgc Ctc ctt gat agc ctc cta acg qct qtc cgc gat 643 Gly Glu Leu Ile Arg Leu Leu Asp Ser Leu Leu Thr Ala Val Arg Asp 170 175 180 taaggctctg aaatactaat gag 666 <210> 410 <211> 181 <212> PRT <213> Gorynebacteriun giutamicum <400> Met Lys Ilie 1 Gin Pro Leu Asp Phe Lys Gly T rp Leu 145 Asn Thr Giy Asp Le u Pro Le u As n Phe Arg 130 Ser Asp Aila Vali Vali Giu Arg Phe Ala Ile 115 Gin Phe Arg Val Gly Al a Glu Ser ValI Ile Tyr 100 Ser Ile Ser Arg Val Ile Leu Giy 5 Asp Trp Val Met Phe Giu Leu Ile 40 Ala Thr Val Pro 55 Thr Ala Trp Ser 70 Thr Pro Giu Tyr Asp Ile Leu Gly Tyr Gly Ala Val 120 Val Ala Thr Phe 135 Thr Phe Thr Giu 150 Pro Gly Giu Leu 165 Ser Giu 25 Asp Gly Gin As n As n 105 Glu As n Asn Ile Gin Leu Se r Al a His Giu Gly Met As n Arg Ile Lys Al a Ile 75 Gly Trp Ile Tyr Asn 155 Gi u Giy Ala Asp Asp Val1 Le u Ar g Asp 140 Giy Gly Al a Ph e Lys Ala Pro Asn Val1 125 Ile Thr Arg Tyr As n Gin C ys Gi y Lys 110 Val1 Arg Phe Gly Al a Pro Asp Al a Phe Val1 Gin Gin Pro 160 Ile Arg Leu Leu Asp Ser Leu Leu Arg Asp 180 <210> 41 <211> 375 <212> DNA <213> Corynebacterium glutamicum <220> <221> COS <222> (375) <223> RXN02809 <400> 41 aac ctc tcc gtc cca gca gca cta acc aac As n 1 gca Ala atg Met ca g Gin ttc Phe gac Asp att Ile Gly Leu gag Giu Gly atc Ile gaa Giu gct Ala cgc Arg gag Glu Ser tgg Trp gt t Val1 gca Al a tac Tyr atg Met gag Glu ct C Leu 115 Val1 aac As n cgc Arg cac His cct Pro ct t Leu tct Se r 100 CCC Pro Pro 5 aac Asn gca Al a gtt Val1 aac Asn gag Giu gcg Ala ga c Asp Al a aag Lys g ct Al a ca a Gin ttc Ph e 70 c a gj Gin aac As n tgg Trp Leu gca Ala cac His 40 acc Thr cct Pro gtt Val1 tat Tyr tcg Ser 120 Thr ggc Gi y 25 ctc Le u 99C Gly tcc Ser gtc Val cac H1is 105 cct Pro r hr Gly 25 Leu Gly Ser Val1 H'is 105 Asn atc Ile cgc Arg Ctg Leu gag Glu tgg Trp tta Leu ct t Leu Asn 10 Ile Arg Leu Glu Trp 90 Leu gcc Al a gtc Val1 ggC Gly Ctg Leu cag Gin 75 acc Thr a ga Arg ttc Phe Ala Val1 Gly Leu Gin Thr Arg ct t Leu t CC Ser atc Ile agc Ser ggc Gly aag Ly5 acc Thr gta Val1 Leu Ser Ile Ser Gly Lys Thr t cc Ser tac Tyr ctt Le u atc Ile atc Ile gca Ala cct Pro ttc Phe 125 Ser Tyr Leu Ile Ile Al a Pro tac Tyr ggC Gly tcc Se r ttc Ph e tcc Se r atg Met cac His 110 tc Se r gca Al a ct t Le u gac Asp gtg Val1 acc Thr agt Se r <210> 42 <211> 125 <212> PRT <213> Corynebacterium glutamicum <400> 42 Asn Leu Ser Val Pro Ala Ala Leu 1 5 Ala Giu Trp Asn Asn Lys Ala Ala Met Gly Val Arg Ala Ala Glu His 40 Gin Ile Ala His Val Gin Lys Thr 55 Phe Glu Tyr Pro Asn Phe Lys Pro 70 Asp Ala Met Leu Glu Gin Leu Val Ile Arg Glu Ser Ala Asn Val Tyr 100 Tyr Gly Ser Phe Se r Met His 110 Leu Ser Giu Thr Ser Ser Lys Gly Glu Leu Pro Asp Trp Asp Ser Pro Leu Phe Val Phe 115 120 125 <210> 43 <211> 273 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (273) <223> FRXA02809 <400> 43 gca gca cta acc aac gcc ctt tcct Ala Ala Leu Thr Asn Ala Leu Ser 1 1 5 aag gct gca ggc atc gtc tcc tac Lys Ala Ala Gly Ile Val Ser Tyr gct gag cac ctc cgc ggc atc cttt Ala Glu His Leu Arg Giy Ile Leu 40 caa aag acc qgc ctg ctg agc atct Gin Lys Thr Gly Leu Leu Ser Ile I ttc aaq cct tcc gag cag ggc atc Phe Lys Pro Ser Glu Gin Gly Ile 70 cag ctt gtt gtc tgg acc aag gca Gin Leu Val Vai Trp Thr Lys Ala ct C Leu t cc Ser gag Giu acc Thr t ct Ser t cc Ser tcc Ser g ca Al a ctt Leu gac Asp gtg Val 75 aco Th r gag Giu Gly atc Ile gaa Giu gct Al a aac As n gca Ala gtt Val1 aac As n gag Glu <210> 44 <211> 91 <212> PRT <213> Corynebacterium glutamicum <400> 44 Ala Ala Leu Thr Asn Aia Leu Ser Tyr Leu Ser 1 5 10 Lys Ala Ala Gly Ile Val Ser Tyr Gly Ser Ala 25 Ala Giu His Leu Arg Gly Ile Leu Ser Glu Leu 40 Gin Lys Thr Gly Leu Leu Ser Ile Phe Thr Asp 55 Phe Lys Pro Ser Giu Gin Gly Ile Ser Ser Val 70 75 Ala Giu Trp Asn Met Gly Val Arg Gin Ile Ala His Phe Giu Tyr Pro Asp Ala Met Leu As n Al a Val1 As n Giu Gin Leu Val Val Trp Thr Lys Ala Met Ser Thr <210> <211> 5745 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (5722) <223> RXN00113 <400> tctgogoatc ccactcgagq agctggcaaa cggccgcaoc atcgatgttg aggcacgcac ogactccatc gaagagtccg catooggoog tatcqttacc gtg cgo atc gtg oto acc Thr cgt Ar g ggC Gi y cag Gin tct Ser gtt Val1 goa Ala tcc Ser gag Glu cgc Arg 150 a cc Thr gga Gly g ca Al a gca Ala ggt Gly ggc Gly cag Gln atg Met ogt Arg 135 at t Ile 9gc Gly atc Ile gac Asp gtt Val1 tac T yr gac Asp oto Leu 105 ggc Gly ggo Gly ggc Gly gaa Glu ac Thr ga a Glu tot Ser aac Asn gca Al a got Al a atg Met ogo Arg aac Asn goa Al a aac As n gto Val oot Pro att Ile ctt Leu ott Leu oaa Gin ggt Gly 140 gtc Val aag Lys atg Met 30 gca Ala gao Asp ac Thr cao His tot Ser 110 aao Asn aag Lys ogo Arg otg Leu 15 got Ala aco Thr atg Met tot Ser ggo Gly 95 gag Glu gao Asp oct Pro gga Gly Arg ogo Arg gca Al a too Ser tto Phe got Al a otg Leu ggt Gly gao Asp 130 gag Glu ot g Leu Ile tto Phe ga t Asp tto Phe gc Al a gca Al a too Ser tgg Trp 115 ato Ile gt 0 Val1 otc Leu Val1 gca Al a too Ser at o Ile atg Met aag Lys got Al a 100 aco Thr aoo Thr aco Thr aag Lys Leu att Ile tao Tyr ogo Arg gt t Val1 ott Leu aco Thr tao Tyr gto Val1 tgo Cys got Ala 165 cot tcc acc gct Pro Ser Thr Ala tat Tyr 170 gtt tac oca agc Val Tyr Pro Ser ggo ato cag got Gly Ile Gin Ala aag ggc Lys Gly 180 atg ggc caa Met Gly Gin gag cgt gca Giu Arg Ala 200 gat cgc acc gca Asp Arg Thr Ala gca gag got cgc Ala Glu Ala Arg gct gtg tgg Ala Val Trp 195 too atc cag Ser Ile Gin 691 739 gat gca cac acc Asp Ala His Thr ogo Arg 205 goa aao otg ggc Ala Asn Leu Gly cag gto Gin Val 215 att gat gaa aac Ile Asp Giu Asn act gag otg aag Thr Giu Leu Lys ggg gac acc ac Giy Asp Thr Thr gtg cac cca got Vai His Pro Ala gtt ttg aac ctc Val Leu Asn Leu acc Thr 240 oag ttc acg cag Gin Phe Thr Gin gcg ctc 9CC gtg Ala Leu Ala Val gtt Val1 250 gcc tac got cag Ala Tyr Ala Gin gag ogo oto aag Giu Arg Leu Lys got goa Aia Ala 260 aac gca att Asn Ala Ile tao aoc goa Tyr Thr Ala 280 gao ggo too oto Asp Gly Ser Leu goa ggo oao too Ala Gly His Ser oto ggo gag Leu Gly Giu 275 gaa ggo gto Giu Giy Vai 931 979 ctg goa too ttg Leu Ala Ser Leu ggo Gi y 285 aao ato tto gaa Asn Ile Phe Giu otc Leu 290 ato gao Ile Asp 295 gtt gtg ttc too Val Val Phe Ser ogo Arg 300 ggt too goa atg Giy Ser Ala Met tCo Ctg gtt oca Ser Leu Val Pro 09 t Arg 310 gat gag aag ggo Asp Giu Lys Gly too aao tao ggt Ser Asn Tyr Gly ott Leu 320 900 goa tto ogt Ala Ala Phe Arg aao atg ato aao Asn Met Ile Asn goa 900 aoo gag Ala Ala Thr Giu gtg Val 335 gag aao tgq qtt Giu Asn Trp Val gao ogt Asp Arg 340 1027 1075 1123 1171 1219 qto got qaa Val Ala Giu gat ggo cag Asp Gly Gin 360 qaa Giu 345 too ggo gaa ttc Ser Gly Giu Phe cag atc gtt aao Gin Ile Val Asn tao aao gtt Tyr Asn Val 355 otg aag gcc Leu Lys Ala oag tao qoa gto Gin Tyr Ala Val ggt aoc ttg got Gly Thr Leu Ala 990 Gi y 370 oto aaq got tot qoa tot gca Leu Lys Ala Ser Ala Ser Ala 375 380 aao oca cgt got Asn Pro Arg Ala tao Tyr 385 gtg aao att coa Val Asn Ile Pro 990 Gi y 390 att gac gtg ooa Ile Asp Val Pro tto Ph e 395 oao too ago gtc His Ser Ser Val 090 ooa ggo Arq Pro Gly gtt cot Val Pro 405 1267 1315 1363 got tto goa gag aag otg gao gag otg otg ooa gag aoo ato gao att Ala Phe Ala Glu Lys 410 Leu Asp Glu Leu Le u 415 Pro Giu Thr Ile Asp Ile 420 gat got ctt Asp Ala Leu gag ctc acc Glu Leu Thr 440 cgc Arg 425 ggc cgc tac atc Giy Arg Tyr Ile aac ctg gtt got Asn Leu Val Ala ogt oct tto Arg Pro Phe 435 gtt cca tcc Val Pro Ser 1411 1459 cag agc ttc gtg Gin Ser Phe Vai gcc ato ott got Ala Ile Leu Ala gag ogc Glu Arg 455 cto aag ggc atc Leu Lys Gly Ile aag Lys 460 gtg gag Val Giu gac aco gac Asp Thr Asp 465 gag aac acc ctg Giu Asn Thr Leu gca Ala 470 cgt otg ctc otc Arg Leu Leu Leu gag ctg otg tot Glu Leu Leu Ser cag tto goa too Gin Phe Ala Ser 1507 1555 1603 1651 gtg ogt tgg ato Val Arg Trp Ile aoo oag got otg Thr Gin Ala Leu ato Ile 495 ato gat aoo gto Ile Asp Thr Val gat oag Asp Gin 500 atc atO gag Ile Ile Giu gto Val1 505 ggo ttg goa goa Gly Leu Ala Ala ooa aco otg aoo Pro Thr Leu Thr aao otg gca Asn Leu Ala 515 otg ogo aoo atg gat gto att ggo aag too ogo coa gta tto aac gtg Leu Arg Thr Met. Asp Val Ile Gly Lys Ser Arg Pro Vai Phe Asn Val 520 525 530 1699 gag cgc Glu Arg 535 gac cag gac acc Asp Gin Asp Thr atg ctc aac gat Met Leu Asn Asp gtt Val1 545 cgc cag gca cot Arg Gin Ala Pro gt t Val1 550 got gag gtt gaa Ala Glu Val Giu gaa goa gtt gag Giu Ala Val Glu gca cot goa goa Ala Pro Ala Ala gca gct oca gca Ala Ala Pro Ala got Ala 570 gag goa ooa gtt Glu Ala Pro Val got Al a 575 goa got ooa gta Ala Ala Pro Val goo gca Ala Ala 580 1747 1795 1843 1891 1939 goo goa oot Ala Ala Pro goc aat gcc Ala Asn Ala 600 oct gtt gga aao Pro Val Gly Asn cot gaa otg aag Pro Giu Leu Lys tto aao gct Phe Asn Ala 595 ato aac att Ile Asn Ile atc atg gtt oto Ile Met Val Leu got gic oag aao Ala Val Gin Asn gat cag Asp Gin 615 ato aoo goa gog Ilie Thr Ala Ala gat Asp 620 aoo tot gag ac Thr Ser Glu Thr ctg Leu 625 aoc aao ggt gtg Thr Asn Gly Val 1987 2035 too Ser 630 toa ogo ogt aao Ser Arg Arg Asn atg oto atg gao Met Leu Met Asp too aoc gag otg Ser Thr Giu Leu gtc ooa aoo ato gao ggo gca got gac got Val Pro Thr Ile Asp Gly Ala Ala Asp Ala gao gta got acc otg oag Asp Val Ala Thr Leu Gin 2083 gga cgt gtt Gly Arg Val Ctt tcc gag Leu Ser Glu 680 acc gca gct cc~t Thr Ala Ala Pro ggc Gi y 670 tac aag cct ttc Tyr Lys Pro Phe gga cca gtt Gly Pro Val 675 ggt gca gca Gly Ala Ala 2131 2179 aCC gtt cgt gca Thr Val Arg Ala ctt cgc gca ctg Leu Arg Ala Leu ggt ctg Gly Leu 695 aag acc tcc tac Lys Thr Ser Tyr atc I le 700 ggc gat cgc gtg Gly Asp Arg Val acc Thr 705 ggc acc tgg gga Gly Thr Trp Gly cca gaa agc tgg Pro Glu Ser Trp gca cac gtt gag Ala His Val Glu gaa ttg ctg ctg Glu Leu Leu Leu ggc Gly 725 acc cgc qaa ggc Thr Arg Glu Gly tcc gtc cgc ggc Ser Val Arg Gly aac ctg ggt agc Asn Leu Gly Ser ctg cct Leu Pro 740 2227 2275 2323 2371 2419 gct aac gca Ala Asn Ala gtg cag aat Val Gln Asn 760 agc aag ggc gac Ser Lys Gly Asp gtc Val1 750 gat qcg ctt atc Asp Ala Leu Ile gac gca gcc Asp Ala Ala 755 atg tcc tcc Met Ser Ser gtt gct gca gc Val Ala Ala Ala ggc acc agc gtc Gly Thr Ser Val t CC Se r 770 ggc ggt Gly Gly 775 gca gct tca ggt Ala Ala Ser Gly ggc Gly 780 gga gtt gtt gat Gly Val Val Asp t CC Ser 785 gca gca ctt gat Ala Ala Leu Asp gcc Ala 790 tac gca tCC aCC Tyr Ala Ser Thr gtcz Val1 795 act ggt gaa gaa Thr Gly Glu Glu ggc Gly 800 gtc Ctg gca aac Val Leu Ala Asn gtt Val1 805 2467 2515 2563 gCt cgc ggc atc Ala Arg Gly Ile tct cag ctt ggt Ser Gln Leu Gly ctc Leu 815 gac aCC aag gac Asp Thr Lys Asp gag gtt Glu Val 820 gaa ggc gca Glu Gly Ala ctg ggc acc Leu Gly Thr 840 atc gac acc gaa Ile Asp Thr Glu taC gac gCt gtC Tyr Asp Ala Val gaa gca gaa Glu Ala Glu 835 tCC gct gat Ser Ala Asp 2611 2659 ggc tgg ctg aag Gly Trp Leu Lys ctt Leu 845 gtc acc cca gtg Val Thr Pro Val 'zgt gcg Arg Ala 855 atc ttg ttc gac Ile Leu Phe Asp cgt tgg gca tct Arg Trp Ala Ser cgt gaa gat ctg Arg Glu Asp Leu gca Ala 870 cgc ctt gCC aac Arq Leu Ala Asn ggc Gl y 875 gag qat att gCC Glu Asp Ile Ala gag cgc ttt gct Glu Arg Phe Ala gga Gl y 885 2707 2755 2803 acg ggg gag acc Thr Gly Glu Thr gtc aaq Caa gct Val Lys Gln Ala gca tgg tgq gct gag cac qtt Ala Trp Trp Ala Glu His Val 895 900 gaa gac ac Glu Asp Thr gcg aag cca Ala Lys Pro 920 ctc gct gca acc Leu Ala Ala Thr ctq Leu 910 aag cag gtt tc Lys Gin Val Ser gag gtg get Glu Val Ala 915 ctg gtt ace Leu Val Thr gcc aac gag cca Ala Asn Glu Pro atc gac gat gtt Ile Asp Asp Val 2851 2899 2947 ~±ggt gcg C1 Gly Ala 935 get cct gag tog Ala Pro Giu Ser gcc ggt gca gtt Ala Gly Ala Val gcg Ala 945 get cge ctg ctg Ala Arg Leu Leu tee Ser 950 cag ggc gcg acc Gln Gly Ala Thr gtc Val 955 att etc acc gca Ile Leu Thr Ala aac gtc tec cag Asn Val Ser Gin 2995 3043 cgt aag gaa tac Arg Lys Glu Tyr ego aag etc tac Arg Lys Leu Tyr geg aac gca ace Ala Asn Ala Thr cot aac Pro Asn 980 gca aag ctg Ala Lys Leu gat gee gte Asp Ala Val 1000 tgg rrp 985 att gtt Oct gcg Ile Val Pro Ala atg tec tee tao ego gat gtt Met Ser Ser Tyr Arg Asp Val 995 gag cag ego gtc ace gte ggc Glu Gin Arg Vai Thr Val Gly 1010 3091 3139 atc gat tgg ate Tle Asp Trp Ile gge aac Gly Asn 1005 age acc gte ace gtg ac Ser Thr Val Thr Val Thr 1015 aag eca Lys Pro 1020 get etg ace Ala Leu Thr eca ace Pro Thr 1025 ott gog tao Leu Ala Tyr 3187 oca tte gca get eca Pro Phe Ala Ala Pro 1030 tec gta tee Ser Val Ser 1035 ggt ace ttg geg Gly Thr Leu Ala 1040 gat gea go eca 3235 Asp Ala Giy Pro 1045 eag get gaa aao Gin Ala Giu Asn cag gca ego ctg ete Gin Ala Arg Leu Leu 1050 etc tgg Leu Trp 1055 tee gtg gag Ser Val Glu ego ace Arg Thr 1060 3283 3331 ate gca gga. Ile Ala Gly ott gca gat ctt gee Leu Ala Asp Leu Ala 1065 too ego Ser Arg 1070 ggt gte get Gly Val Asp gga ego gte Gly Arg Val 1075 cac gtt gta etc His Val Val Leu 1080 coa ggt toce~cg aae ego gga atg Pro Gly Ser Pro Asn Arg Gly Met 1085 tte ggt ggc gac Phe Gly Gly Asp 1090 gge get tao ggc gaa gte Gly Ala Tyr Gly Glu Val 1095 eag get get tte Lys Ala Ala Phe 1100 tgg eca eag ttt Trp Pro Gin Phe .5 gee gee ate ott gee aag Asp Ala Ile Leu Ala Lys 1105 gte tee etc gee cag gea Val Ser Leu Ala Gin Ala 1120 3379 3427 3475 1125 tgg ggc tee gag ace Trp Gly Ser Giu Thr 1110 ggc Gly 111 ege ate ggc tgg gte gca ggc ace gge etc atg ggt cgc eec gao gtg 3523 Arg Ile Gly Trp Val Ala Gly Thr Gly Leu Met Gly Arg Asn Asp Val 1130 1135 1140 ctc ate cet gee get Leu Ile Pro Ala Ala 1145 gag atc tct tcc gaa Glu Ile Ser Ser Glu 1160 gaa aag ctg ggc ate Giu Lys Leu Gly Ile 1150 ctg ctg ggt ctt gca Leu Leu Gly Leu Ala 1165 cac gtc tac aec cet gaa His Val Tyr Thr Pro Glu 1155 tcc gca gaa tcc cgc gaa Ser Ala Giu Ser Arg Glu 1170 3571 3619 aag gct ctg Lys Ala Leu 1175 ggt ggc gta Gly Gly Val 1190 gaa gca ccg Giu Ala Pro atc gat Ile Asp 1180 tac gac etg Tyr Asp Leu acc qgt Thr Gly 1185 gga ctt tcc 3667 Gly Leu Ser tcc gac gca 3715 Ser Asp Ala 1205 tec atc gca gca ctg Ser Ile Ala Ala Leu 1195 gca gca tec ctc gag Ala Ala Ser Leu Giu 1200 gta gag acc ace tct gca gca gaa gac acc atc aag gcg ctt cca tea Val Glu Thr Thr Ser Ala Ala Glu Asp Thr Ile Ly's Ala Leu Pro Ser 1210 1215 1220 3763 cet aag eac Pro Lys His acc gat ctc Thr Asp Leu 1240 cca gag Pro Glu 1225 cag cca gtg Gin Pro Val ggc acg Gly Thr 1230 eca gtt gga Pro Val Gly gag gtc aag Giu Val Ly's 1235 3811 3859 gaa gac atg gtt G1u Asp Met Val gtc atg Val Met 1245 gtt gyc gtt Val Gly Val ggc gaa gtc tc Gly Giu Val Ser 1250 tca tgg gge tee gqa cgt Ser Trp Gly Ser Gly Arg 1255 acc egc Thr Arg 1260 ttc qaa get gag tac ggc atc cag Phe Glu Ala Giu Tyr Gly Ile Giln 1265 390 cgc gac Arg Asp 1270 ggc tcc gtt Gly Ser Val gac etc Asp Leu 1275 acc gca gca Thr Ala Ala ggc gtc Gly Val 1280 ctt gag ctt gca 3955 Leu Glu Leu Ala 1285 tgg atg atg ggt Trp Met Met Gly etg ate Leu Ile 1290 tee tgg age Ser Trp Ser gaa gat Giu Asp 1295 cca aag cca Pro Ly's Pro gee tgg Ala Trp 1300 4003 tac gac gct Tyr Asp Ala gac ggc acc gaa gtg Asp Gly Thr Glu Val 1305 cet gaa Pro Giu 1310 gaa gag atc Glu Giu Ile tac gag egc Tyr Glu Arg 1315 4051 ttc egc gac gaa Phe Arg Asp Glu 1320 gtc atc gca cga tgc Val Ile Ala Arg Cys 1325 ggt gtt cgt gag ctt gtc gac Gly Val Arg Giu Leu Val Asp 1330 4099 gac gca ttc Asp Ala Phe 1335 etc gtc gac Leu Val Asp ggc gge Gly Gly 1340 tec ete gae Ser Leu Asp gca get Ala Ala 1345 gaa gte tte 4147 Glu Val Phe gaa gca eag 4195 Glu Ala Gin 1365 cte gac cge gac ate Leu Asp Arg Asp Ile 1350 tee tte tee Ser Phe Ser 1355 gta aee tet get gaa Val Thr Ser Ala Giu 1360 gee tao gte gat qea gat get tee gtg ace Ala Tyr Val Asp Ala Asp Ala Ser Val Thr gtt gaa gaa gea gac gge Val Giu Giu Ala Asp Gly 5 1380 1370 137 4243 4291 gaa tgg ate gtg ace aag aag aag ggc tee ace tee tte gtg eca ege Glu Trp Ile Val Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arq 1385 1390 1395 aag qca acc ctg acc cgc tcc gta gca ggc cag ctg cca acc gac ttc Lys Ala Thr Leu Thr Arg Ser Val Ala Gly Gin Leu Pro Thr Asp Phe 1400 1405 1410 4339 gac cct gcc aaq tgg Asp Pro Ala Lys Trp 1415 ggt atc cca Gly Ile Pro 1420 gcc tcc atg atc gat Ala Ser Met Ile Asp 1425 gca ctc gac Ala Leu Asp 4387 aac atc Asn Ile 1430 gca gcg tgg Ala Ala Trp aac ctg Asn .Leu 1435 gtc act gca Val Thr Ala gtc gac Val Asp 1440 gcc ttc ctg tcc Aia Phe Leu Ser 4435 1445 tcc ggc ttc agc Ser Gly Phe Ser cca gca Pro Ala 1450 gaa ctc ctg Glu Leu Leu cag tcc Gin Ser 1455 atc cac cca Ile His Pro gct gac Ala Asp 1460 4483 gtg tcc tcc acc cag ggc acc ggt atc ggt ggc atg cag tcc cta cgc Val Ser Ser Thr Gin Gly Thr Gly Ile Gly Gly Met Gin Ser Leu Arg 4531 1465 1470 1475 aag ctg ttc Lys Leu Phe 1480 gtc aac cgc ttc Val Asn Arg Phe ctc ggc Leu Gly 1485 cag gat cgt Gin Asp Arq cca tcc gac atc Pro Ser Asp Ile 1490 4579 ctc cag gag acc ctg cca Leu Gin Giu Thr Leu Pro 1495 aac gtt Asn Val 1500 gtq qct gca Val Ala Ala cac acc His Thr 1505 atq cag tcc Met Gin Ser tac qtc gqt ggc tac Tyr Val Gly Gly Tyr 1510 ggc cag Gly Gin 1515 atg atc cac Met Ile His cca gtq Pro Val 1520 qca gca tgt gca Ala Ala Cys Ala 4627 4675 1525 4723 acc gca gct gtc Thr Ala Ala Val tcc gtg gaa qaa ggc Ser Val Giu Giu Gly 1530 qtg gac Val Asp 1535 aag atc cgc Lys Ile Arg ctc aac Leu Asn 1540 aag gca gat ttc gtt gtc gcc ggt Lys Ala Asp Phe Val Val Ala Gly 1545 ggt atc Gly Ile 1550 gat gac atc Asp Asp Ile cag gtt gaa Gin Val Glu 1555 4771 tcc ctg acc Ser Leu Thr 156C atg ctg gac Met Leu Asp 1575 ggc ttc ggt qac Gly Phe Gly Asp atg aac Met Asn 1565 gcc acc gca Ala Thr Ala gac acc cag gca Asp Thr Gin Ala 1570 4819 4867 aag ggc atc Lys Gly Ile gac cca cgc ttc atc Asp Pro Arq Phe Ile 1580 tcc cqc Ser Arg 1585 gca aac gat Ala Asn Asp cga cgt cgc gca ggc Arg Arg Arg Ala Gly 1590 ttc ctc gaa gca gca Phe Leu Gin Ala Ala 1595 ggt ggc ggt Gly Gly Gly 1600 acc gtc ctc 4915 Thr Val Leu 1605 ctg gca cgt gca Len Ala Arq Ala tcc gtt gct gct gaa ctg gga ctg cca gtt Ser Val Ala Ala Gin Len Gly Len Pro Val 1610 1615 ctc gca Len Ala 1620 4963 gtt gtt gca cac gca cag tcc tac gcc gat ggt gct cac acc tcc atc 5011 Val Val Ala His Ala Gin Ser Tyr Ala Asp Gly Ala His Thr Ser Ile 1625 1625 1630 13 1635 oca gca ccg gga ott. ggc gca ctg ggt Pro Ala Pro Gly Leu Gly Ala Leu Gly 1640 1645 goa gca cgt ggt ggo aag aag Ala Ala Arg Gly Gly Lys Lys 1650 5059 5107 toc gta ctt got cgc gaa ctg aac aaa ttg ggt ctg acc cca gat gao Ser Val Leu Ala Arg Gin Leu Asn Lys Leu Gly Len Thr Pro Asp Asp 1655 1660 1665 gtt ogc Val Arg 1670 gtg gtc tcg aag cac Val Val Ser Lys His 1675 gao acc tcc aoc aac Asp Thr Ser Thr Asn 1680 gcc aao gat cca Ala Asn Asp Pro 5155 1685 5203 aac gag tcc gag Asn Giu Ser Gin ctg cac Leu His 1690 aac otg ctg Asn Leu Leu tgg aag Trp Lys 1695 acc att gga Thr Ile Gly ego gaa Arg Giu 1700 gcc gao aac Ala Asp Asn cog atg Pro Met 1705 tto gto gto Phe Val Val tco cag Ser Gin 1710 aag too ott Lys Ser Leu ace gga eac Thr Gly His 1715 5251 5299 toa aag ggo ggt Ser Lys Gly Gly 1720 gca gca oto Ala Ala Leu ttc cag Phe Gin 1725 ato ggt gga Ile Gly Gly ott gtc too ato Len Val Ser Ile 1730 otg gaa Leu Giu 1735 cca gag Pro Giu 1750 aco ggc aag ctg rhr Gly Lys Leu oca cag Pro Gin 1740 aae gca too Asn Ala Ser Ott gac Len Asp 1745 tgo gtt gao Cys Val Asp atg gaa gca M1et Glu Ala aag ggo Lys Gly 1755 gag aac ttc Glu Asn Phe gto tgg Val Trp 1760 otg ogo aag ooa Len Arg Lys Pro 5347 5395 1765 5443 otg gat oto Len Asp Leu ggo tto ggo Gly Phe Gly ggo goa ggo too att aag Gly Ala Gly Ser Ile Lys 1770 gcc ggc Ala Gly 1775 gta ott acc toa Val Leu Thr Ser 1 ctg Len 780 cac gtg His Val 1785 got gca gto gto gtg Ala Ala Val Val Val 1790 otg goa ace Len Ala Thr ago ggc ato Ser Gly Ile 1795 5491 too gag cag goa atg ogo aao Phe Gin Gin Ala Met Arg Asn 1800 gea ggo Ala Gly 1805 oto gao gto Len Asp Val gaa goa tgg ogt Gin Ala Trp Arg 1810 5539 gea ego goa Ala Arg Ala 1815 aco cag ogo Thr Gin Arg otg cge Len Arg 1820 aco ggt goa Thr Gly Ala aao ogo Asn Arg 1825 eta gaa got 5587 Len Gin Ala gga ogt ego 5635 Gly Arg Arg 1845 ggo atg gtt ggo oga Gly Met Val Gly Arg 1830 goa oca ttg Ala Pro Leu 1835 tto gag oag gto gao Phe Gin Gin Val Asp 1840 otg oca gag oat ggo got oao caa goa Len Pro Gin His Gly Ala His Gin Ala 1850 got gao got ogo oto ggt got gao ggc Ala Asp Ala Arg Leu Gly Ala Asp Gly 1865 18 gag ato aao ttg ott ato gao Gin Ile Asn Len Len Ile Asp 1855 1860 ato tao cag ggo taaaogttag Ile Tyr Gin Gly 5683 5732 atagctaaga aag 5745 <210> 46 <211> 1874 <212> PRT <213> Corynebacterium glutamicum <400> 46 Val Arg Ile Val Leu Thr Thr Glu Gly Glu Val Ala Ala Lys Leu Val 1 5 10 Thr Arg Phe Ala Ile Arg Gly Arg Ile Thr Thr Asn Glu Met Ala Ala 25 Pro Ala Asp Ser Tyr Gly Ala Arg Asp Glu Val Val Glu Ala Thr Pro 40 Arg Ser Phe Ile Arg Gin Ala Thr Val Ser Ala Pro Ala Asp Met Thr 55 Pro Phe Ala Met Val Ser Gly Asp Tyr Asn Pro Ile His Thr Ser Asp 70 75 Asn Ala Ala Lys Leu Val Gly Leu Asp Ala Ala Leu Val His Gly Met 90 Trp Leu Ser Ala Thr Ala Gin His Leu Ala Gly Leu Gly Ser Glu Val 100 105 110 Ile Gly Trp Thr Tyr Ser Met Tyr Gly Met Val Gin Leu Asn Asp Val 115 120 125 Val Asp Ile Thr Val Glu Arg Val Gly Arg Ala Gly Leu Lys Pro Ala 130 135 140 Tyr Glu Val Thr Cys Arg Ile Asp Gly Asn Val Val Ser Arg Gly Gin 145 150 155 160 Ala Leu Leu Lys Ala Pro Ser Thr Ala Tyr Val Tyr Pro Ser Gin Gly 165 170 175 Ile Gin Ala Lys Gly Met Gly Gin Gly Asp Arg Thr Ala Ser Ala Glu 180 185 190 Ala Arg Ala Val Trp Glu Arg Ala Asp Ala His Thr Arg Ala Asn Leu 195 200 205 Gly Phe Ser Ile Gin Gin Val Ile Asp Glu Asn Pro Thr Glu Leu Lys 210 215 220 Val Gly Asp Thr Thr Phe Val His Pro Ala Gly Val Leu Asn Leu Thr 225 230 235 240 Gin Phe Thr Gin Val Ala Leu Ala Val Val Ala Tyr Ala Gin Thr Glu 245 250 255 Arg Leu Lys Ala Ala Asn Ala Ile Val Asp Gly Ser Leu Tyr Ala Gly 260 265 270 His Ser Leu Gly Glu Tyr Thr Ala Leu Ala Ser Leu Gly Asn Ile Phe 275 280 285 Glu His 305 Ala As n Val Ala Tyr 385 Arg Glu Val1 Ala Asp 465 Gln Asp Leu Pro Val1 545 Ala Ala Leu 290 Ser Al a T rp As n Gi y 370 Val Pro Thr Ala Val1 450 Glu Phe Thr Thr Val1 530 Arg Pro Pro Gly Val1 Arg Asp 340 As n Lys Ile Val1 Asp 420 Pro Pro Thr Ser Asp 500 Leu As n Ala Ala Al a Val1 Pro Pro 325 Arg Val1 Ala Pro Pro 405 Ile Phe Ser Leu Pro 485 Gin Ala Val1 Pro Ala 565 Al a Ile Arg 310 Asn Val Asp Leu GJly 390 Ala Asp Glu Glu Al a 470 ValI Ile Leu Glu Val1 550 Al a Al a Asp 295 Asp Met Ala Gly Lys 375 Ile Phe Ala Leu Arg 455 Arg Arg Ile Arg Arq 535 Ala Ala Al a ValI Glu Ile Glu Gin 360 Al a Asp Ala Leu Thr 440 Leu Leu Trp Giu Thr 520 Asp Giu Pro Pro Val Phe Lys Gly Asn Val 330 Glu Ser 345 Gin Tyr Ser Ala Vai Pro Glu Lys 410 Arg Gly 425 Gin Ser Lys Gly Leu Leu Ile Glu 490 Val Gly 505 Met Asp Gin Asp Val Giu Ala Ala 570 Ala Pro 585 Ile Met Arg 300 Ser Al a Glu Val1 Al a 380 His Asp Tyr ValI Lys 460 Glu Gin Al a Ile Val1 540 Giu Al a Gly Leu Gly As n Thr Phe Ala 365 Asn Se r Giu Ile Asp 445 Val1 Le u Al a Al a Gly 525 Met Ala Pro Asn Phe Ala Gly Val1 335 Gin Thr Arg Val Leu 415 Asn Ile Asp Ser Ile 495 Pro Ser As n Giu Ala 575 Pro Val Met Le u 320 Glu Ile Le u Al a Leu 400 Pro Leu Le u Th r Trp 480 Ile Thr Arg Asp Glu 560 Al a Glu Gin 580 Leu Lys Phe Asn Ala Ala Asn Ala Asn Leu 625 Ser Val Pro Leu Thr 705 Glu Leu Leu Val Ser 785 Val1 Thr Ala Val1 Al a 865 Glu Trp ValI Lys 610 Thr Thr Ala Phe Thr 690 Gl y be u Gly Ile Se r 770 Ala Leu Lys Val1 Phe 850 Arg Arg Ala Ser Ile Asn Asn Gly Glu Leu Thr Leu 660 Gly Pro 675 Gly Ala Thr Trp Leu Leu Ser Leu 740 Asp Ala 755 Met Ser Ala Leu Ala Asn Asp Glu 820 Glu Ala 835 Ser Ala Glu Asp Phe Ala Glu His 900 Glu Val 915 Ile Val1 Ser 645 Gln Val1 Ala Gly Gly 725 Pro Al a Ser Asp Val1 805 Val1 Glu Asp Leu Gly 885 Val1 Al a Asp Ser 630 Val1 Gly Le u Gi y Leu 710 Th r Al a Val1 Gl y Ala 790 Al a Gi u Leu Arg Al a 870 Trr Glu Al a Gln 615 Ser Pro Arg Ser Leu 695 Pro Arg Asn Gln Gly 775 Tyr Ar g Gly Gly Ala 855 Arg Gly Asp Lys Ile Arg Thr Val1 Glu 680 Lys Glu Glu Al a As n 760 Al a Al a Gly Al a Thr 840 Ile Leu Glu Thr Pro 920 Thr Arg Ile Va i 665 Thr Thr Ser Gly Ser 745 Val1 Al a Ser Ile Glu 825 Gly Le u Al a Thr Al a 905 Al a Ala As n Asp 650 Thr Val1 Ser Trp Giu 730 Ser Ala Ser Thr Leu 810 Ile Trp Phe Asn Val1 890 Leu Asn Ala Gin 635 Gly Al a Arg T yr Thr 715 Ser Lys Al a Gl y Val1 795 Ser Asp be u Asp Gly 875 Val1 Ala Glu Asp 620 Met Al a Al a Al a Ile 700 Ala Val1 Gly Ala Gly 780 Thr Gin Thr Lys Asp 860 Glu Lys Aila Pro Thr Ser Leu Met Ala Asp Pro Gly 670 Arg Leu 685 Gly Asp His Val Arg Gly Asp Val 750 Asn Gly 765 Gly Val Gly Glu Leu Gly Glu Leu 830 Leu Val 845 Arg Trp Asp Ile Gin Ala Thr Leu 910 His Ile 925 Glu Asp Ala 655 T yr Arg Arg Glu Gly 735 Asp Thr Val1 Glu Leu 815 Tyr Th r Al a Al a Al a 895 Lys Asp Thr Met 640 Asp Lys Al a Val1 Val1 720 As n Al a Ser Asp Gly 800 Asp Asp Pro Ser Val1 880 Trp Gln Asp Val. Ala Leu Val Thr Gly Ala Ala Pro Glu Ser Ile Ala Gly Ala Val 930 935 940 Ala Ala Arg Leu Leu Ser Gin Giy Ala Thr Val Ile Leu Thr Ala Ser 945 950 955 960 Asn Val. Ser Gin Ala Arg Lys Glu Tyr Ala Arg Lys Leu Tyr Ala Ala 965 970 975 Asn Ala Thr Pro Asn Ala Lys Leu Trp Ile Val Pro Ala Asn Met Ser 980 985 990 Ser Tyr Arg Asp Val Asp Ala Val Ile Asp Trp Ile Gly Asn Giu Gin 995 1000 1005 Arg Val Thr Val Gly Ser Thr Val Thr Val Thr Lys Pro Ala Leu Thr 1010 1015 1020 Pro Thr Leu Ala Tyr Pro Phe Ala Ala Pro Ser Val Ser Gly Thr Leu 1025 1030 1035 1040 Ala Asp Ala Gly Pro Gin Ala Glu Asn Gin Ala Arg Leu Leu Leu Trp 1045 1050 1055 Ser Val Giu Arg Thr Ile Ala Gly Leu Ala Asp Leu Ala Ser Arg Gly 1060 1065 1070 Val Asp Gly Arg Val His Val Val Leu Pro Gly Ser Pro Asn Arg Gly 1075 1080 1085 Met Phe Gly Gly Asp Gly Ala Tyr Gly Giu Val Lys Ala Ala Phe Asp 1090 1095 1100 Ala Ile Leu Ala Lys Trp Giy Ser Giu Thr Gly Trp Pro Gin Phe Val. 1105 1110 1115 1120 Ser Leu Ala Gin Ala Arg Ile Gly Trp Val. Ala Gly Thr Gly Leu Met 1125 1130 1135 Gly Arg Asn Asp Val Leu Ile Pro Ala Ala Giu Lys Leu Gly Ile His 1140 1145 1150 Val Tyr Thr Pro Glu Giu Ile Ser Ser Giu Leu Leu Gly Leu Ala Ser 1155 1160 1165 Ala Giu Ser Arg Giu Lys Ala Leu Giu Ala Pro Ile Asp Tyr Asp Leu 1170 1175 1180 Thr Gly Gly Leu Ser Gly Gly Val Ser Ile Ala Ala Leu Ala Ala Ser 1185 1190 1195 1200 Leu Giu Ser Asp Ala Val Glu Thr Thr Ser Ala Ala Giu Asp Thr Ile 1205 1210 1215 Lys Ala Leu Pro Ser Pro Lys His Pro Giu Gin Pro Val Gly Thr Pro 1220 1225 1230 Val Gly Giu Val Lys Thr Asp Leu Giu Asp Met Val Val Met Val Gly 1235 1240 1245 Val Gly Glu Val Ser Ser Trp Gly Ser Gly Arg Thr Arg Phe Glu Ala 1250 1255 1260 Glu Tyr Gly Ile Gin Arg Asp Gly Ser Val Asp Leu Thr Ala Ala Gly 1265 1270 1275 1280 Val Leu Glu Leu Ala Trp Met Met Gly Leu Ile Ser Trp Ser Glu Asp 1285 1290 1295 Pro Lys Pro Ala Trp Tyr Asp Ala Asp Gly Thr Glu Val Pro Glu Glu 1300 1305 1310 Glu Ile Tyr Glu Arg Phe Arg Asp Glu Val Ile Ala Arg Cys Gly Val 1315 1320 1325 Arg Glu Leu Val Asp Asp Ala Phe Leu Val Asp Gly Gly Ser Leu Asp 1330 1335 1340 Ala Ala Glu Val Phe Leu Asp Arg Asp Ile Ser Phe Ser Val Thr Ser 1345 1350 1355 1360 Ala Glu Glu Ala Gin Ala Tyr Val Asp Ala Asp Ala Ser Val Thr Val 1365 1370 1375 Glu Glu Ala Asp Gly Glu Trp Ile Val Thr Lys Lys Lys Gly Ser Thr 1380 1385 1390 Ser Phe Val Pro Arg Lys Ala Thr Leu Thr Arg Ser Val Ala Gly Gin 1395 1400 1405 Leu Pro Thr Asp Phe Asp Pro Ala Lys Trp Gly Ile Pro Ala Ser Met 1410 1415 1420 Ile Asp Ala Leu Asp Asn Ile Ala Ala Trp Asn Leu Val Thr Ala Val 1425 1430 1435 1440 Asp Ala Phe Leu Ser Ser Gly Phe Ser Pro Ala Glu Leu Leu Gin Ser 1445 1450 1455 Ile His Pro Ala Asp Val Ser Ser Thr Gin Gly Thr Gly Ile Gly Gly 1460 1465 1470 Met Gin Ser Leu Arg Lys Leu Phe Val Asn Arg Phe Leu Gly Gin Asp 1475 1480 1485 Arg Pro Ser Asp Ile Leu Gin Glu Thr Leu Pro Asn Val Val Ala Ala 1490 1495 1500 His Thr Met Gin Ser Tyr Val Gly Gly Tyr Gly Gin Met Ile His Pro 1505 1510 1515 1520 Val Ala Ala Cys Ala Thr Ala Ala Val Ser Val Glu Glu Gly Val Asp 1525 1530 1535 Lys Ile Arg Leu Asn Lys Ala Asp Phe Val Val Ala Gly Gly Ile Asp 1540 1545 1550 Asp Ile Gin Val Glu Ser Leu Thr Gly Phe Gly Asp Met Asn Ala Thr 1555 1560 1565 Ala Asp Thr Gin Ala Met Leu Asp Lys Gly Ile Asp Pro Arg Phe Ile 1570 1575 1580 Ser Arg Ala Asn Asp Arg Arg Arg Ala Gly Phe Leu Glu Ala Ala Gly 1585 1590 1595 1600 Gly Gly Thr Val Leu Leu Ala Arg Ala Ser Val Ala Ala Glu Leu Gly 1605 1610 1615 Leu Pro Val Leu Ala Val Val Ala His Ala Gin Ser Tyr Ala Asp Gly 1620 1625 1630 Ala His Thr Ser Ile Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala 1635 1640 1645 Arg Gly Gly Lys Lys Ser Val Leu Ala Arg Glu Leu Asn Lys Leu Gly 1650 1655 1660 Leu Thr Pro Asp Asp Val Arg Val Val Ser Lys His Asp Thr Ser Thr 1665 1670 1675 1680 Asn Ala Asn Asp Pro Asn Glu Ser Glu Leu His Asn Leu Leu Trp Lys 1685 1690 1695 Thr Ile Gly Arg Glu Ala Asp Asn Pro Met Phe Val Val Ser Gin Lys 1700 1705 1710 Ser Leu Thr Gly His Ser Lys Gly Gly Ala Ala Leu Phe Gin Ile Gly 1715 1720 1725 Gly Leu Val Ser Ile Leu Glu Thr Gly Lys Leu Pro Gin Asn Ala Ser 1730 1735 1740 Leu Asp Cys Val Asp Pro Glu Met Glu Ala Lys Gly Glu Asn Phe Val 1745 1750 1755 1760 Trp Leu Arg Lys Pro Leu Asp Leu Gly Ala Gly Ser Ile Lys Ala Gly 1765 1770 1775 Val Leu Thr Ser Leu Gly Phe Gly His Val Ala Ala Val Val Val Leu 1780 1785 1790 Ala Thr Ser Gly Ile Phe Glu Gin Ala Met Arg Asn Ala Gly Leu Asp 1795 1800 1805 Val Glu Ala Trp Arg Ala Arg Ala Thr Gin Arg Leu Arg Thr Gly Ala 1810 1815 1820 Asn Arg Leu Glu Ala Gly Met Val Gly Arg Ala Pro Leu Phe Glu Gin 1825 1830 1835 1840 Val Asp Gly Arg Arg Leu Pro Glu His Gly Ala His Gin Ala Glu Ile 1845 1850 1855 Asn Leu Leu Ile Asp Ala Asp Ala Arg Leu Gly Ala Asp Gly Ile Tyr 1860 1865 1870 Gin Gly <210> 47 <211> 3317 <212> DNA <213> Corynebacteriun glutamicum <220> <221> CDS <222> (3294) <223> FRXA00113 <400> 47 gct tca ggt ggc gga gtt gtt gat tcc gca gca ctt gat gcc tac gca 48 Ala Ser Gly Gly Gly Val Vai Asp Ser Ala Ala Leu Asp Ala Tyr Ala 1 5 10 tcc acc gtc act ggt gaa gaa ggc gtc ctg gca aac gtt gct cgc ggc 96 Ser Thr Val Thr Gly Glu Glu Gly Val Leu Ala Asn Val Ala Arg Gly 25 att ctg tct cag ctt ggt ctc gac acc aag gac gag gtt gaa ggc gca 144 Ile Leu Ser Gin Leu Gly Leu Asp Thr Lys Asp Giu Val Glu Gly Ala 40 gag atc gac acc gaa ctc tac gac gct gtc gaa gca gaa ctg ggc acc 192 Glu Ile Asp Thr Glu Leu Tyr Asp Ala Vai Glu Ala Glu Leu Gly Thr 55 ggc tgg ctg aag ctt gtc acc cca gtg ttc tcc gct gat cgt gcg atc 240 Gly Trp Leu Lys Leu Val Thr Pro Val Phe Ser Ala Asp Arg Ala Ile 70 75 ttg ttc gac gac cgt tgg gca tct gca cgt gaa gat ctg gca cgc ctt 288 Leu Phe Asp Asp Arg Trp Ala Ser Ala Arg Glu Asp Leu Ala Arg Leu 90 gcc aac ggc gag gat att gcc gtc gag cgc ttt gct gga acg ggg gag 336 Ala Asn Gly Glu Asp Ile Ala Val Glu Arg Phe Ala Gly Thr Gly Glu 100 105 110 acc gtc gtc aag caa gct gca tgg tgg gct gag cac gtt gaa gac acc 384 Thr Val Val Lys Gin Ala Ala Trp Trp Ala Glu His Val Glu Asp Thr 115 120 125 gct ctc gct gca acc ctg aag cag gtt tcc gag gtg gct gcg aag cca 432 Ala Leu Ala Ala Thr Leu Lys Gin Val Ser Glu Val Ala Ala Lys Pro 130 135 140 gcc aac gag cca cac atc gac gat gtt gcg ctg gtt acc ggt gcg got 480 Ala Asn Glu Pro His Ile Asp Asp Val Ala Leu Val Thr Gly Ala Ala 145 150 155 160 cct gag tcg atc gcc ggt gca gtt gcg gct cgc ctg ctg tcc cag ggc 528 Pro Giu Ser Ile Ala Gly Ala Val Ala Ala Arg Leu Leu Ser Gin Gly 165 170 175 gcg acc gtc att ctc acc gca tcg aac gto tco cag gcg cgt aag gaa 576 Ala Thr Val Ile Leu Thr Ala Ser Asn Val Ser Gin Ala Arg Lys Glu 180 185 190 tao gca ogo aag ctc tac got gcg aac gca acc oct aac gca aag ctg 624 Tyr Ala Arg Lys Leu Tyr Ala Ala Asn Ala Thr Pro Asn Ala Lys Leu 195 200 205 tgg att Trp lie 210 gtt cct gcg aac Val Pro Ala Asn atg Met 215 tcc tec tac cgc Ser Ser Tyr Arg ga t Asp 220 gtt gat gca gte Vai Asp Ala Val atc Ile 225 gat tgg atc gge Asp Trp Ile Gly gag cag cgc gtc Giu Gin Arg Val gtc ggc age acc Vai Gly Ser Thr 672 720 768 ace qtg acc aag Thr Vai Thr Lys gct ctg acc cca Ala Leu Thr Pro acc Thr 250 ctt gcg tac eca Leu Aia Tyr Pro tte qca Phe Ala 255 gct eca tee Ala Pro Ser aac cag gca Asn Gin Ala 275 gta Vali 260 tcc ggt acc ttg Ser Giy Thr Leu gat gca ggc cca Asp Ala Gly Pro cag gct gaa Gin Ala Giu 270 ate gca gga Ile Ala Gly 816 864 cgc ctg ctc ctc Arg Leu Leu Leu tcc gtg gag ege Ser Val Giu Arg ac Thr 285 ctt gca Leu Ala 290 gat ctt gca tc Asp Leu Ala Ser cge Arg 295 ggt gtc gat gga Gly Val Asp Gly gtc cac gtt gta Vai His Val Val ct c Leu 305 cca qgt tce ccg Pro Gjty Ser Pro cge gga atg ttc Arg Gly Met Phe ggc gac ggc gct Gly Asp Gly Ala ggc gaa gtc aag Gly Glu Vai Lys get ttc gac gc Ala Phe Asp Ala ate Ile 330 ett gee aag tgg Leu Ala Lys Trp ggc tcc Giy Ser 335 912 960 1008 1056 1104 gag aec ggc Glu Thr Gly tgg gtc gca Trp Vai Ala 355 cca cag ttt gte Pro Gin Phe Val etc gca cag gea Leu Ala Gin Ala cgc ate ggc Arg Ile Gly 350 cte ate cet Leu Ile Pro gge ace ggc etc Gly Thr Gly Leu ggt cgc aac gac Gly Arg Asn Asp gtg Val1 365 gee gct Ala Ala 370 gaa aag ctg ggc Giu Lys Leu Gly eac gte tac ace His Val Tyr Thr ct Pro 380 gaa gag ate tct Glu Glu Ile Ser tee Ser 385 gaa ctg ctg ggt Giu Leu Leu Giy ctt Leu 390 gca tce gca gaa Ala Ser Ala Glu cgc gaa aag get Arg Giu Lys Ala 1152 1200 1248 gaa gca ccg ate Giu Ala Pro Ile tac gae etg ace Tyr Asp Leu Thr gga ett tee ggt Gly Leu Ser Gly gge gta Gly Val 415 tee ate gca Ser Ile Ala ace tet gea Thr Ser Ala 435 etg gea gca tee Leu Ala Ala Ser etc Leu 425 gag tee gac gea Giu Ser Asp Ala gta gag ace Val Glu Thr 430 cet aag eac Pro Lys His 1296 1344 gca gaa gae ace Aia Giu Asp Thr aag gcg ett eca Lys Ala Leu Pro cca gag Pro Glu 450 cag oca gtg ggc Gin Pro Val. Gly acg Thr 455 oca gtt gga gag Pro Val Gly Gin gtc ValI 460 aag acc gat otc Lys Thr Asp Len 1392 gac atg gtt gto Asp Met Val Val gtt ggc gtt ggc Val Gly Val. Gly gtc tcc tca tgg Val Ser Ser Trp ggc Gi y 480 1440 1488 toc gga cgt acc Ser Gly Arg Thr cgo Ar g 485 ttc gaa got gag Phe Gin Ala Glu tao Tyr 490 ggc atc cag cgc Gly Ile Gin Arg gac ggc Asp Gly 495 tcc gtt gao Ser Vai*Asp ggt ctg atc Gly Leu Ile 515 aco qca gca ggc Thr Ala Ala Gly ctt. gag ctt gca Leu Gin Len Ala tgg atg atg Trp Met Met 510 tac gac got Tyr Asp Ala 1536 1584 tcc tgg agc gaa Ser Trp Ser Gin cca aag cca gc Pro Lys Pro Ala gac ggc Asp Giy 530 aco gaa gtg cot gaa gaa gag ato tac Thr Giu Val Pro Gin Gin Gin Ile Tyr 535 gag Gin 540 ogo tto ogo gao Ary Phe Arg Asp 1632 gto ato goa oga Val Ile Ala Arg ggt gtt ogt gag Gly Vai Arg Gin gto gao gao goa Val Asp Asp Ala tto Phe 560 oto gto gao ggo Len Val Asp Gly ggo Giy 565 too oto gao goa Ser Leu Asp Ala got. Ala 570 gaa gto tto oto Glu Val Phe Leu gao ogo Asp Arg 575 1680 1728 1776 1824 gao ato too Asp Ile Ser gat goa gat Asp Ala Asp 595 too gta aoo tot Ser Val Thr Ser gaa gaa goa cag Giu Glu Ala Gin goo tao gto Ala Tyr Val 590 gaa tgg ato Giu Trp Ie got too gtg aoo Ala Ser Val Thr gaa gaa goa gao Gin Giu Ala Asp gg o Gi y 605 gtg aoo Val Thr 610 aag aag aag ggo Lys Lys Lys Gly aoo too tto gtg Thr Ser Phe Val ooa Pro 620 ogo aag goa aoo Arg Lys Ala Thr aoo oqo too gta Thr Arg Ser Val g oa Ala 630 ggo oag otg ooa Gly Gin Leu Pro aoo Thr 635 gao tto gao oot Asp Phe Asp Pro 1872 1920 1968 aag tgg ggt ato Lys Trp Gly Ile goo too atg ato Ala Ser Met Ile ga t Asp 650 goa oto gao aao Ala Leu Asp Asn ato goa Ile Ala 655 gog tgg aao Ala Trp Asn ago ooa gca Ser Pro Ala 675 ot g Len 660 gte aot goa gto Val. Thr Ala Val gao Asp 665 goo tto otg too Ala Phe Len Ser too ggo tto Ser Gly Phe 670 gtg too too Val Ser Ser 2016 2064 gaa cto otg oag Gin Leu Leu Gin ato oao oca got Ile His Pro Ala ga c Asp 685 aoo oag ggo aoc ggt ato ggt ggo atg eag too eta ogo aag otg tto 11 2112 Thr Gin 690 Gly Thr Gly Ile Gly Met Gin Ser Leu 700 Arg Lys Leu Phe gtc ValI 705 aac cgc ttc ctc Asn Arg Phe Len ggc Gly 710 cag gat cgt cca Gin Asp Arq Pro gac atc ctc cag Asp Ile Leu Gin 2160 2208 acc ctg cca aac Thr Leu Pro Asn gtg gct gca cac Val Ala Ala His atg cag tcc tac Met Gin Ser Tyr gtc ggt Val Gly 735 gqc tac ggc Gly Tyr Gly gtc tcc gtg Val Ser Val 755 ca g Gin 740 atg atc cac cca Met Ile His Pro gtg Val1 745 gca gca tgt gca Ala Ala Cys Ala acc gca gct Thr Ala Ala 750 aag gca gat Lys Ala Asp 2256 2304 gaa gaa ggc gtg Glu Giu Gly Val gac Asp 760 aag atc cgc ctc Lys Ile Arg Len ttc gtt Phe Val 770 gtc gcc ggt ggt Vai Ala Gly Gly atc Ile 775 gat gac atc cag Asp Asp Ile Gin gaa tcc ctg acc Giu Ser Leu Thr ggc Gi y 785 ttc qgt gac atg Phe Gly Asp Met gcc acc gca gac Ala Thr Ala Asp cag gca atg ctg Gin Ala Met Len 2352 2400 2448 aaq qgc atc gac Lys Gly Ile Asp cgc ttc atc tcc Arg Phe Ile Ser gca aac gat cga Ala Asn Asp Arg cgt cgc Arg Arg 815 gca ggc ttc Ala Gly Phe gca tcc gtt Ala Ser Val 835 ctc Len 820 gaa gca gca ggt Gin Ala Ala Gly ggt acc gtc ctc Gly Thr Val Len ctg gca cgt Len Ala Arg 830 gtt gtt gca Val Val Ala 2496 2544 gct gct gaa ctg Ala Ala Gin Len gga Gly 840 ctg cca gtt ctc Leu Pro Val Leu cac gca His Ala 850 cag tcc tac gcc Gin Ser Tyr Ala ggt gct cac acc Gly Ala His Thr tcc Ser 860 atc cca gca ccg Ile Pro Ala Pro gga Gly 865 ctt ggc gca ctg Leu Gly Ala Len ggt Gly 870 gca gca cgt ggt Ala Ala Arg Gly ggc Gly 875 aag aag tcc gta Lys Lys Ser Val 2592 2640 2688 gct cgc gaa ctg Ala Arg Glu Len aaa ttg ggt ctg Lys Len Gly Leu cca gat gac gtt Pro Asp Asp Val cgc gtg Arg Val 895 gtc tcg aag Val Ser Lys gag ctg cac Giu Len His 915 gac acc tcc aco Asp Thr Ser Thr gcc aac gat cca Ala Asn Asp Pro aac gag tcc Asn Gin Ser 910 gcc gac aac Ala Asp Asn 2736 2784 aac ctg ctg tgg Asn Len Leu Trp sag Lys 920 acc att gga cgc Thr Ile Gly Arg ccg atg ttc gtc gtc tcc cag aag tcc ctt acc gga cac tca aag ggc Pro Met Phe Val Val Ser Gin Lys Ser Len Thr Gly His Ser Lys Gly 2832 935 940 ggt Gly 945 gca gca ctc ttc Ala Ala Leu Phe atc ggt gga ott Ile Gly Gly Leu too atc otg gaa Ser Ile Leu Giu a cc Thr 960 2880 2928 ggc aag otg cca Gly Lys Leu Pro aao gca too ctt Asn Ala Ser Leu gac Asp 970 tgc gtt gac cca Cys Val Asp Pro gag atg Glu Met 975 gaa gca aag Giu Ala Lys ggc gca ggc Gly Ala Gly 995 cac qtg got His Val Ala 1010 ggo Gly 980 gag aac ttc gtc Giu Asn Phe Val ctg cgc aag cca ctg gat ctc Leu Arg Lys Pro Leu Asp Leu 990 Ctt acc tca ctg ggc ttc ggc Leu Thr Ser Leu Gly Phe Gly 1005 tcc att aag gcc Ser Ile Lys Ala ggc gta Gly Val 1000 2976 3024 3072 goa gtc gtc Ala Val Val gtg ctg Val Leu 1015 gca acc agc Ala Thr Ser ggc atc Gly Ile 1020 ttc gag cag Phe Glu Gln gca atg cgc aac gca Ala Met Arg Asn Ala 1025 ggc ctc gac gtc gaa Gly Leu Asp Vai Glu 1030 gca tgg cgt Ala Trp Arg 1035 gca cgc gca Ala Arg Ala 3120 1040 3168 ace cag cgc otg Thr Gin Arg Leu cgc acc ggt gca aac Arg Thr Gly Ala Asn 1045 cgc cta gaa Arg Leu Glu 1050 gct ggc atg gtt Ala Gly Met Val 1055 ggc cga gca Gly Arg Ala cca ttg tto gag cag Pro Leu Phe Glu Gin 1060 gtc gac Val Asp 1065 gga cgt cgc ctg cca gag Gly Arg Arg Leu Pro Glu 1070 3216 cat ggc got cac caa gca gag atc aac ttg ctt atc gac got gac got His Gly Ala His Gin Ala Glu Ile Asn Leu Leu Ile Asp Ala Asp Ala 3264 1075 1080 1085 cgc otc ggt gct gac ggc Arg Leu Gly Ala Asp Gly 1090 atc tao cag ggc Ile Tyr Gin Gly 1095 taaacgttag atagctaaga 3314 3317 <210> 48 <211> 1098 <212> PRT <213> Corynebacterium glutamioum <400> 48 Ala Ser Gly Gly Gly Val Val Asp Ser Ala 1 5 10 Ala Leu Asp Ala Tyr Ala Ser Thr Val Thr Gly Gin Gin Gly Val 25 Ile Leu Ser Gin Leu Gly Len Asp Thr 40 Len Ala Asn Val Ala Arg Gly Gin Giy Ala Lys Asp Gin Val Glu Ile Asp Thr Giu Leu Tyr Asp Ala Val Gin Ala Giu Len Gly Thr Gly Leu Ala Thr Ala Ala 145 Pro Ala Tyr Trp Ile 225 Thr Ala Asn Leu Leu 305 Gly Glu Trp Ala Trp Phe Asn Val Leu 130 Asn Glu Thr Ala Ile 210 Asp Val Pro Gln Ala 290 Pro Glu Thr Val Ala 370 Leu Asp Gly Val 115 Ala Glu Ser Val Arg 195 Val Trp Thr Ser Ala 275 Asp Gly Val Gly Ala 355 Glu Lys Asp Glu

100. Lys Ala Pro Ile Ile 180 Lys Pro Ile Lys Val 260 Arg Leu Ser Lys Trp 340 Gly Lys Leu Arg Asp Gin Thr His Ala 165 Leu Leu Ala Gly Pro 245 Ser Leu Ala Pro Ala 325 Pro Thr Leu Val 70 Trp Ile Ala Leu Ile 150 Gly Thr Tyr Asn Asn 230 Ala Gly Leu Ser Asn 310 Ala Gin Gly Gly 55 Thr Ala Ala Ala Lys 135 Asp Ala Ala Ala Met 215 Glu Leu Thr Leu Arg 295 Arg Phe Phe Leu Ile 375 Pro Ser Val Trp 120 Gin Asp Val Ser Ala 200 Ser Gin Thr Leu Trp 280 Gly Gly Asp Val Met 360 His Val Ala Glu 105 Trp Val Val Ala Asn 185 Asn Ser Arg Pro Ala 265 Ser Val Met Ala Ser 345 Gly Val Phe Ser 75 Arg Glu 90 Arg Phe Ala Glu Ser Glu Ala Leu 155 Ala Arg 170 Val Ser Ala Thr Tyr Arg Val Thr 235 Thr Leu 250 Asp Ala Val Glu Asp Gly Phe Gly 315 Ile Leu 330 Leu Ala Arg Asn Tyr Thr Ala Asp Ala His Val 140 Val Leu Gin Pro Asp 220 Val Ala Gly Arg Arg 300 Gly Ala Gln Asp Pro 380 Asp Leu Gly Val 125 Ala Thr Leu Ala Asn 205 Val Gly Tyr Pro Thr 285 Val Asp Lys Ala Val 365 Glu Arg Ala Thr 110 Glu Ala Gly Ser Arg 190 Ala Asp Ser Pro' Gin 270 Ile His Gly Trp Arg 350 Leu Glu Ala Ile Arg Leu Gly Glu Asp Thr Lys Pro Ala Ala 160 Gin Gly 175 Lys Glu Lys Leu Ala Val Thr Val 240 Phe Ala 255 Ala Glu Ala Gly Val Val Ala Tyr 320 Gly Ser 335 Ile Gly Ile Pro Ile Ser Ser Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu Lys Ala Leu 385 Glu Ser Thr Pro Glu 465 Ser Ser Gly Asp Glu 545 Leu Asp Asp Val Leu 625 Lys Ala Ser 390 395 400 Ala Ile Ser Glu 450 Asp Gly Val Leu Gly 530 Val Val Ile Ala Thr 610 Thr Trp Trp Pro Pro Ala Ala 435 Gin Met Arg Asp Ile 515 Thr Ile Asp Ser Asp 595 Lys Arg Gly Asn Ala Ile Ala 420 Ala Pro Val Thr Leu 500 Ser Glu Ala Gly Phe 580 Ala Lys Ser Ile Leu 660 Glu Asp 405 Leu Glu Val Val Arg 485 Thr Trp Val Arg Gly 565 Ser Ser Lys Val Pro 645 Val Leu Tyr Ala Asp Gly Met 470 Phe Ala Ser Pro Cys 550 Ser Val Val Gly Ala 630 Ala Thr Leu Asp Ala Thr Thr 455 Val Glu Ala Glu Glu 535 Gly Leu Thr Thr Ser 615 Gly Ser Ala Gin Gly 695 Leu Ser Ile 440 Pro Gly Ala Gly Asp 520 Glu Val Asp Ser Val 600 Thr Gin Met Val Ser 680 Thr Leu 425 Lys Val Val Glu Val 505 Pro Glu Arg Ala Ala

585. Glu Ser Leu Ile Asp 665 Ile Gly Ser Leu Glu Glu 475 Gly Glu Pro Tyr Leu 555 Glu Glu Ala Val Thr 635 Ala Phe Pro Leu Asp Pro Val 460 Val Ile Leu Ala Glu 540 Val Val Ala Asp Pro 620 Asp Leu Leu Ala Ser Ala Ser 445 Lys Ser Gin Ala Trp 525 Arg Asp Phe Gin Gly 605 Arg Phe Asp Ser Asp 685 Gly Val 430 Pro Thr Ser Arg Trp 510 Tyr Phe Asp Leu Ala 590 Glu Lys Asp Asn Ser 670 Val Gly 415 Glu Lys Asp Trp Asp 495 Met Asp Arg Ala Asp 575 Tyr Trp Ala Pro Ile 655 Gly Ser Val Thr His Leu Gly 480 Gly Met Ala Asp Phe 560 Arg Val Ile Thr Ala 640 Ala Phe Ser 675 Thr Gin Gly Thr Gly Ile 690 Gly Met Gin Ser Leu Arg Lys Leu Phe 700 Val Asn Arg Phe Leu 705 Thr Gly Val Phe Gly 785 Lys Ala Ala His Gly 865 Ala Val Glu Pro Gly 945 Gly Glu Gly His Ala Leu Pro Tyr Gly Ser Val 755 Val Val 770 Phe Gly Gly Ile Gly Phe Ser Val 835 Ala Gin 850 Leu Gly Arg Glu Ser Lys Leu His 915 Met Phe 930 Ala Ala Lys Leu Ala Lys Ala Gly 995 Val Ala 1010 Met Arg Asn Gin 740 Glu Ala Asp Asp Leu 820 Ala Ser Ala Leu His 900 Asn Val Leu Pro Gly 980 Ser Ala Asn Val 725 Met Glu Gly Met Pro 805 Glu Ala Tyr Leu Asn 885 Asp Leu Val Phe Gin 965 Glu Ile Val Ala Gly 710 Val Ile Gly Gly Asn 790 Arg Ala Glu Ala Gly 870 Lys Thr Leu Ser Gin 950 Asn Asn Lys Val Gly Ala Ala His His Pro Val 745 Val Asp Lys 760 Ile Asp Asp 775 Ala Thr Ala Phe Ile Ser Ala Gly Gly 825 Leu Gly Leu 840 Asp Gly Ala 855 Ala Ala Arg Leu Gly Leu Ser Thr Asn 905 Trp Lys Thr 920 Gin Lys Ser 935 Ile Gly Gly Ala Ser Leu Phe Val Trp 985 Ala Gly Val 1000 Val Leu Ala 1015 Leu Asp Val Gin Asp Arg Pro Ser Asp Ile Leu Gin Glu Thr 730 Ala Ile Ile Asp Arg 810 Gly Pro His Gly Thr 890 Ala Ile Leu Leu Asp 970 Leu Leu Thr Glu Met Ala Arg Gin Thr 795 Ala Thr Val Thr Gly 875 Pro Asn Gly Thr Val 955 Cys Arg Thr Ser Ala Gin Ser Tyr Cys Ala Thr 750 Leu Asn Lys 765 Val Glu Ser 780 Gin Ala Met Asn Asp Arg Val Leu Leu 830 Leu Ala Val 845 Ser Ile Pro 860 Lys Lys Ser Asp Asp Val Asp Pro Asn 910 Arg Glu Ala 925 Gly His Ser 940 Ser Ile Leu Val Asp Pro Lys Pro Leu 990 Ser Leu Gly 1005 Gly Ile Phe 1020 Trp Arg Ala Val 735 Ala Ala Leu Leu Arg 815 Ala Val Ala Val Arg 895 Glu Asp Lys Glu Glu 975 Asp Phe Glu Arg 720 Gly Ala Asp Thr Asp 800 Arg Arg Ala Pro Leu 880 Val Ser Asn Gly Thr 960 Met Leu Gly Gin Ala 1025 1030 1035 Thr Gin Arg Leu Arg Thr Gly Ala Asn Arg Leu Glu Ala Gly Met Val 1045 1050 1055 Gly Arg Ala Pro Leu Phe Giu Gin Vai Asp Gly Arq Arg Leu Pro Glu 1060 1065 1070 His Gly Ala His Gin Ala Glu Ile Asn Leu Leu Ile Asp Ala Asp Ala 1075 1080 1085 Arg Leu Gly Ala Asp Gly Ile Tyr Gin Gly 1090 10'95 <210> 49 <211> 6136 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(6136) <223> RXN03111 <400> 49 cgtgaccgaa ttgagcagga acttcggggc cagccgactg attaaccgct ttggccag gccttttgcc ttcgctttcg ccggccaagg atatgactgg ttg aag acc ctt cgt 1040 ~a Leu Lys Thr Leu gcc Ala cgc Arg ctt Leu cca Pro gtc Val1 gtg Vai gtg Val gcg gcg Ala gca Al a cca Pro gct Al a tcc Se r ga t Asp cac His cag gcc Al a gcg Al a ggt Gi y ga t Asp atc Ile gct Al a ct C Leu 105 atc ggt Gly ctt Le u ga t Asp gca Ala acc Thr 75 t cc Ser gat Asp gca ggc Gly cta Le u gtg Val1 tct Ser ga t Asp att Ile act Thr atc a cc Thr gtt Val1 30 gct Ala gca Ala t cc Ser ggt Gly cgt Arg 110 acc gtt Val1 gat Asp gct Ala agc Ser gag Glu 80 t cc Ser gat Asp a cc I agt Ser ga t Asp aac As n gtg Val1 gcg Al a cag Gin ga a Glu gca atc Ile att Ile tcc Se r ggt Gi y cgc Arg gt a Val1 gtt Val1 115 at g Ar g gag Giu acc Th r ga t Asp ttt Ph e ga t Asp ggc Gi y att Ile ggc Ala Gin Leu 120 Ile Gly Ala Ala Ile Thr Arg Thr Ala Met Thr Gly otg atc Leu Ile 135 gog cag ggc gao Ala Gin Gly Asp aac Asn 140 atg ccg atg ctg Met Pro Met Leu tog Ser 145 atc gcc gga att Ile Ala Gly Ile cgc gaa cag ctt Arg Glu Gin Leu caa got atc gac Gin Ala Ile Asp gcc tgc gcc gaa Ala Cys Ala Glu oct gog gag ato Pro Ala Glu Ile cg o Arg 170 cog gtt atc ggt Pro Val Ile Gly otg Leu 175 ego aac tca cgc Arg Asn Ser Arg gat tot Asp Ser 180 tat gtt ttg Tyr Val Leu att gag goa Ile Glu Ala 200 ggc cgc cca gao Gly Arg Pro Asp gao Asp 190 aao got ogo gtt Asn Ala Arg Val gtt aag gtc Val Lys Val 195 gat aag otg Asp Lys Leu atg got goo aag Met Ala Ala Lys aag aag goc att Lys Lys Ala Ile cgc ggc Arg Gly 215 ggt too gog ttc Gly Ser Ala Phe coo cqt att act Pro Arg Ile Thr cg Pro 225 otg aag gtg oag Leu Lys Val Gin got tto cat cac Ala Phe His His oca Pro 235 got atg aac atg Ala Met Asn Met gtg gag cag aco Val Glu Gin Thr geg tgg gea ace Ala Trp Ala Thr act Thr 250 got ggt ttg gat Ala Gly Leu Asp gaa etc acc cge Glu Leu Thr Arg gag ate Glu Ile 260 gco got gat Ala Ala Asp gaa gog tat Glu Ala Tyr 280 ttg gtt aac cct Leu Val Asn Pro gte Val1 270 gat tgg gta gca Asp Trp Val Ala ogo gte aac Arg Val Asn 275 gga oca gat Gly Pro Asp gag got ggo got Giu Ala Gly Ala tgg tto oto gao Trp Phe Leu Asp ggt ggc Gly Gly 295 ato gtt aag otg Ile Val Lys Leu act Thr 300 goc aac ato ott Ala Asn Ile Leu gag Glu 305 ggo ogo ggo gog Gly Arg Gly Ala ga t Asp 310 too ttc tat gtt Ser Phe Tyr Val gao gco gca gge Asp Ala Ala Gly gee aag ata ttt Ala Lys Ile Phe gat Asp 325 cca Pro 1027 1075 1123 get ggc atg gca Ala Gly Met Ala oct Pro 330 gaa ott oca gtg Giu Leu Pro Val ga t Asp 335 tao cag gag tto Tyr Gin Glu Phe ogo gtt gag Arg Val Giu cac His 345 gtt gat qga ace Val Asp Gly Thr egc etg gtt aco Arg Leu Val Thr aag tto act Lys Phe Thr 355 1171 gag ctg aco ggc ego ace oca atg atg ctg got ggc atg aco oca ace Glu Leu Thr Gly Arg Thr Pro Met Met Leu. Ala Gly Met Thr Pro Thr 1219 365 ace gtt Thr Val 375 gac ect gee att Asp Pro Ala Ile gca gcc get yea Ala Ala Ala Ala gyt gga cac tgg Gly Gly His Trp get Al a 390 gag cte gct ggt Gin Len Ala Gly ggc Gly 395 gga cay gtt ac Gly Gin Vai Thr gag ctg etg gaa Glu Len Leu Giu ac Thr 405 1267 1315 1363 eac atc gca cay His Ile Ala Gin acc gac aty ctt Thr Asp Met Leu cca ygt atc aac Pro Gly Ile Asn gcc cag Ala Gin 420 ttc aac tcc Phe Asn Ser ggc aag cge Giy Lys Arg 440 ttc ttg qat oca Phe Leu Asp Pro t ac T yr 430 ctg tgg aag atg Leu Trp Lys Met cag att ggt Gin Ile Gly 435 tcc atc gac Ser Ile Asp 1411 1459 ett gtt cet aag Len Val Pro Lys ege get aat ggt Ary Ala Asn Gly ggc atc Gly Ile 455 gtc atc ace gcc Vai Ile Thr Ala gc Gly 460 att ect gaa aag Ile Pro Glu Lys gat Asp 465 gaa get gtt yea Gin Ala Val Ala gte aag gaa etg Val Lys Gin Len cgt gat gyt tte Arg Asp Gly Phe ct Pro 480 tgg ate yea ttc Trp Ile Ala Phe eca gyt gcc atc Pro Gly Ala Ile cag ytt aae tet Gln Val Asn Ser ttg get ate get Leu Ala Ile Ala aag gaa Lys Glu 500 gtt eea gaa Val Pro Giu yya cac eac Gly His His 520 etc Len 505 eec ate ate att, Pro Ile Ile Ile cag Gin 510 att gag qyt gge Ile Giu Gly Gly gtt yea ggt Val Ala Gly 515 gee ace tae Ala Thr Tyr 1507 1555 1603 1651 1699 1747 1795 1843 teL tyg gaa gac Ser Trp Gin Asp gat gag ety ety Asp Gin Len Len ge aag Gly Lys 535 gte eye yea ety Val Ary Ala Len ga t Asp 540 aae ytg gty ety Asn Val Val Len t yt Cys 545 gte gyc gyt yye Val Gly Gly Giy att Ile 550 gye tea cet gag Gly Ser Pro Gin yet get gat tae Ala Aia Asp Tyr gte Val1 560 ace gyt tee tg Thr Giy Ser Trp tee Se r 565 aet tee tac gyc Thr Ser Tyr Gly eca get aty cet Pro Ala Met Pro gat gyc ate ttg Asp Giy Ile Len ytg gyt Val Gly 580 ace get geg Thr Ala Ala yaa ctt ett Gin Len Len 600 yea aec aay gaa Ala Thr Lys Gin yea Ala 590 ace ace tee cay Thr Thr Ser Gin gee gte aag Ala Val Lys 595 cet yet gyt Pro Ala Gly 1891 1939 gtt tee ace cay Val Ser Thr Gin teL gat gaa tg Ser Asp Gin Trp ggc gca Gly Ala 615 aag aac gga atg Lys Asn Gly Met tct ggc cgt tcc Ser Gly Arg Ser cag Gin 625 cit ggc gca gac Leu Gly Ala Asp cac gag atc gac His Glu Ile Asp icc itt gct aag Ser Phe Ala Lys gga cgc cti ctt Gly Arg Leu Leu 1987 2035 2083 gag git gca ggc Glu Val Ala Gly gat Asp 650 gag acg gct gig Glu Thr Ala Val ca g Gin 655 gcg cgc cgg gat Ala Arg Arg Asp gag aic Giu Ile 660 att gaa gcg Ile Giu Ala icc atg act Ser Met Thr 680 ggc aag acc gcc Gly Lys Thr Ala gig tac tic Val Tyr Phe ggi gac aic gga Gly Asp Ile Gly 675 gag ctg ict ggc Glu .Leu Ser Gly 690 2131 2179 tac gag cag igg Tyr Giu Gin Trp aac cgc tac cic Asn Arg Tyr Leu cci gt Pro Vai 695 gat ggt cag tgg Asp Gly Gin Trp gat gct icc tgg Asp Ala Ser Trp gca cgi iii gcc Ala Arg Phe Ala atg ctg gag cqt Met Leu Glu Arg gag gcg cgt ttg Glu Ala Arg Leu aic Ile 720 gag cag gat cat Giu Gin Asp His caa iii gag cca Gin Phe Glu Pro agc Ser 730 cig acg gig gag Leu Thr Val Giu ggc gic gac aag Gly Val Asp Lys cti gt Leu Val '74 0 gci gci tac Ala Ala Tyr gcc igg tic Ala Trp Phe 760 cat gcc gca acc His Ala Ala Thr gac Asp 750 cig cic acc ccg Leu Leu Thr Pro gci gat gic Ala Asp Val 755 gig aac ttt Val Asn Phe 2227 2275 2323 2371 2419 2467 2515 2563 tig ggc cig igc Leu Gly Leu Cys cg c Arg 765 acg ccg ggc aag Thr Pro Gly Lys cci Pro 770 gig ccc Val Pro 775 gic sit gat sag Val Ile Asp Lys gig cgi cgc igg Val Arg Arg Trp cgc tcg gac icc Arg Ser Asp Ser tgg cag icc cac Trp Gin Ser His gat cgc tac acc Asp Arg Tyr Thr gat cag gig gci Asp Gin Val Ala sic cci ggt gic Ile Pro Gly Val gic Val1 810 gcc git gci ggc Ala Val Ala Gly scc aag gcc sac Thr Lys Ala Asn gas cci Giu Pro 820 gic gci gac Val Ala Asp gat gag csc Asp Glu His 840 cit gat cgc ttt Leu Asp Arg Phe gic Val 830 gac gcc acc aic Asp Ala Thr Ile gag cgc atc Giu Arg Ile 835 gig cii icc Val Leu Ser 2611 2659 gat icc cgc icc Asp Ser Arg Ser cgc Arg 845 gac sic aig ggc Asp Ile Met Gly tca cct Ser Pro 855 ggc aca ttc tgg Gly Thr Phe Trp get Ala 860 ggc cgc aac atc Gly Arg Asn Ile cca Pro 865 tcq gtg atc cac Ser Val Ile His agc Ser 870 ctt ggg cat gct Leu Gly His Ala aag tgg tcc ogc Lys Trp Ser Arg gaa ttc gaa gca Glu Phe Glu Ala 2707 2755 2803 cat agc cca aCC His Ser Pro Thr ggc Gly 890 gcc aac ttg gtg Ala Asn Leu Val tac T yr 895 gaa gac gcc gag Glu Asp Ala Glu cac gcg His Ala 900 atg etg act Met Leu Thr gag ctg aaa Glu Leu Lys 920 cet ttg gcg ggt Pro Leu Ala Gly acc gca ttc ggc Thr Ala Phe Gly acc aec gct Thr Thr Ala 915 cca agc gct. Pro Ser Ala 2851 2899 atc cgt ttc acc Ile Arg Phe Thr agc Ser 925 ccc ate gac gct Pro Ile Asp Ala gtc cca Val Pro 935 etg gte acc cag Leu Val Thr Gin gac gct gaa gcc Asp Ala Giu Ala atg ggt gaa ctq Met Gly Glu Leu ace Thr 950 cgc atc gca get Arg Ile Ala Ala ggc Gly 955 ggc acc ctg gca Gly Thr Leu Ala gtg aac aat ggc Val Asn Asn Gly acc Thr 965 get ace tgg gaa Ala Thr Trp Giu tcc gtc gat gcc Ser Val Asp Ala ggc Gly 975 gtc atc gct gac Val Ile Ala Asp tac aac Tyr Asn 980 2947 2995 3043 3091 3139 aac gtc acc Asn Val Thr ggc tac ctg cca Gly Tyr Leu Pro tcc gtt gtt ect gca cac ace Ser Val Val Pro Ala His Thr 995 tgq cca qca gtt ttc gct gee Trp Pro Ala Val Phe Ala Ala 1010 gca cct gac gtg Ala Pro Asp Val 1000 ctg gtt ggc Leu Val Gly cgc gca Arg Ala 1005 gta aag Val Lys 1015 ggc atg Gly Met 1030 tcc qca gtc atc Ser Ala Val Ile cca ggc Pro Gly 1020 acc gat tee Thr Asp Ser gca tee Ala Ser 1025 gtt gtg gaa Val Val Glu ctg tce etg Leu Ser Leu gtt cac Val His 1035 ctg gag cac Leu Glu His cac att His Ile 1040 gtg etc aag tcc Val Leu Lys Ser 3187 3235 1045 3283 gat gte eca ace Asp Val Pro Thr gac ge geg ctg aag Asp Gly Ala Leu Lys 1050 gtt tcc Val Ser 1055 geg act gcc Ala Thr Ala gat gag Asp Glu 1060 gta gtc gat Val Val Asp ace gac ctg ggt cgc Thr Asp Leu Gly Arg 1065 etc gtg Leu Val 1070 ate gtg ege Ile Val Arg gca gaa ate Ala Glu Ile 1075 3331 gee gac: gea gaa gge aac ctg att get aeg ttg get gag egt ttc geg Ala Asp Ala Glu Gly Asn Leu Ile Ala Thr Leu Ala Glu Arg Phe Ala 3379 1080 1085 1090 atc cgc gga egc aag ggc aac get gte gea ege ace aac ace tee gca 3427 Ile Arg Gly Arq Lys Gly Asn Ala Val Ala Arg Thr Asn Thr Ser Ala 1095 1100 1105 ctg coa acc acc gtg gac acc cca cgc tea gct cgc gca gtg gca acc 3475 Leu Pro Thr Thr Val Asp Thr Pro Arg Ser Ala Arg Ala Val Ala Thr 1110 1115 1120 1125 gtt gtt gca cct gaa tcc atg cgc cca ttc gct gtg atc tco ggt gac 3523 Val Val Ala Pro Giu Ser Met Arg Pro Phe Ala Val Ile Ser Gly Asp 1130 1135 1140 cgc aac cca att cac Arg Asn Pro Ile His 1145 oca ggt gtg atc gtg Pro Gly Val Ile Val 1160 tot gat gtt gcg got tco Ser Asp Val Ala Ala Ser 1150 otg got ggt ctg Leu Ala Gly Leu 1155 3571 3619 cac ggc atg tgg aco His Gly Met Trp Thr 1165 tot goo ato ggt gaa otg Ser Ala Ile Gly Glu Leu 1170 ato goo ggt Ile Ala Gly 1175 goa goa tto Ala Ala Phe aao gat Asn Asp 1180 gag oag atc Giu Gin Ile oaa aot Gin Thr 1185 000 goa goo Pro Ala Ala 3667 aag gtc gtg gaa tac Lys Val Val Glu Tyr 1190 aoo gca aoc atg Ctg Thr Ala Thr Met Leu 1195 ago gtt gag cgc too Ser Val Glu Arg Ser gca oca Ala Pro 1200 gtt ott coa ggt Val Leu Pro Gly 3715 1205 3763 gaa gaa att gag Giu Glu Ile Giu tto Phe 1.210 goa Al a 15s gtg gao aao Val Asp Asn ogo ooa Arg Pro 1220 12: gga atg gga Gly Met Gly gag Giu 1225 gtCcegc ace gtt acc Val Arg Thr Val Thr gca Ala 30 ace gte aac Thr Val Asn ggc aao tta Gly Asn Leu 1235 12: gtg Ott aoo goo Val Leu Thr Ala 1240 acc got gtt Thr Ala Val gtg goa Val Ala 1245 got oca tot Ala Pro Ser act tto tao goa Thr Phe Tyr Ala 1250 3811 3859 3907 tto oca ggo oag ggo att Phe Pro Giy Gin Gly Ile 1255 oag too Gin Ser 1260 oag ggo atg Gin Gly Met ggt atg Gly Met 1265 gaa goa ogo Giu Ala Arg ogt aao tot oag gca Arg Asn Ser Gin Ala 1270 got Al a 127 ogo got ato tgg gao ogo goo gat goa oao Arg Ala Ile Trp Asp Arg Ala Asp Ala His 5 1280 3955 1285 acc ogo aat Thr Arg Asn eoa oge gaa Pro Arg Giu gtt ttq tao Val Leu Tyr 1320 aag otg ggo tto Lys Leu Gly Phe 1290 too ate gtg gaa ato gtg Ser Ile *Val Giu Ile Vai 1295 gaa aao aao Giu Asn Asn 1300 ooa gao ggo Pro Asp Gly 1315 4003 4051 gta acco Val Thr 1305 gtg gca ggg Val Ala Gly gag aag Glu Lys 1310 tto tto oao Phe Phe His oto aco oag ttc ace cag gtg ggc atg gca act otg ggo Leu Thr Gin Phe Thr Gin Val Gly Met Ala Thr Leu Gly 4099 1325 1330 gtt get cag ato get gaa atg ogt gaa goa eat qoo ttg aao oag egt 4147 Val Ala Gin Ile Ala Glu Met Arg Glu Ala His Ala Leu Asn Gin Arg 1335 3351340 1345 gca tac ttt Ala Tyr Phe 1350 gct gga cac icc gtt ggi gag tac aac gcg cit gci gca 4195 Ala Gly His Ser Val Gly Glu Tyr Asn Ala Leu Ala Ala 1355 1360 1365 tat qct ggt gig ctg icc ctg gaa tcc gti ctg gag atc gtt tac cgt Tyr Ala Gly Val Leu Ser Leu Glu Ser Val Leu Glu Ile Val Tyr Arg 1370 1375 1380 4243 cgi ggc ttg acc atg Arg Gly Leu Thr Met 1385 cac cgc ttg gig gat His Arg Leu Val Asp 1390 cgc gat gaa aac ggt ctg Arg Asp Giu Asn Gly Leu 1395 4291 tcc aac tac gcq Ser Asn Tyr Ala 1400 cic gca gci Leu Ala Ala cit cgc Leu Arg 1405 ccc aac aag Pro Asn Lys aig ggi cig acc Met Gly Leu Thr 1410 gca gac aac Ala Asp Asn 1415 git tic gat Val Phe Asp tac gt Tyr Val 1420 gcg tot gt Ala Ser Val icc gaa Ser Glu 1425 gci tcc ggt Ala Ser Gly 4339 4387 4435 1445 gaa itc cig gag aic Glu Phe Leu Glu Ile 1430 git aac tac Val Asn Tyr 1435 aac tig gci ggc Asn Leu Ala Gly 1440 ciq cag tao gca Leu Gin Tyr Ala git got gga acc Val Ala Gly Thr cag gci Gin Ala 1450 ggi cii gcc Gly Leu Ala gcc cii Ala Leu 1455 cgi gcc gai Arg Ala Asp git gag Val Glu 1460 4483 aac ogi gca Asn Arg Ala cca ggi cag cgi gcc Pro Giy Gin Arg Ala 1465 tic ati Phe Ile 1470 tig aic cct Leu Ile Pro ggc ait gac Gly Ile Asp 1475 4531 4579 gig cca tic cac Val Pro Ph-e His 1480 icc icc aag Ser Ser Lys cig cgc Leu Arg 1485 gac ggi gig Asp Gly Val ggc gcg tic cgi Gly Ala Phe Arg 1490 gag cac Giu His 1495 git ggc Val Gly 1510 cii gat icc cig Leu Asp Ser Leu aic cca Ile Pro 1500 gct gag cig Ala Giu Leu gai cig Asp Leu 1505 gat gig cig Asp Val Leu 4627 cgc tac at Arg Tyr Ile cca aac Pro Asn 1515 tig gig gci Leu Val Ala cgc cca Arg Pro 1520 tic gaa cic act 4 Phe Glu Leu Thr 1525 675 gaa gag tic gig gca icc aig gca gaa Giu Glu Phe Val Ala Ser Met Ala Giu 1530 gig gig Val Val 1535 gag icc acc tat gic Giu Ser Thr Tyr Val 1540 4723 4771 aai gag aic itg gct gat tic aag gct gci icc gcc gat aag cag aag Asn Glu Ile Leu Ala Asp Phe Lys Ala Ala Ser Ala Asp Lys Gin Lys 1545 1550 1555 cii goc ogo acg tig cii ati gag cig cii gca igg Leu Ala Arg Thr Leu Leu Ile Glu Leu Leu Ala Trp 1560 1565 cci gig cgc igg aic gag act cag gat cig tig aic Pro Val Arg Trp Ile Giu Thr Gin Asp Leu Leu Ile cag tic gca ica Gin Phe Ala Ser 1570 4819 aag ggc cit caa 4867 Lys Gly Leu Gin 585 1575 1580 1 gct gag Ala Glu 1590 cgt ttc gtg gag gtc Arg Phe Val Glu Val 1595 ggt gtt ggc tct get Gly Val Gly Ser Ala 1600 cgc ctt cct cag tac Arg Leu Pro Gin Tyr 1615 cca acg ctt gcc 4 Pro Thr Leu Ala 1605 gcg gac gcc acc 4 Ala Asp Ala Thr 1620 915 aac atg atg ggc cag acc Asn Met Met Gly Gin Thr 1610 963 att gag gtg tta aac Ile Glu Val Leu Asn 1625 att gag cgc gat cgc Ile Glu Arg Asp Arg 1630 cca gtt gtg ttc got acc Pro Val Val Phe Ala Thr 1635 5011 gat gag gtt gtg Asp Glu Val Val 1640 cgt gaa gtg Arg Glu Val gcg gtt Ala Val 1645 gaa gag acc Glu Glu Thr cca gca get cct Pro Ala Ala Pro 1650 5059 5107 gca gaa ace Ala Glu Thr 1655 act gaa acc Thr Glu Thr cca gca Pro Ala 1660 acc cca gca Thr Pro Ala acc cca Thr Pro 1665 gcc cct gtt Ala Pro Val gca get Ala Ala 1670 gca gcc cct Ala Ala Pro gcc acc Ala Thr 1675 ggc ggc cct Gly Gly Pro cgc cca Arg Pro 1680 gat gac atc agc Asp Asp Ile Ser 5155 1685 5203 ttc act cct tct Phe Thr Pro Ser gat gcc Asp Ala 1690 act gaa atg Thr Glu Met ctc atc Leu Ile 1695 gct atc tgg Ala Ile Trp acc aag Thr Lys 1700 gtt cgc cca Val Arg Pro gat cag atg ggt gcc Asp Gin Met Gly Ala 1705 act Thr 171 gat tcc ate Asp Ser Ile 0 gag acc ctg gtt Glu Thr Leu Val 1715 gat ctt ggt gtg Asp Leu Gly Val 1730 gag ggc gtg tcc Glu Gly Val Ser 1720 tct cgc cgt Ser Arg Arg aac cag Asn Gin 1725 ctc ctg ctg Leu Leu Leu 5251 5299 5347 gag ttc ggc ctc ggc gca Glu Phe Gly Leu Gly Ala 1735 att gac Ile Asp 1740 gga gca gcc gat got gag ctc ggt Gly Ala Ala Asp Ala Glu Leu Gly 1745 gat cta Asp Leu 1750 aag gtc acc Lys Val Thr gtg tec aag Val Ser Lys 1755 atg get aag ggc Met Ala Lys Gly 1760 tac aag gcg ttt 5395 Tyr Lys Ala Phe 1765 ggc cct gtg ctc Gly Pro Val Leu tec gat gct gca gct Ser Asp Ala Ala Ala 1770 gat gcc Asp Ala 1775 ctg cgt cgc Leu Arg Arg ctc act Leu Thr 1780 ggt cct acc Gly Pro Thr ggt aag cgc ccg gga Gly Lys Arg Pro Gly 1785 tac Tyr 179 ate gca gag cgc gtc acc ggc Ile Ala Glu Arg Val Thr Gly 5443 5491 5539 90 1795 acg tgg gaa ttg ggc cag Thr Trp Glu Leu Gly Gin 1800 gtg atc ggc gcc cgc gaa Val Ile Gly Ala Arg Glu 1815 tgg get gac Trp Ala Asp 1805 cac gtg gtc get gaa gtt His Val Val Ala Glu Val 1810 ggc gca tec ctg cgc ggc Gly Ala Ser Leu Arg Gly 1820 18 ggc gac ctg gcg 5587 Gly Asp Leu Ala tca ctg tot. cot gca agc cca gog tct gca tca gat ctt gat tc 'g ctt 5635 Ser Leu Ser Pro Ala Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu 1830 1835 1840 1845 ato gac gca gcc gtc cag goc gta goc tcc cgc cgc ggc gtt gcg gtc 5683 Ile Asp Ala Ala Val Gin Ala Val Ala Ser Arg Arg Gly Val Ala Val 1850 1855 1860 ~ttcc otg oct tca gca C] Ser Leu Pro Ser Ala 1865 ggc ggo gct gco ggt Gly Gly Ala Ala Gly 1870 ggc gtg gtt gat tcc gca Gly Val Val Asp Ser Ala 1875 5731 got ott ggc gag Ala Leu Gly Giu 1880 got cag gca goo Ala Gin Ala Ala 1895 ttt goa gag Phe Ala Glu cag gtc Gin Val 1885 aoo gga oao Thr Gly His gat ggt gtg ott Asp Gly Val Leu 1890 5779 ogo aco ato ttg aco Arg Thr Ile Leu Thr 1900 cag ttg ggt ott gat aag oca Gin Leu Gly Leu Asp Lys Pro 1905 goa aoo Ala Thr 1910 gtt too gtg Val Ser Val gaa gao Glu Asp 1915 aco goa gag Thr Ala Glu gaa gao Glu Asp 1920 oto tao gag ttg Leu Tyr Giu Leu 5827 5875 1925 5923 gto too aag gaa Val Ser Lys Giu oto ggt tot gat tgg Leu Gly Ser Asp Trp 1930 oca ogt Pro Arg 1935 cag gtt goa Gin Val Ala oca ago Pro Ser 1940 tto gat gaa Phe Asp Glu gaa aag gtt Glu Lys Val 1945 gtt otg ott gat Val Leu Leu Asp 1950 gao ogt tgg Asp Arg Trp got tot gcg Ala Ser Ala 1955 ogt gag gat oto Arg Giu Asp Leu 1960 too gcg ttg Ser Ala Leu oto ttg Leu Leu 1965 gog aao tog cag oaa otg ata Ala Asn Ser Gin Gln Leu Ile 1970 ttg oag cac aag otg aat tot Leu Gin His Lys Leu Asn Ser 1985 5971 6019 6067 tog atg toa cag gog cag Ser Met Ser Gin Ala Gin 1975 gcg aag otg Ala Lys Leu 1980 t tg Leu 199C gao ttg atg ato tog oag ota ggc tog Asp Leu Met Ile Ser Gin Leu Gly Ser oga aca Arg Thr 2000 aag ott ott gga 6115 Lys Leu Leu Gly 2005 1995 ota ogo oga caa Leu Arg Arg Gin tgt tgo gqo Cys Cys Gly 2010 6136 <210> <211> 2012 <212> PRT <213> Corynebacterium glutamioum <400> Leu Lys Thr Leu Arg Ala Ala Val Ala Ala Gly Ala Gly Thr Asn Val Ser Asp Ile Val Glu Arg Ala Asn Ala Leu Leu Ala Leu Val Ala Asp \O aD \O 0 0 c <D i^ Asp Asn Val Ala Gin Glu Ala Ser 145 Ala Asn Arg Ile Pro 225 Val Leu Val Asp Glu 305 Ala Gin Val Leu Asn Pro Gin Gly Leu Arg 130 Ile Cys Ser Val Glu 210 Leu Glu Thr Ala Val 290 Gly Lys Glu Thr lle 35 Ser Gly Arg Val Val 115 Met Ala Ala Arg Val 195 Asp Lys Gin Arg Arg 275 Gly Arg Ile Phe Lys Gly Glu Ile Leu Leu 100 Ala Thr Gly Glu Asp 180 Lys Lys Val Thr Glu 260 Val Pro Gly Phe Ala 340 Phe Thr Asp Phe Asp 85 Gly Ile Gly Ile Val 165 Ser Val Leu Gin Val 245 Ile Asn Asp Ala Asp 325 Pro Thr Leu Pro Val 70 Val Val Ala Leu Ser 150 Pro Tyr Ile Arg Ala 230 Ala Ala Glu Gly Asp 310 Ala Arg Glu Pro Ala 55 Ser Asp His Gin Ile 135 Arg Ala Val Glu Gly 215 Ala Trp Ala Ala Gly 295 Ser Gly Val Leu Phe 40 Phe Gin Gin Leu Leu 120 Ala Glu Glu Leu Ala 200 Gly Phe Ala Asp Tyr 280 Ile Phe Met Glu Thr Gly Asp Ile Ala Leu 105 Ile Gin Gin Ile Val 185 Met Ser His Thr Val 265 Glu Val Tyr Ala His 345 Gly Phe Thr Ala Val 90 Asn Gly Gly Leu Arg 170 Gly Ala Ala His Thr 250 Leu Ala Lys Val Pro 330 Val Arg Asp Ala Thr 75 Ser Asp Ala Asp Gin 155 Pro Arg Ala Phe Pro 235 Ala Val Gly Leu Gly 315 Glu Asp Thr Pro Val Gin Ser Leu Asp Ser Ile Ala Thr Ala Ile 125 Asn Met 140 Gin Ala Val Ile Pro Asp Lys Asp 205 Ser Pro 220 Ala Met Gly Leu Asn Pro Ala Arg 285 Thr Ala 300 Asp Ala Leu Pro Gly Thr Pro Met Ala Ala Ser Gly Arg 110 Thr Pro Ile Gly Asp 190 Lys Arg Asn Asp Val 270 Trp Asn Ala Val Pro 350 Met Trp Val Leu His Ala Arg Met Asp Leu 175 Asn Lys Ile Met Val 255 Asp Phe Ile Gly Asp 335 Arg Leu Ala Ser Glu Ser Asp Thr Leu Ala 160 Arg Ala Ala Thr Ala 240 Glu Trp Leu Leu Gin 320 Tyr Leu Ala Gly Asn 385 Glu Gly Lys Gly Asp 465 Trp Ala Gly Leu Cys 545 Thr Gly Ser Trp Gin 625 Gly Arg Phe Met 370 Gly Leu Ile Met Ala 450 Glu Ile Ile Gly Ile 530 Val Gly Ile Gin Val 610 Leu Arg Arg Gly 355 Thr Gly Leu Asn Gin 435 Ser Ala Ala Ala Val 515 Ala Gly Ser Leu Ala 595 Pro Gly Leu Asp Asp 675 Pro His Glu Ala 420 Ile Ile Val Phe Lys 500 Ala Thr Gly Trp Val 580 Val Ala Ala Leu Glu 660 lie Thr Trp Thr 405 Gin Gly Asp Ala Lys 485 Glu Gly Tyr Gly Ser 565 Gly Lys Gly Asp Asp 645 Ile Gly Thr Ala 390 His Phe Gly Gly Leu 470 Pro Val Gly Gly Ile 550 Thr Thr Glu Gly Ile 630 Glu Ile Ser Val 375 Glu Ile Asn Lys Ile 455 Val Gly Pro His Lys 535 Gly Ser Ala Leu Ala 615 His Val Glu Met 360 Asp Leu Ala Ser Arg 440 Val Lys Ala Glu His 520 Val Ser Tyr Ala Leu 600 Lys Glu Ala Ala Thr 680 Pro Ala Gin Met 425 Leu Ile Glu Ile Leu 505 Ser Arg Pro Gly Met 585 Val Asn Ile Gly Ile 665 Tyr Ala Gly Leu 410 Phe Val Thr Leu Lys 490 Pro Trp Ala Glu Leu 570 Ala Ser Gly Asp Asp 650 Gly Glu lie Gly 395 Thr Leu Pro Ala Met 475 Gin Ile Glu Leu Arg 555 Pro Thr Thr Met Asn 635 Glu Lys Gin Val 380 Gly Asp Asp Lys Gly 460 Arg Val Ile Asp Asp 540 Ala Ala Lys Gin Ala 620 Ser Thr Thr Trp 365 Ala Gin Met Pro Ala 445 Ile Asp Asn Ile Leu 525 Asn Ala Met Glu Gly 605 Ser Phe Ala Ala Leu 685 Ala Val Leu Tyr 430 Arg Pro Gly Ser Gin 510 Asp Val Asp Pro Ala 590 Ser Gly Ala Val Lys 670 Asn Ala Thr Glu 415 Leu Ala Glu Phe Val 495 Ile Glu Val Tyr Val 575 Thr Asp Arg Lys Gin 655 Val Arg Ala Pro 400 Pro Trp Asn Lys Pro 480 Leu Glu Leu Leu Val 560 Asp Thr Glu Ser Ala 640 Ala Tyr Tyr Leu Ala 705 Glu Val Thr Lys Trp 785 Asp Lys Thr Gly Pro 865 Glu Asp Phe Ala Ala 945 Val Ile Glu 690 Ala Gin Asp Pro Pro 770 Arg Gin Ala Ile Lys 850 Ser Phe Ala Gly Leu 930 Met Asn Ala Leu Arg Asp Lys Ala 755 Val Ser Val Asn Glu 835 Val Val Glu Glu Thr 915 Pro Gly Asn Asp Ser Phe His Leu 740 Asp Asn Asp Ala Glu 820 Arg Leu Ile Ala His 900 Thr Ser Glu Gly Tyr 980 Pro Gin 710 Gin Ala Ala Val Leu 790 Ile Val Asp Ser Ser 870 His Met Glu Val Thr 950 Ala Asn Val 695 Met Phe Ala Trp Pro 775 Trp Pro Ala Glu Pro 855 Leu Ser Leu Leu Pro 935 Arg Thr Val Asp Leu Glu I Tyr I Phe I 760 Val Gin Gly Asp His 1 840 Gly Gly I Pro Thr Lys 920 Leu Ile j Trp Thr i Asp 1000 Gin Arg Ser 730 His Gly Asp His Val 810 Leu Ser Phe Ala Gly 890 Pro Arg Thr Ala Thr 970 Gly Trp Ala 715 Leu Ala Leu Lys Asp 795 Ala Asp Arg Trp Asp 875 Ala Leu Phe Gin Gly 955 Ser Tyr Ile 700 Glu Thr Ala Cys Asp 780 Asp Val Arg Ser Ala 860 Lys Asn Ala Thr Glu 940 Gly Val Leu Asp Ala Val Thr Arg 765 Val Arg Ala Phe Arg 845 Gly Trp Leu Gly Ser 925 Asp Thr Asp Pro Ser Leu Asp 735 Leu Pro Arg Thr Ile 815 Asp Ile Asn Arg Tyr 895 Thr Ile Glu Ala Gly 975 Ser Trp Ile 720 Gly Leu Gly Trp Ala 800 Thr Ala Met Ile Ser 880 Glu Ala Asp Ala Thr 960 Val Val Val Pro Ala His Thr Ala Pro 995 Val Leu Val Gly Arg Ala Trp Pro 1005 Ala Val Phe Ala Ala Val Lys Ser Ala Val Ile Pro Gly Thr Asp Ser 1010 1015 1020 Ala Ser Val Val Glu Gly Met Leu Ser Leu Val His Leu Glu His His 1025 1030 1035 1040 Ile Val Leu Lys Ser Asp Val Pro Thr Asp Gly Ala Leu Lys Val Ser 1045 1050 1055 Ala Thr Ala Asp Glu Val Val Asp Thr Asp Leu Gly Arg Leu Val Ile 1060 1065 1070 Val Arg Ala Glu Ile Ala Asp Ala Glu Gly Asn Leu Ile Ala Thr Leu 1075 1080 1085 Ala Glu Arg Phe Ala Ile Arg Gly Arg Lys Gly Asn Ala Val Ala Arg 1090 1095 1100 Thr Asn Thr Ser Ala Leu Pro Thr Thr Val Asp Thr Pro Arg Ser Ala 1105 1110 1115 1120 Arg Ala Val Ala Thr Val Val Ala Pro Glu Ser Met Arg Pro Phe Ala 1125 1130 1135 Val lie Ser Gly Asp Arg Asn Pro Ile His Val Ser Asp Val Ala Ala 1140 1145 1150 Ser Leu Ala Gly Leu Pro Gly Val Ile Val His Gly Met Trp Thr Ser 1155 1160 1165 Ala Ile Gly Glu Leu Ile Ala Gly Ala Ala Phe Asn Asp Glu Gin Ile 1170 1175 1180 Gin Thr Pro Ala Ala Lys Val Val Glu Tyr Thr Ala Thr Met Leu Ala 1185 1190 1195 1200 Pro Val Leu Pro Gly Glu Glu Ile Glu Phe Ser Val Glu Arg Ser Ala 1205 1210 1215 Val Asp Asn Arg Pro Gly Met Gly Glu Val Arg Thr Val Thr Ala Thr 1220 1225 1230 Val Asn Gly Asn Leu Val Leu Thr Ala Thr Ala Val Val Ala Ala Pro 1235 1240 1245 Ser Thr Phe Tyr Ala Phe Pro Gly Gin Gly Ile Gin Ser Gin Gly Met 1250 1255 1260 Gly Met Glu Ala Arg Arg Asn Ser Gin Ala Ala Arg Ala Ile Trp Asp 1265 1270 1275 1280 Arg Ala Asp Ala His Thr Arg Asn Lys Leu Gly Phe Ser Ile Val Glu 1285 1290 1295 Ile Val Glu Asn Asn Pro Arg Glu Val Thr Val Ala Gly Glu Lys Phe 1300 1305 1310 Phe His Pro Asp Gly Val Leu Tyr Leu Thr Gin Phe Thr Gin Val Gly 1315 1320 1325 Met Ala Thr Leu Gly Val Ala Gin Ile Ala Glu Met Arg Glu Ala His 1330 1335 1340 Ala Leu Asn Gin Arg Ala Tyr Phe Ala Gly His Ser Val Gly Glu Tyr 1345 1350 1355 1360 Asn Ala Leu Ala Ala Tyr Ala Gly Val Leu Ser Leu Glu Ser Val Leu 1365 1370 1375 Glu Ile Val Tyr Arg Arg Gly Leu Thr Met His Arg Leu Val Asp Arg 1380 1385 1390 Asp Glu Asn Gly Leu Ser Asn Tyr Ala Leu Ala Ala Leu Arg Pro Asn 1395 1400 1405 Lys Met Gly Leu Thr Ala Asp Asn Val Phe Asp Tyr Val Ala Ser Val 1410 1415 1420 Ser Glu Ala Ser Gly Glu Phe Leu Glu Ile Val Asn Tyr Asn Leu Ala 1425 1430 1435 1440 Gly Leu Gin Tyr Ala Val Ala Gly Thr Gin Ala Gly Leu Ala Ala Leu. 1445 1450 1455 Arg Ala Asp Val Glu Asn Arg Ala Pro Gly Gin Arg Ala Phe Ile Leu 1460 1465 1470 Ile Pro Gly Ile Asp Val Pro Phe His Ser Ser Lys Leu Arg Asp Gly 1475 1480 1485 Val Gly Ala Phe Arg Glu His Leu Asp Ser Leu Ile Pro Ala Glu Leu 1490 1495 1500 Asp Leu Asp Val Leu Val Gly Arg Tyr Ile Pro Asn Leu Val Ala Arg 1505 1510 1515 1520 Pro Phe Glu Leu Thr Glu Glu Phe Val Ala Ser Met Ala Glu Val Val 1525 1530 1535 Glu Ser Thr Tyr Val Asn Glu Ile Leu Ala Asp Phe Lys Ala Ala Ser 1540 1545 1550 Ala Asp Lys Gin Lys Leu Ala Arg Thr Leu Leu Ile Glu Leu Leu Ala 1555 1560 1565 Trp Gin Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gin Asp Leu Leu 1570 1575 1580 Ile Lys Gly Leu Gin Ala Glu Arg Phe Val Glu Val Gly Val Gly Ser 1585 1590 1595 1600 Ala Pro Thr Leu Ala Asn Met'Met Gly Gin Thr Leu Arg Leu Pro Gln 1605 1610 1615 Tyr Ala Asp Ala Thr Ile Glu Val Leu Asn Ile Glu Arg Asp Arg Pro 1620 1625 1630 Val Val Phe Ala Thr Asp Glu Val Val Arg Glu Val Ala Val Glu Glu 1635 1640 1645 Thr Pro Ala Ala Pro Ala Glu Thr Thr Glu Thr Pro Ala Thr Pro Ala 1650 1655 1660 Thr Pro Ala Pro Val Ala Ala Ala Ala Pro Ala Thr Gly Gly Pro Arg 1665 1670 1675 1680 Pro Asp Asp Ile Ser Phe Thr Pro Ser Asp Ala Thr Glu Met Leu Ile 1685 1690 1695 Ala Ile Trp Thr Lys Val Arg Pro Asp Gin Met Gly Ala Thr Asp Ser 1700 1705 1710 Ile Glu Thr Leu Val Glu Gly Val Ser Ser Arg Arg Asn Gin Leu Leu 1715 1720 1725 Leu Asp Leu Gly Val Glu Phe Gly Leu Gly Ala Ile Asp Gly Ala Ala 1730 1735 1740 Asp Ala Glu Leu Gly Asp Leu Lys Val Thr Val Ser Lys Met Ala Lys 1745 1750 1755 1760 Gly Tyr Lys Ala Phe Gly Pro Val Leu Ser Asp Ala Ala Ala Asp Ala 1765 1770 1775 Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys Arg Pro Gly Tyr Ile Ala 1780 1785 1790 Glu Arg Val Thr Gly Thr Trp Glu Leu Gly Gin Gly Trp Ala Asp His 1795 1800 1805 Val Val Ala Glu Val Val Ile Gly Ala Arg Glu Gly Ala Ser Leu Arg 1810 1815 1820 Gly Gly Asp Leu Ala Ser Leu Ser Pro Ala Ser Pro Ala Ser Ala Ser 1825 1830 1835 1840 Asp Leu Asp Ser Leu Ile Asp Ala Ala Val Gin Ala Val Ala Ser Arg 1845 1850 1855 Arg Gly Val Ala Val Ser Leu Pro Ser Ala Gly Gly Ala Ala Gly Gly 1860 1865 1870 Val Val Asp Ser Ala Ala Leu Gly Glu Phe Ala Glu Gin Val Thr Gly 1875 1880 1885 His Asp Gly Val Leu Ala Gin Ala Ala Arg Thr Ile Leu Thr Gin Leu 1890 1895 1900 Gly Leu Asp Lys Pro Ala Thr Val Ser Val Glu Asp Thr Ala Glu Glu 1905 1910 1915 1920 Asp Leu Tyr Glu Leu Val Ser Lys Glu Leu Gly Ser Asp Trp Pro Arg 1925 1930 1935 Gin Val Ala Pro Ser Phe Asp Glu Glu Lys Val Val Leu Leu Asp Asp 1940 1945 1950 Arg Trp Ala Ser Ala Arg Glu Asp Leu Ser Ala Leu Leu Leu Ala Asn 1955 1960 1965 Ser Gin Gin Leu Ile Ser Met Ser Gin Ala Gin Ala Lys Leu Leu Gin 1970 1975 1980 His Lys Leu Asn Ser Leu Asp Leu Met Ile Ser Gin Leu Gly Ser Arq 1985 1990 1995 2000 Thr Lys Leu Leu Gly Leu Arg Arq Gin Cys Cys Gly 2005 2010 <210> 51 <211> 2185 <212> DNA <213>' Corynebacterium qiutamicun <220> (221> CDS <222> (101)..(2185) <223> FRXA00158 <400> 51 cgtgccattt. tctttacaaa agagtattaa ccgaaacttc aqgtcaggat ccacgccctg cqttcatccc ggctaagtta tacaaggagc gagttctcac gtg aCC gaa ttg agc Val Thr Glu Leu Ser agg Arg ttt Phe cgt Arg gag Giu acc Thr gat Asp ttt Phe gat Asp ggC Gly att aac ttc Asn Phe gCC ttc Ala Phe gcc gcg Ala Aia cgc gca Arg Aia ctt cca Leu Pro cca gct Pro Ala gtC tcc Val Ser gtg gat Val Asp 120 gtg cac Vai His 135 gcq cag 9qg Gi y gct Al a gtt Val1 aat Asn ttt Phe ttC Phe ca g Gin 105 cag Gin ctq Leu ttg 9CC Al a ttc Phe gcc Ala gcg Al a ggt Gly gat Asp atc Ile gct Ala ctc Leu atc agc: cga Ser Arg 9CC qqc Ala Gly gca qgt Ala Gly Ctg ctt Leu Leu 60 ttc gat Phe Asp 75 act gca Thr Ala gca acc Ala Thr gtg tC Val Ser aat gat Asn Asp 140 ggt gca ctg att Leu Ile caa 998 Gin Gly 30 gca gqc Ala Gly 45 gca cta Ala Leu CCa qtg Pro Val caa tct Gin Ser Ctg gat Leu Asp 110 agc att Ser Ile 125 gcg act Ala Thr gcg atc aac Asn tat Tyr 8CC Thr gt t Val1 gct Ala Al a t cc Ser ggt Gly Cgt Arg acc CC Arg gac Asp aat As n gCa Ala tgg Trp gtg Val1 ct t Leu cat His gct Ala CgC 1 ttt Phe tgq Trp gtt Val1 ga t Asp gct. Al a agc Ser gag Glu tcC Ser ga t Asp 145 acc ggc Gly ttq Leu agt Ser ga t Asp aac Asn gtg Val1 9gg Ala cag Gin 130 gaa Glu gca cag Gin aag Lys 98 C Asp ctc Le u aac As n CCg Pro cag Gin 115 ggc Gi y ctc Le u cgC 163 211 259 307 355 403 451 499 547 595 Ala Gin Leu Ile Gly 155 Ala Ala Ile Thr Arg 160 Thr Ala Arg Met ggc ctg atc gcg Gly Leu Ilie Ala ggc gao aac atg Gly Asp Asn Met atg ctg tog atc Met Leu Ser Ile 9CC gga Ala Gly 180 643 att toc ogo Ile Ser Arg qtc cct gcg Val Pro Ala 200 gaa Giu 185 cag ctt oag caa Gin Leu Gin Gin atc gao gcg gcc Ile Asp Ala Ala tgo gcc gaa Cys Ala Giu 195 tca cgc gat Ser Arg Asp gag atc 090 009 Glu Ile Arg Pro atc ggt ctq cgc Ile Gly Leu Arg tot tat Ser Tyr 215 gtt ttg gtt ggc Val Leu Val Giy oca gac gao aac Pro Asp Asp Asn qct Ala 225 cgc gtt gtt aag Arg Val Val Lys gtc Val1 230 att gag gca atg Ile Glu Ala Met got Al a 235 900 aag gat aag Ala Lys Asp Lys gco att gaa gat Ala Ile Glu Asp otg ogc go ggt Leu Arg Gly Gly gog tto ago co Ala Phe Ser Pro att act oog ctg Ile Thr Pro Leu sag gtg Lys Val 260 oag got got Gin Ala Ala gtg gog tgg Val Ala Trp 280 ttc Phe 265 oat cso ooa gct His His Pro Ala atg Met 270 aac stg got gtg Asn Met Ala Val gag oag aoo Glu Gin Thr 275 soc ogo gag Thr Arg Glu 931 979 gos aoo sot got Ala Thr Thr Ala ggt Gly 285 ttg gat gtg gas Leu Asp Val Giu atc 900 Ile Ala 295 got gat gtt ttg Ala Asp Val Leu asc cot gtc gat Asn Pro Val Asp tg T rp 305 gts gca ogo gtc Val Ala Arg Val sac Asn 310 gsa gog tat gag Giu Ala Tyr Glu got Al a 315 ggo got 090 tgg Gly Ala Arg Trp oto gao gtt gga Leu Asp Val Gly gat ggt ggo ato Asp Gly Gly Ile gtt sag ctg act gcc sac ato ott gag ggo ogo 990 Val Lys Leu Thr Ala Asn Ile Leu Glu Gly Arg Gly 330 335 340 1027 1075 1123 1171 1219 909 gat too Ala Asp Ser gat got ggc Asp Ala Gly 360 tto Phe 345 tat gtt ggt gao Tyr Val Gly Asp 900 Ala 350 905 990 cag 900 Ala Gly Gin Ala sag ata ttt Lys Ile Phe 355 gag tto gca Giu Phe Ala atg gca cot ga Met Ala Pro Glu ott Leu 365 Cca gtg gat tao Pro Val Asp Tyr oca 090 Pro Arg 375 gtt gag oso gtt Val Giu His Val gga aco cos 090 Gly Thr Pro Arg otg Leu 385 gtt aoo sag tto Val Thr Lys Phe 1267 act gag otg soc 990 090 soc oca atg atg ctg got ggc atg aoo oca Thr Glu Leu Thr Gly Arg Thr Pro Met Met Leu Ala Gly met Thr Pro 1315 acc acc gtt qac: Thr Thr Val Asp qcc att gtt gca Ala Ile Val Ala gcc Ala 415 gct gca aac gqt Ala Ala Asn Gly gga cac Gly His 420 1363 tgg gct gag Trp Ala Glu acc cac atc Thr His Ile 440 cag ttc aac Gin Phe Asn 455 ctc Leu 425 gct ggt ggc gga Ala Gly Gly Gly gtt aco cca gag Val Thr Pro Gin ctg ctg gaa Leu Leu Glu 435 atc aac gcc Ile Asn Ala gca cag ctc acc Ala Gin Leu Thr ga c Asp 445 atg ctt gag cca Met Leu Giu Pro 1411 1459 1507 tcc atg ttc Ser Met Phe gat oca tac ctg Asp Pro Tyr Len aaq atg cag att Lys Met Gin Ile ggt Gly 470 ggc: aag cgc ctt Gly Lys Arg Leu cct aag gcc cgc Pro Lys Ala Arg gct aat ggt gca Ala Asn Gly Ala 480 gaa aag gat gaa Gin Lys Asp Gin t cc Ser atc: Ile 485 1555 1603 gac gqc atc gtc Asp Gly Ile Val at c Ile 490 acc gcc ggc att Thr Ala Gly Ile cct Pro 495 gct gtt Ala Val 500 qca ttg gtc Ala Len Val aag cca ggt Lys Pro Gly 520 gaa ctg atg cgt Giu Len Met Arg ggt ttc cct tgg Gly Phe Pro Trp atc gca ttc Ile Ala Phe 515 atc gct aag Ile Ala Lys gcc atc aag cag Ala Ile Lys Gin qt t Val1 525 aac tct gtg ttg Asn Ser Val Leu gct Ala 530 gaa gtt Gin Val 535 cca gaa ctc ccc Pro Gin Len Pro atc att cag att Ile Ile Gin Ile ggt ggc gtt gca Gly Gly Val Ala 1651 1699 1747 1795 1843 ggt Gly 550 gga cac cac tct Giy His His Ser gaa gac ctc gat Glu Asp Len Asp ctg ctg atc gcc Leu Len Ile Ala acc Thr 565 tac ggc aag qtc Tyr Gly Lys Val cgc Arg 570 gca ctg gat aac Ala Leu Asp Asn gtg Val1 575 gtg ctg tgt gtc Val Leu Gys Val ggc ggt Gly Gly 580 qgc att ggc Gly Ile Gly tcc act tcc Ser Thr Ser 600 cct gag cgc gct Pro Gin Arg Ala gct Ala 590 gat tac gtc acc Asp Tyr Val Thr ggt tcc tgg Gly Ser Trp 595 atc ttg gtg Ile Len Val 1891 1939 tac ggc ctg cca Tyr Gly Leu Pro gc t Al a 605 atg cct gtt gat Met Pro Val Asp ggc Gly 610 ggt acc: Gly Thr 615 gct gcq atg gca Ala Ala Met Ala aag gaa gca acc Lys Giu Ala Thr acc Thr 625 tcc cag gcc gtc Ser Gin Ala Val 1987 2035 gaa ctt ctt gtt Giu Leu Leu Val acc cag ggc tct Thr Gin Gly Ser gaa tgg gtt cct Gin Trp Val Pro gct Al a 645 ggt ggc gca aag aac gga atg gca tat ggc cgt tcc cag ctt ggc gca 2083 Gly Gly Ala Lys Asn Gly Met Ala Tyr Gly Arg Ser Gin Leu Gly Ala 650 655 660 gac ate cac gag atc gac aac tcc ttt gct aag gct gga cgc ctt ctt 2131 Asp Ile His Glu Ile Asp Asn Ser Phe Ala Lys Ala Gly Arg Leu Leu 665 670 675 gat gag gtt gca ggc cat gaa acg gat ttg caa gcg cgc ccg gat gag 2179 Asp Glu Val Ala Gly His Glu Thr Asp Leu Gin Ala Arg Pro Asp Glu 680 685 690 ate att 2185 Ile Ile 695 <210> 52 <211> 695 <212> PRT <213> Corynebacterium glutamicum <400> 52 Val Thr Glu Leu Ser Arg Asn Phe Gly Ala Ser Arg Leu Ile Asn Arg 1 5 10 Phe Gly Gin Glu Pro Phe Ala Phe Ala Phe Ala Gly Gin Gly Tyr Asp 25 Trp Leu Lys Thr Leu Arg Ala Ala Val Ala Ala Gly Ala Gly Thr Asn 40 Val Ser Asp Ile Val Glu Arg Ala Asn Ala Leu Leu Ala Leu Val Ala 55 Asp Asp Leu Ile Gly Thr Leu Pro Phe Gly Phe Asp Pro Val Ala Trp 70 75 Ala Asn Asn Ser Glu Asp Pro Ala Phe Asp Thr Ala Gin Ser Ala Val 90 Ser Val Pro Gly Ile Phe Val Ser Gin Ile Ala Thr Leu Asp Ser Leu 100 105 110 Glu Ala Gin Arg Leu Asp Val Asp Gin Ala Val Ser Ser Ile Gly His 115 120 125 Ser Gin Gly Val Leu Gly Val His Leu Leu Asn Asp Ala Thr Arg Ala 130 135 140 Asp Glu Leu Val Ala Ile Ala Gin Leu Ile Gly Ala Ala Ile Thr Arg 145 150 155 160 Thr Ala Arg Met Thr Gly Leu Ile Ala Gin Gly Asp Asn Met Pro Met 165 170 175 Leu Ser Ile Ala Gly Ile Ser Arg Glu Gin Leu Gin Gin Ala Ile Asp 180 185 190 Ala Ala Cys Ala Glu Val Pro Ala Glu Ile Arg Pro Val Ile Gly Leu Arg Al a 225 Ala Thr Al a Giu Trp 305 Le u Leu Gin T yr Leu 385 Ala Ala Pro Pro Trp 465 As n Lys Pro As n 210 Arg Ile Pro Val1 Leu 290 Val1 As p Glu Al a Gin 370 Val1 Gly As n Giu Gly 450 Lys Gi y Asp Trp 195 Ser Val1 Giu Leu Giu 275 Thr Ala Val1 Gly Lys 355 Glu Thr Met Gly Leu 435 Ile Met Ala Giu Ile 515 Arq Asp Ser Tyr Val Asp Lys 260 Gin Arg Arg Gly Ar g 340 Ile Ph e Lys Thr Gly 420 Leu Asn Gin Ser Ala 500 Al a Lys Lys 245 Val1 Th r Glu Val1 Pro 325 Gly Phe Al a Phe Pro 405 His Giu Aila Ile Ile 485 Val1 Phe Val1 230 Leu Gin Val Ile Asn 310 Asp Ala Asp Pro Thr 390 Thr T rp T hr Gin Gly 470 Asp Al a Lys 200 Val1 Glu Gly Ala T rp 280 Al a Ala Gly Ser Gly 360 Val1 Leu Val1 Glu Ile 440 As n Ly s Ile ValI Gly 520 Ala Gly Ph e 265 Ala Asp Tyr Ile Phe 345 Met Giu Thr Asp Le u 425 Ala Ser Arg Val1 Lys 505 Ala Leu Val Gly Arg Met Ser 250 His Thr Val1 Glu ValI 3230 Tyr Ala His Gly Pro 410 Al a Gin Met Leu Ile 490 Giu Ile 220 Ala Phe Pro Ala Val1 300 Gly Leu Gly Giu Asp 380 Thr Ile Gly Thr Leu 460 Pro Al a Met Gin 205 Pro Lys Ser Ala Gi y 285 As n Al a Thr Asp Leu 365 Gi y Pro Val1 Gly Asp 445 Asp Lys Gly Arg Val 525 Asp Pro Met 270 Le u Pro Arg Ala Ala 350 Pro Th r Met Al a Gin 430 Met Pro Ala Ile Asp 510 As n Asp Asp Asn Lys 240 Ile Met Vali Asp Phe 320 Ile Gi y Asp Arg Le u 400 Al a Thr Glu Leu Al a 480 Giu Phe ValI Leu Ala Ile Ala Lys Giu Vai Pro Glu Leu Pro Ile Ile Ile Gin Ile 530 535 540 Glu 545 Leu Leu Val1 Asp Thr 625 Giu Ser Al a Ala Giy Leu Cys Thr Gly 610 Ser Trp Gin Gly Arg 690 Gly Ile Val1 Gly 595 I le Gin Val Leu Arq 675 Pro Val Ala Gly 580 Se r Leu Al a Pro Gi y 660 Leu Asp Al a Thr 565 Gly Trp Val1 Val1 Ala 645 Ala Leu Glu Gi y 550 Tyr Gi y Ser Gly Lys 630 Gi y Asp Asp Ile His Lys Gly Ser 600 Ala Leu Al a His Val1 680 His Val Ser 585 Tyr Ala Leu Lys Glu 665 Ala Ser Arg 570 Pro Gi y Met Val1 Asn 650 Ile Gly Trp 555 Ala Glu Leu Ala Ser 635 Gly Asp His Glu Le u Arg Pro Thr 620 Thr Met Asn Glu Le u As n Al a 590 Met Glu Gi y Tyr Phe 670 Asp Asp Val1 575 Asp Pro Ala Ser Gly 655 Ala Leu <210> 53 <211> 3831 <212> DNA <213> Corynebacterium glutamicum (220> <221> CDS <222> (1)..(3831) <223> FRXA00572 <400> 53 cag tgg etc aac cgc tao etc gag otg Gin Trp Leu Asn Arg Tyr Leu Glu Leu 1 tgg att gat gct tcc tgg got gca cgt Trp Ile Asp Ala Ser Trp Ala Ala Arg 25 gcc gag gcg egt ttq atc gag cag gat Ala Glu Ala Arg Leu Ile Glu Gin Asp ctg aeg gtg gag gat ggc gte gac aag Leu Thr Val Glu Asp Gly Val Asp Lys ggc Gly gee Ala gge Gly gtt Val1 ga t Asp etg Leu gag Glu tao Tyr gca aco gac otg Ala Thr Asp Leu aco ccg gct gat Thr Pro Ala Asp gt o Val1 gcc tgg ttc ttg Ala Trp Phe Leu ggc Gl y 240 288 otg tgc cgc aog Leu Cys Arg Thr ggc aag Oct gtg Gly Lys Pro Val ttt gtg ccc gtc The Val Pro Val att gat Ile Asp aag gac gtg Lys Asp Val gat gat cgc Asp Asp Arg 115 cgc tgg tgg cgc Arg Trp Trp Arg gac toc ctg tgg Asp Ser Leu Trp cag tcc cac Gin Ser His 110 ggt gtc gtc Gly Val Val 336 384 tac acc got gat Tyr Thr Ala Asp cag Gin 120 gtg got att atc Val Ala Ile Ile gcc gtt Ala Val 130 got ggc atc acc Ala Gly Ile Thr gcc aac gaa cot Ala Asn Glu Pro gtc gct gac ctg ctt Val Ala Asp Leu Leu 140 gat gag oac gat tcc Asp Glu His Asp Ser gat Asp 145 cgc ttt gto gac Arg Phe Val Asp gco Ala 150 aoc ato gag cgc Thr Ile Glu Arg cgc too cgo gao Arg Ser Arg Asp atg ggo aaa gtg Met Gly Lys Val too toa oct ggo Ser Ser Pro Gly aoa tto Thr Phe 175 tgg got ggo ogo aao ato ooa tog gtg Trp Ala Gly Arg Asn Ile Pro Ser Val 180 185 ato oao ago ott Ile His Ser Leu ggg oat got Gly His Ala 190 ooa. aoc ggo Pro Thr Gly gao aag tgg Asp Lys Trp 195 too ogo too gaa Ser Arg Ser Glu tto Phe 200 gaa goa tto oat Giu Ala Phe His ago Se r 205 goo aao Ala Asn 210 ttg gtg tao gaa. Leu Val Tyr Glu gao Asp 215 goo gag cao gog Ala Giu His Ala otq act gtq Oct Leu Thr Val Pro ttg Leu 225 gcg ggt too aco Ala Gly Ser Thr tto ggo aoo acc Phe Gly Thr Thr gag otg aaa ato Giu Leu Lys Ile tto aoo ago ooo Phe Thr Ser Pro ato Ile 245 gao got otg ooa Asp Ala Leu Pro got gto oca otg Ala Val Pro Leu gto aoo Val Thr 255 oag gaa gao Gin Glu Asp ggo ggo aoo Gly Gly Thr 275 gaa. goc gog atg Glu Ala Ala Met ggt Gly 265 gaa otg aoo ogo Glu Leu Thr Arg ato goa got Ile Ala Ala 270 tgg gaa aco Trp Glu Thr 816 864 ctg goa act gtg Leu Ala Thr Val aat ggc aco got Asn Gly Thr Ala aco Thr 285 too gto Ser Val 290 gat goo ggo gtc Asp Ala Gly Val ato Ile 295 got gao tao aao Ala Asp Tyr Asn gto aoo goa ggc Val Thr Ala Gly tac Tyr 305 ctg cca gca tee Leu Pro Ala Ser gtt Cct gca eac Val Pro Ala His gca cct gac gtg Ala Pro Asp Val 960 1008 gtt ggc cgc gca Val Gly Arg Ala t gg Trp 325 cca gca gtt ttc Pro Ala Val Phe gee gta aag tcc Ala Val Lys Ser gca gte Ala Val 335 ate cca gge Ile Pro Gly gtt cac ctg Val His Leu 355 gat tcc gca tcc Asp Ser Ala Ser gtg gaa gge atg Val Glu Gly Met etg tee ctg Leu Ser Leu 350 eca ace qac Pro Thr Asp 1056 1104 gag eac cae att Giu His His Ile etc aaq tee gat Leu Lys Ser Asp ggc geg Gly Ala 370 etg aag gtt tee Leu Lys Val Ser geg Al a 375 act gee gat gag Thr Ala Asp Glu gta Val1 380 gte gat ace gac Val Asp Thr Asp ggt ege ctc gtg Gly Arq Leu Val gtg ege gea gaa Val Arg Ala Glu gee gac gca gaa Ala Asp Ala Glu 1152 1200 1248 aae etg att get Asn Leu Ile Ala a eg Thr 405 ttg gct gag cgt Leu Ala Glu Arg ttc Phd 410 geg ate ege gga Ala Ile Arg Gly ege aag Arg Lys 415 gge aac get Gly Asn Ala gac ace eea Asp Thr Pro 435 gca cgc ace aac Ala Arg Thr Asn tee gea etg eca Ser Ala Leu Pro ace ace gtg Thr Thr Val 430 gea cet gaa Ala Pro Glu 1296 1344 ege tea get ege Arg Ser Ala Arg gtg gea aec gtt Val Ala Thr Val tee atg Ser Met 450 ege eca tte get Arg Pro Phe Ala qtg Val1 455 ate tee ggt gac Ile Ser Gly Asp ege Arg 460 aae eca att eae Asn Pro Ile His tet gat gtt geg Ser Asp Val Ala tee etg get ggt Ser Leu Ala Gly eca ggt gtg ate Pro Gly Val Ile eac ggc atg tgg His Gly Met Trp ace Thr 485 tet gee ate ggt Ser Ala Ile Gly etg ate gee ggt Leu Ile Ala Gly gea gca Ala Ala 495 1392 1440 1488 1536 1584 ttc aae gat Phe Asn Asp aee gea ace Thr Ala Thr 515 cag ate eaa act GinIle Gin Thr ec Pro 505 gca gee aag gte Ala Ala Lys Val gtg gaa tac Val Glu Tyr 510 att gag tte Ile Giu Phe atg etg gea eea Met Leu Ala Pro ett eca ggt gaa Leu Pro Gly Giu age gtt Ser Val 530 gag ege tee gca Glu Arg Ser Ala gtg Val 535 gac aac ege eca Asp Asn Arg Pro atq gga gag gte Met Gly Giu Val 1632 cgc aec gtt ace gca aec gte aac gge aac tta gtg ett ace gee ace 68 1680 Thr Val Thr Ala Va AsGlAs Va LeTh lTr 550 Val Asn Gly Asn Val Leu Thr Ala gct qtt gtq gca Ala Val Val Ala gct Ala 565 cca tct act ttc Pro Ser Thr Phe tac Tyr 570 qca ttc cca ggc Ala Phe Pro Gly cag ggc Gln Gly 575 1728 att cag tcc Ile Gin Ser gct cgc gct Ala Arg Ala 595 ggc atg ggt atg Gly Met Gly Met gca cqc cqt aac Ala Arg Arg Asn tct cag gca Ser Gin Ala 590 aat aag ctg Asn Lys Leu 1776 1824 atc tgg gac cgc Ile Trp Asp Arg gat gca cac acc Asp Ala His Thr cgc Arg 605 ggc ttc Gly Phe 610 tcc atc gtg gaa Ser Ile Vai Glu a tc Ile 615 gtg gaa aac aac Val Glu Asn Asn cgc gaa gta acc Arg Glu Val Thr gca ggg gag aag Ala Gly Glu Lys ttc Phe 630 ttc cac cca gac Phe His Pro Asp gtt ttg tac ctc Val Leu Tyr Leu 1872 1920 1968 cag ttc acc cag Gin Phe Thr Gin gtg Vali 645 ggc atg qca act Gly Met Ala Thr ctg Leu 650 ggc gtt gct cag Gly Val Ala Gin atc gct Ile Ala 655 gaa, atg cgt Glu Met Arg cac tcc gtt His Ser Val 675 gca cat gcc ttg Ala His Ala Leu cag cgt gca tac Gln Arg Ala Tyr ttt gct gga Phe Ala Gly 670 ggt gtg ctg Gly Val Leu ggt gag tac aac Gly Glu Tyr Asn ctt gct gca tat Leu Ala Ala Tyr gct Ala 685 tcc ctg Ser Leu 690 gaa tcc gtt ctg Giu Ser Val Leu atc gtt tac cgt Ile Val Tyr Arg cgt Arg 700 ggc ttg acc atg Gly Leu Thr Met cgc ttg gtg gat Arg Leu Val Asp cgc Arq 710 gat gaa aac ggt Asp Glu Asn Gly tcc aac tac gcg Ser Asn Tyr Ala 2016 2064 2112 2160 2208 2256 2304 gca gct ctt cgc Ala Ala Leu Arg ccc Pro 725 aac aag atg ggt Asn Lys Met Gly acc gca gac aac Thr Ala Asp Asn gtt ttc Val Phe 735 gat tac gtt Asp Tyr Val gtt aac tac Val Asn Tyr 755 gcg Al a 740 tct gtt tcc gaa Ser Val Ser Glu gct Ala 745 tcc ggt gaa ttc Ser Gly Glu Phe ctg gag atc Leu Glu Ile 750 gga acc cag Gly Thr GIn aac ttg gct ggc Asn Leu Ala Gly ctg Leu 760 cag tac gca gtt Gin Tyr Ala Val gct ggt Ala Gly 770 ctt gcc gcc ctt Leu Ala Ala Leu gcc gat qtt gag Ala Asp Val Glu aac As n 780 cgt gca cca ggt Arg Ala Pro Gly 2352 cag cqt qcc ttc att ttg atc cct ggc att gac gtg cca ttc cac tcc Gin Arg Ala Phe Ile Leu Ile Pro Gly Ile Asp Val Pro Phe His Ser 2400 790 795 tcc aag ctg cgc Ser Lys Leu Arg ggt gtg ggc gcg Gly Val Gly Ala ttc Phe 810 cgt gag cac ctt Arg Glu His Leu gat tcc Asp Ser 815 2448 ctg atc cca Leu Ile Pro cca aac ttg Pro Asn Leu 835 gct Al a 820 gag ctg gat ctg Glu Leu Asp Leu ga t Asp 825 gtg ctq gtt ggc Val Leu Val Gly cgc tac att Arg Tyr Ile 830 ttc gtg gca Phe Val. Ala 2496 2544 gtg gct cgc cca Val Ala Arg Pro gaa ctc act gaa Glu Leu Thr Glu tcc atg Ser Met 850 gca gaa gtg gtg Ala Giu Val Val tcc acc tat gtc Ser Thr Tyr Val aa t As n 860 gag atc ttg gct Glu Ile Leu Ala ga t Asp 865 ttc aag gct gct Phe Lys Ala Ala tcc Ser 870 gcc gat aag cag Ala Asp Lys Gin ctt. gcc cgc acg Leu Ala Arg Thr 2592 2640 2688 ctt att gag ctg Leu Ile Glu Leu gca tgg cag ttc Ala Trp Gin Phe tca cct gtg cgc Ser Pro Val Arg tgg atc Trp Ile 895 gag act cag Giu Thr Gin gag gtc ggt Glu Val Gly 915 ga t Asp 900 ctg ttg atc Leu Leu Ile aag ggc Lys Gly 905 ctt caa gct gag Leu Gin Ala Glu cgt ttc gtg Arg Phe Val 910 atg ggc cag Met Gly Gin gtt ggc tct gct Val Gly Ser Ala cca Pro 920 acg ctt gcc aac Thr Leu Ala Asn acc ctg Thr Leu 930 cgc ctt cct cag Arg Leu Pro Gin gcg gac gcc acc Ala Asp Ala Thr att Ile 940 gag gtg tta aac Giu Val Leu Asn 2736 2784 2832 2880 2928 gag cgc gat cgc Giu Arg Asp Arg gtt gtg ttc gct Val Val Phe Ala acc Thr 955 gat gag gtt gtg Asp Giu Val Val gaa gtg gcg gtt Giu Val Ala Val gaa Giu 965 gag acc cca gca Giu Thr Pro Ala cct gca gaa acc Pro Ala Glu Thr act gaa Thr Giu 975 acc cca gca Thr Pro Ala gcc acc ggc Ala Thr Gly 995 cca gca acc cca Pro Ala Thr Pro ggc cct cgc cca Gly Pro Arg Pro gat gac Asp Asp 1000 cct gtt gca gct Pro Val Ala Ala atc agc ttc act Ile Ser Phe Thr 10 acc aag gtt cgc Thr Lys Val Arg 1020 gca gcc cct Ala Ala Pro 990 cct tct gat Pro Ser Asp cca gat cag Pro Asp Gin 2976 3024 3072 gcc act gaa atg ctc atc Ala Thr Glu Met Leu Ile 1010 gct atc tgg Ala Ile Trp 1015 atg ggt gcc act gat Met Gly Ala Thr Asp 1025 tcc atc gag acc ctg Ser Ile Glu Thr Leu 1030 gtt gag ggc gtg tcc tct 3120 Val Glu Gly Val Ser Ser 1035 1040 cgc cgt aac cag ctc ctg ctg gat ctt ggt gtg gag ttc ggc ctc ggc Arg Arq Asn Gin Leu Leu Leu Asp Leu Gly Val Glu Phe Gly Leu Gly 1045 1050 1055 3168 gca att gac gga gca Ala Ile Asp Gly Ala 1060 gtg tcc aag atg gct Val Ser Lys Met Ala 1075 gat gct gca gct gat Asp Ala Ala Ala Asp 1090 gcc gat gct gag ctc Ala Asp Ala Glu Leu 1065 aag ggc tac aag gcg Lys Gly Tyr Lys Ala 1080 gcc ctg cgt cgc ctc Ala Leu Arg Arg Leu 1095 ggt gat cta aag gtc acc Gly Asp Leu Lys Val Thr 1070 ttt ggc cct gtg ctc tcC Phe Gly Pro Val Leu Ser 1085 act ggt cct acc ggt aag Thr Gly Pro Thr Gly Lys 1100 3216 3264 3312 cgc ccg gga tac atc gca gag cgc gtc Arg Pro Gly Tyr Ile Ala Glu Arg Val 1105 1110 acc ggc acg tgg gaa. ttg ggc 3360 Thr Gly Thr Trp Glu Leu Gly 1115 1120 cag ggc tgq gct Gin Gly Trp Ala gac cac Asp His 1125 gtg qtC gCt Val Val Ala gaa gtt Glu Val 1130 gtg atc gqc Val Ile Gly gcc cgc Ala Arg 1135 3408 gaa ggc gca Giu Gly Ala tc ctg Ser Leu 1140 cgc ggC ggC Arg Gly Gly gac ctg gcg Asp Leu Ala 1145 tca ctg tct cct gca Ser Leu Ser Pro Ala 1150 3456 agc cca gcg tct gca tca gat ctt gat tcg ctt atc Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu Ile gac gca qcc gtc Asp Ala Ala Val 1165 1155 1160 3504 3552 cag gcc qta Gin Ala Val 1170 gcc tcc cgc cgc ggc Ala Ser Arg Arg Giy 1175 gtt gcg gtc Val Ala Val tcc ctg Ser Leu 1180 cct tca gca Pro Ser Ala ggc ggC Gly Gly 1185 gct qcc ggt ggc gtg gtt gat tcc gca gct ctt ggc gag ttt Ala Ala Gly Gly Val Val Asp Ser Ala Ala Leu Gly Glu Phe 1190 1195 3600 1200 3648 gca gag cag gtc acc gga. cac gat ggt gtg ctt gct cag gca gcc cgc Ala Glu Gin Val Thr Gly His Asp Gly Val Leu Ala Gin Ala Ala Arg 1205 1210 1215 acc atc ttg acc cag tig ggt ctt gat aag Thr Ilie Leu Thr Gin Leu Gly Leu Asp Lys 1220 1225 gaa gac acc gca gag gaa gac ctc tac gag Giu Asp Thr Ala Giu Giu Asp Leu Tyr Glu 1235 1240 ggt tct gat tgg cca cgt cag gtt gca cca Gly Ser Asp Trp Pro Arg Gin Val Ala Pro 1250 1255 gtt gtt ctg ctt gat gac cgt tgg gct tct Val Val Leu Leu Asp Asp Arg Trp Ala Ser 1265 1270 cca gca acc gtt tcc gtg Pro Ala Thr Val Ser Val 1230 ttg gtc tcc aag gaa ctc Leu Val Ser Lys Glu Leu 1245 agc ttc gat gaa gaa. aag Ser Phe Asp Glu Glu Lys 1260 gcg cgt gag Ala Arg Giu 1275 3696 3744 3792 3831 <210> 54 <211> 1277 <212> PRT <213> Corynebacterium glutamicum <400> 54 Gin Trp Leu Asn Arg Tyr Leu Glu Leu Ser Gly Pro Val Asp Gly Gin 1 5 10 Trp Ile Asp Ala Ser Trp Ala Ala Arg Phe Ala Gin Met Leu Glu Arg 25 Ala Glu Ala Arg Leu Ile Glu Gin Asp His Gly Gin Phe Glu Pro Ser 40 Leu Thr Val Glu Asp Gly Val Asp Lys Leu Val Ala Ala Tyr Pro His 55 Ala Ala Thr Asp Leu Leu Thr Pro Ala Asp Val Ala Trp Phe Leu Gly 70 75 Leu Cys Arg Thr Pro Gly Lys Pro Val Asn Phe Val Pro Val Ile Asp 90 Lys Asp Val Arg Arg Trp Trp Arg Ser Asp Ser Leu Trp Gin Ser His 100 105 110 Asp Asp Arg Tyr Thr Ala Asp Gin Val Ala Ile Ile Pro Gly Val Val 115 120 125 Ala Val Ala Gly Ile Thr Lys Ala Asn Glu Pro Val Ala Asp Leu Leu 130 135 140 Asp Arg Phe Val Asp Ala Thr Ile Glu Arg Ile Asp Glu His Asp Ser 145 150 155 160 Arg Ser Arg Asp Ile Met Gly Lys Val Leu Ser Ser Pro Gly Thr Phe 165 170 175 Trp Ala Gly Arg Asn Ile Pro Ser Val Ile His Ser Leu Gly His Ala 180 185 190 Asp Lys Trp Ser Arg Ser Glu Phe Glu Ala Phe His Ser Pro Thr Gly 195 200 205 Ala Asn Leu Val Tyr Glu Asp Ala Glu His Ala Met Leu Thr Val Pro 210 215 220 Leu Ala Gly Ser Thr Ala Phe Gly Thr Thr Ala Glu Leu Lys Ile Arg 225 230 235 240 Phe Thr Ser Pro Ile Asp Ala Leu Pro Ser Ala Val Pro Leu Val Thr 245 250 255 Gin Glu Asp Ala Glu Ala Ala Met Gly Glu Leu Thr Arg Ile Ala Ala 260 265 270 Gly Gly Thr Leu Ala Thr Val Asn Asn Gly Thr Ala Thr Trp Glu Thr 275 280 285 M^/ Ser Val Asp Ala Gly Val Ile Ala Asp Tyr Asn Asn Val Thr Ala Gly 290 295 300 Tyr Leu Pro Ala Ser Val Val Pro Ala His Thr Ala Pro Asp Val Leu 305 310 315 320 Val Gly Arg Ala Trp Pro Ala Val Phe Ala Ala Val Lys Ser Ala Val 325 330 335 Ile Pro Gly Thr Asp Ser Ala Ser Val Val Glu Gly Met Leu Ser Leu 340 345 350 Val His Leu Glu His His Ile Val Leu Lys Ser Asp Val Pro Thr Asp 355 360 365 Gly Ala Leu Lys Val Ser Ala Thr Ala Asp Glu Val Val Asp Thr Asp 370 375 380 Leu Gly Arg Leu Val Ile Val Arg Ala Glu Ile Ala Asp Ala Glu Gly 385 390 395 400 Asn Leu Ile Ala Thr Leu Ala Glu Arg Phe Ala Ile Arg Gly Arg Lys 405 410 415 Gly Asn Ala Val Ala Arg Thr Asn Thr Ser Ala Leu Pro Thr Thr Val 420 425 430 Asp Thr Pro Arg Ser Ala Arg Ala Val Ala Thr Val Val Ala Pro Glu 435 440 445 Ser Met Arg Pro Phe Ala Val Ile Ser Gly Asp Arg Asn Pro Ile His 450 455 460 Val Ser Asp Val Ala Ala Ser Leu Ala Gly Leu Pro Gly Val Ile Val 465 470 475 480 His Gly Met Trp Thr Ser Ala Ile Gly Glu Leu Ile Ala Gly Ala Ala 485 490 495 Phe Asn Asp Glu Gin Ile Gin Thr Pro Ala Ala Lys Val Val Glu Tyr 500 505 510 Thr Ala Thr Met Leu Ala Pro Val Leu Pro Gly Glu Glu Ile Glu Phe 515 520 525 Ser Val Glu Arg Ser Ala Val Asp Asn Arg Pro Gly Met Gly Glu Val 530 535 540 Arg Thr Val Thr Ala Thr Val Asn Gly Asn Leu Val Leu Thr Ala Thr 545 550 555 560 Ala Val Val Ala Ala Pro Ser Thr Phe Tyr Ala Phe Pro Gly Gin Gly 565 570 575 Ile Gin Ser Gin Gly Met Gly Met Glu Ala Arg Arg Asn Ser Gin Ala 580 585 590 Ala Arg Ala Ile Trp Asp Arg Ala Asp Ala His Thr Arg Asn Lys Leu 595 600 605 Gly Phe Ser Ile Val Glu Ile Val Glu Asn Asn Pro Arg Glu Val Thr 114 610 Val Ala 625 Gin Phe Glu Met His Ser Ser Leu 690 His Arg 705 Ala Ala Asp Tyr Val Asn Ala Gly 770 Gin Arg 785 Ser Lys Leu Ile Pro Asn Ser Met 850 Asp Phe 865 Leu Ile Glu Thr Glu Val Thr Leu Gly Glu Lys Phe Thr Arg Val1 675 Glu Leu Le u ValI Tyr 755 Leu Al a Leu Pro Le u 835 Ala Lys Giu Gin Gi y 915 Arg Gin Glu 660 Gly Ser Val1 Arg Ala 740 As n Ala Phe Arg Al a 820 Val1 Glu Ala Le u Asp 900 ValI Le u Val1 645 Al a Glu Val1 Asp Pro 725 Ser Leu Ala Ile Asp 805 Giu Al a Val1 Ala Leu 885 Leu Gly Pro 630 Gly His Tyr Leu Arg 710 As n Val1 Al a Leu Leu 790 Gly Leu Arg Val1 Se r 870 Ala Le u Ser Gin 615 Phe Met Ala Asn Giu 695 Asp Lys Ser Gly Arg 775 Ile Val1 Asp Pro Glu 855 Ala Trp Ile Ala T yr 935 His Pro Asp Ala Leu Al a 680 Ile Glu Met Glu Le u 760 Al a Pro Gi y Le u Phe 840 Ser Asp Gin Lys Pro 920 Al a Thr As n 665 Le u Val As n Gi y Al a 745 Gin Asp Gi y Ala Asp 825 Glu Thr Lys Phe Gly 905 Thr Asp Le u 650 Gin Ala Tyr Gly Le u 730 Ser Tyr ValI Ile Phe 810 Val1 Leu Tyr Gin Ala 890 Le u Leu Al a Gi y 635 Gly Arq Ala Arq Le u 715 Thr Gly Al a Glu Asp 795 Arq Le u Thr Val1 Lys 875 Ser Gin Al a Thr 620 Val1 Val1 Ala Tyr Arg 700 Ser Ala Glu Val1 Asn 780 ValI Giu Val1 Glu Asn 860 Leu Pro Al a Asn Ile 940 Leu Tyr Leu Thr Ala Tyr Ala 685 Gly Asn Asp Phe Ala 765 Arg Pro His Gly Giu 845 Glu Al a Val1 Glu Met 925 Glu Ile 655 Ala Vali Thr Ala Val 735 Giu Thr Pro His Asp 815 Tyr Val Leu Thr T rp 895 Phe Gly Leu 640 Ala Gly Leu Met Leu 720 Phe Ile Gin Gly Ser 800 Ser Ile Ala Al a Le u 880 Ile Val1 Gin Asn Ile Glu Arg Asp Arg Pro Val Val Phe Ala Thr Asp Glu Val Val Arg 945 950 955 960 Glu Val Ala Val Glu Glu Thr Pro Ala Ala Pro Ala Glu Thr Thr Glu 965 970 975 Thr Pro Ala Thr Pro Ala Thr Pro Ala Pro Val Ala Ala Ala Ala Pro 980 985 990 Ala Thr Gly Gly Pro Arg Pro Asp Asp Ile Ser Phe Thr Pro Ser Asp 995 1000 1005 Ala Thr Glu Met Leu Ile Ala Ile Trp Thr Lys Val Arg Pro Asp Gin 1010 1015 1020 Met Gly Ala Thr Asp Ser Ile Glu Thr Leu Val Glu Gly Val Ser Ser 1025 1030 1035 1040 Arg Arg Asn Gin Leu Leu Leu Asp Leu Gly Val Glu Phe Gly Leu Gly 1045 1050 1055 Ala Ile Asp Gly Ala Ala Asp Ala Glu Leu Gly Asp Leu Lys Val Thr 1060 1065 1070 Val Ser Lys Met Ala Lys Gly Tyr Lys Ala Phe Gly Pro Val Leu Ser 1075 1080 1085 Asp Ala Ala Ala Asp Ala Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys 1090 1095 1100 Arg Pro Gly Tyr Ile Ala Glu Arg Val Thr Gly Thr Trp Glu Leu Gly 1105 1110 1115 1120 Gin Gly Trp Ala Asp His Val Val Ala Glu Val Val Ile Gly Ala Arg 1125 1130 1135 Glu Gly Ala Ser Leu Arg Gly Gly Asp Leu Ala Ser Leu Ser Pro Ala 1140 1145 1150 Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu Ile Asp Ala Ala Val 1155 1160 1165 Gin Ala Val Ala Ser Arg Arg Gly Val Ala Val Ser Leu Pro Ser Ala 1170 1175 1180 Gly Gly Ala Ala Gly Gly Val Val Asp Ser Ala Ala Leu Gly Glu Phe 1185 1190 1195 1200 Ala Glu Gln Val Thr Gly His Asp Gly Val Leu Ala Gin Ala Ala Arg 1205 1210 1215 Thr Ile Leu Thr Gin Leu Gly Leu Asp Lys Pro Ala Thr Val Ser Val 1220 1225 1230 Glu Asp Thr Ala Glu Glu Asp Leu Tyr Glu Leu Val Ser Lys Glu Leu 1235 1240 1245 Gly Ser Asp Trp Pro Arg Gin Val Ala Pro Ser Phe Asp Glu Glu Lys 1250 1255 1260 Val Val Leu Leu Asp Asp Arg Trp Ala Ser Ala Arg Glu 1265 1270 1275 (210> (211> 4953 <212> DNA <213> Corynebacterium giutamicun <2 <221> CDS <223> RXA02582 (400> tggatgteta ttctcctcag cctegttttg gttgaggcgg atagttttaa tattttttta agtttaagtt gtaatcgage tgaaaggctg aggcctcaat atg gaa cag age caa Met Giu Gin Ser Gin tcg teg gat cag Ser Ser Asp Gin aag Lys atg acc gtt gaa Met Thr Val Giu cag Gin 15 gtt cgc ace: tgg Val Arg Thr Trp ctc cgt Leu Arg gat tgg gtt Asp Trp Vai gac aag gca Asp Lys Ala cgc acc acg ggt Arg Thr Thr Gly ccg gtg gag gaa Pro Val Giu Glu gtt acg gat Val Thr Asp gtt gtt gtg Val Val Val atg gag ace ttt Met Giu Thr Phe ctt tcc tct cge Leu Ser Ser Arg ga t Asp so ttg tcc Leu Ser ggt gag ctg gaa Gly Giu Leu Giu aae Asn ctg ctg gac ace Leu Leu Asp Thr ttg gat gcc ace Leu Asp Ala Thr ate Ile get tat gag tac: Ala Tyr Glu Tyr cca Pro acg atc cgt agt Thr Ile Arg Ser gcg cag cgc ctt Ala Gin Arg Leu gag ggc gag cct Giu Gly Giu Pro Cgt Arg egt gca cat acc Arg Ala His Thr cag Gin 95 cgt gaa ttg aat Arg Giu Leu Asn ttc tcc Phe Ser 100 gcg gtg age Ala Vai Ser get gcg cgt Ala Ala Arg 120 ga t Asp 105 tcc: cca ggt tee Ser Pro Gly Ser gat att gcg gtt Asp Ile Ala Val gte: ggt atg Val Gly Met 115 tgg aag eta Trp Lys Leu tac eca ggc get Tyr Pro Gly Ala age ctg gag gat Ser Leu Giu Asp etc gte Leu Val 135 gag ggc egt gac Giu Gly Arg Asp ate teg gat eta Ile Ser Asp Leu e eq Pro 145 att gge cgt tgg Ile Gly Arg Trp tet Ser 150 gag tat gea gge Giu Tyr Ala Gly ga t Asp gag gtt atg tet Glu Val Met Ser aag atg gaa gag Lys Met Giu Giu tct aco atc ggt Ser Thr Ile Giy qg c Gly 170 tac otg tca gat Tyr Leu Ser Asp tct agc ttt gat Ser Ser Phe Asp gcg gag Ala Glu 180 ttc ttt ggt Phe Phe Gly ogt att ttg Arg Ile Leu 200 tct ccg ctc gag Ser Pro Leu Giu gcc aac atg gat Ala Asn Met Asp oct cag cag Pro Gin Gin 195 got. ogc atc Ala Arg Ile ctg gag cia acg Leu Giu Leu Thr tgg Trp, 205 gag got ttg gag Giu Ala Leu Glu tac Tyr 210 gca cca Ala Pro 215 aac act tig ogt Asn Thr Leu Arg gaa goc gig ggc Glu Ala Val Gly to ata ggi too Phe Ile Gly Ser too Ser 230 aao aac gat tao Asn Asn Asp Tyr ggc Gly 235 atg atg ato got Met Met Ile Ala gc Al a 240 gat oca gca gaa Asp Pro Ala Giu oat Oct tat gog His Pro Tyr Ala act ggt act tot Thr Gly Thr Ser gog att gtc got Ala Ile Val Ala aac ogo Asn Arg 260 ati aac tao Ile Asn Tyr gca tgt tot Ala Cys Ser 280 got Ala 265 tto gat tto ogo Phe Asp Phe Arg ggt Gly 270 cot too gto aac Pro Ser Val Asn gtg gat aco Val Asp Thr 275 ogi gog cig Arg Ala Leu tot tot otg gta Ser Ser Leu Val git cac oag got Val His Gin Ala cgt aat Arg Asn 295 ggc gaa gog gat Gly Glu Ala Asp got atc got ggt Ala Ile Ala Gly gtg aac ati tig Val Asn Ile Leu tot coa ttt gto Ser Pro Phe Val aca Thr 315 act gca tto got Thr Ala Phe Ala gag Glu 320 oto ggt gig ato Leu Gly Val Ile ago Ser 325 1027 1075 1123 oca aco ggo aag Pro Thr Gly Lys oao goa tto tot His Ala Phe Ser gat goc gat ggt Asp Ala Asp Gly tto gig Phe Val 340 ogt tco gao Arg Ser Asp ato ogo gao Ile Arg Asp 360 goo gga gto gt Ala Gly Val Val gt g Val1 350 cig aag cgo gtg Leu Lys Arg Val gat gac gca Asp Asp Ala 355 tot goa gig Ser Ala Val 1171 1219 ggo gao aag ato Gly Asp Lys Ile ggt gtg ato aag Gly Val Ile Lys ggt Gly 370 aac icc Asn Ser 375 gat ggt oao too Asp Gly His Ser gga otg aco got Gly Leu Thr Ala aac cot gao goa Asn Pro Asp Ala 1267 1315 git gat gtg otg Val Asp Val Leu oag Gin 395 ogt goa tat gti Arg Ala Tyr Val gao Asp 400 got cag gtt gat Ala Gin Val Asp cco Pro 405 aco aco gig gat tao gtt gag got oao ggo aoo ggo aco ato ctg ggt 16 1363 Thr Thr Val Asp Thr Tr Va Asp Val Glu Ala His ThGl Tr i Thr Gly Thr Ile Leu Gly 420 gac ccc att Asp Pro Ile gac gca tcc Asp Ala Ser 440 gaa Glu 425 gca act gcc ctg Ala Thr Ala Leu ggt Gly 430 gct gtt ttg ggc Ala Val Leu Gly tat ggc cgt Tyr Gly Arg 435 aac ttc ggc Asn Phe Gly 1411 1459 acc cca act ctt Thr Pro Thr Leu gqc tct goa aag Gly Ser Ala Lys too Ser 450 cac act His Thr 455 gag tca gct gcg Glu Ser Ala Ala ggt Gly 460 att gca ggt gtc Ile Ala Gly Val aag gtg ctg ctt Lys Val Leu Leu gct Al a 470 ttg cag aac aag Leu Gin Asn Lys ctg cca oca acc Leu Pro Pro Thr aac ttt gca ggt Asn Phe Ala Gly cca Pro 485 1507 1555 1603 aac 090 tac atc Asn Arg Tyr Ile ga t Asp 490 ttc gat got gag Phe Asp Ala Glu cgt Arg 495 ttg gaa gtt gtg Leu Glu Val Val gaa gat Glu Asp 500 cca cgt gaa Pro Arg Giu gcg ttc ggg Ala Phe Gly 520 cog gaa tao aac Pro Glu Tyr Asn cac gos gta got His Ala Val Ala ggt gtg tct Gly Val Ser 515 tct gag tao Ser Glu Tyr 1651 1699 ttc ggt gga aco Phe Gly Gly Thr aac As n 525 gcg cac gtg gtg Ala His Val Val aao goa Asn Ala 535 gaa gao tao gaa Glu Asp Tyr Glu ogt goo cog aag Arg Ala Pro Lys gcg ttg ott oot Ala Leu Leu Pro cag cag gtt gc Gin Gin Val Ala ct g Leu 555 cog gtg tot ggt Pro Val Ser Gly ctg cca too agg Leu Pro Ser Arg 1747 1795 1843 oga caa gca got Arg Gln Ala Ala gao ttg gcg gao Asp Leu Ala Asp ttc Phe 575 ttg gag ggc ogo Leu Giu Gly Arg aaa gat Lys Asp 580 tgo gao ota Cys Asp Leu ogo tco ogo Arg Ser Arg 600 oca gta goc ogo Pro Val Ala Arg ctg gca ggc ogo Leu Ala Gly Arg aat cat ggc Asn His Gly 595 gcc gta aag Ala Val Lys 1891 1939 goa gto gtg ott Ala Val Val Leu gca Al a 605 ago act atc gag Ser Thr Ile Glu ogo ctg Arg Leu 615 090 cag gto goa Arg Gin Val Ala ggc aag gtc ago Giy Lys Vai Ser gyt ato too gca Gly Ile Ser Ala 1987 2035 got Ala 630 gat too oca gog Asp Ser Pro Ala gc Al a 635 aac ggt cot gtg Asn Gly Pro Val gtg tao too ggt Val Tyr Ser Gly gga too cag cac ogo oto atg atc aag gaa ttg tgo tca att tog oca Gly Ser Gin His Arg Leu Met Ile Lys Giu Leu Cys Ser Ile Ser Pro 2083 cag ttc ogo Gin Phe Arg tcc ggo tg9 Ser Gly Trp 680 gag Glu 665 cgc atc gaa gag Arg Ile Glu Giu gat gaa atg gtt Asp Giu Met Val aag ttc gag Lys Phe Glu 675 caa act tac Gin Thr Tyr 2131 2179 too ato atg aaa Ser Ile Met Lys gtt ttg gat gat Val Leu Asp Asp gao acc Asp Thr 695 gag acc gcg cag Giu Thr Ala Gin gtg atc acc gca Vai Ile Thr Ala atc Ile 705 cag atc gca ctg Gin Ile Ala Leu gac ctg ttg gca Asp Leu Leu Ala agc Ser 715 tto ggt gta aag Phe Gly Val Lys gct gco gto atg Ala Ala Val Met 2227 2275 2323 atg tcg atg ggt Met Ser Met Gly atc got gco gct Ile Ala Ala Ala gct gcc ggt gga Ala Ala Gly Gly otc ago Leu Ser 740 gac 090 gat Asp Arg Asp gag ggc gag Giu Giy Giu 760 atg ctc att gcc Met Leu Ile Ala agc Ser 750 cac cgt tco cgc His Arg Ser Arg ota atg ggc Leu Met Gly 755 atg gct gtg Met Ala Val 2371 2419 aag tcc ctg got Lys Ser Leu Ala gat cag ctg ggt Asp Gin Leu Gly gc Ala 770 gtg gaa Val Giu 775 ttc 9CC gct gcg Phe Ala Ala Ala gao Asp 780 otg gat aag ttc Leu Asp Lys Phe gaa gaa aao cct Giu Giu Asn Pro gag Giu 790 tao aag ggc att Tyr Lys Gly Ile cot got gtt tat Pro Ala Val Tyr ggo oca ggo atg Gly Pro Gly Met aot Thr 805 2467 2515 2563 aco gtg ggt gga Thr Val Gly Gly oot Pro 810 ogo gao goc gtg Arg Asp Ala Val oag tto gta gag Gin Phe Val Giu aag otg Lys Leu 820 gaa tct gaa Giu Ser Giu oao aoo tct His Thr Ser 840 aag ttt goc ogo Lys Phe Ala Arg oto aao gtc aag Leu Asn Val Lys ggc got ggo Gly Ala Gly 835 ggo gaa ato Gly Glu Ile 2611 2659 got gtg gaa oca Ala Val Giu Pro ctt Leu 845 ott ggt gag otc Leu Gly Glu Leu got ggo Ala Gly 855 ato gag oca ott Ile Glu Pro Leu otg cag ato oog Leu Gin Ile Pro ttg Leu 865 tto ago tot gtc Phe Ser Ser Val oag ggt gtt aoo Gin Gly Val Thr tao Tyr 875 ooa gtt gga goa Pro Val Gly Ala gto cao gao goo Val His Asp Ala 2707 2755 2803 tao atg ctc cgc Tyr Met Leu Arg aoo ogc oag too Thr Arg Gin Ser tao tto oag gao Tyr Phe Gin Asp too aoo Ser Thr 900 gaa gct gca Glu Ala Ala aac oca gtt Asn Pro Val 920 ttc Phe 905 gict gca ggc cac Ala Ala Gly His acc ttg gtq qaa Thr Leu Val Glu att too ccg Ile Ser Pro 915 acc gtg ggc Thr Val Gly 2851 2899 gca ctc atg ggc Ala Leu Met Gly atg aac aco gog Met Asn Thr Ala ttc Phe 930 aag cct Lys Pro 935 gat gca cag otg Asp Ala Gin Leu ctg Leu 940 ttc agc otg aag Phe Ser Leu Lys cga Arg 945 aaa gtc coa gag Lys Val Pro Glu gaa toc ctc cgc Glu Ser Leu Arg gao Asp 955 ott ctg gcg aag Leu Leu Ala Lys tac gtc aac ggc Tyr Val Asn Gly 2947 2995 3043 aac gtt gat ttc Asn Val Asp Phe too Ser 970 gcg otg tac ggc Ala Leu Tyr Gly gaa Glu 975 ggt gaa acc atc Gly Glii Thr Ile gat ccg Asp Pro 980 cca oac atc Pro His Ile tgg aag cac cag Trp Lys His Gin ttc tgg aot too goa ogo oca Phe Trp Thr Ser Ala Arg Pro 995 ggo ttc ogc gtg aat otg cca Gly Phe Arg Val Asn Leu Pro 1010 3091 3139 too tot gqo goa Ser Ser Gly Ala 1000 too otg gat Ser Leu Asp otg cog Leu Pro 1005 aao aao aot gtg gog ttt Asn Asn Thr Val Ala Phe 1015 too aoo Ser Thr 1020 goa goc gaa Ala Ala Giu otg goa Leu Ala 1025 oca too goa Pro Ser Ala gtg goa ato atg gaa Val Ala Ile Met Glu 1030 gca gc Ala Ala 1035 goc atg got Ala Met Ala gto aoo Val Thr 1040 oca ggt too too Pro Gly Ser Ser 3187 3235 1045 3283 gto gao goa gtg Val Asp Ala Val gao gag ogo gao atg Asp Giu Arg Asp Met 1050 otg oca Leu Pro 1055 oca ago ggo Pro Ser Gly gaa ato Glu Ile 1060 a00 aoo atc Thr Thr Ile gtg act Val Thr 1065 ogo too ttg gyc ggt ttg ago otg too gta tao Arg Ser Leu Gly Gly Leu Ser Leu Ser Val Tyr 3331 1070 1075 aag att gag gga Lys Ile Giu Gly 1080 aao ooa gga tto Asn Pro Gly Phe 1095 aoc aoo ago act ott Thr Thr Ser Thr Leu 1085 goo goa gca tot tc Ala Ala Ala Ser Ser 1100 gto goo gaa Val Ala Glii ggt tto goa goo Gly Phe Ala Ala 1090 3379 tto gao ggt ooa ggo tao gao Phe Asp Gly Pro Gly Tyr Asp 1105 3427 gga tto aao aoo gat Gly Phe Asn Thr Asp 1110 tao ago gao cag oca gao cot ogo too gao otg Tyr Ser Asp Gin Pro Asp Pro Arg Ser Asp Leu 1115 1120 3475 1125 3523 cot ttg gao ato gaa goa gto ogo tgg gao ooa gog aoo gaa aoo gto Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro Ala Thr Glu Thr Val 1130 1135 1140 gaa gag cgc atg ogc goc atc gtc tcc gaa gca atg ggc tac gac gtg 3571 Giu Giu Arg Met Arg Ala Ile Val Ser Glu Ala Met Giy Tyr Asp Val 1145 1150 1155 gat gao ctc cca ogo gaa cto cca otg att gao ctc ggc otc gac tcc 3619 Asp Asp Leu Pro Arg Giu Leu Pro Leu Ile Asp Leu Gly Leu Asp Ser 1160 1165 1170 ctc atg ggc atg cgc atc aaa aac cgc atc gaa aat gac ttc cag atc 3667 Leu Met Gly Met Arg Ile Lys Asn Arg Ile Giu Asn Asp Phe Gin Ile 1175 1180 1185 cca cca ctc cag gto oaa gcg otc cgc gat gca toc gtc got gac gtg 3715 Pro Pro Leu Gin Val Gin Ala Leu Arg Asp Ala Ser Val Ala Asp Val 1190 1195 1200 1205 gta ato atg Val Ile Met gtc gao goc Val Asp Ala gtg gaa aac Val Giu Asn 1210 atg gtc gct Met Val Ala ggc cgc Gly Arg 1215 too tot gag acg ott Ser Ser Glu Thr Leu 1220 3763 aco oog Thr Pro 1225 oag gtg ooa Gin Val Pro got gag Ala Glu 1230 goa goa ggg Ala Ala Giy gag got oaa Giu Ala Gln 1235 3811 3859 got gct gag tot Ala Ala Glu Ser 1240 tct got tog Ser Ala Ser ggc gag Gly Glu 1245 gac gtg cag Asp Val Gin ggc gtt ggc gtt Gly Val Gly Val 1250 goa oog Ala Pro 1255 ctg act Leu Thr 1270 cga gat gog tog Arg Asp Ala Ser gaa ogo atg gto ttt Giu Arg Met Val Phe 1260 ggt aot Gly Thr 1265 tgg goa ggo Trp Ala Gly 3907 ggc got gcg Gly Ala Ala gca gct Ala Ala 1275 ggo gtg aoo Gly Vai Thr ago aag Ser Lys 1280 ttg cca oag ato 3~ Leu Pro Gin Ile 1285 955 gat gto gat act Asp Val Asp Thr goa aco goa att cc Ala Thr Ala Ile Ala 1290 gag ogo Glu Arg 1295 oto aoo gag Leu Thr Glu ogt too Arg Ser 1300 4003 4051 gga att gaa ato ago aot Giy Ile Giu Ile Ser Thr 1305 coa otg tot gac ctg gtg Pro Leu Ser Asp Leu Val 1320 aao att ogt gtg otg ogt Asn Ile Arg Val Leu Arg 1335 gaa oag gtg ttg Giu Gin Val Leu 1310 got gca gaa Ala Ala Glu aoo oto gaa Thr Leu Glu 1315 ogt gaa ggo oto gaa act gaa qtt oag ggo Arg Glu Gly Leu Glu Thr Glu Val Gin Gly 1325 1330 gga ogt goa gaa ggo too aoo aag oot goa Gly Arg Ala Giu Giy Ser Thr Lys Pro Ala 1340 1345 4099 4147 gtg tto atg tto oao ooa got ggo ggt tot Val Phe Met Phe His Pro Ala Gly Gly Ser 1350 1355 too gtg gto tao caa ooa Ser Val Val Tyr Gin Pro 1360 4195 1365 4243 ota atg cgt cgt ctg cct gaa gat gtc cot gto tat ggc gtt gag ogt Leu Met Arg Arg Leu Pro Giu Asp Val Pro Val Tyr Gly Val Giu Arg 1370 1375 1380 ctg gaa ggo gat oto got gao ogo gog goa goa tat gtt gat gao ato 4291 Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala Tyr Val Asp Asp Ile 1385 1390 1395 aag aag tao tcc gat ggc ttc cca gta gtt ttg ggt ggc tgg agc ttc Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu Gly Gly Trp Ser Phe 1400 1405 1410 ggc ggt gee gtt gcc ttc gag gtt gcc cac caa ctg gtt ggc tcc qat Gly Gly Ala Val Ala Phe Giu Val Ala His Gin Leu Val Gly Ser Asp 1415 1420 1425 4339 4387 gtt gag gta get Val Glu Val Ala 1430 ace gtg gcg ttg ctg gat act gtg cag cct tca aac Thr Val Ala Leu Leu Asp Thr Val Gin Pro Ser Asn 1435 1440 4435 1445 4483 eca gca eca gat ace gct gag gaa act cgt gca ego tgg act Pro Ala Pro Asp Thr Ala Glu Glu Thr Arq Ala Arg Trp Thr 1450 1455 cgc tac Arg Tyr 1460 geg gac tte Ala Asp Phe gcc aag Ala Lys 1465 aag ace tao Lys Thr Tyr ggc ett Gly Leu 1470 gat ttc gag Asp Phe Glu gta oct ttt Val Pro Phe 1475 4531 4579 gaa ate ttg gac Giu Ile Leu Asp 1480 ace ate ggt Thr Ile Gly gaa gac Giu Asp 1485 gga atg etg Gly Met Leu tee atg atg ace Ser Met Met Thr 1490 gao ttc Asp Phe 1495 gtg ctt Val Leu 1510 ctg gcc aac ace gao Leu Ala Asn Thr Asp 151 gee Ala 00 tee gag eac Ser Glu His gga Gi y ttg tee gca ggt Leu Ser Ala Gly ege ate etg get Arg Ile Leu Ala 4627 4 67 1525 gaa cac cag Glu His Gin Cge get Arg Ala 1515 tet ttt gtg Ser Phe Val gac aae Asp Asn 1520 aaa ott aat Lys Leu Asn ttCcego geg Phe Arg Ala ttt gea gao Phe Ala Asp 1530 tgg gee aac Trp Ala Asn gtt gaa Val Giu 1535 gee oct gte Ala Pro Val ate etg Ile Leu 1540 4723 gaa ego Giu Arg 1545 atg eat gat gga get ate gaa ott M'et His Asp Gly Ala Ile Giu Leu 1550 gaa eca. aae Giu Pro Asn 1555 4771 tat gee aag att Tyr Ala Lys Ile 1560 ttg gaa att gtt Leu Giu Ile Val 1575 gat caa gat gga gga tgg tee gga att gte aae gat Asp Gin Asp Gly Gly Trp Ser Gly Ile Val Asn Asp 4819 1565 1570 eag etg aat ggt gao cac Gin Leu Asn Gly Asp His 1580 ctg gca gtt gte gat gaa Leu Ala Val Val Asp Glu 1585 4867 eca gaa ate gge aca Pro Glu Ile Gly Thr 1590 att tot egg aag aat Ile Ser Arg Lys Asn gte gga get eat ttg agt ego ego att gat gag 4915 Val Gly Ala His Leu Ser Arg Arg Ile Asp Giu 1595 1600 1605 tagtaaegga gagetgacgg aag 4953 1610 <210> 56 <211> 1610 <212> PRT <213> Corynebacterium glutamicum <400> 56 Met Glu Gin Ser Gin Ser Ser Asp Gin Lys Met Thr Val Glu Gin Val 1 5 10 Arg Thr Trp Leu Arg Asp Trp Val Val Arg Thr Thr Gly Ile Pro Val 25 Glu Glu Val Thr Asp Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser 40 Arg Asp Val Val Val Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr 55 Ser Leu Asp Ala Thr Ile Ala Tyr Glu Tyr Pro Thr Ile Arg Ser Leu 70 75 Ala Gin Arg Leu Val Glu Gly Glu Pro Arg Arg Ala His Thr Gin Arg 90 Glu Leu Asn Phe Ser Ala Val Ser Asp Ser Pro Gly Ser His Asp Ile 100 105 110 Ala Val Val Gly Met Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu 115 120 125 Asp Met Trp Lys Leu Leu Val Glu Gly Arg Asp Gly Ile Ser Asp Leu 130 135 140 Pro Ile Gly Arg Trp Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg 145 150 155 160 Lys Met Glu Glu Phe Ser Thr Ile Gly Gly Tyr Leu Ser Asp Ile Ser 165 170 175 Ser Phe Asp Ala Glu Phe Phe Gly Leu Ser Pro Leu Glu Ala Ala Asn 180 185 190 Met Asp Pro Gin Gin Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu 195 200 205 Glu Tyr Ala Arg Ile Ala Pro Asn Thr Leu Arg Gly Glu Ala Val Gly 210 215 220 Val Phe Ile Gly Ser Ser Asn Asn Asp Tyr Gly Met Met Ile Ala Ala 225 230 235 240 Asp Pro Ala Glu Ala His Pro Tyr Ala Leu Thr Gly Thr Ser Ser Ala 245 250 255 Ile Val Ala Asn Arg Ile Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser 260 265 270 Val Asn Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Val His Gin 275 280 285 Ala Val Arg Ala Leu Arg Asn Gly Glu Ala Asp His Ala Ile Ala Gly 290 295 300 Gly Val Asn Ile Leu Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu 305 310 315 320 Leu Gly Val Ile Ser Pro Thr Gly Lys Ile His Ala Phe Ser Asp Asp 325 330 335 Ala Asp Gly Phe Val Arg Ser Asp Gly Ala Gly Val Val Val Leu Lys 340 345 350 Arg Val Asp Asp Ala Ile Arg Asp Gly Asp Lys Ile Ile Gly Val Ile 355 360 365 Lys Gly Ser Ala Val Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala 370 375 380 Pro Asn Pro Asp Ala Gin Val Asp Val Leu Gin Arg Ala Tyr Val Asp 385 390 395 400 Ala Gin Val Asp Pro Thr Thr Val Asp Tyr Val Glu Ala His Gly Thr 405 410 415 Gly Thr Ile Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Gly Ala Val 420 425 430 Leu Gly Tyr Gly Arg Asp Ala Ser Thr Pro Thr Leu Leu Gly Ser Ala 435 440 445 Lys Ser Asn Phe Gly His Thr Glu Ser Ala Ala Gly Ile Ala Gly Val 450 455 460 Ile Lys Val Leu Leu Ala Leu Gin Asn Lys Thr Leu Pro Pro Thr Val 465 470 475 480 Asn Phe Ala Gly Pro Asn Arg Tyr Ile Asp Phe Asp Ala Glu Arg Leu 485 490 495 Glu Val Val Glu Asp Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Ala 500 505 510 Val Ala Gly Val Ser Ala Phe Gly Phe Gly Gly Thr Asn Ala His Val 515 520 525 Val Ile Ser Glu Tyr Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys 530 535 540 Glu Ala Leu Leu Pro Asp Gin Gin Val Ala Leu Pro Val Ser Gly His 545 550 555 560 Leu Pro Ser Arg Arg Arg Gin Ala Ala Ala Asp Leu Ala Asp Phe Leu 565 570 575 Glu Gly Arg Lys Asp Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala 580 585 590 Gly Arg Asn His Gly Arg Ser Arg Ala Val Val Leu Ala Ser Thr Ile 595 600 605 Glu Glu Ala Val Lys Arg Leu Arg Gin Val Ala Glu Gly Lys Val Ser 610 615 620 Val Gly Ile Ser Ala Ala Asp Ser Pro Ala Ala Asn Gly Pro Val Phe 625 630 635 640 Val Tyr Ser Gly Phe Gly Ser Gin His Arg Leu Met Ile Lys Glu Leu 645 650 655 Cys Ser Ile Ser Pro Gin Phe Arg Glu Arg Ile Glu Glu Leu Asp Glu 660 665 670 Met Val Lys Phe Glu Ser Gly Trp Ser Ile Met Lys Leu Val Leu Asp 675 680 685 Asp Glu Gin Thr Tyr Asp Thr Glu Thr Ala Gin Val Val Ile Thr Ala 690 695 700 Ile Gin Ile Ala Leu Thr Asp Leu Leu Ala Ser Phe Gly Val Lys Pro 705 710 715 720 Ala Ala Val Met Gly Met Ser Met Gly Glu Ile Ala Ala Ala Tyr Ala 725 730 735 Ala Gly Gly Leu Ser Asp Arg Asp Thr Met Leu Ile Ala Ser His Arg 740 745 750 Ser Arg Leu Met Gly Glu Gly Glu Lys Ser Leu Ala Glu Asp Gin Leu 755 760 765 Gly Ala Met Ala Val Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe 770 775 780 Ile Glu Glu Asn Pro Glu Tyr Lys Gly Ile Glu Pro Ala Val Tyr Ala 785 790 795 800 Gly Pro Gly Met Thr Thr Val Gly Gly Pro Arg Asp Ala Val Val Gin 805 810 815 Phe Val Glu Lys Leu Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn 820 825 830 Val Lys Gly Ala Gly His Thr Ser Ala Val Glu Pro Leu Leu Gly Glu 835 840 845 Leu Ala Gly Glu Ile Ala Gly Ile Glu Pro Leu Pro Leu Gin Ile Pro 850 855 860 Leu Phe Ser Ser Val Asp Gin Gly Val Thr Tyr Pro Val Gly Ala Val 865 870 875 880 Val His Asp Ala Asp Tyr Met Leu Arg Cys Thr Arg Gin Ser Val Tyr 885 890 895 Phe Gin Asp Ser Thr Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu 900 905 910 Val Glu Ile Ser Pro Asn Pro Val Ala Leu Met Gly Met Met Asn Thr 915 920 925 Ala Phe Thr Val Gly Lys Pro Asp Ala Gin Leu Leu Phe Ser Leu Lys 930 935 940 Arg Lys Val Pro Glu Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu 945 950 955 960 Tyr Val Asn Gly Ala Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly 965 970 975 Glu Thr Ile Asp Pro Pro His Ile Thr Trp Lys His Gln Arg Phe Trp 980 985 990 Thr Ser Ala Arg Pro Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe 995 1000 1005 Arg Val Asn Leu Pro Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu 1010 1015 1020 Leu Ala Pro Ser Ala Val Ala Ile Met Glu Ala Ala Ala Met Ala Val 1025 1030 1035 1040 Thr Pro Gly Ser Ser Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro 1045 1050 1055 Pro Ser Gly Glu Ile Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu 1060 1065 1070 Ser Leu Ser Val Tyr Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala 1075 1080 1085 Glu Gly Phe Ala Ala Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp 1090 1095 1100 Gly Pro Gly Tyr Asp Gly Phe Asn Thr Asp Tyr Ser Asp Gin Pro Asp 1105 1110 1115 1120 Pro Arg Ser Asp Leu Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro 1125 1130 1135 Ala Thr Glu Thr Val Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala 1140 1145 1150 Met Gly Tyr Asp Val Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp 1155 1160 1165 Leu Gly Leu Asp Ser Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu 1170 1175 1180 Asn Asp Phe Gin Ile Pro Pro Leu Gin Val Gin Ala Leu Arg Asp Ala 1185 1190 1195 1200 Ser Val Ala Asp Val Val Ile Met Val Glu Asn Met Val Ala Gly Arg 1205 1210 1215 Ser Ser Glu Thr Leu Val Asp Ala Thr Pro Gin Val Pro Ala Glu Ala 1220 1225 1230 Ala Gly Glu Ala Gin Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val 1235 1240 1245 Gin Gly Val Gly Val Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe 1250 1255 1260 Gly Thr Trp Ala Gly Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser 1265 1270 1275 1280 Lys Leu Pro Gin Ile Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg 1285 1290 1295 Leu Thr Glu Arg Ser Gly Ile Glu Ile Ser Thr Glu Gin Val Leu Ala 1300 1305 1310 Ala Glu Thr Leu Glu Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu 1315 1320 1325 Thr Glu Val Gin Gly Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly 1330 1335 1340 Ser Thr Lys Pro Ala Val Phe Met Phe His Pro Ala Gly Gly Ser Ser 1345 1350 1355 1360 Val Val Tyr Gin Pro Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val 1365 1370 1375 Tyr Gly Val Glu Arg Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala 1380 1385 1390 Tyr Val Asp Asp Ile Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu 1395 1400 1405 Gly Gly Trp Ser Phe Gly Gly Ala Val Ala Phe Glu Val Ala His Gin 1410 1415 1420 Leu Val Gly Ser Asp Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr 1425 1430 1435 1440 Val Gin Pro Ser Asn Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala 1445 1450 1455 Arg Trp Thr Arg Tyr Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp 1460 1465 1470 Phe Glu Val Pro Phe Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met 1475 1480 1485 Leu Ser Met Met Thr Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His 1490 1495 1500 Gly Leu Ser Ala Gly Val Leu Glu His Gin Arg Ala Ser Phe Val Asp 1505 1510 1515 1520 Asn Arg Ile Leu Ala Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu 1525 1530 1535 Ala Pro Val Ile Leu Phe Arg Ala Glu Arg Met His Asp Gly Ala lle 1540 1545 1550 Glu Leu Glu Pro Asn Tyr Ala Lys Ile Asp Gin Asp Gly Gly Trp Ser 1555 1560 1565 Gly Ile Val Asn Asp Leu Glu Ile Val Gin Leu Asn Gly Asp His Leu 1570 1575 1580 Ala Val Val Asp Glu Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser 1585 1590 1595 1600 Arg Arg Ile Asp Gin Ile Ser Arg Lys Asn 1605 1610 <210> <211> <212> <213> <220> <221> <222> <223> 57 930 DNA Corynebacterium glutamicum C DS (101)..(907) RXA02 691 <400> 57 cttagggctt atctgttttc eagccttgct ttttactagg egcteetgtc ccgcttcagt eaeeaaaaec aeacccctgg ttatgaccag atcggctaaa atg aac acc atg ect Met Asn Thr Met Pro gac caa ceg etc Asp Gin Pro Leu aac Asn eag gac gga tte Gin Asp Giy Phe acc gca tcc aaa Thr Aia Ser Lys ggg gtg Giy Val gaa ccc gac Giu Pro Asp aag cat eag Lys His Gin etc eec qac cgc Leu Pro Asp Arg gt t Val1 ctc gtg gac ggc Len Vai Asp Gly ctt aaa cca Leu Lys Pro acc acc cag Thr Thr Gin cag ett cgt gaa Gin Leu Arg Giu ttg gag gaa ate Leu Giu Glu Ile ctt cag Len Gin ect ggg gac atg Pro Gly Asp Met cet ggt gag cgc Pro Gly Giu Arg ctg gaa gaa aag Len Gin Giu Lys tat Tyr ggc gte agc cga Giy Val Ser Arg acg gtt egt egg Thr Val Arg Arg g eq Al a 80 att ggt gat etg Ile Gly Asp Len gt c Val gcg tec ggc agg Ala Ser Gly Arg ttg Leu aag ega get ego Lys Arg Ala Arg aaa ggt ace tte Lys Gly Thr Phe gtg gcc Val Ala 100 eac tcg ccg His Ser Pro atg gee gee Met Ala Ala 120 att tee ego etg Ile Ser Arg Len eat His 110 ttq gee teg ttt Len Ala Ser Phe tee gea gag Ser Ala Gin 115 agt tet tee Ser Ser Ser eag aag eta teg Gin Lys Len Ser aee age agg att Thr Ser Arg Ile ego ggt Arg Gly 135 eec gee cca gat gat att get gat tte Pro Ala Pro Asp Asp Ile Ala Asp Phe 140 ggt ace gat ege Gly Thr Asp Arg gee eag eae ate Ala Gin His Ile ttg ege ege etg Len Arg Arg Len cge Arg 160 ttt gga aat ggt Phe Gly Asn Gly cga Arg 165 ccc tat gcc att gac aac ggt tgg tac aac too gaa ttc gca cct gac 643 Pro Tyr Ala Ile Asp Asn Gly Trp Tyr Asn Ser Glu Phe Ala Pro Asp 170 175 180 ctg ctg gaa aat gat gtg tac aac tcc gtg tac tcc atc ctg gac cgc 691 Leu Leu Glu Asn Asp Val. Tyr Asn Ser Val Tyr Ser Ile Leu Asp Arg 185 190 195 gtc tat ggc gtc ccc gtc acc cag gcc gag caa acg gtc aco goc gta 739 Val Tyr Gly Val Pro Val Thr Gin Ala Glu Gin Thr Val Thr Ala Val 200 205 210 gca goc gac gaa gac acc gca cgg ctt ctg gac gtc acc ccc ggc gcc 787 Ala Ala Asp Glu Asp Thr Ala Arg Leu Leu Asp Val Thr Pro Gly Ala 215 220 225 cca ctc ctt cgt atc ctt cga cag tca ctt, tct ggc gat aag ccc gtg 835 Pro Leu Leu Arg Ile Leu Arg Gin Ser Leu Ser Gly Asp Lys Pro Val 230 235 240 245 qaa tgg tgc gtt toc ttq tac oga acc gac cga tat tot tta aaa aca 883 Glu Trp Cys Val Ser Leu Tyr Arg Thr Asp Arg Tyr Ser Leu Lys Thr 250 255 260 ttg gtt, aca cgc tcc gaa gat ctc tgacgtgaac ccattttggt ggc 930 Leu Val Thr Arg Ser Glu Asp Leu 265 <210> 58 <211> 269 <212> PRT (213> Corynebacterium glutamicum <400> 58 Met Asn Thr Met Pro Asp Gin Pro Leu Asn Gin Asp Gly Phe Pro Thr 1 5 10 Ala Ser Lys Gly Val Glu Pro Asp Asn Leu Pro Asp Arg Vai Leu Val 25 Asp Gly Leu Lys Pro Lys His Gin Gin Leu Arg Glu Ile Leu Glu Glu 40 Ile Cys Thr Thr Gin Leu Gin Pro Gly Asp Met Leu Pro Gly Giu Arg 55 Ile Leu Glu Glu Lys Tyr Gly Val Ser Arg Ile Thr Val Arg Arg Ala 70 75 Ile Gly Asp Leu Val Ala Ser Gly Arg Leu Lys Arg Ala Arg Gly Lys 90 Gly Thr Phe Val Ala His Ser Pro Leu Ile Ser Arg Leu His Leu Ala 100 105 110 Ser Phe Ser Ala Glu Met Ala Ala Gin Lys Leu Ser Ala Thr Ser Arg 115 120 125 Ile Leu Ser Ser Ser Arg Gly Pro Ala Pro Asp Asp Ile Ala Asp Phe 130 135 140 Phe 145 Phe Glu Ser Thr Val1 225 Gly Tyr Thr As n Ala Leu 195 Thr Pro Lys Leu Asp Gly Pro 180 Asp Ala Gly Pro Lys 260 Ala 150 Pro Leu Val1 Al a Pro 230 Glu Le u Gln Al a Glu Gl y 200 Asp Le u Cys Thr His Ile Asn 185 Val1 Glu Arg Val Arq 265 Thr 155 Asri ValI ValI Thr Le u 235 Leu Glu Leu Gly Tyr Thr Al a 220 Arg Tyr Asp Arg Tyr Se r 190 Ala Le u Ser Thr Arg 160 Ser Tyr Gln Asp Se r 240 Arg <210> 59 <z211> 1968 <212> DNA <213> Corynebacterium glutamicum <2 <221> CDS <222> (1945) <223> RXA00880 <400> 59 tccatqtqgt taaagatatg cctaaagatc tgaccaaaaa cacaagtaca gccaaattaa aggaaaggtt gaatttgacc acc Thr ga a Glu gg a Gly qcc Al a tca Ser cag Gl n tgc Cys ttg Le u gaa Glu 99C Gly gaa Glu ctg Leu t tc Phe ttt Phe gta Val1 act Thr gcc Ala aag Lys gac Asp ca g Gln cc t Pro ct a Leu gcc Al a 45 gtt Val1 ga c Asp gcc Al a gat Asp 30 aac As n ttt Phe cgt Arg tac Tyr att Ile gag Glu gt t Val1 ge~g Al a cgtqactaaa gacgtgacqa atg act tca cct aat Met Thr Ser Pro Asn 1 acc atc gga gaa tct Thr Ile Gly Glu Ser aag act cga cct tac Lys Thr Arg Pro Tyr tgg gtg aat gta act Trp Val Asn Val Thr gca aaa gga att att Ala Lys Gly Ile Ile ctg ctg tcc aat act Leu Leu Ser Asn Thr cgc tat gag tgg Arg Tyr Giu Trp gtg ett gat tte Val Leu Asp Phe gct Al a ate tgg gcc gct Ile Trp Ala Ala ggc gca cay Ala 100 gtg agc gtg Val Ser Val ate att gag Ile Ile Giu 120 ect Pro 105 ate tac agc tee Ile Tyr Ser Ser tca ctg tcc caa Ser Leu Ser Gin att gag tgg Ile Giu Trp 115 acc cct gat Thr Pro Asp gat tcc ggc gct Asp Ser Giy Ala ttg gee att acc Leu Ala Ile Thr gaa Giu 130 cat ace His Thr 135 gac ttg atg aag Asp Leu Met Lys aac Asn 140 ctg gtc ate ggt Leu Val Ile Gly gac gga act cca Asp Gly Thr Pro gcg Al a 150 att aag ggt tca Ile Lys Gly Ser tee aag ctg egc Ser Lys Leu Arg ege Arg 160 att eta gag ate Ile Leu Glu Ile tet teg geg tig Ser Ser Ala Leu gag Glu 170 ace ttg aag iii Thr Leu Lys Phe qgc ege gag ct Gly Arg Glu Leu ict gat Ser Asp 180 gag etg gig Glu Leu Val tct ttg gig Ser Leu Val 200 igg Trp 185 gaa cgc ait cat Glu Arg Ile His ace aag gee get Thr Lys Ala Ala gac ctg geg Asp Leu Ala 195 gge ige gag Gly Cys Glu tae ace tet gge Tyr Thr Ser Gly act ggt agg ccg Thr Gly Arg Pro aag Lys 210 ttg tee Leu Ser 215 eac tae eac tgg His Tyr His Trp t tg Le u 220 get. gag gtc ega Ala Glu Val Arg cig ate ace aat Leu Ile Thr Asn ga e Asp 230 ate gga geg ate Ile Gly Ala Ile atg eca ggt tea Met Pro Gly Ser itg cic ace tte Leu Leu ThrPhe ett Le u 245 cet t 9 geg cac Pro Leu Ala His ctt get ege gca Leu Ala Arg Ala gig Val 255 eac t 9 gee ttc His Leu Ala Phe get gte Ala Val 260 ace ggt qea Thr Giy Ala gaa cig eag Glu Leu Gin 280 ace Thr 265 eag tee cac tgg Gin Ser His Trp gat ttc age ace Asp Phe Ser Thr cit act ttg Leu Thr Leu 275 eca ege gig Pro Arg Val egt tee cge ceg Arg Ser Arg Pro eig att tig ggt Leu Ile Leu Gly gt Val 290 ttt gaa Phe Glu 295 aag gte ege aac Lys Val Arg Asn gee Ala 300 get get get aat Ala Ala Ala Asn get gac ggt ggc Ala Asp Gly Gly 1027 1075 gca Ala 310 ate aag ege ate Ile Lys Arg Ile ttt gag egi gee Phe Glu Arg Ala aag geg gee ati Lys Ala Ala Ile gaa Glu 325 tao tcc atg gct Tyr Ser Met Ala ott Leu 330 gat act gca gaa Asp Thr Ala Glu cca agc aag tco Pro Ser Lys Ser cag gtt Gin Val 340 1123 atg gca cat Met Ala His gct gtc ggt Ala Val Gly 360 aaa Lys 345 gog ttt gao aag Ala Phe Asp Lys ctg Le u 350 gtg tao too aag Val Tyr Ser Lys ato ogt gca Ile Arg Ala 355 toa gcg atg Ser Ala Met 1171 1219 ggo gat gtg oag Gly Asp Val Gin goc ato aco ggt Ala Ile Thr Gly ggt Gly 370 ggg oag Gly Gin 375 gag otg otg oao Gin Leu Leu His tto ogo ggt gtg Phe Arg Gly Val ggc Gly 385 atg aoo ato tao Met Thr Ile Tyr gaa Gin 390 ggt tat ggt otg Gly Tyr Gly Leu a og Thr 395 gaa tot gog got Giu Ser Ala Ala goa gcg gtg gao Al~a Ala Val Asp 1267 1315 1363 act gat oaa aag Thr Asp Gin Lys ggo act gtg ggt Gly Thr Val Gly aag Lys 415 oog atg ggt ggo Pro Met Gly Gly atg aoo Met Thr 420 ato aag ato Ile Lys Ile tto oag gga Phe Gin Gly 440 aat As n 425 gaa gat ggo gaa Glu Asp Gly Glu ato Ile 430 atg ota aaa ggo Met Leu Lys Gly gag atg ttg Glu Met Leu 435 goo oto oao Ala Leu His tat tgg aao aao Tyr Trp Asn Asn gaa gco aca goa Gin Ala Thr Ala gao ggt Asp Gly 455 tgg tto aao aoo Trp Phe Asn Thr gat ctg ggt gag Asp Leu Gly Giu otg Len 465 ttg gag tot gga Len Glu Ser Gly 1411 1459 1507 1555 1603 oao His 470 otg gtg ato ace Len Val Ile Thr gga Gly 475 ogt aag aaa gat Arg Lys Lys Asp atc gtg aoo gog Ile Val Thr Ala ggo aag aao gtt Gly Lys Asn Val oca gga 000 atg Pro Gly Pro Met gao ato ato ogo Asp Ile Ile Arg gea eac Ala His 500 coa ctg gtc Pro Leu Val ggo otg otg Gly Len Len 520 age Se r 505 cag qeo atg gtg Gin Ala Met Val gtg Val1 510 ggc gat ggt aaa Gly Asp Gly Lys oca tte gtt Pro Phe Val 515 tgg aag otg Trp Lys Len 1651 1699 gtg aoo ttg gat Val Thr Leu Asp ooa Pro 525 gat atg ttg aag Asp Met Len Lys ogg Arg 530 aao oac Asn His 535 aac att gog gaa Asn Ile Ala Gin ogo acg gtt tot Arg Thr Val Ser att got act gat Ile Ala Thr Asp 1747 1795 goa ctg ogt gog Ala Len Arg Ala gaa Gin 555 ato cag gat gca Ile Gin Asp Ala gte Val1 560 aac aao got aat Asn Asn Ala Asn gc Al a 565 acg qtg tct cat tca gag gcg atc aag Thr Val Ser Hius Ser Giu Ala Ile Lys 570 gac ctg acc gag gaa gcc gac gag ctg Asp Leu Thr Giu Giu Ala Asp Giu Leu 585 590 cgc aac gtt gtt gtt cgc cgt tac gca Arg Asn Val Val Val Arg Arg Tyr Ala 600 605 aac cga tgagtaacac agagacccaa ttt Asn Arg 615 <210> <211> 615 (212> PRT <213> Corynebacterium giutamicum <400> Met Thr Ser Pro Asn Thr Leu Gin Giu cgg ttc tac atc ctt gat cgc Arg Phe Tyr Ile Leu Asp Arg 575 580 acc cca acg ctg eag gtc aag Thr Pro Thr Leu Lys Val Lys 595 gac gcc ato gac cac atc tac Asp Ala Ile Asp His Ile Tyr 610 1843 1891 1939 1968 1 Thr Lys Trp Ala Leu T rp Ser Thr Glu 145 Ile Arg Ala Gly Arg As n Gly Ser Ala Ile 115 Thr Gly Giu Leu Asp 195 Ser Tyr Thr Ile Th r Ala Asp Pro As n 165 Asp Ala Cys Le u 40 Giu Giy Giu Val1 Glu 120 Asp Lys Ala ValI ValI 200 Le u Phe Ph e Val1 Trp Pro 105 Asp Le u Gi y Le u Trp 185 T yr Thr Ala Lys Asp Gin 75 Val Tyr Gly Lys Pro 155 Thr Arg Ser Giu Leu Pro Giu Gly Le u Se r Al a As n 140 Ser Leu Ile Gly Pro Leu Ala Val1 Asp Asp Ser Val 125 Leu Lys Lys His Thr 205 Tyr Ile Giu Val1 Al a Ile Leu Ile Gi y Arg 160 Gly Lys Arg Pro Ala 225 Leu Leu Se r Gly Ala 305 Lys Ser Ser Gly Gly 385 Ala Met Lys Al a Leu 465 Ile Ile Gly Lys 210 Le u Le u Ala Thr Val1 290 Al a Al a Lys Lys Gly 370 Met Ala Gly Gi y Glu 450 Le u Val2 Ile Lys Gly Ile Thr Phe Leu 275 Pro Asp Ala Ser Ile 355 Ser Thr Val Gly Glu 435 Al a Glu Thr Arg Pro 515 Cys Thr Phe Al a 260 Thr Arg Gly Ile Gin 340 Arg Al a Ile Asp Met 420 Met Le u Ser Al a Al a 500 Phe Giu As n Le u 245 Val1 Le u Val1 Gly Giu 325 Val1 Ala Met Tyr Phe 405 Thr Leu His Gly Gly 485 His Val1 Leu Asp 230 Pro Thr Glu Phe Al a 310 Tyr Met Al a Gly Glu 390 Th r Ile Phe Asp His 470 Gly Pro Gly Ser 215 Ile Leu Gly Le u Glu 295 Ile Se r Ala Val Gin 375 Gly Asp Lys Gin Gi y 455 Leu Lys Le u Leu His Gly Al a Al a Gin 280 Lys Lys Met His Gly 360 Glu Tyr Gin Ile Gly 440 Trp Val1 Asn Val Leu 520 Tyr Ala His Thr 265 Arq Val1 Arq Ala Lys 345 Gly Le u Gly Lys Asn 425 Tyr Phe Ile Val1 Ser 505 Val1 Trp Al a 235 Leu Ser A rqc As n Met 315 Asp Phe Val1 His Thr 395 Gly Asp Asn Thr Gly 475 Pro Al a Le u Leu 220 Met Al a His Pro Al a 300 Phe Thr Asp Gin Phe 380 Glu Thr Gly Asn Gly 460 Arg Gly Met Asp Ala Pro Arg Trp As n 285 Ala Gin Ala Lys Tyr 365 Phe Ser Val1 Giu Pro 445 Asp Lys Pro Val1 Pro 525 Gin Gly Al a Se r 270 Le u Al a Arg Glu Leu 350 Ala Arg Ala Gly Ile 430 Gin Leu Lys Met ValI 510 Asp Arg Arg 240 His Phe Le u As n Gin 320 Pro Tyr Thr Val Al a 400 Pro Le u Thr Gin Len 480 Asp Asp Le u Lys Arg Trp Lys Leu Asn His Asn Ile Ala Glu 530 535 Glu Ile Ala Thr Asp Pro Ala Leu Arg Ala Glu 545 550 555 Asn Asn Ala Asn Ala Thr Val Ser His Ser Glu 565 570 Tyr Ile Leu Asp Arg Asp Leu Thr Glu Glu Ala 580 585 Thr Leu Lys Val Lys Arg Asn Val Val Val Arg 595 600 Ile Asp His Ile Tyr Asn Arg 610 615 <210> 61 (211> 1047 <212> DNA <213> Corynebacterium giutamicum <220> (221> CDS <222> (1024) (223> RXA01060 (400> 61 ttccatttac acatctgttc gactcgcgcc cgaatgatgt cttccatact tttactgatt gataagaatg gacaaagaca Arg Gin Ile Glu Tyr 605 Thr Asp Lys Leu 590 Ala Se r Val1 560 Phe Pro Ala cgcatcaaca tgagaagcta cga Arg tgg Trp ttc Phe aaa Lys gat Asp agq Arg tct aca Thr ttC Ph e t ca Ser cgt Arg cta Leu gaa Glu gcg ggC Gly act Thr gaa Glu ctt Le u gaa Glu tgg Trp aga tgg Trp gat Asp tcC Ser cac His gca Al a gag Glu att gct Ala ga c Asp t cC Ser gcg Ala 60 agg Arg gaa Glu gag gcC Al a acc Thr ctc Le u atg Met cac His tta Leu agc gta Val ga t Asp gtt Val1 gag Glu gt a Val gca Al a aca att Ile 15 tat Tyr cca Pro caa Gin ct a Leu tgg Trp 95 aaa atg Met 1 gaa Glu cct Pro gct Al a ga c Asp ttc Phe t CC Ser tct ga t Asp tat Tyr ctg Leu ct c Leu aaa L ys gag Giu ctt aac cgc aca ctc Asn Arg Thr Leu gag Glu aat Asn ct g Le u gtg Val1 cac His acc Thr 100 gat Ser Ala Val Arg Ile Ile Giu Ser Thr Lys Glu Ser Leu Ala Asp Gin 105 tac aaa tac gca Tyr Lys Tyr Ala 110 ttg cct gag ota Leu Pro Glu Leu 115 ttc cag gaa Phe Gin Giu tao aga gat Tyr Arg Asp 120 att Ile 130 tca cgc Ser Arg 135 ggg atc ttt gao Gly Ile Phe Asp ttt Phe 140 gag ctg gag gga Glu Leu Giu Gly acc ctc aaa gta Thr Leu Lys Val caa agc acg ctt Gin Ser Thr Leu att cct tgg gac Ile Pro Trp Asp atc goc aat ggt Ile Ala Asn Gly gtc cct gca agt Val Pro Ala Ser ct t Leu 170 cqq aat ttt gga Arg Asn Phe Gly tta atg gac ogt Leu Met Asp Arg gac acc Asp Thr 180 gga gat ott Gly Asp Leu gag atc cat Giu Ile His 200 gca gat ccc att Ala Asp Pro Ile aga cot oqa gaa Arg Pro Arg Glu ctc aaa ttt Leu Lys Phe 195 cgg gaa act Arg Giu Thr aat tgt cca gat Asn Cys Pro Asp aat cct tgg ata Asn Pro Trp Ile atg Met 210 ttt gat Phe Asp 215 ttc atg atg gaa Phe Met Met Giu atc Ile 220 goa act gaa. aca Ala Thr Glu Thr tgg ttC cat got Trp Phe His Ala aac 000 goa tat Asn Pro Ala Tyr too gto tao aco Ser Val Tyr Thr tac Tyr 240 gat ott att tot Asp Leu Ile Ser atg oca gat ttc Met Pro Asp Phe ott Leu 250 gtt gaa ggg agc Val Giu Gly Ser ttt Phe 255 ogt cog cat toa Arg Pro His Ser gtg aaa Val Lys 260 oga tot tgg Arg Ser Trp gca tot oao Ala Ser His 280 aaa att oaa aag Lys Ilie Gin Lys got aaa got gtt Ala Lys Ala Val gag tot tat Glu Ser Tyr 275 tac agg gca Tyr Arg Ala 931 979 gat tao tgo atg Asp Tyr Cys Met aog otg aca cat Thr Leu Thr His gao Asp 290 ato gag Ile Giu 295 tta too otg acg Leu Ser Leu Thr cot Pro 300 aca aaa act gag Thr Lys Thr Glu oca ago aoa Pro Ser Thr 1024 taagaaaaoo tcgoctgooo act <210> 62 <211> 308 <212> PRT <213> Corynebacterium glutamicum <400> 62 Met Asn Arg Thr Leu Arg Thr Leu Gly Trp 1047 Leu Ala Ala Val Ile Gin 1 5 10 Glu Asp Pro Glu Pro Trp Phe Thr Thr Asp Pro Asp Thr Asp Tyr Val 25 Pro Tyr Val Asn Ser Phe Ser Phe Glu Ser Leu Ser Leu Val Pro Asp 40 Ala Leu Met Leu Leu Lys Arg Ser Leu His Leu Ala Met Glu Gin Gin 55 Asp Leu Pro Val Lys Asp Leu Gin Glu Ala Leu Arg His Val Leu Val 70 75 Phe Lys Phe His Phe Arg Glu Glu Trp Glu Leu Glu Leu Ala Trp Asp 90 Ser Glu Arg Thr Lys Ser Ala Val Arg Ile Ile Glu Ser Thr Lys Glu 100 105 110 Ser Leu Ala Asp Gin Tyr Arg Asp Tyr Lys Tyr Ala Phe Leu Pro Glu 115 120 125 Leu Ile Phe Gin Glu Ser Arg Gly Ile Phe Asp Phe Glu Leu Glu Gly 130 135 140 Tyr Thr Leu Lys Val Gly Gin Ser Thr Leu Ser Ile Pro Trp Asp Met 145 150 155 160 Ile Ala Asn Gly Tyr Val Pro Ala Ser Leu Arg Asn Phe Gly Glu Leu 165' 170 175 Met Asp Arg Asp Thr Gly Asp Leu Asp Ala Asp Pro Ile Leu Arg Pro 180 185 190 Arg Glu Leu Lys Phe Glu Ile His Asn Cys Pro Asp Leu Asn Pro Trp 195 200 205 Ile Met Arg Glu Thr Phe Asp Phe Met Met Glu Ile Ala Thr Glu Thr 210 215 220 Gly Trp Phe His Ala Leu Asn Pro Ala Tyr Asn Ser Val Tyr Thr Tyr 225 230 235 240 Asp Leu Ile Ser Arg Met Pro Asp Phe Leu Val Glu Gly Ser Phe Arg 245 250 255 Pro His Ser Val Lys Arg Ser Trp Glu Lys Ile Gin Lys Ile Ala Lys 260 265 270 Ala Val Glu Ser Tyr Ala Ser His Asp Tyr Cys Met Ser Thr Leu Thr 275 280 285 His Asp Tyr Arg Ala Ile Glu Leu Ser Leu Thr Pro Thr Lys Thr Glu 290 295 300 Glu Pro Ser Thr 305 <210> 63 (211> <212> <213> <220> <221> <222> <223> 1848 DNA Corynebacterium giutamicum C Os (101)..(1825) RX N01722 <400> 63 ctcattcccc tcgctaaaag ctgcataaag tttcgacgtt ctgtcgttgc gtgtcgcatg ccccggctat tgttgattgc ttcaaagttg attgcttgca atg ctc agc acg Met Leu Ser Thr 1 atg Met cag gac gtc cca Gin Asp Val Pro ctg Leu tca tta acc aqa Ser Leu Thr Arg ctc gag tac ggg Leu Glu Tyr Gly tcc act Ser Thr gtt cac ggt Val His Gly gaa caa gca Giu Gin Ala act ttg atc acc Thr Leu Ile Thr acg Thr tgg ggc "ggt gcc Trp Gly Gly Ala gat ggc att Asp Giy Ile gct gcg gct Ala Ala Ala cag caa act ttt Gin Gin Thr Phe gct gtg ggg qct Ala Val Gly Ala ttg gct Leu Ala cat gcg ctg cat His Ala Leu His tct tta qgt att Ser Leu Gly Ile act Th r qgg gat cag cga Gly Asp Gin Arg gtg Val gcg tcg atg ctc Ala Ser Met Leu aac tgc gcg gaa Asn Cys Ala Giu cac His 80 atg gaa act atg Met Glu Thr Met ttt Phe gca gtc gca tgc Ala Val Ala Cys atg Met ggt gcc gtg ttt Gly Ala Val Phe ccg ctg aac aag Pro Leu Asn Lys cag ttq Gin Leu 100 atg aat gat Met Asn Asp gtt atc gct Val Ile Ala 120 Ile Val Phe Ile ctc Leu 110 cac tct gaa His Ser Glu gct gaa gtg Ala Glu Val 115 atc tta aaa Ile Leu Lys gat ccg cgc atg Asp Pro Arg Met gaa caa ttg ggt Giu Gin Leu Gly gaa aca Glu Thr 135 cca aaa gtt cgt Pro Lys Vai Arg gtg gtg ttt att Val Val Phe Ile gga Giy 145 ccg aat gat ttc Pro Asn Asp Phe agc gcq gcg gcc Ser Ala Ala Ala atg ccg gag gga Met Pro Giu Gly atg Met 160 aag ctg tat tcc Lys Leu Tyr Ser tat T yr 165 gaa gcg ctc ctt Giu Ala Leu Leu gac Asp 170 ggc cgt tcc act Gly Arg Ser Thr tac sac tgg ccc Tyr Asn Trp Pro gag cag Giu Gin 180 gat gaa cgc act gct qct gca att tgc tat tcc acc gqt aca tcg gga Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser Thr Gly Thr Ser Gly 185 ggt qtg gtg tat Gly Val Val Tyr 190 cac cgc tcg ctt His Arg Ser Leu 195 tta cag tcg Leu Gin Ser ccg ccg aag Pro Pro Lys 200 739 ttg agc Leu Ser 215 ttg cgc acc acg Leu Arg Thr Thr tcc ctc gca gtg Ser Leu Ala Val cac ggc gaa acg His Gly Giu Thr ctg tgc tgt gtg Leu Cys Cys Val ccg Pro 235 att tac cac gtc Ile Tyr His Val ct C Le u 240 agc tgg ggc gtg Ser Trp Gly Val ccg Pro 245 atc gca gcg ttt Ile Ala Ala Phe tcc ggc act ccc Ser Gly Thr Pro gtg ctt cct gga Val Leu Pro Gly ccg gat Pro Asp 260 ctt tct gcg Leu Ser Ala gtg gcg cat Val Ala His 280 aca ttg gca aag Thr Leu Ala Lys at c Ile 270 att tcc acc acg Ile Ser Thr Thr ctg cct cgc Leu Pro Arq 275 gtt cac tac Val His Tyr ggc gtg cct act Gly Val Pro Thr tgg att. cag ctg Trp Ile Gin Leu ctg aa Leu Lys 295 sat ccc cca gag Asn Pro Pro Giu cgt Arg 300 atg tct ctg cgt Met Ser Leu Arg gag G iu 305 cta tac gtg ggc Leu Tyr Val Gly ggt Giy 310 tct gcg gtg cct Ser Ala Val Pro cca Pro 315 atc gtg atc. acc Ile Vai Ile Thr atg Met 320 tgg gag cag cgc Trp Giu Gin Arq tat Tyr 325 ggc gtg gat gtt Gly Val Asp Vai cac gtg tgg ggt His Val Trp Giy acg gas acc tcc Thr Giu Thr Ser acc gtg Thr Val 340 1027 10,75 1123 1171 1219 ggt act gtg Gly Thr Val aat tat cga Asn Tyr Arg 360 cqc cca oca tca Arg Pro Pro Ser ggt Gly 350 qtt tct ggt gas Val Ser Gly Giu agc cgg tgg Ser Arg Trp 355 cag tac cgc Gin Tyr Arg gtc tcc cag ggc Val Ser Gin Gly ttc ccc gcc tcc Phe Pro Ala Ser att gtc Ile Val 375 sac gac ggc cag Asn Asp Giy Gin gtc Val 380 atg gcg tcc acc Met Ala Ser Thr gac Asp 385 cgc aac gag ggc Arg Asn Glu Gly att cag gtc cgc Ile Gin Vai Arg ccg tgg gtg act Pro Trp Vai Thr agt. tac ttc cac Ser Tyr Phe His ccc Pro 405 1267 1315 1363 gat gtg gsa aaa Asp Val Glu Lys ggt ggc acc gcc Giy Giy Thr Ala t ca Ser 415 aca ttc cgc gac Thr Phe Arg Asp cat gac His Asp 420 gtt gaa gag gas sac gat gag ctc ttc acc gcc gac ggc tgg ctg cgc Val Giu Glu Giu Asn Asp Glu Leu Phe Thr Aia Asp Gly Trp Leu Arg 1411 ace Thr gac Asp get Ala 470 gcc Ala gtc Val1 cgc Arg gaa Giu tat Tyr 550 ggg Gly cgc Arg 455 ca g Gin gtc Val ace Thr ct C Le u tat Tyr 535 ga c Asp gac Asp 440 gee Ala etg Leu att Ile atg Met cgc Arg 520 tgg Trp aag Lys gga Gi y ga t Asp aac As n tte Phe 490 tac T yr caa Gin ttt Phe gac Asp tct Ser gte Val1 etc Leu 475 ccc Pro ccc Pro ctt Le u gt t Val1 etc Leu 555 ac Thr 445 cgt Ar g gtg Vali gac Asp att Ile gae Asp 525 gag Giu aac As n gat gga Asp Gly gge gge Giy Gly acg gaa Thr Giu 480 tgg gtg Trp Vai 495 cge acc Arg Thr eta ccc Leu Pro gat aaa Asp Lys etg cgc Leu Arg 560 ace Thr att. Ile gte Vali ccc Pro ca a Gin tee Ser tge Cys 485 geca Ala gag Giu eca Pro aaa Lys ga a Glu egg gaa Arg Giu aae tgg Asn Trp 530 ace tee Thr Ser 545 aae gge Asn Gly 1459 1507 1555 1603 1651 1699 1747 1795 1845 ace gee Thr Ala 515 atg etg Met Leu gte ggt Vai Giy gat tte Asp Phe gta att aag ctt aaa ggg eea ggt Val Ile Lys Leu Lys Gly Pro Giy 570 get <210> 64 <211> 575 <212> PRT <213> Corynebacterium giutamicum <400> 64 Met Leu Ser Thr Met Gin Asp Vai I 1 5 Giu Tyr Giy Ser Thr Val His Giy Giy Ala Asp Gly Ile Giu Gin Ala 40 Aia Arg Aia Aia Ala Leu Ala His Thr Gly Asp Gin Arg Vai Ala Ser gaa aaa 3lu Lys 575 taaettccct atttatteeg 1848 Leu 10 Thr Gin Leu Leu Thr Thr Ser Ser Cys Arg Thr Al a Le u Ala Ile T rp ValI Giy Giu Met Glu Thr Met Phe Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro 90 Leu Asn Lys Gin Leu Met Asn Asp Gin Ile Val Phe Ile Leu Asn His 100 105 110 Ser Glu Ala Glu Val Val Ile Ala Asp Pro Arg Met Ala Glu Gin Leu 115 120 125 Gly Glu Ile Leu Lys Glu Thr Pro Lys Val Arg Ala Val Val Phe Ile 130 135 140 Gly Pro Asn Asp Phe Ser Ser Ala Ala Ala His Met Pro Glu Gly Met 145 150 155 160 Lys Leu Tyr Ser Tyr Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr 165 170 175 Asn Trp Pro Glu Gin Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser 180 185 190 Thr Gly Thr Ser Gly Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser 195 200 205 Leu Tyr Leu Gin Ser Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val 210 215 220 Glu His Gly Glu Thr Phe Leu Cys Cys Val Pro Ile Tyr His Val Leu 225 230 235 240 Ser Trp Gly Val Pro Ile Ala Ala Phe Met Ser Gly Thr Pro Leu Val 245 250 255 Leu Pro Gly Pro Asp Leu Ser Ala Pro Thr Leu Ala Lys Ile Ile Ser 260 265 270 Thr Thr Leu Pro Arg Val Ala His Gly Val Pro Thr Leu Trp Ile Gin 275 280 285 Leu Met Val His Tyr Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg 290 295 300 Glu Leu Tyr Val Gly Gly Ser Ala Val Pro Pro Ile Val Ile Thr Met 305 310 315 320 Trp Glu Gin Arg Tyr Gly Val Asp Val Val His Val Trp Gly Met Thr 325 330 335 Glu Thr Ser Thr Val Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser 340 345 350 Gly Glu Ser Arg Trp Asn Tyr Arg Val Ser Gin Gly Arg Phe Pro Ala 355 360 365 Ser Leu Gin Tyr Arg Ile Val Asn Asp Gly Gin Val Met Ala Ser Thr 370 375 380 Asp Arg Asn Glu Gly Glu Ile Gin Val Arg Gly Pro Trp Val Thr Ala 385 390 395 400 Ser Tyr Phe His Pro Asp Val Giu Lys Giu Gly Phe Asp Phe Glu 465 Glu Giu Ar g Asn Thr 545 As n Asp Trp 435 Thr Ile Val1 Pro Thr 515 Met Val1 Asp 405 As p Arg Gin Ser Cys 485 Ala Glu Pro Lys Giu 565 Giu Gly Arg 455 Gin Val1 Thr Leu Tyr 535 Asp Ile 410 As n Gly Asp Asn Phe 490 Tyr Gin Phe Asp Lys 570 Giy Giu Vali Ile 460 Ile Asp Gly Ar g Asp 540 Arg Pro Thr Le u Thr 445 Arg Val1 Asp Ile Asp 525 Giu Asn Gly Ser 415 Thr Asp Gly Thr T rp 495 Arg Leu Asp Leu Lys 575 Thr Al a Gly Gly Giu 480 Val1 Thr Pro Lys Arg 560 <210> <211> 1848 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1825) <223> FRXA01722 <400> ctcattcccc tcgctaaaag ctqcataaag tttcqacgtt ctgtcgttgc gtgtcgcatg ccccggctat tgttgattgc cag qac gtc cca ctg tca tta acc Gin Asp Val Pro Leu Ser Leu Thr gtt cac ggt qat act ttg atc acc Val His Gly Asp Thr Leu Ile Thr gaa caa gca cag caa act ttt agt Glu Gin Ala Gin Gin Thr Phe Ser aga Arg a og Thr 30 gct Ala ct C Leu ggc Gly ggg Gi y ttcaaagttq attgcttgca atg ctc agc acg atg Met Leu Ser Thr Met 1 gag tac ggg tcc act Giu Tyr Gly Ser Thr ggt gcc gat ggc att Gly Ala Asp Gly Ile got aga gct gcg gct Ala Arg Ala Ala Ala ttq qct Leu Ala cat gcg ctg cat His Ala Leu His tct tta ggt att Ser Leu Gly Ilie ggg gat cag cga Gly Asp Gin Arg gtg Val1 gcg tcg atg ctc Ala Ser Met Leu aac tgc gcg gaa Asn Cys Ala Giu cac: His 80 atg gaa act atg Met Giu Thr Met ttt Phe gca gtc gca tgc Ala Val Ala Gys atg Met ggt gcc gtg ttt. Gly Ala Val Phe ccg ctg aac aag Pro Leu Asn Lys cag ttg Gin Leu 100 atq aat gat Met Asn Asp gtt atc gct Val Ile Ala 120 att gtg ttc att Ile Val Phe Ile ctc Le u 110 aat cac tct gaa Asn His Ser Giu gct gaa gtg Ala Giu Vai 115 atc tta aaa Ile Leu Lys gat ccg cgc atg Asp Pro Arg Met gaa caa ttg ggt Giu Gin Leu Gly gag Giu 130 gaa aca Giu Thr 135 cca aaa gtt cgt Pro Lys Val Arg gtg gtg ttt att Val Val Phe Ile ccg aat gat ttc Pro Asn Asp Phe tct Se r 150 agc gcg gcg gcc Ser Ala Ala Ala atg ccg gag gga Met Pro Giu Giy atg Met 160 aag ctg tat tcc Lys Leu Tyr Ser gaa gcg ctc ctt, Glu Ala Leu Leu gac Asp 170 ggc cgt tcc act Gly Arg Ser Thr tac aac tgg ccc Tyr Asn Trp Pro gag cag Glu Gin 180 gat gaa cgc Asp Glu Arg ccg ccg aag Pro Pro Lys 200 gct gct gca att Ala Ala Ala Ile tgc Cys 190 tat tcc acc ggt Tyr Ser Thr GJly aca tcg gga Thr Ser Gly 195 tta cag tcg Leu Gin Ser ggt gtg gtg tat Gly Val Val Tyr tcc Ser 205 cac cgc tcg ctt His Arg Ser Leu tat T yr 210 ttg agc Leu Ser 215 ttg cgc acc acg Leu Arg Thr Thr tcc ctc gca gtg Ser Leu Ala Val cac ggc gaa acg His Gly Giu Thr ttc Phe 230 ctg tgc tgt gtg Leu Cys Cys Val att tac cac gtc Ile Tyr His Val ctc Leu 240 agc tgg ggc gtg Ser Trp Giy Vai ccg Pro 245 atc gca gcg ttt Ile Ala Ala Phe at g Met 250 tcc ggc act ccc Ser Giy Thr Pro ctg Leu 255 gtg ctt cct gga Val Leu Pro Gly ccg gat Pro Asp 260 ctt tct gcg Leu Ser Ala gtq gcg cat Val Ala His 280 ccg Pro 265 aca ttg gca aag Thr Leu Ala Lys atc Ile 270 att tcc acc acg Ile Ser Thr Thr ctg cct cgc Leu Pro Arg 275 gtt cac tac Val His Tyr 931 979 ggc qtq cct act Gly Val Pro Thr ct c Le u 285 tgg att cag ctg Trp Ile Gin Leu ctg aaa Leu Lys 295 aat ccc cca gag Asn Pro Pro Giu cgt Arg 300 atg tct Ctg cgt Met Ser Leu Arg cta tac gtg ggc Leu Tyr Val Gly tet geg gtg eet Ser Ala Vai Pro ate gtg atc ace Ile Val Ile Thr tgg gag cag cgc Trp Giu Gin Arg tat Tyr 325 1027 1075 1123 1171 ggc gtg gat gtt Gly Val Asp Val gte Val1 330 cac gtg tgg ggt His Val Trp Gly atg Met 335 acg gaa acc tcc Thr Glu Thr Ser acc gtg Thr Val 340 ggt act gtg Gly Thr Val aat tat cga Asn Tyr Arg 360 cgc cca eca tea Arg Pro Pro Ser gtt tet ggt gaa agc cgg tgg Val Ser Gly Giu Ser Arg Trp 355 gtc tcc cag ggc Val Ser Gin Gly cga Arg 365 ttc ccc gee tcc Phe Pro Ala Ser ct g Leu 370 cag tac cge Gin Tyr Arg 1219 att gtc Ile Val 375 aac gae ggc cag Asn Asp Giy Gin atg geg tcc ace Met Ala Ser Thr cgc aac gag gge Arg Asn Glu Gly 1267 1315 gag Giu 390 att eag gtc cge Ile Gin Vai Arg ceg tgg gtg act Pro Trp Vai Thr gca Ala 400 agt tac ttc cac Ser Tyr Phe His ccc Pro 405 gat gtg gaa aaa gaa ggt ggc ace gcc tea aca ttc cgc gac cat gac Asp Val Giu Lys Glu Gly Gly Thr Ala Ser Thr Phe Arg Asp His Asp 410 415 420 gtt gaa gag Val Glu Glu ace ggg gac Thr Gly Asp 440 aae gat gag etc Asn Asp Glu Leu. ace gee qac gge Thr Ala Asp Giy tgg ctg ege Trp Leu Arg 435 ace ate caa. Thr Ile Gin 1363 1411 1459 gtt gga tet gte Val Gly Ser Val age gat gga ttc Ser Asp Giy Phe etc Leu 450 gac ege Asp Arg 455 gee ege gat gte Ala Arg Asp Vai ate Ile 460 egt tet gge ggc Arg Ser Giy Giy tgg att tae tce Trp Ile Tyr Ser cag ctg gaa aae Gin Leu Glu Asn ate gtg get acs Ile Val Ala Xaa gag gtt gte gaa Giu Val Vai Glu tgc Cys 485 1507 1555 1603 gee gte att gge Ala Val Ile Gly ttc Phe 490 eec gat gac aag Pro Asp Asp Lys t gg Trp 495 gtg gaa cgt ccc Val Giu Arg Pro etc gca Leu Ala 500 gte ace atg Val Thr Met cgc etc ege Arg Leu Arg 520 tac ccc ggc att Tyr Pro Gly Ile ege aec egg gaa Arg Thr Arg Giu ace gee gag Thr Ala Giu 515 atg ctg eca Met Leu Pro 1651 1699 gat caa ctt ege Asp Gin Leu Arg ege eta ccc aac Arg Leu Pro Asn gaa tat tgg aca ttt gtt gat gag qtg gat aaa acc tcc qtc ggt aaa 1747 Giu Tyr Trp Thr Phe Val Asp Giu Val Asp Lys Thr Ser Val Giy Lys 535 540 545 tat gac aag aag gac ctc cgc aac cac ctg cgc aac ggc gat ttc gaa 1795 Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg Asn Gly Asp Phe Giu 550 555 560 565 gta att aag ctt aaa ggg cca ggt gar aaa taacttccct atttattccg 1845 Val Ile Lys Leu Lys Giy Pro Giy Xaa Lys 570 575 gct 1848 <210> 66 <211> 575 <212> PRT <213> Corynebacterium giutamicum <400> 66 Met Leu Ser Thr Met Gin Asp Val Pro Leu Ser Leu Thr Arg Ile Leu 1 5 10 Giu Tyr Gly Ser Thr Vai His Giy Asp Thr Leu Ile Thr Thr Trp Giy 25 Giy Ala Asp Gly Ile Giu Gin Ala Gin Gin Thr Phe Ser Ala Val Gly 40 Ala Arg Ala Ala Ala Leu Ala His Ala Leu His Asp Ser Leu Giy Ile 55 Thr Gly Asp Gin Arg Val Ala Ser Met Leu Tyr Asn Cys Ala Giu His 70 75 Met Giu Thr Met Phe Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro 90 Leu Asn Lys Gin Leu Met Asn Asp Gin Ile Val Phe Ile Leu Asn His 100 105 110 Ser Giu Ala Giu Vai Vai Ile Ala Asp Pro Arg Met Ala Giu Gin Leu 115 120 125 Gly Giu Ile Leu Lys Glu Thr Pro Lys Vai Arg Ala Val Val Phe Ile 130 135 140 Giy Pro Asn Asp Phe Ser Ser Ala Ala Ala His Met Pro Giu Gly Met 145 150 155 160 Lys Leu Tyr Ser Tyr Giu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr 165 170 175 Asn Trp Pro Giu Gin Asp Giu Arg Thr Ala Ala Ala Ile Cys Tyr Ser 180 185 190 Thr Gly Thr Ser Gly Pro Pro Lys Giy Val Val Tyr Ser His Arg Ser 195 200 205 Leu Tyr Leu Gin Ser Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val Glu 225 Ser Le u Thr Leu Gi u 305 Trp Glu Gly Ser Asp 385 Ser Phe Asp Phe Glu 465 Giu Glu Arg Asn 210 His Trp Pro Thr Met 290 Le u Gi u Thr Gi u Le u 370 Arg Tyr Arg Gly Le u 450 T rp Val1 Arg Giu Trp 530 Gly Gly Gly Le u 275 Val1 Tyr Gin Ser Ser 355 Gin As n Phe Asp T rp 435 Thr Ile Val1 Pro Thr 515 Met Thr Pro 245 Asp Arg Tyr Giy Tyr 325 Val1 Trp Arg Gly Pro 405 Asp Arg Gin Ser Gys 485 Al a Giu Pro 215 Leu Ala Ser Ala Lys 295 Ser Val T hr Tyr Val 375 Ile Val1 Giu Gly Arg 455 Gln Val1 Thr Le u Tyr 535 Cys Al a Ala His 280 As n Al a Asp Val1 Arg 360 As n Gin Glu Gin Asp 440 Al a Leu Ile Met Arq 520 Trp Pro 235 Ser Leu Pro Glu Pro 315 His Pro Gin Gin Gly 395 Gi y Asp Ser Vali Leu 475 Pro Pro Le u Val 220 Ile Gly Ala Thr Arg 300 Ile Val Pro Giy Val1 380 Pro Gly Gin Val1 Ile 460 Ile Asp Gly Arg As p 540 T yr Thr Lys Len 285 Met Val Trp Ser Arg 365 Met Trp, Thr Len Th r 445 Arg Val1 Asp Ile Asp 525 Gin His Pro Ile 270 Trp Ser Ile Gly Gly 350 Phe Al a Val1 Al a Phe 430 Ser Ser Al a Lys Giu 510 Arq Val1 Val Len 255 Ile Ile Leu Thr Met 335 Val1 Pro Ser Thr Se r 415 Thr Asp Gly Xaa Trp 495 Arg Len Asp Len 240 Val1 Ser Gin Arg Met 320 Thr Se r Ala Thr Ala 400 Thr Al a Gly Gly Gin 480 Val1 Th r Pro Lys Thr Ser Val Gly Lys Tyr Asp Lys Ly's Asp Leu Arg Asn His Leu Arg 545 550 555 560 Asn Gly Asp Phe Glu Val Ile Lys Leu Lys Gly Pro Gly Xaa Lys 565 570 575 <210> 67 <211> 14 <212> DN <213> Co <220> <221> CD <222> (1 <223> RX. 01 A rynebacterium S 01)..(1378) A01644 glutamicum <400> 67 gtaggtagag gcttgtggtc actacttgtg gccaoatttt aaaaaaatgc acaagaagag aaagcaaagc attatgagta acgccgtagc gcaggacctc atg acc atc goc gac Met Thr Ile Ala Asp ato gtc gag gc Ile Val Glu Ala acc act gca ccc Thr Thr Ala Pro cca ttc cac atc Pro Phe His Ile act gcc Thr Ala ttc gat gga Phe Asp Gly gtt gcc aac Val Ala Asn ttc act qgc oct Phe Thr Gly Pro gaa Glu gat gct ccc tac Asp Ala Pro Tyr cag otg ttt Gin Leu Phe. oca gqa gat Pro Gly Asp acg gat gca gta Thr Asp Ala Val tac atc gca aca Tyr Ile Ala Thr ttg ggt Leu Gly ttg gca cgt gc Leu Ala Arg Ala ctc atg gqa gac Leu Met Gly Asp atc gtg qaa ggt Ile Val Giu Gly 211 259 307 355 403 gag Glu cat ccc ggc cat His Pro Gly His cct Pro 75 tat ggq atc ttt Tyr Gly Ile Phe ga t Asp gcg ttg aag gag Ala Leu Lys Glu tac cgc tgc ttc Tyr Arg Cys Phe cgc cca gat gca Arg Pro Asp Ala acc acc ttg cag Thr Thr Leu Gin ato atg Ile Met 100 tgg act ctg Trp Thr Leu atg gaa caa Met Giu Gin 120 aaa atg aat gcc Lys Met Asn Ala tta Le u 110 aaa ttc cag gaa Lys Phe Gin Glu att cca cca Ile Pro Pro 115 ggg cta gca Gly Leu Ala gcc cot gca Ala Pro Ala tgg ogt Trp Arg 125 cgc gao Arg Asp 140 aaa gca ctg ato Lys Ala Leu Ile too agg Ser Arg 135 cac tog aaa too His Ser Lys Ser aag aaa gc Lys Lys Ala ago tao cac tao Ser Tyr His Tyr ga c Asp 150 gtg ggc aat gag Val Gly Asn Giu ttc Phe 155 taG tee ctg ttt Tyr Ser Leu Phe tta Leu 160 gat gat tcc atg Asp Asp Ser Met tat acc tgc gcg Tyr Thr Cys Ala tat eca acg cca Tyr Pro Thr Pro tca agt ttg gaa Ser Ser Leu Giu gaa gc Giu Ala 180 caa gaa aac Gin Glu Asn ggc gat cgc Gly Asp Arq 200 tac cgc etc atc Tyr Arg Leu Ile ttt Phie 1 90, gaa aaa ctg cgt Giu Lys Leu Arg ctg aaa gaa Leu Lys Glu 195 atg gtc cgc Met Val Arg ctc eta gac gtg Leu Leu Asp Val tgc ggt tgg gga Cys Gly Trp Gly tac gcc Tyr Ala 215 gcc aaa cac qgt Ala Lys His Gly gtg Val1 220 aaa gcc ate gga Lys Ala Ile Gly gtt Val 225 acg ctg tct ga Thr Leu Ser Giu cag Gin 230 caa tat gag tgg Gin Tyr Giu Trp caa gca gag ate Gin Ala Giu Ile ege caa ggt ttg Arg Gin Gly Leu ga Giu 245 gac etc geg gaa Asp Leu Ala Giu att Ile 250 egc ttc atg gat Arg Phe Met Asp tac Tyr 255 cgc gat gtt cca Arg Asp Val Pro gaa act Glu Thr 260 gga ttc gat Gly Phe Asp aac aac tat Asn Asn Tyr 280 ate tca gca ate Ile Ser Ala Ile ggc Gly 270 atc att gaa eac Ile Ile Giu His atc ggt gtg Ile Giy Vai 275 etc ass aca Leu Lys Thr 931 979 ccc gac tac ttt Pro Asp Tyr Phe gaa Giu 285 ttg etc age age Leu Leu Ser Ser aaa Lys 290 gge gga Gly Gly 295 etg atg etc sac Leu Met Leu Asn age ate ace tac Ser Ile Thr Tyr eca Pro 305 gac aac ege ccc Asp Asn Arg Pro cac ges ggt gea His Ala Gly Ala att gat ege tac Ile Asp Arg Tyr ttc ccc gac ggt Phe Pro Asp Gly ga Glu 325 1027 1075 1123 etc act ggc tet Leu Thr Giy Ser ggc Gly 330 ace ctg ate aag Thr Leu Ile Lys cac His 335 atg cag gae sac Met Gin Asp Asn ggt ttc Gly Phe 340 gas gtg ctg Giu Vai Leu cac geg tgg His Ala Trp 360 gsa gaa ase etc Giu Giu Asn Leu ttt gat tac cas Phe Asp Tyr Gin ege aec ctg Arg Thr Leu 355 ges gtt gaa Ala Val Glu tgc gaa aac etc Cys Giu Asn Leu ass Lys 365 gaa sat tgg gag Giu Asn Trp Glu ga a Glu 370 1171 1219 1267 1315 etc gee Leu Aia 375 ggt gsa ccc act Gly Glu Pro Thr ega etc ttt ggc Arg Leu Phe Giy tao atg gca ggt Tyr Met Ala Gly teg gaa tgg gga ttt gee cac sac ate gte eag ctg cac esa gta ctg Ser Glu Trp 390 ggt gtg aaa Gly Val Lys atq tgg tgg Met Trp Trp Gly ctc Leu act Thr 425 Phe Ala His Asn Ile Val Gin Leu His Gin Val Leu 395 400 405 gat gag cag gga agt cgc gga gaa gtt cct gaa aga 1363 Asp Glu Gin Gly Ser Arg Gly Giu Val Pro Glu Arg 410 415 420 atc taaagaaaca atgtttcttt tta 1401 Ile <210> 68 <211> 426 <212> PRT <213> Corynebacterium giutamicun <400> 68 Met Thr Ile Ala Asp Ile Val Giu Ala 1 Phe Pro Thr Leu Al a Thr Gin Ile Ile 145 Asp Se r Le u Gly Val1 His Tyr Ala Ile Leu Leu Glu Asn 130 Ser Asp Leu Arg Glx' 210 Th r Ile Thr Gin Leu Pro Gly Val Giu Lys Glu Gin Ile 100 Ile Pro 115 Gix' Leu Tyr His Ser Met Glu Gilu 180 Leu Lys 195 Met Val Leu Ser 5 Ala ?he Asp Gl y Phe Met Pro Al a Tyr Thr 165 Al a Glu Arg Glu Phe Val1 Leu Glu 70 Tyr Trp Met Ser Asp 150 Tyr Gin Giy Tyr Gin Asp Ala Gly 55 His Arg Thr Giu Arg 135 Val1 Thr Glu Asp Ala 215 Gin Gly As n 40 Leu Pro Cx's Le u Gin 120 His Gly Cys As n Arg 200 Ala Tyr Se r 25 Thr Al a Gl y Phe Arq 105 Al a Ser Asn Ala Lys 185 Le u Lys Giu Thr 10 Phe Asp Arg His Lys 90 Lys Pro Lys Giu Tyr 170 Tyr Leu His T rp Thr Thr Ala Al a Pro 75 Arg Met Ala Ser Phe 155 Tyr Arg Asp Glx' Glx' Thr Gly Val1 Tyr Tyr Pro As n Trp Arg 140 Tyr Pro Le u Val1 Va 1 220 Gin Ala Pro S er Leu Giy Asp Ala Arg 125 Asp Ser Thr Ile Glx' 205 Lys Ala Pro Glu Tyr Met Ile Ala Le u 110 Lys Lys Le u Pro Phe 190 Cx's Al a Glu Ile Asp Ile Gly Phe Ser Lys Ala Ly's Phe Giu 175 Glu Cix' Ile Ile Pro Ala Al a Asp Asp Thr Phe Leu Ala Leu 160 Se r Ly's Trp, Gly Lys 225 230 235 240 Arg Gin Gly Leu Gin Asp Leu Ala Gin Ile Arg Phe Met Asp Tyr Arg 245 250 255 Asp Vai Pro Gin Thr Gly Phe Asp Ala Ile Ser Ala Ile Gly Ile Ile 260 265 270 Gin His Ile Gly Val Asn Asn Tyr Pro Asp Tyr Phe Gin Len Leu Ser 275 280 285 Ser Lys Leu Lys Thr Gly Gly Leu Met Leu Asn His Ser Ile Thr Tyr 290 295 300 Pro Asp Asn Arg Pro Arg His Ala Giy Ala Phe Ile Asp Arg Tyr Ile 305 310 315 320 Phe Pro Asp Gly Gin Leu Thr Gly Ser Gly Thr Leu Ile Lys His Met 325 330 335 Gin Asp Asn Giy Phe Giu Val Leu His Giu Glu Asn Len Arg Phe Asp 340 345 350 Tyr Gin Arg Thr Leu His Ala Trp Cys Giu Asn Len Lys Gin Asn Trp 355 360 365 Gin Gin Ala Val Giu Leu Ala Gly Glu Pro Thr Ala Arg Len Phe Giy 370 375 380 Len Tyr Met Ala Giy Ser Glu Trp Gly Phe Ala His Asn Ile Val Gin 385 390 395 400 Len His Gin Val Leu Gly Val Lys Len Asp Giu Gin Gly Ser Arg Gly 405 410 415 Gin Vai Pro Gin Arg Met Trp Trp Thr Ile 420 425 <210> 69 <211> 1437 <212> DNA <213> Corynebacterinm giutamicun <220> <221> CDS <222> (101)..(1414) <z223> RXA02029 <400> 69 cgcacgtaca ctacttttag cagttaaccc gccgaacttt cttgattaaq tattcattqa gcgttcttgg cataaatccc actggaqgtg catcaaacqt atg gca gag gca cgt 115 Met Ala Gin Ala Arg 1 ttg cgc cat ctt gaa ccc att gat gtg gaa gag tgg cct. qgg gtq gog 163 Len Arg His Len Gin Pro Ile Asp Val Gin Gin Trp Pro Gly Val Ala 15 tca gtq ccc aac cta gcg ttt gct ggt gca cgc gca cgg caa gca gaa 211 Ser Val Pro tat cga ttt Tyr Arg Phe Leu Ala Phe Ala Ala Arg Ala Arg Gln Ala Glu etg cta gga Leu Leu Gly gcc aag gcc tgc Ala Lys Ala Cys agc Ser aac gca ggt tta Asn Ala Gly Leu aat gac Asn Asp ceg gat ctc att Pro Asp Leu Ile gat cat gag gaa Asp His Glu Glu tta Leu ttc tca cgt ttg Phe Ser Arg Leu gcc Al a gca teg ggc tgg Ala Ser Gly Trp ctg Leu ggg etc get gag Gly Leu Ala Glu tac atg gca ggc Tyr Met Ala Gly tgg cgc agc gag Trp Arg Ser Glu ctt gcc gac gtc Leu Ala Asp Val ttg Leu ace get ttg ttg Thr Ala Leu Leu gga act Gly Thr 100 ggg ttt aaa Gly Phe Lys caa get gtg Gin Ala Val 120 ccc Pro 105 cgc ggc aaa eta Arg Gly Lys Leu gga teg tte ace Gly Ser Phe Thr ctg eca ggg Leu Pro Gly 115 att. cgt tta Ile Arg Leu gat gee gga ggc Asp Ala Gly Gly cta eec aat gaa Leu Pro Asn Giu etc Leu 130 agt tea Ser Ser 135 ggt qat ggc atg Gly Asp Gly Met agc Ser 140 gea ttt ggt gga Ala Phe Gly Gly ttt gee tee ggt Phe Ala Ser Gly eca ace act tta Pro Thr Thr Leu aec gca gtg aaa Thr Ala Val Lys cat gtg ccg gga His Val Pro Gly ggt cge aat agg Gly Arg Asn Arg gag Glu 170 ccc gca tet cac Pro Ala Ser His gtg gat ate ace Val Asp Ile Thr aag ate Lys Ile 180 teg gag cet Ser Giu Pro ega gea geg Arg Ala Ala 200 gee gtg gag cgt Ala Val Glu Arg gaa qac etc gge gag get eag cqe Glu Asp Leu Gly Glu Ala Gin Arg 190 195 tee ttt ttg ctt Ser Phe Leu Leu gge gee aaa gtt Gly Ala Lys Val aaa L ys 210 gee gga age Ala Gly Ser cat gtg His Val 215 ttg gag ttt ccc Leu Glu Phe Pro agc Ser 220 agt ggt gga get Ser Gly Gly Ala get. att ttg get Ala Ile Leu Ala ega ege cag gga Arg Arg Gin Gly gtt gae get tta Val Asp Ala Leu aeg Thr 240 get gat ccc geg Ala Asp Pro Ala caa Gin 245 gtt tea age etg Val Ser Ser Leu gag Glu 250 qag aeg ttt gtg Glu Thr Phe Val gee ggt gtg gag Ala Gly Val Giu gag gat Giu Asp 260 att. cac ate gag gte att ccc cag geg att ccc tcg eca cgc gaa tgg Ile His Ile Glu Val Ile Pro Gin Ala Ile Pro Ser Pro Arg Giu Trp ggt ggc gcc tac gat tcg ata Gly Gly ggc aag Gly Lys 295 aco acc Thr Thr 310 tgg agt Trp Ser tgg cct Trp Pro gat agg Asp Arg cat tac His Tyr 375 ata cqc Ile Arg 390 tgg gtg Trp Val ctc aat Leu Asn Al a 280 cac His ggc Gly cct Pro g cgJ Al a ga t Asp 360 ct a Le u gaa Glu tat Tyr gca Ala Tyr ggt Gly 9gC Gly gtg Val1 ctg Leu 345 t ct Ser aaa Lys gcg Al a cac His gtg Val1 425 Asp Ser tcc aag Ser Lys aac gta Asn Val 315 tgt tot Cys Ser 330 cat tac His Tyr tot ctg Ser Leu agc gtg Ser Val gcg gca Ala Ala 395 tao gcg Tyr Ala 410 caa ttt Gin Phe Ile Cgg Arg 300 gcc Ala gaa Giu c ca Pro 090 Arg cag Gin 380 gat Asp Ott Leu gog Ala gt c Val1 285 ttt Phe atg Met gcg Ala act Th r qt g Val1 365 ttq Le u ggo Gi y att Ile ttg Leu 270 gc Ala att Ile caa Gin att Ile gt t Val1 350 gtg Val1 caa Gin ttt Phe qa a Giu a og Thr 430 atg gag aag ota gaa gtg gtg Met Giu Lys aaa Lys t cc Se r tot Ser 335 ga t Asp aag Lys ogt Arg ga t Asp qcc Al a 415 aca Thr a to Ile 305 gta Val ot 0 Leu gtt ValI aca Thr gtq Val 385 gtc Val tta Leu aac Asn Leu Glu 290 gao aga Asp Arg got act Ala Thr aag g00 Lys Ala cat cag His Gin 355 cac ttt His Phe 370 ttt gaa Phe Giu tac oqo Tyr Arg cgc ctg Arg Leu aga agg Arg Arg 435 Val1 atg Met gao Asp tat Tyr 340 ott Leu gog Al a ggc Gly ogo Arg gga Gly 420 ggg Gly 979 1027 1075 1123 1171 1219 1267 1315 1363 1411 1437 cga Arg taagoaaaaa tottttagao otc <210> <211> 438 <212> PRT <213> Corynebacterium glutamioum <400> Met Ala Giu Ala Arg Leu Arg His Leu Glu Pro Ile Asp Val Glu Giu 1 5 10 Trp Pro Giy Val Ala Ser Vai Pro Asn Leu Ala Phe Ala Giy Ala Arg 25 Aia Arg Gin Ala Giu Tyr Arg Phe Ala Lys Ala Oys Ser Asn Ala Gly 40 Leu Val Leu Leu Gly Asn Le u Tyr Ala Ph e Glu Val1 145 His Asp Gl y Val Le u 225 Al a Gl y Ser Lys Ile 305 Val1 Leu Val1 Ser Al a Le u Le u 115 Ile Al a Pro Thr Al a 195 Al a Ile Pro Gi u Arg 275 Glu Arg Thr Al a Gin 355 Arg Gly Gly 100 Pro Arg Ser Giy Lys 180 Gin Gly Leu Ala Giu 260 Giu ValI Met Asp Tyr 340 Leu Leu Glu Thr Gly Leu Gi y Al a 165 Ile Arg Ser Al a Gin 245 Asp Trp Val1 Leu Gin 325 Ile Val1 Asp 55 Al a Arg Phe Al a Ser 135 Pro Arg Giu Aia Val 215 Arq Ser His Gly Lys 295 Thr Ser Pro Arg Pro Asp Leu Ile Ile Asp His Giu Glu Ser Ser Lys Val1 120 Gly Thr Asn Pro Al a 200 Le u Arq Ser Ile Ala 280 His Gly Pro Al a Asp 360 Gly Giu Pro 105 Asp Asp Thr Arg Val1 185 Ser Glu Gin Le u Glu 265 Tyr Gly Gly Val1 Leu 345 Ser Leu 75 Leu Gly Gly Met Arg 155 Pro Val1 Leu Pro Thr 235 Giu Ile Ser Lys Val1 315 Ser Tyr Le u Giy Ala Lys Gly Ser 140 Thr Ala Giu Leu Ser 220 Val1 Thr Pro Ile Arg 300 Ala Giu Pro Arg Leu Asp Leu Ala 125 Al a Ala Ser Arg Asp 205 Se r Asp Phe Gin Val1 285 Phe Met Ala Thr ValI 365 Ala Val1 Se r 110 Le u Phe Val1 His Glu 190 Gi y Gi y Ala Val1 Al a 270 Al a Ile Gin Ile Val1 350 Val1 Se r Thr Se r As n Gi y Se r 160 Val1 Le u Lys Aila Thr 240 Al a Pro Giu Ala Le u 320 Le u Giu Glu Thr Val1 385 Val1 Leu Asn His 370 Phe Tyr Arg Ar g Phe Giu Ar g Leu Arg 435 Ala Gly Arg Gly 420 Gly His Tyr Leu Lys Ser Val Gin Leu Gin Arg Giu 375 380 Ile Arg Giu Ala Ala Ala Asp Gly Phe Asp Ala 390 395 400 Trp Val Tyr His Tyr Ala Leu Ile Glu Ala Leu 410 415 Leu Asn Ala Val Gin Phe Ala Leu Thr Thr Arg 425 430 Arg <:210> 71 <211> 1140 <212> DNA <213> Coryriebacterium giutamicum <220> <221> CDS <222> (1117) <223> RXA01801 <400> 71 tttgqattcc tttccgatta tgtcttgatc gcccattCtg tcacatccgg gttgtctaaa cacccgcgaa gatttcctgt gatgtgccac actggttctc atg tct aac gta gtg Met Ser Asn Val Val act Th r gcg Al a eta Leu t ca Se r cg t Arg atc I le gtc Val1 aat Asn act Thr t cg Ser agc Ser gag Glu aat Asn ctt Leu get Ala cgt Arg ttg Leu geg Ala tee Ser aat Asn ga t Asp gea Ala 60 gag Glu atg Met ggt Gly gaa Giu 30 gat Asp tgt Cys gat Asp aac Asn gtg Val1 at c Ile gtg Val ggc Gly 909 Ala 80 ttg Leu 1 gag Giu gat Asp eag Gin ggt Gly 65 9C Ala gga Gly ctt Le u etc Leu ea g Gin 50 ga t Asp gyc Gi y ac Thr ccc Pro ga a Giu att Ile gcg Al a tat Tyr aag Lys ecg gtc att tet Pro Val Ile Ser 105 gtg ate aae gge Vai Ile Asn Gly gtc gcg atg ggt gge gqa atg gga 11011 Gly Met Gly 115 att tcc atg Ile Ser Met 120 cat gga tcg cac His Gly Ser His cgg Arg 125 atc gtc acg gaa Ile Val Thr Glu gcg ttc gcg Ala Phe Ala tcg atg Ser Met 135 cct gag atg gcg Pro Glu Met Ala ggC tat gtt ccc gat gtg ggc ttt act Gly Tyr Val Pro Asp Val Gly Phe Thr 145 ttc ggt cag cgt Phe Gly Gin Arg tcg tcg ctg gcc Ser Ser Leu Ala goc aca ttt ttg Ala Thr Phe Leu gtg acc ggg tgg Val Thr Gly Trp cg c Arg 170 atg agc cct gcc Met Ser Pro Ala ga t Asp 175 atg ctg tgg gct Met Leu Trp Ala ggc gtc Gly Val 180 gca acg cat Ala Thr His aac gag tcg Asn Giu Ser 200 gtt gag gat gcg Val Giu Asp Ala ggg ttc att gat Gly Phe Ile Asp gqg gtc ttg Ala Val Leu 195 caa cct acg Gin Pro Thr 691 739 ctt gat ggc gcg Leu Asp Gly Ala ctg Le u 205 gag aaa ttc tcc Giu Lys The Ser ggc agc Gly Ser 215 agc gag ctg gcc Ser Glu Leu Ala qtc gcc agc cag Vai Ala Ser Gin gag gag acc ttt Glu Giu Thr Phe ggg Gly 230 cac aqc tct tgg His Ser Ser Trp ctt atc gac gcc Leu Ile Asp Ala tcc Ser 240 ctc cgg tct cac Leu Arg Ser His 787 835 883 gat gct gaa ttt Asp Ala Giu The gtt Vali 250 gcc aag gtg gat Ala Lys Val Asp 1999 Gly 255 Ctg atq gcg tcg Leu Met Ala Ser gca gca Ala Ala 260 ccg gca tcg Pro Ala Ser gcg acc act Ala Thr Thr 280 gtg gct acc gtg Val Ala Thr Val ctg atg cat caa Leu Met His Gin aac aqt gag Asn Ser Glu 275 atg tct ctt Met Ser Leu ctg cgt gaa ggc Leu Arg Glu Gly ttg Leu 285 gac aat gaa ttg Asp Asn Giu Leu tat atg Tyr Met 295 atc cgc cag cct Ile Arq Gin Pro ttt gct gaa ggt Phe Ala Giu Gly cgt gca gtg ttg Arg Ala Val Leu gat aaa gac cgc Asp Lys Asp Arg gca gcc ttc tcc Ala Ala Phe Ser gcc aac tac gaa Ala Asn Tyr Giu cgc agt tca Arg Ser Ser gat Asp 325 1027 1075 1117 gtt gat gag tca Val Asp Glu Ser ttt gtg acc ttg Phe Val Thr Leu ttc cag Phe Gin 335 taaaaccgcc aaacttttqa tag <210> 72 <211> 339 1140 <212> PRT <213> Gorynebacterium glutamicum <400> 72 Met Ser Asn Val Val Asn Thr Phe Val 1 Giu Asp Gin Gly Ala Gly Gly Giu Asp 145 Ala Leu Ile Ser Ile 225 Leu Met His Le u Le u Gin Asp Gi y Thr Gi y Lys 130 Val1 Thr Trp Asp Thr 210 Glu Arg Al a Gin Asn Val1 Val1 ValI Asp Tyr Gly 115 Al a Gly Phe Ala Al a 195 Gin Gi u Ser Ser As n 275 Arg Gin Leu Arg Lys Pro 100 Met Phe Phe Leu Gly 180 Val Pro Thr His Ala 260 Ser 5 Pro Giu Ile Ala Tyr Lys Gly Al a Thr Al a 165 Val1 Le u Thr Phe Pro 245 Ala Glu Lys Al a Tyr Val 70 Phe Pro Ile Ser Tyr 150 Val1 Al a Asn Gi y Gi y 230 Asp Pro Al a Ala Le u Ser 55 Arg Ile Vai Ser Met 135 Phe Thr Thr Giu Ser 215 His Ala Ala Thr Le u Thr 40 Ser Giu Asp Ile Met 120 Pro Gly Gly His Ser 200 Ser Ser Giu Ser Thr 280 Asn Thr Ser Ser Giu Ser 105 His Giu Gin Trp Phe 185 Leu Glu Ser Phe Val1 265 Leu Gin 10 Ser Trp Giu Val1 Phe 90 Val1 Gly Met Ar g Arg 170 Val Asp Leu Trp Val1 250 Val Arg Asn Leu Ala Arg Leu 75 Ala Ile Ser Ala Ala 155 Met Giu Gi y Al a Ala 235 Ala Ala Glu Ser Asn Asp Ala Glu Met Asn His Ile 140 Ser Ser Asp Ala Gly 220 Le u Lys Thr Gly Thr Gin Asp Phe Gly As n Gly Arg 125 Gly Ser Pro Al a Leu 205 Val1 Ile Val1 Val Le u 285 Met Met Gin Al a Val1 Thr Ala Val Val Ala Asp 175 Gly Lys Ser Ala Gly 255 Leu Asn Val1 Ile Val1 Gi y Al a Leu Met Thr Pro Ile 160 Met Phe Phe Gin Ser 240 Leu Met Glu Leu Ala Met Ser Leu Tyr Met Ile Arg Gin Pro Asp Phe Ala Giu Gly Val Arg Ala Val Leu Val Asp Lys Asp Arg Asn Ala Ala Phe Ser Pro 305 310 315 320 Ala Asn Tyr Glu Asp Val Asp Glu Ser His Phe Val Thr Leu Phe Gin 325 330 335 Arg Ser Ser <210> 73 <211> 1086 <212> DNA <213> Gorynebacterium giutamicum <220> <221> CDS <222> (1063) <223> RXN02512 (400> 73 gctggaaagt ccccattggc taaqgaattt accaaggcac cagcaggtgc gaaggcagat tacagcaaca ccaaataaaa attagccgag ggagcatcqc atg aag ccg aag gat Met Lys Pro Lys Asp ttc Phe cta Leu Cgg Arg atg Met gtt Val1 t gg Trp ctt Leu tct Ser aac Asn aca Thr ggt Gly ttt Phe cag Gin cag Gin ga a Glu cgg Ar g gct Al a 120 ga t Asp gcg Al a t gq T rp ga c Asp eta. Le u gcg Al a gcg Ala ttg Le u 105 gc Al a atg Met aat Asn ttt Phe ggg Gly gct Ala gtg Val 75 cgg Arg aag Lys aag Lys gg9C Gly t gg T rp gtc Val gcg Ala aat Asn aag Lys eta Leu gga Gly qgc Gly get Ala gag Glu atg Met 30 ct g Leu gcg Al a gca Al a gcg Al a qt t Val1 110 gt t Val1 ctq Le u aa t Asn ctc Leu gcg Al a Cgg Arg aeg Thr atc Ile ggc Gly ttg Le u att Ile gca Ala Cct Pro age Ser 50 ggt Gly tat Tyr ga t Asp ttg Leu c ca Pro 130 cat His ctg Leu att Ile 35 gga, Gly gcg Ala gcg Ala cct Pro ttg Leu 115 cac His ggg Gly ggc Gly 20 gct Ala aaa Lys gaa Glu egg Arg gag Glu 100 gat Asp agc Ser caa Gin tat Tyr cgc Arg ggC Gly aac Asn tat Tyr ctg Leu gaa Glu ggc Gly ttc Phe 140 145 ace Thr 150 ace gtt gea gaa Thr Val Ala Glu gtc aag ccg gaa Val Lys Pro Giu ttg ttt gaa gcg Leu Phe Glu Ala 595 643 gtg gag ttt cga Val Glu Phe Arg gaa Glu 170 age ctt gga ttt Ser Leu Gly Phe gag Glu 175 gtg ctg ect etc Val Leu Pro Leu ace ggt Thr Gly 180 ggc gag Ogt Gly Glu Arg ggt atc qtg Gly Ile Val 200 cog ttt gaa aag Pro Phe Glu Lys aaa gag ego ctg Lys Giu Arg Leu aca tot gga Thr Ser Gly 195 tee ggc gtg Ser Gly Val tgo ott ott ggg Cys Leu Leu Gly gag Glu 205 ogt gao otg egg Arg Asp Leu Arg gag aoo Glu Thr 215 act ttt ttt ggt Thr Phe Phe Gly gag Glu 220 aag aco too atg Lys Thr Ser Met oca Pro 225 goa gga oot gog Ala Gly Pro Ala cag Gin 230 otg gco att gaa Leu Ala Ile Glu aca Thr 235 ggt gog gcg otg Gly Ala Ala Leu ca o His 240 gtg gtg oat oca Val Val His Pro ttc gat gao gao Phe Asp Asp Asp ggo Gly 250 tgg gyt etc ago Trp Gly Leu Ser too gat goc gtg Ser Asp Ala Val aco gtg Thr Val 260 gat aat tta Asp Asn Leu aat att aog Asn Ile Thr 280 gao acg gtg cag Asp Thr Val Gin ato gea cat ctt Ile Ala His Leu ttt atg gca Phe Met Ala 275 coo otg tgg Pro Leu Trp 931 979 gog cac ccc get Ala His Pro Ala ga t Asp 285 tgg cat atg etc Trp His Met Leu ttt ggt Phe Gly 295 gat ttg gat cog Asp Leu Asp Pro egt oto aag ego Arg Leu Lys Arg tot Ser 305 Arg Glu Gin Thr taggtgcgaa 1027 aat Asn 310 gtt eac aaa Oog Val His Lys Pro gtg Val 315 gea tta cag gag Ala Leu Gin Glu gao aat Asp Asn 320 1073 ttggaatggt otg <210> 74 <211> 321 <212> PRT <213> Corynebacterium glutamicun <400> 74 Met Lys Pro Lys Asp Phe Cys Thr Ala 1086 Glu Asn Trp Ala Glu Asn Leu Ser Ala Leu Gly Tyr Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro 25 Leu Pro Ile Ala Arg Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser 40 Lys Ser Gly Lys Gly Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val 55 Val Gly Ala Glu Asn Val Thr Gin Ala Leu Val Lys Gin Ala Thr Arg 70 75 Ser Tyr Ala Arg Tyr Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala 90 Arg Asp Pro Glu Leu Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu 100 105 110 Asp Leu Leu Asp Glu Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr 115 120 125 Leu Pro His Ser Gly Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser 130 135 140 His His Gly Gin Phe Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg 145 150 155 160 Leu Phe Glu Ala Phe Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val 165 170 175 Leu Pro Leu Thr Gly Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu 180 185 190 Arg Leu Thr Ser Gly Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu 195 200 205 Arg His Ser Gly Val Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met 210 215 220 Pro Ala Gly Pro Ala Gin Leu Ala Ile Glu Thr Gly Ala Ala Leu His 225 230 235 240 Val Val His Pro Trp Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser 245 250 255 Asp Ala Val Thr Val Asp Asn Leu Ser Asp Thr Val Gin Arg Ile Ala 260 265 270 His Leu Phe Met Ala Asn Ile Thr Ala His Pro Ala Asp Trp His Met 275 280 285 Leu Gin Pro Leu Trp Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg 290 295 300 Ser Arg Glu Gin Thr Asn Val His Lys Pro Val Ala Leu Gin Glu Asp 305 310 315 320 Asn <210> <211> 1057 <212> DNA (213> Corynebacterium glutarnicum <220> <221> ODS <222> (1057) <223> FRXA02512 <400> gotggaaagt cccattggc taaggaattt acoaaggcac tacagcaaca ccaaataaaa attagcogag ggagcatcgc cagcaggtgc gaaggcagat atg Met 1 aag cog aag Lys Pro Lys ttc tgc aca gcg Phe Cys Thr Ala aat tgg gcg gag Asn Trp Ala Giu aa t As n tta ago gca otg Leu Ser Ala Leu ggo tat Gly Tyr ota gct ggt Leu Ala Gly cgg gtg ttt Arg Val Phe tgg Trp ogt ttt gtc ogg Arg Phe Val Arg oto ct. ttg Oct Leu Pro Leu Pro att got ogc Ile Ala Arg gga aaa ggc Gly Lys Gly gao ott. ggg gog Asp Leu Gly Ala otg gog tog aaa Leu Ala Ser Lys atg ggg Met Gly cag cta ogo got Gin Leu Arg Ala otg gog cgg gtg Leu Ala Arg Val gt 0 Val1 ggt gog gaa aao Gly Ala Glu Asn aog oag gog ctg Thr Gin Ala Leu gtg Val1 aag oaa goa. aog Lys Gin Ala Thr ago tat gog ogg Ser Tyr Ala Arg tgg otg gaa gcg Trp Leu Giu Ala cgg ota cog gog Arg Leu Pro Ala ato Ile gog oga gat oct Ala Arg Asp Pro gag otg Glu Leu 100 ott gog ogg Leu Ala Arg tot ttg got Ser Leu Ala 120 ttg Le u 105 ogt aag gga aot Arg Lys Gly Thr ggc ota gat ttg Gly Leu Asp Leu ttg gat gaa Leu Asp Glu 115 cac ago ggo His Ser Gly goc ggo aag ggc Ala Gly Lys Gly gtt ttg aog oto Val Leu Thr Leu aao tgg Asn Trp 135 gat atg gct ggo Asp Met Ala Gly ttt. otg att ago Phe Leu Ile Ser oat His 145 cat ggg caa tto His Gly Gin Phe aoc gtt gca gaa. Thr Val Ala Giu agg Arg 155 gto aag cog gaa Val Lys Pro Glu ttg ttt gaa gcg Leu Phe Glu Ala gtg gag ttt cga Val Glu Phe Arg ago ctt gga ttt Ser Leu Gly Phe gag Gi u 175 gtg otg oot ctc Val Leu Pro Leu aoo ggt Thr Gly 180 ggc gag ogt Gly Glu Arg cog Pro 185 cog ttt gaa aag Pro Phe Glu Lys ctg Leu 190 aaa gag ogo otg Lys Glu Arg Leu aca tot gga Thr Ser Gly 195 gqt atc gtg tgc ctt ctt ggg gag cgt gac ctg cgg cat tcc ggc gtg 739 Gly Ile Val Cys Leu Leu Gly Glu Arq Asp Leu Arg His Ser Gly Val 200 205 210 gag acc act ttt ttt ggt gag aag acc tcc atg cca qca qga cct gcg 787 Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met Pro Ala Gly Pro Ala 215 220 225 cag ctg gcc att gaa aca ggt gcg qcg ctg cac gtg gtg cat cca tgg 835 Gin Leu Ala Ile Giu Thr Gly Ala Ala Leu His Val Val His Pro Trp 230 235 240 245 ttc gat gac gac ggc tgg gqt ctc agc gta tcc gat gcc gtq acc gtg 883 Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser Asp Ala Val Thr Val 250 255 260 gat aat tta tcc gac acg gtg cag cgg atc gca cat ctt ttt atg gca 931 Asp Asn Leu Ser Asp Thr Val Gin Arg Ile Ala His Leu Phe Met Ala 265 270 275 aat att acg gcg cac ccc gct gat tgg cat atg ctc caa ccc ctq tgq 979 Asn Ile Thr Ala His Pro Ala Asp Trp His Met Leu Gin Pro Leu Trp 280 285 290 ttt ggt gat ttg qat ccg gag cgt ctc aag cgc tct agg gag cag aca 1027 Phe Gly Asp Leu Asp Pro Giu Arg Leu Lys Arg Ser Arg Giu Gin Thr 295 300 305 aat gtt cac aaa ccg gtg gca tta cag gag 1057 Asn Val His Lys Pro Val Ala Leu Gin Giu 310 315 <210> 76 <211> 319 <212> PRT <213> Corynebacterium giutamicum <400> 76 Met Lys Pro Lys Asp Phe Cys Thr Ala Giu Asn Trp Ala Glu Asn Leu 1 5 10 Ser Ala Leu Gly Tyr Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro 25 Leu Pro Ile Ala Arg Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser 40 Lys Ser Gly Lys Gly Met Gly Gin Leu Afg Ala Asn Leu Ala Arg Val 55 Val Gly Ala Glu Asn Val Thr Gin Ala Leu Val Lys Gin Ala Thr Arg 70 75 Ser Tyr Ala Arg Tyr Trp Leu Giu Ala Phe Arg Leu Pro Ala Ile Ala 90 Arg Asp Pro Glu Leu Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu 100 105 110 Asp Leu Leu Asp Glu Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr 115 120 125 Leu Pro His Ser Gly Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser 130 135 140 His His Gly Gln Phe Thr Thr Val Ala Giu Arg Val Lys Pro Glu Arg 145 150 155 160 Leu Phe Giu Ala Phe Val Glu Phe Arq Glu Ser Leu Gly Phe Glu Val 165 170 175 Leu Pro Leu Thr Gly Gly Giu Arg Pro Pro Phe Glu Lys Leu Lys Giu 180 185 190 Arq Leu Thr Ser Gly Gly Ile Val Cys Leu Leu Gly Giu Ar4 Asp Leu 195 200 205 Arg His Ser Gly Val Giu Thr Thr Phe Phe Gly Giu Lys Thr Ser Met 210 215 220 Pro Ala Gly Pro Ala Gin Leu Ala Ile Giu Thr Gly Ala Ala Leu His 225 230 235 240 Val Val His Pro Trp Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser 245 250 255 Asp Ala Val Thr Val Asp Asn Leu Ser Asp Thr Val Gin Arg Ile Ala 260 265 270 His Leu Phe Met Ala Asn Ile Thr Ala His Pro Ala Asp Trp His Met 275 280 285 Leu Gin Pro Leu Trp Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg 290 295 300 Ser Arg Giu Gin Thr Asn Val His Lys Pro Val Ala Leu Gin Giu 305 310 315 (210> 77 <211> 1389 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(1366) <223> RXA00899 (400> 77 tttgctgctc ccctacgtcg gactcccact gttcctgctt atqqqatcgc catacatcaa ccggtgacgc caccgcatcc aacaagaaat caacgacctc atg gaa gac gic cac 115 Met Giu Asp Val His 1 gac qac gtc ccc gac atc ccc acc gqa atqgqat qtc tcc gcg qaa gtt 163 Asp Asp Val Pro Asp Ile Pro Thr Gly Met Asp Val Ser Ala Giu Val 15 gaa tct gtc Glu Ser Val acc ggc gga Thr Gly Gly aaa ctc aac cgc Lys Leu Asn Arg cgc Arg ctc acc cgc atg Leu Thr Arg Met cca gca gtg Pro Ala Val tcc ctc aaa Ser Leu Lys 211 259 aac aac ggc ttc Asn Asn Gly Phe tcc gac tac cgt Ser Asp Tyr Arg cgg atg Arg Met ace gcc gca ate Thr Ala Ala Ile gaa gee gaa gaa Glu Ala Glu Glu atc tac gte gag Ile Tyr Val Glu tac ate atg gc Tyr Ile Met Ala t gg Trp gat tec tac ace Asp Ser Tyr Thr cca ttc ttc gca Pro Phe Phe Ala gca Al a ctc gaa cqa gcc Leu Glu Arg Ala aac cgc ggc gtc Asn Arg Gly Val aaa Lys qtc cga ctc ctt Val Arg Leu Leu ttc gac Phe Asp 100 cac gte ggc His Val Gly etc aac cgc Leu Asn Arg 120 agc Ser 105 tgg aaa tac ccc Trp Lys Tyr Pro tac cac cgc ctc Tyr His Arg Leu aaa aaa gaa Lys Lys Glu 115 ctc caa ccc Leu Gin Pro atg ggc ttc gcc Met Gly Phe Ala t gg Trp 125 tac ctc atg ctc Tyr Leu Met Leu tgg cga Trp Arg 135 cgc cgc ttc cgc Arg Arg Phe Arg ccc gac ctg cgc Pro Asp Leu Arg cac cgc aaa atg His Arg Lys Met ctc Leu 150 atc atc gac ggc Ile Ile Asp Gly acc gca ttc atg Thr Ala Phe Met tec caa aat ctc Ser Gin Asn Leu atc Ile 165 gcc ccg agt tac Ala Pro Ser Tyr cta Leu 170 caa aag aaa aac Gin Lys Lys Asn atc Ile 175 aaa ctc ggc cgc Lys Leu Gly Arg gaa tgg Giu Trp 180 aaa gac ctc Lys Asp Leu atg ate ttc Met Ile Phe 200 gtc gaa ctc acc Val Glu Leu Thr ggc Gly 190 ccc ate gtc tcc Pro Ile Val Ser tcc atg gaa Ser Met Giu 195 gcc etc gac Ala Leu Asp gcc gqc gac tgg Ala Gly Asp Trp gtc gaa tcc aac Val Glu Ser Asn atc cgc Ile Arg 215 gac cac gca gaa Asp His Ala Glu gcc Al a 220 cac ggc tac atc His Gly Tyr Ile aac act caa aaa Asn Thr Gin Lys tcc gcc acc aac Ser Ala Thr Asn ctc Le u 235 gtg cag etc atc Val Gin Leu Ile ccc Pro 240 tcc ggc cct ggt Ser Gly Pro Gly acc aca gaa ccc Thr Thr Giu Pro ctg cqc atg ttc Leu Arg Met Phe tcc ate gtt cac Ser Ile Val His cac gcc His Ala 260 aaa gaa cga etc ate ttg tgc age ccc tac ttc atc ccc gac gaa tee Lys Giu Arg ctc ctc gaa Leu Leu Glu 280 Ile Leu Cys Ser Pro 270 Tyr Phe Ile Pro Asp Giu Ser 275 acc qtc gaa Thr Val Giu gcc gto aoc toa Ala Val Thr Ser tgo tac ogc gga Cys Tyr Arg Gly cta ttc Leu Phe 295 gtc tct gaa caa Val Ser Giu Gin gcc Al a 300 gac caa ttc gcc Asp Gln Phe Ala atc Ile 305 gac cac gcc caa Asp his Ala Gin tc Ser 310 tcc tac tac cag Ser Tyr Tyr Gin ctc ctt gaa gcc Leu Leu Giu Ala gtg aaa atc tac Val Lys Ile Tyr ca a Gin 325 1027 1075 112] ttc ccc aaa ccc Phe Pro Lys Pro gto ctc cac acc Val Leu His Thr aag Lys 335 tac atg atc gcc Tyr Met Ile Ala gac coo Asp Pro 340 gac gac acc Asp Asp Thr ctc gac ato Leu Asp Ile 360 acc Tb r 345 ggc aac gaa gcc Gly Asn Giu Ala qga qtc cto qga Gly Val Leu Gly tcc tcc aac Ser Ser Asn 355 ctg atg atc Leu Met Ile 1171 1219 cgc agc ttt ggc Arg Ser Phe Gly oto Leu 365 aac tao gaa ato Asn Tyr Glu Ile too Ser 370 goc aaa Ala Lys 375 ggc aac otc ato Giy Asn Leu Ile gaa oto aao gco Giu Leu Asn Ala aco gao ogt tao Thr Asp Arg Tyr cgo Arg 390 aca gta agt tto Thr Vai Ser Phe cto aoo ttg gat Leu Thr Leu Asp tgg aao oag ogo Trp Asn Gin Arg agqt Ser 405 1267 1315 1363 tgg ogg ogo ogo Trp Arg Arg Arg tao T yr 410 gtg gao aat gto Val Asp Asn Val at 9 Met 415 ogt ttg aoc tog Arg Leu Thr Ser gog ctg Ala Leu 420 oag Gin tagtttggog ogtttggagt gog 1389 <210> 78 <211> 422 <212> PRT (213> Corynebaoterium giutarnicum (400> 78 Met Giu Asp Val His Asp Asp Val Pro Asp 1 5 10 Ile Pro Thr Gly Met Asp Val Ser Ala Giu Val Giu Ser Vai Ile 25 Arg Met Pro Ala Vai Thr Gly Gly Asn Lys Leu Asn Arg Arq Leu Thr Asn Gly The Tyr Ser Asp Tyr Arg Giu Ser Leu Lys Arg Met Thr Ala Ala Ile Asp 55 Giu Ala Giu Giu Tyr Ile Tyr Val Giu Ile Tyr Ile Met Ala Pro Arg Arg Leu As n 145 S er Leu Val1 Asn Gly 225 Ser Ile Ile Gly Ile 305 Val1 Met Leu Phe Leu Leu Pro 130 His Gin Gly Se r Glu 210 Asri Gly Val1 Pro Val 290 Asp Lys Ile Gly Phe Leu Lys 115 Le u Arg As n Arg Ser 195 Ala Thr Pro His Asp 27 5 Thr His Ile Ala Ser 355 Ala Phe 100 Lys Gin Lys Leu Glu 180 Met Leu Gin Gly His 260 Giu Val1 Ala Tyr Asp 340 Ser Al a Asp Glu Pro Met Ile 165 Trp Glu Asp Lys Tyr 245 Ala Ser Glu Gin Gin 325 Pro Asn 70 Leu His Leu Trp Leu 150 Al a Lys Met Ile Asp 230 Thr Lys Le u Le u Ser 310 Phe Asp Le u Glu Val1 Asn Arg 135 Ile Pro Asp Ile Arg 215 Ser Thr Giu Le u Phe 295 Ser Pro Asp Asp Arg Gi y Arg 120 Ar g Ile Ser Leu Phe 200 Asp Al a Gi u Arq Giu 280 Val1 Tyr Lys Thr Ile 360 Ala Ser 105 Met Arg Asp Tyr Met 185 Al a His Thr Pro Leu 265 Ala Se r Tyr Pro Thr 345 Arg His 90 Trp Gly Phe Gly Leu 170 ValI Gly Al a Asn Asn 250 Ile ValI Glu Gin Asp 330 Gly Ser Trp Asn Lys Phe Arg His 155 Gin Giu As p Giu Le u 235 Leu Le u Thr Gin Ala 315 Val1 As n Ph e Asp Ser Tyr Thr Gin Arg Tyr Al a Arg 140 Thr Lys Leu Trp Al a 220 Val Arg Cys Ser Al a 300 Leu Leu Glu Gly Gi y Pro Trp 125 Pro Ala Lys Thr Tyr 205 His Gin Met Ser Ala 285 Asp Leu His Ala Leu 365 ValI Gi y 110 Tyr Asp Phe Asn Gly 190 Val1 Gly Le u Phe Pro 270 Cys Gin diii Thr Leu 350 Asn Lys T yr Leu Leu Met Ile 175 Pro diii Tyr Ile As n 255 T yr Tyr Phe Ala Lys 335 Gly Tyr Val1 His Met Arg Gly 160 Lys Ile Ser Ile Pro 240 Se r Ph e Arg Al a Gly 320 Tyr Val diii Ile Ser Leu Met Ile Aia Lys Gly Asn Leu Ile His Giu Leu Asn Ala Leu Thr Asp Arg Tyr Arg Thr Val Ser Phe Lys Leu Thr Leu Asp Lys 385 390 395 400 Trp Asn Gin Arg Ser Trp Arg Arg Arg Tyr Val Asp Asn Val Met Arg 405 410 415 Leu Thr Ser Ala Leu Gin 420 <210> 79 <211> 1452 <212> DNA <213> Corynebacterium giutamricurn <220> <221> <222> <223> C DS (101) (14 29) RXN0 0819 <400> 79 gatgaqgttc gtccgggaat cctcaaagac aatgcggtga aggtacttgg cctagccgct agcactgago gcggatctca agcagaaaag gtcgtgcaac atg cgt gat ccc att Met Arq Asp Pro Ile 1 caa ggt gct gtt att cct tot gat ctt Gin Gly Ala Val Ile Pro Ser Asp Leu ggt ttc gca Gly Phe Ala- acc gaa gc Thr Glu Ala gaa gag gtg Glu Giu Vai cgc gca gtt ott Arg Ala Val Leu Ctg Leu gaa aoc cgc agg Glu Thr Arg Arg gaa gtt oto Giu Val Leu gtg ctt gag Val Leu Glu goa gtc ttc Ala Val Phe 211 259 aag oct tat att Lys Pro Tyr Ile gag goc tgg gat Glu Ala Trp Asp ccc gat Pro Asp gag atc gtg oag Glu Ile Val Gin otc caa gat ctg Leu Gin Asp Leu caa Gin ttg ott gat cog Leu Leu Asp Pro Oct Pro goa ctt cqg gaa Ala Leu Arg Giu gca Ala ggg gag tog gtt Gly Giu Ser Val gao att tto aot Asp Ile Phe Thr ttc cgc aat ttt Phe Arg Asn Phe Cc gcg CgC tgt Leu Ala Arg Cys atc aat gtt Ile Asn Val tao aac goa Tyr Asn Ala too cog gag Ser Pro Giu 120 gto aag qqo Val Lys Gly tot Ser 105 got ggt oto ttc Ala Gly Leu Phe cga Arg 110 aog gcc tgo atg Thr Ala Cys Met ggt acc tat Giy Thr Tyr 100 gtt ggt ggc Vai Gly Gly 115 tot ggt gag Ser Gly Giu 403 451 499 cag gog cag oga Gin Ala Gin Arg gat gcg cag atc Asp Ala Gin Ile gtt ttt goa ctg acg gaa Val Phe Ala Leu Thr Glu Oct gat oat ggo tot gat ato Pro Asp His Gly Ser Asp Ile 140 145 gca Ala 150 ggt ggt ctg gca Gly Gly Leu Ala ac Thr 155 acg gcc act aag Thr Ala Thr Lys ga c Asp 160 gca gac acc ggc Ala Asp Thr Gly gag Gi u 165 tgg att atc aat Trp Ile Ile Asn gaa aaa cgg tgg Giu Lys Arg Trp ggt ggt gct tcc Gly Gly Ala Ser act got Thr Ala 180 gat ttg atc Asp Leu Ile tgo ttc ctc Cys Phe Leu 200 acc ttc gcc agg Thr Phe Ala Arg aca gcc gat aac Thr Ala Asp Asn cag gtg aaa Gin Val Lys 195 gag att att Giu Ile Ile gtg gca cct cag Val Ala Pro Gin gag ggc gtg tcc Giu Gly Val Ser gat ogc Asp Arg 215 aaa gcc tca ctg Lys Ala Ser Leu cgc Arg 220 atc atg caa aat Ile Met Gin Asn gca Ala 225 cac att acc tat His Ile Thr Tyr aat gtc cgg gtg Asn Val Arq Val ggg gat gcg cgg Gly Asp Ala Arg ct g Le u 240 cac aac ato aat His Asn Ile Asn ttc aag gat gtt Phe Lys Asp Val tog Ser 250 gaa tgo otg cgc Glu Cys Leu Arg atg cgt too gat Met Arg Ser Asp gtg gog Vai Ala 260 tgg atg gog Trp met Ala tat gtg ogo Tyr Val Arg 280 ggt gog cag gca Gly Ala Gln Ala ggt Gly 270 gcc tat gaa goa Ala Tyr Glu Ala goc gtg aag Ala Val Lys 275 gqg tto cag Gly Phe Gin 931 979 ago agg gaa cag Ser Arg Glu Gin ttt Phe 285 ggc ogt oog ato Gly Arg Pro Ile ttg att Leu Ile 295 oag gaa aag otc Gin Giu Lys Leu cto atg ctg ggo Leu Met Leu Giy aat As n 305 cto aog gog tog Leu Thr Ala Ser otg Leu 310 ggo atg atg gto Gly Met Met Val aaa Lys 315 cto aco gat cag Leu Thr Asp Gin oag Gin 320 oag gog gga att Gin Ala Gly Ile 1027 1075 1123 aaa gag gaa aao Lys Giu Giu Asn gog otg gcg aaa Ala Leu Ala Lys ttt aco tog oto Phe Thr Ser Leu aaa ott Lys Leu 340 ogg gag aco Arg Giu Thr att ttg gao Ile Leu Asp 360 got Al a 345 agt tgg gog ogg Ser Trp Ala Arg gaa Giu 350 ato tgo gga ggo Ile Cys Gly Gly aao ggo ato Asn Gly Ile 355 gaa goc gto Giu Ala Val 1171 1219 aao gat gtt gc Asn'Asp Val Ala tto oat goc gat Phe His Ala Asp tat toa Tyr Ser 375 tat gaa go aco Tyr Glu Gly Thr gaa ato aat goa Gu Ile Asn Ala ctc Leu 385 ato gtt ggn ogn Ile Val Gly Arg 1267 ncc att ctg ggn cnt ctn ttc ttt tta tat tat nac nct ttt gag gag 1315 Xaa Ile Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr Xaa Xaa Phe Giu Giu 390. 395 400 405 gat ctt cat gac tac ttc cac cac ccc aaa cca tcg ttt ctt tcg aag 1363 Asp Leu His Asp Tyr Phe His His Pro Lys Pro Ser Phe Leu Ser Lys 410 415 420 acg cac caa ccc tca ccg gcc agg acc tgg gct ttt cgc agt ggc gca 1411 Thr His Gin Pro Ser Pro Ala Arg Thr Trp Ala Phe Arg Ser Gly Ala 425 430 435 ctg tca ccc agg aga tgg tgaacacctt ggcggacgca act 1452 Leu Ser Pro Arg Arg Trp 440 <210> (211> 443 (212> PRT <213> Corynebacterium giutamicum <400> Met Arg Asp Pro Ile Gin Gly Ala Val Ile Pro Ser Asp Leu Phe Gly 1 5 10 Phe Ala Glu Val Leu Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr 25 Arg Arg Val Leu Giu Glu Glu Val Lys Pro Tyr Ile Asn Giu Ala Trp 40 Asp Lys Ala Val Phe Pro Asp Giu Ile Val Gin Pro Leu Gin Asp Leu 55 Gin Leu Leu Asp Pro Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg 70 75 Asp Ile Phe Thr Gly Phe Arg Asn Phe Glu Leu Ala Arg Gys Asp Ile 90 Asn Val Gly Thr Tyr Tyr Asn Ala Ser Ala Gly Leu Phe Arg Thr Ala 100 105 110 Cys Met Val Gly Gly Ser Pro Glu Gin Ala Gin Arg Leu Asp Ala Gin 115 120 125 Ile Lys Ser Gly Giu Val Lys Gly Val Phe Ala Leu Thr Giu Pro Asp 130 135 140 His Giy Ser Asp Ile Ala Gly Gly Leu Ala Thr Thr Ala Thr Lys Asp 145 150 155 160 Ala Asp Thr Gly Glu Trp Ile Ile Aso Gly Glu Lys Arg Trp Ile Gly 165 170 175 Gly Ala Ser Thr Ala Asp Leu Ile Ala Thr Phe Ala Arg Asp Thr Ala 180 185 190 Asp Asn Gin Val Lys Cys Phe Leu Val Ala Pro Gin Ala Glu Gly Val 195 200 205 Ser Met Giu Ile Ile Asp Arg Lys Ala Ser Leu Arg Ile Met Gin Asn 210 215 220 Ala His Ile Thr Tyr Asn Asn Val Arg Vai Ser Gly Asp Ala Arg Leu 225 230 235 240 His Asn Ile Asn Ser Phe Lys Asp Vai Ser Glu Cys Leu Arg Arg Met 245 250 255 Arg Ser Asp Val Ala Trp Met Ala Val Gly Ala Gin Ala Gly Ala Tyr 260 265 270 Glu Ala Ala Val Lys Tyr Val Arq Ser Arg Glu Gin Phe Gly Arg Pro 275 280 285 Ile Ala Gly Phe Gin Leu Ile Gin Giu Lys Leu Ala Leu Met Leu Gly 290 295 300 Asn Leu Thr Ala Ser Leu Gly Met Met Val Lys Leu Thr Asp Gin Gin 305 310 315 320 Gin Ala Gly Ile Phe Lys Glu Giu Asn Ser Ala Leu Ala Lys Met Phe 325 330 335 Thr Ser Leu Lys Leu Arq Glu Thr Ala Ser Trp Ala Arg Glu Ile Cys 340 345 350 Gly Gly Asn Gly Ile Ile Leu Asp Asn Asp Val Ala Arg Phe His Ala 355 360 365 Asp Ala Glu Ala Val Tyr Ser Tyr Giu Gly Thr His Glu Ile Asn Ala 370 375 380 Leu Ile Val Gly Arg Xaa Ile Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr 385 390 395 400 Xaa Xaa Phe Glu Glu Asp Leu His Asp Tyr Phe His His Pro Lys Pro 405 410 415 Ser Phe Leu Ser Lys Thr His Gin Pro Ser Pro Ala Arg Thr Trp Ala 420 425 430 Phe Arg Ser Gly Ala Leu Ser Pro Arg Arg Trp 435 440 <210> 81 <211> 1030 <212> DNA <213> Corynebacterium glutainicum <220> <221> CDS <222> (18)..(1007) <223> FRXA00819 <400> 81 tcttccqaac qgcctgcatg gtt gqt ggc tcc ccg gag cag gcg cag cga ttg 53 Met Val Giy Gly Ser Pro Glu Gin Ala Gin Arg Leu 1 gat gcg cag Asp Ala Gin ato aaa tct ggt Ile Lys Ser Gly gtc aag ggc gtt Val Lys Gly Val ttt Phe goa ctg acg Ala Leu Thr gaa cct Giu Pro gat cat ggc tct Asp His Gly Ser ga t Asp atc gca ggt ggt Ile Ala Gly Gly gca acc acg gcc Ala Thr Thr Ala aag gac gca gac Lys Asp Ala Asp ggc gag tgg att Gly Giu Trp Ile atc Ile aat ggt gaa aaa Asn Gly Glu Lys tgg ato ggt ggt Trp Ile Gly Gly too act gct gat Ser Thr Ala Asp atc got aco ttc Ile Ala Thr Phe gcc agg Ala Arg gat aca gcc Asp Thr Ala gag ggc gtg Glu Gly Val gat Asp aac cag gtg aaa Asn Gin Val Lys ttc: ctc gtg gca Phe Leu Val Ala oct cag gca Pro Gin Ala ctg cgc ato Leu Arg Ile too atg gag att Ser Met Glu Ile gat ogo aaa gc Asp Arg Lys Ala toa Se r 105 atg oaa Met Gin 110 aat gca cao att Asn Ala His Ile tat aao aat gto Tyr Asn Asn Val gtg tot ggg gat Val Ser Gly Asp gog Ala 125 ogo Arg cgg otg cac aao Arg Leu His Asn ogt atg ogt too Arg Met Arg Ser 145 aat tot ttc aag Asn Ser Phe Lys gat Asp 135 gtt tog gaa tgo Val Ser Glu Cys ot 9 Leu 140 gat gtg gog tgg Asp Val Ala Trp gog gtc ggt gog Ala Val Gly Ala cag gca Gin Ala 155 ggt goc tat Gly Ala Tyr ggc ogt ocg Gly Arg Pro 175 gaa Glu 160 gca goc gtg aaq Ala Ala Val Lys gtg ogo ago agg Val Arg Ser Arg gaa cag ttt Glu Gin The 170 cto gcg oto Leu Ala Leu ato gcg ggg tto Ile Ala Gly Phe ttg att oag gaa Leu Ile Gin Giu aag Lys 185 atg otg Met Leu 190 ggo aat oto aog Gly Asn Leu Thr gog Al a 195 tog ctg ggo atg Ser Leu Gly Met gto aaa oto aco Val Lys Leu Thr gat Asp 205 oag cag oag gog Gin Gin Gin Ala gga Gly 210 att tto aaa gag Ile Phe Lys Giu gaa Glu 215 aac too gog otg Asn Ser Ala Leu gcg Al a 220 aaa atg ttt aco Lys Met Phe Thr oto aaa ott ogg Leu Lys Leu Arg acc got agt tgg Thr Ala Ser Trp gcg ogg Ala Arg 235 gaa ato tgc Glu Ile Cys gga Gly 240 ggc aao ggo ato Gly Asn Gly Ile ttg gac aao gat Leu Asp Asn Asp gtt goc ogg Val Ala Arq 250 ttc cat gcc gat gca gaa gcc gtc tat tca tat gaa ggc acc cac gaa 821 Phe His Ala Asp Ala Glu Ala Val Tyr Ser Tyr Giu Gly Thr His Giu 255 260 265 atc aat gca ctc atc gtt ggn cgn ncc att ctg ggn cnt ctn ttc ttt 869 Ile Asn Ala Leu Ile Val Gly Arg Xaa Ile Leu Gly Xaa Leu Phe Phe 270 275 280 tta tat tat nac nct ttt gag gag gat ctt cat gac tac ttc cac cac 917 L.eu Tyr Tyr Xaa Xaa Phe Glu Giu Asp Leu His Asp Tyr Phe His His 285 290 295 300 ccc aaa cca tcg ttt ctt tcg aag acg cac caa ccc tca ccg gcc agq 965 Pro Lys Pro Ser Phe Leu Ser Lys Thr His Gin Pro Ser Pro Ala Arg 305 310 315 acc tgg gct ttt cgc agt ggc gca ctg tca ccc agg aga tgg 1007 Thr Trp Ala Phe Arg Ser Gly Ala Leu Ser Pro Arg Arg Trp 320 325 330 tgaacacctt cgcggacgca act 1030 <210> 82 <211> 330 <212> PRT <213> Corynebacteriun glutamicum <400> 82 Met Val Giy Gly Ser Pro Giu Gin Ala Gin Arg Leu Asp Ala Gin Ile 1 5 10 Lys Ser Gly Giu Val Lys Gly Val Phe Ala Leu Thr Giu Pro Asp His 25 Giy Ser Asp Ile Ala Gly Gly Leu Ala Thr Thr Ala Thr Lys Asp Ala 40 Asp Thr Gly Giu Trp Ilie Ile Asn Gly Giu Lys Arg Trp Ile Gly Gly 55 Ala Ser Thr Ala Asp Leu Ile Ala Thr Phe Ala Arg Asp Thr Ala Asp 70 75 Asn Gin Val Lys Cys Phe Leu Val Ala Pro Gin Ala Giu Gly Val Ser 90 Met Glu Ile Ile Asp Arg Lys Ala Ser Leu Arg Ile Met Gin Asn Ala 100 105 110 His Ile Thr Tyr Asn Asn Val Arg Val Ser Gly Asp Ala Arg Leu His 115 120 125 Asn Ile Asn Ser Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met Arg 130 135 140 Ser Asp Val Ala Trp Met Ala Vai Gly Ala Gin Ala Gly Ala Tyr Giu 145 150 155 160 Ala Ala Val Lys Tyr Val Arg Ser Arg Giu Gin Phe Gly Arq Pro Ile Al a Le u Ala Ser 225 Gly Al a Ile Xaa Phe 305 Arg Gly Thr Gi y 210 Le u Asn Giu Val1 Ph e 290 Le u Se r Phe Ala 195 Ile Lys Gly Ala Gly 275 Glu Ser Gly Gin 180 Ser Phe Leu Ile Val1 260 Arg Giu Lys Ala Le u Le u Lys Arg Ile 245 Tyr Xaa Asp Thr Le u 325 Ile Giy Glu Giu 230 Le u Ser Ile Le u His 310 Ser Gin Met Giu 215 Thr Asp Tyr Leu His 295 Gin Pro Glu Met 200 Asn Ala As n Glu Giy 280 Asp Pro Ar g Lys 185 Val Ser Ser Asp Gi y 265 Xaa Tyr Ser Arq Le u Lys Al a Trp Val1 250 Thr Le u Phe Pro Trp 330 Ala Le u Le u Ala 235 Al a His Phe His Al a 315 Leu Thr Ala 220 Arg Arg Giu Phe His 300 Arg Met Asp 205 Lys Giu Phe Ile Leu 285 Pro Thr Leu 190 Gin Met Ile His As n 270 Tyr Lys Trp Gly Gin Phe cys Ala 255 Ala T yr Pro Ala Asn Gin Tb r Gi y 240 Asp Le u Xaa Ser Phe 320 <210> 83 <211> 391 <212> DNA <213> Corynebacterium glutamioum <22 0> <221> CDS <222> (101)..(391) <223> FRXA01766 <400> 83 qatgaggttc gtcogggaat octcaaagac aatgcggtga agcaotgagc goggatotoa agcagaaaag qtogtgoaao caa ggt got gtt att cot tct gat ott ttt ggt Gin Gly Ala Val Ile Pro Ser Asp Leu Phe Gly 15 acc gaa gcc gaa cgc goa gtt ctt otg gaa aco Thr Glu Ala Glu Arg Ala Val Leu Leu Giu Thr 30 gaa gag gtg aag oct tat att aat gag gcc tgg Giu Giu Val Lys Pro Tyr Ile Asn Glu Ala Trp 45 aggtaottgg cotagoogot atg cqt gat ooc att Met Arg Asp Pro Ile 1 tto goa gaa gtt oto Phe Ala Giu Val Leu ogo agg gtg ott gag Arg Arg Val Leu Glu gat aag goa gtc tto Asp Lys Ala Val Phe ccc gat gag atc gtg cag ccc ctc caa gat ctg caa ttg ctt gat ccg 307 Pro Asp Giu Ile Val Gin Pro Leu Gin Asp Leu Gin Leu Leu Asp Pro 60 cct gca ctt cgg gaa gca ggg gag tcg gtt cga gac att ttc act ggt 355 Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg Asp Ile Phe Thr Gly 75 80 ttc cgc aat ttt gaa ctc gcg cgc tgt gac atc aat 391 Phe Arg Asn Phe Giu Leu Ala Arg Gys Asp Ile Asn <210> 84 <211> 97 (212> PRT <213> Corynebacterium glutamicum <400> 84 Met Arg Asp Pro Ile Gin Gly Ala Val Ile Pro Ser Asp Leu Phe Gly 1 5 10 Phe Ala Giu Val Leu Thr Giu Ala Giu Arg Ala Val Leu Leu Giu Thr 25 Arg Arg Val Leu Giu Giu Giu Val Lys Pro Tyr Ile Asn Giu Ala Trp 40 Asp Lys Ala Val Phe Pro Asp Giu Ile Val Gin Pro Leu Gin Asp Leu 55 Gin Leu Leu Asp Pro Pro Ala Leu Arg Giu Ala Gly Giu Ser Val Arg 70 75 Asp Ile Phe Thr Gly Phe Arg Asn Phe Giu Leu Ala Arg Cys Asp Ile 90 As n <210> <211> 1659 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1636) <223> RXN0i762 <400> tggaqtgatg aattttccta tagaacgttt tttaaacqat tgacttttta aacgtttacg cttttaatga cttcaaacgt gatctaaagc acaaaggaga atg aaa qtq aac ctc 115 Met Lys Val Asn Leu 1 gga ata gga agc tac cca cga cgc agg gca act gtt cga cca gag tcc 163 Gly Ile Gly Ser Tyr Pro Arg Arg Arg Ala Thr Val Arg Pro Giu Ser act gca atc Thr Ala Ile aaa cga gtc Lys Arq Val ga a Giu ttc gaa ggc aco Phe Giu Gly Thr ago Ser 30 atc acc tac gga Ile Thr Tyr Gly gaa ttc agc Giu Phe Ser ggc gtt gcg Gly Vai Ala 211 259 aat cgg ctt gga Asn Arg Leu Giy gct ctt ota gac Ala Leu Leu Asp cac caa His Gin gat cga gta gct Asp Arg Val Ala gtc gga ttc aac Val Gly Phe Asn cac His oct *gcc ctg ota Pro Ala Leu Leu gtg ttc ttt tca Val Phe Phe Ser acg Thr aac ctc att ggg Asn Leu Ile Gly aca ccc gtg ctt Thr Pro Val Leu aac cct ogo cta Asn Pro Arg Leu gca aac gaa ato Ala Asn Giu Ile tac ato ato caa Tyr Ile Ile Gin gao agc Asp Ser 100 ggt gcg ago Gly Ala Ser tac otc caa Tyr Leu Gin 120 atc Ile 105 gtg ttt tao gga Val Phe Tyr Gly atc Ile 110 gac otc ato gag Asp Leu Ile Giu cac goc act His Ala Thr 115 gtt gaa ggc Val Giu Gly gaa oto cat oca Giu Leu his Pro ato ato atg gtg Ile Ile Met Val gat gag Asp Glu 135 ggt oca ggt ttg Gly Pro Gly Leu oga aaa gog ott Arg Lys Ala Leu att Ile 145 gaa gog gog ago Glu Ala Ala Ser gao Asp 150 goc gao ato gao Ala Asp Ile Asp gaa gto aqo gat Giu Val Ser Asp gao otg gtg otg Asp Leu Val Leu ctc Le u 165 atg tao aco too Met Tyr Thr Ser gga Gly 170 aco act ggc ogo Thr Thr Giy Arg o oa Pro 175 aag ggo goc atg Lys Giy Ala Met tta too Leu Ser 180 oao oga aac His Arg Asn att gaa oaa Ile Glu Gin 200 ot 0 Leu 185 tto ttt aac tao Phe Phe Asn Tyr ttc Phe 190 aat goo otg oto Asn Ala Leu Leu ago cag gaa Ser Gin Giu 195 tto cac ato Phe His Ile ggo gog gta ott Gly Ala Val Leu too aot gog oogj Ser Thr Ala Pro gog ggo Ala Gly 215 oto aao atg aco Leu Asn Met Thr aco Thr 220 ato cog gtg atg ile Pro Val Met atg Met 225 aag ggo gga aag Lys Gly Gly Lys gtg Val1 230 ato ato oao ogo Ile Ile His Arg tto ogg gca gag Phe Arg Ala Giu gto oto gao gaa Val Leu Asp Giu gaa ogo too aag Giu Arg Ser Lys gta Val1 250 too gaa too tto Ser Giu Ser Phe at g Met 255 gtg oca gog atg Val Pro Ala Met ato gao Ile Asp 260 atg ttg tc Met Leu Ser cgc gcc ate Arg Ala Ile 28D cac cca tca ttt His Pro Ser Phe gc Ala 270 gaa ego gac ctt Giu Arg Asp Leu tct tcc ctt Ser Ser Leu 275 gcg ctg cga Ala Leu Arg atg gtg ggc ggc Met Val Gly Gly ccc ctt agc gaa Pro Leu Ser Glu atc tgg Ile Trp 295 caa gga cgc gac Gin Gly Arg Asp aaa att gtc eaa Lys Ile Val Gin ggc Gly 305 ttc ggc atg aca Phe Gly Met Thr ga a Glu 310 acc gca cog ggc Thr Ala Pro Gly tgt atc ctc gag Cys Ile Leu Giu aca. gac aca agc Thr Asp Thr Ser 1027 1075 1123 eac ott gga acc His Leu Giy Thr gca Al a 330 ggt ega gcc cac Gly Arg Ala His ttc ace gac ate Phe Thr Asp Ile aaa. eta Lys Leu 340 gtg gao ceg Val Asp Pro gtt etc atc Val Leu Ile 360 ace ggc gaa gaa Thr Gly Giu Giu gte Val1 350 ccc ace gga gag Pro Thr Gly Giu gcc ggc gaa Ala Gly Glu 355 aac cga. cca Asn Arg Pro 1171 1219 cgc gga cca eat Arg Giy Pro His atg ace gga, tao Met Thr Gly Tyr gaa gac Glu Asp 375 acc goc agc gca Thr Ala Ser Ala caa. aat ggc tgg Gin Asn Giy Trp cac too gga gat His Ser Giy Asp goo atc aaa gat Ala Ile Lys Asp gao ggc tao tao Asp Gly Tyr Tyr ace Thr 400 ate aaa. gao ego Ile Lys Asp Arg ate Ile 405 1267 1315 1363 aaa gao atg tao Lys Asp Met Tyr ate Ile 410 tco ggc ggc gaa Ser Gly Gly Giu att tao eec gea Ile Tyr Pro Ala gaa gtc Glu Val 420 gaa. caa gca Giu Gin Ala gga gte ccc Gly Val Pro 440 cag gaa etg gaa Gin Giu Leu Giu gte ott gat gee Val Leu Asp Ala gca gte ate Ala Val Ile 435 ttt gte tee Phe Val Ser gat gaa oga tgg Asp Giu Arg Trp gaa act gge ate Giu Thr Gly Ile gee Ala 450 ate oga Ile Arg 455 gaa ago tao otg Giu Ser Tyr Leu ace Thr 460 aae oca eca. ace Asn Pro Pro Thr cog gaa eta. oga Pro Giu Leu Arg 1411 1459 1507 1555 1603 eta eta ggo agt Leu Leu Gly Ser eta. gee aga tae Leu Ala Arg Tyr aaa. Lys 480 ctt eca ega gaa Leu Pro Arg Giu ate Ile 485 cac ato ate gaa His Ile Ile Giu gaa Glu 490 etc ccc ego aac Leu Pro Arg Asn gee aca ggc aaa ate caa aag Ala Thr Gly Lys Ile Gin Lys 495 500 aac atc ctg ccga gac ttc acc atc ccc gtt tca taaacccccc aacgtcactt 1656 Asn Ile Leu Arg Asp Phe Thr Ile Pro Val Ser 505 510 tga 1659 <210> 86 <211> 512 (212> PRT <213> Corynebacterium glutamicum <400> 86 Met Lys Val Asn Leu Gly Ile Giy Ser Tyr Pro Arg Arg Arg Ala Thr 1 5 10 Val Arg Pro Giu Ser Thr Ala Ile Glu Phe Glu Gly Thr Ser Ile Thr 25 Tyr Gly Giu Phe Ser Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu 40 Asp Leu Giy Val Ala His Gin Asp Arg Val Ala Tyr Val Giy Phe Asn 55 His Pro Ala Leu Leu Glu Val Phe Phe Ser Thr Asn Leu Ile Gly Ala 70 75 Thr Pro Vai Leu Val Asn Pro Arg Leu Ser Ala Asn Glu Ile Asp Tyr 90 Ile Ile Gin Asp Ser Gly Ala Ser Ile Val Phe Tyr Gly Ile Asp Leu 100 105 110 Ile Giu His Ala Thr Tyr Leu Gin Giu Leu His Pro Giu Ile Ile Met 115 120 125 Val Ala Vai Giu Gly Asp Giu Gly Pro Gly Leu Arg Arg Lys Ala Leu 130 135 140 Ile Giu Ala Ala Ser Asp Ala Asp Ile Asp Leu Giu Val Ser Asp Asp 145 150 155 160 Asp Leu Val Leu Leu Met Tyr Thr Ser Gly Thr Thr Gly Arq Pro Lys 165 170 175 Gly Ala Met Leu Ser His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala 180 185 190 Leu Leu Ser Gin Giu Ile Giu Gin Giy Ala Vai Leu Leu Ser Thr Ala 195 200 205 Pro Leu Phe His Ile Ala Gly Leu Asn Met Thr Thr Ile Pro Val Met 210 215 220 Met Lys Giy Gly Lys Val Ile Ile His Arg Giu Phe Arg Ala Giu His 225 230 235 240 Vai Leu Asp Giu Ile Giu Arg Ser Lys Val Ser Giu Ser Phe Met Val 245 250 255 Pro As p GJlu Gly 305 Thr Thr Gi y Tyr Tyr 385 Ile Tyr Asp Ile Gly 465 Le u Gly Al a Le u Arg 290 Phe Asp Asp Glu Trp 370 His Lys Pro Al a Al a 450 Pro Pro Lys Met Ser 275 Ala Gly Thr Ile Al a 355 As n Ser Asp Ala Al a 435 Phe Glu Arg Ile Asp Met Leu Leu Arq Th r Thr 325 Le u Glu Pro Asp Ile 405 Val1 Ile Ser Arq Ile 485 Lys Arg Ile Glu 310 His Val1 Val1 Gi u Ile 390 Lys Glu Gly Ile Glu 470 His Asn Ala T rp 295 Thr Le u Asp Leu Asp 375 Al a Asp Gin Val Arg 455 Leu Ile Ile Asn 265 Met Gi y Pro Thr Lys 345 Arg Al a Lys Tyr Leu 425 Asp Ser Gly Giu Arg 505 Pro Gi y Asp Al a 315 Gly Gi y Pro Al a Glu 395 Ser Glu Arg Le u Val1 475 Leu Phe Ser Gly Val1 300 Cys Arg Glu His Leu 380 Asp Gly Le u Trp Thr 460 Leu Pro Thr Glu Leu Val1 Glu Phe 335 Pro Thr Gly Tyr As n 415 Val1 Thr Pro Tyr Ala 495 Val1 Arg Se r Gin Ala 320 Ph e Thr Gly Trp Thr 400 Ile Le u Gly Thr Lys 480 Thr Se r (210> 87 <211> 1372 <212> DNA <213> Corynebacterium giutamicum <220> (221> CDS <222> (1363) <223> FRXA01762 <400> 87 tggagtgatg aattttccta iagaacgttt tttaaacgat cttttaatga cttcaaacgt gatctaaagc acaaaggaga tgacttttta aacgtttacg atg Met 1 aaa gig aac Lys Val Asn gga ata gga agc Gly Ile Gly Ser tac Tyr cca cga cgc agg Pro Arg Arg Arg gca Al a 15 act gtt cga cca Thr Val Arg Pro gag tcc Glu Ser act gca aic Thr Ala Ile aaa cga gtc Lys Arg Val tic gaa ggc acc Phe Glu Gly Thr atc acc tac gqa Ile Thr Tyr Gly gaa tic agc Glu Phe Ser ggc gti gcg Gly Val Ala aai cgg cti gga Asn Arg Leu Gly cat His 45 gci cii cta gac Ala Leu Leu Asp ctc Le u cac caa His Gin gat cga gia gct Asp Arg Val Ala gtc gga tic aac Val Gly Phe Asn cci gcc cig cia Pro Ala Leu Leu ga a Glu gig tic tii ica Val Phe Phe Ser a cg Thr 75 aac cic att ggg Asn Leu Ile Gly g ca Al a 80 aca ccc gtg ct Thr Pro Val Leu gt i Val1 aac cci cgc cia Asn Pro Arg Leu gca aac gaa atc Ala Asn Glu Ile tac aic aic caa Tyr Ile Ile Gin gac agc Asp Ser 100 ggt gcg agc Gly Ala Ser iac cic caa Tyr Leu Gin 120 gtg ttt tac gga Val Phe Tyr Gly gac ctc aic gag Asp Leu Ile Glu cac gcc act His Ala Thr 115 gti qaa ggc Val Giu Gly gaa cic cat cca Glu Leu His Pro gag Gi u 125 aic aic aig gig Ile Ile Met Val gai gag Asp Giu 135 ggi cca ggt tig Gly Pro Gly Leu cga aaa gcg cii Arg Lys Ala Leu gaa gcg gcg agc Giu Ala Ala Ser gcc gac aic gac Aia Asp Ile Asp cia Le u 155 gaa gic agc gat Glu Val Ser Asp ga t Asp 160 gac cig gig cig Asp Leu Val Leu cic Leu 165 aig tac acc icc Met Tyr Thr Ser acc act ggc cgc Thr Thr Gly Arg aag ggc gcc aig Lys Gly Ala Met tia icc Leu Ser 180 cac cga aac His Arg Asn ati gaa caa Ile Giu Gin 200 cic Le u 185 tic ttt aac tac Phe Phe Asn Tyr tc Phe 190 aai gcc cig cic Asn Ala Leu Leu agc cag gaa Ser Gin Giu 195 tic cac aic Phe His Ile ggc gcg gia cii Gly Ala Val Leu icc act gcg ccg Ser Thr Ala Pro gcg ggc cic aac aig acc acc aic ccg gtg aig atg aag ggc gga aag Ala Gly Leu Asn Met Thr lePrVa Me Ly GyGyLy Ile Pro Val Met Lys Gly Gly Ly8 atc atc cac cgc Ile Ile His Arg ga a Glu 235 ttc cgg gca gag Phe Arg Ala Glu cac His 240 gte ctc gac gaa Val Leu Asp Giu atc Ile 245 qaa cge tcc aag Giu Arg Ser Lys tcc gaa tee ttc Ser Giu Ser Phe gtg cca gcg atg Val Pro Ala Met ate gac Ile Asp 260 atg ttg tee Met Leu Ser cgc gee ate Arg Ala Ile 280 aac Asn 265 cac cca tca ttt His Pro Ser Phe gee Al a 270 gaa cgc gac ctt Glu Arg Asp Leu tct tee ctt Ser Ser Leu 275 gcg ctg cga Ala Leu Arg 931 979 atg gtg ggc ggc Met Val Gly Gly ccc ctt age gaa Pro Leu Ser Giu cgt Arg 290 atc tgg Ile Trp 295 caa gga egc gac Gin Gly Arg Asp g ta Val1 300 aaa att gte caa Lys Ile Val Gin ggc ttc ggc atg Giy Phe Giy Met 305 aca gac aca age Thr Asp Thr Ser a ca Thr aca Thr 325 acc gca ccg gqc Thr Ala Pro Giy gcc Ala 315 tgt ate ctc gag Cys Ile Leu Glu 1027 1075 1123 cac ctt gga acc, His Leu Giy Thr ggt ega gcc cac Gly Arg Ala His ttc Phe 335 ttc ace gac atc Phe Thr Asp le aaa eta Lys Leu 340 gtg gac ccg Val Asp Pro gtt etc atc Val Leu Ile 360 ace ggc gaa gaa Thr Giy Giu Glu ccc acc gga gag Pro Thr Gly Glu gcc ggc gaa. Ala Gly Glu 355 aac ega cca Asn Arg Pro 1171 1219 ege gga cca eat Arg Gly Pro His gtg Val1 365 atg ace gga tac Met Thr Gly Tyr t gg Trp 370 gaa gac Giu Asp 375 ace gce age gea Thr Ala Ser Ala eaa aat gge tgg Gin Asn Gly Trp cac tee gga gat His Ser Gly Asp ate Ile 390 gee ate aaa gat Ala Ile Lys Asp gaa Gi u 395 gac gge tac tac Asp Gly Tyr Tyr ate asa gac ege Ile Lys Asp Arg ate Ile 405 1267 1315 1363 aaa gac atg tac Lys Asp Met Tyr tee ggc ggc gaa Ser Gly Gly Giu aae Asn 415 att tac ccc gea Ile Tyr Pro Ala gaa gte Glu Vai 420 taagtaeee <210> 88 <211> 421 (212> PRT <213> Corynebacterium giutamicun (400> 88 Met Lys Val Asn Leu Gly Ile Giy Ser Tyr 1372 Pro Arg Arg Arg Ala Thr 1 Val1 Tyr Asp His Th r Ile Ile Val1 Ile 145 Asp Gly Leu Pro Met 225 Val1 Pro Asp Glu Gly 305 Thr Gi u Ph e Val1 Le u Le u Asp 100 Al a Glu Al a Leu Leu 180 Gin His Gi y Glu Ilie 260 Se r Le u Met Se r 5 Ser Ser Al a Leu Val1 Ser Thr Gly Ser Leu 165 Se r Giu Ile Lys Ile 245 Asp Leu Arg Thr Thr 325 .Thr Lys His Giu 70 Asn Gly T yr Asp Asp 150 Met His Ile Al a Val1 230 Giu Met Arg Ile Giu 310 His Ala Arg Gin Val1 Pro Ala Le u Giu 135 Ala T yr Arg Giu Gly 215 Ile Arg Leu Ala Trp 295 Thr Leu Ile Giu 25 Vai Asn Asp Arg Phe Phe Arg Leu Ser Ile 105 Gin Giu 120 Gly Pro Asp Ile Thr Ser Asn Leu 185 Gin Giy 200 Leu Asn Ile His Ser Lys Ser Asn 265 Ile Met 280 Gin Giy Aia Pro Giy *Thr Giu Le u Al a Th r 75 Ala Phe His Le u Le u 155 Thr Phe Val1 Thr Glu 235 Ser Pro Giy Asp Ala 315 Gi y Giy Gly T yr Asn As n Tyr Pro Arq 140 Giu Thr As n Leu Thr 220 Phe Glu Ser Giy Val1 300 cys Arg Ser Ala Gi y Ile Ile Ile 110 Ile Lys Ser Arq Phe 190 Ser Pro Ala Ph e Aia 270 Pro Ile Le u His Ile Leu Phe Gly Asp Asp Ile Aia Asp Pro 175 Asn Thr Val Giu Met 255 Giu Le u Val Giu Phe 335 Thr Leu As n Al a Tyr Leu Met Leu Asp 160 Lys Ala Aila Met His 240 Val1 Arg Se r Gin Al a 320 Phe Thr Gly Tyr Tyr 385 Ile Tyr Asp Ile L 3, Giu Ala G. 355 Trp Asn A: 370 His Ser G: Lys Asp A] Pro Ala G~ ys ly rg l-y lu Leu Giu Pro Asp Ile 405 Val1 Asp Leu Asp 375 Ala Asp Pro Ile 360 Thr Ile Met Thr Gly Ser Asp Ile 410 Giu Val1 365 Gin Giy Gly Thr Gly Trp Thr 400 Ile 4; <210> 89 <211> 867 <212> DNA <213> Corynebacterium giutamicun <220> <221> CDS <222> (101)..(844) <223> RXA0068i <400> 89 aagggcaagg ttgtcattgt tgatccagat gcgccacgCa tcgaaggacc cgqgecgcac agccatgcgc actcagtagc agcacatggg gtggatacac atg cct agt cca cgc act Thr gaa Glu ctg Leu gat Asp gcc Al a ct t Le u atc Ile gca Al a gcg Al a gcc Aia gcc Aila aac As n act Thr gcc Ala caa Gin ttt Phe g gt Giy g ca Ala ggt Giy caa Gin gag Glu ga a Giu gcc Ala gcg Al a gcC Ala gga Gly acc Thr gtt Val gct Ala ata Ile gct Al a gac Asp gt t Val1 ga t Asp gag Glu tat Tyr qgc Gly cgt Arg 30 gac Asp gt C Val1 ttt Ph e gcg Al a Met 1 ggt Gly gtg Val1 aaa Lys ttq Leu gg C Gly act Thr Ser gca Ala ga t Asp ttq Leu tcc Ser att Ile t ca Ser Pro ttc Phe atc Ile Gly acc Thr gat Asp Ccg Pro 100 gag Giu aaa Lys aat As n qca Ala 150 acc Thr gcg Ala gat Asp agc Ser gaa Giu 230 cag Gin gat Asp ggc Giy gCC Ala 135 cac His a gy Arg gtt ValI a gc Ser ca a Gin 215 gcc Ala ttC Phe att gac Ile Asp 105 ccg tgg Pro Trp 120 cgt gtg Arg Val tgq qgg Trp Ala gtg ctt Val Leu gcg cct Ala Pro 185 gcg gaa Ala Glu 200 ccg aaa Pro Lys gaa tac Glu Tyr atc taac Ile cct qcq gag tgg Pro Ala Giu Trp gat ttg gtc atg gga gtc aat ctc Asp Leu Val Met Gly Val Asn Leu ttg Leu gtC Val1 cac His gct Ala 170 ggg Giy a cq Thr gac Asp atc gtg Val1 aa t Asn tac Tyr 155 aaa Lys ttt Phe tac Tyr atc Ile act a cg Thr Ct t Leu 140 gtg Val1 gag Giu acg Thr ggt Gly gtc Val1 220 ggg cgt Arg 125 tcc Ser qca Al a Ct 9 Le u Ctg Leu gtc Val1 205 ggc Gly caa gtg Val1 qg Ala aaa Lys ggt Gly 175 qaa Glu cgc Arg acc Thr ctc agt Ser act Thr gg t Gly 160 Cgt Arg gcc Al a gga Gi y atg Met atc Ile Cog Pro gtg Val 145 99g Gly ggg Gly aqc Ser toe Ser ttt Phe 225 gtt Val1 ttt Phe 130 ttt Phe gtc Val atc Ile t tq Leu atc Ile 210 Ctt Leu gat Asp 115 ttg Leu t ca Se r att Ile acg Thr qga Gly 195 aag Lys gca Ala ggt Gi y t cc Ser gga Gly gct Ala gtc Val1 180 ctc Leu cgc Arg tcc Ser ggc Gi y ga t Asp tct Se r tta Leu 165 aat As n atg Met gca Ala cca Pro cga Arg 245 451 499 547 595 643 691 739 787 835 867 Ile Thr Gly Gin Thr Leu 235 jtactaa aagttctaag gag (210> (211> 248 (212> PRT <213> Corynebacterium glutamicun <400> Met Pro Ser Pro Arg Thr Val Leu Ile Thr 1 5 10 Gly Arg Ala Phe Ala Glu Cly Phe Ala Ala 25 Val Ala Asp Ile Asn Leu Asp Gly Ala Gin 40 Lys Ala Leu Gly Ala Asp Ala Ala Ala. Phe 55 Leu Glu Ser Thr Glu Ala Leu Ala Ala Gly Ala Ala Gly Gly Gly Asp Arg Ile Thr Val Asp Lys Val Asp Val Thr Ala Glu Phe Gly Gly Thr Met Pro Val1 145 Gly Gly Ser Ser Phe 225 Val1 Arg Arg Gly Phe 130 Phe Val1 Ile Le u Ile 210 Leu Asp Ile Ser Val1 115 Leui Ser Ile Thr Gi y 195 Lys Ala ci y Asp Pro 100 As n Ser Gi y Al a Val1 180 Le u Arg Ser ci y Val1 Phe Le u Asp Ser Le u 165 As n Met Al a Pro Arg 245 Ile Asp Gly Ala 135 His Arg Val Ser Gin 215 Ala Phe Asn Ile Pro 120 Arg Trp Val1 Al a Al a 200 Pro Giu Ile Al a Pro Le u Val1 His Al a 170 Gly Thr Asp Ile Ala Al a ValI Asn T yr 155 Lys Phe Tyr Ile Thr 235 Ile Giu Thr Leu 140 Val1 Giu Thr Gly Val1 220 Gly Tyr Trp Arg 125 Se r Ala Le u Leu Val1 205 Gly Gin Ala Asp 110 Se r Ser Se r Gi y Thr 190 Asp Thr Thr <210> 91 <211> 837 <212> DNA '<213> Corynebacterium giutamicum <220> <221> CDS <222> (814) <223> RXA00802 <400> 91 gccatggtga tcaczaccagt gtgggggctg aggctccaca gcgggcacta agccccgaac gattagtagg cttgggcacc ggt ggc caa gtc ata ctt gtt gtt ggc ggt gca Gly Gly Gin Val Ile Leu Val Val Gly Gly Ala 15 gaa gtt gta aaa ctc tta act gaa gaa ggc gca Glu Val Val Lys Leu Leu Thr Glu Glu Gly Ala 30 tcg aga agc acg ccc tta tct att gac gct tcg cttggaggaa tggattaaac atg gat ctt aaa ctt 115 Met Asp Leu Lys Leu 1 gga act att ggt tct 163 Gly Thr Ile Gly Ser acc gcg gta gcg gcg 211 Thr Ala Val Ala Ala gat gaa gcg tcc gtc 259 Ser Arg Ser Thr Pro Leu Ser Ile Asp Ala Ser Asp Glu Ala Ser Val 45 gog Ala gtt Val1 gat Asp ttt Phe cat His ag t Ser 135 aat Asn ago Ser aat As n t gt Cys ata Ile 215 ggc Gly gt t Val1 gat Asp atg Met ggg Gly 120 act Thr ttg Leu ccg Pro ggt Gly ogo Arg 200 agg Arg att Ile tct Se r cog Pro aag Lys 105 cgc Arg act Th r gog Al a gg a Gly gac Asp 185 og o Ar g oga Arg cag Gin gca Ala act Thr gca Al a gt t Val1 t cg Se r og t Arg 155 gt g Val1 acg Thr cg Pro gca Ala gtg Val1 60 ccc Pro gtg Val1 acc Thr gca Al a 9gg Al a 140 cac His gta Val tgg Trp cat His t ca Ser 220 gaa Glu caa Gin gct Ala ct 0 Leu 9gc Gly got Ala aco Thr oca Pro 175 t cg Ser ctg Leu ott ggt Gi y ctc Le u gaa Gi u aag Lys aac As n otg Le u 145 att Ile got Ala agg Arg aga Arg tog ogc Arg agc Ser ggc Gly atg Met t ca Ser 130 aa t As n aca Thr gag Giu cga Arg tta Leu 210 cgt ctg Leu gog Al a aaa Lys ogt Arg 115 tac Tyr gt o Val1 gt a Val1 q ta Val1 tog Ser 195 ttt Phe gag gat Asp gag Giu gco Al a 100 gag Giu aaa Lys gtg Val1 aat As n aao As n 180 ogt Arg cgg Arg ott ggg Gi y aca Thr atc Ile got Al a aca Thr gtg Val gog Ala 165 ogo Arg ttt Phe tgg Trp ccc 307 355 403 451 499 547 595 643 691 739 787 Leu Ser Ser Arg Glu Leu Pro 225 aag cgt aag cac ccc cgt gtg agg gca taaoggccgt totgttaaag Lys Arg Lys His Pro Arg Val Arg Ala 230 235 att <210> 92 <211> 238 <212> PRT <213> Corynebacteriun glutamicum <400> 92 Met Asp Leu Lys Leu Gly Gly Gin Val Ile Leu Val Val Gly Gly Ala 1 5 10 Gly Thr Ile Gly Ser Glu Val Val Lys Leu Leu Thr Glu Glu Gly Ala 25 Thr Ala Val Ala Ala Ser Arg Ser Thr Pro Leu Ser Ile Asp Ala Ser 40 Asp Glu Ala Ser Vai Arg Ala Gly Ile Asp Gin Vai Ile Ala Glu His 55 Gly Arg Leu Asp Gly Leu Val Val Set Ser Ala Pro Ala Ala Gin Thr 70 75 Leu Ser Ala Giu Thr Ala Asp Asp Pro Asp Thr Val Leu Ala Ala Ile 90 Glu Gly Lys Ala Ile Thr Phe Met Lys Ala Ala Thr Val Ala Leu Glu 100 105 110 Lys Met Arg Glu Ala Giy His Gly Arg Ile Val Ala Leu Ser Gly Met 115 120 125 Asn Ser Tyr Lys Thr Leu Ser Thr Thr Ala Ser Ala Arg Asn Ala Ala 130 135 140 Leu Asn Val Val Val Lys Asn Leu Ala Asp Arg His Ala Gly Thr Gly 145 150 155 160 Ile Thr Val Asn Ala Ile Ser Pro Gly Phe Val Val Ala Giu Pro Asp 165 170 175 Ala Giu Val Asn Arq Ala Asn Gly Asp Thr Thr Trp Arg Arg Ser Arg 180 185 190 Arq Arg Ser Arg Phe Cys Cys Arq Arg Ala Pro His Gin Phe Leu Giu 195 200 205 Arq Leu Phe Arg Trp Asp Ile Arg Arg Arq Ala Ser Ser Phe Leu Ser 210 215 220 Ser Arg Glu Leu Pro Lys Arg Lys His Pro Arg Val Arg Ala 225 230 235 <210> 93 <211> 329 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (306) <223> RXA02133 <400> 93 gaa aac ccc tac att ggc gga gct gga tac aac gca gca aaa ttc ggt 48 Giu Asn Pro Tyr Ile Gly Gly Ala Gly Tyr Asn Ala Ala Lys Phe Gly 1 5 10 gta gca qca ttc aac cgt gtg ctt cgc ttg qaa acc cac cag cag acc 96 Val Ala Ala Phe Asn Arg Val Leu Arg Leu Giu Thr His Gin Gin Thr 25 ott cgc gta tct gag atc gat cca ggt cga qtt gcc acg gaa gaa ttc 144 Leu Arg Val Ser Giu Ile Asp Pro Giy Arg Vai Ala Thr Glu Giu Phe 40 tcc oto gtt cgt ttc ggc gga gat aaa gaa cgc gca gaa gca gtc tat 192 Ser Leu Val Arg Phe Gly Gly Asp Lys Glu Arg Ala Glu Ala Val Tyr 55 gao gac gtc oto aac ctc aco gct gaa gac atc gca gag tot gty cgt 240 Asp Asp Val Leu Asn Leu Thr Ala Glu Asp Ile Ala Glu Ser Val Arg 70 75 tgg gtc gcg ago ott cca aag cao atg aac att gac ogo atg cqjt att 288 Trp Val Ala Ser Leu Pro Lys His Met Asn Ile Asp Arg Met Arg Ile 90 aca cot ogo gat cag gto taaaaooogo aotcttttga aat 329 Thr Pro Arg Asp Gin Vai 100 <210> 94 <211> 102 <212> PRT <213> Corynebacterium giutamicum (400> 94 Glu Asn Pro Tyr Ile Gly Gly Ala Gly Tyr Asn Ala Ala Lys Phe Gly 1 5 10 Val Ala Ala Phe Asn Arg Val Leu Arg Leu Glu Thr His Gin Gin Thr 25 Leu Arg Val Ser Giu Ile Asp Pro Gly Arg Val Ala Thr Glu Giu Phe 40 Ser Leu Val Arg Phe Gly Gly Asp Lys Giu Arg Ala Giu Ala Val Tyr 55 Asp Asp Val Leu Asn Leu Thr Ala Giu Asp Ile Ala Giu Ser Val Arg 70 75 Trp Val Ala Ser beu Pro Lys His Met Asn Ile Asp Arg Met Arg Ile 90 Thr Pro Arg Asp Gin Val 100 <210> <211> 1347 <212> DNA <213> Corynebacterium giutamioum <220> <221> CDS <222> (101)..(1324) <223> RXN01114 <400> ttcggtggaa gatatccgca agctggtgct gccgcagctt ttcgacagat ctctctgcac tctaaattaa ggatcaaaaa ttagaaacgg ctcaagcaat atg aac cct caa Met Asn Pro Gin 1. att gtc atc tgt Ile Val Ile Cys cca ttg cgc acc Pro Leu Arg Thr cca Pro gtt ggt gct tac Val Gly Ala Tyr ggc gga Gly Gly tcc tto aco Ser Phe Thr gcg atc gtt Ala Ile Vai gtc oct gtt gaa Vai Pro Val Glu ttg gcc aco ac Leu Ala Thr Thr gtq atc aac Val Ile Asn gac gat ctg Asp Asp Leu gag gca acc ggo Giu Ala Thr Gly acc ggc gac gat Thr Giy Asp Asp gtg Val1 ato otc Ile Leu go cag qca tcc Gly Gin Ala Ser ccc Pro aac ggt gcg got Asn Gly Ala Ala gca ctg ggo cgt Ala Leu Gly Arg gtt Val1 gtt got cta gat Val Ala Leu Asp aag ott ggc caa Lys Leu Gly Gin gtt cca ggc atg Val Pro Gly met cag Gin ctt gat cgc cgc Leu Asp Arg Arg ggt toc ggo ctg Giy Ser Giy Leu goa ato gto ac Ala Ile Val Thr gct gct Ala Ala 100 gca cac gtt Ala His Val gaa tcc atg Giu Ser Met 120 gca Ala 105 too ggc got gct Ser Gly Ala Ala gat Asp 110 ctg ato atc gca Leu Ile Ile Ala ggt ggc gca Gly Gly Ala 115 ato cgt tgg Ile Arg Trp agc ogc gtt gag Ser Arg Val Giu acc gtq tcc ggc Thr Val Ser Gly gat Asp 130 ggt gtc Gly Val 135 aag ggc ggc gac Lys Gly Gly Asp atg Met 140 cag ott cgt gac Gin Leu Arg Asp cgc Arq 145 ctt gca gaa goa Leu Ala Giu Ala ogc Arg 150 gaa acc gct ggc Giu Thr Ala Gly cgc aac cac ccg Arg Asn His Pro oct ggt ggc atg Pro Gly Giy Met gag acc got gag Giu Thr Ala Giu ctg cgt cgc gaa Leu Arg Arg Giu ggc atc tcc ogc Gly Ile Ser Arq gag gag Giu Glu 180 cag gac aag Gin Asp Lys gat gcg ggg Asp Ala Gly 200 too gca gog tco Ser Ala Ala Ser cag Gin 190 cag cgt tgg ggc Gin Arg Trp Gly aag got got Lys Ala Ala 195 gtc cot gc Val Pro Ala 691 739 Ott tto gac gac Leu Phe Asp Asp ato gtg cca gtc Ile Val Pro Val acc Thr 210 aag aag cgc ggc cag gag cca acc atc gtt tct cga gao gag cat ggt Lys Lys 215 Arq Giy Gin Giu Thr Ile Val Ser Arg 225 Asp Glu His Gly oga Arg 230 cca gga aca aco Pro Gly Thr Thr gtC Val 235 gaa aag ctt gct Glu Lys Leu Ala ttg cgc ccc atc Leu Arg Pro Ile ggc cgc cag gat Gly Arg Gin Asp gaa gca acc gtc Giu Ala Thr Val got ggc aac gcg Ala Gly Asn Ala tcc ggc Ser Gly 260 caa aat gat Gin Asn Asp gag gag aag Giu Giu Lys 280 ggC Gly 265 gct gct gcc gtc Ala Ala Ala Val att Ile 270 gtg acc act cgc Val Thr Thr Arg gcc aag 9CC Ala Lys Ala 275 tgg tct gtg Trp Ser Val ggc ctg ogo cca Gly Leu Arg Pro atg cgt ttg got Met Arg Leu Ala ggc Gi y 290 gCt gct Ala Ala 295 gtt ccc cca gag Val Pro Pro Glu acc Thr 300 atg ggt att gga Met Gly Ile Gly gtt cot 9CC acc Val Pro Ala Thr aag Lys 310 aag gtc ctg gat Lys Val Leu Asp cg t Arg 315 ttg ggc ctt acc Leu Gly Leu Thr gag gac atc ggc Giu Asp Ile Giy 1027 1075 1123 atc gaa ctc aac Ile Glu Leu Asn gct ttc gca got Ala Phe Ala Ala gca otg tct gtg Ala Leu Ser Val ctg aag Leu Lys 340 gaa tgg aac Giu Trp Asn ggt att too Gly Ilie Ser 360 att Ile 345 tot tgg gaa gat Ser Trp Giu Asp gag Gi u 350 ogo gto aao ooa Arg Val Asn Pro otg gqt too Leu Gly Ser 355 cgo atg gca Arg Met Ala atg gga oac ooa Met Gly His Pro ggt goc aoo ggt Gly Ala Thr Gly got Ala 370 gta aco Val Thr 375 ttg got oao ogo Leu Ala His Arg cag cgt gaa aao Gin Arg Glu Asn oag tao gga otg Gin Tyr Giy Leu 1171 1219 1267 1315 1347 gco Ala 390 aoo atg tgc ato Thr Met Cys Ile gg t Gly 395 ggo ggo cag ggt Gly Gly Gin Giy gca got gtc ttt Ala Ala Val Phe aag gag aac Lys Glu Asn taaaaatggc tattttgcao ago <210> 96 <211> 408 <212> PRT <213> Corynebaoterium glutamicum <400> 96 Met Asn Pro Gin Asp Ile Val Ile Cys Ser Pro Leu Arg Thr Pro Val 1 5 10 Gly Ala Tyr Gly Gly Ser Phe Thr Gly Val Pro Val Giu Glu Leu Ala 25 Thr Thr Val Ile Asn Ala Ile Val Giu Ala Thr Gly Ile Thr Gly Asp 40 Asp Val Asp Asp Leu Ile Leu Gly Gin Ala Ser Pro Asn Gly Ala Ala 55 Pro Ala Leu Gly Arg Val Val Ala Leu Asp Ser Lys Leu Gly Gin Asn 70 75 Val Pro Gly Met Gin Leu Asp Arq Arg Cys Giy Ser Giy Leu Gin Ala 90 Ile Val Thr Ala Ala Ala His Vai Ala Ser Gly Ala Ala Asp Leu Ile 100 105 110 Ile Ala Gly Gly Ala Giu Ser Met Ser Arg Val Giu Tyr Thr Val Ser 115 120 125 Gly Asp Ile Arg Trp Gly Val Lys Gly Gly Asp Met Gln Leu Arg Asp 130 135 140 Arg Leu Ala Giu Ala Arg Giu Thr Ala Gly Gly Arg Asn His Pro Ile 145 150 155 160 Pro Gly Gly Met Ile Giu Thr Ala Giu Asn Leu Arg Arg Glu Tyr Gly 165 170 175 Ile Ser Arg Giu Giu Gin Asp Lys Ile Ser Ala Ala Ser Gin Gin Arg 180 185 190 Trp Gly Lys Ala Ala Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro 195 200 205 Val Thr Val Pro Ala Lys Lys Arg Gly Gin Giu Pro Thr Ile Val Ser 210 215 220 Arg Asp Giu His Gly Arg Pro Gly Thr Thr Val Giu Lys Leu Ala Ala 225 230 235 240 Leu Arg Pro Ilie Met Gly Arg Gin Asp Ala Giu Ala Thr Val Thr Ala 245 250 255 Gly Asn Ala Ser Gly Gin Asn Asp Gly Ala Ala Ala Val Ile Val Thr 260 265 270 Thr Arg Ala Lys Ala Giu Giu Lys Gly Leu Arg Pro Val Met Arg Leu 275 280 285 Ala Gly Trp Ser Val Ala Ala Val Pro Pro Giu Thr Met Gly Ile Gly 290 295 300 Pro Val Pro Ala Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu 305 310 315 320 Giu Asp Ile Gly Ala Ile Giu Leu Asn Glu Ala Phe Ala Ala Gin Ala 325 330 335 Leu Ser Val Leu Lys Glu Trp Asn Ile Ser Trp Giu Asp Glu Arg Val 340 Asn Pro Leu Gly Ser 355 Gly Ala Arg Met Ala 370 Thr Gin Tyr Gly Leu 385 Ala Ala Val Phe Glu 405 345 350 Gly Ile Ser Met Gly His Pro Val Gly Ala Thr 360 365 Val Thr Leu Ala His Arg Met Gin Arg Giu Asn 375 380 Ala Thr Met Cys Ile Gly Gly Gly Gin Gly Leu 390 395 400 Lys Giu Asn (210> 97 <211> 815 <212> DNA <213> Corynebacterium glutamicum <220> (221> CDS <222> <223> FRXA01114 <400> 97 cgc Arg 1 cct Pro atc Ile tgg T rp gtc Val1 eqa Arg ttg Le u ggc Gi y act Thr ga a Gi u at g Met gag Glu gc t Ala cc t Pro cat His at c Ile 100 tcc Ser aag Lys cgc Arg gag Glu cag Gin ga t Asp aag Lys 70 cga Arg ggc Gly caa Gin gag Glu g gc Giy 10 aac Asn tcc Ser ttc Phe cag Gin acc Thr g c9 Ala gct Ala ctg Leu cgc Arg cg t Arg g cg Ala gac Asp cca Pro gaa Giu gca Al a gcc Ala aac Asn cgc Ar g tcc Ser gag Glu acc Thr aag Lys acc Thr gtc Val1 125 ccg Pro tac Tyr cag Gin gtg Val1 gtt Val1 gct Ala acc Thr gtg Val atc Ile Gly cgt Arg cca Pro tct Se r gct Ala gct Ala acc Thr cgc cca gtc atg cgt ttg Arg Pro Val Met Arg Leu 1.40 gct ggc tgg tct gtg gct gct gtt ccc cca gag Ala Gly Trp Ser Val Ala Ala Val Pro Pro Glu acc atg ggt Thr Met Gly att gga Ile Gly 160 145 cct Pro gag Glu ctg Leu aac As n ggt Gly 225 act Thr gca Ala cct Pro atc I le gtg Val1 195 ct g Le u cgc Arg tac T yr gtc Val1 gcc Ala ggc Gly 180 Ctg Leu ggt Gly atg Met gga Gl y ttt Phe 260 acc Thr 165 gcg Al a aag Lys tcc Ser gca Al a ctg Le u 245 gtc ctg gat Val Leu Asp 170 ctc aac gaa Leu Asn Glu 185 aac att tct Asn Ile Ser 200 tcc atg gga Ser Met Gly ttg gct cac Leu Ala His atg tgc atc Met Cys Ile 250 155 Cgt Arg qct Ala tgg Trp cac His cgc Arg 235 ggt Gly ggc ctt acc ctg Gly Leu Thr Leu 175 gca gct cag gca Ala Ala Gin Ala 190 gat gag cgc gtc Asp Glu Arg Val 205 gtc ggt gcc acc Val Gly Ala Thr cag cgt gaa aac Gin Arg Glu Asn 240 ggc cag ggt ctt Gly Gin Gly Leu 255 480 528 576 624 672 720 768 gaa aag gag aac Glu Lys Glu Asn taaaaatggc tattttgcac agc 815 <210> 98 <211> 264 <212> PRT <213> Corynebacterium glutamicum <400> 98 Arq Leu Ala Glu Ala Arq Glu Thr Ala 1 Pro Gly Gly Met Ile Giu Thr Ala Glu Ile Ser Arg Glu Giu Gin Asp Lys Ile Trp Gly Lys Ala Ala Asp Ala Gly Leu 55 Val Thr Val Pro Ala Lys Lys Arg Gly 70 Arg Asp Giu His Gly Arg Pro Gly Thr Leu Arg Pro Ile Met Gly Arg Gin Asp 100 105 Gly Leu Ala Asp Giu 75 Val Glu Arg Arg Ala Asp Pro Glu Ala Ile Gl y Arg Pro Se r Al a Ala Gly Thr Ala 145 Pro Glu Leu As n Gly 225 Th r Al a Asn Arg 130 Gl y Val1 Asp Ser Pro 210 Ala Gln Ala Ala 115 Ala Trp Pro Ile Val1 195 Leu Arg Tyr Val1 Gln Glu Ala 150 Lys Ile Glu Gl y Val1 230 Ala Lys As n Glu 135 Ala Lys Glu T rp Ile 215 Thr Thr Glu Asp 120 Lys Val1 Va 1 Le u As n 200 Ser Le u Met As n Gly Gly Pro Le u As n 185 Ile Met Ala Cys Ala Le u Pro Asp 170 Glu Ser Gly His Ile 250 Ala Arg Glu 155 PArg Ala Trp His Arg 235 Gly Ile Met Gi y Leu Ala 190 Giu Gly Ar g Gin Val1 Arg Ile Thr 175 Gin Arq Ala Glu Gly 255 <210> 99 <211> 978 <212> DNA <213> Corynebacterium glutamicum (220> <221> CDS <222> (955) <223> RXA01894 <400> 99 agaatttttt cgaaaatgct ggcaccatca acagtgacat acccatgaat gaaccggaqc aacatcaccg qtccatqaqg aat As n ctg Leu tac Tyr agc aat Asn ggg Gly atc Ile a ga gc9 Ala gt c Val1 ctc Leu ctt ctc Leu ttg Leu ttt Phe ggC aaa Lys qgg Gi y atg Met 45 tat gcc Ala gt c ValI gca Al a ttg att Ile cta Leu gca Ala cca tgttagaaac ttcaaggaga atq ccc aaa ccc aaa Met Pro Lys Pro Lys 1 gct gtq ggg atc qqa Ala Val Gly Ile Gly agc cca tgg ggt tgg Ser Pro Trp Gly Trp aca tgg gaa gtt gqt Thr Trp Glu Val Gly ctq cog att atg atc Ser Arg Leu Lys Glu Gly Tyr His Leu Pro Pro Ile Met Ile atc Ile ggc ggt cag gca Gly Gly Gin Ala atc tgg ctg tca Ile Trp Leu Ser t gg Trp cca ttt ggc acg Pro Phe Gly Thr 355 403 ggc att ttg gcg Gly Ile Leu Ala tct Ser ttt gtg gcc act Phe Val Ala Thr gtg Vali 95 ttg gtg ctg atg Leu Val Leu Met tat ttc Tyr Phe 100 cga att ttc Arg Ile Phe gac acc tct Asp Thr Ser 120 aat ggc acg gaa Asn Gly Thr Glu gaa gcc cgc aac Glu Ala Arg Asn tat ttg agg Tyr Leu Arg 115 ttg ttc gga Leu Phe Gly gtg ggc atc ttc Val Gly Ile Phe gt g Val1 125 ctc acc tgg att Leu Thr Trp Ile cca Pro 130 agc ttc Ser Phe 135 gct gcg atg ctg Ala Ala Met Leu ctg atg caa aac Leu Met Gin Asn tcc atc ccg ggt Ser Ile Pro Gly aca Thr 150 tat ttc att ttg Tyr Phe Ile Leu ttc atg ctg tgt Phe Met Leu Cys gtg Val1 160 atc gca tcg gat Ile Ala Ser Asp ggc gqg tat atc Gly Gly Tyr Ile gcg Ala 170 ggt gtg ttc ttt Gly Val Phe Phe gga Gly 175 tcg cac cca atg Ser His Pro Met gcg ccg Ala Pro 180 ttg gtg agt Leu Val Ser tta gga tcg Leu Gly Ser 200 aaq aaq tct tgg Lys Lys Ser Trp ga a Glu 190 ggc ttt gcc ggc Gly E'he Ala Gly tcc att. gtc Ser Ile Val 195 ctc gat cac Leu Asp His 691 739 gtc act ggt gca Val Thr Gly Ala agt gtt cac ttc Ser Val His Phe cac tgg His Trp 215 tgg atg ggt gtg Trp Met Gly Val ttg ggt tgt gcc Leu Gly Cys Aia gtt gtg tgc gcc Val Val Cys Ala a cg Thr 230 ttg ggt qac ttq Leu Gly Asp Leu gtt Val1 235 gag tcgj cag ttc Giu Ser Gin Phe cqc qat ttg ggc Arg Asp Leu Gly 787 835 883 aag gat atg tcg Lys Asp Met Ser ctt ctt cca ggc Leu Leu Pro Gly ggc qga ttq atg Gly Gly Leu Met gac cgt Asp Arg 260 ttg gat ggc Leu Asp Gly gtg atc agc Val Ile Ser 280 <210> 100 atg Met 265 ctc ccg gcc gcg Leu Pro Ala Ala atg Met 270 gtg acg tgq ttg Val Thr Trp Leu atc ctg agt Ile Leu Ser 275 agc tcg tat ccg Ser Ser Tyr Pro taaagcttgg gccagcttta agt <211> 285 <212> PRT <213> Corynebacterium glutamicum <400> 100 Met Pro Lys Pro 1 Ala Val Gly Ile Ser Pro Trp Gl~y Thr Trp Glu Val Leu Pro Ile Met Pro Phe Gly Thr Val Leu Met Tyr 100 Arg Asn Tyr Leu 115 Ile Pro Leu Phe 130 Asn Ser Ile Pro 145 Ile Ala Ser Asp His Pro Met Ala 180 Ala Gly Ser Ile 195 Phe Leu Leu Asp 210 Leu Val Val Cys 225 Arg Asp Leu Gly Gly Leu Met Asp 260 Trp Leu Ile Leu 275 <210> 101 Lys 5 Gly T rp Gly Ile Met Phe Arg Gly Gly Val1 165 Pro Val1 His Al a Ile 245 Arg Asn Asn Ala Gly Arg Asp Leu Lys Ala Ala Ile be u Tyr Se r Ile 70 Gly Arg Asp Ser Thr 150 Gly Leu Leu His Thr 230 Lys be u Gly Ile Arg 55 Gly Ile Ile Thr Phe 135 Tyr Gly Val1 Gi y Trp 215 Leu Asp Asp Val1 be u 40 Le u Gly Le u Phe Se r 120 Al a Ph e Tyr Ser Ser 200 Trp Gly Met Gi y Ser 280 Leu 25 Val1 Lys Gin Al a Tyr 105 Val Al a Ile Ile Pro 185 Val1 Met Asp Ser Met 265 Val1 Al a Giu Ala Ser As n Gi y Met Leu Al a 170 Lys Thr Gly Leu As n 250 Leu Le u Gi y Gly Ile 75 Ph e Gly Ile Le u Thr 155 Gi y Lys Gly Val1 Val1 235 Le u Pro Leu Phe Gly Ile Val1 Thr Phe Se r 140 The Val1 Ser Ala Ile 220 Glu Leu Al a Gly Met T yr Trp Ala Glu Val1 125 Le u Met Phe Trp Leu 205 Leu Se r Pro Ala Ile Ala His Leu T hr Lys 110 Leu Met Leu Phe Glu 190 Ser Gly Gin Gly Met 270 Leu Ala Pro Trp be u Al a Trp As n Val1 160 Ser Phe His Ala Lys 240 Gly Thr Ser Val Ile Ser Ser Tyr Pro (211> <212> <213> <220> <221> <222> <z223> 600 DNA Corynebacterium glutarnicum C DS (577) RXA02599 <400> 101 gatcaagcat catacgatgt cggagattgt ggcggqcgtt cggcatttgt tatgcactce tacttgcgta aaggagaatt gttacaggag cagttgcaac atg gat cag cta atc 11, Met Asp Gin Leu Ile etc gac gca ttt Leu Asp Ala Phe atc Ile ggc ttg aga gtq Gly Leu Arg Val act Thr 15 tgg ctg agt ccg Trp Leu Ser Pro gtg att Val Ile att ttg ttc Ile Leu Phe ett gtg tg Leu Val Trp cag etc acc ggg Gin Leu Thr Gly aca ctg atg ttt Thr Leu Met Phe gtg tat gcg Val Tyr Ala atc qcg gtg Ile Ala Val ggc ttg ttg cgc Gly Leu Leu Arg age gcc act gee Ser Ala Thr Ala eeg Pro ggg ctg Gly Leu get aat etg ate Ala Asn Leu Ilie agt Ser 60 cat ttt etc aag His Phe Leu Lys agg Arg geg ttt gaa egg Ala Phe Glu Arg cga cca aat aca Arg Pro Asn Thr gag cac ttg gtt Giu His Leu Val gaa act aae ttt Glu Thr Asn Phe 307 355 403 tte eet tet ggt Phe Pro Ser Gly eat His get gtg gge get Ala Val Gly Ala gea Al a 95 gca tgt gee gtg Ala Cys Ala Val gca gtg Ala Val 100 ggg tac tee Gly Tyr Ser etg ctt gtg Leu Leu Val 120 aae egg tgg tgg Asn Arg Trp Trp ete aeg etg tgg Leu Thr Leu Trp gta ate geg Val Ile Ala 115 tgg cee age Trp Pro Ser ggg etg tet egg Gly Leu Ser Arg tat gte gqt gtg Tyr Val Gly Val gat gtg Asp Val 135 et't gee ggc tgg Leu Ala Gly Trp gee Ala 140 ate ggt geg ttg Ile Gly Ala Leu act Thr 145 tea gtg gtg gtg Ser Val Val Val ace age tgg aae Thr Ser Trp Asn etc eag ege ege Leu Gin Arg Arg tgaaaccact gctgaaagtg <210> 102 <211> 159 <212> PRT <213> Corynebacteriun glutamicum <400> 102 Met Asp Gin Leu Ile Leu Asp Ala Phe Ile Gly Leu Arg Val Thr Trp 1 Le u Met Al a Arg Glu Cys Le u Val1 Thr 145 Pro Val1 Ile Phe Asn Val1 Val1 115 T rp Val1 Val1 Tyr Al a Gi u Phe Al a 100 Ile Pro Val1 Ile Leu Gly Pro '70 Phe Gly Le u Asp Phe 150 Le u Val Leu Arg Pro Tyr Leu Val 135 Thr Phe Trp 40 Ala Pro Ser Ser Val 120 Leu Ser Leu Le u Ile Ala 75 Al a Arg Ser Trp Leu 155 Gly Lys His His Gly Trp Leu 125 Ile Gin Pro Ser Phe Le u Al a Lys 110 Tyr Gly Arg Thr Ala Leu Val1 Ala Leu Val Ala Arg Le u Th r Lys Val1 Al a Thr Gi y Le u <210> 103 <211> 999 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(976) <223> RXN02638 <400> 103 ctctgttgtt gttcctgagg cgcttcgtcc attcgtgqgc gaaacaagcc ggttaattaa gcggaaagct cgtggtcgac ggc ttt ttc Gly Phe Phe gag tca cgg Glu Ser Arg acg gtg atg gta gag gat tcc ctg cct aag gtt Val Glu Asp Ser Leu Pro Lys Val 15 gag acg ttt tat ggg cgc atc atc Glu Thr Phe Tyr Gly Arg Ile Ile 30 aaa gcc cag gat gtg cag att tcc aaagacgtgc tcaagccagt atg gtc aaa agg ttt Met Val Lys Arg Phe 1 ccg ctg cat ccc gaa Pro Leu His Pro Giu att agt gct gtg cgg Ile Ser Ala Val Arg atc ttc ggt gcg gag Thr Vai Met Lys Ala Gin Asp Val Gin Ile Ser Ile Phe Giy Ala Giu aac att Asn Ile ccg acc acc ggc Pro Thr Thr Gly gca ctt ttc gca Ala Leu Phe Ala acc aca ctg gtt Thr Thr Leu Val att Ile atg act tca ttc Met Thr Ser Phe gtg gta tcc ccc: Vai Val Ser Pro gca Aia ttc gtg cgg ggt Phe Vai Arg Gly cgc ctg gtt cga Arg Leu Val Arg ttc Phe atg gcg aag aag Met Ala Lys Lys att ttc gac acc Ile Phe Asp Thr cca gtt Pro Val 100 gtc ggc acc Val Gly Thr gca ggt gcc Ala Gly Ala 120 atg cgc tgg atg Met Arg Trp Met aag Lys 110 cac gtc tct gtg His Vai Ser Val gac cgc tcc Asp Arg Ser 115 qac gcc ggc Asp Ala Gly ggt tcc atg gaa Gly Ser Met Giu gcg cgg aaq cgt Ala Arg Lys Arg agc ctc Ser Leu 135 gtc: ggt atc ttc Val Giy Ile Phe gag gcg acg gtg Glu Ala Thr Val t ca Ser 145 cgg tcc ttt gaa Arg Ser Phe Glu atec Ile 150 aag gaa cta aaa Lys Glu Leu Lys act Thr 155 ggc gec gtc cgc: Gly Ala Vai Arg gec gac agc gct Ala Asp Ser Ala gtt ccg ctg ctg Val Pro Leu Leu ctt att att tgg Leu Ile Ile Trp ggc Cag cgc atc Gly Gin Ar Ile atc acc Ile Thr 180 aaa gac atc Lys Asp Ilie agc gtg ggt Ser Val Gly 200 gag Glu 185 cgc gac ttc ggc Arg Asp Phe Gly cgc Arg 190 tcc cac ate ccc Ser His Ile Pro gta ttc atc Vai Phe Ile 195 gaa gca acg Giu Ala Thr gaa ccc gtc gac Giu Pro Val Asp agc ggc gat ccc Ser Gly Asp Pro gac Asp 210 gaa cgc Giu Arg 215 ctc: tac gag gct Leu Tyr Giu Ala aaa aag ctt ctc Lys Lys Leu Leu gac Asp 225 gaa acc cgc acc Glu Thr Arg Thr gcc Al a 230 tac gaa caa aag Tyr Glu Gin Lys tat Tyr 235 ggc cca ttc gaa Gly Pro Phe Glu ggt Gly 240 gga gaa ttg tgg Gly Giu Leu Trp cgc Arg 245 ccg aaa tcc ctc Pro Lys Ser Leu ggc ggc gcc: cca Gly Gly Ala Pro ttg gag cag gcg Leu Giu Gin Ala aaa atg Lys Met 260 ttg gaa atc Leu Glu Ile gcc Al a 265 gaa cgg gaa cgt Glu Arg Glu Arg cga Arg 270 caa gca aaa cgc Gin Ala Lys Arg gcg gca aag Ala Ala Lys 275 gtc gcc aag aaa cgc acc acc ttt ata agg aaa atc ttt aaa aaa Val Ala Lys Lys Arg Thr Thr Phe Ile Arg Lys Ile Phe Lys Lys ID280 285 290 tgattgcact gggttcagcg ccc 999 <210> 104 <211> 292 (212> PRT <213> Corynebacterium giutarnicum <400> 104 Met Val Lys Arg Phe Gly Phe Phe Val Giu Asp Ser Leu Pro Lys Vai 1 5 10 S Pro Leu His Pro Glu Glu Ser Arg Glu Thr Phe Tyr Gly Arg Ile Ile 25 Ile Ser Ala Val Arg Thr Val Met Lys Ala Gin Asp Val Gin Ile Ser 40 Ile Phe Gly Ala Glu Asn Ile Pro Thr Thr Giy Gly Ala Leu Phe Ala 55 Ser Thr Thr Leu Val Ile Met Thr Ser Phe Trp Val Val Ser Pro Ala 70 75 Phe Val Arg Gly Lys Arg Leu Val Arg Phe Met Ala Lys Lys Giu Ile 90 Phe Asp Ti-r Pro Vai Val Gly Thr Leu Met Arg Trp Met Lys His Val 100 105 110 Ser Val Asp Arq Ser Ala Gly Ala Gly Ser Met Glu Asp Ala Arg Lys 115 120 125 Arg Leu Asp Ala Gly Ser Leu Val Gly Ile Phe Pro Glu Ala Thr Val 130 135 140 Ser Arg Ser Phe Glu Ile Lys Giu Leu Lys Thr Gly Ala Val Arg Ile 145 150 155 160 Ala Asp Ser Ala Asn Val Pro Leu Leu Pro Leu Ile Ile Trp Gly Gly 165 170 175 Gin Arg Ile Ile Thr Lys Asp Ile Glu Arg Asp Phe Giy Arg Ser His 180 185 190 Ile Pro Val Phe Ile Ser Val Gly Giu Pro Val Asp Ala Ser Gly Asp 195 200 205 Pro Asp Glu Ala Thr Glu Arg Leu Tyr Glu Ala Met Lys Lys Leu Leu 210 215 220 Asp Glu Thr Arg Thr Ala Tyr Glu Gin Lys Tyr Gly Pro Phe Giu Gly 225 230 235 240 Gly Giu Leu Trp Arg Pro Lys Ser Leu Gly Gly Gly Ala Pro Thr Leu 245 250 255 Giu Gin Ala Lys Met Leu Glu Ile Ala Glu Arq Giu Arg Arg Gln Ala 260 265 270 Lys Arg Ala Ala Lys Val Ala Lys Lys Arg Thr Thr Phe Ile Arg Lys 275 280 285 Ile Phe Lys Lys 290 <210> <211> <212> <213> <220> <221> <222> <223> 105 534 DNA Corynebacterium giutarnicum C DS (511) FRXA02 638 <400> 105 atqaagaatq qcg cqq Met Ala Arg 1 aag eqt Lys Arg 5 ctt aac gcc ggc agc ctc gte ggt ate Leu Asn Ala Gly Ser Leu Val Gly Ile ttc Ph e cet gag gcg acg Pro Glu Ala Thr gtq Val1 tea cqg tee ttt Ser Arg Ser Phe atc aag gaa eta Ile Lys Glu Leu act ggc gcc gtc Thr Gly Ala Val atc qcc gac age Ile Ala Asp Ser get Ala aac gtt ccg ctg Asn Val Pro Leti ctg eca Leu Pro ctt att att Leu Ile Ile gac ttc ggc Asp Phe Gly ggc ggc cag cgc Giy Gly Gin Arg atc acc aaa gac Ile Thr Lys Asp atc gag cgc Ile Giu Arg ggt gaa ccc Gly Glu Pro 193 241 cgc tee cac atc Arg Ser His Ile gta tte ate age Val Phe Ile Ser gte gac Val Asp gcc agc gge gat Ala Ser Gly Asp gac gaa gca acg Asp Giu Ala Thr gaa Giu ege etc tac gag Arg Leu Tyr Glu atg aaa aag ctt Met Lys Lys Leu etc Leu 100 gac qaa ace eqe Asp Giu Thr Arg gee tac gaa caa Ala Tyr Giu Gin 289 337 385 tat ggc eca tte Tyr Gly Pro Phe ggt gga gaa ttg Gly Gly Giu Leu ege ceg aaa tee Arg Pro Lys Ser etc ggc Leu Gly 125 gge gge gee Gly Giy Ala egg gaa egt Arg Giu Arg 145 cea Pro 130 aeg ttg gag cag Thr Leu Giu Gin aaa atg ttg gaa Lys Met Leu Glu ate gee gaa Ile Aia Glu 140 aag aaa 'cge Lys Lys Arg 433 481 ega eaa gca aaa Arg Gin Ala Lys geg gca aag gte Ala Ala Lys Val ace ace ttt ata agg aaa ate ttt aaa aaa Thr Thr Phe Ile Arg Lys Ile Phe Lys Lys tgattgeaet gggttcagcg ccc <210> 106 <211> 168 <212> PRT Corynebacterium qiutamicum <400> 106 Met Ala Arg Lys 1 Giu Ala Ile Gly Al a Lys Pro Ala Arq 145 Phe Ala Val1 Trp Arg Ser Lys Phe Pro 130 Arg Ile Val1 Ile Gi y His Asp Leu 100 Gly Le u Al a Lys Arg 5 Ser Al a Gin Ile Pro Asp Gly Glu Lys Ile 165 Leu Asn Ala Gly Arg Asp Arg Pro 70 Asp Glu Glu Gin Arg 150 Phe Ser Ser Ile 55 Val1 Giu Thr Leu Ala 135 Ala Lys Phe Al a Ile Phe Al a Arg Trp 120 Lys Al a Lys Ser Ile Val1 Lys Ser Glu Al a Pro Leu Val1 Le u Lys Pro Asp Val1 75 Arg Tyr Lys Giu Aila 155 Val1 Giu Le u Ile Gly Le u Giu Ser Ile 140 Lys Giy Leu Le u Glu Giu Tyr Gin Leui 125 Ala Lys Pro Gly Ile Phe Asp Met Gly Gly Giu Thr 160 <210> 107 <211> 637 <212> DNA <213> Corynebacterium qiutamicum <220> <221> CDS <222> (637) <223> RXA00856 <400> 107 gtttttagga atagagtggg ctcaagcttt gtgacaagtt ttttqgaqaa atcattacta gtcgtagtct tcaatttggg tgcaggtagg gtggaacacc gtq agt gat gta tca 115 Vai Ser Asp Val Ser 1 gca ggc gta aat Ala Gly Val ASn gca caa gat cca Ala Gin Asp Pro agc Ser aat caa gcg gtc Asn Gin Ala Val aag Oct. Lys Pro tcc aac tgg Ser Asn Trp, atc cot ttg Ile Pro Leu ctt ccg aac ttc Leu Pro Asn Phe acc agc ttg cgt Thr Ser Leu Arg ate att gte Ile Ile Val gaa aac aat Giu Asn Asn ttt gcg tgg ott Phe Aia Trp, Leu acg Thr 45 ctt aaa ggt gag Leu Lys Gly Giu a cg Thr got. ttt Ala Phe gc tgg tgg gcg Ala Trp, Trp Ala gtt gtt tto att Val Vai Phe Ile otc atg ato aco Leu Met Ile Thr gao Asp aag ott gac ggo Lys Leu Asp Gly att gog cqa goa Ile Ala Arg Ala cg t Arg ggc otg gtc act Gly Leu Vai Thr ttt ggc aag ato Phe Gly Lys Ile gat cog att gc Asp Pro Ile Ala aag gcg ttg atg Lys Ala Leu Met aco aca Thr Thr 100 gca ttt gtc Ala Phe Val gcg tig att Ala Leu Ilie 120 tto aac ato atc Phe Asn Ile Ile ggc Gly 110 att ttg ccc tgg Ile Leu Pro Trp tgg gtc act Trp Val Thr 115 cgt ttc ttc Arg Phe Phe 451 499 gtg ott oga gag Val Leu Arg Giu ggc att aco ato Gly Ile Thr Ile tgg Trp 130 caa ctg Gin Leu 135 aag act Lys Thr 150 ogo got gga aat Arg Ala Gly Asn gtg cot gca toa Val Pro Ala Ser ggg ggc aag ott Gly Gly Lys Leu got otg cag Aia Leu Gin gtt goc gtt got Val Ala Val Ala ctg Le u 160 tat ctg tgo cot Tyr Leu Cys Pro oca agt tgg atg Pro Ser Trp, Met gat Asp 170 att eca ago cag Ile Pro Ser Gin gto atg tat qca. Val Met Tyr Ala <210> 108 <211> 179 <212> PRT <213> Corynebacteriun giutamicum (400> 108 Val Ser Asp Vai Ser Ala Gly Val Asn 1 5 Gin Ala Val Lys Pro Ser Asn Trp Asn 25 Leu Arg Ile Ile Val Ile Pro Leu Phe 40 Ala Gin Asp Pro Ser Asn Leu Pro Asn Phe Leu Thr Ser Leu Lys Gly Ala Trp, Leu Thr Glu Leu Gly Al a Pro Ile Lys 145 T yr Met Th r Leo Leu Leu Trp Trp 130 Gly Leu Tyr As n Th r As p Th r Thr Phe Leo Phe 165 Ala Asp 70 Phe Al a Al a Gin Lys 150 Pro Trp Asp Ile Cys 105 Val1 Al a Leu Met Trp Giy Ala 90 Phe Leo GI y Gin Asp 170 Ala Asp Asp Asn Arg Asn Thr 155 Ile Val Arg Ala Gly 110 Giy Pro Val Gin Phe Al a Asp Ile Ile Ala Ala Ile 175 <210> 109 <211> 780 <212> DNA <213> Corynebacterium giutamricorn <220> <221> CDS <222> (757) <223> RXA02511 <400> 109 ccatgcttgO gcaagcatgg ggcaccattg atggggcaoc tgacttcagc gatccgtacc gcagcaccga aggagcactg gga Gly a tc Ile ctc Leo t gg T rp aag Lys ttg Leu gtt Val1 gca Al a cag Gin acg Thr got Ala acg Thr gt t Vai oct Pro ttg Leu ggc Gly gt t Val cag Gin ctg Leo ttt Phe cot Pro aco Thr ct Pro got Ala aggoaotgto gacccaacgc atg ctg gga ctt cat Met Leu Gly Leu His 1 gtt goc aaa ttg atg Val Ala Lys Leo Met tta gto ago got ggc Leo Val Ser Ala Gly aog ggg cat ttg att Thr Gly His Leo Ile ttc gao atg att gat Phe Asp Met Ile Asp ggc acg gtt gct cgc Gly Thr Val Ala Arg atg Met caa ggt ggt ggc Gin Giy Gly Gly acc aaa ttt ggt gcc acc Thr Lys Phe Gly Ala Thr 75 ttg gat gcc acg tgt gac cgc atc act Leu Asp Ala Thr Cys Asp Arq Ile Thr att acc tgg tgg ctg gtg tat tcc tac Ile Thr Trp Trp Leu Val Tyr Ser Tyr 105 110 gct gcc tcc ttg gtt tgt ttg gtt gcc Ala Ala Ser Leu Val Cys Leu Val Ala 120 125 aaa gcc agg gga gag gcc tcc gga ttc Lys Ala Arg Gly Giu Ala Ser Giy Phe 135 140 gaa cgc cct gag cgt ctg att gtc agc Glu Arg Pro Glu Arg Leu Ile Val Ser 150 155 gga atg ggc gtt cca tat gcc atc gat Giy Met Giy Val Pro Tyr Ala Ile Asp 170 gct ggc agt att tac act gtt gtg cag Ala Gly Ser Ile Tyr Thr Val Val Gin 185 190 tcc cca ttg qct aag qaa ttt acc aag Ser Pro Leu Ala Lys Glu Phe Thr Lys 200 205 gat tac agc aac acc aaa taaaaattag c Asp Tyr Ser Asn Thr Lys 215 <210> 110 <211> 219 <212> PRT <213> Corynebacterium glutamicum <400> 110 Met Leu Gly Leu His Gly Arg Lys Pro 1 5 Vai Ala Lys Leu Met Ile Lys Leu Lys Leu Val Ser Ala Gly Leu Thr Val Gly Thr Gly His Leu Ile Trp Ala Ala Val 55 Phe Asp Met Ile Asp Gly Thr Val Ala 70 ga t Asp 95 ga t Asp tcc Ser acc Thr ctt Le u gtg Val1 175 cgc Arg gca Al a 80 ggt GI y g ca Ala cag Gin atg Met gtt Val1 160 gca Ala ttg Le u cca Pro gca Al a cca Pro gtg Val1 ga c Asp 145 ggt Gly ctg Le u gtc Val1 gca Al a ttt Phe gca Ala 115 t ct Ser ggt Gly ggg Gl y gcc Al a gct Ala 195 gC g Al a ggt Gly 100 ttg Leu tac Tyr ctc Leu Ctg Leu ctt Leu 180 gga Gly aag Lys gcg Al a gtc Val1 gtg Val1 gtg Val1 acc Thr 165 gca Al a aag Lys gca Al a ~cgagggagc atc Ala 10 Val1 Val Leu Arg Gin Thr Al a Thr Met 75 Val1 Pro Leu Gly Gin Giu Leu Ile Ala Gly Pro Thr Pro Ala Thr Lys Phe Gly Ala Thr Leu Asp Ala Thr Cys Asp 90 Ala Leu Phe Gly Ala Ile Thr Trp Trp Leu Val 100 105 Pro Gin Ala Leu Val Ala Ala Ser Leu Val Cys 115 120 Val Ile Ser Tyr Val Lys Ala Arg Gly Glu Ala 130 135 Asp Gly Gly Leu Val Glu Arg Pro Glu Arg Leu 145 150 155 Gly Leu Gly Leu Thr Gly Met Gly Val Pro Tyr 165 170 Leu Trp Ala Leu Ala Ala Gly Ser Ile Tyr Thr 180 185 Val Met Ala Gly Lys Ser Pro Leu Ala Lys Giu 195 200 Ala Gly Ala Lys Ala Asp Tyr Ser Asn Thr Lys 210 215 <210> 111 <211> 678 <212> DNA <213> Corynebacterium giutarnicum <220> <221> CDS <222> (101)..(655) <z223> RXN02836 <400> 111 ccatcactcg qcttcaccqt ctacggtgct gcccgcagga gcttcaqacg ggatccaccc cctcgagatg gacgtcaccg Ile Ser Val 125 Gi y Val1 Ile Val Thr 205 Asp Asp Ser Thr Leu Val 175 Arg Ala ggC Gly oga Arg aac Asn tat T yr cgt Arg ctc Leu atc Ile cac His ttc Ph e ccc Pro atg Met aag Lys gag Giu cac His 9gc Gly ttc Phe aat Asn cag Gin aag Lys ctc Leu ggc Gly aag Lys acg Thr ctc Leu cagagcgccc ccaaaagctc atg aca atc gat gaa Met Thr Ile Asp Giu 1 gcg atg qcc ctc acc Ala Met Ala Leu Thr tgg ggg acg atc gtg Trp Gly Thr Ile Val cct ctc ggc ggc tgg Pro Leu Giy Gly Trp tcg gac gcc ctc cgc Ser Asp Ala Leu Arg otg gag gtc gcc cca ttc ggc atc gac gtt gtt gtc atc gaa ccg ggc 355 Leu Giu Val Ala Pro Phe Gly Ile Asp Val Val Val Ile Glu Pro Gly 75 80 ggc atc goc aoo gag tgg gga gga atc gct gcc gac aat ctc gac gca 403 Gly Ile Ala Thr Glu Trp Gly Gly Ile Ala Ala Asp Asn Leu Asp Ala 95 100 gtg tcg aaa gac agc goa tao aag cgc cag got gac goa gta tcg aag 451 Val Ser Lys Asp Ser Ala Tyr Lys Arg Gin Ala Asp Aia Val Ser Lys 105 110 115 tcg ttg cga tot gag gcg aac ago aao ogo aao toa oca cog tog gtt 499 Ser Leu Arg Ser Glu Ala Asn Ser Asn Arg Asn Ser Pro Pro Ser Val 120 125 130 gtc goo gat gog att gga aag goc gtg aog goa cgt cac 000 aag aoo 547 Val Ala Asp Ala Ile Gly Lys Ala Vai Thr Ala Arg His Pro Lys Thr 135 140 145 ogo tat goc ato ggc tto ggt goo aaa cog otg att goc tog ogc aac 595 Arg Tyr Ala Ile Gly Phe Gly Ala Lys Pro Leu Ile-Ala Ser Arg Asn 150 155 160 165 ato oto aoo gat ogo cag tto gao cca gtg ato aot oga gog aot ggo 643 Ile Leu Thr Asp Arg Gin Phe Asp Pro Vai Ile Thr Arg Ala Thr Gly 170 175 180 gto coo ogc gao tgaooaotct tctgogooog toa 678 Val Pro Arg Asp 185 <210> 112 (211> 185 <212> PRT <213> Corynebacterium glutamicun <400> 112 Met Thr Ile Asp Glu Gly Arg Arg Gin Phe Giu Val Asn Val Phe Gly 1 5 10 Ala Met Ala Leu Thr Arg Leu Val Leu Pro His Met Gin Lys Gin Lys 25 Trp Gly Thr Ile Val Asn Ile Thr Ser Met Gly Gly Lys Ile Tyr Thr 40 Pro Leu Gly Gly Trp Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu 55 Ser Asp Ala Leu Arg Leu Glu Val Ala Pro Phe Gly Ile Asp Val Val 70 75 Val Ile Giu Pro Gly Gly Ile Ala Thr Giu Trp Gly Gly Ile Ala Ala 90 Asp Asn Leu Asp Ala Val Ser Lys Asp Ser Ala Tyr Lys Arg G1~n Ala 100 105 110 Asp Ser Arg 145 Ile Thr Ala Pro 130 His Ala Arg Ser Ser Lys Arg Thr 180 Lys Val1 Thr As n 165 Gly Leu Al a 135 T yr Leu Pro Giu Ala Asn Ser Asn Arg Asn 125 Ile Gly Lys Ala Val Thr Ala 140 Gly Phe Gly Ala Lys Pro Leu 155 160 Arg Gin Phe Asp Pro Val Ile 170 175 <210> 113 <211> 406 (212> DNA (213> Corynebacterium giutamicum <220> <221> CDS (222> (101) (406) <223> FRXA02836 <400> 113 coatoactcg gcttcaccgt ctacggtgct gcccgcagga cagagcgccc ccaaaagctc gottcagacg ggatocaccc ootogagatg gacgtoacog atg aca atc gat gaa Met Thr Ile Asp Giu ggc Gl y cga Arg aac Asn tat Tyr ctg Leu gqc Gly gtg Val1 ogo Arg gtc Val1 aca Thr ggc Giy gtc Val1 g00 Ala caq Gin ctg Leu t cg Ser acc Thr 9CC Al a acc Thr gag Glu cac His ggc Gly ttc Phe ttc Phe tqq Trp gtc Val1 atg Met ggg Gi y gcc Ala ggc Gly gga Gly aat Asn cag Gin aag Lys 45 ct 0 Le u at c Ile qqa Gly gt a Val1 aaa Lys 30 atc Ile gag Giu gao Asp atc Ile tto Phe ca a Gin tac Tyr 900 Al a gtt Val1 got Al a I gog Ala t gg T rp cot Pro tog Ser gtc Val1 gac Asp atg Met 999 Gly otc Leu gac Asp ato Ile aat As n gCC Ala a og Thr ggc Gly gc Ala gaa Giu ctc Leu otc Leu ato Ile ggc Gly ctc Leu cog Pro gac Asp 100 163 211 259 307 355 403 <210>' 114 <211> 102 <212> PRT <213> Corynebacterium glutamicum (400> 114 Met Thr Ilie Asp Glu Gly Arg Arg Gin Phe Glu 1 5 10 Ala Met Ala Leu Thr Arg Leu Val Leu Pro His Trp Gly Thr Ile Val Asn Ile Thr Ser Met Gly Pro Leu Gly Gly Trp Tyr His Gly Thr Lys Phe 55 Ser Asp Ala Leu Arg Leu Giu Val Ala Pro Phe 70 Val Ile Glu Pro Gly Gly Ile Ala Thr Glu Trp 90 Asp Asn Leu Asp Ala Val 100 <210> 115 <211> 1227 <212> DNA <213> Corynebacterium glutamieun <220> <221> CDS <222> (101)..(1204) <223> RXA02578 <400> 115 ggcaaaaatg aggaacagca cgeeegeaat aatgaggacc aacagcccac acetttccgc taaaetcgca tgttgaaata Val1 Met Gly Ala Gly Gly Phe Gin T yr Ala ValI Ala tat Tyr ege Arg acc Thr gac Asp gca Al a gca Ala tcc Ser ttt Phe ccc Pro ate Ile gte Val1 ttc Phe ate Ile gc Al a gac Asp gtc Val1 cqc cat Arg His tee ctg Ser Leu CCC 9CC Pro Ala gee gte Ala Val gga Gly gte Val1 aac As n 45 ttc Phe age Ser acc Thr gca Al a tee Ser gttgeagatc gcttcataaa atg tet ace caa tea Met Ser Thr Gin Ser 1 tea etc gag gga eta Ser Leu Giu Gly Leu cac gtt gca ttc caa His Val Ala Phe Gin gta etc geg cgt ttc Val Leu Ala Arg Phe gee ttc gtt ctt tgg Ala Phe Val Leu Trp 115 163 211 259 307 cgo cgc gcc ggg Arg Arg Ala Gly caa Gin oca gtg gga otg Pro Val Gly Leu tac ctc aaa cgc Tyr Leu Lys Arg cta Le u gcc cgc atc atg Ala Arg Ile Met ccc Pro gca tao tgg gca Ala Tyr Trp Ala a cg Thr 95 gtc att gca gtc Val Ile Ala Val ctg ctg Leu Leu 100 ttt att ccc Phe Ile Pro tac tgg cca Tyr Trp Pro 120 ggc ccc tgg tta Giy Pro Trp Leu aac ctg acg atg Asn Leu Thr Met acc caa atc Thr Gin Ile 115 tgg too ctg Trp Ser Leu gac ggg ctc atg Asp Gly Leu Met aca Thr 125 ggc oto acc cac Giy Leu Thr His Ott Leu 130 tgc gtg Cys Vai 135 gaa gtg gcg ttt Giu Val Ala Phe ctg gtg atg ccg Leu Val Met Pro ott Le u 145 cto qcg tgg gtg Leu Ala Trp Val t tg be u 150 gat agg ttt ggt Asp Arg Phe Gly ogg Arg 155 cog qtg cgc ato Pro Vai Arg Ile ttg att gtt ggt Leu Ile Val Giy 547 595 643 goa gtg ttg agt Ala Val Leu Ser gcg tgg ccg tgg Ala Trp Pro Trp 000 ott gtg gag Pro Leu Val Giu cat gcg His Ala 180 ttg gac gag Leu Asp Giu tgc tgg ttt Cys Trp Phe 200 ggg Gly 185 tgg gog aac atg Trp Ala Asn Met cag Gin 190 atc tgg cca coo Ile Trp Pro Pro gct tao gct Ala Tyr Ala 195 gga gtt cga Gly Vai Arq gca gto ggc atg Ala Val Gly Met goc gca gaa att Ala Ala Giu Ile ttc cca Phe Pro 215 cgg gtt ccg ago Arg Val Pro Ser gtg tgg gtg ggt Val Trp Val Gly tta, Leu 225 got tta gtg gtc Ala Leu Val Val tgg ato gog ggo Trp Ile Ala Gly oaa Gin 235 gaa tgg ttc gga Giu Trp Phe Gly ota ggt tta gtg Leu Gly Leu Vai 787 835 883 coo ago ooo tgg Pro Ser Pro Trp gaa. Giu 250 tto aao tta aga Phe Asn Leu Arg gtc Val1 255 ctc gog ggo aca Leu Ala Gly Thr ott tto Leu Phe 260 got gta ttt Ala Val Phe ott gat tco Leu Asp Ser 280 gtg gtt ooo tao Val Val Pro Tyr otg ggt acg 000 Leu Gly Thr Pro tot cgg ott Ser Arg Leu 275 tat too ato Tyr Ser Ile 931 979 agt tgg atq aaa Ser Trp Met Lys oto ggo aoc tgg Leu Gly Thr Trp tog Ser 290 tto oto Phe Leu 295 tgg cao ott 000 Trp His Leu Pro gtg Val1 300 otg aog att gtg Leu Thr Ile Val ttc Phe 305 oca otg oto ggg Pro Leu Leu Giy 1027 ttg CCt tta ttt agt gga aat ttc Leu Pro Leu Phe Ser Gly Asn Phe 310 315 ttg ttg acg atc cca gtt gcc gcc Leu Leu Thr Ile Pro Val. Ala Ala 330 ccc atc agc ggt gga. ccc gqc gcg Pro Ile Ser Gly Gly Pro Gly Ala 345 att cac cat ttt tct ggg ggt agg Ile His His Phe Ser Gly Gly Arg 360 365 aag <210> 116 <211> 368 <212> PRT <213> Corynebacterium glutamicum ttg gtg Leu Val 320 agc tac Ser Tyr 335 ttc ag g Phe Arg qga aaa Gly Lys ttc atc gtg acg gtc 1075 Phe Ile Val Thr Val 325 acc: ttc atc gaa. gag 1123 Thr Phe Ile Glu Glu 340 ctg ggg gtc gtt agg 1171 Leu Gly Val Val Arg 355 tgatgaattg gcaccacgtc 1224 1227 <400> 116 Met Ser Thr Gin Ser Tyr 1 Ser His Val1 Ala Tyr Ile Th r His Leu 145 Leu Leu Leu Val2 Leu Phe Leu Ala Met Leu 130 Leu Ile Val1 Gi y Phe Arg Le u Arg Le u 100 Gin Ser Trp Gly His 180 Le u Gin Phe Trp Leu Leu Ile Leu Val1 Gly 165 Al a Arq Thr Asp Arg 70 Ala Phe T yr C ys Leu 150 Ala Leu Ala Ala Ser Phe 55 Arg Arg Ile Trp Val1 135 Asp Val1 Asp His Le u Ala Val Gin Al a Pro Leu Phe Arq 155 Al a Ala Arg Gl y Ser Phe Pro Tyr T rp Met Tyr 140 Pro Trp Asn Gly Val1 As n Phe Val T rp Leu Thr 125 Leu Val Pro Met Phe Leu Ile Al a Gly Ala Ala 110 Gly Val1 Arg T rp Gin 190 Pro Pro Ala Tyr Ala Cys Trp Phe Ala Val Gly Met Ile Ala Ala Giu 195 200 205 Ile Giu Gly Val Arg Phe Pro Arg Val Pro Ser Phe Val Trp Val Gly 210 215 220 Leu Ala Leu Vai Val Ala Trp Ile Ala Gly Gin Glu Trp Phe Gly Pro 225 230 235 240 Leu Gly Leu Val His Pro Ser Pro Trp Giu Phe Asn Leu Arg Val Leu 245 .250 255 Ala Gly Thr Leu Phe Ala Val Phe Leu Val Val Pro Tyr Ala Leu Gly 260 265 270 Thr Pro Ser Arg Leu Leu Asp Ser Ser Trp Met Lys Thr Leu Gly Thr 275 280 285 Trp Ser Tyr Ser Ile Phe Leu Trp His Leu Pro Val Leu Thr Ile Val 290 295 300 Phe Pro Leu Leu Gly Leu Pro Leu Phe Ser Gly Asn Phe Leu Leu Val 305 310 315 320 Phe Ile Val Thr Val Leu Leu Thr Ile Pro Val Ala Ala Ile Ser Tyr 325 330 335 Thr Phe Ile Glu Giu Pro Ile Ser Gly Giy Pro Gly Ala Pro Phe Arg 340 345 350 Leu Gly Val Val Arg Ile His His Phe Ser Gly Gly Arg Ser Gly Lys 355 360 365 <210> 117 <211> 924 <212> DNA <213> Corynebacterium giutainicum <220> <221> CDS <222> (101)..(901) <223> RXA022.50 <400> 117 gtgtttttcq gtgggctqcg atgacgcatg tccaccaaaa qagccacccc ttaaagaaat taaaaagtgg ttttggtagc ttcgcagcaa aatacacatc gtg ggt aac 9ta ttc 115 Val Gly Asn Val Phe 1 tta gaa gtt cct aca gca gta aag cgc gaa gaa qgg gta aac cca aac 163 Leu Glu Val Pro Thr Ala Val Lys Arg Glu Giu Gly Val Asn Pro Asn 15 atc atg aaa aac aac tgg tat cgg ctt ttc aag tat gtg cta att ggc 211 Ile Met Lys Asn Asn Trp Tyr Arg Leu Phe Lys Tyr Val Leu Ile Gly 30 ccg ttt ttg Pro Phe Leu cgt gtg tac aac cgc ccg gag atc gaa Arg Val Tyr Asn Arg Pro Glu Ile Giu ggc Gly aaa gaa aac Lys Giu Asn atc act Ile Pro gca gaa ggt gcc Ala Giu Gly Ala atc atg gcg tcc Ile Met Ala Ser cac gaa gca gtg His Glu Ala Val 259 307 355 403 atg Met gat tcc ttt tat Asp Ser Phe Tyr ttt Ph e 75 ccc ctg ctg tgc Pro Leu Leu Cys cca Pro cgg cag ctg acc Arg Gin Leu Thr cca gcg aag gcc Pro Ala Lys Ala tac ttc aca tca Tyr Phe Thr Ser ggt att aaa ggc Gly Ile Lys Gly aag atg Lys Met 100 cag aag tgg Gin Lys Trp, gca gat aat Ala Asp Asn 120 ttt act tct gtg Phe Thr Ser Val ggg Gly 110 caa gta ccc ctg Gin Val Pro Leu gac cgc acc Asp Arg Thr 115 atg qtg ctg Met Val Leu gcc atg gat tct Ala Met Asp Ser atg aat acc gcc Met Asn Thr Ala gat cgg Asp Arg 135 gqa gac ctc ttc Gly Asp Leu Phe att tac cat gaa Ile Tyr Pro Giu gga Gly 145 tct cqt tcg ccc Ser Arg Ser Pro ga t Asp 150 ggt cgc atc tac Gly Arg Ile Tyr aag Lys 155 ggc aaa acc gga Gly Lys Thr Gly gcc tat gtt gag Ala Tyr Val Ala gaa act ggt acg Giu Thr Gly Thr gtt ata ccc gtt Val Ile Pro Val *atg att ggc agc Met Ile Gly Ser cgg gac Arg Asp 180 gcg aac cat Ala Asn Pro aag gta gga Lys Val Gly 200 atc Ile 185 gga agt tgg ttt Gly Ser Trp Phe ccg Pro 190 aaa ccc gca aaa Lys Pro Ala Lys gtc agg ata Val Arg Ile 195 gaa cat ggg Giu His Gly agc aca att gat Ser Pro Ile Asp ctc gca ttc gtc Leu Ala Phe Val ttg aag Leu Lys 215 cat gga aca tac Pro Gly Thr Tyr gca gag aga aag Ala Ala Arg Lys atg Leu 225 aca gat cac gtt Thr Asp His Val 691 739 787 835 883 atg Met 230 ttc att ctt gat Phe Ile Leu Ala ga t Asp 235 ata act ggt cag Leu Thr Gly Gin tat gtt gat gag Tyr Vai Asp Ala tat aaa gat gtg Sea Lys Asp Val aac gat ctg gag Asn Ala Leu Glu gaa Giu 255 gga aaa gga tac Gly Lys Gly Tyr cag gag Pro Giu 260 ggc aca gct Gly Thr Ala cat tca cag Pro Ser Gin 265 taatcgggtc ttttctgtta aaa <210> 118 <211> 267 <212> PRT <213> Corynebacterium giutamicum <400> 118 Val1 Gly T yr Giu Asn Arg Ile Pro Al a Gly 145 Al a Ile Al a Val1 Leu 225 Tyr Lys Gly Val1 Val1 Gly His Gin Lys Le u Lys 130 Ser Tyr Gly Lys Lys 210 Thr Vali Gly As n As n Le u Lys Gi u Le u Giy Asp 115 Met Arg Val1 Ser Val1 195 Giu Asp Asp Tyr Vai Phe Leu Giu Val Pro Thr Ala Val Lys Pro Ile Giu Ala Thr Lys 100 Arg Val1 Ser Ala Arq 180 Arg His His Ala Pro 260 As n Gly As n Val1 Phe Met Thr Le u Pro Met 165 Asp Ile Gly Val1 T yr 245 Glu Ile Pro Ile Met 70 Pro Gin Ala Asp Asp 150 Giu Al a Lys Le u Met 230 Ser Gi y Lys Leu 40 Al a Ser Lys Trp As n 120 Gl y Arg Gi y Pro Gi y 200 Pro Ile Asp Ala As n 25 Arg Glu Phe Al a Phe 105 Ala Asp Ile Thr Ile 185 Se r Gi y Leu Val1 Pro 265 As n Val1 Gly Tyr Giu Phe Met Leu Tyr Thr 170 Gly Pro Thr Ala Lys 250 Ser Trp T yr Ala Phe Tyr Thr Asp Phe Lys 155 Val1 Ser Ile Tyr Asp 235 As n Gin Arg Arg Ile Leu Thr Val1 Leu 125 Ile Lys Pro Phe Pro 205 Aia Thr Leu Arg Le u Pro Met Leui Ser Gly 110 Met Tyr Thr Val1 Pro 190 Le u Ala Gly Glu <210> 119 <211> 504 <212> DNA <213> Corynebacteriun glutamicum <220> <221> CDS <222> (101)..(481) <223> RXA00607 <400> 119 cactgccagc aacgccaacg gttgaacccg aaccagaagg cgatgaagac tggcccgaac ccatcaaccc cqcaggcgat aacaaagagg aggcaaaccg atg att ctc Met Ile Leu gca ctg Ala Leu 1 .c att !u Ile aca Thr gga Gly aac Asn ttc Phe geC Ala a tg Met gaa Glu gtc Val1 atg Met Ctg Le u ccc Pro ttC Phe ttg Leu cca Pro ctt Leu a tc Ile ctg Leu a cc Thr a cc Thr 9 ca Ala ga t Asp ggt Gly ttc Phe 9CC Al a ctt Le u at C Ile ct g Le u tcg Ser gtc Val1 15 t ca Ser ccc Pro gcc Al a gCg Ala agc Ser act Thr tac Tyr ct g Le u acg Thr qc c Ala atg Met 80 ga c Asp act cag caa Gin Gin 20 cac gca His Ala ggc gaa Gly Glu ctc ccc Leu Pro cg c Arg gCg Al a gcc Al a ca g Gin atc Ile atc Ile gtc aca Thr cgg Arg cgt Thr Ser Ala Arg Ser Val 115 acc aac cca aca qat cag gag gat aaa gct taaatqgcca tqgatgttct. Thr Asn Pro Thr Asp Gin Giu Asp Lys Ala 120 125 cct <210> 120 <211> 127 <212> PRT <213> Corynebacterium giutamicum <400> 120 Met Ile Leu Ala Leu Thr Val Ala Ile Leu Phe Gly Gly Gly Val Tyr 1 5 -10 Leu Ile Gin Gin Arq Gly Met Val Arg Ile Val Phe Gly Met Ser Leu 25 Ile Trp Asp Ala Asp Se r Gly Arg Pro Thr Thr Al a His Ala Gly Glu Leu Pro Thr Thr Arg Ser 100 Arq Ser 115 As n Phe Al a 70 Met Glu Thr Leu Pro 55 Phe Le u Pro Asn Thr 40 Asp ValI Ala Asp Pro 120 Ile Arg Le u Le u Asp 105 Thr Ala Leu Ile Leu Ser Glu Gi y Thr Val1 Gly Pro Asp 125 Pro Al a Al a Ser Thr Al a Thr Al a Met Asp Thr <210> 121 <211> 1119 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1096) <223> RXA02397 <400> 121 gtgtgaataa aacttgtttc ctggtcattt cectactga actgcgetta tgcctatgct tagaaaccag agaeaagctt aagaaggaca ggggccggcc atq aat qat ttc gaa aca Thr cgc Arg acc Thr cag Gin get Ala aag Lys acc Thr gtg Val1 ace Thr ctc Leu tea Ser ctc Leu cqg Arg ttc Phe ggt Gly gcg Al a eet Pro cgc Arg tet Ser gtg Val1 t eq Ser gga Gly aee Thr gat Asp aaa Lys gaa Glu ttg Leu ace Thr ttt Phe t Se r eaa Gln gta Val1 ate Ile ggg Gly geg Ala tgg T rp As n gea Al a eta Le u ct t Le u Leg S er age Ser LLL Phe Asp gce Ala cee Pro gat Asp aea Thr ctg Le u ggg Gly Glu age Ser Ltg Leu gta Val1 aat Asn 9ge Gly eag Gin ect tct gaa Pro Ser Giu att ttt tat Ile Phe Tyr 120 act Thr 105 gcg eac ccg cta Ala Hius Pro Leu atc get atc cct Ile Ala Ile Pro gag att gag Giu Ile Giu 115 gac gcc gtg Asp Ala Vai eag cac ace gat Gin His Thr Asp gtg Val 125 gag cog gga agc Giu Pro Gly Ser gcg ceg Ala Pro 135 gac ttt cag gaa Asp Phe Gin Glu eag gat atg tgg Gin Asp Met Trp cge Arg 145 agg cgt etc gga Arg Arg Leu Gly gtc ace gaa cca Val Thr Giu Pro aac As n 155 ctt ata tat aaa Leu Ile Tyr Lys ttt tee gga ec Phe Ser Gly Pro aaa geg eag egt Lys Ala Gin Arg gta gaa atg ctg Val Giu Met 'Leu aat etg tgg aag Asn Leu Trp Lys ate gge Ile Giy 180 gtg gtg gtg Vai VIal Val gaa tac ace Glu Tyr Thr 200 agt Se r 185 agg aat aeg gaa Arg Asn Thr Giu agt Ser 190 egc ctt ggg tta Arg Leu Gly Leu act egt gtg Thr Arg Vai 195 atg teg gag Met Ser Glu cee ace ect gge Pro Thr Pro Gly gta eec gtg ceg Val Pro Val Pro otg Leu 210 aag aac Lys Asn 215 tgt tgg tac age Cys Trp Tyr Ser cgg gtg tot gaa Arg Vai Ser Giu ace Thr 225 att ggt gag aae Ile Giy Giu Asn ca g Gin 230 gtt cog gaa att Vai Pro Giu Ile gtg Val1 235 cge tgc tta ggc Arg Cys Leu Giy att ttc tgt ggc Ile Phe Cys Giy ett ccc cag atg Leu Pro Gin Met etc aaa gaa eca Leu Lys Giu Pro aag gee ggc aag Lys Ala Gly Lys ttg ega Leu Arg 260 ate eaa qaa Ile Gin Giu ott too eca Leu Ser Pro 280 tog Ser 265 gaa goa gca geg Giu Aia Ala Ala tat T yr 270 ate qeg atg gcg Ile Ala Met Ala ega eta gat Arg Leu Asp 275 tat att too Tyr Ile Ser 931 979 ego ace ggo aae Arg Thr Giy Asn ace Thr 285 act tgq aco aao Thr Trp Thr Asn aeg egt Thr Arg 295 cot etc tee ec Pro Leu Ser Pro ttt agg tgg gao Phe Arg Trp Asp gt g Val1 305 gtg otg gag get Vai Leu Giu Ala eac eaa ttg gag His Gin Leu Giu aac As n 315 etg ctg egt gga Leu Leu Arg Gly ga e Asp 320 aca ggg cog gte Thr Gly Pro Val 1027 1075 1119 gee aca caa tog Ala Thr Gin Ser gca get ggt Ala Ala Gly 330 taacoaaaag ttoacgtgga gat (210> 122 <211> 332 <212> PRT <213> Corynebacterium glutamicum <400> 122 Met Asn Asp Phe Glu Thr Thr I Pro Al a Le u Ala Thr Ser Ile Ser Arg 145 Ph e Le u Gly Pro Thr 225 Ile Ala Met Asn Ala Leu Leu Ser Ser Phe Pro Asp 130 Arg Ser Trp Leu Leu 210 Ile Phe Gly Al a Ser Al a Pro Asp Thr Le u Gly Glu 115 Asp Arg Gly Lys Th r 195 Met Gly Cys Lys Arg 275 Tyr Arg As n Ala Ser Ile Phe 100 Ile Al a Leu Pro Ile 180 Arg Ser Giu Gly Le u 260 Leu Ile 5 Ser Leu Val Asn Gly Gin Giu Val Gly Gly 165 Giy Val1 Glu Asn Tyr 245 Arg Asp Ser Arg Thr Gin Al a 70 Lys Pro Ile Al a Ser 150 Lys Val1 Glu Lys Gin 230 Leu Ilie Leu Thr Val1 Thr Le u 55 Ser Leu Ser Phe Pro 135 Val Al a Val1 Tyr Asn 215 Val1 Pro Gin Ser Arg Ile Asp Arg 10 Giu Gin Phe 25 Lys Gin Gly 40 Ala Asp Ala Ser Leu Pro Asp Val Arg 90 Giu Thr Ala 105 Tyr Gin His 120 Asp Phe Gin Thr Giu Pro Gin Arg Ala 170 Val Ser Arg 185 Thr Pro Thr 200 Cys Trp Tyr Pro Glu Ile Gin Met Trp 250 Glu Ser Giu 265 Pro Arg Thr 280 Pro Leu Ser Ile Ile Al a Al a Asp 75 Ser His Thr Giu As n 155 Val1 As n Pro Ser Val1 235 Leu Al a Gly Pro Se r Val Ser Gly Thr Asp Pro Asp Asn 140 Leu Giu Thr Gly Ile 220 Arg Lys Al a As n Ala Lys Giu Leu Thr Ph e Se r Le u Val1 125 Gin Ile Met Glu Glu 205 Ar g Cys Giu Ala Thr 285 Phe Glu Thr Ala Lys Asp Glu Met 110 Giu Asp Tyr Le u Ser 190 Val1 Val1 Leu Pro Tyr 270 Thr Arg Gin Asp Val Arg Ile Gin Giy Gly Ala Leu Trp Arg Ile Ala Pro Gly Met Trp Lys Glu 160 Gly Asn 175 Arg Leu Pro Val Ser Glu Gly Giu 240 Val Lys 255 Ile Ala Trp Thr Trp Asp 290 295 300 Val Val Leu Giu Ala Ser His Gin Leu Glu Asn Leu Leu Arg Gly Asp 305 310 315 320 Thr Gly Pro Val Thr Ala Thr Gin Ser Ala Ala Giy 325 330 <210> 123 <211> 1462 (212> DNA (213> Corynebacterium giutaniou <2 <221> CDS (222> (101)..(1462) <223> RXN03110 <400> 123 aatgagtgaa cctgogcttg aactatacco cctggggtat ccqaggggta tctagttttt acgttgagaa ggagagctca tactgtagat tctcaatacc atc Ile qcc Ala tat Tyr ga a Gi u gct Ala tgg Trp ogc Arg ccg Pro oca Pro gac Asp aac Asn gao Asp cat' His act Thr tat Tyr gga Giy oac His 120 tto Phe ga a Glu ac Thr atg Met atc Ile aat As n gaa Glu aat Asn 105 tta Leu atg Met ott Le u gt 0 Val aag Lys gcg Ala aco Thr gac Asp gtg Val1 ttc Phe act Thr cag Gin gt t Val aac Asn tat Tyr tao Tyr gag Glu aca Thr ct g Leu 125 gat Asp gcc Ala ga t ASP 30 99a Gly ttg Leu gt c Val1 cga Arg got Al a 110 aag Lys ttC Phe gt g Val1 1 ttc Phe 090 Ar g att Ile acc Thr gag Giu gao Asp acc Thr gcg Al a 909 Al a 145 ott att gaa ogo Leu Ile Glu Arq ggo Gi y att Ile gga Gly gag Glu ggc Gly ago Se r gg o Gi y 115 goa Al a ga t Asp t go Cys gc Al a gtt Val1 tta Leu gc Al a gag Giu 100 oat His gat Asp ott Leu cga Arg 150 cca qat ttg ctc Pro Asp Leu Leu qaa gca gct ggg Glu Ala Ala Gly ga Gly 160 gtg gac act cgt Val Asp Thr Arg gag ggg gct cgc Giu Giy Ala Arg caa Gin 170 atg ttc aag agc Met Phe Lys Ser aag gaa aaa ttc Lys Giu Lys Phe ctg aca Leu Thr 180 ttg cct gat Leu Pro Asp tgt ggc aaa Cys Gly Lys 200 atc cag atc ttc Ile Gin Ile Phe cct Pro 190 ggt cat ggt tcc Gly His Gly Ser ggt tcc gcg Gly Ser Ala 195 gga tat gaa Gly Tyr Glu gcc ttg ggt tcg Ala Leu Gly Ser cct tca aca aca Pro Ser Thr Thr cgt caa Arg Gin 215 ttt gcg tgg tgg Phe Ala Trp Trp gga Gly 220 aag tat ctg gag Lys Tyr Leu Giu gca Ala 225 gat gat gaa caa Asp Asp Giu Gin gqa Gly 230 ttc att gat gag Phe Ile Asp Giu ctg gaa ggc caa Leu Glu Gly Gin gat gca cct gca Asp Ala Pro Ala tac T yr 245 ttc ggc agg atg Phe Gly Arg Met agg caa aat agg Arg Gin Asn Arg caa Gin 255 ggg ccc gca att Gly Pro Ala Ile atq ggc Met Gly 260 gct cgc gag Ala Arg Giu att. gtt gtt Ile Val Val 280 ctg Leu 265 ttg cca caq ctq Leu Pro Gin Leu gct tct gat ctg Ala Ser Asp Leu cac gac gtc His Asp Val 275 gqc act gta Gly Thr Val gat acc cgc tca Asp Thr Arg Ser gcc Ala 285 gat gaa gtt cac Asp Giu Vai his cag Gin 290 gct ggt Ala Giy 295 gca gtg aat att Ala Val Asn Ile c ct Pro 300 gcg ggc aat tcg Ala Gly Asn Ser gcg aaa ttt ggc Ala Lys Phe Gly tgg acc gtt gat Trp Thr Val Asp gag aag gat tc Giu Lys Asp Ser gct ttg gtt Ctg Ala Leu Vai Leu Ctc Leu 325 gcg gca agc caa Ala Ala Ser Gin ggt gcc atg gag Gly Ala Met Giu atg Met 335 tgg gac cac atg Trp Asp His Met gtt cgc Val Arg 340 1027 1075 1123 1171 1219 qtg gga atc Vai Gly Ile gac cta gtt Asp Leu Val 360 gat Asp 345 aat gtt gct ggt Asn Val Ala Gly atc acc aac ttt Ile Thr Asn Phe gat ggg gtg Asp Gly Val 355 gat gaa ttg Asp Glu Leu gca ccg caa act Ala Pro Gin Thr gtg Val1 365 tcc cca gat cag Ser Pro Asp Gin ctg Leu 370 gaa tac Giu Tyr 375 gat cta ctt ctt Asp Leu Leu Leu gtc cgc aac cgc Val Arg Asn Arg gaa gtc gaa gaa Giu Val Glu Glu 1267 ggc tac Gly Tyr 390 aat ctg Asn Leu agt qga Ser Gly ttt gat Phe Asp atc Ile gag Glu aca Th r gtg Val1 440 cca gga gca Pro Gly Ala 395 aaa ctg cca Lys Leu Pro 410 cgc agc tca Arg Ser Ser 425 gtg gaa ctt Val Glu Leu cat His ga c Asp gcc Al a att aat Ile Asn gga aaq Gly Lys gca Ala 430 t cc Ser 415 a gc Ser tat Tyr ggt gca tcc Gly Ala Ser 400 atc qtg aqc Ile Val Ser acc ctg cgt Thr Leu Arg gac aac tgg Asp Asn Trp 450 gtg Val1 t ac Tyr aat Asn 435 gtc Val1 ctg tgg Leu Trp 405 tgc aag Cys Lys 420 gct ggt Ala Gly cgg cac Arg His 1315 1363 1411 1459 caa gga Gin Gly 445 aac Asn <210> 124 <211> 454 <212> PRT <213> Corynebacterium giutamicum 1462 <400> 124 Val Leu Ile Glu 1 Phe Arg Ile Thr Glu Asp Thr Ala Ala 145 Val1 Glu Ile Asp Val1 Ar g Gly Gly Pro Phe 130 Gly Asp Lys Gly Ile Gly Glu Gly Ser Cl y 115 Al a Asp Thr Phe Arg 5 Gin Val1 Th r Ala Asp Ile Thr Gl u Ci y Phe 165 Thr Ile Tyr Asp Glu His Leu Thr 55 Al a Gln Leu Glu Gly 135 Pro Giy Pro As n Asp 40 His Thr Tyr Gly His 120 Ph e Asp Al a Asp Thr Met Ile Asn Giu Asn 105 Leu Met Leu Arg His Asp 10 Ala Ala His Ala Phe 90 Leu Ser Leu Leu Gin 170 Ile Leu Val L ys Ala Thr 75 Asp Val1 Phe Thr Asp 155 Met Gln Al a ValI Lys Asp Met Ala Le u Leu Gly 140 Glu Phe Ile Gin Val1 As n Tyr Tyr Giu Thr Leu 125 Asp Ala Lys Pbie Ser Pro Met Ser Ser Ile Val1 Asp Vai Giy Leu 175 Gly Tyr Ar g Gl u Cl y GI y Cys His Gl y Phe Gl y 160 Lys His Gly Ser Gly 195 Thr Leu Gly 210 Ala Asp Asp 225 Asp Ala Pro Pro Ala Ile Asp Leu His 275 His Gln Gly 290 Met Ala Lys 305 Ala Leu Val Asp His Met Asn Phe Asp 355 Gin Leu Asp 370 Ser Glu Val 385 Ala Ser Val Val Ser Tyr Leu Arg Asn 435 Asn Trp Val 450 <210> 125 <211> 1023 <212> DNA Ser Ala Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr T yr Glu Al a Met 260 Asp Thr Phe Leu Val 340 Gly Glu Glu Leu Cys 420 Ala Arg Gl u Gin Tyr 245 Gly Val1 Val1 Gi y Le u 325 Arg Val1 Le u Gi u Trp 405 Lys Gly His Arg Gly 230 Phe Al a Ile Ala Ser 310 Al a Val1 Asp Glu Gly 390 As n Ser Phe Asn Gin 215 Phe Gly Arg Val1 Gly 295 Trp Ala Gly Leu Tyr 375 Tyr Leu Gly Asp 200 Phe Ile Arg Glu Val1 280 Al a Th r Ser Ile Val1 360 Asp Ile Glu Thr Val1 440 Al a Asp Met Leu 265 Asp ValI ValI Gin Asp 345 Ala Leu Pro Lys Arg 425 ValI Trp Glu Lys 250 Leu Thr As n Asp Ile 330 As n Pro Le u Gly Leu 410 Ser Giu Trp Leu 235 Arg Pro Arg Ile Pro 315 Gly ValI Gin Leu Ala 395 Pro Ser Le u 205 Lys Gi u As n Le u Al a 285 Al a Ly s Met Gi y Val1 365 Val1 His Asp Al a Gi y 445 Tyr Gly Arg Glu 270 Asp Gly Asp Glu Phe 350 Ser Arg Ile Gly Al a 430 Se r Le u Gin Gin 255 Ala Glu Asn Ser Met 335 Ile Pro Asn Asn Lys 415 Ser Tyr Glu Pro 240 Gi y Ser Val1 Ser Arg 320 Trp Thr Asp Arg Gly 400 Ile Th r Asp <213> Corynebacteriun glutamicum <220> <221> CDS <222> (1023) <223> FRXA00660 <400> 125 cca ggc cat acc cog Pro Gly His Thr Pro 1 5 gaa cac tta tcg Giu His Leu Ser ttc Phe 10 ctg ctg aag gac Leu Leu Lys Asp ggc gcg Gly Ala ttc gca cat Phe Ala His ggt gat ott Gly Asp Leu 35 gag Giu cca gga ttc atg Pro Gly Phe Met act ggc gat ttc Thr Gly Asp Phe gtt ttc gcg Val Phe Ala ggg gga gtg Gly Gly Val ggc cga cca gat Gly Arg Pro Asp ttg Leu 40 ctc gat qaa gca Leu Asp Giu Ala got Ala gac act Asp Thr cgt ttt gag ggg Arg Phe Glu Gly cgc caa atg ttc Arg Gin Met Phe ago ttg aag gaa Ser Leu Lys Giu tto otg aca ttg Phe Leu Thr Leu gat cac ato cag Asp His Ile Gin tto cot ggt oat Phe Pro Gly His too ggt too gog Ser Gly Ser Ala tgt Cys ggc aaa goc ttg Gly Lys Ala Leu gg t Gly 90 tog gtt cot toa Ser Val Pro Ser aca aca Thr Thr 192 240 288 336 384 ott gga tat Leu Gly Tyr gat gat gaa Asp Asp Giu 115 gaa Giu 100 ogt oaa tit gog Arg Gin Phe Ala tgg gga aag tat Trp Giy Lys Tyr otg gag gca Leu Giu Ala 110 caa cot gat Gin Pro Asp caa gga ttc att Gin Giy Phe Ile ga t Asp 120 gag ott otg gaa Giu Leu Leu Glu ggc Gly 125 gca cot Ala Pro 130 gca tac tto ggc Ala Tyr Phe Gly agg Arg 135 atg aag agg oaa Met Lys Arg Gin aa t As n 140 agg oaa ggg coo Arg Gin Gly Pro att atg qg got Ile Met Giy Ala gag otg ttg oca Glu Leu Leu Pro otg gaa got tot Leu Giu Ala Ser ctg cac gao gto Leu His Asp Val gtt gtt gat acc Val Vai Asp Thr tca gcc gat gaa Ser Ala Asp Giu gtt cac Val His 175 cag ggo act Gin Gly Thr gog aaa ttt Ala Lys Phe 195 gta Val1 180 got ggt goa gtg Ala Gly Ala Val aat Asn 185 att cot gog ggc Ile Pro Ala Gly aat tog atg Asn Ser Met 190 too oga got Ser Arg Ala ggc tog tgg aco Gly Ser Trp Thr gat ccc gag aag Asp Pro Giu Lys ttg gtt Leu Vai 210 otg oto gog gca Leu Leu Ala Ala a go Ser 215 caa att ggt gc Gin Ile Gly Aia gag atg tgg gao Giu Met Trp Asp cac atg gtt ogo gtg gga ato gat aat gtt got ggt ttt ato aco aao His Met Val Arg Val. Gly Ile Asp Asn Val. Ala Gly Phe Ile Thr Asn 225 230 235 240 ttt gat ggg gtg gac cta gtt gca ccg caa act gtg tcc cca gat cag 766 Phe Asp Gly Val. Asp Leu Val. Ala Pro Gin Thr Val Ser Pro Asp Gin 245 250 255 ctg gat gaa ttg gaa tac gat cta ctt ctt gat gtc cgc aac cgc agt 816 Leu Asp Giu Leu Giu Tryr Asp Leu Leu Leu Asp Val Arg Asn Arg Ser 260 265 270 gaa gtc gaa qaa ggc tac atc cca gga gca ctc cat att aat qgt gca 864 Giu Vai Giu Giu Gly Tyr Ile Pro Giy Aia Leu His Ii.e Asn Gly Aia 275 280 285 tcc qtg ctg tgg aat ctg gag aaa ctg cca cgt gac gga aag atc gtg 912 Ser Val. Leu Trp Asn Leu Giu Lys Leu Pro Arg Asp Giy Lys Ile Val. 290 295 300 agc tac tgc aag agt gga aca cqc agc tca atc gcc gca agc acc ctg 960 Ser Tyr Cys Lys Ser Giy Thr Arg Ser Ser Ile Aia Ala Ser Thr Leu 305 310 .315 320 cgt aat qct ggt ttt gat gtg gtg gaa ctt caa gga tcc tat gac aac 1008 Arq Asn Aia Gly Phe Asp Vai Va]. Giu Leu Gin Giy Ser Tyr Asp Asn 325 330 335 tgg gtc cgg cac aac 1023 Trp Val Arg His Asn 340 <210> 126 <211> 341 <212> PRT <213> Corynebacterium giutarnicum <400> 126 Pro Giy His Thr Pro Giu His Leu Ser Phe Leu Leu Lys Asp Gly Ala 1 5 10 Phe Ala His Giu Pro Gly Phe Met Leu Thr Giy Asp Phe Val Phe Ala 25 Giy Asp Leu Giy Arg Pro Asp Leu Leu Asp Giu Ala Ala Giy Gly Va]. 40 Asp Thr Arg Phe Giu Giy Ala Arg Gin Met Phe Lys Ser Leu Lys Giu 55 Lys Phe Leu Thr Leu Pro Asp His Ile Gin Ile Phe Pro Gly His Gly 70 75 Ser Gly Ser Ala Cys Gly Lys Ala Leu Giy Ser Val. Pro Ser Thr Thr 90 Leu Giy Tyr Giu Arq Gin Phe Ala Trp Trp Giy Lys Tyr Leu Giu Ala 100 105 110 Asp Asp Giu Gin Giy Phe Ilie Asp Glu Le'u Leu Giu Gly Gin Pro Asp 115 120 125 Ala Pro Ala Tyr Phe Gly Arg Met Lys Arg Gin Asn Arg Gin Gly Pro 130 135 140 Ala Ile Met Gly Ala Arg Glu Leu Leu Pro Gin Leu Giu Ala Ser Asp 145 150 155 160 Leu His Asp Val Ile Val Val Asp Thr Arg Ser Ala Asp Glu Val His 165 170 175 Gin Gly Thr Val Ala Gly Ala Val Asn Ile Pro Ala Gly Asn Ser Met 180 185 190 Ala Lys Phe Gly Ser Trp Thr Val Asp Pro Giu Lys Asp Ser Arg Ala 195 200 205 Leu Val Leu Leu Ala Ala Ser Gin Ile Gly Ala Met Giu Met Trp Asp 210 215 220 His Met Val Arg Val Gly Ile Asp Asn Val Ala Gly Phe Ile Thr Asn 225 230 235 240 Phe Asp Gly Val Asp Leu Val Ala Pro Gin Thr Val Ser Pro Asp Gin 245 250 255 Leu Asp Giu Leu Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg Ser 260 265 270 Giu Val Glu Glu Gly Tyr Ile Pro Gly Ala Leu His Ile Asn Gly Ala 275 280 285 Ser Val Leu Trp Asn Leu Giu Lys Leu Pro Arg Asp Gly Lys Ile Val 290 295 300 Ser Tyr Cys Lys Ser Gly Thr Arg Ser Ser Ile Ala Ala Ser Thr Leu 305 310 315 320 Arg Asn Ala Gly Phe Asp Val Val Giu Leu Gin Gly Ser Tyr Asp Asn 325 330 335 Trp Val Arg His Asn 340 <210> 127 <211> 756 <212> DNA <213> Corynebacterium glutamicur <22 0> <221> CDS <222> (733) <223> RXA00801 <400> 127 ggataagttt gtttctgaqc qtattqgtct tgatgatgtt gaagaggctt tcaacaccat gaaggctggc gacqtgctgc gttctgtqgt ggaqatctaa atq gct cac gac gga 115 Met Ala His Asp Gly 1 ttg cgc gta gaa aac att gtc acc tca Leu Arg Val Glu As n Ile Val Thr Ser ggc Gly i5 atc ttt gcc ctt Ile Phe Ala Leu gat ggt Asp Gly ggc gaa tgg Gly Giu Trp gag gtt ttc Gin Val Phe gtc gac aac aac Val Asp Asn Asn tgg gtt gtg gga Trp Val Vai Gly aat gat gat Asn Asp Asp atc atc gag Ile Ile Glu atc atc gat gcg gca cac act gca gca Ile Ile Asp Ala Ala His Thr Ala Ala gct gtc Ala Val ggt gga cgt gct Gly Giy Arg Ala aag ggc att ttg Lys Gly Ile Leu tgc Cys acc cac gca cac: Thr His Ala His aa t As n gac cac atc act Asp His Ile Thr gt C Val1 gca cca gag cta Ala Pro Gin Leu aag gaa ttt gat Lys Gin Phe Asp 259 307 355 403 451 cca atc ttc gtg Pro Ilie Phe Val cca ggt gac caa Pro Gly Asp Gin ctg tgg gag gaa Leu Trp Gin Gin acc cac Thr His 100 gga aac ctg Gly Asn Len gct gga act Ala Gly Thr 120 acc Thr 105 cac gag gat ttg His Gin Asp Len gca Al a 110 gat cag cag aag ttc caa atc Asp Gin Gin Lys Phe Gin Ile 115 gaa ctg atc gtg Gin Len Ile Val aat acc cct gga Asn Thr Pro Giy tca cct gga Ser Pro Gly tcc agc Ser Ser 135 tgc ttc tac ctc Cys Phe Tyr Leu Cct Pro 140 gaa gca aac gag Gin Ala Asn Gin ctc Len 145 ttc tct gga gac Phe Ser Gly Asp ttg tcc cag ggt Len Phe Gin Giy ccg gga gca act Pro Gly Ala Thr cgt aag tac agc Arg Lys Tyr Ser tcC Se r 165 ttt gac acc atc Phe Asp Thr Ile att Ile 170 gag tcc ctc aag Gin Ser Len Lys acc Thr 175 tca att ttg gat Ser Ile Len Asp cta cca Len Pro 180 gcg gaa acc Ala Gin Thr gct gag gct Ala Gin Ala 200 gtg cqc act ggc Val Arg Thr Gly ggt gat cac acc Giy Asp His Thr agt gtg ggg Ser Val Gly 195 cca cac ttg gag Pro His Len Gin gaa Gin 205 tgg att aaa cgc Trp Ile Lys Arg ggg cac 733 Gly His 210 taagccccga acgattagta ggc <210> 128 <211> 211 <212> PRT (213> Corynebacterinrn glntamicnm (400> 128 Met Ala His Asp Gly Len Arq Val Gin Asn Ile Val Thr Ser Gly Ile 1 5 10 Phe Ala Len Asp Gly Gly Gin Trp Giu Val Asp Asn Asn Ile Trp Vai 25 Val Gly Asn Asp Asp Gin Val Phe Ile Ile Asp Ala Ala His Thr Ala 40 Ala Pro Ile Ile Gin Ala Val Gly Gly Arg Ala Val Lys Giy Ile Leu 55 Gys Thr His Ala His Asn Asp His Ile Thr Val Ala Pro Gin Len Ser 70 75 B0 Lys Giu Phe Asp Ala Pro Ile Phe Val His Pro Gly Asp Gin Met Len 90 Trp Gin Giu Thr His Gly Asn Len Thr His Giu Asp Len Ala Asp Gin 100 105 110 Gin Lys Phe Gin Ile Ala Giy Thr Gin Len Ile Val Leu Asn Thr Pro 115 120 125 Gly His Ser Pro Gly Ser Ser Cys Phe Tyr Leu Pro Giu Ala Asn Giu 130 135 140 Leu Phe Ser Gly Asp Thr Len Phe Gin Gly Gly Pro Gly Ala Thr Gly 145 150 155 160 Arg Lys Tyr Ser Ser Phe Asp Thr Ile Ile Gin Ser Leu Lys Thr Ser 165 170 175 Ile Len Asp Len Pro Ala Gin Thr Thr Val Arg Thr Gly His Gly Asp 180 185 190 His Thr Ser Vai Gly Ala Giu Ala Pro His Len Gin Gin Trp Ile Lys 195 200 205 Arg Giy His 210 <210> 129 <211> 966 <212> DNA <z213> Corynebacterium glntamicnm <220> <221> CDS <222> (101)..(943) <223> RXA00821 <400> 129 ttaaaagctt gcttctcgac gcaaaaaccc atccqgcqca tcccttcaat gttaggggtg cgctgctatt tttctcccca gttctacgaa. atgacttatt gtg act aag ctt gag 115 Val Thr Lys Len Gln 1 cgc atq gag cat cct gct tac agc caa ttg cgg ccg gtt acc ccg toc 163 Arg Met Giu His Pro Ala Tyr Ser Gin Leu 15 Arg Pro Vai Thr Pro Ser gca tct gtt Ala Ser Val act aat tct Thr Asn Ser ttg tgc cct aat Leu Cys Pro Asn ggt tac agc tcg Gly Tyr Ser Ser ctg gaa ggc Leu Glu Gly agc att gtc Ser Ile Val 211 259 tgg gtt atc cgg Trp Val Ile Arg 008 gaa gao ccc Pro Giu Asp Pro atc gat Ile Asp cca ggt cct gaa Pro Gly Pro Giu gat Asp 60 gag ggc cac ctt Glu Giy His Leu aac gtc ttg Asn Vai Leu cac cgt cac His Arg His gct gag gag gtg Ala Giu Giu Val ttg att ott ctg Leu Ile Leu Leu cat tcc His Ser tat gat Tyr Asp cct gtg Pro Val 100 307 355 403 cat gct gao ggc His Ala Asp Gly gca Ala cag cgt ttc cgt Gin Arg Phe Arg cag Gin 95 otg aco aat gca Leu Thr Asn Ala cgt gog atg Arg Ala Met ggt gag atc Gly Giu Ile 120 gao Asp 105 cot tog tao tgt Pro Ser Tyr Cys ggt gog gag gag Gly Ala Giu Giu att oat gat Ile His Asp 115 gag gtg gtg Giu Val Val 451 499 ato aog ato gao Ile Thr Ile Asp ggt Gly 125 gto 800 coa oag Val Thr Pro Gin att Ile 130 gce aca Ala Thr 135 oct ggt cat ace Pro Gly His Thr gat tct gtg tot Asp Ser Val Ser ttc atc tgg agt Phe Ile Trp Ser gga. Gly 150 gtc cot cat gag Vai Pro His Giu too Ser 155 aot ttg gag ggo Thr Leu Giu Gly ato Ile 160 gtt tot ggc gao Val Ser Gly Asp 547 595 643 att gog ggt cgt Ile Ala Gly Arg 800 acg atg att Thr Thr Met Ile gag 800 gac ggc Giu Thr Asp Gly gat ttg Asp Leu 180 qqt gag tac Gly Giu Tyr att cog otg Ile Pro Leu 200 otg Leu 185 aat tot ttg gc Asn Ser Leu Ala ttg gag gag ogo Leu Giu Glu Arg ggc aag gat Giy Lys Asp 195 gtg too too Val Ser Ser ott oca gga oat Leu Pro Gly His ggt Gly 205 008 gat gga oag Pro Asp Gly Gin gao Asp 210 ttc gog, Phe Ala 215 ogt aag tao att Arg Lys Tyr Ile ogt cgt gag otg Arg Arg Giu Leu otg aao cag ato Leu Asn Gin Ile gag gta tgg gag Giu Val Trp Giu 800 Thr 235 ogt ggc cgt gao Arq Gly Arg Asp gtg Val1 240 too atg aag gat Ser Met Lys Asp ato gao goc ato tao gat gat gtt gat 008 gtt otg ogt ggt goa goo Ile Asp Ala Ile Tyr Asp Asp Val Asp Pro Val Leu Arg Gly Ala Ala gag cag tcc Giu Gin Ser tcc gcc tca Ser Ala Ser 280 250 255 260 act cat gtg gct att cgt tac ctg cag gct cag gaa gct Thr His Vai Ala Ile Arq Tyr Leu Gin Ala Gin Giu Ala 265 270 275 aac taaacacttt taactaaaca aca Asn (210> 130 <211> 281 <212> PRT <213> Corynebacterium giutamicum <400> 130 Val Thr Lys 1 Pro Vai Thr Ser Ser Leu Pro Arg Ser Asn Vai Leu His Arq His Thr Asn Ala Giu Giu Ile 115 Gin Ilie Giu 130 Tyr Phe Ile 145 Val Ser Giy Thr Asp Gly Glu Arg Giy 195 Gin Asp Val 210 Arg Leu Asn 225 Leu Giu Arg 5 Pro Ser Ala Giu Gly Thr Ile Val Ile His Ser Lys 70 Tyr Asp His Pro Val Arg 100 His Asp Gly Val Val Ala Trp Ser Gly 150 Asp Thr Ile 165 Asp Leu Gly 180 Lys Asp Ile Ser Ser Phe Gin Ile Arg 230 Met Glu His Ser Asn Asp 55 Ala Al a Al a Glu Thr 135 Val1 Ala Glu Pro Al a 215 Glu Val1 Ser 40 Pro Giu Asp Met Ile 120 Pro Pro Gly Tyr Leu 200 Arg Val Pro 10 Leu Val1 Pro Val Al a 90 Pro Thr His Giu His 170 As n Pro Tyr Glu Al a Cys Ile Glu Gi y 75 Gin Ser Ile Thr Ser 155 Th r Ser Gly Ile Thr 235 Tyr Pro Arq Asp Leu Arg Tyr Asp Arg 140 Thr Thr Le u His Giu 220 Arg Ser Asn Ala Gi u Ile Ph e Cys Gly 125 Asp Leu Met Ala Gly 205 Arg Gly Gin Pro Pro Gi y Le u Arg Ala 110 Val1 Se r Glu Ile Ile 190 Pro Arg Arg Leu Gly Giu His Leu Gin Gly Thr Val Gly Ser 175 Leu Asp Giu Asp Arg Tyr Asp Leu Thr Leu Al a Pro Se r Ile 160 Gi u Gi u Gly Leu Val1 240 Ser Met Lys Asp Leu Ile Asp Ala Ile Tyr Asp Asp Val Asp Pro Val 245 250 255 Leu Arg Gly Ala Ala Giu Gin Ser Thr His Val Ala Ile Arg Tyr Leu 260 265 270 Gin Ala Gin Giu Ala Ser Ala Ser Asn 275 280 <210> 131 <211> 1530 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(1507) <223> RXN02966 <400> 131 aaatataccc cccagggtat ottgacagat taaagctcga tgttttaggc tctacatata cccccacggg tatcccctca actttgatct aagqtgtoac atg ctt ttt gaa cyc Met Leu Phe Glu Arq atc Ile cgc Arg tat Tyr gaa Glu got Al a tgg T rp aaq Lys cca Pro ccc tao Tyr gaa Glu Ctg Leu acc Thr gc Ala caa Gin ctg Le u gag Giu ggt gaa Gl u Gly gac Asp cat His a cc Thr tat Tyr gga Gly cac His 120 ttt gg9C Gly gcg Ala gca Ala cat His gcc Al a ttt Phe atc Ile t ca Ser ctc ctc Leu att Ile gca Al a gc Ala gag Glu aca Thr acc Thr ttt Phe agc gcc Ala gtt Val aaa Lys ga t Asp 60 att Ile ggc Gly atc Ile ttg Le u ggt gcc Al a ga t Asp aac As n ct 0 Le u ctc Le u acc Thr gcc Ala 110 act Thr ttC ago S er 15 got Ala a tg Met tcc Ser tot Ser t tg Leu aag Lys ga t Asp gtc 1 tto Phe oga Arg att Ile act Thr gaa Giu cac His act Thr gog Ala gta ggo Gi y ato Ile gc Ala qaa Glu gga Gly too Ser gga Gly 115 t ca. Ser gac 115 163 211 259 307 355 403 451 499 547 Pro Gly 135 Phe Met Leu Ser Asp Phe Val Phe Gly Asp Val Gly cg t Arg 150 cca gat tta ctt Pro Asp Leu Leu gat Asp 155 gag goa gct ggc Giu Ala Ala Gly ggc Gl y 160 qtg gac acc cgc Val Asp Thr Arg gcc gga gca cag Ala Gly Ala Gin otc ttc cat agc Leu Phe His Ser aaa gag cag ttc Lys Glu Gin Phe ctt gca Leu Ala 180 ctc ccc gac Leu Pro Asp tgt ggc aag Cys Gly Lys 200 att cag gtt tat Ile Gin Val Tyr cca Pro 190 ggt cat ggt gct Gly His Gly Ala ggc agc cct Giy Ser Pro 195 gga tat gaa Gly Tyr Glu 691 739 gca ttg ggc gcg Ala Leu Gly Ala cot agc acc aco Pro Ser Thr Thr aag gct Lys Ala 215 aat gcg tgg tgg Asn Ala Trp Trp gct Ala 220 cca tat ctg cgc Pro Tyr Leu Arg agt Ser 225 gat gat gaa gcc Asp Asp Glu Ala ggo Giy 230 ttt gtg gaa gag Phe Val Giu Giu ctc gao ggc cag Leu Asp Gly Gin cca Pro 240 gat gcc cac got Asp Ala His Ala 787 835 883 ttt got cgc atg Phe Ala Arg Met aag cag aac aag Lys Gin Asn Lys cag Gin 255 gga cct gca gta Gly Pro Ala Val ctt agt Leu Ser 260 aca tta too Thr Leu Ser ott ggt tct Leu Gly Ser 280 cg Pro 265 ctt gtg aag cta Leu Val Lys Leu gaa Glu 270 qcc gag gaa qtc: Ala Glu Glu Val gtc: gaa aag Val Glu Lys 275 aac caa gtc Asn Gin Val gaa gca gta ttt Glu Ala Val Phe gat aco cgo gag Asp Thr Arg Glu cat oto His Leu 295 gga acc gtt gtt Gly Thr Val Val ggg Gi y 300 gca ttg aat att Ala Leu Asn Ile cgc ggc gcc aag Arg Gly Ala Lys gcg Ala 310 too aat ttt gog Ser Asn Phe Ala tgg gtt att gat Trp Val Ile Asp Oct Pro 320 caa aag gat got Gin Lys Asp Ala 1027 1075 1123 gao ott att gtt Asp Leu Ile Val got cog gao gc Ala Pro Asp Ala aco got gog gat Thr Ala Ala Asp ttc ogo Phe Arg 340 gao: got ttg Asp Ala Leu agt ato gat Ser Ile Asp 360 otg Leu 345 cgg gtt ggc atc: Arg Val Gly Ile gao Asp 350 act gtg ogt tat Thr Val Arg Tyr tto aoc aac: Phe Thr Asn 355 too ccc got Ser Pro Ala gga ttg cot ac Gly Leu Pro Thr ttt gtg Phe Val 365 oca gaa oto Pro Glu Leu 1171 1219 1267 gag ota got gag aco aao tat gao gca ctq att gat ato cgt goa aag Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu Ile Asp Ile Arg Ala Lys 375 380 385 tcc gaa ttt gcc gct ggc agc att ccc ggc gcg cag cag ctt tct gga 1315 Ser Giu Phe Ala Ala Giy Ser Ile Pro Giy Ala Gin Gin Leu Ser Gly 390 395 400 405 gqt tcg gcc atg tgq cgc ctc aat gag ctg cct gcg ggt ggc act ttg 1363 Gly Ser Ala Met Trp Arg Leu Asn Giu Leu Pro Ala Gly Gly Thr Leu 410 415 420 gta acc ttc tgc caa tca gga gcg cga aat acc gtg gta gcc aat gct 1411 Val Thr Phe Cys Gin Ser Gly Ala Arg Asn Thr Val Val Ala Asn Ala 425 430 435 ttq cqa cqc gcc gga ttc acc gtt atc gag ctc gag ggc agc tac gcc 1459 Leu Arg Arg Ala Gly Phe Thr Vai Ile Giu Leu Giu Giy Ser Tyr Ala 440 445 450 gcg tgg gaa aaa tca gct gcc aat cct aaa aac ttg cag act gcc gtc 1507 Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn Leu Gin Thr Ala Val 455 460 465 tagttttaga tccggcgctg tat 1530 <210> 132 <211> 469 <212> PRT <213> Corynebacterium glutamicum <400> 132 Met Leu Phe Glu Arg Ile Tyr Glu Giu Gly Leu Ala Gin Ala Ser Tyr 1 5 10 Phe Ile Gly Cys Gin Arg Giu Gly Lys Ala Ile Val Val Asp Ala Arg 25 Arg Asp Ile Gin Thr Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val 40 Ile Ser Ala Vai Thr Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly 55 Thr Arg Glu Leu Ala Ala Ala Thr Gly Ala Glu Ile Phe Leu Ser Gly 70 75 Giu Gly Gly Ala Asp Trp Gin Tyr Gly Phe Thr Gly Thr Thr Leu Met 90 His Asn Ser Thr Ile Lys Leu Gly Asn Ile Thr Ile Thr Ala Lys His 100 105 110 Thr Pro Gly His Thr Pro Giu His Leu Ser Phe Leu Ile Thr Asp Gly 115 120 125 Ala Val Ser Lys Asp Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe 130 135 140 Vai Gly Asp Val Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly 145 150 155 160 Val Asp Thr Arg Phe Ala Gly Ala Gin Gin Leu Phe His Ser Leu Lys 165 170 175 Glu Gly Thr Ser 225 Asp Pro Giu Giu Pro 305 Gin Ala Arg Leu Asp 385 Gin Ala Val1 Giu Gin Al a Val1 210 As p Al a Ala Val1 Gin 290 Arg Lys Al a Tyr Ile 370 Ile Gin Gly Val1 Gly Phe Gly 195 Gly Asp His Val1 Vali 275 As n Gly Asp Asp Phe 355 Ser Arg Leu Gly Ala 435 Ser Al a Pro Glu Al a T yr 245 Se r Lys Val1 Lys Gin 325 Arq As n Al a Lys Gly 405 Le u Al a Ala Leu Cys Lys Gly 230 Phe Thr Le u His Ala 310 Asp Asp Ser Giu Ser 390 Gly Val1 Leu Pro Gly Ala 215 Phe Ala Leu Gly Leu 295 Ser Leu Ala Ile Leu 375 Glu Ser Thr Arg His 185 Ala Ala Glu Met Pro 265 Giu Thr Phe Val1 Leu 345 Gly Giu Al a Met cys 425 Al a Ile Le u Trp Glu Lys 250 Le u Ala Val1 Ala Leu 330 Arg Le u Thr Ala Trp 410 Gin Gly Gin Gly Trp Leu 235 Lys Val1 Val1 Val1 Al a 315 Al a Val1 Pro Asn Gi y 395 Arg Ser Phe Val1 Ala Al a 220 Leu Gin Lys The Gly 300 T rp Pro Gly Thr Tyr 380 Ser Leu Gly Thr Pro 190 Pro T yr Gly Lys Glu 270 Asp be u Ile Ala Asp 350 Val Al a Pro Glu Arg 430 Ile Gly Ser be u Gin Gin 255 Al a Thr Asn Asp As n 335 Thr Pro Leu Gly be u 415 Asn Glu His Thr Arg Pro 240 Gl y Gi u Arg Ile Pro 320 Thr Val1 Glu Ile Ala 400 Pro Thr be u Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn 450 beu 465 Gin Thr Ala Val <210> <211> <2 12> <213> <220> <221> <222> <223> 133 1530 DNA Gorynebacterium giutamicum CoS (101)..(1507) FRXA01833 <400> 133 aaatataccc cccagggtat cttgacagat taaagctcga tgttttaggc tctacatata cccccacggg tatcccctca actttgatct aaggtgtcac atg ctt ttt gaa Met Leu Phe Giu 1 atc tac gaa gaa Ile Tyr Glu Giu ggc Gi y ctc gcc caa gcc agc tat ttc att Leu Ala Gin Ala Ser Tyr Phe Ile 1s cgc qaa ggc Arg Glu Gly tat ctg gac Tyr Leu Asp gcg att gtt gtt Ala Ile Val Val gct cgc ega gat Ala Arg Arg Asp ggc tgc caa Gly Cys Gin atc cag acc Ile Gin Thr gcc gta acc Ala Val Thr 211 259 ctt gca gca aaa Leu Ala Ala Lys aac Asn aac atg gtc att Asn Met Val Ile gaa acc Giu Thr cat att cat gcc His Ile His Ala tat ctc tcc ggt Tyr Leu Ser Gly act Thr cgc gaa ctt gca Arg Glu Leu Ala gct Al a gcc acc qgc gcc Ala Thr Giy Ala gag Glu 75 att ttc ctc tct Ile Phe Leu Ser ggc Gly 80 gaa ggc gga qct Giu Gly Gly Ala ga t Asp tgg caa tat ggc Trp Gin Tyr Gly aca ggc acc acc Thr Giy Thr Thr atg cac aat tcc Met His Asn Ser acc atc Thr Ile 100 aag ctg gaa Lys Leu Giu cca gag cac Pro Giu His 120 atc acc atc aca Ile Thr Ile Thr aag cac act ccc Lys His Thr Pro gga cac act Gly His Thr 115 tca aag gat Ser Lys Asp ctg tca ttt ttg Leu Ser Phe Leu att Ile 125 act gat ggt gcg Thr Asp Gly Ala ccc ggt Pro Gly 135 ttt atg ctc agc Phe Met Leu Ser gac ttc gtc ttc Asp Phe Vai Phe ggt gac gtg gga Gly Asp Val Gly cgt Arg 150 cca gat tta ctt Pro Asp Leu Leu gag gca gct ggc Giu Ala Ala Gly gqc Gly 160 gtg gac acc cgc Val Asp Thr Arg ttc Phe 165 gcc gga gca cag Ala Giy Ala Gin ca a Gin 170 ctc ttc cat agc Leu Phe His Ser cta Le u 175 aaa gag cag ttc Lys Giu Gin Phe ctt gca Leu Ala 180 ctc ccc gao Leu Pro Asp tgt ggc aag Cys Gly Lys 200 cac His 185 att cag gtt tat Ile Gin Val Tyr ggt cat ggt gct Gly His Gly Ala ggc agc oct Gly Ser Pro 195 gga tat gaa Gly Tyr Giu gca ttg ggc gcg Ala Leu Gly Ala ato Ile 205 cot agc acc acc Pro Ser Thr Thr gtg Val1 210 aaq gct Lys Ala 215 aat gcg tgg tgg Asn Ala Trp Trp cca tat ctg cgc Pro Tyr Leu Arg gat gat gaa gcc Asp Asp Giu Ala ttt gtg gaa gag Phe Vai Giu Giu otc gac ggc Leu Asp Gly cag cca Gin Pro 240 gat goc cac gct Asp Ala His Ala 787 835 883 ttt gct ogc atg Phe Ala Arg Met aaa Lys 250 aag cag aac aag Lys Gin Asn Lys gga oct gca gta Gly Pro Ala Val ott agt Leu Ser 260 aca tta tcc Thr Leu Ser ott ggt tct Leu Gly Ser 280 ott gtg aag cta Leu Val Lys Leu gaa Gi u 270 goc gag gaa gto Ala Giu Giu Val gto gaa aag Val Glu Lys 275 aac oaa gto Asn Gin Val 931 979 gaa gca gta ttt Giu Ala Val Phe gat aco ogo gag Asp Thr Arg Giu oaa Gin 290 cat oto His Leu 295 gga aco gtt gtt Gly Thr Val Val goa ttg aat att Ala Leu Asn Ile ogo ggo qoo aag Arg Giy Ala Lys gog Ala 310 too aat ttt gcg Ser Asn Phe Ala tgg gtt att gat Trp Val Ile Asp cct Pro 320 oaa aag gat got Gin Lys Asp Ala 1027 1075 1123 gao ott att gtt Asp Leu Ile Val ttg Leu 330 got cog gao gc Ala Pro Asp Ala aoo got gog gat Thr Ala Ala Asp ttc ogo Phe Arg 340 gao got ttg Asp Ala Leu agt ato gat Ser Ile Asp 360 cgg gtt ggc ato Arg Val Gly Ile act gtg cgt tat Thr Val Arg Tyr tto aoo aao Phe Thr Asn 355 too ooc got Ser Pro Ala 1171 1219 gga ttg cot aco Giy Leu Pro Thr ttt Phe 365 gtg ooa gaa otc Val Pro Giu Leu ato Ile 370 gag ota Giu Leu 375 got gag aoo aao Ala Giu Thr Asn gao gca otg att Asp Ala Leu Ile ato ogt goa aag Ile Arg Ala Lys gaa ttt gcc got Giu Phe Ala Ala ggo ago att coo ggc gog Gly Ser Ile Pro Gly Ala 395 400 cag cag ott tot Gin Gin Leu Ser 1267 1315 1363 1411 ggt tog goc atg Gly Ser Ala Met tgg Trp 410 ogo oto aat gag Arg Leu Asn Giu otg Le u 415 cot gog ggt ggc Pro Ala Gly Gly act ttg Thr Leu 420 gta aco tto tgo caa toa gga gog oga aat aco gtg gta gcc aat got Val Thr Phe Cys Gin Ser Gly Ala Arg Asn Thr Val Val Ala Asn Ala 425 430 435 ttg cga cgc gcc gga ttc acc qtt atc gag ctc gag ggc agc tac gcc 1459 Leu Arg Arg Ala Gly Phe Thr Val Ile Giu Leu Giu Gly Ser Tyr Ala 440 445 450 gcg tgg gaa aaa tca gct gcc aat cct aaa aac ttg cag act qcc gtc 1507 Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn Leu Gin Thr Ala Val 455 460 465 tagttttaga tccggcgctg tat 1530 <210> 134 <211> 469 <212> PRT <213> Corynebacterium glutamicum <400> 134 Met Leu Phe Glu Arg Ile Tyr Glu Giu Gly Leu Ala Gin Ala Ser Tyr 1 5 10 Phe Ile Gly Cys Gin Arg Giu Gly Lys Ala Ile Val Val Asp Ala Arg 25 Arg Asp Ile Gin Thr Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val 40 Ile Ser Ala Val Thr Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly 55 Thr Arg Giu Leu Ala Ala Ala Thr Gly Ala Giu Ile Phe Leu Ser Gly 70 75 Giu Gly Gly Ala Asp Trp Gin Tyr Gly Phe Thr Gly Thr Thr Leu Met 90 His Asn Ser Thr Ile Lys Leu Glu Asn Ile Thr Ile Thr Ala Lys His 100 105 110 Thr Pro Gly His Thr Pro Giu His Leu Ser Phe Leu Ile Thr Asp Gly 115 120 125 Ala Val Ser Lys Asp Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe 130 135 140 Vai Gly Asp Val Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly 145 150 155 160 Val Asp Thr Arg Phe Ala Gly Ala Gin Gin Leu Phe His Ser Leu Lys .165 170 175 Giu Gin Phe Leu Ala Leu Pro Asp His Ile Gin Val Tyr Pro Gly His 180 185 190 Gly Ala Gly Ser Pro Cys Gly Lys Ala Leu Gly Ala Ile Pro Ser Thr 195 200 205 Thr Val Gly Tyr Glu Lys Ala Asn Ala Trp Trp Ala Pro Tyr Leu Arg 210 215 220 Ser Asp Asp Glu Ala 225 Phe Val Glu Glu Leu Leu Asp Gly Gin Pro Asp Ala Pro Ala Glu Val Glu Gin 290 Pro Arg 305 Gin Lys Ala Ala Arg Tyr Leu Ile 370 Asp Ile 385 Gin Gln Ala Gly Val Val Glu Gly 450 Leu Gin 465 <210> I' His Ala Tyr 245 Val Leu Ser 260 Val Giu Lys 275 Asn Gin Val Gly Ala Lys Asp Ala Gin 325 Asp Phe Arg 340 Phe Thr Asn 355 Ser Pro Ala Arg Ala Lys Leu Ser Gly 405 Gly Thr Leu 420 Ala Asn Ala 435 Ser Tyr Ala Thr Ala Val Phe Thr Le u His Ala 310 Asp Asp Ser Glu Ser 390 Gly Val1 Leu Al a Arg Ser Ser 280 Gly Asn Ile Le u Asp 360 Al a Phe Ala Phe Arg 44D Met Pro 265 Giu Thr Phe Val1 Le u 345 Gly Glu Al a Met Cys 425 Ala Gin Lys Phe Gi y 300 Trp Pro Gly Thr Tyr 380 Ser Le u Gi y Thr Ala 460 As n Leu Val1 285 Al a Val1 Asp Ile Ph e 365 Asp Ile As n Al a Val1 445 Lys Giu 270 Asp Le u Ile Ala Asp 350 Val1 Ala Pro Giu Arg 430 Ile Glu Lys Ser Ala Asn Pro Lys Asn <211> 675 <212> DNA <213> <220> <221> <222> <223> <400> Corynebacterium glutamicum CDS (652) RXA01853 135 gaatgtccaa cgtcaaaaaa attcttttct atcctaaccg tatcttcaca ccttgaggga atgatqqggg agcgccgctt acgcactaca ctgtttattc atg Met 1 gag atc ctc Glu Ile Leu gga Gly ttc gcg gct ggt Phe Ala Ala Gly tat aaa aca aat Tyr Lys Thr Asn tgc Cys tat gtg gtg cgc Tyr Val Val. Arg ggg gag Gly Glu aat gag gtc Asn Glu Val. gtg gaa tac Val. Glu Tyr gcg Ala atc att gat cct Ile Ile Asp Pro atg cat gcc cac Met His Ala His gat gat ttg Asp Asp Leu att gtg ctc Ile Val Leu atc acc acg aat Ile Thr Thr Asri ttg agc gtg gac Leu Ser Val Asp aag Lys acc cac Thr His gga cac att gat Gly His Ile Asp cac His acc cgt gat gct Thr Arg Asp Ala gtt gtg gca aag Val. Val Ala Lys ttc aat gcg ccg Phe Asn Ala Pro tat atc cat cct Tyr Ile His Pro gat gcg ttt ttc Asp Ala Phe Phe ctt Le u gag qtc tac aag Glu Val Tyr Lys tct gga aca aaq Ser Gly Thr Lys a cg Thr gcc atg ctt ttc Ala Met Leu Phe gac gcc Asp Ala 100 gac aac atg Asp Asn Met ggt gag aca Gly Glu Thr 120 gt g Val1 105 tcc cct gat cct Ser Pro Asp Pro tca ctg cgt gat Ser Leu Arg Asp ctg qtt gat Leu Val Asp 115 aag cat gca Lys His Ala atc act ttg gct Ile Thr Leu Ala gaa gaa ttc acg Glu Giu Phe Thr ttg Le u 130 cca ggg Pro Giy 135 cat tca cct ggt His Ser Pro Gly tgt Cys 140 acg ctg atc gtc Thr Leu Ile Val gg c Gly 145 aag gaa tac tgc Lys Glu Tyr Cys agc ggt gat gtg Ser Gly Asp Val. t tq Leu 155 ttc aag qqc tct Phe Lys Gly Ser ggt cgc act gat Gly Arg Thr Asp ttt Phe 165 gag tgg tct gat Glu Trp, Ser Asp gat qcc atg aat Asp Ala Met Asn gag Giu 175 tca cta cgc acg Ser Leu Arg Thr gca gtg Ala Val. 180 ctc cca ctt Leu Pro Leu tgatgatgca ttgcagattc ttc <210> 136 <211> 184 <212> PRT <213> Corynebacterium giutamicum <400> 136 Met Val Ala Asp Gi y Asp Met Arg Thr Gly 145 Gly Leu Glu Ile Leu Gly Phe Ala Ala Gly Pro Tyr Lys Thr Asn 10 Cys Tyr Val1 His Lys Val Ala Le u Asp Leu 130 Lys Arg Arg Gly Asp Val1 Ala Phe Asp 100 Val1 His Tyr Asp Al a 180 Glu Leu Leu Lys Le u Al a Asp Al a Cys Phe 165 Val1 As n Val1 Thr Arg 70 Glu Asp Gly Pro Phe 150 Glu Leu Val1 Tyr Gly As n Tyr Met Thr 120 His Gly Se r Leu Ile Thr Asp Val1 75 Ser Pro Leu Gly Leu 155 Asp Asp As n His Tyr Gly Asp Al a Cys 140 Phe Al a Pro Asn Thr I le Thr Pro Gly 125 T hr Lys Met Gly Leu Arg His Lys Glu 110 Glu Leu Gly Asn Met Ser Asp Pro Thr Ser Glu Ile Ser Glu 175 His Val1 Al a Asp Al a Leu Phe Val1 I le 160 Ser <210> 137 <211> 723 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(700) <223> RXN02424 <400> 137 agccaatqct caactgccct tcaaaatcga tttttqtcgc ttcaaaaaat acaccttcga acatagcatc gaacaaggtg tttccgctaq tctgaaccac atg act aac gag ctc Met Thr Asn Glu Leu 1 act ctt cac cat att tcc gtg tcc caa atg qac aac aat tgc tac ctt Thr Leu His His Ile Ser Val Ser Gln Met Asp Asri Asn Gys Tyr Leu 15 ttq gcc gca aat ggc aac gqt tta ctc att gat got gca gat gac gca Leu Ala Ala Asn Gly Asn Gly Leu Leu Ile Asp Ala Ala Asp Asp Ala 30 gct gca cta Ala Ala Leu ctt aaa tta gcc Leu Lys Leu Ala gat gcc ggt gtg Asp Ala Gly Val acc atc acc aaa Thr Ile Thr Lys gca ttg ccg gag Ala Leu Pro Giu gtg ttg Val Leu acc acc cac cgc. Thr Thr His Arg gca gac cac gtc Ala Asp His Val ctc cag aag acc Leu Gin Lys Thr gga gca act cac tac gcg Gly Ala Thr His Tyr Ala cct ttc ctt gag Pro Phe Leu Glu cca gct ttg ccc Pro Ala Leu Pro gct gtt gat gtg Ala Val Asp Val gaa Glu ctg cat cat ggt Leu His His Gly gat tca, Asp Ser 100 att gaa ttt Ile Glu Phe acc cca ggc Thr Pro Gly 120 gag Giu 105 ggt cat gta ttc Gly His Val Phe atc agc att ctg Ile Ser Ile Leu cgc ggc cac Arg Giy His 115 aaa act cac Lys Thr His ggt gca gta ctc Gly Ala Val Leu gct gag atc gac Ala Giu Ile Asp ctt ttc Leu Phe 135 gtg ggt gac agc Val Gly Asp Ser ctc Leu 140 ttc ccc ggc ggt Phe Pro Gly Gly ttg Leu 145 ggc aaa acc agc Gly Lys Thr Ser agc Ser 150 gaa ggc gac ttc Giu Gly Asp Phe cga ctg ttc aac Arg Leu Phe Asn gtc aaa gag cgc Val Lys Glu Arg 547 595 643 ttt gac acc tac Phe Asp Thr Tyr gat gac agc atc Asp Asp Ser Ile gtg Val 175 tgg cca ggt cac Trp Pro Gly His ggc aag Gly Lys 180 gaa acc acc Giu Thr Thr cgt cgc tgg Arg Arg Trp 200 ctt Le u 185 gga gcc gag cgt Gly Ala Glu Arg cag ctg gaa atc Gin Leu Glu Ile tgg tgg gag Trp Trp Glu 195 taagcgcttt tctcaaccag gca <210> 138 <211> 200 <212>' PRT <213> Corynebacterium giutamicum <400> 138 Met Thr Asn Giu Leu Thr Leu His His 1 5 Asn Asn Cys Tyr Leu Leu Ala Ala Asn 25 Ala Ala Asp Asp Ala Ala Ala Leu Leu Ile 10 Ser Val Ser Gin Met Asp Giy Asn Gly Leu Leu Ile Asp Asp Ala Gly Lys Leu Ala Val Thr Ile Thr Lys Val Leu Thr Thr His Arg His Ala Asp His Val* 55 Arg Ala Leu Pro Giu Val Leu Gin Lys Thir Giy Ala Thr His Tyr Ala 70 75 Pro Phe Leu Giu Vai Pro Ala Leu Pro Ser Ala Val Asp Val Giu Leu 90 His His Gly Asp Ser Ile Giu Phe Glu Gly His Val Phe Pro Ile Ser 100 105 110 Ile Leu Arg Gly His Thr Pro Gly Gly Ala Val Leu Thir Ala Glu Ile 115 120 125 Asp Gly Lys Thr His Leu Phe Val Gly Asp Ser Leu Phe Pro Gly Gly 130 135 140 Leu Gly Lys Thr Ser Ser Giu Gly Asp Phe Val Arq Leu Phe Asn Asp 145 150 155 160 Val Lys Giu Arg Ile Phe Asp Thr Tyr Asp Asp Asp Ser Ile Val Trp 165 170 175 Pro Giy His Gly Lys Glu Thr Thir Leu Gly Ala Giu Arg Pro Gin Leu 180 185 190 Glu Ile Trp Trp Glu Arg Arg Trp 195 200 <210> 139 <211> 404 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> <223> FRXA02424 <400> 139 acc gga gca act cac tac gcg cct ttc ctt gag gtg cca gct ttg ccc 48 Thr Gly Ala Thir His Tyr Ala Pro Phe Leu Glu Vai Pro Ala Leu Pro 1 5 10 tcc gct gtt gat gtg gaa ctg cat cat ggt qat tca att gaa ttt gag 96 Ser Ala Val Asp Val Glu Leu His His Gly Asp Ser Ile Giu Phe Giu 25 ggt cat gta ttc cct atc agc att ctg cgc ggc cac acc cca ggc ggt 144 Gly His Val Phe Pro Ile Ser Ile Leu Arg Giy His Thr Pro Gly Gly 40 gca gta ctc acc get gag ate gac ggt aaa act cac ctt ttc gtg ggt 192 Ala Val Leu Thr Ala Giu Ile Asp Gly Lys Thr His Leu Phe Val Gly 55 gac agc ctc ttc ccc ggc ggt ttg ggc aaa ace agc agc gaa ggc gac 240 Asp Ser Leu Phe Pro Gly Gly Leu Gly Lys Thr Ser Ser Glu Gly Asp 70 75 tic gtc cga ctg ttc aac gat gtc aaa gag cgc atc itt qac acC tac 288 Phe Val Arg Len Phe Asn Asp Val Lys Gin Arg Ile Phe Asp Thr Tyr 90 9 gac gat gac agc atc gig tgg cca qqt cac ggc aag gaa acc acc cti 336 Asp Asp Asp Ser Ile Val Trp Pro Gly His Gly Lys Gin Thr Thr Leu 100 105 110 gga gcc gag cgt cca cag cig gaa atc tqg igg gag cgi cgc igg 381 Gly Ala Gin Arg Pro Gin Len Giu Ile Trp Trp Glu Arg Arg Trp 115 120 125 taagcgciii icicaaccag gca 404 <210> 140 <211> 127 <212> PRT <213> Corynebacterium giniamicum <400> 140 Thr Gly Aia Thr His Tyr Ala Pro Phe Len Gin Val Pro Ala Leu Pro 1 5 10 Ser Aia Val Asp Val Glu Len His His Gly Asp Ser Ile Giu Phe Giu 25 Gly His Val Phe Pro Ile Ser Ile Leu Arg Gly His Thr Pro Gly Gly 40 Ala Vai Leu Thr Ala Giu Ile Asp Gly Lys Thr His Len Phe Val Gly 55 Asp Ser Len Phe Pro Gly Gly Leu Gly Lys Thr Ser Ser Giu Gly Asp 70 75 Phe Val Arg Leu Phe Asn Asp Val Lys Gin Arg Ile Phe Asp Thr Tyr 90 Asp Asp Asp Ser Ile Val Trp Pro Gly His Gly Lys Giu Thr Thr Len 100 105 110 Gly Ala Gin Arg Pro Gin Leu Giu Ile Trp Trp Gin Arg Arg Trp 115 120 125 <210> 141 <211> 882 (212> DNA <213> Corynebacterium gintamicum <2 <221> CDS <222> (101)..(859) <223> RXN00419 <400> 141 gctggttgaa gacicgaaai gagatcgacc caaccggagt ctttgcatct gacaigtccc gccgactqa gctiicttaa qaaagggcti gaactaaaca atg ctt aac qca gtg 115 Met Leu Asn Ala Val 1 gga acc tot gag Gly Thr Ser Giu gge aaa gcCc aa Gly Lys Ala Gin aac As n att ctc ott ctt Ile Leu Leu Leu ggt Gly 15 atc ggt Ile Gly att toc att Ile Ser Ile ttg gca gog Leu Ala Ala tee cgc ttc etc Ser Arg Phe Leu aag Lys cag ggt cca tcc Gin Gly Pro Ser cat gtg acc His Val Thr gtc gca gag Val Ala Glu cgt aaa gat tcc Arq Lys Asp Ser cgc gtg gac gca Arg Val Asp Ala atc aaa Ile Lys gca gct ggc gct Ala Ala Gly Ala tcc gtt gct gtt Ser Val Ala Val gt t Val1 gat ttc gat gcg Asp Phe Asp Ala etc Leu gac ace gaa toe Asp Thr Glu Ser eac His 75 ect gca gee ate Pro Ala Ala Ile gac Asp gea gee ttt gaa Ala Ala Phe Giu ggc gac gtt gae Gly Asp Val Asp gea ate gtg get Ala Ile Val Ala ggo ate etc ggc Gly Ile Leu Gly gac aac Asp Asn 100 gaa gca eag Glu Ala Gln aac tac ace Asn Tyr Thr 120 ege gac caa gca Arg Asp Gln Ala eta Leu 110 gea gtg gaa goa Ala Val Glu Ala aec ace gtg Thr Thr Val 115 cag aaa ttt Gln Lys Phe gee gge gtt tee Ala Gly Val Ser ggt gta ctg etg Gly Val Leu Leu gag cag Giu Gin 135 cag ggc cac gge Gin Gly His Gly ate gtg gea ttg Ile Val Ala Leu tot gtg gca ge Ser Val Ala Gly cag Gin 150 oga gte ego ego Arg Val Arg Arg tee Ser 155 aae ttt gte tao Asn Phe Val Tyr gge Gly 160 tee gee aag goa Ser Ala Lys Ala ggt Gi y 165 ttc gao ggt ttc Phe Asp Gly Phe ace eag cto ggc Thr Gln Leu Gly gee ctg cgt gga Ala Leu Arg Gly tee ggt Ser Gly 180 gee aae gta Ala Asn Val gca gat ggt Ala Asp Gly 200 gtg gtt ego eca Val Vai Arg Pro gge Gly 190 eag gta ego ac Gln Val Arg Thr aag atg toe Lys Met Ser 195 gao gtg gea Asp Val Ala ggc gaa gee eca Gly Glu Ala Pro ace gte aao ego Thr Val Asn Arg gat get Asp Ala 215 gtt tat gat gea Val Tyr Asp Ala gtg Val1 220 gtg aae aag aag Val Asn Lys Lys gac Asp. 225 ate ate ttt gte Ile Ile Phe Val cac cca otg tte cag tae gte tct ttt gog tte caa ttc att cog ega His Pro Leu Phe Gin Tyr Val. Ser Phe Ala Phe Gin Phe Ile Pro Arg 230 235 240 245 gca atc ttc cgc aag ctq ccg ttc taacggaagt tacggaagtt acq 882 Ala Ile Phe Arg Lys Leu Pro Phe 250 <210> 142 (211> 253 <212> PRT <213> Corynebacterium glutamicum (400> 142 Met Leu Asn Ala Val Gly Lys Ala Gin Asn Ile Leu Leu Leu Gly Gly 1 5 10 Thr Ser Glu Ile Gly Ile Ser Ile Val Ser Arg Phe Leu Lys Gin Gly 25 Pro Ser His Val Thr Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp 40 Ala Ala Val Ala Glu Ile Lys Ala Ala Gly Ala Ala Ser Vai Ala Val 55 Val Asp Phe Asp Ala Leu Asp Thr Glu Ser His Pro Ala Ala Ile Asp 70 75 Ala Ala Phe Giu Asn Gly Asp Val Asp Val Ala Ile Val Ala Phe Giy 90 Ile Leu Gly Asp Asn Glu Ala Gin Trp Arg Asp Gin Ala Leii Ala Val 100 105 110 Giu Ala Thr Thr Val Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu 115 120 125 Leu Gly GIn Lys Phe Giu Gin Gin Gly His Gly Thr Ile Val Ala Leu 130 135 140 Ser Ser Val Ala Giy Gin Arg Val Arg Arg Ser Asn Phe Val Tyr Gly 145 150 155 160 Ser Ala Lys Ala Gly Phe Asp Gly Phe Tyr Thr Gin Leu Gly Giu Ala 165 130 175 Leu Arg Gly Ser Gly Ala Asn Val Leu Val Val Arg Pro Gly Gin Val 180 185 190 Arg Thr Lys Met Ser Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn 195 200 205 Arg Glu Asp Val Ala Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys 210 215 220 Asp Ilie Ile Phe Val His Pro Leu Phe Gin Tyr Val Ser Phe Ala Phe 225 230 235 240 Gin Phe Ile Pro Arg Ala Ile Phe Arg Lys Leu Pro Phe 245 250 <210> <211> <212> <213> <220> <221> <222> <223> 143 485 DNA Corynebacterium giutamicum CDS FRXA004 19 <400> 143 gac aac gaa gca cag Asp Asn Glu Ala Gin 1 5 tgg cgc gac caa Trp Arg Asp Gin cta gca gtg gaa Leu Ala Val Giu gca acc Ala Thr acc gtg aac Thr Val Asn aaa ttt gag Lys Phe Glu acc gcc ggc gtt Thr Ala Gly Val gta ggt gta ctg Val Gly Val Leu ctg ggc cag Leu Gly Gin tcc tct gtg Ser Ser Val cag cag ggc cac Gin Gin Gly His acc atc gtg gca Thr Ile Val Ala ttg Leu gca ggc Ala Gly cag cga gtc cgc Gin Arg Val Arg cgc Arg tcc aac ttt gtc Ser Asn Phe Val ggc tcc qcc aag Gly Ser Ala Lys ggt ttc gac qgt Gly Phe Asp Gly tac acc cag ctc Tyr Thr Gin Leu ggc Gly gaa gcc ctg cgt Glu Ala Leu Arg gga Gl y tcc ggt gcc aac Ser Gly Ala Asn gta Val1 ttg gtg gtt cgc Leu Val Vai Arg eca Pro 90 ggc cag gta cgc Gly Gin Val Arg acc aag Thr Lys atg toc gca Met Ser Ala gtg gca gat Val Ala Asp 115 ggt ggc gaa gcc Gly Gly Glu Ala ctq acc qtc aac Leu Thr Val Asn cgc gaa gac Arg Glu Asp 110 gac atc atc Asp Ile Ile gct qtt tat gat Ala Val Tyr Asp gtg gtg aac aag Val Val Asn Lys aag Lys 125 ttt gtc Phe Val 130 cac cca ctg, ttc His Pro Leu Phe cag Gin 135 tac gtc tct ttt Tyr Val Ser Phe ttc caa ttc att. Phe Gin Phe Ile cga gca atc ttc Arg Ala Ile Phe aag ctg ccg ttc Lys Leu Pro Phe taacggaaqt tacggaagtt 485 <210> <211> (212> <213> 144 154 P RT Corynebacterium glutainicum <400> 144 Asp 1 Thr Lys Ala Ala Se r Met Val1 Phe Pro 145 As n Val1 Phe Gly Gly Gly Ser Ala Val 130 Arg Glu As n Glu Gin Phe Al a Al a Asp 115 His Al a Gin 5 Thr Gin Val1 Gly Val1 Gly Val1 Le u Phe Trp Al a Gly Arg Phe 70 Leu Gly T yr Phe Arg 150 Arg Gly His Arg T yr Val Glu Asp Gin 135 Lys Asp Val1 Gly 40 Se r Thr Val1 Ala Ala 120 Tyr Leu Gin Ser Thr Asn Gin Arg Pro 105 Val Val Pro Al a 10 Val1 Ile Phe Leu Pro 90 Leu Val1 Ser Phe Val1 Le u Leu Gly Ala Val1 Asn Lys 125 Phe Glu Leu Ser Ser Le u Arg Arq 110 Asp Gin Ala Gly Ser Ala Arg Thr Glu Ile Phe Th r Gin Val1 Lys Gly Lys Asp Ile Ile <210> 145 <211> 259 <212> DNA <213> Corynebacterium giutamioun <220> <221> CDS <222> (259) <223> FRXA00421 <400> 145 gctggttgaa gactcgaaat qagatcgaoc caacoggagt gocgaottga gotttcttaa gaaagggctt gaactaaaca ggc aaa Gly Lys att tc Ile Ser ttg gca Leu Ala aac Asn too Ser aaa Lys oto Leu ttc Phe too Ser ct t Le u aag Lys cgo Arg ctttgcatct gaoatgtocc atg ctt aac gca gtg Met Leu Asn Ala Vai 1 acc tct gag atc ggt Thr Ser Giu Ile Gly cca tcc cat gtg aco Pro Ser His Val Thr gca qoa gtc gca gag Ala Ala Val Ala Giu <210> 146 <211> 53 <212> PRT <213> Corynebacterium giutamioum <400> 146 Met Leu Asn Ala Val Gly Lys Ala Gin Asn Ile Leu Leu Leu Gly Gly 1 5 10 Thr Ser Glu Ile Gly Ile Ser Ile Val Ser Arg Phe Leu Lys Gin Giy 25 Pro Ser His Val Thr Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp 40 Ala Ala Val Ala Glu <210> 147 <211> 861 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (838) <223> RXN02923 <400> 147 gcatotaoat tgaaggaato cacggagcgc gcatogaaga catcgttgtg gtgaatgaag acggttgtga aaccctoaac aaooagoooa aggaactgcg ttg agc att ctt ctc Ill Leu Ser Ile Leu Leu ct a Leu cac His 9gc Giy t tg Leu aaa Lys ggc Gly gta gqc Gly ggc Gly tta Le u agc Se r aca Thr atc Ile gja g ac Tb r gao Asp gaa Giu gac Asp gag Gi u gga Gi y 900 gao Asp gtt Val1 ctt Le u caa Gin gc t Ala 75 caa Gin gt g att Ile ttg Leu cga Ar g gta Val1 60 ggo Gly gaa Giu gat ggt gag Gly Glu got oqt Aia Arq 30 ogc gqt Arg Gly gao acg Asp Thr att too Ile Ser gca qaa Ala Giu aoo got 1 att goo Ile Ala oga ooa Arg Pro qoo aoa Ala Thr oao oga His Arg ott gc Leu Ala aoo gat Thr Asp oag gtc ttg Le u got Al a gt t Val1 ott Le u gtL Val1 acc Thr atg Val gtg Val1 gcg Al a tat T yr 150 gat Asp ttt Ph e gtg Val1 aag Lys 9CC Ile gct Ala 120 t cc Ser tcc Ser ctg Leu att Ile cca Pro 200 a gg Arg att Th r gag Glu att Ile aa g Lys 999 Gly 170 t ct Ser gat Asp a cg Thr C99 Val1 ctc Leu gct Ala gct Al a 155 a ca Thr atg Met gt t Val1 acc Thr atg Met 235 Tyr Thr Ala Gin 110 gca caa act act Ala Gin Thr Thr 125 tgg cgg gcg cgc Trp Arg Ala Arg ctc gat gca ttt Leu Asp Ala Phe 160 gtg cqa ttg att Val Arg Leu Ile 175 acg gqg atg aag Thr Giy Met Lys 190 gca gct gtt gtt Ala Ala Val Val 205 tgg att ccg qga Trp Ile Pro Gly Cet Cgt ceg gtg Pro Arg Pro Val 240 Met 115 gcg Aia aac As n ggg Giy 09 t Arg ccg Pro 195 tat T yr cgq Arg 499 547 595 643 691 739 787 835 Aia Trp Ile Met Arg 230 tgg egg aag atg cca Trp Arg Lys Met Pro 245 cgc Arg tagatacccg ttcagccctc aca <210> 148 <211> 246 <212> PRT <213> Corynebacterium giutamicum <400> 148 Leu Ser Ile Leu Leu Leu Giy Gly Thr Ser Asp 1 5 10 Ala Thr Leu Thr Cys His Gly Glu Asp Val Val 25 Pro Giu Aia Ala Gin Gly Leu Ala Glu Asp Leu 40 Thr Ser Val His Val Leu Ser Phe Asp Ala Gin 55 Arg Glu Leu Val Lys Lys Thr Gin Giu Leu Aia 70 Ile Ala Giy Glu Leu Ala Aia Arg Arg Gin Arg Gly Val Leu Asp Thr Gly Giu Ile Ser Ala Val Val Ala Phe Gly Ile Leu Gly Asp Gin Glu Arg Ala 90 Glu Thr Gi u Ser Al a 130 Pro Gin Ala Al a Ala 210 Leu Arg Val1 Val1 Al a Tyr 150 Asp Phe Val1 Lys Ala 230 Ile Ala 120 Se r Ser Leu Ile Pro 200 Arg Ile Al a 105 Asp Ser Thr His Gi y 185 Arg Ser Met Asp Arg Gly 140 Gly His Thr Al a Leu 220 Val1 Gin Thr Arg Phe 160 Ile Lys Val1 Gly Val1 240 Met Pro Arg 245 <210> 149 <211> 1203 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> 101)..(1180) <223> RXN02922 <400> 149 cccaccgcgg cgcaagctac cgcctaggcg ctcggaactc gttccatatc cgcccaacta gtttcccagg gagcccactc aca atc atc qac aat ott got cca gto cto gcq Thr Ile Ile Asp Asn Leu Ala Pro Val Leu Ala 15 got qcg cag cgo gaa cag gat cga gaa ttc agc Aia Ala Gin Arg Giu Gin Asp Arg Glu Phe Ser 30 cag ctt agt gcc ggt ggg ttc act aaa ctc cgc Gin Leu Ser Ala Gly Gly Phe Thr Lys Leu Arq oaoogooact attgatotca atg atc tca cog caa 115 Met Ile Ser Pro Gin 1 gag ato goa goa acg 163 Glu Ile Ala Ala Thr cgt gat ttg gca aag 211 Arq Asp Leu Ala Lys att coa gtt gaa ttt 259 Ile Pro Val Glu Phe ggc ggt Gly Gly ttg ggt ttt agc Leu Gly Phe Ser eca gaa gca ttt Pro Glu Ala Phe gtg ctg gtg gca Val Leu Val Ala geg Al a 9CC gct gca gat Ala Ala Ala Asp aat ate geg cag Asn Ile Ala Gln gga Gi y ttg egg cct eac Leu Arg Pro His 307 355 403 ttg gca gtg gag Leu Ala Val Glu agc Ser tta ttg atc gct Leu Leu Ile Ala tat tca gag cac Tyr Ser Glu His cgc ac Arg Thr 100 aag tgg ctg Lys Trp Leu ttg act gaa Leu Thr Glu 120 aaa atc get gag Lys Ile Ala Giu gge gtg gtc att Gly Val Val Ile ggc aat gcg Gly Asn Ala 115 aag atc cga Lys Ile Arg 451 499 gtg gga aac aag Val Gly Asn Lys eca Pro 125 ggt gag ctg aaa Gly Glu Leu Lys aag gaa Lys Glu 135 ggc gag tet tac Gly Glu Ser Tyr etc age gac acc Leu Ser Asp Thr tte tat tee aeg Phe Tyr Ser Thr ggc Gly 150 aqt ctt tac gcc Ser Leu Tyr Ala tgg att eaa gta Trp Ile Gin Val eat His 160 geg aaa gat gag Ala Lys Asp Giu 547 595 643 gat caa gat gtt Asp Gin Asp Val gee ttt gtt gat Ala Phe Val Asp gac gca tea gge Asp Ala Ser Gly gtt gtt Val Val 180 ttg gtg gat Leu Val Asp acc agc te Thr Ser Phe 200 tac Tyr 185 tgg gac gaa ttt Trp Asp Glu Phe eaa eaa eta ttt Gin Gin Leu Phe gee tee gga Ala Ser Gly 195 att gte ace Ile Val Thr ttt gaa aaa gte Phe Glu Lys Val gta gat eca etg Val Asp Pro Leu ga e Asp 210 cgt gat Arg Asp 215 tac ace gea c Tyr Thr Ala Pro age Se r 220 get ttc eag geg Ala Phe Gin Ala geg eag tea cat Ala Gin Ser His ttg tet aeg ttg Leu Ser Thr Leu ggt att teg eag Gly Ile Ser Gin gea Al a 240 ate ace egt gae Ile Thr Arg Asp gtt ace tat gta Val Thr Tyr Val caa Gin 250 aac ege ace egt Asn Arg Thr Arg tte age eac gga Phe Ser His Gly agt ggt Ser Gly 260 gac ctt eca Asp Leu Pro aaa gee aag Lys Ala Lys 280 ege Arg 265 ttt gat ceg eag Phe Asp Pro Gin eaa eag gtg gtg Gin Gin Val Val ggt gag gtg Gly Glu Val 275 tte gca eaa Phe Ala Gin teg tat gea gte Ser Tyr Ala Val aaa ate ttt cag Lys Ile Phe Gin gaa ctg gat ett gtc gte gat aag gca aaa gcc ggc act get acg gag 1027 Glu Leu Asp Leu Val Val Asp Lys Ala Lys Ala Gly Thr Ala Thr Glu 295 300 305 gtc gat ctg gcc gct gte gac ctg agc gcc tac caa gcc cag tta gcg 1075 Val Asp Leu Ala Ala Val Asp Leu Ser Ala Tyr Gin Ala Gin Leu Ala 310 315 320 325 gtg gca cot ttg gtg ctg age cag gcc acc cag gcc ttt gag gtt gge 1123 Val Ala Pro Leu Val Leu Ser Gln Ala Thr Gin Ala Phe Glu Val Gly 330 335 340 gca gat gcc tta aac gqc ggc cac qtq get gcc caa tao acg ate gga 1171 Ala Asp Ala Leu Asn Gly Gly His Val Ala Ala Gln Tyr Thr Ile Gly 345 350 355 tee ttg tea tgageeaaga aattttgage cat 1203 Ser Leu Ser 360 <210> 150 <211> 360 <212> PRT <213> Corynebacterium giutamicum <400> 150 Met Ile Ser Pro Gin Thr Ile Ile Asp Asn Leu Ala Pro Val Leu Ala 1 5 10 Giu Ile Ala Ala Thr Ala Ala Gin Arg Giu Gln Asp Arg Giu Phe Ser 25 Arg Asp Leu Ala Lys Gin Leu Ser Ala Gly Gly Phe Thr Lys Leu Arg 40 Ile Pro Val Giu Phe Gly Gly Leu Gly Phe Ser Leu Pro Glu Ala Phe 55 Giu Val Leu Val Ala Ala Ala Ala Ala Asp Ser Asn Ile Ala Gin Gly 70 75 Leu Arg Pro His Phe Leu Ala Val Glu Ser Leu Leu Ile Ala Pro Tyr 90 Ser Giu His Arg Thr Lys Trp Leu Arg Lys Ile Ala Giu Lys Gly Val 100 105 110 Val Ile Gly Asn Ala Leu Thr Giu Val Gly Asn Lys Pro'Gly Glu Leu 115 120 125 Lys Thr Lys Ile Arg Lys Giu Gly Glu Ser Tyr Val Leu Ser Asp Thr 130 135 140 Lys Phe Tyr Ser Thr Gly Ser Leu Tyr Ala Asp Trp Ile Gin Val His 145 150 155 160 Ala Lys Asp Glu Glu Asp Gin Asp Val Phe Ala Phe Val Asp Arg Asp 165 170 175 Ala Ser Gly Val Val Leu Val Asp 180 Leu Le u Leu 225 Ile Ser Val1 Gin Gly 305 Gin Al a Gin Phe Asp 210 Ala Thr His Vai GI y 290 Thr Al a Phe Tyr Ala 195 Ile Gin Arg Gly Gi y 275 Phe Ala Gin Glu Thr 355 Ser Val1 Ser Asp Ser 260 Giu Ala Thr Leu Val1 340 Ile Gly Thr His Ile 245 Gly ValI Gin Giu Ala 325 Gly Gly Ser Asp 215 Le u Thr Leu Ala Le u 295 Asp Ala Asp Leu Ph e 200 Tyr Ser Tyr Pro Lys 280 Asp Leu Pro Al a Se r 360 Tyr 185 Phe Th r Th r Val1 Arg 265 Ser Leu Al a Leu Leu 345 Trp Asp Giu Phe Gly Gin Gin 190 Glu Ala Leu Gin 250 Phe Tyr Val1 Ala Val1 330 As n Val1 205 Al a Ile Thr Gin Giu 285 Lys Le u Gin His Val1 Phe Ser Arg Val1 270 Lys Al a Se r Al a Val1 350 Pro Al a Ala 240 Phe Gin Phe Ala Tyr 320 Gin Al a <210> 151 <211> 516 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(493) <223> RXN03065 <400> 151 gacggcgcca actctgcatt cttcgcctca gcgtgcgtgg cagtgtttgc actgatcqtg ggcttctttg taaagaggcc agcccgctaa gctaggtcgc atg atc agc att gga 115 Met Ile Ser Ile Gly 1 aec gac ctc gtt cac att tcg gcg ttc qca qag cag ctt gca cag ccg 163 Thr Asp Leu Val His Ile Ser Ala Phe Ala Glu Gin Leu Ala Gin Pro 15 gga agt tcc ttc atg gag gtg tit tcc gca ggg gag cgt cgt aaa gca 211 Gly Ser Ser Phe Met Giu Val Phe Ser Ala Gly Glu Arg Arg Lys Ala 30 aat gaa cgc cag gca agc cgc tac gcc gag cat ttg gcg ggg cgg tgg 259 Asn Glu Arg Gin Ala Ser Arg Tyr Ala Glu His Leu Ala Gly Arg Trp 45 gcg gca aaa gaa tcc ttt att aag gcc tqg tca cag gcc att tat 99C 307 Ala Ala Lys Glu Ser Phe Ile Lys Ala Trp Ser Gin Ala Ile Tyr Gly 60 cag cca ccc gtg atc gcc gaa gaa gcc gtg gtg tgg cgg gac atc gaa 355 Gin Pro Pro Val Ile Ala Glu Glu Ala Val Val Trp Arg Asp Ile Glu 75 80 gtt cgc gca gac: gcg tgg ggg cgc gtc gcg atc gaa ttg gcg ccc gaa 403 Val Arg Ala Asp Ala Trp Gly Arg Val Ala Ile Glu Leu Ala Pro Glu 95 100 ttg gcc gca gtg gtc cgg gaa tcc: atc ggg gag ttt tcc agc agc ttg 451 Leu Ala Ala Val Val Arg Giu Ser Ile Gly Giu Phe Ser Ser Ser Leu 105 110 115 agc atc agc cac gac ggc gac tac gcg qtg qaa cgt gcg tgt 493 Ser Ile Ser His Asp Gly Asp Tyr Ala Val Glu Arq Ala Cys 120 125 130 tqactatcca gtagccacgg aga 516 <210> 152 <211> 131 (212> PRT <213> Corynebacteriun giutamicum <400> 152 Met Ile Ser Ile Gly Thr Asp Leu Val His Ile Ser Ala Phe Ala Giu 1 5 10 Gin Leu Ala Gin Pro Giy Ser Ser Phe Met Glu Val Phe Ser Ala Gly 25 Giu Arg Arg Lys Ala Asn Glu Arg Gin Ala Ser Arg Tyr Ala Giu His 40 Leu Ala Gly Arg Trp Ala Ala Lys Giu Ser Phe Ile Lys Ala Trp Ser 55 Gin Ala Ile Tyr Gly Gin Pro Pro Val Ile Ala Giu Giu Ala Val Val 70 75 Trp Arg Asp Ile Giu Val Arg Ala Asp Ala Trp Gly Arg Val Ala Ile 90 Giu Leu Ala Pro Giu Leu Ala Ala Val Val Arg Giu Ser Ile Gly Giu 100 105 110 Phe Ser Ser Ser Leu Ser Ile Ser His Asp Gly Asp Tyr Ala Val Giu 115 120 125 Arq Ala Cys 130 <210> <211> <212> <213> <220> <221> <222> <223> 153 543 DNA Corynebacterlu glutamicum CDS (101). (520) RXN 03132 <400> 153 taacttattt atacataaaa acacaataaa aaccgcacac ccctagactg caaaaaatgq ttaggctaac cttatttcca gcggcgaaac ttcaataaat atg aat gtg aat caa 11 Met Asn Val Asn Gin cag ttg gga gcc Gin Leu Gly Ala acc gcc atg aac Thr Ala Met Asn cct gag acc gca Pro Glu Thr Ala acc gtc Thr Val ctt cgc tcc Leu Arg Ser aaa agc cgc Lys Ser Arg tct gac atg gtt Ser Asp Met Val agc Ser acc gaa acc aat Thr Glii Thr Asn ccg cgc cgt Pro Arg Arg gCc tgg CCC Ala Trp Pro ctc gag cag ctc Leu Glu Gin Leu tac gcc acc gc Tyr Ala Thr Ala cac tac His Tyr ccc att gcc cac Pro Ile Ala His gcc cag gcc gcg Ala Gln Ala Ala gt g Val1 caa tta gcc agg Gin Leu Ala Arg cca Pro atg cgg qtt ttt Met Arq Val Phe gag Giu ctc cag agc ttt Leu Gin Ser Phe ggc qtc aag cac Gly Val Lys His 307 355 403 451 ctc cac cac atc Leu His His Ile ctt cgC ccc gcc Leu Arg Pro Ala gaa tgg gac atc Glu Trp Asp Ile atg gga Met Gly 100 ttt ccc gaa Phe Pro Giu gac ccc cct Asp Pro Pro 120 ccc gac acg ctg Pro Asp Thr Leu ccc att ttg ctc agt gac ctg cgc Pro Ile Leu Leu Ser Asp Leu Arg 110 115 tac gcc acc act Tyr Ala Thr Thr gct Al a 125 qtg cca cct caa Val Pro Pro Gin t cc Ser 130 acg cca cgc Thr Pro Arg tcc gct cac cga tcc aca. Ser Ala His Arg Ser Thr 135 <210> 154 <211> 140 <212> PRT tgacqcttcc aggcgccacc gcg <213> Corynebacterium glutamicun <400> 154 Met Asn Val Asn Gin Gin Leu Gly Ala Arg Thr Ala Met Asn His Pro 1 5 10 Giu Thr Ala Thr Val Leu Arg Ser Ile Ser Asp Met Val Ser Thr Glu 25 Thr Asn Pro Arq Arg Lys Ser Arg Leu Glu Gin Leu Ile Tyr Ala Thr 40 Ala Ser Ala Trp Pro His Tyr Pro Ile Ala His Ala Ala Gin Ala Ala 55 Val Gin Leu Ala Arg Pro Met Arg Val Phe Glu Leu Gin Ser Phe Giu 70 75 Gly Val Lys His Ala Leo His His Ile Asp Leo Arg Pro Ala Leo Gbu 90 Trp Asp Ile Met Gly Phe Pro Gbu Ser Pro Asp Thr Leu Pro Ile Leu 100 105 110 Leu Ser Asp Leu Arg Asp Pro Pro Tyr Ala Thr Thr Ala Val Pro Pro 115 120 125 Gin Ser Thr Pro Arg Ser Ala His Arg Ser Thr His 130 135 140 <210> 155 <211> 461 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> <223> RXN03157 <400> 155 ggc cac ctc gac atc gtg acc cgc gcc gcc gcg caa ttt agc gaa gtc 48 Gly His Leu Asp Ile Val Thr Arg Ala Ala Ala Gin Phe Ser Giu Val 1 5 10 acc atc ttg gtc acc gcc: aac ccc aac aaa aac tca qga ctg ttc acc 96 Thr Ile Leo Val Thr Ala Asn Pro Asn Lys Asn Ser Gly Leo Phe Thr 25 gtc gca gaa cgc atg gat ctc atc cgc gaa tcc acc gca cac ctg gac 144 Val Ala Gbu Arg Met Asp Leo Ile Arg Glu Ser Thr Ala His Leo Asp 40 aac gta aaa gta gac act tgg gcc tca ctg ctc gtg gat tac acc acc 192 Asn Val Lys Val Asp Thr Trp Ala Ser Leo Leo Val Asp Tyr Thr Thr 55 gaa cat ggc atc ggc gcc cta qtc aaa ggc ctg cga agc tcc ctc gac 240 Gbu His Gly Ile Gly Ala Leo Val Lys Gly Leu Arg Ser Ser Leo Asp 70 '75 tac qaa tac gag ctc ccc atg gca cag atg aac agg cga ctc acg gqc 288 Tyr Gbu Tyr Gbu Leo Pro Met Ala Gin Met Asn Arg Arg Leo Thr Gly 90 gta gac acc ttc ttc ctc ctc acc gac gag aaa tac ggc tac gtc agc Val Asp Thr Phe Phe Leu Leu Thr Asp Glu Lys Tyr Gly Tyr Val Ser 100 105 110 tcc aca ctg tgc aaa gaa gtt gcc cgc ttc ggt ggc gat gte tcc ggc Ser Thr Leu Cys Lys Glu Val Ala Arg Phe Gly Gly Asp Val Ser Gly 115 120 125 ctc cta cct gag gta gtg gca aaa gcc gtg aca gaa aaa tac agc aac Leu Leu Pro Giu Val Val Ala.Lys Ala Val Thr Giu Lys Tyr Ser Asn 130 135 140 cag cac tagtttcttt tgcatcaagc gtc Gin His 145 (210> 156 <211> 146 <212> PRT <213> Corynebacterium giutamicum <400> 156 Gly His Leu Asp Ile Val Thr Arg Ala Ala Ala Gin Phe Ser Giu Val 336 384 432 461 1 5 Thr Ile Leu Vai Thr Ala Asn Pro Asn 25 Val Ala Glu Arg Met Asp Leu Ile Arg Asn Val Lys Val Asp Thr Trp Ala Ser 55 Giu His Gly Ile Gly Ala Leu Val Lys 70 Tyr Giu Tyr Glu Leu Pro Met Ala Gin Val Asp Thr Phe Phe Leu Leu Thr Asp 100 105 Ser Thr Leu Cys Lys Giu Val Ala Arg 115 120 Leu Leu Pro Giu Vai Vai Ala Lys Ala 130 135 Gin His 145 <210> 157 <211> 1206 <212> DNA <213> Corynebacterium giutamicum 10 Lys Glu Leu Gly Met 90 Giu Phe Val1 Asn Ser Le u Leu 75 As n Lys Gly Thr Ser Thr Val1 Arg Arq Tyr Gly Giu 140 Leu His Tyr Ser Leu Tyr 110 Val1 Tyr Phe Leu Thr Leu Thr Val1 Ser Ser Thr Asp Thr Asp Gly Ser Gly As n <220> <221> CDS <222> (101)..(1183) <223> RXN00934 ccaacccctg tggtttggtg atttggatcc ggagcgtctc aaatgttcac aaaccggtgg cattacagga ggacaattag aagcgctcta gggagcagac gt g Val1 1 cga att gga Arg Ile Gly gtc tgc ccg tac Val Cys Pro Tyr ttc gat gag ccg ggc ggt gtt caa gcg Phe Asp Giu Pro Gly Gly Val Giln Ala cat atc His Ile ctt gac tta Leu Asp Leu ctt ggt ccg teu Gly Pro cga acc ttc att Arg Thr Phe Ile caa qgc cat gag Gin Gly His Giu gtt cag gtg Vai Gin Val gtg gtg cgc Val Val Arg tgt agt gcg gat acg cag gtg ccc gat Cys Ser Ala Asp Thr Gin Val Pro Asp ggt ggt Gly Gly ggc agc atc ccg Giy Ser Ile Pro ccg tac aat ggc Pro Tyr Asn Gly t cg Ser gtt gcc cgc ttg Val Aia Arg Leu a gc Ser 7 0 ttt ggg ccg aaa Phe Gly Pro Lys atg Met 75 ttc aag gcc gtg Phe Lys Ala Val acg ttc ctc cgc Thr Phe Leu Arg gaa Giu ggc aac ttc gat Gly Asn Phe Asp ctg cat atc cat Leu His Ile his ccg aat tca cca Pro Asn Ser Pro agt ttt Ser Phe 100 tcc atg gcg Ser Met Aia cac gcc tcc His Aia Ser 120 gcg Al a 105 cta cgc ttt gcg Leu Arg Phe Ala ggc ccc atc gtt Gly Pro Ile Val gct act tac Ala Thr Tyr 115 tta cca qtg Leu Pro Val agt agc gqa tcg Ser Ser Gly Ser aag Lys 125 ctq ctc aag gct Leu Leu Lys Ala ctt tcg Leu Ser 135 ccc atg ctg gag Pro Met Leu Giu gtg cgc gca ggc Val Arg Ala Gly gcc gtg tct gaa Ala Val Ser Giu atg Met 150 gct cgg cgc tgg Ala Arg Arg Trp cag Gin 155 gtg gag caa gtc Val Giu Gin Val gqC Gly 160 ggc gat ccc gtg Gly Asp Pro Val ct g Le u 165 atc ccc aac ggg Ile Pro Asn Gly gag acc tcc atg Giu Thr Ser Met aaa gcc gcg cgc Lys Ala Ala Arg caa atc Gin Ile 180 gaa ccg aat Giu Pro Asn cct gta gag atc Pro Vai Gu Ile ttt ttg ggt cgc Phe Leu Gly Arg ctc gat gag Leu Asp Giu 195 tcc cyc aaa gyc ctc gac atc ctc ctq cgc gct ctg acc agg ctg gat Ser Arg Lys Gly Leu Asp Ile Leu Leu Arg Ala Leu Thr Arg Leu Asp 200 egc Arg gce Ala 230 ate Ile agc Ser gte Val1 gca Ala gcc Al a 310 ctt Leu gt a ValI gtg Val1 ccg Pro 215 ggc Gly tta Leu ttc Ph e gee Ala eag Gin 295 aaa Lys ate Ile tee Se r agg Arg ttt acc Phe Thr ate aac Ile Asn ggt cgc Gly Arg ggc atc Gly Ile 265 agc qac Ser Asp 280 eca gcg Pro Ala aaa ctt Lys Leu gec geg Ala Ala ace cag Thr Gin 345 ctt gqa Leu Gly 360 acc Thr gtg Val1 235 gac Asp cta Leu qaa Glu gtg Val1 geg Ala 315 eta Le u atg gte ValI 220 ggc Gly ate Ile gt t Val1 geg Ala eta Leu 300 et t Leu aag Lys geca 205 att Ile c Arg tat T yr gaa Giu ttc Phe 285 ttt Phe ato Ile ege Arg gte gge Gly gte Vali gtc Val1 9cg Ala 270 tcc Ser aaa Lys gac Asp gea Ala tat Tyr 3 ggc gge ace Gly Gly Thr 225 age gat gag Ser Asp Gin 240 gea ccc aac Ala Pro Asn 255 atg gee geg Met Ala Ala ctg gte ace Leu Vai Thr ace gge tea Thr Gly Ser 305 gac eec tcc Asp Pro Ser 320 aae gee tae Asn Ala Tyr 335 gaa aee att Glu Thr Ile ega Arg aag Lys gge Gly t ge Cys 275 tet Ser gee Ala cgt Arg tgg Trp ate Ile gaa Gin gea Ala gge Gly 260 get Ala gaa Gin gac Asp tee Ser t eq Ser 340 gac Asp gte ValI gca Ala 245 gaa Giu gte Val1 gce Al a eta Le u a eq Thr 325 aea Thr aaa Lys 787 835 883 931 979 1027 1075 1123 1171 Val Met Ala Val tgaeeettgt ttaceteete ate 1206 <210> 158 <211> 361 <212> PRT <213> Corynebacterium giutaijum <400> 158 Val Arg Ilie Gly Met Val Cys Pro Tyr 1 5 Val Gin Ala His Ile Len Asp Len Ala 25 His Gin Vai Gin Val Leu Gly Pro Cys 40 Asp Phe Val Val Arg Giy Gly Gly Ser 55 Se r 10 Arg Ser Ile Phe Asp Gin Pro Gly Gly Thr Phe Ile Ala Gin Gly Ala Asp Thr Gin Vai Pro Pro Ile Pro Tyr Asn Gly Ser Val Ala Arg Leu Ser Phe Gly Pro Lys Met Phe Lys Ala Val Arg 70 75 Thr Phe Leu Arg Glu Gly Asn Phe Asp Val Leu His Ile His Glu Pro 90 Asn Ser Pro Ser Phe Ser Met Ala Ala Leu Arg Phe Ala Glu Gly Pro 100 105 110 Ile Val Ala Thr Tyr His Ala Ser Ser Ser Gly Ser Lys Leu Leu Lys 115 120 125 Ala Phe Leu Pro Val Leu Ser Pro Met Leu Glu Lys Val Arg Ala Gly 130 135 140 Ile Ala Val Ser Glu Met Ala Arg Arg Trp Gin Val Glu Gin Val Gly 145 150 155 160 Gly Asp Pro Val Leu Ile Pro Asn Gly Val Glu Thr Ser Met Phe Lys 165 170 175 Ala Ala Arg Gin Ile Glu Pro Asn Asp Pro Val Glu Ile Val Phe Leu 180 185 190 Gly Arg Leu Asp Glu Ser Arg Lys Gly Leu Asp Ile Leu Leu Arg Ala 195 200 205 Leu Thr Arg Leu Asp Arg Pro Phe Thr Cys Thr Val Ile Gly Gly Gly 210 215 220 Thr Pro Arg Glu Val Ala Gly Ile Asn Phe Val Gly Arg Val Ser Asp 225 230 235 240 Glu Glu Lys Ala Ala Ile Leu Gly Arg Ala Asp Ile Tyr Val Ala Pro 245 250 255 Asn Thr Gly Gly Glu Ser Phe Gly Ile Val Leu Val Glu Ala Met Ala 260 265 270 Ala Gly Cys Ala Val Val Ala Ser Asp Leu Glu Ala Phe Ser Leu Val 275 280 285 Thr Asp Ser Glu Ala Ala Gin Pro Ala Gly Val Leu Phe Lys Thr Gly 290 295 300 Ser Asp Ala Asp Leu Ala Lys Lys Leu Gin Ala Leu Ile Asp Asp Pro 305 310 315 320 Ser Ser Arg Ser Thr Leu Ile Ala Ala Gly Leu Lys Arg Ala Asn Ala 325 330 335 Tyr Asp Trp Ser Thr Val Ser Thr Gin Val Met Ala Val Tyr Glu Thr 340 345 350 Ile Ala Ile Asp Lys Val Arg Leu Gly 355 360 <210> 159 <211> 1320 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1297) <223> RXN00792 <400> 159 cacctttggt gctgagccag gccacccagg cctttgaggt gcggccacgt ggctgcccaa tacacgatcg gatccttgtc tggcgcagat gccttaaacg atg agc caa gaa att 11~ Met Ser Gin Giu Ile ttg agc cat ttt Leu Ser His Phe g ca Ala ccc gca tta gag Pro Ala Leu Glu og c Arg 15 att cga agc ggc Ile Arg Ser Gly gcc gtc Ala Val gag cgc gaa Giu Arg Giu gta gag cta Vai Giu Leu cag Gin cag cgc gcc ttg Gin Arg Ala Leu gtg gaa gag att Val Giu Giu Ile aaa gag ctg Lys Glu Leu cta ggc ggt Leu Gly Gly ggt ttt act ggg Gly Phe Thr Gly cga gtg ccc gaa Arg Val Pro Glu gcg ggc Ala Gly gct tcc ctg gaa Ala Ser Leu Giu agc Ser 60 gta gtt gag tta Val Val Glu Leu ctg Leu atc gag atc gcg Ile Giu Ile Ala gcc gat tcc aat Ala Asp Ser Asn atc Ile gcc caa gcc ctg Ala Gin Ala Leu gga cat ttt gcc Gly His Phe Ala 307 355 403 gtg gaa cta ctc Val Glu Leu Leu gaa, gcg ccg gag Glu Ala Pro Glu gaa ttc cgc acc Giu Phe Arg Thr cat tgg His Trp 100 ctg cgc gaa Leu Arg Glu aaa cgc ggc Lys Arg Gly 120 gtc ValI 105 gcc acc gga aga Ala Thr Gly Arg ctt Leu 110 gtg ggc aac gcc Val Gly Asn Ala gaa agt gag Glu Ser Glu 115 gag gtg gag Glu Val Glu gtt tac ggc gat Val Tyr Gly Asp ccg Pro 125 cag acc ttc atc Gin Thr Phe Ile ga t Asp 130 act gaa Thr Giu 135 aac gga ccq att Asn Gly Pro Ile gtg ctc aac ggc Val Leu Asn Gly aag ttt tat acc Lys Phe Tyr Thr ggc acc tat ttt Gly Thr Tyr Phe gcg Al a 155 gac tac acc tgg Asp Tyr Thr Trp acc Thr 160 acc gcg ctg ctg Thr Ala Leu Leu cgc Arg 165 aac ctt aac ggc Asn Leu Asn Gly gaa act ttg gtc Giu Thr Leu Val ttg ccg gtc gat Leu Pro Val Asp ctg cac Leu His 180 gcg ccg ggc gtg gat gtt gct gat gat tgg agc ggg ttt ggg caa aag Ala Pro Gly Val Asp Val Ala Asp Asp Trp Ser Gly Phe Gly Gin Lys etc acc gcc Leu Thr Ala 200 tct gga acg ace Ser Gly Thr Thr acg Thr 205 ttt aaa gac ctg Phe Lys Asp Leu gag Glu 210 gtg gat ccg Val Asp Pro cgg tgg Arg Trp 215 atc att cca cgc Ile Ile Pro Arg gat gcg ccc acg Asp Ala Pro Thr gtg tgg acg tat Val Trp Thr Tyr etg Leu 230 cag ctg agc etg Gin Leu Ser Leu Ctg Le u 235 ace gtg etg gtt Thr Val Leu Val ggC Gly 240 agt gcc gca. gca Ser Ala Ala Ala gtc gat gag gtg Val Asp Glu Val gcc cgc gcc caa Ala Arg Ala Gin tcc acc aga aat Ser Thr Arg Asn geg tgg Ala Trp 260 aae ect ggc Asn Pro Gly ggc gac gca Gly Asp Ala 280 gag cgc cgc agc Glu Arg Arg Ser ga t Asp 270 ccg gee gca ace Pro Ala Ala Thr ata gcg ate Ile Ala Ile 275 ctt ctc gac Leu Leu Asp cge age ega gte Arg Ser Arg Val gtt att cgt gga Val Ile Arg Gly gee ace Ala Thr 295 egc eac gtt tee Arg His Val Ser aae As n 300 gee gee aeg ate Ala Ala Thr Ile aee cee gaa gee Thr Pro Glu Ala ttc Phe 310 aac gag geg gae Asn Glu Ala Asp att gtt gea geg Ile Val Ala Ala etc Leu 320 tgg ccc ate gte Trp Pro Ile Val tee Ser 325 1027 1075 1123 gga caa get ttg Gly Gin Ala Leu gtg aca tee aae Val Thr Ser Asn tte gat gcg gtg Phe Asp Ala Val ggt gea Gly Ala 340 tet gea gtg Ser Ala Val cgt ace gtg Arg Thr Val 360 ct t Leu 345 ggt gag eat tee Gly Glu His Ser att gat Ile Asp 350 ege cac tgg Arg His Trp ege aat gtg Arg Asn Val 355 aat gea gtg Asn Ala Val tee tea aae aae Ser Ser Asn Asn gtg ttc etg gee Val Phe Leu Ala 1171 1219 1267 1317 ggg gag Gly Glu 375 tat gee etc aae Tyr Ala Leu Asn 9gC Gly 380 act cet gtg ggt Thr Pro Val Gly aac att ggt aaa Asn Ile Gly Lys etg age egt ceg Leu Ser Arg Pro age eta age age Ser Leu Ser Ser tagaegtgtg atttcgctgg 1320 <210> 160 <211> 399 <212> PRT <213> Corynebacterium glutarnicum <400> 160 Met Ser Gin Glu Ile Leu Ser His Phe Ala Pro Ala Leu Giu Arg Ile 1 5 10 Arg Ser Gly Ala Val Glu Arg Glu Gin Gin Arg Ala Leu Pro Val Glu 25 Glu Ile Lys Glu Leu Val Giu Leu Giy Phe Thr Gly Leu Arg Val Pro 40 Giu Glu Leu Gly Gly Ala Gly Ala Ser Leu Giu Ser Val Val Glu Leu 55 Leu Ile Giu Ile Ala Gly Ala Asp Ser Asn Ile Ala Gin Aia Leu Arg 70 75 Gly His Phe Ala Phe Val Glu Leu Leu Leu Giu Ala Pro Glu Ser Glu 90 Phe Arg Thr His Trp Leu Arg Glu Val Ala Thr Gly Arg Leu Val Gly 100 105 110 Asn Ala Giu Ser Giu Lys Arg Gly Val Tyr Gly Asp Pro Gln Thr Phe 115 120 125 Ile Asp Glu Val Giu Thr Glu Asn Gly Pro Ile Phe Val Leu Asn Gly 130 135 140 Thr Lys Phe Tyr Thr Thr Gly Thr Tyr Phe Ala Asp Tyr Thr Trp Thr 145 150 155 160 Thr Ala Leu Leu Arg Asn Leu Asn Gly Gin Glu Thr Leu Val Ser Leu 165 170 175 Pro Val Asp Leu His Ala Pro Gly Vai Asp Val Ala Asp Asp Trp Ser 180 185 190 Gly Phe-Gly Gin Lys Leu Thr Ala Ser Giy Thr Thr Thr Phe Lys Asp 195 200 205 Leu Giu Val Asp Pro Arg Trp Ile Ile Pro Arq Thr Asp Ala Pro Thr 210 215 220 Leu Val Trp Thr Tyr Leu Gin Leu Ser Leu Leu Thr Val Leu Val Gly 225 230 235 240 Ser Ala Ala Ala Ala Val Asp Glu Val Val Ala Arg Ala Gin Ser Ser 245 250 255 Thr Arg Asn Ala Trp Asn Pro Gly Val Glu Arg Arg Ser Asp Pro Ala 260 265 270 Ala Thr Ile Ala Ile Gly Asp Ala Arg Ser Arg Val Thr Val Ile Arg 275 280 285 Gly Ala Leu Leu Asp Ala Thr Arg His Val Ser Asn Ala Ala Thr Ile 290 295 300 Val Thr Pro Glu Ala Phe-Asn Glu Ala Asp Ala Ile Val Ala Ala Leu 305 310 315 320 Trp Pro Ile Val Ser Gly Gin Ala Leu Val Val 325 330 Asp Ala Val Gly Ala Ser Ala Val Leu Gly Glu 340 345 His Trp Arg Asn Val Arg Thr Val Ser Ser Asn 355 360 Ala Lys Asn Ala Val Gly Giu Tyr Ala Leu Asn 370 375 Thr Asn Ile Gly Lys Ala Len Ser Arg Pro Val 385 390 395 <210> 161 <211> 969 <212> DNA <213> Corynehacterium gintamicum <220> <221> COS <222> (946) <223> RXN00931 <400> 161 ccgtaaccta atcqttgaaa catcacctta ttgctgggct Thr His Asn Gly 380 Ser Ser Ser Pro 365 Thr Leu Val Phe 335 Asp Arg Phe Len Val Gly Ser ttgcacgcta ctctttgtga gtaacctcac cgaagtgcat aaattaattg ggagtgatca gtg aaa act att gaa Val Lys Thr Ile Glu att Ile atc Ile gct Ala t ct Ser att Ile t cg Se r ttg Leu tat Tyr gca Ala qgc Gly gtg Val ggc Gly gaa Giu gcc Ala a cg Thr ttt Phe 60 cga Arg caa Gin atc gac Ile Asp agg act Arg Thr cat act His Thr ata gct Ile Ala gtt cgc Val Arg gac ggc Asp Gly gaa ggc Gin Gly 110 cgc gat Arg Asp 15 ttc ggt Phe Gly gtt gat Val Asp cct ggt Pro Gly gac gga Asp Gly gaa gta Gin Val 95 att gag Ile Gin .1 att Ile Gly aaa Lys gat Asp 65 aaa Lys a tc Ile c ac His tac Tyr ca g Gin gcc Ala 50 cca Pro agc Se r ttc Ph e atg Met cgt Arg gtc Val1 35 ttt Phe aca Thr tac Tyr agc Ser gac Asp 115 ggt Gly 20 gct Aia act Thr gca Ala gtc Val atg Met 100 a ag Lys ccc Pro gcc Al a Val1 ccc Pro acc Thr cag Gin atg Met 115 163 211 259 307 355 403 451 gcc agc ttt cat cgt ggg gat Ala Ser Phe His Arg Gly Asp 105 cgt aaa gtt Arg Lys Val 120 oca gct cot gat gag atc aag gga aca Pro Ala Pro Asp Glu Ile Lys Gly Thr gaa cgt atg Giu Arg Met ccg atc Pro Ile 135 tca agt agg cga Ser Ser Arg Arg ott gat gaa tgg Leu Asp Giu Trp gcg Ala 145 gaa tgg gat atc Giu Trp Asp Ile gtt att ccq cag Val Ilie Pro Gin ga t Asp 155 caa tta qaa etc Gin Leu Giu Leu gat ttc aco got Asp Phe Thr Ala gag caa got gtq Giu Gin Ala Val att cgg tgc acc Ile Arg Cys Thr gat Ott ccg gat Asp Leu Pro Asp aat ccc Asn Pro 180 aco ttc cac Thr Phe His cat agt goo His Ser Ala 200 cag Gin 185 tgc tca ctq act Gys Ser Leu Thr tat Tyr 190 ctg too gat atg Leu Ser Asp Met act ttg ctg Thr Leu Leu 195 atg goc toa Met Ala Ser cig gtg oca cac Leu Val Pro His ggt gag aaa atg Gly Giu Lys Met ott gat Leu Asp 215 cac got gtg tgq His Ala Val Trp ttc Phe 220 otq ogt 000 tto Leu Arg Pro Phe ogo Arq 225 gto gat gaa tgg Val Asp Giu Trp ttg Leu 230 ott tat gat cag Leu Tyr Asp Gin cgo Arg 235 tot oca tog gc Ser Pro Ser Ala agt ggg oga 900 Ser Giy Arg Ala act oac ggg ogq Thr His Gly Arg tto aac cag cag Phe Asn Gin Gin gga Gly 255 gat ttg gto got Asp Leu Val Ala att gtc Ile Val 260 aat caa gag Asn Gin Giu gga Gly 265 atg aoc cgc aca Met Thr Arg Thr ot 0 Le u 270 oao gag ggt gog His Giu Gly Ala caa tca att Gin Ser Ile 275 ccg atg cgc aaa gao Pro Met Arg Lys Asp 280 taaaatgcag cgaacttgaa gat <210> 162 <211> 282 <212> PRT <z213> Corynebacterium giutamioum <400> 162 Val Lys Thr Ile Giu Asp Ile Leu Thr Leu 1 5 10 Giu Giu Ile Asp Arg Asp Ile Tyr Arg Gly Pro Val Ile Giu Ser 25 Gly Gin Vai Ala Ala Gin Ala Leu Val Tyr Leu Ala Arg Thr Phe Gly Thr Val Asp Ala Ala Thr Lys Ala Phe Thr Val His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly 55 Asp Pro Thr Ala Pro Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly 70 75 Lys Ser Tyr Val Thr Arg Ser Val Arg Gly Ile Gin Asp Gly Giu Val 90 Ile Phe Ser Met Gin Ala Ser Phe His Arg Gly Asp Giu Gly Ile Glu 100 105 110 His Met Asp Lys Met Arg Lys Val Pro Ala Pro Asp Giu Ile Lys Gly 115 120 125 Thr Val Giu Arg Met Pro Ile Ser Ser Arg Arg Val Leu Asp Giu Trp 130 135 140 Ala Glu Trp Asp Ile Arg Vai Ile Pro Gin Asp Gin Leu Giu Leu Ser 145 150 155 160 Asp Phe Thr Aia Thr Giu Gin Ala Vai Trp Ile Arg Cys Thr Ala Asp 165 170 175 Leu Pro Asp Asn Pro Thr Phe His Gin Cys Ser Leu Thr Tyr Leu Ser 180 185 190 Asp Met Thr Leu Leu His Ser Ala Leu Val Pro His Pro Gly Giu Lys 195 200 205 Met Gin Met Ala Ser Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe 210 215 .220 Arg Val Asp Giu Trp Leu Leu Tyr Asp Gin Arg Ser Pro Ser Ala Ser 225 230 235 240 Ser Giy Arg Ala Leu Thr His Gly Arq Lou Phe Asn Gin Gin Gly Asp 245 250 255 Leu Vai Ala Ile Val Asn Gin Giu Gly Met Thr Arg Thr Leu His Giu 260 265 270 Gly Ala Gin Ser Ile Pro Met Arg Lys Asp 275 280 <210> 163 <211> 969 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101) (94 6) <223> FRXA00931 <400> 163 ccgtaaccta atcgttgaaa catcacctta ttgctgggct ttgcacgcta ctctttgtga gtaacctcac cgaaqtgcat aaattaattg qgagtgatca qtq aaa act att gaa 115 Val Lys Thr Ile Glu gat att ttg acc Asp Ile Leu Thr gaa gaa atc gao Giu Giu Ile Asp cgc Arg gat att tac cgt Asp Ile Tyr Arq ggt ccc Gly Pro gtt atc gaa Val Ile Giu caa gct tta Gin Ala Leu tat tta goc agg Tyr Leu Ala Arg ttc ggt ggc cag Phe Gly Gly Gin gtc gct gcc Val Ala Ala ttt act gtg Phe Thr Val 211 259 gta gca gca acg Val Ala Ala Thr act gtt gat aaa Thr Val Asp Lys 900 Ala cat tot His Ser ttg cat ggc tac Leu His Gly Tyr ttt Phe ata gct oct ggt Ile Ala Pro Gly cca aca gca ccc Pro Thr Ala Pro att tat tta gtg Ile Tyr Leu Val cga gtt cgc gac Arg Val Arg Asp aaa ago tao gtc Lys Ser Tyr Val 307 355 403 cgc tog gtg Cgt Arg Ser Val Arg atc caa gao ggo Ile Gin Asp Gly ga a Giu gta. ato ttc ago Val Ile Phe Ser atg cag Met Gin 100 goc ago ttt Ala Ser Phe cgt aaa gtt Arq Lys Val 120 oat His 105 ogt ggg gat gaa Arg Gly Asp Glu att gag cac atg Ile Giu His Met gao aag atg Asp Lys Met 115 gaa cgt atg Glu Arg Met 451 499 005 got cot gat Pro Ala Pro Asp ato aag gga aoa Ile Lys Gly Thr gt a Val 130 cog ato Pro Ile 135 tos agt agg oga Ser Ser Arg Arg gtg Val1 140 ott gat gaa tgg Leu Asp Glu'Trp gog Ala 145 gaa tgg gat atc Giu Trp Asp Ile ogc Arg 150 gtt att cog cag Val Ile Pro Gin ga t Asp 155 caa tta gas otc Gin Leu Giu Leu gat ttc soc gct Asp Phe Thr Ala gag oaa got gtg Giu Gin Ala Val stt ogg tgo aco Ile Arg Cys Thr got Al a 175 gat ctt cog gat Asp Leu Pro Asp aat coo Asn Pro 180 sco tto oac Thr Phe His cat agt gcc His Ser Ala 200 cag Gin 185 tgo toa ctg act Cys Ser Leu Thr otg too gat atg Leu Ser Asp Met act ttg otg Thr Leu Leu 195 atg goo tos Met Ala Ser otg gtg oca cac Leu Val Pro His ggt gag ass atg Gly Giu Lys Met ott gat Leu Asp 215 cao got gtg tgg His Ala Val Trp ttc Phe 220 ctg ogt occ tto Leu Arg Pro Phe og 0 Arg 225 gto gat gaa tgg Val Asp Giu Trp ctt tat gat cag Leu Tyr Asp Gin cgc Arg 235 tot csa tog gc Ser Pro Ser Ala toa Ser 240 agt 999 Oga gcc Ser Gly Arg Ala ttg be u 245 act cac ggg cgg Thr His Gly Arg aat caa gag gga Asn Gin Glu Gly 265 ccg atq cgc aaa Pro Met Arg Lys 280 ctt ttc aac cag cag gga gat ttg gtc gct att gtc Leu Phe Asn Gin Gin Gly Asp Leu Val Ala Ile Val 250 255 260 atg acc cgc aca ctc cac gag ggt gcg caa tca att Met Thr Arg Thr Leu His Giu Giy Ala Gin Ser Ile 270 275 gac taaaatgcaq cgaacttgaa gat Asp 883 931 969 <210> 164 <211> 282 (212> PRT <213> Corynebacterium giutamicum <400> 164 Val Lys Thr 1 Ile Tyr Arg Gly Gin Val Lys Ala The Asp Pro Thr Lys Ser Tyr Ile Phe Ser His Met Asp 115 Thr Val Giu 130 Ala Glu Trp 145 Asp Phe Thr Leu Pro Asp Asp Met Thr 195 Met Gin Met Ile Glu Asp Ile Leu Thr Gly Ala Thr Ala Val1 Met 100 Lys Arg Asp Al a As n 180 Le u Ala 5 Pro Ala ValI Pro Thr Gin Met Met Ile Thr 165 Pro Leu Ser ile Ala Ser 55 Ile Ser Ser Lys Ile 135 Val Gin Phe Ser Asp 215 Glu Le u Leu Tyr Val1 Phe Val1 120 Ser Ile Al a His Al a 200 His Ser 25 Val1 His Leu Arg His 105 Pro Ser Pro Val1 Gin 185 Leu Ala Le u 10 Tyr Ala Gly Val Gly 90 Arg Al a Arg Gin Trp 170 Cys Val1 Val1 Giu Leu Ala T yr Asp 75 Ile Gly Pro Arq Asp 155 Ile Ser Pro T rp Glu Ala Thr Phe Arg Gin Asp Asp ValI 140 Gin Arg Le u His Phe 220 Asp Thr Thr Al a Arg Gi y Gly 110 Ile Asp Giu Th r Tyr 190 Gi y Ar g Arg Phe Val Pro Asp Giu Ile Lys Giu Leu Ala 175 Leu Glu Pro Asp Gly Asp Gly Gly Val1 Gi u Gly Trp Se r 160 As p Se r Lys Ph e Arg Val Asp Giu Trp Leu Leu Tyr Asp Gin Arg Ser Pro Ser Ala Ser 225 230 235 240 Ser Gly Arg Ala Leu Thr His Gly Arg Leu Phe Asn Gin Gin Gly Asp 245 250 255 Leu Val Ala Ile Val Asn Gin Glu Gly Met Thr Arg Thr Leu His Giu 260 265 270 Gly Ala Gin Ser Ile Pro Met Arg Lys Asp 275 280 (210> 165 <211> 510 <212> DNA <213> Corynebacterium giutarnicum <220> <221> CDS <222> (101)..(487) <223> RXN01421 (400> 165 ttgatgcacg tgcagaaatc gtcggoggtc cgtggcacoo atctgttaag ggagactcgg ttactgcagg gatootgcga gatcgagtaa aogcctaaag atg acg tcg aaa agc Met Thr Ser Lys Ser att Ile ctc Le u gtg Val1 gtC Val1 tcc Ser aat Asn cac His act Thr agc Ser gcg Al a tat Tyr ccc Pro gga Gly Val1 ttg Le u a ca Thr ggo aag Giy Lys gog ctc Ala Leu cog ttc Pro Phe atg cag Met Gin ttt ttg Phe Leu ct g tat Leu Tyr att gog Ile Ala 105 ggo att Gly Ile ogo Arg got Ala cag Gin ct g Leu atc Ile tac Tyr ttq Leu ctg Leu ttt Phe gaa Giu 45 got Ala tca Ser ogo Arg ttt Phe ot g Leu ccg Pro ttg Leu 30 otg Leu ggt Gly aat Asn ogo Arg at t Ile 110 att Ile tog Ser 15 oat His ttt Phe gt a Val1 ago Ser ato Ile 95 gag Glu ttg Leu 1 oto act gga gog Leu Thr Gly Ala gog ttg gtg ttt Ala Leu Val Phe goc aca ato cat Ala Thr Ile His aco ttc tto ttt Thr Phe Phe Phe cag oto aag ggc Gin Leu Lys Gly 80 aco aaq att tat Thr Lys Ile Tyr 9og tog gog aag Ala Ser Ala Lys 115 cgg Arg t tg Leu aaa Lys ato Ile atg Met 000 Pro 100 ttC Phe tgg Trp t cg Se r ttt Phe ttg Le u aag Lys atg Met acg Thr aco tgg gtg Thr Trp Val ogo gag Arg Giu taaagctgtg 120 125 gctgcggaat gcg 510 <210> 166 <211> 129 <212> PRT <213> Corynebacterium giutamicum <400> 166 Met Thr Ser Lys Ser Ile Ser Gly Lys Arg Pro Asn Leu Pro Ser Leu 1 5 10 Thr Gly Ala Arg Trp Leu Ala Ala Leu Ala Val Tyr Phe Leu His Ala 25 Leu Val Phe Leu Ser Val Tyr Pro Phe Gin Gin Ser Glu Leu Phe Ala 40 Thr Ile His Lys Phe Val Pro Met Gin Leu Gly Ser Ala Gly Val Thr 55 Phe Phe Phe Ile Leu Ser Gly Phe Leu Ile Tyr Trp Ser Asn Ser Gin 70 75 Leu Lys Gly Met Lys Asn Val Leu Tyr Tyr Cys Lys Arg Arg Ile Thr 90 Lys Ile Tyr Pro Met His Leu Ile Ala Leu Pro Met Phe Ile Giu Ala 100 105 110 Ser Ala Lys Phe Thr Thr Thr Gly Ile Thr Trp Val Leu Ile Leu Arg 115 120 125 Glu <210> 167 <211> 930 <212> DNA <213> Corynebacterium qiutamicum <220> <221> CDS <222> (101)..(907) <223> RXN02342 <400> 167 caggttcgtg ctgcgtgcgg gtagttttta aaggtaaaac tttttgggcg tgtcgccctt aaaqcgcgct tttcqacqcg accccactac attggcttcc atg aac gtt gac att 115 Met Asn Val Asp Ile 1 tca cga tcc aga gag ccg cta aac gtt gag ctc ctg aag gaa aaa ttg 163 Ser Arg Ser Arg Giu Pro Leu Asn Val Glu Leu Leu Lys Giu Lys Leu 15 ctc caa aac ggt gac ttt ggc cag gtc att tac gaa aaa gtg aca ggc 211 Len Gin Asn tcc act aat Ser Thr Asn Asp Phe Gly Gin Ile Tyr Gin Lys Val Thr Gly got oca aac Ala Pro Asn got gao ttg ctg Ala Asp Leu Len ott gca ggt tot Len Ala Gly Ser 259 tgg acg Trp Thr gtg aaa act gtc Val Lys Thr Val ttt caa gat cat Phe Gin Asp His gcg Ala ogt ggg cga ctc Arg Gly Arg Len ggc Gly ot c Len ogo cog tgg tot Arg Pro Trp Ser gtt oaa cta tct Val Gin Len Ser gcc Ala oct gag ggt tco Pro Gin Gly Ser aca atc gtg tot Thr Ile Val Ser att gat caa gtg Ile Asp Gin Val gao Asp ogg att. ggo act Arg Ile Gly Thr ctc gcg gog Len Ala Ala gaa ggt gcc Gin Gly Ala 120 gga Gly 105 oto got gto atg Len Ala Val Met gog ttg aat gao Ala Len Asn Asp oto ggt gtg Len Gly Val 115 cao ggc aag His Gly Lys gga ctg aaa tgg Gly Len Lys Trp aao gat gtt oaa Asn Asp Val Gin aaa ctc Lys Len 135 tgc ggc ato otg Cys Gly Ile Len gaa goc aco ggc Gin Ala Thr Gly ttt Phe 145 gat too aco coa Asp Ser Thr Pro aea Thr 150 git qtc ate qgt Val Val Ile Giy tgg T rp 155 qg act aat ate Gly Thr Asn Ile ctg act aaa gag Len Thr Lys Gin ott cot gtt cot Len Pro Val Pro gca act too otc Ala Thr Ser Leu gca Ala 175 ttg gaa ggt gtt Len Gin Gly Val gaa gte Gin Val 180 gao aga aco Asp Arg Thr ctg gao caq Len Asp Gin 200 aca Thr 185 tto ott att aat Phe Len Ile Asn oto aca oat ctq Len Thr His Len oat act oga His Thr Arg 195 gat tao cgt Asp Tyr Arg 691 739 tgg cag ggt cca Trp Gin Gly Pro gtg gat tgg oto Val Asp Trp Len gog gta Ala Val 215 tgt too agt att Cys Ser Ser Ile caa gat gtt oga Gin Asp Vai Arg gtg Val1 225 Ott, ota cot ggg Len Len Pro Gly aaa gaa oto tta Lys Gin Len Len ggt Gly 235 gaa gog ato qgt Gin Ala Ile Gly gog act ggo gga Ala Thr Gly Gly 787 835 883 att ogt gtt cgo Ile Arg Val Arg gat Asp 250 got tog ggc aco Ala Ser Gly Thr gtt Val1 255 cac aco oto aac His Thr Len Asn goc ggt Ala Gly 260 gaa att acg cae ott ogo otg cag Gin Ile Thr His Len Arg Len Gin taaggtgaog gtatggggaa tto <210> 168 <211> 269 <212> PRT <213> Corynebacteriun qiutamicum <400> 168 Met Asn Val Asp Ile Ser Arg Ser Arg Glu Pro Leu Asn Val Glu Leu 1 5 10 Leu Lys Glu Lys Leu Leu Gin Asn Gly Asp Phe Gly Gin Val Ile Tyr 25 Giu Lys Val Thr Gly Ser Thr Asn Ala Asp Leu Leu Ala Leu Ala Gly 40 Ser Gly Ala Pro Asn Trp Thr Val Lys Thr Val Giu Phe Gin Asp His 55 Ala Arg Gly Arg Leu Gly Arg Pro Trp Ser Ala Pro Glu Giy Ser Gin 70 75 Thr Ile Val Ser Val Leu Val Gin Leu Ser Ile Asp Gin Val Asp Arq 90 Ile Gly Thr Ile Pro Leu Ala Ala Gly Leu Ala Val Met Asp Ala Leu 100 105 110 Asn Asp Leu Gly Val Glu Gly Ala Gly Leu Lys Trp Pro Asn Asp Val 115 120 125 Gin Ilie His Gly Lys Lys Leii Cys Gly Ile Leu Val Glu Ala Thr Gly 130 135 140 Phe Asp Ser Thr Pro Thr Val Val Ile Gly Trp Gly Thr Asn Ile Ser 145 150 155 160 Leu Thr Lys Glu Glu Leu Pro Val Pro His Ala Thr Ser Leu Ala Leu 165 170 175 Glu Gly Val Giu Val Asp Arg Thr Thr Phe Leu Ile Asn Met Leu Thr 180 185 190 His Leu His Thr Arg Leu Asp Gin Trp Gin Gly Pro Ser Vai Asp Trp 195 200 205 Leu Asp Asp Tyr Arg Ala Val Cys Ser Ser Ile Gly Gin Asp Val Arg 210 215 220 Val Leu Leu Pro Gly Asp Lys Glu Leu Leu Gly Giu Ala Ile Gly Val 225 230 235 240 Ala Thr Giy Gly Giu Ile Arg Val Arg Asp Ala Ser Gly Thr Val His 245 250 255 Thr Leu Asn Ala Gly Glu Ile Thr His Leu Arg Leu Gin 260 265 <210> 169 <211> 2762 <212> DNA <213> Coryriebacterium glutamicun <2 <221> CDS <222> (1)..(2739) <223> RXN00563 <400> 169 ttc tac aag gat ctc Phe Tyr Lys Asp Leu 1 5 tac gca cgt tcc Tyr Ala Arg Ser gca Ala 10 cgc qc acg gca Arg Gly Thr Ala gca ctg Ala Leu tgg atc gtg Trp Ile Val atc aac tgg Ile Asn Trp gcg Al a gct aac ttg agc Ala Asn Leu Ser tac tca gac atc Tyr Ser Asp Ile gac gcc atc Asp Ala Ile ggc gca tcc Gly Ala Ser gtc gga tcc gag Val Gly Ser Giu acc acc acc gtc Thr Thr Thr Val aag ctg Lys Leu gtc aag cca gct Val Lys Pro Ala ttq Le u 55 gtc cct acc ttg Val Pro Thr Leu Ct~g Le u ttc cca ttC gcg Phe Pro Phe Ala gca Ala cct cgc qtg tcc Pro Arg Val Ser gga Gly tcc atg gca gat Ser Met Ala Asp ggc cca cag gca Gly Pro Gln Ala tcc cag atg cga Ser Gin met Arg ctg ctc tqg tct Leu Leu Trp Ser gtt Val gag cgc ctc aic Glu Arg Leu Ile gca ggt Ala Gly ctt gcg cca Leu Ala Pro gtc atc cca Val Ile Pro 115 ttg Le u 100 qgc tcc tcc atc Giy Ser Ser Ile aac As n 105 gtg ggt cac cgc Val Giy His Arg ctg cac gtg Leu His Vai 110 gat ggt gca Asp Gly Ala gqt tca cca aac Gly Ser Pro Asn gga cgc ttc ggt Gly Arg Phe Gly ggc Gly 125 tac ggt Tyr Gly 130 gaa tcc aag gca Giu Ser Lys Ala ctc gac gcc gtg Leu Asp Ala Val acc cgt tgg aac Thr Arg Trp Asn gag caa gct gca Glu Gin Ala Ala t gg Trp 150 gga gca cac ac Gly Ala His Thr tcc Ser 155 ctc gtq cac gct Leu Val His Ala cac His 160 atc ggt tgg gtt Ile Gly Trp Val ggc acc ggc ctc Gly Thr Gly Leu qgc ggc aac gat Gly Gly Asn Asp cct ttg Pro Leu 175 gtc aag gca Val Lys Ala gc t Al a 180 gaa gaa gca ggc Giu Glu Ala Gly gtg Val1 185 gaa acc tac tcc Giu Thr Tyr Ser acc caa gaa Thr Gin Giu 190 att gca gag aaa ctq ctg tcc cag gca act tcc act gtt cgc gag cag Ile Ala Glu Lys Leu Leu Ser Gin Ala Thr Ser Thr Val Arg Giu Gin gea gca Ala Ala 210 tcc gcg cca atc Ser Ala Pro Ile acc Thr 215 gtc gac ttc act Val Asp Phe Thr ggc Gly 220 gga ctt ggt gaa Gly Leu Gly Giu gat ctg aac ctg Asp Leu Asn Leu gaa atg gca cgt Glu Met Ala Arg gaa gca get aag Glu Ala Ala Lys gct aac gca cca Ala Asn Ala Pro gtg Val 245 gtt gag gct cca Val Giu Ala Pro cgc Arg 250 aca gtg gea gea Thr Val Ala Ala ctg cca Leu Pro 255 act cct tac Thr Pro Tyr gtc acc caa Val Thr Gin 275 cca gtg gtt caa Pro Val Val Gln acc cct gat ttc Thr Pro Asp Phe gca ggt caa Ala Gly Gin 270 gcc ggc gag Ala Gly Glu aac ett gac gag Asn Leu Asp Glu gtc gtc atc gtt Val Val Ile Val ggc Gly 285 ctc ggc Leu Gly 290 cca ctg ggt tct Pro Leu Gly Ser gca Ala 295 cgt acg cgt ttc Arg Thr Arg Phe gac Asp 300 gcc gaa ctc aac Ala Giu Leu Asn ggt Gly 305 tcc ctc tcc gcc Ser Leu Ser Ala ggt gtc atc gaa Gly Val Ile Glu gca tgg acg atg Ala Trp, Thr Met gga GI y 320 912 960 1008 ctt atc cac tgg Leu Ile His Trp gat Asp 325 gaa gat cca aag Glu Asp Pro Lys eca Pro 330 ggc tgg tac gac Gly Trp Tyr Asp gac tcc Asp Ser 335 gac gac gca Asp Asp Ala gte atg gca Val Met Ala 355 gcc gaa gaa gac Ala Glu Glu Asp atc Ile 345 ttc gac cgc tac Phe Asp Arg Tyr cac gac gaa His Asp Giu 350 cct gag tac Pro Giu Tyr cgc gtt ggt gtc Arg Val Gly Val aag tac aat gac Lys Tyr Asn Asp ggc atg Gly Met 370 atc gac aac ttt Ile Asp Asn Phe gca Al a 375 cca gag ctg ace Pro Giu Leu Thr acc Thr 380 gtc tac ctc gac Val Tyr Leu Asp 1056 1104 1152 1200 1248 ca g Gin 385 gac etc ace ttc Asp Leu Thr Phe aac As n 390 gtg gga tee ege Val Giy Ser Arg gag gca ctg ace Giu Ala Leu Thr tac T yr 400 gte gac tee gag Val Asp Ser Giu eca Pro 405 gaa etc ace ttt Glu Leu Thr Phe get Ala 410 tet tte gac gaa Ser Phe Asp Glu gca gca Ala Ala 415 ggg gag tgg Gly Giu Trp ege ege atg Arg Arg Met 435 gte act ege aag Val Thr Arg Lys gca Ala 425 ggc tee qea ate Gly Ser Ala Ile ege qta cet Arg Vai Pro 430 cet aag gac Pro Lys Asp 1296 1344 geg atg ace ege Ala Met Thr Arg gtt ggt gga eag Val Gly Gly Gin ttc gac Phe Asp 450 cca got gtg tg Pro Ala Val Trp ggc Gly 455 att cca gct gac Ile Pro Ala Asp gtg gao aac ctgj Val Asp Asn Leu gac Asp 465 acc gtc gog ctg Thr Val Ala Leu tgg Trp 470 aac att qtc tgt Asn Ile Val Cys gtc gac gcc ttc Val Asp Ala Phe ct 9 Leu 480 1392 1440 1488 too got gga ttc Ser Ala Gly Phe oca gca gag ctg Pro Ala Glu Leu ct t Leu 490 gct tcc gtt cac Ala Ser Val His cca gca Pro Ala 495 ogc gtg too Arg Val Ser cgt qgc ato Arg Gly Ile 515 tot Ser 500 acc caa ggc ac Thr Gin Gly Thr atg ggc ggo atg Met Gly Gly Met gaa tco ctc Giu Ser Leu 510 goc aac gao Ala Asn Asp 1536 1584 tac gtc gac cgc Tyr Val Asp Arg ctg gca gag cca Leu Ala Glu Pro gtt otg Val Leu 530 cag gaa goa otg Gin Giu Ala Leu ccc Pro 535 aac gtt gtt goa Asn Val Val Ala cac gtc atg cag His Val Met Gln tcc Ser 545 tac gto ggt ggc Tyr Val Giy Gly gga cag atg ato Gly Gin Met Ile oca gto gca got. Pro Val Ala Ala gca aco gca got Ala Thr Ala Ala tot gtg gaa gaa Ser Val Giu Glu gca Ala 570 otg gao aag atc Leu Asp Lys Ile cgo ato Arg Ile 575 1632 1680 1728 1776 1824 ggc aag tc Gly Lys Ser gaa ggc atc Glu Gly Ile 595 gac Asp 580 ttc gtt qtc goa Phe Val Val Ala ggc ttc gat gco Gly Phe Asp Ala otg tcc gtt Leu Ser Val 590 gao too gca Asp Ser Ala aco ggc ttc ggo Thr Gly Phe Gly atg goa goa aco Met Ala Ala Thr gag atg Glu Met 610 gaa ggc aag gga Glu Gly Lys Gly att Ile 615 gag cac ogo tto Giu His Arg Phe too ogo qoo aao Ser Arg Ala Asn gao Asp 625 ogg ogo ogo ggt Arg Arg Arg Gly tto ato gaa too Phe Ile Giu Ser ggt ggo gga aoo Gly Gly Gly Thr gto Val1 640 1872 1920 1968 ott otg goa ogo Leu Leu Ala Arg toa oto goa got Ser Leu Ala Ala gao Asp 650 otg ggo ott oca Leu Gly Leu Pro gta oto Val Leu 655 ggt gto ato Gly Val Ile ato ooa gco Ile Pro Ala 675 gga Gly 660 tto goa gag too Phe Ala Glu Ser goa gat ggt goo Ala Asp Gly Ala cao aco too His Thr Ser 670 gat ggt gtg Asp Gly Val 2016 2064 ooa ggo oto ggt Pro Gly Leu Gly ott ggt got got Leu Gly Ala Ala ogo Arg 685 gaa tct Giu Ser 690 ege ctt gca gta Arg Leu Ala Val ctg cgt tc gte Leu Arg Ser Val gte tct gct gat Val Ser Ala Asp gag Glu 705 atc tcc att atc Ile Ser Ile Ile tcc Ser 710 aag cac gac ace Lys His Asp Thr tee Ser 715 ace aac geg aat Thr Asn Ala Asn 2112 2160 2208 eca aac gag tee Pro Asn Giu Ser gac Asp 725 etg cac gag egc Leu His Giu Arg gea tee get ate Ala Ser Ala Ile ggt egt Gly Arg 735 gea gac ggc Ala Asp Gly eac gee aag His Ala Lys 755 eeg atg tac gtg Pro Met Tyr Val att Ile 745 tee cag aag tea Ser Gin Lys Ser etc ace gga Leu Thr Gly 750 etc ace cag Leu Thr Gin 2256 2304 ggt ggt gca gca Gly Gly Ala Ala ttc cag atg ate Phe Gin Met Ile gte etc Val Leu 770 cga tee gga etg Arg Ser Gly Leu eca gee aae ege Pro Ala Asn Arg gca Al a 780 etc gac tge gtt Leu Asp Cys Val ga c Asp 785 cca gta ctg tee Pro Val Leu Ser aag Lys 790 eat tee eac etc His Ser His Leu tgg etg ege aag Trp Leu Arg Lys eta gac ctt egt Leu Asp Leu Arg aag gea eca aag Lys Ala Pro Lys ggt ett gtt ace Gly Leu Val Thr tee ett Ser Leu 815 2352 2400 2448 2496 2544 gge ttc gga Gly Phe Gly ttc tat gag Phe Tyr Giu 835 gte tee get etg Val Ser Ala Leu gt t Val1 825 geg att gtt cac Ala Ile Val His eca gac gee Pro Asp Ala 830 get gac gta Ala Asp Val gca gtt egt gtg Ala Val Arg Val cgt ggt get gag Arg Gly Ala Giu tgg ege Trp Arg 850 qea tee geg ate Ala Ser Ala Ile get ege gaa gaa gea gge ett cgt ace ate Ala Arg Glu Giu Ala Gly Leu Arg Thr Ile 855 860 2592 gte Val1 865 gee ggt atg eac Ala Gly Met His gge gta etg tac Gly Val Leu Tyr gaa Giu 875 ego eca gte gag Arg Pro Val Giu eg c Arg 880 2640 2688 aac etc ggt gte Asn Leu Gly Val eac His 885 gga gac gea get Gly Asp Ala Ala gaa gtt gaa get Glu Val Glu Ala gca gte Ala Val 895 etc etg gat Leu Leu Asp ego gee ege eta Arg Ala Arg Leu gac ggt gte etc Asp Gly Val Leu ego gee gaa Arg Ala Glu 910 2736 gge Gly tagttggtta ttgegttgag ccc 2762 <210> 170 <211> 913 <212> PRT <213> Corynebacterium glutamicum <400> 170 Phe Tyr Lys Asp Leu Tyr Ala Arg Ser Ala Arg Gly Thr Ala Ala Leu 1 5 10 Trp Ile Val Ala Ala Asn Leu Ser Ser Tyr Ser Asp Ile Asp Ala Ile 25 Ile Asn Trp Val Gly Ser Glu Gln Thr Thr Thr Val Asn Gly Ala Ser 40 Lys Leu Val Lys Pro Ala Leu Val Pro Thr Leu Leu Phe Pro Phe Ala 55 Ala Pro Arg Val Ser Gly Ser Met Ala Asp Ala Gly Pro Gin Ala Glu 70 75 Ser Gin Met Arg Leu Leu Leu Trp Ser Val Glu Arg Leu Ile Ala Gly 90 Leu Ala Pro Leu Gly Ser Ser Ile Asn Val Gly His Arg Leu His Val 100 105 110 Val Ile Pro Gly Ser Pro Asn Arg Gly Arg Phe Gly Gly Asp Gly Ala 115 120 125 Tyr Gly Glu Ser Lys Ala Ala Leu Asp Ala Val Val Thr Arg Trp Asn 130 135 140 Ala Glu Gin Ala Ala Trp Gly Ala His Thr Ser Leu Val His Ala His 145 150 155 160 Ile Gly Trp Val Arg Gly Thr Gly Leu Met Gly Gly Asn Asp Pro Leu 165 170 175 Val Lys Ala Ala Glu Glu Ala Gly Val Glu Thr Tyr Ser Thr Gin Glu 180 185 190 Ile Ala Glu Lys Leu Leu Ser Gin Ala Thr Ser Thr Val Arg Glu Gin 195 200 205 Ala Ala Ser Ala Pro Ile Thr Val Asp Phe Thr Gly Gly Leu Gly Glu 210 215 220 Ser Asp Leu Asn Leu Ala Glu Met Ala Arg Ala Glu Ala Ala Lys Ala 225 230 235 240 Ala Asn Ala Pro Val Val Glu Ala Pro Arg Thr Val Ala Ala Leu Pro 245 250 255 Thr Pro Tyr Arg Pro Val Val Gin Thr Thr Pro Asp Phe Ala Gly Gin 260 265 270 Val Thr Gin Asn Leu Asp Glu Met Val Val Ile Val Gly Ala Gly Glu 275 280 285 Leu Gly Pro Leu Gly Ser Ala Arg Thr Arg Phe Asp Ala Glu Leu Asn Gly Ser Leu Ser Ala Ala Gly Val Ile Glu Leu Ala Trp Thr Met Gly 305 310 315 320 Leu Ile His Trp Asp Glu Asp Pro Lys Pro Gly Trp Tyr Asp Asp Ser 325 330 335 Asp Asp Ala Val Ala Glu Glu Asp Ile Phe Asp Arg Tyr His Asp Glu 340 345 350 Val Met Ala Arg Val Gly Val Arg Lys Tyr Asn Asp Met Pro Glu Tyr 355 360 365 Gly Met Ile Asp Asn Phe Ala Pro Glu Leu Thr Thr Val Tyr Leu Asp 370 375 380 Gin Asp Leu Thr Phe Asn Val Gly Ser Arg Glu Glu Ala Leu Thr Tyr 385 390 395 400 Val Asp Ser Glu Pro Glu Leu Thr Phe Ala Ser Phe Asp Glu Ala Ala 405 410 415 Gly Glu Trp Lys Val Thr Arg Lys Ala Gly Ser Ala Ile Arg Val Pro 420 425 430 Arg Arg Met Ala Met Thr Arg Phe Val Gly Gly Gin Val Pro Lys Asp 435 440 445 Phe Asp Pro Ala Val Trp Gly Ile Pro Ala Asp Met Val Asp Asn Leu 450 455 460 Asp Thr Val Ala Leu Trp Asn Ile Val Cys Thr Val Asp Ala Phe Leu 465 470 475 480 Ser Ala Gly Phe Thr Pro Ala Glu Leu Leu Ala Ser Val His Pro Ala 485 490 495 Arg Val Ser Ser Thr Gin Gly Thr Gly Met Gly Gly Met Glu Ser Leu 500 505 510 Arg Gly Ile Tyr Val Asp Arg Ile Leu Ala Glu Pro Arg Ala Asn Asp 515 520 525 Val Leu Gin Glu Ala Leu Pro Asn Val Val Ala Ala His Val Met Gin 530 535 540 Ser Tyr Val Gly Gly Tyr Gly Gin Met Ile His Pro Val Ala Ala Cys 545 550 555 560 Ala Thr Ala Ala Val Ser Val Glu Glu Ala Leu Asp Lys Ile Arg Ile 565 570 575 Gly Lys Ser Asp Phe Val Val Ala Gly Gly Phe Asp Ala Leu Ser Val 580 585 590 Glu Gly Ile Thr Gly Phe Gly Asp Met Ala Ala Thr Ala Asp Ser Ala 595 600 605 Glu Met Glu Gly Lys Gly Ile Glu His Arg Phe Phe Ser Arg Ala Asn 610 615 620 Asp 625 Leu Gly Ile Glu Giu 705 Pro Ala His ValJ Asp 785 Leu Gly Ph e Trp Val1 865 Asn Arg Leu Val1 Pro Ser 690 Ile As n Asp Ala Leu 770 Pro Asp Phe T yr Arg 850 Ala Leu Arg Al a Ile Al a 675 Arg Ser Glu Gly Lys 755 Arg Val1 Leu Gi y Glu 835 Ala Gly Gly Arg Arg Gly 660 Pro Le u Ile Se r As n 740 Gi y Se r Le u Arq His 820 Al a Ser Met Val1 Gly 630 Ser Ala Le u Val1 Ser 710 Leu Met Al a Le u Lys 790 Lys Ser Arq Ile Gi y 870 Gly Phe Leu Glu Gly Ala 695 Lys His T yr Ala Val 775 His Ala Ala Val Ala 855 Gly Asp Ile Al a Se r Ala 680 Le u His Giu Val1 Ala 760 Pro Se r Pro Le u Al a 840 Arg Val1 Ala Glu Ala Phe 665 Leu Arg Asp Arg Ile 745 Phe Ala His Lys Val1 825 Arg Glu Leu Ala Ser Asp 650 Ala Gi y Ser Thr Ile 730 Se r Gin As n Leu Al a 810 Ala Gly Giu Tyr Lys 890 Glu 635 Le u Asp Al a ValI Ser 715 Ala Gl1n. Met Arg Val 795 Gly Ile Ala Ala Gi u 875 Glu Gi y Gly Gly Ala Gly 700 Thr Ser Lys Ile Al a 780 Trp Le u Val1 Glu Gly 860 Arg Val1 Gly Leu Al a Arg 685 Val1 As n Ala Ser Gly 765 Leu Leu Val1 His Ala 845 Leu Pro Glu Gly Pro His 670 Asp Ser Ala Ile Leu 750 Le u Asp Arg Thr Pro 830 Al a Arg Val1 Al a Thr Val1 655 Thr Gly Al a As n Gly 735 Thr Thr Cys L ys Ser 815 Asp Asp Thr Giu Ala 895 Val1 640 Le u Se r Val1 Asp Asp 720 Arg Gly Gin Val Pro 800 Le u Al a Val1 Ile Arg 880 Val Leu Leu Asp Ser Arg Ala Arg Leu Val Asp Gly Val Leu 900 905 Gly Arq Ala Giu 910 <210> 171 <211> 2937 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2914) <223> RXN02168 agggtttagt catotatttc ggctaogotc aogtaaoota ggtccaagaa gcccattcca agacttagga gctttatttc ogcattcgta agtggtcatg gtg agt att tct tca 11. Val Ser Ile Ser Ser otg aca ccg ctg Leu Thr Pro Leu cac His tct ttc aaa gag Ser Phe Lys Giu cca Pro 15 gca att ctg tac Ala Ile Leu Tyr goc ggt Ala Gly cag got tct Gin Ala Ser atc ace gca Ile Thr Ala tgg cag cag gtg Trp Gin Gin Val gct gat toe agc Ala Asp Ser Ser gaa gac cac Glu Asp His cgt gca aag Arg Ala Lys acq cac otg cgc Thr His Leu Arg gag Giu 45 ctc otg tot ego Leu Leu Ser Arg too Ser act gca Thr Ala oct ttc got cgo Pro Phe Ala Arg atc ace gcc atc Ile Thr Ala Ile oct ggc tca ctt Pro Gly Ser Leu ogt ott gag gaa Arg Leu Giu Gl~u ace ogo gaa gac Thr Arg Glu Asp oaa atc ggt goa Gin Ile Gly Ala ate gao gca cag Ile Asp Ala Gin oct qco gtt Pro Ala Val too att oca Ser Ile Pro 95 ggo att otg otg Gly Ile Leu Leu gga cag Gly Gin 100 ate get goa Ile Ala Ala got too ogo Ala Ser Arg 120 ogt caq otg ogt Arg Gin Leu Arg ote gga etc gat Leu Gly Leu Asp gte gca goa Val Ala Ala 115 gaa goa gta Glu Ala Val 403 451 499 ott gga cac too Leu Gly his Ser ggo att ttg ggo Gly Ile Leu Gly gtt Val1 130 gao aat Asp Asn 135 gaa gaa gao gtt Glu Giu Asp Val tta Leu 140 got tto gee ate. Ala Phe Ala Ile etg Leu 145 otg gge gea gea Leu Gly Ala Ala too cag tto got Ser Gin Phe Ala aag ggo gea oat Lys Gly Ala His atg Met 160 etc tot gtt ego Leu Ser Val Arg otg too ogt gag Leu Ser Arg Glu ato Ile 170 ato cag gao ac Ile Gin Asp Thr ate Ile 175 get ggt gte gat Ala Gly Val Asp ggg gta Gly Val 180 gag gte too otg ego aac got ogt goa eac ttt gtt gto tot ggt aag Glu Val Ser Leu Arg Asn Ala Arg Ala His Phe Val Val Ser Giy Lys cca gag gca Pro Glu Ala 200 etg aag aag get Leu Lys Lys Ala gct gct cta eag Ala Ala Leu Gin gca gct gat Ala Ala Asp gtt tac Val Tyr 215 aac gaa gac atc Asn Glu Asp Ile gaa aag cgc aag Glu Lys Arg Lys ggt Gly 225 gga tcc ctg gca Gly Ser Leu Ala cct aag ttt gac Pro Lys Phe Asp tac Tyr 235 ttg gat gtg gcc Leu Asp Val Ala cct ttc cac cac Pro Phe His His tcc atg cag gac Ser Met Gin Asp gcc gac ttg get Ala Asp Leu Ala gte Val1 255 gag tgg gea ac Glu Trp Ala Thr acc tgt Thr Cys 260 ggc eta aac Gly Leu Asn eca got gao Pro Ala Asp 280 gte Val1 265 aae gcg cgc gcg Asn Ala Arg Ala gca gaa gca att Ala Glu Ala Ile ota gtt aac Leu Val Asn 275 gat tac gtt Asp Tyr Val tgg gtt gag cag Trp Val Glu Gin goa aac etc aag Ala Asn Leu Lys got Al a 290 ott too Leu Ser 295 eto gat gea ggo Leu Asp Ala Gly ago egt tto aoo Ser Arg Phe Thr oca ttg eta gac Pro Leu Leu Asp ggt Gly 310 ogo gga ate tot Arg Gly Ile Ser ttg Leu 315 gtt cot geg tto Val Pro Ala Phe got goa gag ego Ala Ala Glu Arg 1027 1075 1123 aae ttg got 090 Asn Leu Ala Arg gge tte eac gtt Gly Phe His Val oct Pro 335 ace get gag gat Thr Ala Glu Asp tgg tee Trp, Ser 340 gag ttc get Giu Phe Ala etc ace ggg Leu Thr Gly 360 eca Pro 345 aag etg gtt aag Lys Leu Val Lys eca aao ggt gag Pro Asn Gly Glu cac aag gtt His Lys Val 355 gte otg got Val Leu Ala 1171 1219 tte toe ego etg Phe Ser Arg Leu ggt tat toe oca Gly Tyr Ser Pro ate Ile 370 ggc atg Gly Met 375 ace oca ace Thr Pro Thr ace Th r gee Ala 395 gat cot gag ate Asp Pro Glu Ile gca get gca gcg Ala Ala Ala Ala aae Asn 390 got gga cac tgg Ala Gly His Trp gaa atg goc ggt Glu Met Ala Giy gga eag tao tot Gly Gin Tyr Ser ga a Giu 405 1267 1315 1363 gaa gte ttc ace Glu Val Phe Thr aag Lys 410 aao aag gaa aag Asn Lys Giu Lys gtt tee etg etc Val Ser Leu Leu aag gtt Lys Val 420 gga ego tee Gly Arg Ser cag ttc aac too Gin Phe Asn Ser ttc tte gao ego Phe Phe Asp Arg tao atg tgg Tyr Met Trp 435 1411 aac ctg cag Asn Leu Gin 440 ttc ggt gca cag Phe Gly Ala Gin atc gtt tcc aag Ile Val Ser Lys cgt gca 8cc Arg Ala Thr 1459 ggt acc Giy Thr 455 tcc atc aac ggt Ser Ile Asn Gly gt t Val1 460 gtt gtc tcc gct Val Val Ser Ala atc cca gag gtt Ile Pro Glu Val gaa gca act gag Giu Ala Thr Glu atc aac gat ctg Ile Asn Asp Leu aac As n 480 gct gat ggc ttc Ala Asp Gly Phe 1507 1555 1603 tac gtt gca ttc Tyr Vai Ala Phe cca ggc acc gtg Pro Gly Thr Val cag atc cgc gca Gin Ile Arg Ala 8CC ctg Thr Leu 500 aag att gct Lys Ile Ala gac gga cac Asp Giy His 520 gat Asp 505 gca aac cca gag Ala Asn Pro Giu 8CC Thr 510 aag atc atc atc Lys Ile Ile Ile cag atc gag Gin Ile Giu 515 gac gat Ctg Asp Asp Leu 1651 1699 gct ggt ggc cac Ala Gly Gly His tcc tgg gtc aac Ser Trp Val Asn ctc ctg Leu Leu 535 8CC acc tac gca Thr Thr Tyr Aia gag Giu 540 ctg cgt tcc cgc Leu Arq Ser Arg aac gtt gtc gtc Asn Val Val Val 1747 atc ggt gqc ggc Ile Gly Gly Gly atc gga 8CC cct qca aag gct gct tac tac ctg Ile Gly Thr Pro Ala Lys Ala Ala Tyr Tyr Leu 555 560 565 1795 acc ggt gaa tgg Thr Gly Giu Trp acc gat ttg ggc Thr Asp Leu Gly cca gca atg cca Pro Ala Met Pro gtg gac Val Asp 580 1843 ggc atc ctc Gly Ile Leu tct cet cag Ser Pro Gin 600 gtg Val1 585 ggt 8CC gct. gcc Gly Thr Ala Ala atg Met 590 gca acc aag gaa Ala Thr Lys Giu gca acc act Ala Thr Thr 595 gtt gat cca Val Asp Pro 1891 1939 gtc aag cag gca Val Lys Gin Ala gtc gac acc cca Val Asp Thr Pro qgt Gly 610 cac gac His Asp 615 gct ggc ggc tgg Ala Gly Gly Trp gt t Val1 620 ggc cgt ggc gat Gly Arg Gly Asp cgt ggt ggc gtg Arg Gly Gly Val acc Thr 630 tct ggt ctg tca Ser Gly Leu Ser ctg cac gct gac Leu His Ala Asp a tg Met 640 tac gag ctg gac Tyr Giu Leu Asp aac Asn 645 1987 2035 2083 gat tct, gct gca Asp Ser Ala Ala tcc cgc ctq atc Ser Arg Leu Ile tcc atc gat tct Ser Ile Asp Ser gat gat Asp Asp 660 tac gca gat Tyr Ala Asp cac His 665 cgc gaa gag ctc Arg Giu Glu Leu atc Ile 670 gag gct atc aac Giu Ala Ile Asn aag acc gct Lys Thr Aia 675 2131 aag cct ttc Lys Pro Phe 680 ttc ggc gag gtc Phe Gly Giu Val gaa gag atg act tac Glu Glu Met Thr Tyr 685 gag tgg atc Glu Trp Ile 2179 cag cgt Gin Arg 695 tgg gtt gag ctt Trp Val Giu Leu tac cca act cag Tyr Pro Thr Gin ga c Asp 705 cca acc tgg gat Pro Thr Trp Asp gat Asp 710 cgt ttc ctc gat Arg Phe Leu Asp gtt cac cgc att Val His Arg Ile gct cgt ctc aac Ala Arg Leu Asn 2227 2275 2323 gca gag cac ggc Ala Giu His Gly gcc Al a 730 atc acc aca ctg Ile Thr Thr Leu ttc Phe 735 cca gac cat gcg Pro Asp His Ala tct gtg Ser Val 740 gaa aat gag Giu Asn Giu gag gcc gtc gaa Giu Ala Val Giu ctt ctt gct gct Leu Leu Ala Ala tac ccg cag Tyr Pro Gin 755 ttt att ggt Phe Ile Gly 2371 gcc cgc gag atc cag gtc tct gcg Ala Arg Giu Ile Gin Val Ser Ala 760 765 cgc gac gcc gcg Arq Asp Ala Ala ctg tgc Leu Cys 775 cgc aag cac cac Arg Lys His His cct atq cct tgg Pro Met Pro Trp cca gca atc gat Pro Ala Ile Asp 2419 2467 2515 2563 gct Ala 790 gac cta gca cgc Asp Leu Ala Arg tgg ggc ctt gac Trp Gly Leu Asp ctg tgg cag tcc Leu Trp Gin Ser aac gag cgc tac Asn Giu Arg Tyr ggc Sly 810 gcg aac tca gtc Ala Asn Ser Val cgc Arg 815 gtt atc cca gga Val Ile Pro Sly cca gtc Pro Val 820 tcc gtc gcc Ser Val Ala ggc cgc ttc Gly Arg Phe 840 ggc Sly 825 atc gac cgt gtt Ile Asp Arg Val gag cca gtt gca Slu Pro Val Ala gag ctg ctc Slu Leu Leu 835 2611 gaa gct gcc tgc Glu Ala Ala Cys gtt gac gct ctc gac ggc gag cca gaa Val Asp Ala Leu Asp Sly Giu Pro Giu 845 850 2659 gag atc Glu Ile 855 ttc gct cgc ctc Phe Ala Arg Leu aat Asn 860 gag tcc aag aac Glu Ser Lys Asn gag Giu 865 cgc gaa ttc ctg Arg Giu Phe Leu ct g Leu 870 gct acc cca cac Ala Thr Pro His gtg tgg cac ggc Val Trp His Gly aac As n 880 ctg atc gac aac Leu Ile Asp Asn 2707 2755 2803 gct cac gtc ctc Ala His Val Leu aac As n 890 gag ggt gct ttc Slu Sly Ala Phe gag Glu 895 ctc atc gag gag Leu Ile Glu Glu gat ggc Asp Sly 900 tac tgg gtc Tyr Trp Val cyt atc ctg gct Arg Ile Leu Ala tcc tac ttc gac Ser Tyr Phe Asp gat ctg cca Asp Leu Pro 915 2851 gtt gag cag cgc cca tac ctg gtt cag cat gtt gac atc cca gtt gag 29 2899 Val Glu Gin Arg Pro Tyr Leu Val Gln'His Val Asp Ile Pro Val Glu 920 925 930 ctg ggt gac gct ggt tgaaccggtg gtttcccaat tgg 2937 Leu Gly Asp Ala Gly 935 <210> 172 <211> 938 <212> PRT <213> Corynebacterium glutamicum <400> 172 Val Ser Ile Ser Ser Leu Thr Pro Leu His Ser Phe Lys Glu Pro Ala 1 5 10 Ile Leu Tyr Ala Gly Gin Ala Ser Ala Trp Gin Gin Val Ile Ala Asp 25 Ser Ser Glu Asp His Ile Thr Ala Thr His Leu Arg Glu Leu Leu Ser 40 Arg Ser Arg Ala Lys Thr Ala Pro Phe Ala Arg Gin Ile Thr Ala Ile 55 Val Pro Gly Ser Leu Ala Arg Leu Glu Glu Leu Thr Arg Glu Asp Ala 70 75 Gin Ile Gly Ala Asp Ile Asp Ala Gin Pro Ala Val Ser Ile Pro Gly 90 Ile Leu Leu Gly Gln Ile Ala Ala Thr Arg Gin Leu Arg Asp Leu Gly 100 105 110 Leu Asp Val Ala Ala Ala Ser Arg Leu Gly His Ser Gin Gly Ile Leu 115 120 125 Gly Val Glu Ala Val Asp Asn Glu Glu Asp Val Leu Ala Phe Ala Ile 130 135 140 Leu Leu Gly Ala Ala Ala Ser Gin Phe Ala Gly Lys Gly Ala His Met 145 150 155 160 Leu Ser Val Arg Gly Leu Ser Arg Glu Ile Ile Gin Asp Thr Ile Ala 165 170 175 Gly Val Asp Gly Val Glu Val Ser Leu Arg Asn Ala Arg Ala His Phe 180 185 190 Val Val Ser Gly Lys Pro Glu Ala Leu Lys Lys Ala Ala Ala Ala Leu 195 200 205 Gin Arg Ala Ala Asp Val Tyr Asn Glu Asp Ile Asn Glu Lys Arg Lys 210 215 220 Gly Gly Ser Leu Ala Glu Pro Lys Phe Asp Tyr Leu Asp Val Ala Ile 225 230 235 240 Pro Phe His His Ser Ser Met Gin Asp Ala Ala Asp Leu Ala Val Glu 245 250 255 Trp Ala Thr Thr Cys Gly Leu Asn Val Asn Ala Arg Ala Leu Ala Glu 260 265 270 Al a Lys Ala 305 Al a Al a Gly Pro ValI 385 Gly Ser Asp Lys Gly 465 Al a Ile Ile As n Lys 545 Al a Ile Ala 290 Pro Ala Glu Glu Ile 370 Ala Gln Leu Arg Ala 450 Ile Asp Arg Ile Le u 530 Asn Ala Le u 275 Asp Le u Glu Asp His 355 Val1 Al a T yr Le u Tyr 435 Arg Pro Gly Al a Gin 515 Asp Val1 Tyr As n Val1 Asp Asp 325 Ser Val1 Al a Ala Glu 405 Val1 Trp Thr Val Pro 485 Le u Glu Le u Val1 Le u 565 Pro Leu Gly 310 Asn Glu Leu Gly As n 390 Glu Gly Asn Gly Glu 470 T yr Lys Asp Leu Met 550 Thr Ala Ser 295 Arg Leu Phe Thr Met 375 Ala Val Arg Leu Thr 455 Glu Val1 Ile Gly Leu 535 Ile Gly Trp Asp I le Arg Pro 345 Phe Pro His Thr Ala 425 Phe Ile Thr Phe Asp 505 Ala Thr Gly Trp Val1 Ala Ser Pro 330 Lys Ser Thr Trp Lys 410 Gin Gly Asn Glu Lys 490 Ala Gly Tyr Gly S er 570 Glu Gly Leu 315 Gly Le u Arg Thr Al a 395 As n Phe Al a Gl y Leu 475 Pro As n Gly Ala Ile 555 Thr Gin Val 300 ValI Phe Val1 Leu Val 380 Glu Lys Asn Gln Val1 460 Ile Gly Pro His Glu 540 Gi y Asp Ile 285 Ser Pro His Lys Thr 365 Asp Met Giu Ser Arg 445 Val1 As n Thr Glu His 525 Leu Thr Leu Ala Arg Ala Val1 Leu 350 Gly Pro Ala Lys Met 430 Ile Val1 Asp Val1 Thr 510 Se r Arg Pro Gly As n Phe Phe Pro 335 Pro Tyr Glu Gi y Leu 415 Phe Val1 Ser Le u Asp 495 Lys Trp Se r Ala Phe 575 Leu Thr Se r 320 Thr As n Ser Ile Gly 400 Val1 Ph e Ser Ala As n 480 Gin Ile Val1 Arg Lys 560 Pro Ala Met Pro Val Asp Gly lie Leu Val Gly Thr Ala Ala Met Ala Thr 580 585 590 Lys Glu Ala Thr Thr Ser Pro Gin Val Lys Gin Ala Leu Val Asp Thr 595 600 605 Pro Gly Val Asp Pro His Asp Ala Gly Gly Trp Val Gly Arg Gly Asp 610 615 620 Ala Arg Gly Gly Val Thr Ser Gly Leu Ser His Leu His Ala Asp Met 625 630 635 640 Tyr Glu Leu Asp Asn Asp Ser Ala Ala Ala Ser Arg Leu Ile Ser Ser 645 650 655 Ile Asp Ser Asp Asp Tyr Ala Asp His Arg Glu Glu Leu Ile Glu Ala 660 665 670 Ile Asn Lys Thr Ala Lys Pro Phe Phe Gly Glu Val Glu Glu Met Thr 675 680 685 Tyr Ala Glu Trp Ile Gin Arg Trp Val Glu Leu Ala Tyr Pro Thr Gin 690 695 700 Asp Pro Thr Trp Asp Asp Arg Phe Leu Asp Leu Val His Arg Ile Glu 705 710 715 720 Ala Arg Leu Asn Glu Ala Glu His Gly Ala Ile Thr Thr Leu Phe Pro 725 730 735 Asp His Ala Ser Val Glu Asn Glu Glu Glu Ala Val Glu Lys Leu Leu 740 745 750 Ala Ala Tyr Pro Gin Ala Arg Glu Ile Gin Val Ser Ala Arg Asp Ala 755 760 765 Ala Trp Phe Ile Gly Leu Cys Arg Lys His His Lys Pro Met Pro Trp 770 775 780 Val Pro Ala Ile Asp Ala Asp Leu Ala Arg Trp Trp Gly Leu Asp Thr 785 790 795 800 Leu Trp Gin Ser Gin Asn Glu Arg Tyr Gly Ala Asn Ser Val Arg Val 805 810 815 Ile Pro Gly Pro Val Ser Val Ala Gly Ile Asp Arg Val Asp Glu Pro 820 825 830 Val Ala Glu Leu Leu Gly Arg Phe Glu Ala Ala Cys Val Asp Ala Leu 835 840 845 Asp Gly Glu Pro Glu Glu Ile Phe Ala Arg Leu Asn Glu Ser Lys Asn 850 855 860 Glu Arg Glu Phe Leu Leu Ala Thr Pro His Ile Val Trp His Gly Asn 865 870 875 880 Leu Ile Asp Asn Pro Ala His Val Leu Asn Glu Gly Ala Phe Glu Leu 885 890 895 Ile Glu Glu Asp Gly Tyr Trp Val Ile Arg Ile Leu Ala Asp Ser Tyr 284 905 910 Phe Asp Asp Leu Pro Val Glu Gin Arg 915 920 Pro Tyr Leu Val Gin His Val 925 Asp Ile Pro Val Giu Leu Gly Asp Ala Gly 930 935 <210> <211> <212> <213> <220> <c221> <222> <223> 173 921 DNA Corynebacterium glutamicum CDS (898) RX N01090 <400> 173 gccggtttgg gctggttgga gotctagatc gtaagtggtg togtacocat gacgtaccat taaccacgaa cgttttaaag aagccacgaa ggagcctgac atg gog tta oca cta Met Ala Leu Pro Leu ccc ago aag agc Pro Ser Lys Ser cga gca ott gtt Arg Ala Leu Val act Thr ggg gca agc caa Gly Ala Ser Gin ggo att Gly Ile ggc oto gc Gly Leu Ala ttg gtt got Leu Val Ala goc aaa gat ttg Ala Lys Asp Leu ogg tat ggg cac Arg Tyr Giy His aao ctc att Asn Leu Ile gca gat cta Ala Asp Leu cgo cgc gag gat Arg Arg Giu Asp gto ValI 45 oto aaa gag ato Leu Lys Giu Ile gc Ala gag aag Glu Lys aag cac gyc gtg Lys His Gly Val gtt gag gtc c90 Val Giu Val Arg gtg gat ttg agt Val Asp Leu Ser qa t Asp gag cca 900 cgc Glu Pro Ala Arg aag Lys 75 gtg ttg ato gat Val Leu Ile Asp gag Giu 80 ato aag aca agg Ile Lys Thr Arg gaa Giu 307 355 403 ato aac atc ato Ile Asn Ile Ile aao tot got ggc Asn Ser Ala Gly ato Ile goa ago ttt ggg Ala Ser Phe Gly cog ttc Pro Phe 100 aag gac cag Lys Asp Gin aca goc gtt Thr Ala Val 120 tgg tot tat gag Trp Ser Tyr Giu goc oag tto tca Ala Gin Phe Ser ott aat gc Leu Asn Ala 115 atg att gao Met Ile Asp ttt gag oto ac Phe Giu Leu Thr cac His 125 909 gtg ttg qgt Ala Val Leu Gly ggo Gi y 130 ogt ggo Arg Gly 135 aog ggo got att Thr Gly Ala Ile aat gtg gga tot Asn Val Gly Ser gog Ala 145 got ggc aat gtg Ala Gly Asn Val cca atc ccc aac aac gcc acg tat gtg ctc acc aag gct ggc gtg aac 595 Pro Ile Pro Asn Asn Ala Thr Tyr Val Leu Thr Lys Ala Gly Val Asn 150 155 160 165 gcg ttc acc gag gca atg cat tat gag ctg cgc gga act ggt gtg gcg 643 Ala Phe Thr Glu Ala Met His Tyr Glu Leu Arg Gly Thr Gly Val Ala 170 175 180 tgt act ttg ctc gca ccg gga cct gtc cgt gag gcg gag atc cct gag 691 Cys Thr Leu Leu Ala Pro Gly Pro Val Arg Glu Ala Glu Ile Pro Glu 185 190 195 tct gag aag tcg atc gtg gac aag gtt gtc cct gat ttc ttg tgg acc 739 Ser Glu Lys Ser Ile Val Asp Lys Val Val Pro Asp Phe Leu Trp Thr 200 205 210 acc tat gag tcc tgc tcc gca gag acc ttg cgt gcg ctg tct aag aat 787 Thr Tyr Glu Ser Cys Ser Ala Glu Thr Leu Arg Ala Leu Ser Lys Asn 215 220 225 cag cgt cgc gtt gtt cca ggt ccg ctg tcc aag gcc atg aat ttt gtg 835 Gin Arg Arg Val Val Pro Gly Pro Leu Ser Lys Ala Met Asn Phe Val 230 235 240 245 tcc tct gtt gct cca acc gct gtg ctc tcc cct gtt atg ggc tgg gtt 883 Ser Ser Val Ala Pro Thr Ala Val Leu Ser Pro Val Met Gly Trp Val 250 255 260 tat aag aag atg ggt tagtttttaa aagtgtctga atc 921 Tyr Lys Lys Met Gly 265 <210> 174 <211> 266 <212> PRT <213> Corynebacterium glutamicum <400> 174 Met Ala Leu Pro Leu Pro Ser Lys Ser Ala Arg Ala Leu Val Thr Gly 1 5 10 Ala Ser Gln Gly Ile Gly Leu Ala Ile Ala Lys Asp Leu Ala Arg Tyr 25 Gly His Asn Leu Ile Leu Val Ala Arg Arg Glu Asp Val Leu Lys Glu 40 Ile Ala Ala Asp Leu Glu Lys Lys His Gly Val Ile Val Glu Val Arg 55 Pro Val Asp Leu Ser Asp Glu Pro Ala Arg Lys Val Leu Ile Asp Glu 70 75 Ile Lys Thr Arg Glu Ile Asn Ile Ile Ile Asn Ser Ala Gly Ile Ala 90 Ser Phe Gly Pro Phe Lys Asp Gin Asp Trp Ser Tyr Glu Thr Ala Gin 100 105 110 286 Phe Gly Al a 145 Lys Gi y Ala Asp Al a 225 Al a Val1 Le u 115 Met Gi y Gl y Gi y Ile 195 Le u Ser Asn Gly As n Ile As n ValI Val1 180 Pro Trp Lys Phe Trp 260 Thr Arg Pro 150 Ala Cys Ser Thr Gin 230 Ser Tyr Al a Gly 135 Ile Phe Thr Giu Tyr 215 Arg Ser Lys Val1 120 Thr Pro Thr Leu Lys 200" Giu Arg Val Lys Thr Cys 140 Thr His Gly Asp Ala 220 Gly Ala Al a Val1 Val1 Giu Val1 190 Val1 Thr Leu Leu Leu Se r Thr 160 Arg GI u Pro Arg Lys 240 Pro <210> 175 <211> 1293 <212> DNA <213> Corynebacterium giutamicun <2 <221> CDS <222> (101)..(1270) <223> RXN02062 <400> 175 ttgtctaaac atcgttttgg ggtccgaatg tcgctgcgca actgttttta gatggctaat atagcccctt ctttgaaatt aga Arg ga a Gi u atg Met cct gag Giu t tg Leu ggt Gly gc tat Tyr acc Thr qca Ala ttg cca Pro cqa Arg cct Pro gaa gt t Val1 cgt Arg 30 atg Met aac tac Tyr 15 gag .Glu gag Giu cct ttaatgcccc catttcggta atg aga gtc gga atg Met Arg Vai Giy Met 1 ggc gct ggc gtg cac Giy Ala Gly Val His gct gaa gtt gat gtt Ala Giu Val Asp Val gtt ttc gtc cac ggc Val Phe Val His Gly att aag aca ctg tcc 115 163 211 259 307 Val Asp Pro Ala Leu Glu Ala Asn Pro Ala Ile Lys Thr Leu Ser ggt tta cgc atg Gly Leu Arg Met gaa got gca aac Glu Ala Ala Asn aac Asn gtg gat gtc gtg Val Asp Val Val 355 403 tca cac act tgg Ser His Thr Trp tat Tyr gca ggt ctt ggc Ala Gly Leu Gly cac ctt gca gct His Leu Ala Ala cgt ctc Arg Leu 100 cac ggc att Oct His Gly Ile Pro .105 cca tgg aag cgt Pro Trp Lys Arg 120 cac gtg got aco His Val Ala Thr cac tot ttg gag His Ser Leu Giu cca gat cgc Pro Asp Arg 115 tcc tcc tgg Ser Ser Trp 451 499 gag cag ctt Giu Gln Leu ggc Gly 125 ggt gga tao gao Gly Gly Tyr Asp gtg Val1 130 tot gaa Ser Glu 135 aaa aat goc atg Lys Asn Ala Met tao got gac gcg Tyr Ala Asp Ala atc gct gtg tcg Ile Ala Val Ser got Ala 150 cgo atg aaa gat Arg Met Lys Asp ato ctc got gog Ile Leu Ala Ala tao Tyr 160 oot 090 ato gag Pro Arg Ile Glu 547 595 643 gao aac gtg ogt Asp Asn Val Arg gtt Val1 170 gtc cto aac ggc Val Leu Asn Gly gao act gag ttg Asp Thr Giu Leu tgg oag Trp Gin 180 cot cgc 009 Pro Arg Pro ggo gtt gao Gly Val Asp 200 090 caa aaa Arg Gin Lys 215 tto qat gao gcg Phe Asp Asp Ala gat too gta ctc Asp Ser Val Leu ogo too ota Arg Ser Leu 195 ogo ato aco Arg Ile Thr oca cag ogg 000 Pro Gin Arg Pro ato Ile 205 gto gca ttt gto Val Ala Phe Val ggo Gly 210 ggc gto gag Gly Val Giu oto ato aag gca Leu Ile Lys Ala gca Ala 225 gog ott tto gao Ala Leu Phe Asp gag Glu 230 too gtg cag ott Ser Vai Gin Leu oto tgt 900 ggc Leu Cys Ala Gly oca gac aco 000 Pro Asp Thr Pro atc goa got ogo Ile Ala Ala Arg aco Thr 250 aoo goo otg gtg Thr Aia Leu Val gaa Glu 255 gaa oto oag gca Giu Leu Gin Ala aag 090 Lys Arg 260 gaa ggo att Giu Gly Ile gag att oto Giu Ile Leu 280 tgg gtt cay gao Trp Val Gin Asp atg Met 270 otg ggc aag gao Leu Gly Lys Asp aaa ato oaa Lys Ile Gin 275 att tao gag Ile Tyr Giu aco got gct gao Thr Ala Ala Asp aco Thr 285 ttc gtg tgc oca Phe Val Cys Pro coa otg 990 ato gtg aac ttg gaa gca atg goc tgc aac aoo gca gtt Pro Leu Gly Ile Val Asn Leu Giu Ala Met Ala Cys Asn Thr Ala Val 1027 295 300 gca tcc gee gtt gga. ggc atc Ala Ser Asp Val. Gly Gly Ile 315 ggc gcc etc gtt cac tac gee Gly Ala Leu Val His Tyr Asp 330 cgc gat atc gcc gaa gcg gtg aat Arg Asp Ile Ala Glu Ala Val Asn 345 gca gec aaa ttt ggt etc gca ggg Ala Ala Lys Phe Gly Leu Ala Giy 360 365 tcc tgg gca acg att gct cag cag Ser Trp Ala Thr Ile Ala Gin Gin 375 380 atg taaaacegaa agccggggaa cct Met 390 <210> 176 <211> 390 <212> PRT <213> Corynebacterium giutamicun cct Pro ga a Gi U ~aaa Lys 350 :gc krg 5cc ['hr gag Glu eat As n 335 etg Met gaa Giu att Ile 305 gt t Val1 gte Vali gct Aila gct Al a gtg Val1 385 gte Val gee Giu get Asp etc Ile 370 tac Tyr gee ggc Asp Gly ace tte Thr Phe 340 ega gag Arg Giu 355 aat get Asn Asp aaa tee Lys Ser cc Thr 325 gag Giu cc Thr ttc Phe ttg Leu 1075 1123 1171 1219 1267 1293 <400> 176 Met Arg Val Gly Met Met Thr Arg Giu 1 Gly Al a Val1 Ile Val1 Leu Leu Asp ValI Ale Giu Phe Lys Asp Al a Gi u Val1 130 Ile Gly Val1 Val1 Thr Val1 Al a Pro 115 Se r Al a ValI Asp His Leu Val Arg 100 Asp Ser Val 5 His Val1 Gly Ser His Le u Arg Trp Ser Val1 His Val1 Thr Ser His. Pro Se r Ala Thr C ys Asp 55 Gly His Gly Trp Giu 135 Arg Le u 25 Gi y Ale Arg Trp Pro 105 Arg As n Lys Tyr 10 Thr Ala Leu Met Tyr 90 His Glu Al a Asp Pro Phe Arg Ser Glu dly Al a Leu Giu 140 Ile Val1 Arg Met Asn Ala Gi y Al a 110 Gly Ale Al a T yr Glu Giu Pro Asn Gly His Gly Asp Ala 150 155 Pro Arg I Thr Glu L Val. Leu A 1 Val Gly A 210 Ala Ala L 225 Pro Asp T Leu Gin A Lys Asp L 2 Pro Ser I 290 Cys Asn T 305 Val Val A Val Giu T Ala Asp A 3 Ala Ile A 370 Vai Tyr L 385 <210> 177 le Glu Pro Asp Asn Val eu rg 95 rg eu hr ia ys 75 le hr sp hr rg 55 sn ys 165 Gin Leu Thr Asp Glu 245 Arg Gin Glu Val1 Thr 325 Glu Thr Phe Leu Pro Gly Arg Giu 230 Ile Glu Glu Pro Val1 310 Thr Arg Al a Ser Met 390 Arg Vai Gin 215 Ser Ala Giy le Leu 295 Ala Gly Asp Ala Trp 375 Pro Asp 200 Lys Val1 Al a Ile Leu 280 Gly Se r Ala Ile Lys 360 Al a ValI 170 Phe Gin Val1 Le u Thr 250 T rp Al a Val Val1 Val1 330 Giu Gly Ile Val1 Asp Arg Giu ValI 235 Thr Val1 Ala As n G ly 315 His Ala Leu Al a Le u Asp Pro His 220 be u Ala Gin Asp Leu 300 Gly T yr Val1 Al a Gin 380 As n Al a Ile 205 be u Cys be u Asp Thr 285 Gi u Ile Asp As n Gly 365 Gin Giy Glu 190 Val Ile Ala Val1 Met 270 Phe Ala Pro Giu Lys 350 Arg Thr Ile 175 Asp Ala Lys Gly Giu 255 Leu Val Met Glu As n 335 Met Glu Ile 160 Asp Ser Phe Al a Ala 240 Giu Gi y Cys Ala Val1 320 Asp Val1 Arg Asp <211> 1266 <212> DNA <213> Corynebacterium glutamicun <220> <221> CDS <222> (1243) <223> RXN02148 <400> 177 gcctcaqact acggaatccc tgtgcaggtg gtatctgttg attcagcacc gttttatggt gcgcgtcgct actaagaaat agttcgtcag gagaatcttt gtg tct gca tcc cga Val Ser Ala Ser Arg aaa act ctc gtt Lys Thr Leu Val gtg Val1 acc: aat gat ttt Thr Asn Asp Phe cca cgg atc: ggc Pro Arg Ile Gly gga atc Gly Ile caa agc tat Gin Ser Tyr gtg gtg ttt Val Val Phe agg gat ttc atc Arg Asp Phe Ile act caa gat cct Thr Gin Asp Pro gag tcg atc Giu Ser Ile gcc tac gac Ala Tyr Asp 211 259 gcg tcg act caa Ala Ser Thr Gin aac As n gct gag gaa gcg Ala Giu Glu Ala aag act Lys Thr ttg gac tat gag Leu Asp Tyr Giu att agg tgg cct Ile Arg Trp Pro tcg gtg atg ctg Ser Val met Leu acc cca aca acg Thr Pro Thr Thr gca Al a cac gct atg qcq His Ala Met Ala gag Glu atc att cgt gag Ile Ile Arg Glu gag atc gat aat Glu Ile Asp Asn tgg ttc ggt gct Trp Phe Gly Ala gct ccg ttg gcg Ala Pro Leu Ala ttg atg Leu Met 100 gca ggc aca Ala Gly Thr cat ggg cat His Gly His 120 aag cag gca ggt Lys Gin Ala Gly agc aag gtt att Ser Lys Val Ile gcc tcc act Ala Ser Thr 115 aga caa tcg Arg Gin Ser gag gtg ggg tgg Glu Val Gly Trp atg ctt cct gga Met Leu Pro Gly ttg cgc Leu Arg 135 aaa atc ggc act Lys Ile Giy Thr gag Giu 140 qtg gac gtg ctg Val Asp Val Leu tat atc tcg cag Tyr Ile Ser Gin acg ctg cgc aga Thr Leu Arg Arg aaa agt gct ttt Lys Ser Ala Phe gga Gi y 160 tcg cac: ccg act Ser His Pro Thr ttt Phe 165 gaa cat ttg cct Giu His Leu Pro t cc Ser 170 ggc gtg gac gtt Gly Val Asp Val aag Lys 175 aga ttc act ccg Arg Phe Thr Pro gcc acg Ala Thr 180 cca gag gac Pro Giu Asp acc ccg gtt Thr Pro Val 200 agc gca aca agg Ser Ala Thr Arg aag cta gga ttc Lys Leu Gly Phe acg gac acc Thr Asp Thr 195 aaa ggc cag Lys Gly Gin 691 739 att gcc tgt aac Ile Ala Cys Asn cgt tta gtg ccg Arg Leu Val Pro agg Arg 210 gac tcg Asp Ser 215 ctg atc aag gcg Leu Ile Lys Ala atg Met 220 cca cag gtg att Pro Gin Val Ile gcg cgc cca gat Ala Arg Pro Asp gcg cag ttg ctc att gtg ggc agt ggg cga tac gag tcg act ttg cgg Ala Gin Leu Leu Ile Val Giy Ser Giy Arg Tyr Glu Ser Thr Leu Arg 230 235 cgc ctt gce act gac gtg age cag aac Arg Leu Ala Thr Asp Val Ser Gin Asn 250 gaa tat caa gat atg atc aac aeg ctt Giu Tyr Gin Asp Met Ile Asn Thr Leu 265 270 atg cca geg cgc acc cgc ggt ggc gga Met Pro Ala Arg Thr Arq Giy Gly Gly 280 285 att gte tat etc gag gca caa gee tgc Ile Val Tyr Leu Giu Ala Gin Ala Cys 295 300 ace tet ggc gge gcg cca gag aeg gtg Thr Ser Gly Giy Ala Pro Giu Thr Vai 310 315 gtg gag qgg tcg gac gte gat aag etg Val Glu Giy Ser Asp Val Asp Lys Leu 330 ctc gac gat ceg ate egc ege gee gcg Leu Asp Asp Pro Ile Arg Arg Ala Ala 345 350 cat gtg gag gee gaa tgg tog tgg gaa His Val Glu Ala Glu Trp Ser Trp Giu 360 365 aat att ttg cag agt gaa eca ega tgal Asn Ile Leu Gin Ser Giu Pro Arg 375 380 <210> 178 <211> 381 <212> PRT <213> Corynebaeterium giutamieum <400> 178 Val Ser Ala Ser Arg Lys Thr Leu Val 1 5 Arg Ile Gly Gly Ile Gin Ser Tyr Leu 25 Asp Pro Giu Ser Ile Val Vai Phe Ala 40 Ala His Ala Tyr Asp Lys Thr Leu Asp 55 Arg Ser Val Met Leu Pro Thr Pro Thr 70 gtg Val1 255 gee Ala ott Le u gga Gly aet Thr t ct Ser 335 atg Met ate 240 aaa Lys gee Al a gat Asp gtg Val1 eeg Pro 320 gag Giu gge Gly atg tte Phe gca Ala gtt Val1 cog Pro 305 gea Al a ct t Le u get Ala ggg et t Le u ga t Asp gaa Glu 290 gt g Val1 act Thr tta Le u gca Al a gag Giu 370 ggg Gly at t Ile 275 ggo Gly ata Ile ggc Gly att Ile ggt Gly 355 egg Arg cgc Arg 260 ttc Phe ttg Le u gcc Ala ctg Leu gag Giu 340 agg Arg ttg Le u et t Le u gcg Al a ggC Gly gge Gly gt t Val1 325 ctt Leu gcg Ala acc Thr 883 931 979 1027 1075 1123 1171 1219 1266 Ile Met Gly tggttgg acagetgttg ata Val Thr Asn Asp Phe Pro 10 Arg Asp Phe Ile Ala Thr Ser Thr Gin Asn Ala Giu Tyr Giu Val Ile Arg Trp Thr Ala His Ala Met Ala Ile Ile Arg Glu Arg Glu Ile Asp Asn Val Trp Phe Gly Ala Ala Ala 90 Pro Leu Ala Leu Met Ala Gly Thr Ala Lys Gin Ala Gly Ala Ser Lys 100 105 110 Val Ile Ala Ser Thr His Gly His Giu Val Gly Trp Ser Met Leu Pro 115 120 125 Gly Ser Arg Gin Ser Leu Arg Lys Ile Gly Thr Glu Val Asp Val Leu 130 135 140 Thr Tyr Ile Ser Gin Tyr Thr Leu Arg Arg Phe Lys Ser Ala Phe Gly 145 150 155 160 Ser His Pro Thr Phe Giu His Leu Pro Ser Gly Val Asp Val Lys Arg 165 170 175 Phe Thr Pro Ala Thr Pro Giu Asp Lys Ser Ala Thr Arg Lys Lys Leu 180 185 190 Gly Phe Thr Asp Thr Thr Pro Val Ile Ala Cys Asn Ser Arg Leu Val 195 200 205 Pro Arg Lys Giy Gin Asp Ser Leu Ile Lys Ala Met Pro Gin Vai Ile 210 215 220 Ala Ala Arg Pro Asp Ala Gin Leu Leu Ile Val Gly Ser Gly Arq Tyr 225 230 235 240 Giu Ser Thr Leu Arg Arg Leu Ala Thr Asp Val Ser Gin Asn Val Lys 245 250 N255 Phe Leu Gly Arg Leu Giu Tyr Gin Asp Met Ile Asn Thr Leu Ala Aia 260 265 270 Ala Asp Ile Phe Ala Met Pro Ala Arg Thr Arg Gly Giy Gly Leu Asp 275 280 285 Val Giu Gly Leu Gly Ile Val Tyr Leu Giu Ala Gin Ala Cys Gly Vai 290 295 300 Pro Val Ile Ala Gly Thr Ser Gly Gly Ala Pro Giu Thr Val Thr Pro 305 310 315 320 Ala Thr Gly Leu Val Val Giu Gly Ser Asp Val Asp Lys Leu Ser Glu 325 330 335 Leu Leu Ile Giu Leu Leu Asp Asp Pro Ile Arq Arg Aia Ala Met Giy 340 345 350 Ala Ala Gly Arq Ala His Val Giu Ala Giu Trp Ser Trp Glu Ile Met 355 360 365 Gly Giu Arg Leu Thr Asn Ile Leu Gin Ser Giu Pro Arg 370 375 380 <210> 179 <211> 1287 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(1264) <223> RXN02595 <400> 179 gtgggtaaag gggactccga ggaagtccac gtcgtcttct ttcgcggatt tgtgcggggg agtqggtggg agagaaaacg ttcgcggcgc tgaggatggt gtg atc gtt gtg Val Ile Val Val 1 atg gct tcc att Met Ala Ser Ile atg Met gct tgt tta Ala Cys Leu aaa gca Lys Ala 15 gct aga ctg aat Ala Arg Leu Asn aac cct Asn Pro 163 211 atg aag atc Met Lys Ile ggc gga agt Gly Gly Ser ttg ttq tgc tgg Leu Leu Cys Trp cg t Arg gat acc act cat cct caa gqt Asp Thr Thr His Pro Gin Gly gaa cgc tat ctq Glu Arg Tyr Leu cgg gtg ggt Arg.Val Gly gag ttt Giu Phe ttg gcg gat Leu Ala Asp cag ggc Gin Giy cat gag gtg gtg His Glu Val Val cgt act gct ggg Arg Thr Ala Gly acg gat gcg cca Thr Asp Ala Pro cgg Arg cgt tct ttc cgc Arg Ser Phe Arg ggt gtg agg tat Gly Val Arg Tyr tcc Ser 80 agg agc ggt ggg Arg Ser Gly Giy aag Lys ttt agt gtg tat Phe Ser Val Tyr ccc Pro aag gcg tgg gtg Lys Ala Trp Val gcc Ala 95 atg atg ttg ggt Met Met Leu Gly cgt gtg Arg Val 100 ggg att ggc Gly Ile Gly ggc att ccg Giy Ile Pro 120 ttt tcc aag gtt Phe Ser Lys Val gtg gtg gtg gat Val Val Val Asp acg cag aat Thr Gin Asn 115 act gtg ttg Thr Val Leu ttt ttt gga aag Phe Phe Gly Lys ttt Phe 125 ttc tcc ggt aag Phe Ser Gly Lys ccg Pro 130 ctc acg Leu Thr 135 cat cat tgc cat His Hius Cys His gag cag tgg ccg Glu Gin Trp Pro gtg ggt cgg gtg Val Gly Arg Vai ctg Leu 150 gcg aag gtt ggt Ala Lys Val Giy ctg att gag agc Leu Ile Giu Ser atc gcg ccg cgc Ile Aia Pro Arg gct Al a 165 tac aaa act gcg Tyr Lys Thr Ala ccg Pro 170 tat gtg act gtt Tyr Val Thr Vai tca Ser 175 gag ccg agc gct Giu Pro Ser Ala gag gag Giu Giu 180 ctc att gcg Leu Ile Ala ttg Leu 185 ggt gtg gat cag Gly Val Asp Gin cgg att cat atc Arg Ile His Ile gtg cgc aat Val Arg Asn 195 ggc gtg gat Gly Val Asp 200 ccc gtg ccg ctg Pro Val Pro Leu cac His 205 acg ccq aag otg Thr Pro Lys Leu gat Asp 210 cgc gat ggc Arg Asp Gly cag cat Gin His 215 gcg qtg acg ttg Ala Vai Thr Leu t cg Ser 220 cgc ctg gtt ccg Arg Leu Val Pro aag cag att gag Lys Gin Ile Giu gog atg gat gtc Ala Met Asp Val gog gcg cto gac Ala Ala Leu Asp 9gc Gly 240 gtg gtg ctg gat Val Val Leu Asp gta Val1 245 gto gaa agc ggt Val Giu Ser Gly t gg T rp 250 tgg cag aag gaa Trp Gin Lys Giu ctg be u 255 gtc gat tat gcc Vai Asp Tyr Ala cgc acq Arg Thr 260 ctg ggt gtg Leu Gly Vai cac aag cac His Lys his 280 gat cqc gtg gtt Asp Arg Val Val cac ggc cag gto His Gly Gin Val gcc gag gat Ala Giu Asp 275 atg cot tog Met Pro Ser gcc ctg ttg gag Ala Leu Leu Giu gcc acg att cat Ala Thr Ile His ctc Leu 290 cyc aag Arq Lys 295 gaa ggo tgg ggc Giu Gly Trp Giy ctg Leu 300 gcg gtc aog gag Ala Val Thr Giu gcg gcg cag cac Ala Aia Gin His 305 ctg cgc gat tcc Leu Arg Asp Ser ggo Gly gtc Val1 325 ccg acg atc ggt Pro Thr Ile Gly cga agc toa ggc Arg Ser Ser Gly gtc gac ggc gaa Val Asp Gly Giu a cc Thr 330 ggC ctg ctt gto Gly Leu Leu Val too aag gcc gag Ser Lys Ala Giu ott att Leu Ile 340 1027 1075 1123 1171 1219 toa gco aco Ser Ala Thr ggo goc ago Gly Ala Ser 360 aaa Lys 345 aco ctg ott ato Thr Leu Leu Ile gao Asp 350 goc too oto ogc Ala Ser Leu Arg too aag oto Ser Lys Leu 355 gac aco gcg Asp Thr Ala gcg aag cag cgo Ala Lys Gin Arg gaa aac tac aag Giu Asn Tyr Lys gga gog Gly Ala 375 cag tto gag gaa Gin Phe Giu Giu ota Leu 380 ott ott ggt ott Leu Leu Gly Leu gog Ala 385 tog aaa aag Ser Lys Lys 1264 tagtoooago ggcaacgooa too <210> 180 <211> 388 <212> PRT <213> Gorynebacterium giutamicum <400> 180 Val Ile Vai Val Ala Met Ala Ser Ile Met 1 5 10 1287 Ala Cys Leu Lys Ala Ala Arg Thr Giu His Arg Met Val1 Lys Val1 145 Ile Pro His Leu His 225 Val1 Asp Gin His Ala 305 Leu Lys Asn Pro Leu Asp Gly Gly Thr 115 Thr Gly Pro Ala ValI 195 Arg Gin Leu Al a Ala 275 Met Gin Asp Glu Pro Gly Asp Pro Lys Val1 As n Leu Val1 Al a 165 Giu As n Gly Glu Val1 245 Thr Asp Ser Gi y Val1 325 Ile Met Gly Gin Arg 70 Phe Gi y Gi y Leu Leu 150 Tyr Leu Gly Gin His 230 Val1 Leu His Arg Val1 310 Val1 Se r Lys Giy Gly Arg Ser Ile Ile Thr 135 Ala Lys Ile Val1 His 215 Ala Glu Gly Lys Lys 295 Pro Asp Ala Ile Ser 40 His Ser Val1 Gly Pro 120 His Lys Thr Ala Asp 200 Ala Met Ser Val1 His 280 Giu Thr Gly Thr Le u Glu Giu Phe Tyr Thr 105 Phe His Val1 Ala Leu 185 Pro Val1 Asp Gly Ser 265 Ala Gly Ile Giu Lys Leu Arg Val1 Arg Pro 90 Phe Phe Cys Gi y Pro 170 Gly Val1 Thr Val Trp 250 Asp Leu Trp Gly Thr 330 Thr Leu Tyr Val1 Asp 75 Lys Ser Gly His Trp 155 Tyr Val1 Pro Leu Val1 235 T rp Arg Leu Gly Tyr 315 Gly Leu Cys Le u Phe Gly Al a Lys Lys Lys 140 Leu Val1 Asp Leou Ser 220 Ala Gin Val Giu Le u 300 Arg Leu Le u Trp Glu Arg Val1 Trp Vali Phe 125 Glu Ile Th r Gin His 205 Arg Al a Lys Val1 Arg 285 Al a Se r Le u Ile Arq Arg Thr Arg Val1 Asp 110 Ph e Gin Giu ValI Gin 190 Thr Leu Leu Glu Ph e 270 Al a Val Ser Val1 Asp Asp Val1 Al a Tyr Al a Val Se r T rp Ser Ser 175 Arg Pro Val1 Asp Leu 255 His Thr Thr Gly Asp 335 Al a Thr Gly Gi y Se r Met Val1 Gly Pro Gin 160 Glu Ile Lys Pro Gly 240 Val1 Gly Ile Glu Gly 320 Se r Se r Leu Arg Ser Lys Leu Gly Ala Ser Ala 355 360 Lys Gin Arg Giu Asn Tyr Lys Trp Asp Thr Ala Gly Ala Gln Phe Glu Glu Leu 370 375 380 Ala Ser Lys Lys 385 Leu Leu Gly Leu <210> 18). <211> 2334 <212> DNA <213> Corynebacterium glut amicum <220> <221> <222> <223> CDS (101) (2311) RXS 00148 <400> 181 ctttgagggc agcgcgcatg cgcccgatgg ttatttgaac atgacaattg atgccgcggc gacgctggct gacctgctag atgctttggg agcttaaatc atg acg tcg atc Met Thr Ser Ile 1 115 aat ttt tca gac Asn Phe Ser Asp atc cca Ile Pro ttg act gct Leu Thr Ala gag Glu 15 aca cgt gca tcg Thr Arg Ala Ser gag tca Glu Ser cac aac gtt His Asn Val gtc aag cgc Val Lys Arg gcc ggc aag gig Ala Giy Lys Val aac act ccc gaa Asn Thr Pro Glu ggc ait gat Gly Ile Asp caa gcg gcg Gin Ala Ala gta itc acg cag Val Phe Thr Gin gac cqc gac gag Asp Arg Asp Giu qcg Al a so gga cat Gly His ccg gtg gat tct Pro Val Asp Ser cca ggt caa aag Pro Gly Gln Lys cca Pro ttt aig cgc ggg Phe Met Arg Gly tac cca act atq Tyr Pro Thr Met tac Tyr acc aat cag ccg Thr Asn Gin Pro acg att cgc cag Thr Ile Arg Gin tac Tyr gca ggc itt tca Ala Gly Phe Ser gcc gcg gaa tcc Ala Ala Giu Ser aai Asn gcg ttt tat cgg Ala Phe Tyr Arg agg aac Arg Asn 100 cii gct gcg Leu Ala Ala cac cgc ggt His Arg Gly 120 ggt Gly 105 caa aaa ggt ttg Gln Lys Gly Leu gtt gcg tic gat Val Ala Phe Asp cta gcg acc Leu Ala Thr 115 gat gig ggi Asp Val Gly 451 499 tat gac tcg gat Tyr Asp Ser Asp gag cgc gtg gtc Giu Arg Vai Val atg gcc Met Ala 135 ggc qg gcg att Gly Val Ala Ile tcg att ttg gat Ser Ile Leu Asp atg Met 145 oqt cag ctg ttt Arg Gin Leu Phe ga t Asp 150 ggc att, gat ttg Gly Ile Asp Leu tcc Se r 155 ago gtg tog gtg Ser Val Ser Val atg acc atg aat Met Thr Met Asn 595 643 ~t gct gtg ctg ccg Ala Val Leu Pro ctt gcg ttc tat Leu Ala Phe Tyr gtg gcg got gag Val Ala Ala Giu gaa caa Giu Gin 180 qgt gtg ggt Giy Val Gly aaa gaa ttt Lys Glu Phe 200 ccg Pro 185 gag caq Ott gcg Giu Gin Leu Ala ggc Gly 190 acg ato cag aat Thr Ile Gin Asn gac atc ttg Asp Ile Leu 195 aag cog tog Lys Pro Ser atg gtg cgc aac Met Val Arg Asn tat att tat cog Tyr Ile Tyr Pro atg cgc Met Arg 215 ato att tcc aac Ile Ile Ser Asn ttt gag tao acc Phe Giu Tyr Thr tco Ser 225 ttg aag atg oca Leu Lys Met Pro og t Arg 230 ttt aac toc att Phe Asn Ser Ilie tog Ser 235 att tot ggc tat Ile Ser Giy Tyr cac His 240 ato cag gaa gog Ile Gin Glu Ala gog act gcc gat Ala Thr Ala Asp gag ctg gcc tao Glu Leu Ala Tyr otg gog gat ggt Leu Ala Asp Gly att gaa Ile Giu 260 tao ato ogt Tyr Ile Arg oct ogt otg Pro Arg Leu 280 gca Ala 265 ggt aaa gag gta Gly Lys Glu Val ggc Gly 270 ott gao gtg gat Leu Asp Val Asp aaq ttc gog Lys Phe Ala 275 ttc atg gag Phe Met Glu too tto ttc tg Ser Phe Phe Trp ggt GI y 285 att tot atg tao Ile Ser Met Tyr aco Thr 290 ato gca Ile Ala 295 aag otg cgt gog Lys Leu Arg Ala gga Gly 300 cga otg ctg tgg Arg Leu Leu Trp ago Ser 305 gag ttg gtg gca Glu Leu Val Ala aaa Lys 310 tto gat cog aaa Phe Asp Pro Lys goc aag too cag Ala Lys Ser Gin ctg ogo acg cac Leu Arg Thr His 1027 1075 1123 cag aoo tot ggt Gin Thr Ser Gly t gg Trp 330 tog ttg aco gog Ser Leu Thr Ala oag Gin 335 gat gtg tao aac Asp Val Tyr Asn aac gtc Asn Val 340 gcc cgc acO Ala Arg Thr tog ctg cac Ser Leu His 360 gcg Ala 345 att gag gog atg Ile Glu Ala Met gca aco cag ggo Ala Thr Gin Gly cac aco cag His Thr Gin 355 coo aco gat Pro Thr Asp aco aat gca Ott Thr Asn Ala Leu gag gog ttg gog Giu Ala Leu Ala otg Leu 370 1171 1219 1267 ttc tot got ogt ato goc cga aac acc cag otg ttg otg cag oag gaa Phe Ser 375 Ala Arg Ile Ala Asn Thr Gin Leu Leu Gin Gin Glu tct Ser 390 ggc aeg gtg cgt Giy Thr Val Arg cca Pro 395 gtt gat cca tgg Val Asp Pro Trp ggc tcc tat tac Gly Ser Tyr Tyr gtg Val1 405 1315 1363 gag tgg ttg acc Glu Trp Leu Thr gag ctg qct aac Giu Leu Ala Asn gcg cgc aag cac Ala Arg Lys His atc gat Ile Asp 420 gag gtg gag Glu Val Giu cct aag ctg Pro Lys Leu 440 gaa Giu 425 gcc ggc gga atg Ala Gly Gly Met gcg Ala 430 tag gcc acc gcg Gin Ala Thr Ala cag gga att Gin Gly Ile 435 gct cgc att Ala Arg Ile 1411 1459 cgc att gag gaa Arg Ile Giu Giu gcg gca cgc act Ala Ala Arg Thr cag Gin 450 gat ttt Asp Ser 455 ggc cgc tag gcg Gly Arg Gin Ala ttg Leu 460 atc ggc gtg aat Ile Gly Val Asn tac gtg gtg gaa Tyr Val Ala Glu gat gag gaa att Asp Glu Giu Ile gte ctc aag gtt Val Leu Lys Vai gac aac ace aag gtt Asp Asn Thr Lys Val 480' cgc Arg 485 1507 1555 1603 gca gaa tag ttg Ala Giu Gin Leu gct Al a 490 aaa ctc gcg caa Lys Leu Ala Gin ctq Leu 495 aaa gca gag cgc Lys Ala Glu Arq aac gat Asn Asp 500 geg gaa gtc Ala Giu Val gag cat aaa Giu His Lys 520 get geg cig gat Ala Ala Leu Asp ttg aea get gct Leu Thr Ala Ala gee cgc aae Ala Arg Asn 515 aaa ett gce Lys Leu Ala 1651 1699 gag cca ggq gat Giu Pro Gly Asp ttq Le u 525 gat cag aac etq Asp Gin Asn Leu t Le u 530 gtc gat Val Asp 535 gct gcg cgc gca Ala Ala Arg Ala gct act att gga Ala Thr Ile Giy atc tce gat gt Ile Ser Asp Ala ttg Leu 550 gaa gtt gtt ttt Giu Val Val Phe cgc tat gaa gta Arg His Glu Ala ato agg aog etg Ile Arg Thr Leu tct Se r 565 1747 1795 1843 ggc gtg tat aag Gly Val Tyr Lys ga t Asp 570 gag gtt gga aag Giu Val Gly Lys gaa Glu 575 ggt ata gtg agc Gly Thr Val Ser aac gtt Asn Val 580 gaa cgc qcg Giu Arg Ala tgc ezca tgt Arg Pro Arg 600 gco ctg gtt gao Ala Leu Ala Asp ttt gag gtt gag Phe Glu Ala Glu gaa ggt ogo Giu Gly Arg 595 cat gao tgt His Asp Arg 1891 1939 ato ttt att gte Ile Phe Ile Ala aag Lys 605 atg gge tag gat Met Gly Gin Asp gga Gly 610 gga tag aag gtt gte geg tot get tat get gac etg gge atg gac gtg Gly Gin Lys Val Val Ala Ser Ala Tyr Ala Asp Leu Gly Met Asp Val 1987 61.5 620 625 gat gtt gga ccg ctg ttt caa act cca gcc gaa gct gcc cgc gcc gcc 2035 Asp Val Gly Pro Leu Phe Gln Thr Pro Ala Glu Ala Ala Arg Ala Ala 630 635 640 645 gtg gac gcc gat gtt cac gtg gtg ggt atg tct tcg ctg gca gca ggc 2083 Val Asp Ala Asp Val His Val Val Gly Met Ser Ser Len Ala Ala Gly 650 655 660 cac ctc acc ttg ctg ccc gag ctg aag aaa gaa ctt gca gct ctt ggc 2131 His Leu Thr Len Leu Pro Giu Leu Lys Lys Glu Leu Ala Ala Leu Gly 665 670 675 cgc gat gac att ctg gtc acc gtg ggc ggc gtc att ccg ccg gqc gat 2179 Arg Asp Asp Ile Leu Val Thr Val Gly Gly Val Ile Pro Pro Gly Asp 680 685 690 ttc cag gat ctc tac gat atg ggt gcc gcc gcg att tac cct tca gga 2227 Phe Gin Asp Leu Tyr Asp Met Gly Ala Ala Ala Ile Tyr Pro Ser Gly 695 700 705 acc gtc atc gcg gag tcg gcg atc gat ctg atc acc cga ctc gcc gca 2275 Thr Val Ile Ala Glu Ser Ala Ile Asp Le Ile Thr Arg Leu Ala Ala 710 715 720 725 cac ctg ggc ttt gac ctg gat gtg gat gtg aat gaa tgatcacggt 2321 His Leu Giy Phe Asp Leu Asp Val Asp Val Asn Gin 730 735 ttcctagaag aca 2334 <210> 182 <211> 737 (212> PRT <213> Corynebacterium giutamicum <400> 182 Met Thr Ser Ile Pro Asn Phe Ser Asp Ile Pro Leu Thr Ala Giu Thr 1 5 10 Arg Ala Ser Gin Ser His Asn Val Asp Ala Gly Lys Val Trp Asn Thr 25 Pro Gin Gly Ile Asp Val Lys Arg Val Phe Thr Gin Ala Asp Arg Asp 40 Gin Ala Gin Ala Ala Gly His Pro Val Asp Ser Len Pro Gly Gin Lys 55 Pro Phe Met Arg Gly Pro Tyr Pro Thr Met Tyr Thr Asn Gin Pro Trp, 70 75 Thr Ile Arg Gin Tyr Ala Gly Phe Ser Thr Ala Ala Giu Ser Asn Ala 90 Phe Tyr Arg Arg Asn Len Ala Ala Gly Gin Lys Gly Leu Ser Val Ala 100 105 110 Phe Asp Leu Ala Thr His Arg Gly Tyr Asp Ser Asp Asn Gin Arg Val Val Met 145 Met Ala Gin Pro Ser 225 Ile Ala Val Tyr Ser 305 Leu Val Gin Ala Leu 385 Gly Arg Thr Gly 130 Arg Thr Al-a Asn Pro 210 Leu Gin Asp Asp Thr 290 Glu Arg Tyr Gly Leu 370 Leu Ser Lys Ala 115 Asp Gin Met Glu Asp 195 Lys Lys Glu Gly Lys 275 Phe Leu Thr Asn His 355 Pro Gin Tyr His Gin 435 Val Leu Asn Glu 180 Ile Pro Met Ala Ile 260 Phe Met Val His Asn 340 Thr Thr Gin Tyr Ile 420 Gly Gly Met Phe Asp 150 Gly Ala 165 Gin Gly Leu Lys Ser Met Pro Arg 230 Gly Ala 245 Glu Tyr Ala Pro Glu Ile Ala Lys 310 Ser Gin 325 Val Ala Gin Ser Asp Phe Glu Ser 390 Val Glu 405 Asp Glu Ile Pro 120 Ala Gly 135 Gly Ile Val Leu Val Gly Glu Phe 200 Arg Ile 215 Phe Asn Thr Ala Ile Arg Arg Leu 280 Ala Lys 295 Phe Asp Thr Ser Arg Thr Leu His 360 Ser Ala 375 Gly Thr Trp Leu Val Glu Lys Leu 440 Val Asp Pro Pro 185 Met Ile Ser Asp Ala 265 Ser Leu Pro Gly Ala 345 Thr Arg Val Thr Glu 425 Arg Ala Leu Ile 170 Glu Val Ser Ile Leu 250 Gly Phe Arg Lys Trp 330 Ile Asn Ile Arg Asn 410 Ala Ile Ile Asp 140 Ser Ser 155 Leu Ala Gin Leu Arg Asn Asn Ile 220 Ser Ile 235 Glu Leu Lys Glu Phe Trp Ala Gly 300 Asn Ala 315 Ser Leu Glu Ala Ala Leu Ala Arg 380 Pro Val 395 Glu Leu Gly Gly Glu Glu 125 Ser Val Phe Ala Thr 205 Phe Ser Ala Val Gly 285 Arg Lys Thr Met Asp 365 Asn Asp Ala Met Ser 445 Ile Ser Tyr Gly 190 Tyr Glu Gly Tyr Gly 270 Ile Leu Ser Ala Ala 350 Glu Thr Pro Asn Ala 430 Ala Leu Val Ile 175 Thr Ile Tyr Tyr Thr 255 Leu Ser Leu Gin Gin 335 Ala Ala Gin Trp Arg 415 Gin Ala Asp Ser 160 Val Ile Tyr Thr His 240 Leu Asp Met Trp Ser 320 Asp Thr Leu Leu Ala 400 Ala Ala Arg Thr Gin Ala Arg Ile Asp Ser Gly Arg Gin Ala Leu Ile Gly Val Asn 450 455 460 Arg 465 As n Ala Al a Leu Gi u 545 Ile Thr Ala Asp Le u 625 Ala Ser Le u Ile Ile 705 Thr Glu Val1 Lys Arg Ala 515 Lys Se r Thr Ser Giu 595 His Met Arg Al a Ala 675 Pro Pro Leu Ala Val Asn 500 Arg Le u Asp Le u As n 580 Gly Asp Asp Al a Ala 660 Leu Gly Ser Ala Glu Arg 485 Asp As n Ala Al a Ser 565 Val Arg Arg Val1 Al a 645 Gly Gly Asp Gi y Al a 725 Glu 470 Ala Ala Gi u ValI Leu 550 Gly Glu Arg Gly Asp 630 Val1 His Arg Phe Thr 710 His Asp Glu Glu His Asp 535 Glu Vali Arg Pro Gin 615 Val1 Asp Leu Asp Gin 695 Val1 Leu Glu Gin Val1 Lys 520 Ala Val Tyr Ala Arg 600 Lys Giy Al a Thr Asp 680 Asp Ile Gly Ile Ala 490 Ala Pro Arg Phe Asp 570 Ala Phe Val1 Leu Val1 650 Leu Leu Tyr Glu Asp 730 Glu 475 Lys Al a Gly Al a Gly 555 Gi u Leu Ile Al a Phe 635 His Pro ValI Asp Ser 715 Le u Val1 Le u Leu Asp Lys 540 Arg Val1 Al a Al a Ser 620 Gin ValI Glu Thr Met 700 Ala Asp Leu Ala Asp Le u 525 Ala His Gly Asp Lys 605 Ala Thr Val1 Leu Val1 685 Gly Ile Val1 Lys Gin Al a 510 Asp Thr Glu Lys Ala 590 Met Tyr Pro Gly Lys 670 Gly Al a Asp Asp Val1 Leu 495 Leu Gin Ile Ala Glu 575 Phe Gly Ala Ala Met 655 Lys Gly Al a Leu Val1 735 Asp 480 Lys Thr As n Gly Glu 560 Gly Glu Gin Asp Giu 640 Se r Gi u Val1 Al a Ile 720 As n <210> 183 <211> 1971 <212> DNA <213> Corynebacterium glutarnicum <220> <221> CDS <222> (101)..(1948) <223> RXS00149 <400> 183 ttttcgtagg taaacacagg tgaaggcttt acaagcttgt atccaatagc tatccataag caaqagaaaq taaqtctacg gaactcccta cacaaaagca ttg act gat ctc aca 11! Leu Thr Asp Leu Thr aag act gcg gtg Lys Thr Ala Val gag gaa ctt tca Giu Giu Leu Ser gag Glu aac ctc gaa act Asn Leu Giu Thr tgg tac Trp Tyr 163 aag gct gtg Lys Ala Val gac att qcc Asp Ile Ala qcc Al a ggt gtt ttc gcg Gly Val Phe Ala aca cag aaa aaa Thr Gin Lys Lys gac atc ggc Asp Ile Gly aca ccg gat Thr Pro Asp 211 259 gta gat gtg tgg Val Asp Val Trp aaa ctc atc gtc Lys Leu Ile Val ggt gtt Gly Val gat atc aat ccg Asp Ile Asn Pro ctg Leu 60 tac acc aga gca. Tyr Thr Arg Ala gat Asp gag tcc cag agg Giu Ser Gin Arg ttc act gag gtt Phe Thr Glu Val ggt gag ttt ccc Gly Glu Phe Pro act agg gga acc Thr Arg Gly Thr 307 355 403 gtt gat ggt gaa Val Asp Gly Giu cgc Arg qtt ggt tgg ggt Val Gly Trp Gly gtt Val 95 act gag act ttc Thr Glu Thr Phe gga cat Gly His 100 gac agc ccg Asp Ser Pro ggc acc acc Gly Thr Thr 120 aat atc aac gct Asn Ile Asn Ala gtg ctg aat gct Val Leu Asn Ala ctg aat tct Leu Asn Ser 115 acg gca gct Thr Ala Ala aca ttg ggt ttt Thr Leu Gly Phe ttc tct gag gaa Phe Ser Glu Glu gat ctt Asp Leu 135 aaa qtt qct ctc Lys Val Ala Leu qaa Glu 140 gqc gtg tat ctc Gly Val Tyr Leu aac As n 145 atg gct ccg ttg Met Ala Pro Leu 451 499 547 595 643 att cat gcg ggt Ile His Ala Gly tcc acg tca gag Ser Thr Ser Giu gca gcg gcg ttg Ala Ala Ala Leu acg ttg gcg gag Thr Leu Ala Glu gaa Giu 170 gcc gga acg ttt Ala Gly Thr Phe ttt Phe 175 gct gcg ttg acc Ala Ala Leu Thr ttg ggt Leu Gly 180 tct cgt cct ttq acq qcq cag qtt gat ggt tcg cac agt gac acc att Ser Arg Pro Leu Thr Ala Gin Val Asp Gly Ser His Ser Asp Thr Ile 185 gaa gaa gca Glu Glu Ala 200 gtt cag ttg gca Val Gin Leu Ala gtg Val1 205 aat get tce aag Asn Ala Ser Lys gcg aat gtg Ala Asn Val 739 cgc gct Arg Ala 215 atc ttg gtg gat Ile Leu Val Asp ggt Gly 220 tee agt ttt tcc Ser Ser Phe Ser aac cag ggc gcg teg Asn Gin Gly Ala Ser 225 ggt gtg gat tat gte Gly Val Asp Tyr Val ga t Asp 230 gct caa gaa att Ala Gin Glu Ile ggt Giy 235 eta agt ate gcc Leu Ser Ile Ala 787 835 883 egt cgc ttg gtc Arg Arg Leu Val gat Asp 250 gea gge ett tcc Ala Gly Leu Ser aeg Thr 255 gaa get gea ctt Glu Ala Ala Leu aag eag Lys Gin 260 gtg gcg tte Val Ala Phe aag ctg cgt Lys Leu Arg 280 cgt Arg 265 ttt geg gte ace Phe Ala Val Thr gag cag tte geg Giu Gin Phe Ala cag att tet Gin Ile Ser 275 gag gtg ett Giu Vai Leu 931 979 gtg get ega egt Val Ala Arg Arg etg Leu 285 tgg gee agg gtg Trp Ala Arg Val ggt ttt Gly Phe 295 eea gag etg gee Pro Glu Leu Ala gea eca eag cat Ala Pro Gin His g eg Ala 305 gtg act gea ega Val Thr Ala Arg gcg Ala 310 atg ttt age cag Met Phe Ser Gin gat ccg tgg gtg Asp Pro Trp. Val atg ctg ege agt Met Leu Arg Ser 1023 1075 1123 gtt gca gct tte Val Ala Ala Phe gea ggc gtc ggt Ala Gly Val Gly gga Gly 335 gea ace gat gtg Ala Thr Asp Val gag gtt Giu Val 340 egt act ttc Arg Thr Phe aat ttc get Asn Phe Ala 360 gat gat geg ate eca gat gga gtt cet gga gtg teg agg Asp Asp Ala Ile Pro Asp Gly Val Pro Gly Val Ser Arg 345 350 355 1171 cac ege ate geg His Arg Ile Ala aat act aat ttg Asn Thr Asn Leu ttg eta gaa Leu Leu Glu 1219 gag tea Glu Ser 375 cat ctt ggt eac His Leu Gly His gtg Val1 380 gtt gat cet get Vai Asp Pro Ala gga tea tat ttc Giy Ser Tyr Phe gtg Val 390 gag age ttc ace Giu Ser Phe Thr ga t Asp 395 gat eta gcg gag Asp Leu Ala Giu aag Lys 400 gcg tgg get gtg Ala Trp Ala Val ttc Phe 405 1267 1315 1363 agt qg ate gaa Ser Gly Ile Giu gag gqe gga tae Giu Gly Gly Tyr agt Ser 415 gea get tgt gea Ala Ala Cys Ala tee ggc Ser Gly 420 aeg gtg act Thr Val Thr gee Al a 425 atg ctt gat cag Met Leu Asp Gin tgg gag cag act Trp Giu Gin Thr ege get gat Arg Ala Asp 435 1411 gtg gcg tcg Val Ala Ser 440 aga aag aag aag Arg Lys Lys Lys ctc Le u 445 act gga att aat Thr Gly Ile Asn ttc ccg aac Phe Pro Asn 1459 1507 ttq qcq S Leu Ala 455 gag tct ccg ctg Giu Ser Pro Leu gct gat cgt cgg Ala Asp Arg Arg gaa cct gca ggt Giu Pro Ala Gly gtg Val1 470 cgt cga tgg gca Arg Arg Trp Ala gat ttt gaa gcg Asp Phe Glu Ala ctg cgc aat cgt Leu Arg Asn Arg 480 cag atc acg atg Gin Ile Thr Met t cg Ser gat Asp 485 1555 1603 gct ttc ttg gaa Ala Phe Leu Giu aac ggc gcg agg Asn Giy Ala Arg att cct Ile Pro 500 ctg gga ccg Leu Gly Pro ctg ttg gct Leu Leu Ala 520 tcc aag cac aat Ser Lys His Asn cgc act ggt ttt Arg Thr Giy Phe act tcc aac Thr Ser Asn 515 caa ctt gtt Gin Leu Val 1651 1699 tcc ggt ggc att Ser Gly Gly Ile gca atc aac ccg Ala Ile Asn Pro ccc gqc Pro Gly 535 act gac gct ttt Thr Asp Ala Phe gca Ala 540 gaa gct gca cag Giu Ala Ala Gln gca ggc att gta Ala Gly Ile Vai gtg tgt gga acg Val Cys Gly Thr gac Asp 555 caa gag tat gcc Gin Giu Tyr Ala gaa Giu 560 acg ggg gag gga Thr Gly Giu Giy gcc Ala 565 gtc gaa aag ctc Val Giu Lys Leu gaa gcg gqc qtt Giu Ala Gly Vai cgc atc ctg ctt Arg Ile Leu Leu gct gqc Ala Gly 580 1747 1795 1843 1891 1939 gcg ccg aag Ala Pro Lys aac atg aca Asn Met Thr 600 ttg gga gct Leu Gly Ala 615 agc Se r 585 ttt gag ggc agc Phe Glu Gly Ser cat gcg ccc gat His Ala Pro Asp ggt tat ttg Gly Tyr Leu 595 cta gat gct Leu Asp Ala att gat gcc gcg Ile Asp Ala Ala acg ctg gct qac Thr Leu Ala Asp taaatcatga cgtcqatccc taa 1971 <210> 184 <211> 616 <212> PRT <213> Coryriebacterium giutamicum <400> 184 Leu Thr Asp Leu Thr Lys Thr Ala Val Pro Giu Giu Leu 1 5 10 Ser Giu Asn Leu Giu Thr Trp Tyr Lys Ala Val Ala Gly Val Phe Ala Arg Thr Gin 25 Lys Val Asp Thr Glu Asn Glu As n 145 Al a Ala His Lys Asn 225 Gly Ala Phe Val1 Ala 305 Met Thr Lys Thr Glu Arg Thr Al a Phe 130 Met Ala Le u Ser Arg 210 Gin Val1 Ala Al a Cys 290 Val1 Le u Asp Asp Thr Ser Gly Phe Le u 115 Thr Ala Ala Thr Asp 195 Ala Gly Asp Le u Gin 275 Giu Thr Arg Val1 Ile Pro Gin Thr Gly 100 As n Ala Pro Le u Le u 180 Thr Asn Al a Tyr Lys 260 Ile Val1 Al a Ser Glu 340 Gly Asp Arq Thr His Ser Ala Le u Tyr 165 Gly Ile Val Ser Val1 245 Gin Ser Leu Arg Thr 325 Val1 Asp Gly Lys 70 Val1 Asp Giy Asp Le u 150 Thr Ser Glu Arg Asp 230 Arg Val1 Lys Giy Al a 310 Val1 Arg Ile Val1 55 Phe Asp Ser Thr Leu 135 Ile Leu Arg Glu Ala 215 Ala Arq Ala Leu Phe 295 Met Ala Thr Ala Asp Thr Gly Pro Thr 120 Lys His Al a Pro Ala 200 Ile Gin Le u Phe Arg 280 Pro Phe Al a Phe Val1 Ile Glu Glu Lys 105 Thr Val1 Ala Giu Leu 185 Val1 Leu Glu Val1 Arq 265 Val1 Glu Ser Phe Asp 345 Val Pro Pro 75 Val1 Ile Gly Leu Gly 155 Al a Ala Leu Asp Gly 235 Ala Ala Arg Al a Arg 315 Ala Ala T rp Leu Gly Gi y Asn Phe Glu 140 Se r Gly Gin Ala Gly 220 Leu Gly Val1 Arg Val1 300 Asp Gly Ile Lys Thr Phe Gi y Al a 110 Phe Val1 Ser Phe Asp 190 As n Se r Ile Se r Asp 270 Trp Pro Trp Gi y Asp 350 Ile Al a Phe Th r Le u Glu Le u Val1 160 Al a Se r Se r Se r Al a 240 Gi u Gin Arg His As n 320 Al a Val1 Pro Gly Val 355 Leu Leu Leu 370 Gly Gly Ser 385 Ala Trp Ala Ala Cys Ala Gin Thr Arg 435 Asn Glu Phe 450 Val Glu Pro 465 Arg Asn Arg Ile Thr Met Gly Phe Thr 515 Pro Gly Gin 530 Ala Ala Gly 545 Thr Gly Glu Ile Leu Leu Pro Asp Gly 595 Asp Leu Leu 610 <210> 185 <211> 1179 <212> DNA Ser Le u Tyr Val1 Se r 420 Ala Pro Ala Ser Ile 500 Ser Le u Ile Gly Al a 580 Tyr Asp Arg Glu Phe Phe 405 Gly Asp Asn Gly Asp 485 Pro As n Val1 Val1 Al a 565 Gly Leu Al a Asn Glu Val1 390 Ser Thr Val1 Leu Val 470 Ala Leu Leu Pro Val1 550 Val1 Ala As n Leu Phe Ser 375 Glu Gly Val1 Ala Al a 455 Arg Phe Gly Leu Gly 535 Val Glu Pro Met Gly 615 His Leu Phe Glu Ala 425 Arg Ser T rp Glu Le u 505 Se r Asp Gly Le u Ser 585 Ile Arg Gly Thr Al a 410 Met Lys Pro Al a Lys 490 Ser Gly Al a Th r Arg 570 Phe Asp Ile His Asp 395 Glu Leu L ys Leu Al a 475 Asn Lys Gly Phe Asp 555 Giu Giu Ala Ala Val1 380 Asp Gly Asp Lys Pro 460 Asp Gly His Ile Ala 540- Gin Ala Gly Ala Arg 365 Val1 Leu Gly Gin Le u 445 Al a Phe Ala As n Glu 525 Glu Glu Gly Ser Ala 605 Asn Thr Asn ASP Ala Tyr Thr 430 Thr Asp Glu Arg Ile 510 Ala Ala Tyr Val1 Al a 590 Thr Pro Glu Ser 415 Trp Gly Arg Al a Pro 495 Arg Ile Ala Ala Glu 575 His Leu Al a Lys 400 Al a Glu Ile Arg Le u 480 Gin Thr As n Gin Glu 560 Arg Al a Al a <213> Corynebacterium glutamicum <220> <221> CDS <222> (1156) <223> RXS02106 <400> 185 ggtcgccgct tttcgacgcc cgcctgcggc gggatgactg aagcaaaatc tctttagcaa attcggttac tgtggqgcgc tgatggaggq qcgcgtcgac atg aat aac cat Met Asn Asn His 1 gag ctc aaa gta Giu Leu Lys Val ggt gga aag ctt Gly Gly Lys Leu gtc gtt gat gtg Val Val Asp Val acc acc Thr Thr gat ctg gat Asp Leu Asp gaa ccc gat Giu Pro Asp t cc Ser att gct qac gtg Ile Ala Asp Vai att tcc ggc gat Ile Ser Giy Asp ttc ttc ctc Phe Phe Leu cag ggg qcg Gin Gly Ala gag gca ttc ttc qcc ctt ggc cgg gcg Giu Ala Phe Phe Ala Leu Gly Arg Ala ctg Leu tcg gtg Ser Vai ggt gat aac act Giy Asp Asn Thr qat Asp cgt ttg cag gca Arg Leu Gin Ala ttg gat gca gcg Leu Asp Ala Ala gcg gaa tat gat Ala Giu Tyr Asp gtt gag cta cac Vai Giu Leu His ggC Gly ttt agc act gcg Phe Ser Thr Ala gat Asp att gct tta gct Ilie Ala Leu Ala gtg Val1 cgt cgg gca gtc Arg Arg Ala Val ggc gcg caa gat Gly Ala Gin Asp ttc acc Phe Thr 100 gat tat gaa Asp Tyr Giu aac gtt gcg Asn Val Ala 120 gaa atc ctg cac cca ggg gtg ctt cct Glu Ile Leu His Pro Gly Val Leu Pro 110 acc cca ctt Thr Pro Leu 115 agt ggt cag Ser Gly Gin ttg gat gag ctc Leu Asp Giu Leu ttg gac caa gtt Leu Asp Gin Val gcc Ala 130 cgt ggc Arg Gly 135 ccg acg atg cgc Pro Thr Met Arg tgq gat tgg gat Trp Asp Trp Asp ga t Asp 145 cgc gcc aca gtg Arg Ala Thr Val atc Ile 150 ggt agt ttc cag Gly Ser Phe Gin tat gtc aat gaa Tyr Val Asn Glu sac caa gsa ggc Asn Gin Giu Gly aat gas cat ggt Asn Giu His Gly gtg Val1 170 acc gtg gta cga Thr Val Val Arg atg tct ggt ggc Met Ser Gly Gly ggt gca Gly Ala 180 atg ttt atg Met Phe Met gsa tct ctc Giu Ser Leu 200 gag Giu 185 ggc ggc aac tgc Gly Gly Asn Cys acc tat tcc ctg Thr Tyr Ser Leu tat gca ccg Tyr Ala Pro 195 gaa tat ttg Giu Tyr Leu gtt gct ggt ttg Val Ala Gly Leu agc Ser 205 tat gag cag tcc Tyr Glu Gin Ser gat cgt tgg gtg att gct gcg ctg aag aca cac gat gtt gac qct. tgg Asp Arg Trp Val Ile Ala Ala Leu Lys Thr His Asp Val Asp Ala Trp 215 220 225 tac qtg cct atc aat gac ate ace tee ace ggc gga aaa atc qgt qqc 835 Tyr Val Pro Ile Asn Asp Ile Thr Ser Thr Gly Giy Lys Ile Gly Gly 230 235 240 245 gct gca cag aaa cgt cgc agt ggc gca gte etc cac cac gtg acc atg 883 Ala Ala Gin Lys Arg Arg Ser Gly Ala Val Leu His His Val Thr Met 250 255 260 tcc tat gac atc gat gcg gac atg atg acc cag gtg ttg cgc att gga 931 Ser Tyr Asp Ilie Asp Ala Asp Met Met Thr Gln Val Leu Arg Ile Gly 265 270 275 aag gtg aag att tce qac aag ggt ctt cge age qca aaq aag cgc gtt 979 Lys Vai Lys Ie Ser Asp Lys Gly Leu Arg Ser Ala Lys Lys Arq Val 280 285 290 gat ect ctg cgc cgc caa aca ggt gca. tea cgt gag caa ate ate gac 1027 Asp Pro Leu Arg Arg Gin Thr Gly Ala Ser Arg Giu Gin Ile Ile Asp 295 300 305 ace eta aag tee aca ttc agt get agg tac ggc gcg caa gaa gta gag 1075 Thr Leu Lys Ser Thr Phe Ser Ala Arg Tyr Gly Ala Gin Giu Val Glu 310 315 320 325 ctc agc gat gaa gat ttc geg gca ggc cac gac eta qta aaa acc aaa 1123 Leu Ser Asp Glu Asp Phe Ala Ala Gly His Asp Leu Val Lys Thr Lys 330 335 340 tac gcc ace gag gag tgg act aag cga gtt caa tagtttctat ggatetgeae 1116 Tyr Ala Thr Glu Giu Trp Thr Lys Arg Val Gin 345 350 aag 1179 <210> 186 <211> 352 <212> PRT <213> Corynebacterium giutamicum <400> 186 Met Asn Asn His Phe Glu Leu Lys Val Pro Gly Gly Lys Leu Val Val 1 5 10 Val Asp Val Thr Thr Asp Leu Asp Ser Ilie Ala Asp Val Lys Ile Ser 25 Giy Asp Phe Phe Leu Glu Pro Asp Giu Ala ?he Phe Ala Leu Gly Arg 40 Ala Leu Gin Gly Ala Ser Val Gly Asp Asn Thr Asp Arq Leu Gin Ala 55 Lys Leu Asp Ala Ala Leu Ala Glu Tyr Asp Asp Val Giu Leu His Gly 70 75 Phe Ser Thr Ala Asp Ile Ala Leu Ala Val Arg Arg Ala Val Thr Gly 90 Ala Gin Asp Phe Thr Asp Tyr Glu Trp Glu Ile Leu His Pro Gly Val 100 105 110 Leu Pro Thr Pro Leu Asn Val Ala Leu Asp Glu Leu Leu Leu Asp Gin 115 120 125 Val Ala Ser Gly Gin Arg Gly Pro Thr Met Arg Ile Trp Asp Trp Asp 130 135 140 Asp Arg Ala Thr Val Ile Gly Ser Phe Gin Ser Tyr Val Asn Glu Ile 145 150 155 160 Asn Gin Glu Gly Val Asn Glu His Gly Val Thr Val Val Arg Arg Met 165 170 175 Ser Gly Gly Gly Ala Met Phe Met Glu Gly Gly Asn Cys Ile Thr Tyr 180 185 190 Ser Leu Tyr Ala Pro Glu Ser Leu Val Ala Gly Leu Ser Tyr Glu Gin 195 200 205 Ser Tyr Glu Tyr Leu Asp Arg Trp Val Ile Ala Ala Leu Lys Thr His 210 215 220 Asp Val Asp Ala Trp Tyr Val Pro Ile Asn Asp Ile Thr Ser Thr Gly 225 230 235 240 Gly Lys Ile Gly Gly Ala Ala Gin Lys Arg Arg Ser Gly Ala Val Leu 245 250 255 His His Val Thr Met Ser Tyr Asp Ile Asp Ala Asp Met Met Thr Gin 260 265 270 Val Leu Arg Ile Gly Lys Val Lys Ile Ser Asp Lys Gly Leu Arg Ser 275 280 285 Ala Lys Lys Arg Val Asp Pro Leu Arg Arg Gin Thr Gly Ala Ser Arg 290 295 300 Glu Gin Ile Ile Asp Thr Leu Lys Ser Thr Phe Ser Ala Arg Tyr Gly 305 310 315 320 Ala Gin Glu Val Glu Leu Ser Asp Glu Asp Phe Ala Ala Gly His Asp 325 330 335 Leu Val Lys Thr Lys Tyr Ala Thr Glu Glu Trp Thr Lys Arg Val Gin 340 345 350 <210> 187 <211> 876 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(853) <223> RXS01746 <400> 187 aaaccgccac tcccctttca ctggggagtg gcggttttgt tgacttatca accttgttag ggctagggtg gatatotatc cgtttcatgc atgcagtgtg atg act gca cca aga 11, Met Thr Ala Pro Arg 1 gat cot ttt ttc Asp Pro Phe Phe ccc Pro gca gat ctt tct Ala Asp Leu Ser atc Ile 15 090 gog tot gca Arg Ala Ser Ala gag ccc Giu Pro att gaa att Ile Glu Ile tat caa gca Tyr Gin Ala cgg ttg qgt ttg Arg Leu Giy Leu gat tat caa gag Asp Tyr Gin Giu 9cc tgg gat Ala Trp Asp atc cot gat Ile Pro Asp 211 259 gag ott got aco Giu Leu Ala Thr agg got aat gat Arg Ala Asn Asp gaa Glu cag ctg Gin Leu ctt att ttg gag Leu Ile Leu Glu cac His ocg tog gtg tat Pro Ser Vai Tyr gca ggt aag cgc Ala Giy Lys Arg acc Thr cag cog gaa gat Gin Pro Giu Asp coo aoc aac gga Pro Thr Asn Gly cog gtg ato aat Pro Val Ile Asn 307 355 403 gat cgt ggt ggt Asp Arg Gly Gly ogo Arg atc acg tgg oat Ile Thr Trp His ggt Gly 95 cot ggc caa ttg Pro Gly Gin Leu gtg atc Val Ile 100 tat ccg ato Tyr Pro Ile aga 090 ctc Arg Arg Leu 120 aaa tta goc gat Lys Leu Ala Asp 009 Pro 110 ato gat gtg gtt Ile Asp Val Val gat tao gta Asp Tyr Val 115 atg ggt gtt Met Gly Val gag gaa gcg oto Giu Giu Ala Leu caa gtt gto 990 Gin Vai Val Giy 900 990 Ala Giy 135 got ggg 090 att Ala Gly Arg Ile gat Asp 140 999 ogt tog ggt Gly Arg Ser Giy tgg gtg oca qot Trp Val Pro Ala gat ggt tgg gtg Asp Gly Trp Val ago aag gtt 909 Ser Lys Val Ala 900 Al a 160 atc 990 att oga Ile Gly Ile Arg ata Ile 165 act ogt ggt gtt Thr Arg Gly Val goa Ala 170 atg cao ggt gtg Met His Giy Val ato aao tgo aao Ile Asn Cys Asn aao aog Asn Thr 180 ttg gat tto Leu Asp Phe ttg ago aca Leu Ser Thr 200 gag cac atc att Giu His Ile Ile tgt 990 att got Cys Gly Ile Ala gat gca 990 Asp Ala Gly 195 gtt gag gaa Val Giu Glu 691 739 oto tog agg gaa Leu Ser Arg Giu aaa agg gao gtt Lys Arg Asp Val tca Ser 210 tta gtc gag Leu Val. Giu 215 ctg gtt gtt Leu Val Val 230 aat ctc cct Asn Leu Pro c ca Pro tct Ser aaa Lys tcg Ser ga t Asp cgg Arg 250 atc cgc gca ttg gat gat gct ttg gct ggt cgg 787 Ile Arg Ala Leu Asp Asp Ala Leu Ala Gly Arg 220 225 cat tct ttc ggc agc gcg ccc gac cca act aag .835 His Ser Phe Gly Ser Ala Pro Asp Pro Thr Lys 235 240 245 ggq tagtacgagg aattttgtcg gtg 876 Gly <210> 188 <211> 251 <212> PRT <213> Corynebacterium glutamicum <400> 188 Met Thr Ala Pro Arg Asp Pro Phe Phe 1 Ala Gin Asp Thr Pro Gly Val1 Gly Val1 145 Ile As n Ile Val1 Ser Glu Glu Ala Val Gin Val1 Asp 130 Trp Gly cys Ala Ser 210 Al a Al a Ile Gi y Ile Leu Asp 115 Met Val1 Ile As n Asp 195 Val1 5 Pro Asp Asp Arg Al a Ile Val1 Val1 Al a Ile 165 Thr Gly Glu Ile Tyr Gin Thr 7 0 Asp Tyr Arg Al a His 150 Thr Leu Leu Leu Glu Gin Leu 55 Gin Arg Pro Arg Gly 135 Asp Arg Asp Ser Val1 215 Ile Ala 40 Leu Pro Gly Ile Leu 120 Al a Gly Gly Phe Thr 200 Glu Pro 10 Arg Leu Leu Asp Arg 90 Lys Glu Arg Val1 Al a 170 Glu Ser Ser Ala Leu Al a Gi u Le u 75 Ile Le u Al a Ile Asp 155 Met His Arq Ile Asp Gly Thr His Pro Thr Ala Leu Asp 140 Ser His Ile Glu Arg 220 Leu Leu Arg Pro Thr Trp Asp Ile 125 Gly Lys Gly Ile Le u 205 Ala Se r Ile Arg Ser As n His Pro 110 Gin Arg Val Val1 Pro 190 Lys Leu Ile Asp Ala Val1 Gly Gly Ile ValI Ser Al a Ala 175 cys Arg Asp Arg Tyr As n Tyr Leu Pro Asp ValI Gly Ala 160 Ile Gly Asp Asp Ala Leu Ala Gly Arg Leu Vol Val Ser 225 230 Asp His Ser Phe Gly Ser Ala 235 240 Pro Asp Pro Thr Lys Asn Leu Pro Lys Arg Gly 245 250 <210> 189 <211> 1167 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (1144) <223> RXS01747 <400> 189 cgaagtagag ccgattgcag aatcggcgga atgoqacgtc gaaaagcgtt taagctttcc ctaaaaatat cactaactcg aaagatgtaa ggttgcattt gtg act atc gco cct Val Tlhr Ile Ala Pro goa gga cga cga Giu Giy Arg Arg cta cgc gtc gaa Leu Arg Vol Giu gct Ala cga aac tca gaa Arg Asn Ser Giu acc cc9 Thr Pro ott gag acg Ile Glu Thr cct cga tgg att Pro Arg Trp Ile aoc cog gtc aaa Asn Gin Vol Lys aac gga cct Asn Gly Pro gag tat cag gat atg aag gaa cgt gtc gct ggc gca tca cta cac act Giu Tyr Gin Asp Met Lys Giu Arg Vol Ala Giy Ala Ser Leu His Thr 45 gtg tgt Vol Cys cag gag gct ggc Gin Glu Ala Gly cct oat otc cat Pro Asn Ile His gag Giu tgt tgg gaa tcc Cys Trp Giu Ser cgt Arg gag gca acc ttc Giu Ala Thr Phe ctc Le u ott ggt ggc gcc Ile Gly Gly Ala tgc tct cgc cgc Cys Ser Arg Arg 307 355 403 got ttc tgc atg Asp Phe Cys Met aac tcg gct cgc Asn Ser Ala Arg gag cco ctc gac Glu Pro Leu Asp cgc ggt Arg Gly 100 gag cca ctg Giu Pro Leu tcc acc atc Ser Thr Ile 120 cgt Arg 105 gtc gct gag tct Vol Ala Glu Ser gt t Val1 110 cgt gag atg cog Arg Glu Met Gin ctg aot tac Leu Asn Tyr 115 gao ggc gca Glu Gly Ala 451 499 acc ggt gtt 0CC Thr Gly Vol Thr cgt Arg 125 got got ctg got Asp Asp Leu Asp got Asp 130 tgg ctg Trp Leu 135 tac tco gao gtg Tyr Ser Giu Vol cgt aag atc cac Arg Lys Ile His ctg aac cco cac Leu Asn Pro His acc ggt gtg gao aac ctg gtg cct got ttc tcc ggc aag aag gat ctg Thr 150 Gly Vai Giu Asn Val Pro Asp Phe Gly Lys Lys Asp Le u 165 ctg cag gaa gtt. Leu Gin Giu Val gaa tcc ogc oca Glu Ser Arg Pro gag Giu 175 gtt tto gct cac Val Phe Ala His aao gtg Asn Val 180 gaa act gtg Giu Thr Val gag cgt tca Giu Arg Ser 200 cca Pro 185 cgt att ttc aag Arg Ile Phe Lys att. cgc cca gca Ile Arg Pro Ala ttc cgc tac Phe Arg Tyr 195 ggt ctg gtg Gly Leu Val ctt gat gtg atc Leu Asp Val Ile cag got cgc gat Gin Ala Arg Asp ttc Phe 210 acc aag Thr Lys 215 tcc aac ctg att Ser Asn Leu Ile ttg Leu 220 ggc atg ggt gaa Giy Met Gly Glu aag gaa gaa atc Lys Giu Giu Ile gag gcg ctg cag Giu Ala Leu Gin ctg cac gao got Leu His Asp Ala ggC Gly 240 tgt gao atc atC Cys Asp Ile Ile 787 835 883 atc acc cag tac Ile Thr Gin Tyr Ctg Leu 250 cgt oct ggt cot Arg Pro Giy Pro ttc cac ccc atc Phe His Pro Ile gag cgt Giu Arg 260 tgg gtg aag Trp Val Lys atg ggo tto Met Giy Phe 280 cct Pro 265 gag gag ttc ctc Glu Glu Phe Leu cac got gat got His Aia Asp Ala gca aag gaa Ala Lys Glu 275 too tot tao Ser Ser Tyr got got gtt atg Ala Ala Val Met ggo oca ttg gtt Gly Pro Leu Val Cgt Arg 290 cgt gca Arg Ala 295 ggc cgt ctg tao Gly Arg Leu Tyr gog Ala 300 cag gcc atg gag Gin Ala Met Glu ogt ggc gag gaa Arg Gly Giu Glu oca gca cac cto Pro Ala His Leu cac otg aag gat His Leu Lys Asp act Thr 320 too gga gga too Ser Giy Gly Ser acc Th r 325 1027 1075 1123 goc cag gaa gca Ala Gin Glu Ala t ct Se r 330 aca ott ctg gag Thr Leu Leu Glu tao ggt got too Tyr Giy Ala Ser gaa gao Glu Asp 340 aco oca gtg Thr Pro Val gtg Val1 345 too tto aao Ser Phe Asn taagooogaa gttttttaao ogo 1167 <210> 190 <211> 348 <212> PRT <213> Corynebacterium glutamiloum <400> 190 Val Thr Ile Ala Pro Giu Gly Arg Arg Leu Leu Arg Val Glu Ala Arg 1 5 10 is Asn Ser Glu Thr Pro Ile Giu Thr Lys Pro Arg Trp Ile Arg Asn Gin Val1 Al a Glu Cys Pro Met Asp Glu 145 Gl y Phe Pro Asp Thr 225 Cys His Asp Val1 Phe 305 Ser Gi y Lys Ser Cys Ser Leu Gin Asp 130 Leu Lys Ala Ala Phe 210 Lys Asp Pro Ala Arg 290 Arg Giy Ala As n Le u T rp Arg Asp Leu 115 Glu Asn Lys His Phe 195 Gl y Giu Ile Ile Ala 275 Ser Gly Gi y Ser Gly His Giu Arg Arg 100 Asn Gly Pro Asp Asn 180 Arg Leu Giu Ile Giu 260 Lys Ser Giu Ser Glu Pro Thr Ser Cys Gly T yr Ala His Leu 165 Val1 T yr Val1 Ile Thr 245 Arg Giu Tyr Giu Thr 325 Asp Giu Val1 Arg 70 Asp Giu Ser Trp Thr 150 Leu Giu Glu Thr Thr 230 Ile T rp Met Arg Ile 310 Ala T hr Gin 40 Gin Al a Cys Leu Ile 120 Tyr Val1 Giu Val1 Se r 200 Ser Ala Gin Lys Ph e 280 Gly Ala Glu Val 25 Asp Giu Thr Met Arq 105 Thr Ser Giu Val1 Pro 185 Leu Asn Leu Tyr Pro 265 Al a Arg His Ala Val1 Met Ala Phe Ile 90 Val1 Gly Glu As n Phe 170 Arg Asp Leu Gin Leu 250 Giu Ala Leu Leu Se r 330 Ser Lys Gly Le u 75 Asn Al a Val1 Val1 Leu 155 01 u Ile Val1 Ile Asp 235 Arg Gli Val1 T yr Ala 315 Thr Phe Glu Cys Ile Ser Giu Thr ValI 140 Val1 Ser Phe lie Leu 220 Leu Pro Phe Met Ala 300 His Leu Asn Arg Pro Gly Al a Ser Arg 125 Arg Pro Arg Lys Arg 205 Gi y His Giy Leu Ser 285 Gin Leu Le u Val1 Asn Gly Arg Val1 110 Asp Lys Asp Pro Arg 190 Gin Met Asp Pro Glu 270 Gly Al a Lys Glu Ala Ile Ala Pro Arg Asp Ile Phe Giu 175 Ile Ala Gly Al a Leu 255 His Pro Met Asp Arg 335 Gi y His As n 01 u 01 u Le u His Ser 160 Val1 Arg Arg Glu Gly 240 Phe Al a Leu Giu Thr 320 Tyr (210> 191 <211> 903 <212> DNA <213> Corynebacterium giutamioum <220> <221> CDS <222> (101)..(880) <223> RXC01748 <400> 191 atcaooaaat gtggcggttt tgcgtcgaaa agcgtgctct oattttcgog gtttcctcac aatcgootat tgttaagtac aag Lys gca Al a caa Gin Ott Leu ca g Gin a tg Met gaa Glu ggo Gi y cag Gin gtC Val1 150 a ag cag Gin cag Gin c Arg ggCit Gly tgg Trp ttt Phe ggt Gly 9t g Val atg Met 135 ggc Gi y aag ga t Asp aa g Ly s ca q Gin cog Pro atg Met ttc Phe cag Gin 105 at g Met gca Al a qgo Gi y otg aaa Lys gag Giu gat Asp ctg Le u Ott Leu acc Thr gg t Gly ac Thr gtg Val1 tc Ser aac 900 Al a cgc Arg got Ala ott Leu 60 atc Ile cgc Arg got Ala cgo Arg c Arg 140 cac His gtg aag Lys caa Gin 30 at t Ile Ctc Leu att Ile gag Gi u tgg Trp 110 aag Lys at t I le ctg Leu oct gta Val tgg Trp ott Leu ggt Giy gca Al a 80 gao Asp gtg Val1 got Al a otg Leu oca Pro 160 gt t ttotaoaoct ctttgaggtt atg goa gao gog aaa 11~ Met Ala Asp Ala Lys 1 aga goa gco aag aag 16: Arg Ala Ala Lys Lys cag gtc tto aao atg 21: Gin Val Phe Asn Met otg ttg cto gct att 25 Leu Leu Leu Ala Ile ttg att tgg ggt ggt 30 Leu Ile Trp Gly Gly ggt gtt gta got gca 35 Gly Val Val Ala Ala gtg tao aag ogc gco 40 Vai Tyr Lys Arg Ala 100 gag aao cto ogo tot 45 Giu Asn Leu Arg Ser 115 gtt gca gtg aoc act 49 Val Ala Val Thr Thr 130 tgt ggt gtt gtg ctg 54 Cys Gly Val Val Leu 145 atg ott gog cag caa 59 Met Leu Ala Gin Gin 165 cca gtg tat gaa ato 64 3 1 9 7 3 1 9 7 3 Lys Lys Arg Leu Asn Arg Val Ala Pro Gly Val Pro Val Tyr Glu Ile 170 175 180 ate acg ggc aac ggc gaa ggc cag ace ect atc gcg aag ctg eag egt 691 Ile Thr Gly Asn Gly Glu Gly Gin Thr Pro Ile Ala Lys Leu Gin Arg 185 190 195 gaa ctg gte aag etg cet egc aac tac aag aag aac gac gte gct gce 739 Giu Leu Val Lys Leu Pro Arg Asn Tyr Lys Lys Asn Asp Val Ala Ala 200 205 210 etg gcc get egc att gag gct atg gac aat gte gga aae gct cct ggc 787 Leu Ala Ala Arg Ile Glu Ala Met Asp Asn Val Gly Asn Ala Pro Gly 215 220 225 gga tet ttg cet aag ggt eca ttq eea aag gge qea age atg tee gqt 835 Giy Ser Leu Pro Lys Gly Pro Leu Pro Lys Gly Ala Ser Met Ser Gly 230 235 240 245 atg aae ege ege get cge cga eag get gaa egc aag gge gag gct 880 Met Asn Arq Arg Ala Arg Arg Gin Ala Glu Arg Lys Gly Glu Ala 250 255 260 taaageettt tegctttege gte 903 <210> 192 <211> 260 <212> PRT <213> Corynebacterium glutamicum <400> 192 Met Ala Asp Ala Lys Lys Gin Ala Asp Lys Ala Ala Lys Lys Gin Val 1 5 10 Arg Ala Ala Lys Lys Ala Gin Arg Lys Glu Thr Arg Ser Gin Met Trp 25 Gin Val Phe Asn Met Gin Arg Lys Gin Asp Lys Ala Leu Ile Pro Leu 40 Leu Leu Leu Ala Ile Leu Gly Ile Pro Leu Val Leu Phe Leu Ile Gly 55 Leu Ilie Trp Gly Gly Gin Trp Trp Met Leu Pro Ile Gly Ile Ala Ala 70 75 Gly Val Val Ala Ala Met Phe Ile Phe Thr Arg Arg Val Glu Arg Asp 90 Val Tyr Lys Arg Ala Giu Gly Gin Gin Gly Ala Ala Gly Trp Ala Vai 100 105 110 Glu Asn Leu Arg Ser Gly Val Gly Met Thr Trp Arg Thr Lys Thr Ala 115 120 125 Val Ala Val Thr Thr Gin Met Asp Ala Val His Arg Val Ile Gly Leu 130 135 140 Cys Giy Val Val Leu Val Gly Glu Gly Ser Pro His Arg Leu Lys Pro 145 150 155 160 Met Pro Al a As n Gl y 225 Al a Lys Al a Tyr Le u 195 Val1 Al a Met Glu Gin Glu 180 Gin Ala Pro Se r Al a 260 Gin 165 Ile Arg Al a Gi y Gi y 245 Lys Ile Glu Leu Gly 230 Met Arg Gly Val1 200 Ala Le u Arg be u Asn 185 Lys Arg Pro Arg As n 170 Gly Leu Ile Lys Ala 250 Val Gly Arg Ala 220 Pro Arg Gly 175 Pro Lys As n Lys Glu 255 Val1 Ile Lys Val1 Gi y 240 Arg c210> 193 <211> 936 <212> DNA <213> Corynebacterium glutamicun <:220> <221> CDS <222> (913) <223> RXC00354 <400> 193 ggcttgtcgg taaggctgca gggtagcggg agtttccttc agattggaag ttctttaatt ttctcgatta tgtacctcat ttacgcgtaa agtttggggc atg gga aag tta ctt ttC Phe Cgt Arg gtg Val1 tgg Trp gaa Giu acc gta Val1 t cg Ser tac T yr ga t Asp agc Ser cg c at c Ile gt t Val1 agc Se r gg a Gi y ca g Gin att ggt Gi y gac Asp t ct Ser gtg ValI gag Glu gtg ggC Gly gcg Ala ggt Gly gat Asp tct Ser 75 gag ct g Leu aaq Lys agc Ser att I le ca c His tac gat Asp 15 gca Ala g ct Ala ggC Gly cgc Arg aac Gly aat Asn aaa Lys act Th r ggt Gly tcg Ser t tg be u gtt Val cac His cag Gin tat T yr gag Glu ttt be u ccg Pro cg c Arg ttq be u gt g Val1 gag Glu tat 115 163 211 259 307 355 403 Thr Arg His Ile Glu Trp Leu Tyr As n Arg Gly Leu Glu Phe Tyr 100 ctc gag tcc Leu Giu Ser tct aag cca Ser Lys Pro 120 aac Asn 105 aao ggt ttg tat gca agc cgt ggt ttc Asn Gly Leu Tyr Ala Ser Arg Gly Phe 110 cgt gag gct. Arg Glu Ala 115 gtg aca gtc Val Thr Val gtg otg tot ogc Val Leu Ser Arq ct t Leu 125 tcq gag aag aco Ser Giu Lys Thr gat agc Asp Ser 135 atg tac ccg gat Met Tyr Pro Asp ttc tgg ggc gog Phe Trp Gly Ala ago Ser 145 ott gat cgt gac Leu Asp Arq Asp gtg aac aag atc Val Asn Lys Ile tac ato ttc aat Tyr Ile Phe Asn t ct Ser 160 cag gaa gat ttg Gin Glu Asp Leu ga c Asp 165 gca gcg cgt gag Ala Ala Arg Glu gcg Ala 170 tto oct aac ctg Phe Pro Asn Leu cac acc acg tgg His Thr Thr Trp ggt ggt Gly Gly 180 cag acg ggt Gin Thr Gly atc ggc gtg Ile Gly Val 200 ttg ttc ggc acq Leu Phe Gly Thr atc Ile 190 ggt gtg tot gtc Gly Vai Ser Val aao aag aag Asn Lys Lys 195 cgc goa aac Arg Ala Asn gat cgo ctg ctg Asp Arg Leu Leu tac ctg aac gca Tyr Leu Asn Ala gat Asp 210 acc att Thr Ile 215 gog ttc ggc gao Ala Phe Gly Asp gat gag gat ctc Asp Glu Asp Leu ota ttt gag gcg Leu Phe Giu Ala agoc Ser 230 gct tac ggc gtc qog atg ggc gag gcc Ala Tyr Gly Val Ala Met Gly Glu Ala 235 acc Thr 240 gaa tcg otc aag Giu Ser Leu Lys gct got gac otg Ala Ala Asp Leu gto Val 250 acg gat got gtt Thr Asp Ala Val oag gao ggc ttg cgo aat Gin Asp Gly Leu Arg Asn 260 tgaccooatc aaagaacttc gcg ttt tta Ala Phe Leu Ott gag ott ato Leu Giu Leu Ile qac gc Asp Ala 270 <210> 194 <211> 271 <212> PRT <213> Corynebaoterium giutamioum <400> 194 Met Gly Lys Leu Leu Phe Val Asp Ile 1 5 Ser Asn Glu Val Pro Arq Ser Ala Val 25 Gly Gly Thr Leu Leu Asp Tyr 10 Asp Ala Ile Arg Lys Ala Arg Ala Lys Gly His Arg Val Tyr Leu Ser Ser Gly Arg Ser Ser Ala Giu 40 Val Thr Ser Gin Leu Trp Asp Ile Giy Val Asp Gly Leu Ile Gly Ala 55 Asn Giy Gly Tyr Val Giu Ser Ala Gin Glu Ser Val Phe His Arg Arg 70 75 Leu Ser Gly Glu Glu Thr Arq His Ile Val Glu Trp Leu Tyr Asn Arg 90 Gly Leu Glu Phe Tyr Leu Giu Ser Asn Asn Gly Leu Tyr Ala Ser Arq 100 105 110 Gly Phe Arg Giu Ala Ser Lys Pro Val Leu Ser Arg Leu Ser Giu Lys 115 120 125 Thr Asp Val Thr Val Asp Ser Met Tyr Pro Asp Met Phe Trp Gly Ala 130 135 140 Ser Leu Asp Arg Asp Asp Vai Asn Lys Ile Ser Tyr Ile Phe Asn Ser 145 150 155 160 Gin Glu Asp Leu Asp Ala Ala Arq Glu Ala Phe Pro Asn Leu Glu His 165 170 175 Thr Thr Trp Gly Gly Gin Thr Gly Ala Leu Phe Gly Thr Ile Gly Val 180 185 190 Ser Val Asn Lys Lys Ile Gly Val Asp Arg Leu Leu Lys Tyr Leu Asn 195 200 205 Ala Asp Arg Ala Asn Thr Ile Ala Phe Gly Asp Ser Asp Glu Asp Leu 210 215 220 Ser Leu Phe Giu Ala Ser Ala Tyr Gly Val Ala Met Gly Glu Ala Thr 225 230 235 240 Giu Ser Leu Lys Ala Ala Ala Asp Leu Val Thr Asp Ala Val Gly Gin 245 250 255 Asp Gly Leu Arg Asn Ala Phe Leu Lys Leu Giu Leu Ile Asp Ala 260 265 270 <210> 195 <211> 1740 <212> DNA <213> Corynebacteriun glutamicun <220> <221> CDS <222> (101)..(1717) <223> RXC01749 <400> 195 ggtttttgcg tgctctggtt tagggactgg ttttgggaac gtgcccagtt ccacatcaaa taacgctgag gtcgtactta atccatgaga tcatgaatqg gtg agc ttc ctt gta 115 Val Ser Phe Leu 1 gaa aat caa tta ctc gcg ttg gtt Glu Asn Gin Leu Ala Leu Val gtc Val1 ttc Phe 30 ato atg acg gtc gga Ile Met Thr Val Gly cta ttg Leu Leu ctc ggc cgc Leu Gly Arg ctg ttt gta Leu Phe Val ato Ile aaa att ttc ggg Lys Ile Phe Gly cgt ctc ggc gtc Arg Leu Gly Val gcc gct gta Ala Ala Val att tcc gtc Ile Ser Val 211 259 ggt ota gcg cta Gly Leu Ala Leu acc att gag ccg Thr Ile Glu Pro ga t Asp cca tcc Pro Ser ctc att tac gtg Leu Ile Tyr Val gt t Val1 gga ctg tcg ctt Gly Leu Ser Leu gtc tao acg atc Vai Tyr Thr Ile ctg gaa gcc ggc Leu Giu Ala Gly gga ttc ttc acc too atg aaa acc act Gly Phe Phe Thr Ser Met Lys Thr Thr ctg cgc aac aac Leu Arg Asn Asn gca Ala ctg acc ttg gqc gcc atc atc gcc acc Leu Thr Leu Gly Ala Ile Ile Ala Thr 95 aeg gca Thr Ala 100 ctc gca tgg Leu Ala Trp gcc ggc atg Ala Gly Met 120 cto. atc aca gtt Leu Ile Thr Val aac ato gat gc Asn Ile Asp Ala qco tcc gqo Ala Ser Gly 115 atg gcc goa Met Ala Ala ctc acc ggc gog Leu Thr Gly Ala acc aac acc oca Thr Asn Thr Pro gcc Ala 130 gtt gtt Val Val 135 gac gca ctt cct Asp Ala Leu Pro t cg Ser 140 ctt atc gao gao Leu Ile Asp Asp ggc cag ctt cac Gly Gin Leu His 451 499 547 595 643 atc gcc gag ctg Ile Ala Giu Leu gtc gtc goa tat Val Val Ala Tyr ttg gca tac ccc Leu Ala Tyr Pro ggt gtg otc atc Gly Val Leu Ile gt t Val1 170 att oto too atc Ile Leu Ser Ile gc Al a 175 atc ttc agc tct Ile Phe Ser Ser gtg ttc Val Phe 180 aaa giG gao Lys Val Asp gaa ctc aaa Giu Leu Lys 200 aac aaa gaa gc Asn Lys Giu Ala gaa gog ggo gtt Giu Ala Gly Val gcg gtc cag Ala Val Gin 195 ott oca gc Leu Pro Ala ggc cgt cgc ato Gly Arg Arg Ile gtc acc gtc gct Val Thr Val Ala ga t Asp 210 ctg gag Leu Giu 215 aac ato cca gag Asn Ile Pro Giu otg Leu 220 cto aac oto cac Leu Asn Leu His att gtg too oga Ile Val Ser Arg 787 gtg gaa oga gao ggt gag caa tto ato ccg ott tat ggc gaa cac gca Val Giu Arg Asp Gly Giu Gin Phe Ile Pro Leu Tyr Gly Giu His Ala 235 240 cgc ate ggc gat Arg Ile Gly Asp tta aca gtg gtg Leu Thr VJal Val gcc gat gaa gaa Ala Asp Giu Glu etc aac Leu Asn 260 cgc gcg gaa Arg Ala Giu aat gtg gaa Asn Val Glu 280 gee atc ggt gaa AlaIle Gly Giu att gac ggc gac Ile Asp Gly Asp ccc tac agc Pro Tyr Ser 275 aca gca qtc Thr Ala Val ctt gat tac cga Leu Asp Tyr Arg cqc Arg 285 atc t tc gte tca Ile Phe Val Ser gtg ggc Val Gly 295 act ccc eta tcc Thr Pro Leu Ser etc cag cca etg Leu Gin Pro Leu ttt Phe 305 aaa gac atg ctg Lys Asp Met Leu atc Ile 310 acc cgc atc agg Thr Arg Ile Arq cqc Arg 315 ggc gac aca gat Gly Asp Thr Asp gtg gcc tee tcC Val Ala Ser Ser atg act ttg cag Met Thr Leu Gin ggt gac cgt gte Gly Asp Arg Val gtt gte gca eca Val Val Ala Pro gca gaa Ala Giu 340 aaa etc eqe Lys Leu Arg tee gat tte Ser Asp Phe 360 gaa Glu 345 gea ace caa ttg Ala Thr Gin Leu etc Leu 350 gge gat tee tac Gly Asp Ser Tyr aaq aaa etc Lys Lys Leu 355 ate ggt gtg Ile Gly Val 1027 1075 1123 1171 1219 1267 1315 1363 aac ctg etc eca Asn Leu Leu Pro etc Leu 365 get gee gge etc Ala Ala Gly Len ett gte Leu Val 375 gqc atg qtg gag Gly Met Val Gin ca eta eca ggt Pro Len Pro Gly gga Gly 385 age tee etg aaa Ser Ser Len Lys c tg Leu 390 ggt aae gca ggt Giy Asn Ala Gly gga Gly 395 ceg eta gtt gtt Pro Leu Val Val ctg etg etc gge Leu Len Len Gly ate aat ege aca Ile Asn Arg Thr aag tte gte tgg Lys Phe Val Trp ate ccc tac gga Ile Pro Tyr Gly gea aae Ala Asn 420 ett gee ett Leu Ala Leu ace tea geg Thr Ser Ala 440 eaa ctg gge ate Gin Leu Gly Ile eta ttt ttg get Leu Phe Leu Ala gee ate ggt Ala Ile Gly 435 ce caa tea Pro Gin Ser 1411 1459 ggc gea qga ttt Gly Ala Giy Phe ega Arg 445 tea geg ate aqe Ser Ala Ile Ser etc ace Len Thr 455 ate ate gge ttc Ile Ile Giy Phe geg ctg etc act Ala Leu Leu Thr ttg Le u 465 ttc ate tee ate Phe Ile Ser Ile 1507 1555 acg Thr 470 gtg ctg ttc gtt Val Len Phe Val gqc Gly 475 cac aaa ctg atg His Lys Leu Met aaa Lys 480 ate ccc tte ggt Ile Pro Phe Giy gaa Gin 485 ace get ggc ate ctc gee ggt aeg caa Thr Ala Gly Ile Leu Ala Gly Thr Gin 490 tat gtg tca gat gee tee cqc aae gag Tyr Val Ser Asp Ala Ser Arg Asn Glu 505 510 tct gtg tat ceg etg gcg atg ate gca Ser Val Tyr Pro Leu Ala Met Ile Ala 520 525 ttg ttg tte eta ctt atc tagcattgae Leu Leu Phe Leu Leu Ile 535 <210> 196 <211> 539 <212> PRT <213> Corynebaeterium glutamicum <400> 196 Val Ser Phe Leu Vai Giu Asn Gin Leu ace eac ect get gtg etg agt Thr His Pro Ala Val Leu Ser 495 500 etc ect gee atg ggt tat ace Leu Pro Ala Met Gly Tyr Thr 515 aag ate ctg gee gee caa aeg Lys Ile Leu Ala Ala Gin Thr 530 -ecttaageg eag 1603 1651 1699 1740 1 Thr Giy Pro Phe Met Ilie Asp Pro Thr 145 Leu Phe Gly Val1 Val1 Asp Val1 Lys Ala Al a Al a 130 Gly Ala Se r Val1 Gly Ala Ile Tyr Thr Thr Ala 115 Met Gin Tyr Ser Ala Le u Ala Ser Thr Thr Th r 100 Ser Ala Leu Pro Val1 180 Val1 5 Leu Val1 Val1 Ile Gly Al a Gly Al a His Leu 165 Phe Gin Leu Leu Pro Gly 70 Leu Leu Ala ValI Leu 150 Gly Lys Glu Gly Phe Ser 55 Leu Arg Ala Gly Val 135 Ile Val Val1 Leu Ile Gly Ile Al a Asn Al a 105 Leu Al a Glu Ile His 185 Gly Le u Lys Le u Tyr Gly Ala Leu Thr Leu Leu Val1 170 Asn Arg Ala Ile Al a Val1 Pro 75 Le u Ile Gly Pro Pro 155 Ile Lys Arg Leu Phe Leu Val1 Gly Thr Thr Al a Ser 140 Val1 Leu Glu Ile Val1 Gly Ser Gly Phe Leu ValI Le u 125 Leu Val1 Ser Ala Arg Met Le u Gi u Leu Ser Ile Ile Thr Asp Ser 160 Ile Ala Val1 Ala Val 225 Tyr Asp Gly Ser Phe 305 Val Val Ser Leu Gly 385 Leu Pro Leu Ser Leu 465 Ile Pro Ala Asp 210 Ile Gly Glu Asp Asn 290 Lys Ala Ala Tyr Met 370 Ser Leu Tyr Ala Asp 450 Phe Pro Ala Met 195 Leu Val Glu Glu Pro 275 Thr Asp Ser Pro Lys 355 Ile Ser Leu Gly Ala 435 Pro Ile Phe Val Gly 515 Pro Ser His Leu 260 Tyr Ala Met Ser Ala 340 Lys Gly Leu Gly Ala 420 Ile Gin Ser Gly Leu 500 Tyr Ala Arg Ala 245 Asn Ser Val Leu Asp 325 Glu Leu Val Lys Met 405 Asn Gly Ser Ile Glu 485 Ser Thr Glu 215 Glu Ile Ala Val Gly 295 Thr Thr Leu Asp Val 375 Gly Asn Ala Ser Thr 455 Val Ala Val Val 200 Asn Arg Gly Glu Glu 280 Thr Arg Leu Arg Phe 360 Gly Asn Arg Leu Ala 440 Ile Leu Gly Ser Tyr 520 Ile Asp Asp Lys 265 Leu Pro Ile Gin Glu 345 Asn Met Ala Thr Arg 425 Gly Ile Phe Ile Asp 505 Pro Pro Gly Val 250 Ala Asp Leu Arg Leu 330 Ala Leu Val Gly Gly 410 Gin Ala Gly Val Leu 490 Ala Leu Glu Glu 235 Leu Ile Tyr Ser Arg 315 Gly Thr Leu Glu Gly 395 Lys Leu Gly Phe Gly 475 Ala Ser Ala Leu 220 Gln Thr Gly Arg Lys 300 Gly Asp Gin Pro Phe 380 Pro Phe Gly Phe Gly 460 His Gly Arg Met 205 Leu Phe Val Glu Arg 285 Leu Asp Arg Leu Leu 365 Pro Leu Val Ile Arg 445 Ala Lys Thr Asn Ile 525 Asn Ile Val Leu 270 Ile Gin Thr Val Leu 350 Ala Leu Val Trp Thr 430 Ser Leu Leu Gin Glu 510 Ala Leu Pro Gly 255 Ile Phe Pro Asp Arg 335 Gly Ala Pro Val Gin 415 Leu Ala Leu Met Thr 495 Leu Lys His Leu 240 Ala Asp Val Leu Leu 320 Val Asp Gly Gly Ala 400 Ile Phe Ile Thr Lys 480 His Pro Ile Leu Ala Ala Gin Thr Leu Leu Phe Leu Leu Ile 530 535 <210> <211> <212> <213> <220> 197 1023 DNA Corynebacterium glutamicum <221> COS <222> (101)..(1000) <223> RXA02268 <400> 197 tgaatcgttg gtgcttcgag ttgggattgt tatgtgggga gacgtcgata agcaaaacac ttgccgagcg caagccggcc tacggcgcta gtgtgagcac atg tec cag gaa Met Ser Gin Glu 1 tct ggt ttg ttc Ser Gly Leu Phe cgc gcg att aca Arg Ala Ile Thr gqg gtg gct aag Gly Val Ala Lys gtg cgc Val Arg cgg aat ccg Arg Asn Pro cgc Arg gag gat ttt gcg Giu Asp Phe Ala gag Glu 30 qaa ttc acc caa Glu Phe Thr Gin gaa ctc tac Glu Leu Tyr ctg aag ccg Leu Lys Pro gat cac gca aca aat atc acc ctg Asp His Ala Thr Asn Ile Thr Leu ccc ctg acg gcg Pro Leu Thr Ala aat ggg Asn Gly ttt ttc cag gat Phe Phe Gin Asp ga t Asp tgg cgg gcg cga Trp Arg Ala Arg agt ggt gcg cga Ser Gly Ala Arg tgg ccg atc gtg Trp Pro Ile Val att cac gga tcc Ile His Gly Ser ggg gcc Gly Ala agc aag ggt Ser Lys Giy tca Se r tgg gag gaa atg Trp Glu Giu Met gct gag ctg cgc Ala Glu Leu Arg aaa ggt tgg gcc Lys Gly Trp Ala gtg ttt Val Phe 100 gcc cct qac Ala Pro Asp gcc caa att Ala Gin Ile 120 ttt Phe 105 qga acg cgt gcc Giy Thr Arg Ala acc Thr 110 gag oca att gcg Glu Pro Ile Ala gcg tcg gct Ala Ser Ala 115 acg ggc gct Thr Gly Ala 451 499 ggt geg tat att Gly Ala Tyr Ile gcc gtt ttg ttg Ala Val Leu Leu gcg cag Aia Gin 135 att gtg ctg gtt Ile Val Leu Val ggg Gly 140 cat tcg caa ggc His Ser Gin Gly gtc gtg gcg cgg Val Val Ala Arg tat Tyr 150 tgg atg cgc acc Trp Met Arg Thr ggc gga tac atg Gly Giy Tyr Met aag Lys 160 gtc agg cac atg Val Arg His Met att Ile 165 tcc atc tct acg cca aat cac gga acg Ser Ile Ser Thr Pro Asn His Gly Thr 170 ccg atg acg aag gtg aaa tcg gga gag Pro Met Thr Lys Val Lys Ser Gly Glu 185 190 cac aga cta ttc ggg ccc act ggt ttt His Arg Leu Phe Gly Pro Thr Gly Phe 200 205 atc atc gag ttt ttg gcc gac ggt ggg Ile Ile Giu Phe Leu Ala Asp Giy Gly 215 220 tac acc tgc att ggt acc cat ttt gat Tyr Thr Cys Ile Gly Thr His Phe Asp 230 235 gtg gcc ttt ttg gag gtc aac gag gac Val Ala Phe Leu Glu Val Asn Glu Asp 250 aat att tgg gtc gaa gat gaa cac ccg Asn Ile Trp Val Glu Asp Giu His Pro 265 270 gat atg gtg cgc gat ccc agg gtg atc Asp Met Val Arg Asp Pro Arg Val Ile 280 285 gac cgg gtg gca cgc ctc ggc taagttgc Asp Arg Val Ala Arg Leu Gly 295 300 <210> 198 <211> 300 <212> PRT <213> Corynebacterium giutamicum <400> 198 Met Ser Gin Giu Asn Ser Gly Leu Phe 1 5 Val Ala Lys Val Arg Arg Asn Pro Arg 25 Thr Gin Glu Leu Tyr Asp His Ala Thr 40 Ala Arg Leu Lys Pro Asn Gly Phe Phe 55 Pro Ser Gly Ala Arg Pro Trp Pro Ile 70 Ala Ser Lys Giy Ser Trp Glu Glu Met ctc Leu 175 gga Gly ga a Glu gac Asp cc t Pro gat Asp 255 cgc Arg gaa Giu atg gga Met Gly acg atc Thr Ile cag ctg Gin Leu ctc: gat Leu Asp 225 ttc atc Phe Ile 240 gat cca Asp Pro gca atg Ala Met atc gta Ile Val ggc att Gly Ile gaa aag Glu Lys 195 cgc gga Arg Gly 210 cca ggc Pro Giy caa cct Gin Pro aat cga Asn Arg att gcc Ile Ala 275 cgc gca Arg Ala tta Le u 180 ctg Le u cac His gtc Val1 ccg Pro gtc Val1 260 cac His gag Glu aac Asn atg Met ga c Asp acc Thr gag Glu 245 cac His aac: As n ct c Le u 643 691 739 787 835 883 931 979 1023 ;gg acatggttga cgc Lys Arg Ala Ile TI Giu Asp Phe Ala G. Asn Ile Thr Leu P. Gin Asp Asp Trp A. Val Leu Ile His G 75 Gly Ala Glu Leu A. hrr lu ro rg ly rg Gly Phe Thr Arg Gly Lys Gly Trp Ala Val Phe Ala Pro Asp Phe Gly Thr Arg Ala Thr Glu Pro 100 105 110 Ile Leu Gly 145 Val Gly Ile Leu Asp 225 Ile Pro Met Val Ala 115 Thr Val1 His Ile Lys 195 Gly Gly Pro Arg Al a 275 Ala Ser Gly Ala Met Leu 180 Leu His ValI Pro Val1 260 His Glu Al a Al a Tyr 150 Ser Pro His Ile Tyr 230 Val1 As n Asp Asp Ile 120 Ile Met Ser Thr Leu 200 Glu Cys Phe Trp Val1 280 Val1 Gly Val1 Arg Thr Lys 185 Phe Phe Ile Leu Val1 265 Arg Ala Ile Gly 140 Gly His Ser Thr Asp 220 His As n Gi u Arg Gly 300 Al a Ser Tyr Thr Glu 190 Phe Gly Asp Asp Pro 270 Ile Val1 Gin Met Leu 175 Gly Glu Asp Pro Asp 255 Arg Glu <210> 199 <211> 1095 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1072) <223> RXA02269 <400> 199 cgcaatgatt gcccacaacg atatqgtgcg cgatcccaqg gtgatcqaaa tcgtacgcgc 6b agagctcgac cgggtggcac gcctcggcta agttggggac atg gtt gac gcc ctc 115 Met Val Asp Ala Leu 1 aat gat ctc cgc cqa gaa ctc aca aac gcg tta agg tcc gtg tgg aaa 163 Asn Asp Leu Arg Arg Glu Leu Thr Asn Ala Leu Arg Ser Val Trp Lys 15 aac cte ec Asn Leu Pro gta gtg gaa Val Val Glu gat aac gee Asp Asn Ala ccg cag Pro Gin gcc gat gcc ttg Ala Asp Ala Leu cca gac gat Pro Asp Asp aaa aac cgc Lys Asn Arg gag att gcg ata Giu Ile Ala Ile aat As n 45 ttc tac cgt gat Phe Tyr Arg Asp ccc Pro ggc aaa Gly Lys ctc aac gaa gac Leu Asn Glu Asp aca gat tcc ttg Thr Asp Ser Leu atg ctc gcg cgc Met Leu Ala Arg cgt tea cgt gga Arg Ser Arq Gly ctt Leu ttt gaa gac Phe Glu Asp gat tgg Asp Trp 80 egc gcc cgc ccc Arg Ala Arg Pro ac Thr gaa qac cgc ccc Glu Asp Arg Pro eca gtg gta tta Pro Val Val Leu cac gqa act gqa His Gly Thr Gly tca aca Ser Thr 100 aaa ggt gat Lys Giy Asp gca gtg ttt Ala Val Phe 120 caa gac ttg gga Gin Asp Leu Giy gat cta cgc cgc Asp Leu Arg Arg gac ggc tgg Asp Gly Trp 115 tca gtc gca Ser Val Ala gca ccc gaa ttt Ala Pro Giu Phe ggc Gly 125 caa cgc gee ace Gin Arg Ala Thr gg t ci y 130 gaa tea Glu Ser 135 tcc gca caa att Ser Ala Gin Ile ggc Gly 140 gcc tat ata gat Ala Tyr Ile Asp gta ttg ctt gct Val Leu Leu Ala aca Thr 150 gga gcc tca aaa Gly Ala Ser Lys qtc Val1 155 att gtc gtt ggc Ile Val Val Gly cac His 160 tcc caa gge ggc Ser Gin Gly Gly gtg ValI 165 547 595 643 ttg ctg aga tac Leu Leu Arg Tyr tgg Trp 170 atg egt gtt ttg Met Arg Vai Leu gg t Gly 175 ggt gca tcc aaa Gly Ala Ser Lys gte aaa Val Lys 180 cac atg gte His Met Val ate gte agc Ile Val Ser 200 etc gct gtc c Leu Ala Val Pro cac ggc acc acc His Gly Thr Thr atg ggc gga Met Gly Gly 195 gtg gtt aat Val Val Asn ccg cta atc cgt Pro Leu Ile Arg aat egt ggc gaa Asn Arg Gly Giu agt Ser 210 tct gtc Ser Val 215 gtt caa tea tgg Val Gin Ser Trp ttc Phe 220 ggc gaa get gga Gly Giu Ala Gly gaa atg ate cgc Glu Met Ile Arg gga Gly 230 cac gac acc atc His Asp Thr Ile gee ate aat gaa Ala Ile Asn Giu ggc gat ttg gat Gly Asp Leu Asp gac gtg aca tat Asp Val Thr Tyr ct g Le u 250 tge ate gec ace Cys Ile Ala Thr ca c His 255 ttt gac ace gtg Phe Asp Thr Val att. cag Ile Gin 260 ccc cct gaa acc tgc ttc cta gag gcc cgg aac ccc gaa gaa ctc aag 931 Pro Pro Glu Thr Cys Phe Leu Glu Ala Arg Asn Pro Glu Glu Leu Lys 265 270 275 cgg gtc caa aac ate tgg gtg gaa aac ctc gac ccc aat tca gtc gtg 979 Arg Val Gin Asn Ile Trp Val Glu Asn Leu Asp Pro Asn Ser Val Val 280 285 290 ctc cac gaa gca atg cct tac gat ccc cgc gta cgc gca ctg gtc agg 1027 Leu His Glu Ala Met Pro Tyr Asp Pro Arg Val Arg Ala Leu Val Arg 295 300 305 gcg gat ttg agc aaa ttg gtg gag att tcc gag act gcg gag aac 1072 Ala Asp Leu Ser Lys Leu Val Glu Ile Ser Glu Thr Ala Glu Asn 310 315 320 taggggtttt ggtggttgtc taa 1095 <210> 200 <211> 324 <212> PRT <213> Corynebacterium glutamicum <400> 200 Met Val Asp Ala Leu Asn Asp Leu Arg Arg Glu Leu Thr Asn Ala Leu 1 5 10 Arg Ser Val Trp Lys Asn Leu Pro Thr Asp Asn Ala Pro Gin Ala Asp 25 Ala Leu Pro Asp Asp Val Val Glu Glu Ile Ala Ile Asn Phe Tyr Arg 40 Asp Pro Lys Asn Arg Gly Lys Leu Asn Glu Asp Lys Thr Asp Ser Leu 55 Pro Met Leu Ala Arg Ile Arg Ser Arg Gly Leu Phe Glu Asp Asp Trp 70 75 Arg Ala Arg Pro Thr Glu Asp Arg Pro Trp Pro Val Val Leu Val His 90 Gly Thr Gly Ser Thr Lys Gly Asp Trp Gin Asp Leu Gly Ala Asp Leu 100 105 110 Arg Arg Asp Gly Trp Ala Val Phe Ala Pro Glu Phe Gly Gin Arg Ala 115 120 125 Thr Gly Ser Val Ala Glu Ser Ser Ala Gin Ile Gly Ala Tyr Ile Asp 130 135 140 Thr Val Leu Leu Ala Thr Gly Ala Ser Lys Val Ile Val Val Gly His 145 150 155 160 Ser Gin Gly Gly Val Leu Leu Arg Tyr Trp Met Arg Val Leu Gly Gly 165 170 175 Ala Ser Lys Val Lys His Met Val Ser Leu Ala Val Pro Asn His Gly 180 185 190 1h r Glu Phe 225 Gi y Asp Pro Pro Arg 305 Th r Thr Ser 210 Glu Asp Thr Giu Asn 290 Ala Ala Met 195 Val1 Met Leu Val1 Gi u 275 Ser Leu Glu Gly Val1 Ile Asp Ile 260 Leu Val Val As n Gly As n Arg Pro 245 Gin Lys ValI Arq Ser 200 Val1 Asp Thr Giu Gin 280 Giu Leu Pro Gin Thr Tyr Thr 265 Asn Ala Ser Leu Ser Ile Leu 250 Cys Ile Met Lys Ile Trp Asn 235 Cys Phe Trp Pro Le u 315 Arg Phe 220 Ala Ile Leu Val1 Tyr 300 Val Gly Gly Gly 240 Phe Asn Asp Val1 Gi u 320 <210> 201 <211>. 1146 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1123) <223> RXA01614 <400> 201 tgcaattcgc aaacatgagt agtatcgcgg aagtttcacc tcgcgcacac cacaccaaca atcgacctat cgttatacgt t gg Trp ctc Leu cgc Arg gcq Al a aaa Lys ggC Gly tac: Tyr ttg Leu cca Pro gac Asp aac As n ctg Leu ga c Asp gac Asp cca Pro t gg Trp ttc Phe ccg Pro gac Asp gtt Val gga Gly aat Asn ca c His 45 ggc Gly gag Glu qa a Glu 30 qcq Al a atg Met ggC Gly 15 aca Thr qac Asp acg Thr tac Tyr gat Asp qag Glu gac Asp acgtgaacat ttcagtcgac atg aat cag atg cag Met Asn Gin Met Gin 1 caa aac ctc acc atc Gin Asn Leu Thr Ile gtt gtg aca acg gtt Val Val Thr Thr Val tct ttt gct gcc cqc Ser Phe Ala Ala Arg tac ttc ttc cac act Tyr Phe Phe His Thr gaa Glu ttc gcg gag ttt Phe Ala Glu Phe ttc Phe 75 cac aat gcc ggt His Asn Ala Gly ttt Phe gct gtg tac ggc Ala Val Tyr Gly gat ctt aga aaa Asp Leu Arg Lys gga cgc tcc tac Gly Arg Ser Tyr cca gga cag cag Pro Gly Gin Gin tgg cac Trp His 100 tac acc tct Tyr Thr Ser gag gtc atc Glu Val Ile 120 gat Asp 105 ctt gcc cat tac Leu Ala His Tyr cct gac tta aca Pro Asp Leu Thr gct gct gcc Ala Ala Ala 115 gec cat too Ala His Ser tct too acc cac Ser Ser Thr His ct Pro 125 gag cta gtc coo Glu Leu Val Pro act qgt Thr Gly 135 gga ctc atc gtt Gly Leu Ile Val ctq tgq atg tcc Leu Trp Met Ser cag Gin 145 atg cgc aca agc Met Arg Thr Ser aat As n 150 cca gct gcc att Pro Ala Ala Ile gag Giu 155 aag att cca gcg Lys Ile Pro Ala gtc ctc aac agt Val Leu Asn Ser cog Pro 165 tgg ctg gac atg Trp Leu Asp Met tat cca cca ctg Tyr Pro Pro Leu atc aag ctg atc Ile Lys Leu Ile acc cct Thr Pro 180 atg gtg agg Met Val Arg gga ggt ttg Gly Gly Leu 200 gtg Val1 185 ttg ggc aaa cgc Leu Gly Lys Arg ccc aca acc atc Pro Thr Thr Ile atc cca ggc Ile Pro Gly 195 ttt tac ggc Phe Tyr Gly gga gca tac gga Gly Ala Tyr Gly aaa Lys 205 tcg atc cat aag Ser Ile His Lys gaa tgg Giu Trp 215 gac ttt gac acc Asp Phe Asp Thr atc aag cot gta Ile Lys Pro Val gga cat aaa aag Gly His Lys Lys agc Ser 230 atc gga tgg ctt Ile Gly Trp Leu cgg Arg 235 gca gtc atg gct Ala Val. Met Ala ggc Gly 240 caa gca gaa atc Gin Ala Giu Ile cat His 245 cac gac cac gtg His Asp His Val gtc gga gtg gac Val Gly Val. Asp ctc acg otg tgt Leu Thr Leu~ Cys tca aat Ser Asn 260 aag tcc tgg Lys Ser Trp gog gtt ttg Ala Val Leu 280 ttg Leu 265 aag tct gaa tao Lys Ser Glu Tyr gag gac acc aac Giu Asp Thr Asn act tca gac Thr Ser Asp 275 cat ttg agc His Leu Ser 931 979 gat gtg aaa cac Asp Val Lys His att Ile 285 caa aag tqg gct Gin Lys Trp Ala tog cca Ser Pro 295 tog too agg gtt Ser Ser Arg Val. gtt gag ato ato Val Glu Ile Ile aac got cgc cac Asn Ala Arg His 1027 gat att tto oto tca agg aaa ccc goc aga gat cac goc tct gaa gta 17 1075 Asp Ile Phe Leu Ser Arg Lys Pro Ala Arg Asp His Ala Ser Glu Val 310 315 320 325 ctc aac aac tgg ctg caa tcg aag ctt tec agc etc aaa cca tct caa 1123 Leu Asn Asn Trp Leu Gin Ser Lys Leu Ser Ser Leu Lys Pro Ser Gin 330 335 340 taacaccgcg aattatagac tga 1146 <210> 202 <211> 341 <212> PRT <213> Corynebacterium glutamicum <400> 202 Met Asn Gin Met Gin Gin Trp Lys Pro Asp Phe Leu Gly Glu Gly Tyr 1 5 10 Gin Asn Leu Thr Ile Glu Leu Gly Asp Asp Pro Asp Asn Glu Thr Asp 25 Val Val Thr Thr Val Val Arg Tyr Asn Pro Asp Asn His Ala Asp Glu 40 Ser Phe Ala Ala Arg Pro Ala Leu Leu Trp Val His Gly Met Thr Asp 55 Tyr Phe Phe His Thr Glu Phe Ala Glu Phe Phe His Asn Ala Gly Phe 70 75 Ala Val Tyr Gly Ile Asp Leu Arg Lys Cys Gly Arg Ser Tyr Arg Pro 90 Gly Gin Gin Trp His Tyr Thr Ser Asp Leu Ala His Tyr Phe Pro Asp 100 105 110 Leu Thr Ala Ala Ala Glu Val Ile Ser Ser Thr His Pro Glu Leu Val 115 120 125 Pro Val Ala His Ser Thr Gly Gly Leu Ile Val Pro Leu Trp Met Ser 130 135 140 Gin Met Arg Thr Ser Asn Pro Ala Ala Ile Glu Lys Ile Pro Ala Leu 145 150 155 160 Val Leu Asn Ser Pro Trp Leu Asp Met Met Tyr Pro Pro Leu Phe Ile 165 170 175 Lys Leu Ile Thr Pro Met Val Arg Val Leu Gly Lys Arg Ser Pro Thr 180 185 190 Thr Ile Ile Pro Gly Gly Gly Leu Gly Ala Tyr Gly Lys Ser Ile His 195 200 205 Lys Asn Phe Tyr Gly Glu Trp Asp Phe Asp Thr Thr Ile Lys Pro Val 210 215 220 Glu Gly His Lys Lys Ser Ile Gly Trp Leu Arg Ala Val Met Ala Gly 225 230 235 240 Gin Thr Thr Ala Asp 305 His Leu Al a Le u Asn Pro 290 Asn Al a Lys Ile Ser 260 Ser Leu Arg Glu Ser 340 His Lys Al a Ser Asp 310 Leu Val1 Le u 265 Asp Ser Le u Trp Asn 250 Lys Val Arg Ser Leu 330 Gly Glu His Asp 300 Lys Ser Asp Thr 270 Gin Glu Ala Leu Val1 255 Giu Lys Ile Arg Ser 335 <210> 203 <211> 630 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (607) <223> RXA01983 <400> 203 atatcgctgc catggcagcc ttgctgggca acctcaagca cactgaccta gaagagctcc ccaccgatta ccaggggtgt cctcccatgt ccgctgcgtt atg gaa ggc tac acc Thr ggg Giy gca Al a cc Ala atg Met ctg Le u atc Ile aat Asn t cg Ser ccg Pro ggc Gly aco Thr aag Lys gog Al a gaa. Giu cat His ggt Gly ct t Leu ct C Leu acg Thr aac Asn cag Gin 60 gac Asp gtg Val1 ct. Pro oct Pro 30 ja c Asp gcg Al a atg Met gc t Al a Met 1 aca Thr ga t Asp ctg Leu gca Ala cog Pro ca g Gin Giu cag Gin ct C Leu cag Gin cg Pro gag Giu tco Se r Gly gtc ValI ctc Leu tac T yr ccc Pro caa Gin a cc Thr T yr aac Asn ggc Gly gca Al a ttc Phe tcg Se r otg Le u 115 163 211 259 307 355 403 ctc att Leu Ile gag ctg Glu Leu gag ggc Giu Gly 105 ggg cca Gly Pro 120 aca aat Thr Asn gga ctt Glv Leu ca g Gin 135 caq Gin ttt ggc cac ggt ttc ctc aat Phe Gly His Gly Phe Leu Asn 110 aac gtt cga cta gac aat ggt Asn Val Arg Leu Asp Asn Gly 125 ttc agc gcg cag cag agt ccg Phe Ser Ala Gin Gin Ser Pro 140 gcc qcc gac cat gag atg atc Ala Ala Asp His Giu Met Ile 155 160 taagactcta ccttcaccca act ccc Pro C9g Arg gga Gly 145 aag Lys ga a Giu 115 gag Glu ccc Pro ttt Phe 100 gtc gcg Val. Ala cgg gag Arg Glu ttt gaa Phe Glu ttc acc Phe Thr 165 451 499 547 595 cac ctt cgc His Leu Arg <210> 204 <211> 169 <212> PRT <213> Corynebacterium glutamicum <400> 204 Met Glu Gly 1 Thr Gin Val Asp Leu Leu Leu Gin Tyr Ala Pro Pro Pro Giu Gin Gin Ser Thr Pro Gly Giu 115 Arg Leu Giu 130 Gly Asn Pro 145 Lys Arg Phe Tyr As n Gly Al a Phe Ser Le u 100 Val1 Arg Ph e Phe Gly 5 Thr Gly Val1 Leu Ala Val1 Al a Giu Giu Thr 165 Pro Thr Gin Ile Gly Ala Ala 55 Met Leu Ile Le u Gin 135 Gin His As n Th r 40 Ser His His Giu Giy 120 Thr Gly Le u Giu 10 Pro Pro Val1 Thr His 90 Phe Asn Phe Ala Leu Thr As n Gin Asp Val1 His Arg Ala 140 Asp Leu Th r Tyr Asn Arg Gin Gly Leu 125 Gin His Pro Pro Asp Al a Met Ala Phe 110 Asp Gin Glu Ala Glu His Ala Val1 Gly Leu As n Se r Met <210> 205 <211> 1414 <212> DNA <213> Corynebacterium glutamioum <220> <221> CDS <222> (101)..(1414) <223> RXN02947 <400> 205 gtatgttoac acaagaaccc tgcacaacgo cttcaaagta cgtcgaocac gaccaagcgc attattcact ctcacccttc aggatttaga ctaagaaacc atg act gca gca Met Thr Ala Ala cag Gin aco aaa cct gac Thr Lys Pro Asp ctc Le u acc acc acg gct Thr Thr Thr Ala gga Gly 15 aag ctg tcc gat Lys Leu Ser Asp ctt cgc Leu Arg too cgt ctt Ser Arg Leu aaa gtg cac Lys Val His gaa got caa got Glu Ala Gin Ala atg ggc gaa gca Met Gly Glu Ala act gta gaa Thr Val Glu atc gag tat Ile Glu Tyr 211 259 got got ggc agg Ala Ala Gly Arg aag Lys 45 act goc cgo gaa Thr Ala Arg Glu cg t Arg ttg oto Leu Leu gat gag ggc tot Asp Glu Gly Ser gta gag atc gat Val Glu Ile Asp ott got cgt cao Leu Ala Arg His too aag aao ttc Ser Lys Asn Phe 9gc Gly otg gat 900 aag Leu Asp Ala Lys oca gtt act gao Pro Val Thr Asp ggt Gly gtt gtg aot ggt Val Val Thr Gly ggo aco ato gat Gly Thr Ile Asp ggo Gly ogt aag gto tgt Arg Lys Val Cys gtg tto Val Phe 100 307 355 403 451 499 too cag gao Ser Gin Asp gaa aag ato Giu Lys Ile 120 got qta tto ggt Ala Val Phe Gly got ttg ggt gaa Ala Leu Giy Glu gtt tat ggt Val Tyr Gly 115 ggt gtg oct Gly Val Pro gtt aag qtt atg Val Lys Val Met ga t Asp 125 ott gog atc aag Leu Ala Ile Lys aco Th r 130 ttg ato Leu Ile 135 gga ato aat gag Gly Ile Asn Giu got ggt gog ogt Ala Gly Ala Arg cag gaa ggt gtt Gin Glu Gly Val 547 595 gtg Val1 150 tot otg ggt otg Ser Leu Gly Leu tao Tyr 155 tca oag ato tto Ser Gin Ile Phe ogo aao aoc cag Arg Asn Thr Gin tot ggC gtt ato cca cag ato tot ttg ato atq ggt gcc tgo got ggt Ser Giy Val Ile Pro Gin Ile Ser Leu Ile Met Gly Ala Cys Ala Giy ggt cac gtg Gly His Val cag act tcc Gin Thr Ser 200 tcc cct gct ctg Ser Pro Ala Leu act Thr 190 gac ttc atc gtc Asp Phe Ile Val atg gtg gat Met Val Asp 195 aag act gtc Lys Thr Val 691 739 aag atg ttt atc Lys Met Phe Ile ggc cct gat gtc Gly Pro Asp Val acc ggt Thr Gly 215 gaa gat gtc acc Glu Asp Val. Thr ca g Gin 220 gag gag ctc ggt Glu GlU Leu Gly ggc gct cac acc Gly Ala His Thr 225 tct gat gat tca Ser Asp Asp Ser cac His ga t Asp 245 atg Met 230 gct acc tcc ggt Ala Thr Ser Gly tcc cat tac tct Ser His Tyr Ser 787 835 883 gct ttg gat tgg Ala Leu Asp Trp gt t Val1 250 cgc gag ctg acc Arg Glu Leu Thr t ct Ser 255 tat ctt cca tcc Tyr Leu Pro Ser aac aac Asn Asn 260 cgt gcg gaa Arg Ala Glu cag gaa aac Gin Giu Asn 280 cct cgc cag gag Pro Arg Gin Giu gac atc atg atc Asp Ile Met Ile ggt tcc atc Gly Ser Ile 275 atc atc ccg Ile Ile Pro atc aac gat gtg Ile Asn Asp Val ga t Asp 285 ctg gaa ttg gac Leu Giu Leu Asp acc Thr 290 gat tcc Asp Ser 295 ccg aac cag cct Pro Asn Gin Pro gac atg aag gaa Asp Met Lys Giu att tcc cgc atc Ile Ser Arg Ile gtc Val1 310 gac qac gcc gag Asp Asp Ala Giu ttc Phe 315 ttc gag atc cag Phe Glu Ile Gin gac tac gca gag Asp Tyr Ala Giu aac As n 325 1027 1075 1123 atc ctg tgt ggc Ile Leu Cys Gly ttc Phe 330 gct cgc gtt gag Ala Arg Vai Giu gtc Val1 335 cqt tct qtt ggc Arg Ser Val Gly atc gtg Ile Val 340 gct aac cag Ala Asn Gin gag aag gct Giu Lys Ala 360 acc cag ttc gct Thr Gin Phe Ala ggc Gly 350 tqc ttg gat att Cys Leu Asp Ile aag gca tct Lys Ala Ser 355 aac atc cca Asn Ile Pro 1171 1219 gcc cgt ttc atc Ala Arg Phe Ile acc tqc gat gcc Thr Cys Asp Ala ttc Phe 370 atc ctt Ile Leu 375 gag ttc gtg gac Glu Phe Vai Asp cca ggc ttc ctg Pro Giy Phe Leu ggc acc aac cag Giy Thr Asn Gin 1267 1315 ga a Giu 390 ttc gac ggc atc Phe Asp Gly Ile atc Ile 395 cgc cgc ggc gca Arg Arg Giy Ala aag Lys 400 ctg ctt tac gct Leu Leu Tyr Aia tac Tyr 405 gct gaa gca acc gtc ggc aag atc acc gtc atc acc cgc aag tcc tac Ala Giu Ala Thr Val Giy Lys Ile Thr Vai Ile Thr Arg Lys Ser Tyr 410 415 420 1363 ggc gga gcg tac tgc gtg atg ggt tcc aag gat atg ggc gct 99c ctg 1411 Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Asp Met Gly Ala Gly Leu 425 430 435 gta 1414 ValI <210> 206 <211> 438 <212> PRT <213> Corynebacterium glutamicum <400> 206 Met Thr Ala Ala Gln Thr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys 1 5 10 Leu Ser Asp Leu Arg Ser Arg Leu Ala Glu Ala Gin Ala Pro Met Gly 25 Giu Ala Thr Val Glu Lys Val his Ala Ala Gly Arq Lys Thr Ala Arg 40 Glu Ar Ilie Glu Tyr Leu Leu Asp Glu Gly Ser Phe Val Glu Ile Asp 55 Ala Leu Ala Arg His Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg 70 75 Pro Val Thr Asp Gly Val Val Thr Gly Tyr Gly Thr Ile Asp Gly Arg 90 Lys Val Cys Val Phe Ser Gin Asp Gly Ala Val Phe Gly Gly Ala Leu 100 105 110 Gly Giu Val Tyr Gly Giu Lys Ile Val Lys Val Met Asp Leu Ala Ile 115 120 125 Lys Thr Gly Val Pro Leu Ile Gly Ile Asn Glu Gly Ala Gly Ala Arg 130 135 140 Ile Gin Glu Gly Val Val Ser Leu Gly Leu Tyr Sdr Gin Ile Phe Tyr 145 150 155 160 Arg Asn Thr Gin Ala Ser Gly Val Ile Pro Gin Ile Ser Leu Ile Met 165 170 175 Gly Ala Cys Ala Gly Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe 180 185 190 Ile Val Met Val Asp Gin Thr Ser Lys Met Phe Ile Thr Gly Pro Asp 195 200 205 Val Ile Lys Thr Val Thr Gly Glu Asp Val Thr Gin Giu Giu Leu Gly 210 215 220 Gly Ala His Thr His Met Ala Thr Ser Gly Thr Ser His Tyr Ser Ala 225 230 235 240 Ser Asp Asp Ser Asp Ala Leu Asp Trp Val Arg Glu Leu Thr Ser Tyr 245 250 255 Leu Pro Ser Asn Asn Arg Ala Giu Thr Pro Arg Gin Giu Ala Asp Ile 260 265 270 Met Ile Gly Ser Ile Gin Glu Asn Ile Asn Asp Val Asp Leu Giu Leu 275 280 285 Asp Thr Ile Ile Pro Asp Ser Pro Asn Gin Pro Tyr Asp Met Lys Glu 290 295 300 Val Ile Ser Arg Ile Val Asp Asp Ala Giu Phe Phe Glu Ile Gin Giu 305 310 315 320 Asp Tyr Ala Giu Asn Ile Leu Cys Gly Phe Ala Arg Val Giu Val Arg 325 330 335 Ser Val Gly Ile Val Ala Asn Gin Pro Thr Gin Phe Aia Gly Cys Leu 340 345 350 Asp Ile Lys Ala Ser Giu Lys Ala Ala Arg Phe Ile Arg Thr Cys Asp 355 360 365 Ala Phe Asn Ile Pro Ile Leu Giu Phe Val Asp Val Pro Gly Phe Leu 370 375 380 Pro Giy Thr Asn Gin Giu Phe Asp Gly Ile Ile Arg Arg Gly Ala Lys 385 390 395 400 Leu Leu Tyr Ala Tyr Ala Giu Ala Thr Val Giy Lys Ile Thr Val Ile 405 410 415 Thr Arg Lys Ser Tyr Gly Gly Ala Tyr Cys Val Met Giy Ser Lys Asp 420 425 430 Met Gly Ala Gly Leu Val 435 <210> 207 <211> 686 <212> DNA <213> Corynebacterium giutamicum <22 0> <221> CDS <222> (688) <223> FRXA02320 <400> 207 qtatgttcac acaagaaccc tgcacaacgc cttcaaagta cgtcgaccac gaccaagcgc attattcact ctcacccttc aggatttaqa ctaaqaaacc: atg act gca gca cag 115 Met Thr Ala Ala Gin 1 aco aaa cct gac ctc acc: acc acg gct gqa aag ctg tcc gat ctt cgc 163 Thr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys Leu Ser Asp Leu Arg 15 tee cgt ctt gca gaa gct caa get cca atg ggc gaa gea. act gta gaa Ser Arg Leu Ala Giu Ala Gin Ala Pro Met Giy Glu Ala Thr Vai Glu 30 aaa Lys ttg Le u cgt Arg gtt Val1 tee Ser gaa Giu ttg Leu Val1 150 tet Ser ggt Gly gtg cac gct Vai His Ala ctc gat gag Leu Asp Giu tec aag aac Ser Lys Asn gtg act ggt Val Thr Gly cag gac qgc Gin Asp Gly 105 aag ate gtt Lys Ile Val 120 atc gga atc Ile Gly Ile 135 tet ctg ggt Ser Leu Gly ggc gtt ate Gly Val Ile eac'gtg tac His Val Tyr 1185 get Aila ggc Gly ttc Phe tac Tyr get Ala aag Lys aa t Asn ct g Leu eca Pro 170 tcc Ser ggc Gly tct Ser gge Gi y 75 gge Gly gta Val1 gt t Val gag Glu taG Tyr 155 cag Gin cct Pro agg Arg ttc Phe 60 ctg Leu ace Thr ttc Phe atg Met ggt Gly 140 tea Ser ate Ile get Ala act Thr gag Giu gee Ala gat Asp gge Gly 110 ctt Leu ggt Gly atc Ile t tg Leu act Thr 190 gee Ala ate Ile aag Lys gge Gly 95 get Ala 9gg Al a geg Al a ttc Phe ate Ile 175 ga e Asp c ge Arg gat Asp cgt Arg cgt Arg ttg Le u ate Ile cgt Arg tac Tyr 160 atg Met tte Phe gaa Giu get Ala ca Pro aag Lys ggt Gly aag Lys ate Ile 145 cgc Arg ggt Gly atc Ile ate Ile get Al a act Thr tgt Cys gtt Val1 115 ggt Gly ga a Glu ace Thr t ge Cys atq Met 195 gag Giu cgt Arg gae Asp gtg Val1 100 tat T yr gtg Val1 ggt Gly ca g Gin get Ala 180 gtg Val <210> 208 (211> 196 '212> PRT <213> Corynebacterium giutamicum <400> 208 Met Thr Ala Ala Gln Thr Lys Pro Asp Leu 1 5 10 Leu Ser Asp Leu Arg Ser Arg Leu Ala Glu 25 Giu Ala Thr Val Giu Lys Val His Ala Ala 40 Glu Arg Ile Giu Tyr Leu Leu Asp Glu Gly Thr Thr Thr Ala Gly Lys Ala Gin Ala Pro Met Gly Gly Arg Lys Thr Ala Arg Ser Phe Val Glu Ile Asp 55 Ala Leu Ala Arg His Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg 70 75 Pro Val Thr Asp Gly Val Val Thr Giy Tyr Gly Thr Ile Asp Gly Arg 90 Lys Val Cys Val Phe Ser Gin Asp Gly Ala Val Phe Gly Gly Ala Leu 100 105 110 Gly Giu Val Tyr Gly Glu Lys Ile Val Lys Val Met Asp Leu Ala Ile 115 120 125 Lys Thr Gly Val Pro Leu Ile Gly Ile Asn Giu Gly Ala Gly Ala Arg 130 135 140 Ile Gin Giu Gly Val Val Ser Leu Gly Leu Tyr Ser Gin le'Phe Tyr 145 150 155 160 Arg Asn Thr Gin Ala Ser Gly Val Ile Pro Gin Ile Ser Leu Ile Met 165 170 175 Gly Ala Cys Ala Gly Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe 180 185 190 Ile Val Met Val 195 <210> 209 <211> 519 <212> DNA <213> Corynebacterium glutamicum <220> <221> COS <222> (519) <223> FRXA02851 <400> 209 cct cqc cag aag gcc gac atc atg atc ggt too atc cag gaa aac atc 48 Pro Arg Gin Lys Ala Asp Ile Met Ile Gly Ser Ile Gin Glu Asn Ile 1 5 10 aac gat gtg gat ctg gaa ttg gao acc atc atc ccg gat too ccg aac 96 Asn Asp Val Asp Leu Giu Leu Asp Thr Ile Ile Pro Asp Ser Pro Asn 25 cag cct tat gao atg aag gaa gtt att tco cgc ato gtn gao gac gco 144 Gin Pro Tyr Asp Met Lys Giu Val Ile Ser Arg Ile Val Asp Asp Ala 40 gag ttc ttc gag atc cag gaa gac tao gca gag aac atc ctg tgt ggc 192 Giu Phe Phe Giu Ile Gin Giu Asp Tyr Ala Giu Asn Ile Leu Cys Gly 55 ttc got cgc gtt gag gnc cgt tnt gtt ggo ato qtg gct aac oag cca 240 Phe Ala Arg Val Glu Xaa Arg Xaa Val Gly Ile Val Ala Asn Gin Pro '70 75 acc cag ttc gct ggc tgn ttg gat att aag gca tct gag aag gct gcc 288 Thr Gin Phe Ala Gly Xaa Leu Asp Ile Lys Ala Ser Giu Lys Ala Ala 90 cgt ttc atc cgc acc tgc gat gcc ttc aac atc cca ate ctt gag ttc 336 Arg Phe Ile Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Leu Giu Phe 100 105 110 gtg gac gtt cca ggc ttc ctg cct ggc ace aac cag gaa ttc gac ggc 384 Val Asp Vai Pro Giy Phe Leu Pro Giy Thr Asn Gin Giu Phe Asp Gly 115 120 125 atc atc cgc cgc ggc gca aag etg ctt tac get tac get gaa gca acc 432 Ile Ile Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr Ala Glu Ala Thr 130 135 140 gtc gge aag ate acc gtc ate ace cgc aag tcc tac ggc gga gcg tac 480 Vai Gly Lys Ile Thr Val Ile Thr Arg Lys Ser Tyr Gly Giy Ala Tyr 145 150 155 160 tgc gtg atg ggt tee aag gat atg gqc get ggc ctg gta 519 Cys Val Met Gly Ser Lys Asp Met Gly Ala Gly Leu Val 165 170 <210> 210 <211> 173 <212> PRT <213> Corynebacterium giutamicum <400> 210 Pro Arg Gin Lys Ala Asp Ile Met Ile Gly Ser Ile Gin Giu Asn Ile 1 5 10 Asn Asp Val Asp Leu Giu Leu Asp Thr Ile Ile Pro Asp Ser Pro Asn 25 Gin Pro Tyr Asp Met Lys Glu Val Ile Ser Arg Ile Val Asp Asp Ala 40 Giu Phe Phe Glu Ile Gin Glu Asp Tyr Ala Giu Asn Ile Leu Cys Gly 55 Phe Ala Arg Val Glu Xaa Arg Xaa Val Gly Ile Val Ala Asn Gin Pro 70 75 Thr Gin Phe Ala Gly Xaa Leu Asp Ile Lys Ala Ser Glu Lys Ala Ala 90 Arg Phe Ile Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Leu Giu The 100 105 110 Val Asp Val Pro Gly Phe Leu Pro Gly Thr Asn Gin Giu Phe Asp Gly 115 120 125 Ile Ile Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr Ala Glu Ala Thr 130 135 140 Val Gly Lys Ile Thr Val Ile Thr Arg Lys Ser Tyr Gly Gly Ala Tyr 145 150 155 160 Cys Val Met Gly Ser Lys Asp Met Gly Ala Gly Leti Val 165 170 <210> 211 <211> 1752 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (1729) <223> RXN02321 <400> 211 tttaaaaact acccgcacgc agcacgaacc tgttcagtga tgtaaatcac cgcggaaata ttgtggacgt tacccccgcc taccgctacq atttcaaaac atg acc att tcc tca Met Thr Ile Ser Ser cct Pro aag Lys ggt Gly cgt Arg ga t Asp cgt Arg cgc Arg ctt Leu atc Ile cgt Arg 150 ttg Le u atc Ile gaa Glu gag Glu cag Gin cct Pro gaa Glu ggt Gly gac Asp 135 att Ile at t Ile qcc Al a aag Lys cgc Arg Ct g Leu gca Al a gtc Val1 gag Giu 120 acc Thr cag Gin gac Asp ga c Asp gca Al a t tg Leu gct Al a acc Thr tgC Cys 105 gtg Val1 Gly ga c Asp gt C Val1 ct t Leu gt a ValI ga t Asp CgC Arg gac Asp atc Ile tac Tyr cgc Arg ggc Gly gcc Ala aaq Lys gag Giu tac Tyr cac His 75 ggt Gly ttc Phe ggc Gly cca Pro gct Al a 155 aac Asn gct Ala aag Lys tta Le u 60 Cgc Arg atc Ile t cg Ser ga a Glu ttg Leu 140 gtc Val1 ct t Leu cgc Arg gtc Val1 45 ct C Le u acc Thr gtg ValI ca g Gin aa g Lys 125 at c Ile tcc Se r c ca Pro cgc Arg 30 cac His gat Asp acc Thr a cc Thr gac Asp 110 atq Met ggt Gly c tg Leu qac Asp 15 gcg Ala gc t Al a gag Glu gCt Al a ggc Gi y 95 ggc Gi y atc Ile ct t Leu ga c Asp atc Ile gaa Giu gc t Al a ggc Gly ttc Phe 80 tgg Trp acc Thr aag Lys tac Tyr ttC Phe 160 aac Asn gcc Ala gga Giy t cc Ser t gc C ys ggc Gly gta Vai atc Ile gaa Giu 145 a tt Ile acc Thr cat His cgc Arg ttC Ph e ct g Leu acc Thr ttc Phe atg Met 130 ggc Gly tcc Se r act Thr ttc Phe 35 ct c Leu atc Ile ggc Gly att I le ggt Gly 115 gag Glu gCt Al a cag Gin gcc Al a 20 ccc Pro act Thr gag Glu gct Ala ga t Asp 100 ggc Gly ctg Le u ggc Gi y acc Thr Gi y atg Met gcc Al a acc Thr aag Lys gga, Gi y gcg Ala gca Ala gct Al a ttc Phe 165 163 211 259 307 355 403 451 499 547 595 E-ac caa aae att Tyr Gin Asn Ile ca g Gin 170 gct tct ggc Ala Ser Gly gitt ate eca cag atc tee gtc atc 643 Val Ile 175 get tac Ala Tyr 190 Pro Gin Ile Ser Val Ile 180 atg gge gea Met Gly Ala ttc gtg gtc Phe Val Vai 200 gea ggt gge aac Ala Giy Gly Asn gge eca get Giy Pro Ala etg ace gac Leu Thr Asp 195 acc ggc cca Thr Gly Pro atg gtg gac aag Met Val Asp Lys ace Thr 205 tee aag atg tte Ser Lys Met Phe gao gtg Asp Val 215 ate aag ace gte Ile Lys Thr Vai ac Thr 220 gge gag gaa ate Gly Glu Giu Ile eag gaa gag ett Gin Giu Glu Leu gge Gly 230 gqa qea ace ace Gly Ala Thr Thr atg gtg ace get Met Val Thr Ala ggt Gly 240 aae tee eac tae Asn Ser His Tyr get gcg ace gat Ala Ala Thr Asp gag Gi u 250 gaa gca etg gat Glu Ala Leu Asp t gg T rp 255 gta eag gac etg Val Gin Asp Leu gtg tee Val Ser 260 tte etc eca ?he Leu Pro gag gaa gaa. Giu Giu Giu 280 .aac aat egc tee Asn Asn Arg Ser tac Tyr 270 gca ceg atg gaa Ala Pro Met Glu gae tte gac Asp Phe Asp 275 gat ctg aag Asp Leu Lys 931 979 ggc ggc qtt gaa Gly Gly Vai Giu gaa Giu 285 aae ate ace get Asn Ile Thr Ala gac Asp 290 etc gac Leu Asp 295 gag ate ate eca Giu Ile Ile Pro tec geg ace gtt Ser Ala Thr Val tac gac gte ege Tyr Asp Val Arg ga t Asp 310 gtc ate gaa tgc Val Ilie Glu Cys ace gac gat ggc Thr Asp Asp Gly gaa Giu 320 tae etg gaa ate Tyr Leu Giu Ile 1027 1075 1123 gea gac ege gca Ala Asp Arg Ala ga a Glu 330 aae gtt gtt att. Asn Val Val Ile tte gge ege ate Phe Gly Arg Ile gaa ggc Giu Gly 340 eag tee gtt Gin Ser Vai etg gac ate Leu Asp Ile 360 ggc Gi y 345 ttt gtt gee aae Phe Vai Ala Asn eag Gin 350 eca ace eag ttc Pro Thr Gin Phe get gge tge Ala Gly Cys 355 ege ace tge Arg Thr Cys gac tee tet gag Asp Ser Ser Giu gea get ege tte Ala Ala Arg Phe 1171 1219 1267 gac geg Asp Ala 375 tte aae ate eca Phe Asn Ile Pro gte atg ctt gte Val Met Leu Val gac gte eec gge tte Asp Val Pro Gly Phe 385 etg egt egt gge qea Leu Arg Arg Gly Ala eca gge gea gge Pro Gly Ala Giy eag Gin 395 gag tae ggt gqc Glu Tyr Gly Gly att Ile 400 aag etg etc tac gea tae gge gaa gca ace gtt cea aag ate ace gte 36 1363 Lys Leu Leu Tyr Ala Tyr Giy Glu Ala 410 Thr Val Pro Lys Ile Thr Val 415 420 acc Thr ggc Gly gtc Va1 atg Met 470 ttc Phe gaa Glu cag Gin atg Met ttg Leu atg Met 455 gca Ala gag Glu cgt Arg att Ile- aag Lys 425 tct Ser gct Ala gat Asp gag Glu ctg Leu 505 cgc Arg gct Ala gac Asp gct Ala gcc Ala tat Tyr 490 atc Ile aac Asn tac Tyr atc Ile ggC Gly aag Lys 475 gaa Glu gac Asp ctt Leu ggc Gly aac Asn gca Ala 460 ggc Gly gac Asp gCC Ala cgc Arg gga Gly ctt Leu 445 gtt Va1 ctc Leu cac His gtg Val ctg Leu 525 tac Tyr tgg Trp ttc Phe acc Thr ctc Leu 495 ctg Leu aag Lys gtq atg Val Met acc gca Thr Ala 450 tac cgc Tyr Arg 465 gct ctg Ala Leu ccg tac Pro Tyr agc gaa Ser Glu aag aac Lys Asn 530 ggt Gly 435 cag Gin aag Lys gct Ala cac His acc Thr 515 gtc Val aag Lys gcc Ala ctc Leu tcc Ser 485 gca Ala gga Gly cgc Arg 1411 1459 1507 1555 1603 1651 1699 cct qct cgc aag cac ggc aac atg Pro Ala Arg Lys His Gly Asn Met 535 540 ggt <210> 212 <211> 543 <212> PRT <213> Corynebacterium glutamicum <400> 212 Met Thr Ile Ser Ser Pro Leu Ile 1 5 Asn Thr Thr Ala Gly Lys Ile Ala Ala His Phe Pro Met Gly Giu Lys 40 Gly Arg Leu Thr Ala Arg Glu Arg 55 Ser Phe Ile Giu Thr Asp Gin Leu 70 Cys Leu Gly Ala Lys Arg Pro Ala cca ctg taaatcggcg aatccataaa Ero Leu 1749 1752 Asp Asp Ala Leu Ala rhr Va1 Leu Val Asp Arg Asp Ala Lys Glu Tyr His 75 Gly Asn Ala Lys Leu Arg Ile Leu Arg Va1 Leu Thr Val Ile Glu Ala Gly Phe Trp Gly Thr Ile Asp Giy Arg Giu Val Cys Ile Phe Ser Gin Asp Gly Thr 100 105 110 Val Phe Gly Gly Ala Leu Gly Giu Val Tyr Gly Glu Lys Met Ile Lys 115 120 125 Ile Met Giu Leu Ala Ile Asp Thr Gly Arq Pro Leu Ile Giy Leu Tyr 130 135 140 Glu Gly Ala Giy Ala Arg Ile Gin Asp Gly Ala Val Ser Leu Asp Phe 145 150 155 160 Ile Ser Gin Thr Phe Tyr Gin Asn Ile Gin Ala Ser Gly Val Ile Pro 165 170 175 Gin Ile Ser Val Ile Met Gly Ala Cys Ala Gly Gly Asn Ala Tyr Gly 180 185 190 Pro Ala Leu Thr Asp Phe Val Val Met Val Asp Lys Thr Ser Lys Met 195 200 205 Phe Val Thr Gly Pro Asp Val Ile Lys Thr Val Thr Gly Giu Giu Ile 210 215 220 Thr Gin Giu Giu Leu Gly Gly Ala Thr Thr His Met Val Thr Ala Gly 225 230 235 240 Asn Ser His Tyr Thr Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val 245 250 255 Gin Asp Leu Val Ser Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro 260 265 270 Met Glu Asp Phe Asp Glu Glu Glu Gly Gly Val Glu Glu Asn Ile Thr 275 280 285 Ala Asp Asp Leu Lys Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Vai 290 295 300 Pro Tyr Asp Val Arg Asp Val Ile Glu Cys Leu Thr Asp Asp Gly Giu 305 310 315 320 Tyr Leu Giu Ile Gin Ala Asp Arg Aia Giu Asn Val Val Ile Ala Phe 325 330 335 Gly Arg Ile Glu Gly Gin Ser Val Gly Phe Val Ala Asn Gin Pro Thr 340 345 350 Gin Phe Ala Gly Cys Leu Asp Ile Asp Ser Ser Giu Lys Ala Ala Arg 355 360 365 Phe Val Arg Thr Cys Asp Ala Phe Asn le Pro Ile Val Met Leu Val 370 375 380 Asp Val Pro Gly Phe Leu Pro Gly Ala Gly Gin Glu Tyr Gly Gly Ile 385 390 395 400 Leu Arg Arg Gly Aia Lys Leu Leu Tyr Ala Tyr Gly Glu Ala Thr Val 405 410 415 Pro Lys Ile Thr Val Thr Met Arg Lys Ala Tyr Gly Sly Ala Tyr Cys 420 425 430 Val Met Gly Ser Lys Gly Leu Sly Ser Asp Ile Asn Leu Ala Trp Pro 435 440 445 Thr Ala Gin Ile Ala Val Met Gly Ala Ala Gly Ala Val Gly Phe Ile 450 455 *460 Tyr Arg Lys Glu Leu Met Ala Ala Asp Ala Lys Gly Leu Asp Thr Val 465 470 475 480 Ala Leu Ala Lys Ser Phe Glu Arg Glu Tyr Glu Asp His Met Leu Asn 485 490 495 Pro Tyr His Ala Ala Giu Arg Sly Leu Ile Asp Ala Val Ile Leu Pro 500 505 510 Ser Giu Thr Arg Gly Gin Ile Ser Arg Asn Leu Arg Leu Leu Lys His 515 520 525 Lys Asn Val Thr Arg Pro Ala Arg Lys His Gly Asn Met Pro Leu 530 535 540 <210> 213 <211> 467 <212> DNA <213> Corynebacterium glutarnicum <220> <221> CDS <222> (444) <223> FRXA02321 <400> 213 gag tac ggt ggc att ctg cgt cgt ggc gca aag ctg ctc tac gca tcg 48 Giu Tyr Sly Sly Ile Leu Arg Arg Sly Ala Lys Leu Leu Tyr Ala Ser 1 5 10 qnn gaa gca ccg qtt cca aaq atc acc qtc acc atg cgt aag gct tac 96 Xaa Slu Ala Pro Val Pro Lys Ile Thr Val Thr Met Arg Lys Ala Tyr 25 ggc gga gcg tac tgc gtg atg ggt tcc aag ggc ttg ggc tct gac atc 144 Sly Gly Ala Tyr Cys Val Met Sly Ser Lys Sly Leu Sly Ser Asp Ile 40 aac ctt gca tgg cca acc gca cag atc gcc gte atg ggc gct get ggc 192 Asn Leu Ala Trp Pro Thr Ala Sin Ile Ala Val Met Sly Ala Ala Sly 55 gca gtt gga ttc atc tac cgc aag gag ctc atg gca gct gat gcc aag 240 Ala Val Sly Phe Ile Tyr Arg Lys Glu Leu Met Ala Ala Asp Ala Lys 70 75 ggc ctc gat ace gta get ctg get aag tcc ttc gag egc gag tat gaa 288 Sly Leu Asp Thr Val Ala Leu Ala Lys Ser Phe Slu Arq Slu Tyr Glu 90 gac cac atg ctc aac ccg tac cac gct gca gaa cqt gge ctg ate gac 336- Asp His Met Leu Asri Pro Tyr His Ala Ala Glu Arq Gly Leu Ile Asp 100 105 110 gcc qtg atc ctg cca agc gaa acc cgc gga cag att tcc cgc aac ctt Ala Val Ile Leu Pro Ser Giu Thr Arg Gly Gin Ile Ser Arg Asn Leu 115 120 125 cgc ctg ctc aag cac aag aac gtc act cgc cct gct cgc aag cac ggc Arg Leu Leu Lys His Lys Asn Val Thr Arg Pro Ala Arg Lys His Gly 130 135 140 aac atg cca ctg taaatcggcg aatccataaa ggt Asn Met Pro Leu 145 <210> 214 <211> 148 '212> PRT <213> Corynebacterium glutamicum <400> 214 Glu Xaa Gly As n Ala Gly Asp Ala Arg Asn 145 Tyr Gly Gly Ile Leu Arg Arg Gly Ala Lys Leu Leu Tyr Ala Ser Ala Ala Al a Giy Asp Met Ile 115 Le u Pro Pro Tyr Trp Phe Thr Le u 100 Leu Lys Leu Pro Val Thr Tyr 70 Ala Pro Ser Lys Lys Met Al a Arg Leu Tyr Giu Asn 135 Thr Ser Ile Glu Lys Ala 105 Arg Thr Val1 Lys Al a Leu Ser Ala Gly Arg Met Le u Met Al a Giu Arg Ile Al a 140 Arg Gly Gly Al a Arg Gly Ser 125 Arg Ala Asp Al a Ala Tyr Ile As n His Tyr Ile Gly Lys Giu Asp Le u Gi y <210> 215 c211> 514 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (514) <223> FRXA02343 tttaaaaact acccgcacgc agcacgaacc tgttcagtga ttgtggacgt tacccccgcc taccgctacg atttcaaaac tgtaaatcac cgcggaaata atg acc att tcc tca ill Met Thr Ile Ser Ser cct ttg att gac gtc gcc aac ctt cca Pro Leu Ile Asp Val Ala Asn Leu Pro atc aac acc act Ile Asn Thr Thr gcc ggc Ala Giy aag atc gcc Lys Ile Ala ggt gaa aag Gly Giu Lys ctt aag gct cgc Leu Lys Ala Arg cgc Arg gcg gaa gcc cat Ala Giu Ala His ttc ccc atg Phe Pro Met ctc act gcc Leu Thr Ala 211 259 gca gta gag aag Ala Val Glu Lys cac gct gct gga His Ala Ala Gly cgt gag Arq Glu cgc ttg gat tac Arg Leu Asp Tyr tta Le u ctc gat gag ggc Leu Asp Giu Gly ttc atc gag acc Phe Ile Glu Thr cag ctg gct cgc Gin Leu Ala Arg cgc acc acc gct Arg Thr Thr Ala ttc Phe tgc ctg ggc gct Cys Leu Gly Ala 307 355 403 cgt cct gca acc Arg Pro Ala Thr ggc atc gtg acc Gly Ile Val Thr tgg ggc acc att Trp Gly Thr Ile gat gga Asp Gly 100 cgc gaa gtc Arg Glu Val ctt ggt gag Leu Gly Giu 120 atc ttc tcg cag Ile Phe Ser Gin ga c Asp 110 ggc acc gta ttc Gly Thr Val Phe ggt ggc gcg Gly Gly Ala 115 gag ctg gca Giu Leu Ala gtg tac ggc gaa Val Tyr Gly Glu atg atc aag atc Met Ile Lys Ile atc gac a Ile Asp TI 135 <210> 216 <211> 138 <212> PRT cc ggc cgc hr Gly Arg <213> Corynebacterium giutamicum <400> 216 Met Thr Ile Ser Ser Pro Leu Ile Asp 1 5 Asn Thr Thr Ala Gly Lys Ile Ala Asp 25 Ala His Phe Pro Met Gly Giu Lys Ala Ala Asn Leu Pro Asp Ile Leu Lys Ala Arg Arg Ala Glu His Ala Ala Val Glu Lys Gly Arg Leu Thr Ala Arg Giu Arg Leu Asp Tyr Leu Leu Asp Giu Gly 55 Ser Phe Ilie Giu Thr Asp Gin Leu Ala Arg His Arg Thr Thr Ala Phe 70 75 Cys Leu Giy Ala Lys Arg Pro Ala Thr Asp Gly Ile Val Thr Gly Trp 90 Gly Thr Ile Asp Gly Arg Gin Vai Cys Ile Phe Ser Gin Asp Gly Thr 100 105 110 Val Phe Gly Gly Ala Leu Gly Gin Val Tyr Gly Glu Lys Met Ile Lys 115 120 125 Ile Met Giu Leu Ala Ile Asp Thr Gly Arg 130 135 <210> 217 (211> 4192 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (223> FRXA02850 <400> 217 gaa gag ctt ggc gga gca acc ace cac atg gtg ace gct ggt aac tcc 48 Glu Glu Leu Gly Gly Ala Thr Thr His Met Val Thr Ala Gly Asn Ser 1 5 10 cac tac ace get gcg ace gat gag gaa gca ctg gat tgg gta cag gac 96 His Tyr Thr Ala Ala Thr Asp Gin Giu Ala Leu Asp Trp Vai Gin Asp 25 etg gtg tcc tte etc cca tcc aae aat cgc tec tac gca ccg atg gaa 144 Len Val Ser Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro Met Glu 40 gac tte gac gag gaa gaa qgc ggc gtt gaa qaa aac ate acc gct gac 192 Asp Phe Asp Gin Gln Gin Gly Gly Val Gin Gin Asn Ile Thr Ala Asp 55 gat etg aag etc gae gag ate atc cca gat tee geg ace gtt ect tac 240 Asp Len Lys Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Val Pro Tyr 70 75 gac gte ege gat gte atn gaa tge etc ace gac gat ggc gaa tac etg 288 Asp Val Arg Asp Val Xaa Gin Cys Leu Thr Asp Asp Gly Gin Tyr Leu 90 gaa ate eag gca gnc ege gea gaa aac gtt gtt att gca ttc ggc ege 336 Gin Ilie Gin Aia Xaa Arg Ala Giu Asn Val Val Ile Ala Phe Gly Arg 100 105 110 ate gaa gge eag tee gtt gge ttt gtt gee aae cag eca ace eag ttc 384 Ile Gin Gly Gin Ser Val Gly Phe Vai Ala Asn Gin Pro Thr Gin Phe 115 120 125 gct ggo tgo ctg gac atc gao tcc tot gag aag gca gct ogc ttc gtc Ala Gly Cys Leu Asp Ile Asp Ser Ser Giu Lys Ala Ala Arg Phe Val 130 135 140 ogc aco tgo gac gog ttc aao atc coa ato gtc atg ctt gtg gac gtc Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Val Met Leu Val Asp Val 145 150 155 160 co ggc tto ctc Pro Gly The Leu <210> 218 <211> 164 <212> PRT <213> Gorynebaoterium glutamicum <400> 218 Glu His Leu Asp Asp Asp Giu Ile Al a Arg 145 Pro Giu Tyr Val1 Phe Leu Val1 Ile Glu Gly 130 Thr Gly Leu Thr Ser Asp Lys Arg Gin Gly 115 Cys Cys Phe Gly Ala Phe Glu Leu Asp Al a 100 Gin Leu Asp Leu Gly Aia Leu Glu Asp Val1 Xaa Ser Asp Al a Ala Thr Thr His Thr Pro Giu Giu 70 Xaa Arg Vali Ile Ph e 150 Giu As n 40 Gly Ile Cys Giu Phe 120 Se r Ile Glu 25 As n Val1 Pro Le u As n 105 Val1 Ser Pro Met Al a Arg Giu Asp Thr Val1 Al a Glu Ile Val1 Leu Ser Giu Se r Asp Val1 As n Lys Val1 155 Thr Asp Tyr As n Ala Asp Ile Gin Ala 140 Met Ala Trp Al a Ile Thr Giy Ala Pro 125 Al a Le u Gly Val1 Pro Thr Val1 Glu Phe 110 Thr Arg Val <210> 219 <211> 1671 <212> DNA <213> Corynebaoterium glutamioum <220> <221> CDS <222> (1648) <223> RXA02583 (400> 219 Cagttgtcga tgaaccagaa atcggoacag tcggagctca agatttotcg gaagaattag taacggagag ctgacggaag tttgagtcgc cgcattgatg ttg agt aac acc act ill Leu Ser Asn Thr Thr I act gca gag aag cta gcg Thr Ala Giu Lys Leu Ala 101 gat ctg cgc Asp Leu Arg cgc ctg gag att Arg Leu Giu Ile gcc aaa Ala Lys gao cca ggt Asp Pro Gly aco acc Oct Thr Thr Pro agt Ser gaa cgc gca cgt Glu Arg Ala Arg aaa Lys 30 aag cgc gac gag Lys Arg Asp Giu gaa ggo cga Giu Gly Arg gga tcc ttt Gly Ser Phe cgt cag cgt att Arg Gin Arg Ile got ctg ott gat Ala Leu Leu Asp gcc Al a gtg gag Val Giu ato ggc gca ota Ile Gly Ala Leu ggo Gly cgt aco cog gat Arg Thr Pro Asp ccc gat gcg cot Pro Asp Ala Pro tot gao ggt gtg Ser Asp Gly Val act ggt tat ggt Thr Gly Tyr Gly ato gat ggt cgc Ile Asp Gly Arg oca Pro gtg gcc atc tac Val Ala Ile Tyr gcc Al a cat gao aag acc His Asp Lys Thr gtt Val1 95 tac ggt ggt too Tyr Giy Giy Ser gtg ggc Val Gly 100 atg act tto Met Thr Phe att ggt tgc Ile Gly Cys 120 ogt aaa gtc ago Arg Lys Val Ser gto atg gao atg Val Met Asp Met gct atc ogo: Ala Ile Arg 115 gcc cgc ati Ala Arg Ile cca gtt atc ggt Pro Val Ile Gly att Ile 125 cag gat too ggo Gin Asp Ser Gly gga Gly 130 oag gat Gin Asp 135 gog gtg acc too Ala Val Thr Ser gog atg tao toa Ala Met Tyr Ser ato gog ogt ogt Ile Ala Arg Arg cag Gin 150 Ott cog ctg tot Leu Pro Leu Ser ogo ago oct oag Arg Ser Pro Gin too ato atg otg Ser Ile Met Leu ggt Gly 165 aaa tog goa ggt Lys Ser Ala Gly ggc Gi y 170 goa gtg tat gca Ala Val Tyr Ala oot Pro 175 gtg aco aot gao Val Thr Thr Asp ttt gtt Phe Val 180 ato ggc gtt Ile Gly Val ato aag gaa Ile Lys Giu 200 ggt gaa aca gaa Giy Giu Thr Glu atg Met 190 tat gto aco ggc Tyr Val Thr Gly cca gcc gtq Pro Ala Val 195 oto ggt ggo Leu Gly Giy gtc aoo ggo gag Vai Thr Gly Glu ato act too goa Ile Thr Ser Ala ggt gcg Gly Ala 215 cag cag atg caa Gin Gin Met Gin aac As n 220 ggc aac att tcc Giy Asn Ile Ser ttg gcg tcc tct Leu Ala Ser Ser gaa gag gcc ctg Giu Giu Ala Leu atg gtc aag gat Met Val Lys Asp ttg Leu 240 ctc gac ttc ctg Leu Asp Phe Leu cct Pro 245 ttg acc tgc aat Leu Thr Cys Asn ga t Asp 250 cca gcc cct gtg Pro Ala Pro Val gca gca cca acg Aia Ala Pro Thr gat gaa Asp Giu 260 gag atc gcc Giu Ile Ala aac cag ggc ASn Gin Gly 280 gac gaa gct ctg Asp Glu Ala Leu tcg ttc atg cct Ser Phe Met Pro gac gac act Asp Asp Thr 275 ttc gac gac Phe Asp Asp tac gac atg cat Tyr Asp Met His gac Asp 285 ctg ctg gac aag Leu Leu Asp Lys gcc aac Ala Asn 295 ctg ctg gaa atc Leu Leu Giu Ile qag gag tac qcc Glu Giu Tyr Ala aac ctg atc act Asn Leu Ile Thr 1027 1075 acc Thr 310 ttc gcc cgc gtt Phe Ala Arg Val gat Asp 315 ggc aag gca gtc Gly Lys Ala Val ggt Gly 320 gtg gtg gcc aac Val Val Ala Asn cca atg gat aag Pro Met Asp Lys gca ggc tgc atc qac gct gac gcc gcc gac aag ggc Ala Gly Cys Ile Asp Ala Asp Ala Ala Asp Lys Giy 330 335 340 gcc cgc ttc Ala Arg Phe gtc gtg gac Val Val Asp 360 cgt atc tqc gac Arg Ile cys Asp tac aac atc ccg Tyr Asn Ile Pro atc atc ttc Ile Ile Phe 355 gag aag gtc Giu Lys Val 1123 1171 1219 acc cct ggc tac Thr Pro Gly Tyr ctg Leu 365 cct ggc qtg gac Pro Gly Val Asp ggt ttg Gly Leu 375 att cac cqt ggc Ile His Arg Gly aag cta gcc ttc Lys Leu Ala Phe qtg qtg gaa tcg Val Val Giu Ser acc Thr 390 gtc cct sag att Val Pro Lys Ile t cc Ser 395 ttg atc gtq cgc Leu Ilie Val Arg aag Lys 400 gcc tac gc gga Ala Tyr Gly Gly 1267 1315 1363 tat gcc gtg atg Tyr Ala Val Met ggt Gly 410 tcc sag aac ctc Ser Lys Asn Leu qgt gac ctc sac Gly Asp Leu Asn ttc gca Phe Ala 420 tgg cca scc Trp Pro Thr atg atc cag Met Ile Gin 440 cag atc gcc gtg Gin Ile Ala Val ggc gca gcc gca Gly Ala Ala Ala gct gtc gtg Ala Val Val 435 cag cqt gaa Gin Arg Glu 1411 1459 ggc aag cag ctc Gly Lys Gin Leu gcc gcc cca cct Ala Ala Pro Pro tac aig aag aaa ctg tic atg qac ttc Tyr Met Lys Lys Leu Phe Met Asp Phe 455 460 cca tat gtg gcc gcc gag cgt ggt tac Pro Tyr Val Ala Ala Glu Arg Gly Tyr 470 475 gca -gag acc cgt ttg gtg ctt cgc cga Ala Glu Thr Arg Leu Val Leu Arg Arg 490 aaq gct gig cga gac cic gac aag aag Lys Ala Val. Arq Asp Leu Asp Lys Lys 505 510 taacgtccaa agaattatcc aga <210> 220 <211> 516 <212> PRT <213> Corynebacterium giutamicum <400> 220 Leu Ser Asn Thr Thr Thr Ala Glu Lys 1 Le u Asp Asp Glu Ile Gly Asp Gly Glu 145 Ser Glu Giu Ala Pro Asp Gly Met Gi y 130 Ile Ile Ile Glu Gly Asp Gly Ser Ala 115 Ala Al a Met Al a Gi y Ser Al a Arg Val1 100 Ile Ar g Arg Leu 5 Lys Arg Ph e Pro Pro Gly Arg Ile Arg Gly 165 Asp Thr Val1 T yr 70 Val Met Ile Gin Gin 150 Lys Pro Thr Glu 55 Ser Al a Thr Gly Asp 135 Leu Ser Ser 25 Arg Gi y Gly Tyr Gly 105 Pro Val1 Le u Gly tac T yr aic Ile g ca Ala 495 cac His Le u 10 Glu Gin Ala Val1 Ala 90 Arg Val1 Thr Se r Gly 170 Asp Ala Ile Gly Thr Asp Val1 Gi y Leu 140 Arg Val1 gat gag Asp Giu 465 gac gcc Asp Ala 480 giG cc Val Arg acg atc Thr Ile ca g Gin aig Met Leu Arg Asp Arg Gly Lys Ser Ile 125 Ala Ser T yr aac atg acc Asn Met Thr atg aic gaa Met Ile Giu agc Ser cct Pro 485 acc Th r 1507 1555 1603 ctg Leu ccg Pro 515 Arq Lys Ala Thr Tyr Thr Glu 110 Gin Met Pro Al a gaa Giu 500 atg Met Ala Lys Le u Pro Gly Val Val1 Asp T yr Gin Pro 175 Arg Ar g Le u Asp Arg Tyr Met Se r Se r Ile 160 Val1 1671 1648 Thr Thr Asp Val Ile Gly Val Gly Giu Thr Giu Met Tyr Val 190 Thr Gly Pro Ala Val Ile Lys Glu Val Thr Gly Glu Gin Ile Thr Ser 195 200 205 Ala Asp Leu Gly Gly Gly Ala Gin Gin Met Gin Asn Gly Asn Ile Ser 210 215 220 Tyr Leu Ala Ser Ser Glu Glu Glu Ala Leu Asn Met Val Lys Asp Leu 225 230 235 240 Leu Asp Phe Leu Pro Leu Thr Cys Asn Asp Pro Ala Pro Val Phe Ala 245 250 255 Ala Pro Thr Asp Glu Glu Ile Ala Tyr Asp Glu Ala Leu Asn Ser Phe 260 265 270 Met Pro Asp Asp Thr Asn Gin Gly Tyr Asp Met His Asp Leu Leu Asp 275 280 285 Lys Leu Phe Asp Asp Ala Asn Leu Leu Glu Ile Gin Glu Glu Tyr Ala 290 295 300 Pro Asn Leu Ile Thr Thr Phe Ala Arg Val Asp Gly Lys Ala Val Gly 305 310 315 320 Val Val Ala Asn Gin Pro Met Asp Lys Ala Gly Cys Ile Asp Ala Asp 325 330 335 Ala Ala Asp Lys Gly Ala Arg Phe Ile Arg Ile Cys Asp Ala Tyr Asn 340 345 350 Ile Pro Ile Ile Phe Val Val Asp Thr Pro Gly Tyr Leu Pro Gly Val 355 360 365 Asp Gin Glu Lys Val Gly Leu Ile His Arg Gly Ala Lys Leu Ala Phe 370 375 380 Ala Val Val Glu Ser Thr Val Pro Lys Ile Ser Leu Ile Val Arg Lys 385 390 395 400 Ala Tyr Gly Gly Ala Tyr Ala Val Met Gly Ser Lys Asn Leu Thr Gly 405 410 415 Asp Leu Asn Phe Ala Trp Pro Thr Ala Gin Ile Ala Val Met Gly Ala 420 425 430 Ala Ala Ala Val Val Met Ile Gin Gly Lys Gin Leu Glu Ala Ala Pro 435 440 445 Pro Glu Gin Arg Glu Tyr Met Lys Lys Leu Phe Met Asp Phe Tyr Asp 450 455 460 Glu Asn Met Thr Ser Pro Tyr Val Ala Ala Glu Arg Gly Tyr Ile Asp 465 470 475 480 Ala Met Ile Glu Pro Ala Glu Thr Arg Leu Val Leu Arg Arg Ala Val 485 490 495 Arg Gin Leu Glu Thr Lys Ala Val Arg Asp Leu Asp Lys Lys His Thr 500 505 510 Ile Met Pro Met 515 <210> 221 <211> 1635 <212> DNA <213> Corynebacterium giutamicum <220> <221> COS <222> (1612) <223> RXA00870 <400> 221 oaagacggcg atgtcgocgc cgctgttgat acogoagcgc gacttgttca cacagatatt caacaattca cttcgoagag catttaagga atttacacao atg tct gaa cca caa Met Ser Glu Pro Gin aco Thr aag Lys gtt Val acc Thr got Ala otg Leu atg Met ttc Phe att Ile a gc Ser 150 q ca atc Ile aco Thr g cg Al a a ag Lys gtg Val1 gog Aila ggt Gly cca Pro gat Asp 135 cg Pro atc tog Ser got Ala otg Le u got Ala ott Le u gag Glu gaa Glu oao His 120 gtq Val1 ttc Phe got oao His oct Pro got Al a got Ala tto Phe ato Ile ato Ile 105 ot g Leu tat Tyr aao As n goa t gg T rp gto Val ago Ser aag Lys aao Asn ato Ile otg Leu ott Leu too Ser tto Phe ggo gao Asp aat As n gaa Glu tgg Trp ogt Arg gca Ala qqc Gly ggt Gly aag Lys 140 gog Al a go a att too Ile Ser 15 act qqc Thr Gly gat gcc Asp Ala otg tot Leu Ser ctg aat Leu Asn 80 ggc aag Gly Lys gto gtg Val Val aac gag Asn Giu otg ggt Leu Gly cog atg Pro Met 160 ttg aag too Ser gto ValI ato Ile 50 got Ala ogo Arg t tg Leu ott Leu gto Val1 130 gto Val ttt Phe ggo Gly aa t Asn gc Ala oaa Gin gag Glu gc Ala ggt Gl y Gly ato Ile ato Ile cot tca gag aag gat Ala Ile Ala Ala Gly 170 Asn Ala Val Ile Leu 175 Lys Pro Ser Glu Lys Asp 180 cct tcg gca Pro Ser Ala cca gac gge Pro Asp Gly 200 ctg tgg atg get Leu Trp Met Ala atc tgg aag gaa Ile Trp Lys Giu gct ggt ctt Ala Gly Leu 195 get gtt gat Ala Val Asp 691 739 gta ttc aac gtg Val Phe Asn Val cag ggc gac aag Gln Gly Asp Lys ctg Leu 210 ggt ttg Gly Leu 215 etg aac age cct Leu Asn Ser Pro gat Asp 220 gte tct geg att Val Ser Ala Ile ttc gtg ggt tcc Phe Val Gly Ser cca ate gca aag Pro Ile Ala Lys t ac Tyr 235 ate tac gag act Ile Tyr Glu Thr gcg aag aac ggc Ala Lys Asn Gly 787 835 883 cgc gtc cag gcg Arg Val Gln Ala ttg Le u 250 qqc ggc gcg aag Gly Gly Ala Lys aac As n 255 cac atg ctg gtg His Met Leu Val ctg cca Leu Pro 260 gat get gat Asp Ala Asp ggc get gcc Gly Ala Ala 280 gat ctg gtt gee Asp Leu Val Ala eag qca ate aae Gln Ala Ile Asn gea ggt tae Ala Giy Tyr 275 ttg get att Leu Ala Ile 931 979 ggt gag egt tge Gly Glu Arg Cys atg Met 285 get gtt tct gtg Ala Val Ser Val gte Val1 290 gaa tct Glu Ser 295 gtt gee gac gag Val Ala Asp Giu etc Leu 300 att gag aag ate Ile Glu Lys Ile gag ege ate gae Giu Arg Ile Asp ace Thr 310 etg ege ate gge Leu Arg Ile Gly ggt gee gge gac Gly Ala Gly Asp eag gge gag eeg Gin Gly Glu Pro cae His 325 1027 1075 1123 etg gge eea eta Leu Gly Pro Leu ate Ile 330 ace gac gte eac Thr Asp Val His gac aag gte get Asp Lys Val Ala tct tat Ser Tyr 340 gte gac ate Val Asp Ile aae tge gee Asn Cys Ala 360 gag gee gae gge Glu Ala Asp Gly gee Ala 350 aag ate ate gtg Lys Ile Ile Val gac ggg egt Asp Gly Arg 355 gge ect aeg Gly Pro Thr 1171 1219 gta gac ggg eac Val Asp Gly His gag gge ttc tte Giu Gly Phe Phe tte Ph e 370 ett ate Leu Ile 375 gac gac ate eca Asp Asp Ile Pro etc Leu 380 aeg tte ege gee Thr Phe Arg Ala tac Tyr 385 ace gaa gaa ate Thr Giu Glu Ile 1267 1315 gge ceg gte etc Gly Pro Val Leu gte gtt egc gte Val Val Arg Val tee ttc gac gag Ser Phe Asp Glu gca Ala 405 att gag ctg ate aae tee ggt gaa tte gge aac gga ace gea ate ttc Ile Giu Leu Ile Asn Ser Gly Giu Phe Gly Asn Gly Thr Ala Ile Phe 1363 ac Thr ggc Gly t cc Se r ggc Gly 470 cg t Arg cag Gin aac Asn atg Met ttc Phe 455 act Thr tgg Trp aac As n 410 415 ggt gga gcg gca cgc cgc ttc Gly Giy Ala Ala Arg Arg Phe 425 430 ggc atc aac qta cca atc cca Gly Ile Asn Val Pro Ile Pro 445 ggt tgq aag aac tcc ctc ttc Gly Trp Lys Asn Ser Leu Phe 460 ggt ttt gat ttc ttc acc agg Gly Phe Asp Phe Phe Thr Arg 475 gac cca gca acc cac ggt ggc Asp Pro Ala Thr His Gly Gly 490 495 taattgaagg agagcacagg act cag Gin gtg Val1 ggt Gly gaa Giu 480 att Ile cat His cct Pro gac Asp 465 aag Lys aac As n gag Glu gt t Val1 450 gcc Ala gcg Ala ct c Le u atc Ile 435 g cg Ala aag Lys at c Ile ggt Gly 420 gaa gtg Giu Val tac cac Tyr His gca tat Ala Tyr acc ag c Thr Ser 485 ttc Cca Phe Pro 500 1411 1459 1507 1555 1603 1635 (210> 222 '<211> 504 <212> PRT <213> Corynebacterium glutamicum <400> 222 Met Ser Giu Pro Gin Thr Ile Ser His 1 5 Pro Ser Thr Ser Gly Lys Thr Ala Pro 25 Gin Vai Thr Ala Asn Val Ala Leu Ala Thr Ile Ala Ser Ala Thr Lys Ala Ala 55 Ile Ala Lys Arg Gin Ala Val Leu Phe 70 Ala Arg Lys Gly Glu Leu Ala Giu Ile Val Leu Ser Asp Ala Met Gly Giu Ile 100 105 Giu Leu Ala Thr Gly Phe Pro His Leu 115 120 Asn Val Ser Thr Gly Ile Asp Val Tyr 130 135 Val Val Gly Ile Ile Ser Pro Phe Asn Trp Val1 Se r Lys As n Ile Leu Leu Ser Phe Ile Tyr Gin Thr Ph e 75 Thr Arg Lys Le u Pro Asp As n Gi u Trp Arg Ala Gly Gly Lys 140 Al a Ala Ala Ile As n Leu His Giu 110 Phe Pro Val1 Se r Gly Al a Ser As n Lys Val1 Gi u Gly Met Phe Ser Glu Leu 210 Phe Lys Leu Asn Val 290 Glu Gly Val Val Phe 370 Thr Phe Thr Glu Val 450 Ala Phe Glu Ala 195 Ala Val Asn Val Ala 275 Leu Arg Glu Ala Asp 355 Gly Glu Asp Ala Ile 435 Ala Lys Pro Lys 180 Gly Val Gly Gly Leu 260 Gly Ala Ile Pro Ser 340 Gly Pro Glu Glu Ile 420 Glu Tyr Ala Ile 165 Asp Leu Asp Ser Lys 245 Pro Tyr Ile Asp His 325 Tyr Arg Thr Ile Ala 405 Phe Val His Tyr 150 Ala Pro Pro Gly Thr 230 Arg Asp Gly Glu Thr 310 Leu Val Asn Leu Phe 390. Ile Thr Gly Ser Gly 470 Ile Ser Asp Leu 215 Pro Val Ala Ala Ser 295 Leu Gly Asp Cys Ile 375 Gly Glu Asn Met Phe 455 Thr Ala Ala 185 Val Asn Ala Ala Leu 265 Gly Ala Ile Leu Ala 345 Val Asp Val Ile Gly 425 Gly Gly Gly Gly 170 Leu Phe Ser Lys Leu 250 Asp Glu Asp Gly Ile 330 Glu Asp Ile Leu Asn 410 Gly Ile Trp Phe 155 Asn Trp Asn Pro Tyr 235 Gly Leu Arg Glu Asn 315 Thr Ala Gly Pro Ser 395 Ser Ala Asn Lys Asp 475 Ala Met Val Asp 220 Ile Gly Val Cys Leu 300 Gly Asp Asp His Leu 380 Val Gly Ala Val Asn 460 Phe Val Ala Leu 205 Val Tyr Ala Ala Met 285 Ile Ala Val Gly Glu 365 Thr Val Glu Arg Pro 445 Ser Phe Ile Gin 190 Gin Ser Glu Lys Asp 270 Ala Glu Gly His Ala 350 Glu Phe Arg Phe Arg 430 Ile Leu Thr Leu 175 Ile Gly Ala Thr Asn 255 Gin Val Lys Asp Arg 335 Lys Gly Arg Val Gly 415 Phe Pro Phe Arg 160 Lys Trp Asp Ile Ser 240 His Ala Ser Ile Glu 320 Asp Ile Phe Ala Ala 400 Asn Gin Val Gly Glu 480 Lys Ala Ile Thr Ser Arg Trp Leu Asp Pro Ala Thr His Gly Gly Ile 485 490 495 Asn Leu Gly Phe Pro Gin Asn Asp 500 <210> C1 <211> <212> <213> 223 1305 DNA Corynebacterium C DS (1282) RXA01260 giutamicum <220> <221> <222> <223> '<400> 223 ctaaacgtqg qctgcattcc ttccaaagtc tctgatcaaa aacgctgaag ttgcccatac ctttacccat gagaag-aaga ccttcggcat caatggcgaa gtg acc ttc aac tat Val Thr Phe Asn Tyr gag gat gct cac Giu Asp Ala His cgt tcc cgt qgc Arq Ser Arg Gly tcc gac aaq atc Ser Asp Lys Ile gtt gga Val Gly ggc gtt cat Gly Val His ctt gga aac Leu Gly Asn tac Tyr ttg atg aag aag Leu Met Lys Lys aag atc atc gaa Lys Ile Ile Glu att cat ggt Ile His Gly gac ggt aag Asp Gly Lys ttc aag gat gct Phe Lys Asp Ala act ctt gag gtc Thr Leu Giu Val gat gct Asp Ala gqc aag acc atc Gly Lys Thr Ile ttt gat gac tgc Phe Asp Asp Cys atc Ile atc gca acc qgt Ile Ala Thr Gly t cg Ser gta gtc aac acc Val Val Asn Thr ctc Leu 75 cgt ggc gtt gac Arg Gly Val Asp tca gag aac gtt Ser Giu Asn Val gt g Val1 tct ttt gaa gag Ser Phe Giu Giu att ctt aac cct Ile Leu Asn Pro gcg cca aag aag Ala Pro Lys Lys atg gtc Met Vai 100 att gtt ggt Ile Val Gly aac tac qqt Asn Tyr Gly 120 qgc gca att gga Gly Ala Ile Gly atg Met 110 gaa ttc gcc tac Giu Phe Ala Tyr gtt ctt ggt Val Leu Gly 115 cgt qtq ctt Arq Val Leu 451 499 gta qat qta acc Val Asp Val Thr atc gag ttc atg Ile Giu Phe Met cca aat Pro Asn 135 gaa gat gct gaa Giu Asp Ala Giu tcc aag gtt att Ser Lys Val Ile gca Ala 145 aag gcc tac aag Lys Ala Tyr Lys aag Lys 150 atg ggc gtt aag Met Gly Val Lys ctt cct ggc cat Leu Pro Gly His acc act gct gtt Thr Thr Ala Val gac aac ggt gac Asp Asn Gly Asp ttt Phe 170 gtc gag gtt gat Val Glu Val Asp tac Tyr 175 cag aag aag ggc Gin Lys Lys Gly tct gac Ser Asp 180 aag aca gag C] Lys Thr Glu r cgt cca cgc Arg Pro Arg 200 ctt act gtt gat Leu Thr Val Asp gtc atg gtt tcc Val Met Val Ser gtt ggt ttc Val Giy Phe 195 gtt aag ctc Val Lys Leu 691 739 gtt gag gga ttt Val Giu Gly Phe ggt Gly 205 ctt gaa aac act Leu Glu Asn Thr g gc Gly 210 acc gag Thr Glu 215 cgt ggc gca atc Arg Gly Ala Ile atc gat gat tac Ile Asp Asp Tyr cgt acc aac gtc Arg Thr Asn Val gat Asp 230 ggc att tac gcc Gly Ile Tyr Ala atc Ile 235 ggt gac gtg acc Gly Asp Vai Thr aag ctt cag ctt Lys Leu Gin Leu gc t Aila 245 787 835 883 cac gtc gca gaa His Val Ala Giu cag ggc att gtt Gin Gly Ile Val gcc Ala 255 gca gag act att Ala Glu Thr Ile gct ggt Ala Gly 260 gca gaa act Ala Giu Thr ttc tgc aac Phe Cys Asn 280 act ctt ggt gat Thr Leu Gly Asp atg atg atg cca Met Met Met Pro cgt gca acc Arg Ala Thr 275 gag cag gcc Glu Gin Ala 931 979 cca cag gtt tct Pro Gin Val Ser tcc Se r 285 ttt ggt tac acc Phe Gly Tyr Thr gaa Giu 290 aag gag Lys Glu 295 aaq tgg cca gat Lys Trp Pro Asp gag atc aag gtt Giu Ile Lys Vai tcc ttc cca ttc Ser Phe Pro Phe t ct Ser 310 gca. aac ggt aaa Ala Asn Gly Lys gca Al a 315 gtt ggc ctq gca Val Gly Leu Ala act gat ggt ttc Thr Asp Gly Phe 1027 1075 1123 aag atc gtt gct Lys Ile Val Ala gca gaa ttc ggt Ala Giu Phe Gly gag Giu 335 ctg ctc ggt gca Leu Leu Gly Ala cac ctg His Leu 340 gtt gga qca Val Gly Ala aac tgg gat Asn Trp Asp 360 gca tca gag ctc Ala Ser Giu Leu aat gaa ttg qtg Asn Giu Leu Val ctt gct cag Leu Ala Gin 355 cat att cac His Ile His 1171 1219 ctc acc act gaa Leu Thr Thr Giu gag Glu 365 atc tct cgt agc Ile Ser Arg Ser gt c Val1 370 cca acg Pro Thr 375 cta tct gag gca, Leu Ser Giu Ala aag gaa gct gca Lys Giu Ala Ala ggt atc tct gga Gly Ile Ser Gly 1267 1305 cac atq atc aac ttc taqaatccac ctcgttggcc ctg His Met Ile Asn Phe 390 <210> 224 <211> 394 <212> PRT <213> Corynebacterium glutamicum <400> 224 Val Thr Phe Asn Tyr Glu Asp Ala His Lys Arg Ser Arg Gly Val Ser 1 5 10 Asp Lys Ile Val Gly Gly Val His Tyr Leu Met Lys Lys Asn Lys Ile 25 Ile Glu Ile His Gly Leu Gly Asn Phe Lys Asp Ala Lys Thr Leu Glu 40 Val Thr Asp Gly Lys Asp Ala Gly Lys Thr Ile Thr Phe Asp Asp Cys 55 Ile Ile Ala Thr Gly Ser Val Val Asn Thr Leu Arg Gly Val Asp Phe 70 75 Ser Glu Asn Val Val Ser Phe Glu Glu Gin Ile Leu Asn Pro Val Ala 90 Pro Lys Lys Met Val Ile Val Gly Ala Gly Ala Ile Gly Met Glu Phe 100 105 110 Ala Tyr Val Leu Gly Asn Tyr Gly Val Asp Val Thr Val Ile Glu Phe 115 120 125 Met Asp Arg Val Leu Pro Asn Glu Asp Ala Glu Val Ser Lys Val Ile 130 135 140 Ala Lys Ala Tyr Lys Lys Met Gly Val Lys Leu Leu Pro Gly His Ala 145 150 155 160 Thr Thr Ala Val Arg Asp Asn Gly Asp Phe Val Glu Val Asp Tyr Gin 165 170 175 Lys Lys Gly Ser Asp Lys Thr Glu Thr Leu Thr Val Asp Arg Val Met 180 185 190 Val Ser Val Gly Phe Arg Pro Arg Val Glu Gly Phe Gly Leu Glu Asn 195 200 205 Thr Gly Val Lys Leu Thr Glu Arg Gly Ala Ile Glu Ile Asp Asp Tyr 210 215 220 Met Arg Thr Asn Val Asp Gly Ile Tyr Ala Ile Gly Asp Val Thr Ala 225 230 235 240 Lys Leu Gin Leu Ala His Val Ala Glu Ala Gin Gly Ile Val Ala Ala 245 250 255 Glu Thr Ile Ala Gly Ala Glu Thr Gin Thr Leu Gly Asp Tyr Met Met 260 265 270 Met Pro Arg Ala Thr Phe Cys Asn Pro Gin Val 275 280 Thr Glu Giu Gin Ala Lys Glu Lys Trp Pro Asp 290 295 Ala Ser Phe Pro Phe Ser Ala Asn Gly Lys Ala 305 310 315 Thr Asp Gly Phe Ala Lys Ile Val Ala Asp Ala 325 330 Leu Gly Ala His Leu Val Gly Ala Asn Ala Ser 340 345 Leu Val Leu Ala Gin Asn Trp Asp Leu Thr Thr 355 360 Ser Val His Ile His Pro Thr Leu Ser Glu Ala 370 375 His Gly Ile Ser Gly His Met Ile Asn Phe 385 390 <210> 225 <211> 294 <212> DNA <213> Corynebacterium glutamicun <22 0> <221> CDS <222> (101)..(271) <223> RXA01261 <400> 225 gtgqgtgttt ttcattttct. tccactctaa aattaagtat atgcacgaca atgacccact aaacacgtat ccttgaatgc Ser 285 Giu Gl y Phe Leu Giu 365 Lys Giy Lys Ala Giu 335 Asn Ser Ala Tyr Val1 Giu 320 Le u Glu Arg Al a gac gta gta Asp Val Val cgt gca gcg Arg Ala Ala tgg qgt qqt Trp Giy Gly gat caa aaa Asp Gin Lys <210> 226 <211> 57 gt a Val1 cag Gin qtt Val1 cgc Arg ctc gga gcc ggc ccc ggt ggc Leu Gly Ala Gly Pro Gly Gly 15 ctt ggc aag aag gtt gct gta Leu Gly Lys Lys Val Ala Val 30 tqc cta aac gtg qqc tqc att Cys Leu Asn Val Gly Cys Ile 45 tgaagttgcc cataccttta ccc ggaaaaccaa ccgcacccgg gtg act gaa cat tat Val Thr Giu His Tyr 1 tat gtc tcc gcc atc Tyr Val Ser Ala Ile att gag aag cag tac Ile Glu Lys Gin Tyr cct tcc aaa gtc tct Pro Ser Lys Val Ser 115 163 211 259 <212> PRT (213> Corynebacteriun giutamicum <400> 226 Val Thr Glu His Tyr Asp Val Vai Val Leu Gly Ala Gly Pro Gly Gly 1. 5 10 Tyr Val Ser Ala Ile Arg Ala Ala Gin Leu Gly Lys Lys Val Ala Val 25 Ile Giu Lys Gin Tyr Trp Gly Gly Val Cys Leu Asn Val Gly Cys Ile 40 Pro Ser Lys Val Ser Asp Gin Lys Arg <210> 227 (211> 555 (212> DNA <213> Corynebacterium giutamicum <2 <221> CDS <222> (101)..(532) (223> RXA01136 <400> 227 ccctcgcaac accgacggta gcctcttgga aatggcgcgc atcgtgcgtg agctttcccg ctaggacctg tctactgcct tcactttgtg cgaacaccgc atq acc ttg Met Thr Leu gat tac Asp Tyr ttc Phe gaa Giu gag Glu ggt Gly gaa Glu cta Le u aag Lys ggg Gly ttt Ph e ggc Gly ga t Asp ctg Leu t cc Ser cqa Ar q ggt Gly aaa Lys qtg Val1 gca Ala ggc Gl y cgc Arg tgt Cys gt t Val1 at t Ile ttg Leu act Thr act Thr ggt Gly agt Ser gt g Val1 75 ggc Gly gct Ala acc Thr 30 gac Asp ctt Leu gca Ala acc Thr gga Gly atg Met gaa Giu tgg Trp acc Thr 80 ggt Gly 1 ttg Leu gcg Ala gca Ala gct Ala gca Ala gtc Val1 gct Ala agt Ser acc Thr t cc Ser gag Giu acc Thr gca Ala gca Ala 35 a gg Arq aac Asn gqc Gly ctc Leu gag Glu 20 ttc Phe gta Val ttg Leu tta Leu ggt Gly 100 tcg Ser aag Lys gaa Glu tgc Cys caa Gin tct Ser tca ctt gct cta ctc gqt ttg aac gca act gct tgc gct Ser Leu Ala Leu Leu Gly Leu Asn Ala Thr Ala Cys Ala tgg gtg agc Trp Val Ser 115 ttt gag gat gtc ttc att cci qqg gct cag att cta agc cac gat ttc 499 Phe Giu Asp Val Phe Ile Pro Gly Ala Gin Ile Leu Ser His Asp Phe 120 125 130 cit acc ttg tgg cat cgg tgc gcc caa cct tcg tgatcctacg gatctccgaa 552 Leu Thr Leu Trp His Arg Cys Ala Gin Pro Ser 135 140 <210> 228 <211> 144 <212> PRT <213> Corynebacterium giutarnicum <400> 228 Met Thr Leu Asp Tyr Phe Lys Ala Ser Gly Thr Asp Tyr Ala Leu Gly 1 5 10 Len Ala Ala Giu Ser Gin Gly Ala Arg Arq Thr Gly Ile Thr Gly Met 25 Ala Ser Ala Phe Lys Gin Phe Ala Gly Cys Gly Giu Ile Asp Leu Glu 40 Ala Thr Arg Val Glu Gly Gly Leu Lys Val Ser Gly Lys Leu Arg Trp 55 Ala Ser Asn Leu Cys Gin Asp Pro Vai Ile Val Pro Ala Ala Lys Thr 70 75 Ala Gin Gly Leu Gin Len Len Phe Ala Len Gly Ala Giu Thr Gin Gly 90 Val Thr Leu Gly Ser Ser Len Ala Len Len cGly Leu Asn Ala Thr Ala 100 105 110 Cys Ala Trp Val Ser Phe Giu Asp Val Phe Ile Pro Gly Ala Gin Ile 115 120 125 Leu Ser His Asp The Len Thr Leu Trp His Arg Cys Ala Gin Pro Ser 130 135 140 <210> 229 <211> 1140 <212> DNA <213> Corynebacterium qiniamicum <220> <221> CDS <222> (101)..(1117) <223> RXN00559 <400> 229 cccttcaatc cagictiga cggccaaiac ggcttgccgg gtttccagcg gatcaatcct Catgaagcat cagcctagta cgaaccgtta aagtgtccat atg tct gat aat ccg Met Ser Asp Asn Pro Cat gag aat ccc His Giu Asn Pro gag aat cca cac GJlu Asn Pro His tcc: cca gaa gtc Ser Pro Giu Val gtc ctt Val Leu 163 cgt ttc: atg Arg Phe Met gtt ggc: ggt Val Gly Gly qcc cct act gao: Ala Pro Thr Asp gtt Val ttg atg got ggt Leu Met Ala Gly agc cat ggc Ser His Gly gct tat gct Ala Tyr Ala ggc cga gtc ctg Gly Arg Val Leu tgg atc gat aag Trp Ile Asp Lys gct Ala acc cag tgq tct Thr Gin Trp Ser gga Gly aco tao tgt gtc Thr Tyr Cys Val gct tat gtt ggt Ala Tyr Val Giy att cac ttc act Ile His Phe Thr cct att coo tct Pro Ile Pro Ser ggc Ci y cac atg gtc gag His Met Vai Giu gt g Val1 cgt tcc cgc att Arg Ser Arg Ile atg act ggo cgt Met Thr Gly Arg tcc Ser tcc: atg cac atc Ser Met His Ile gtg aat Val Asn 100 gag gtg ott Glu Val Leu gac tgc ttg Asp Cys Leu 120 tot Ser 105 gog gat oct ogc: Ala Asp Pro Arg gat ggc aac tao acc cgt gcg tgt Asp Gly Asn Tyr Thr Arg Ala Cys 110 115 gtt att ttc: gtg Val Ile Phe Val gcg Al a 125 aag gao aoo gca Lys Asp Thr Ala ggt ogo got Gly Arg Ala aco oca Thr Pro 135 gtt cot tca ttt Val Pro Ser Phe cot aag aat gaa Pro Lys Asn Glu ga a Glu 145 gag cag ogo gtg Giu Gin Arg Val ttg Le u 150 gaa got gct aac Glu Ala Ala Asn cgc atc: ggg otg Arg Ile Gly Leu aag got att gaa Lys Ala Ile Giu gag atg gas aag Giu Met Glu Lys cag Gin 170 aog tao aao gga Thr Tyr Asn Gly ct Pro 175 tot gag goc cot Ser Glu Ala Pro cgt ttg Arg Leu 180 att aco ogo Ile Thr Arg gto cac ggt Val His Gly 200 ttg got aag oca Leu Ala Lys Pro aca Thr 190 gat ato aao tgg Asp Ile Asn Trp ggt ggc aag Gly Gly Lys 195 ggt gct gog Gly Ala Ala ggc act goc atg Gly Thr Ala Met tgg ato gat gag Trp Ile Asp Glu gog Ala 210 tgo aco: Cys Thr 215 atg gag tgg tot Met Giu Trp Ser gg t Gly 220 aao cac aco gtt Asn His Thr Val gtt tat got ggt Val Tyr Ala Gly ggt atc cgc ttc tac cag ccc att cag atc ggt gac ctc att gag gtg 835 Gly Ile Arg Phe Tyr Gin Pro Ile Gin Ile Gly Asp Leu Ile Glu Val 230 235 240 245 gac gcc cgc atg atg cgt ace gat aag cgt tcc atg cag atg tcc ate 883 Asp Ala Arg Met Met Arg Thr Asp Lys Arg Ser Met Gin Met Ser Ile 250 255 260 cac gtc cgt gcc ggt gat gct cac cgt ggc cgt gct gag cta gaa acc 931 His Val Arg Ala Gly Asp Ala His Arg Gly Arg Ala Glu Leu Glu Thr 265 270 275 gct att cac gca acg gtg acc tac tta gga att gat gtc gac gga gag 979 Ala Ile His Ala Thr Val Thr Tyr Leu Gly Ile Asp Val Asp Gly Glu 280 285 290 cct ttg cct gca cca cag ttt gtg cct cgt ace cct gag gat atc cag 1027 Pro Leu Pro Ala Pro Gin Phe Val Pro Arg Thr Pro Glu Asp Ile Gin 295 300 305 ttg gct gag cat gca aac atc ctg agg gat ctg cgt gct gat tac acc 1075 Leu Ala Glu His Ala Asn Ile Leu Arg Asp Leu Arg Ala Asp Tyr Thr 310 315 320 325 cca atg ccg ctg ttc cag cgc agg gtt cca ctg cag atc gac 1117 Pro Met Pro Leu Phe Gin Arg Arg Val Pro Leu Gin Ile Asp 330 335 tagttagacc cgaaaaagcc ccc 1140 <210> 230 <211> 339 <212> PRT <213> Corynebacterium glutamicum <400> 230 Met Ser Asp Asn Pro His Glu Asn Pro Arg Glu Asn Pro His Arg Ser 1 5 10 Pro Glu Val Val Leu Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met 25 Ala Gly Ser His Gly Val Gly Gly Gly Arg Val Leu Glu Trp Ile Asp 40 Lys Ala Ala Tyr Ala Cys Ala Thr Gin Trp Ser Gly Thr Tyr Cys Val 55 Thr Ala Tyr Val Gly His Ile His Phe Thr Arg Pro Ile Pro Ser Gly 70 75 His Met Val Glu Val Arg Ser Arg Ile Ala Met Thr Gly Arg Ser Ser 90 Met His Ile Val Asn Glu Val Leu Ser Ala Asp Pro Arg Asp Gly Asn 100 105 110 Tyr Thr Arg Ala Cys Asp Cys Leu Val Ile Phe Val Ala Lys Asp Thr 115 120 125 Ala Thr Gly Arg Ala Thr Pro Val Pro Ser Phe Thr Pro Lys Asn Giu 130 135 140 Glu Glu Gin Arg Val Leu Glu Ala Ala Asn Ser Arg Ile Gly Leu Arg 145 150 155 160 Lys Ala Ile Giu Ala Giu Met Glu Lys Gin Thr Tyr Asn Gly Pro Ser 165 170 175 Glu Ala Pro Arg Leu Ile Thr Arg Phe Leu Ala Lys Pro Thr Asp Ile 180 185 190 Asn Trp Gly Gly Lys Val His Gly Giy Thr Ala Met Glu Trp Ile Asp 195 200 205 Glu Ala Gly Ala Ala Cys Thr Met Glu Trp Ser Gly Asn His Thr Val 210 215 220 Ala Val Tyr Ala Gly Gly Ile Arg Phe Tyr Gin Pro Ile Gin Ile Gly 225 230 235 240 Asp Leu Ile Giu Val Asp Ala Arg Met Met Arg Thr Asp Lys Arg Ser 245 250 255 Met Gin Met Ser Ile His Vai Arg Ala Gly Asp Ala His Arg Gly Arg 260 265 270 Ala Giu Leu Glu Thr Ala Ile His Ala Thr Val Thr Tyr Leu Gly Ile 275 280 285 Asp Val Asp Gly Giu Pro Leu Pro Ala Pro Gin Phe Val Pro Arg Thr 290 295 300 Pro Giu Asp Ile Gin Leu Ala Giu His Ala Asn Ile Leu Arg Asp Leu 305 310 315 320 Arg Ala Asp Tyr Thr Pro Met Pro Leu Phe Gin Arg Arg Val Pro Leu 325 330 335 Gin Ile Asp <210> 231 <211> 313 <212> DNA <213> Corynebacteriun giutamicum <220> <221> CDS <222> (101)..(313) <223> FRXA00559 <400> 231 cccttcaatc cagtctttga cggccaatac ggcttgccgg gtttccagcg gatcaatcct catgaaqcat cagcctagta cgaaccgtta aagtgtccat atg tct gat aat ccg 115 Met Ser Asp Asn Pro 1 cat gag aat ccc cgt gag aat cca cac cgc tcc cca gaa gtc gtc ctt 163 His Glu Asn Pro GuAnPoHsA Glu Asn Pro His Arg 15 Ser Pro Glu Val Val Leu cgt ttc atg Arg Phe Met gtt ggc ggt Val Gly Gly cjcc cct act gac Ala Pro Thr Asp ttg atg gct ggt Ley Met Ala Gly agc cat ggc Ser His Gly gct tat gct Ala Tyr Ala ggc cga gtc ctg gaa tgg atc gat aag Gly Arg Val Leu Glu Trp Ile Asp Lys gct Ala tgt gct Cys Ala cac att His Ile acc cac ggg tct Thr His Gly Ser gga Gl y acc tac tgc gtc Thr Tyr Cys Val gct tat gtt ggt Ala Tyr Val Gly <210> 232 <211> 71 <212> PRT <213> Corynebacterium glutamicum (400> 232 Met Ser Asp Asn Pro 1 5 His Glu Asn Pro Glu Asn Pro His Arg Ser Pro Glu Val Ala Gly Ser Lys Ala Ala Leu Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met Trp Ile Asp His Gly Val Gly Gly Arq Val Leu Tyr Ala Cys Ala Thr His Gly Ser 55 Gly Thr Tyr Cys Val Thr Ala Tyr Val Gly His Ile <210> 233 <211> 802 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(802) <223> RXA01580 <400> 233 cggtaaacqc ctcattaaag tccaatgcca tqctcataac actaacaqtt aaccgtqcgg tcaactttgc tccctatcct taaaaagccc acagaaaagg atg tat aaq aat atg Met Tyr Lys Asn Met cac att gtt gcc cat cgc ggt gcg gaa gat ctg cac ctc gaa aac acc His Ile Val Ala His Arg Gly Ala Glu Asp Leu His Leu Glu Asn Thr atg aco got Met Thr Ala atc cac gcc Ile His Ala cag got gcc gcg Gin Ala Ala Ala got gac gct ttt Ala Asp Ala Phe gag otg gat Giu Leu ASP gac cgo ac Asp Arg Thr aco gct gac aat Thr Ala Asp Asn cag Gin 4.5 gtc gtc gtt ato Val Val Vai Ile cac His gca gog Ala Ala cgt gtt gcc gcg Arg Vai Ala Aia gat too ctg cac Asp Ser Leu His gao aoo oog gtt Asp Thr Pro Val gog Aia ogo tta ago goo Arg Leu Ser Ala oaa ato aag gag Gin Ile Lys Giu ata Ile aog ott ato gao Thr Leu Ile Asp too cco gta ooa Ser Pro Val Pro aco Thr otg gag gaa gtt Leu Giu Giu Val oto cag aog ago Leu Gin Thr Ser otg oog Leu Pro 100 atc oaa qtg Ile Gin Vai tta ttg oag Leu Leu Gin 120 qa a Gi u 105 ato aaa tot goo Ile Lys Ser Ala ggt Gly 110 goa gtt ooa goa Ala Val Pro Ala gcc goa gca Ala Aia Ala 115 ttc ato agt Phe Ile Ser aaa tao ooa gag Lys Tyr Pro Glu otq gag ogo otg Leu Giu Arg Leu otg Leu 130 ttc ato Phe Ile 135 gat goa gca otg Asp Ala Ala Leu gaa ato gtg gat Giu Ile Val Asp otg ooa gaa got Leu Pro Glu Ala ogc Arg 150 gtg gga ato ttg Val Gly Ilie Leu gat gog too atg Asp Ala Ser Met gat Asp 160 gat otg ogo att Asp Leu Arg Ile ott Le u 165 gat tao atc oog Asp Tyr Ile Pro ot a Leu 170 aaa ast gtg ggc Lys Asn Val Gly ato ttg ooo tog Ile Leu Pro Ser tgg aaa Trp Lys 180 gca ota aao Ala Leu Asn gtt ggo tgc Val Gly Cys 200 gtg Val1 185 gog toa att got Ala Ser Ile Ala ga t Asp 190 ota oat acc aag Leu His Thr Lys gga ato aag Gly Ile Lys 195 ato goa oaa Ile Ala Gin tgg aca att ogg Trp Thr Ile Arg ga t Asp 205 gaa aat gog ttt Glu Asn Ala Phe ggg Gly 210 oaa got Gin Ala 215 ggc gtt gat tao Gly Val Asp Tyr 000 aot gtt ago gat 000 Pro Thr Val Ser Asp Pro 220 225 tot ogt ttc tog Ser Arg Phe Ser oqo Arg 230 oct 000 otg otg Pro Pro Leu Leu <210> 234 <211> 234 <212> PRT <213> Corynebacterium glutamicum <400> 234 Met Tyr Lys Asn Met His Ile Val Ala His Arg Gly Ala Glu Asp Leu 1 5 10 His Leu Glu Asn Thr Met Thr Ala Phe Gin Ala Ala Ala Pro Ala Asp 25 Ala Phe Glu Leu Asp Ile His Ala Thr Ala Asp Asn Gin Val Val Val 40 Ile His Asp Arg Thr Ala Ala Arg Val Ala Ala Pro Asp Ser Leu His 55 Arg Asp Thr Pro Val Ala Arg Leu Ser Ala Ala Gin Ile Lys Glu Ile 70 75 Thr Leu Ile Asp Gly Ser Pro Val Pro Thr Leu Glu Glu Val Leu Leu 90 Gin Thr Ser Leu Pro Ile Gin Val Glu Ile Lys Ser Ala Gly Ala Val 100 105 110 Pro Ala Ala Ala Ala Leu Leu Gin Lys Tyr Pro Glu His Leu Glu Arg 115 120 125 Leu Leu Phe Ile Ser Phe Ile Asp Ala Ala Leu Val Glu Ile Val Asp 130 135 140 Arg Leu Pro Glu Ala Arg Val Gly Ile Leu Arg Asp Ala Ser Met Asp 145 150 155 160 Asp Leu Arg Ile Leu Asp Tyr Ile Pro Leu Lys Asn Val Gly Ala Ile 165 170 175 Leu Pro Ser Trp Lys Ala Leu Asn Val Ala Ser Ile Ala Asp Leu His 180 185 190 Thr Lys Gly Ile Lys Val Gly Cys Trp Thr Ile Arg Asp Glu Asn Ala 195 200 205 Phe Gly Ile Ala Gin Gin Ala Gly Val Asp Tyr Pro Thr Val Ser Asp 210 215 220 Pro Ser Arg Phe Ser Arg Pro Pro Leu Leu 225 230 <210> 235 <211> 882 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(859) <223> RXA02677 <400> 235 ttagtgcagt gtatttattt ccgttcacgc tgcggggctg gtggtttgga gggatactag aqtcgatagc aggtatataa aggccaggag agatgggttc aaa gtc atc Lys Val Ile cac cga ggt tta His Arg Gly Leu tct cgc ttt ccc Ser Arg Phe Pro gaa Glu tta aca gag tct Leu Thr Giu Ser gcg ttt Ala Phe cgg gcg gct Arg Ala Ala ctg act aaa Leu Thr Lys cta Leu gag cta ccg att Giu Leu Pro Ile gga att gaa act Gly Ile Giu Thr gat gtc cgg Asp Val Arg att gtg gat Ile Val Asp tgt ggc gaa gtg gtt aac gtc cat gac Cys Gly Glu Val Val Asn Val His Asp ccc Pro cgc gtg Arg Val tcg aat ggt cgc: Ser Asn Giy Arg ggt Gly c~g gtg tcg cqt Arg Val Ser Arg gac ttg gaa tcc Asp Leu Giu Ser 259 307 355 403 ttg Leu ctg agc: ttg aac Leu Ser Leu Asn gga acc aaa gaa Gly Thr Lys Glu cca gaa aaa gtg Pro Giu Lys Val ct t Le u act tta aac aat Thr Leu Asn Asn tta gat att ttt Leu Asp Ile Phe gag Giu gat tat cca gat Asp Tyr Pro Asp aag cac Lys His 100 ctt tat ata Leu Tyr Ile gaa gaa atc Giu Giu Ile 120 gaa Gl u 105 acc aag cac cca Thr Lys His Pro cgc tac gcg gtc Arg Tyr Ala Val atq ctg gaa Met Leu Glu 115 gaa gac cca Giu Asp Pro aca aaa atc tta Thr Lys Ile Leu tat cgt ggg ctg Tyr Arg Gly Leu cgc atc Arg Ile 135 cac atc att tct His Ile Ile Ser ttt Phe 140 gca ctt ccc gcg Ala Leu Pro Ala atg Met 145 tat cgc atg gct Tyr Arg Met Ala ctt gct cca cag Leu Ala Pro Gin gat cgc att cat Asp Arg Ile His ct g Leu 160 cgc agg tcg tgg Arg Arg Ser Trp cgt tgg ggt aat Arg Trp Gly Asn cgc: gat gtg cgc Arg Asp Val Arg tgc Cys 175 ggt gta ccc acc Gly Vai Pro Thr ggt ttg Giy Leu 180 ggg ttg tcg Gly Leu Ser aaa ggg tta Lys Gly Leu 200 ctg Leu 185 gag cgg gcg aag Giu Arg Aia Lys atg Met 190 gat cca agg atg Asp Pro Arg Met att ggg gcg Ile Gly Ala 195 aaa gac atg Lys Asp Met ccc acc tat ctt Pro Thr Tyr Leu acc gtc gat aag Thr Val Asp Lys ctg tgg Leu Trp 215 gcg cgc gaa cag Ala Arg Glu Gin ggc Gly 220 gtc gac atg ctc Val Asp Met Leu acc aat tat ccg Thr Asn Tyr Pro gac cgt gcg Asp Arg Ala 230 gct aat gcg Ala Asn Ala gag ctt ttg aac gca cat ccc aag ccc gcc atg tac Glu Leu Leu Asn Ala His Pro Lys Pro Ala Met Tyr 235 240 245 ggc aaa gaa gac taagaagaat gaacagctgc cgg Gly Lys Glu Asp 250 <210> 236 <211> 253 <212> PRT <213> Corynebacterium glutamicum <400> 236 Met Thr Glu Asp Leu Pro T yr Ala Leu Met 145 Arq Val1 Arg Lys Ala 225 Lys Giu Thr Pro Asp Gi u Pro Val1 Thr 130 T yr Arg Pro Met Gin 210 Th r Val1 Ser Asp Ile Leu Lys Asp Met 115 Giu Arg Ser Thr Ile 195 Lys Asn Ala His Arg Phe Arg Ala Arg Leu Thr Asp Arg Val 55 Ser Leu Leu 70 Leu Thr Leu His Leu Tyr Giu Glu Glu Pro Arg Ile 135 Ala Arg Leu 150 Glu Arg Trp 165 Leu Gly Leu Ala Lys Gly Met Leu Trp 215 Pro Asp Arg 230 Giy Leu Ser 10 Ala Leu Giu Lys Cys Gly 40 Ser Asn Gly Ser Leu Asn Asn Asn Leu 90 Ile Giu Thr 105 Ile Thr Lys 120 His Ile Ile Ala Pro Gin Gly Asn Pro 170 Ser Leu Glu 185 Leu Pro Thr 200 Ala Arg Giu Ala Ala Giu Arg Pro Val1 Gly Gi y Asp His Leu Phe 140 Asp Asp Al a Leu Gi y 220 Leu Phe Ile Val1 Arg Thr Ile Pro Lys 125 Al a Arq Val1 Lys Phe 205 Val1 Asn Pro His As n Val1 Lys Phe Met 110 Tyr Le u Ile Arg Met 190 Thr Asp Al a Glu Gly Val Ser Glu Glu Arg Arg Pro His Cys 175 Asp Val Met His Le u Ile His Arg Thr Asp T yr Gi y Ala Le u 160 Gly Pro Asp Le u Pro 240 Lys Pro Ala Met Tyr Ala Asn Ala His Gly Lys Glu Asp 245 250 <210> <211> <212> <213> <220> <221> <222> <223> 237 1428 DNA Corynebacterium CDS (101) (14 RXSoil166 glutamicum <400> 237 accgtaccca cagacacacc agaattaaca gaaacaqact gaaaaacaac: atcgctcgac atgcgcgtaa tcctaacccg cgcacactaa tgtggccgat atq ggc tac acc Met Gly Tyr Thr 1 ctc aac gac aca Leu Asn Asp Thr gtc ttg cgc gcc Val Leu Arg Ala tca tgt gat 9CC Ser Cys Asp Ala tgg tgg Trp Trp cgc acg atg Arg Thr Met cgc atc atg Arg Ile Met ccg cta gtg cag Pro Leu Val Gin gga agt gag gca Gly Ser Glu Ala qtC ttt cg Val Phe Arg ggc ttt gac Gly Phe Asp ggt ctc tcg cgg Gly Leu Ser Arg cgt Arg 45 cct gat cgg aaa Pro Asp Arg Lys cct Pro gat gtc Asp Val cca cat ttc ggc Pro His Phe Gly gct gtt oga gtt Ala Val Arg Val ccc Pro ggt cta aaa cac Gly Leu Lys His ggc Gly gag Giu acg ttg gtc aat Thr Leu Val Asn CCC aac ccc qcg Pro Asn Pro Ala gct Al a 75 gca ccc ttg aaa Ala Pro Leu Lys gt t Val 80 ttg ggc gca cgg Leu Gly Ala Arq ggc Gly agt tcg tac Cqt Ser Ser Tyr Arg qaa tac atc aco Giu Tyr Ile Thr ggt gat Gly Asp 100 tcc gca ggt Ser Ala Gly cgc ccc tgg Arg Pro Trp 120 gcc atc act gcg Ala Ile Thr Ala ggc gct gtC ctc Gly Ala Val Leu ttt tcc aca Phe Ser Thr 115 gct cca tcc Ala Pro Ser aca acc ggc ccg Thr Thr Gly Pro cgt Arg 125 ccc gcg atc gcc Pro Ala Ile Ala atq Met 130 ace caa Thr Gin 135 ggc gtc gca cag Gly Vai Ala Gin tgc gat ccc tcc cac acc tgc gcc atc Cys Asp Pro Ser His Thr Cys Ala Ile 145 gga Giy 150 etc aac gca ttc Leu Asn Ala Phe tat T yr 155 gac aaa ccc ttc Asp Lys Pro Phe gca ate att get Ala Ile Ile Ala gaa ctc ccc gtc Glu Leu Pro Val atc Ile 170 ctc tgg ttt cta Leu Trp Phe Leu gct Al a 175 080 gga ctt gac His Gly Leu Asp gtt gtg Val Val 180 k 4 ttc atc gat fl Phe Ile Asp ~~gat tcc atc C1 Asp Ser Ile 200 ccc cgc gac ccc Pro Arg Asp Pro acc ggc gtc caa Thr Gly Val Gin tac tat tgc Tyr Tyr Cys 195 ctc gcc tcc Leu Ala Ser 691 739 gct gca gct aaa Ala Ala Ala Lys tcg Ser 205 ctt ctc gac gcc Leu Leu Asp Ala gtc Val 210 aga caa Arg Gin 215 ctc ggc ctt tca Leu Gly Leu Ser gaa gca ccg ctt Glu Ala Pro Leu ggc Gly 225 ctg tgq gga ttc Leu Trp Gly Phe caa gqa ggc ggc Gin Gly Gly Gly act ggc tgg qct Thr Gly Trp Ala gca Ala 240 caa ttg cag gat Gin Leu Gin Asp tac Tyr 245 gca cct gat gtc Ala Pro Asp Val cgc Arg 250 cca aaq gca gcg Pro Lys Ala Ala gtg ggc gct cca Val Gly Ala Pro cca gtg Pro Val 260 gat ctc ttc Asp Leu Phe gtg att gcc Val Ile Ala 280 gtc ttg gac act Val Leu Asp Thr gac ggc gga ttg Asp Gly Gly Leu ctc acc gga Leu Thr Gly 275 tca gag atg Ser Glu Met tac qcc ato qcg Tyr Ala Ile Ala gga Gly 285 ctt gca gtg aac Leu Ala Val Asn t ct Ser 290 ttt gag Phe Glu 295 gaa atc atg tcg Glu Ile Met Ser tta aat qaa cgc Leu Asn Giu Arg gga Gly 305 gtc agt gat gtg Val Ser Asp Val aaa aat atc acc Lys Asn Ile Thr tgc gcg gga ggt Cys Ala Gly Gly ttg ttg gcc agt Leu Leu Ala Ser ggc Gi y 325 tac tcg tct tcc Tyr Ser Ser Ser cgc Arg 330 ggg tgg aca cat Gly Trp Thr His cag Gin 335 ggc acg ccg ctg Gly Thr Pro Leu gca gao Ala Asp 340 1027 1075 1123 1171 1219 att ctg gac Ile Leu Asp ctg ggt cgt Leu Gly Arq 360 ctg cca ctt gtt Leu Pro Leu Val gct gag ttt ggg Ala Glu Phe Gly aag caa aag Lys Gin Lys 355 ggc tct aaa Gly Ser Lys gtg gcg cca gaa Val Ala Pro Glu cca gtg ctg ttg Pro Val Leu Leu aat gat Asn Asp 375 gat gtc att ccc Asp Val Ile Pro att Ile 380 gat ccc att agg Asp Pro Ile Arg ga a Glu 385 ttg cgt gat agc Leu Arg Asp Ser 1267 1315 tgg T rp 390 gcg gac aag ggt Ala Asp Lys Gly cca ttg acc tgg Pro Leu Thr Trp gaa tcc caa gcg Glu Ser Gin Ala cgt gtg cca gga cgc aca ggt ctc aac cat ttc ggg ccc tat ttt aga 16 1363 Arg Val Pro Gly Arg Thr Gly Leu Asn His Phe Gly Pro Tyr Phe Arg 410 415 420 aac ctg gaa aag tac tcg gga tgg ctc ata gat cat ctt gtc 1405 Asn Leu Glu Lys Tyr Ser Gly Trp Leu Ile Asp His Leu Val 425 430 435 tgagtgccgt tttaaaggct cgg 1428 <210> 238 <211> 435 <212> PRT <213> Corynebacterium glutamicum <400> 238 Met Gly Tyr Thr Asn Leu Asn Asp Thr Arg Val Leu Arg Ala Gly Ser 1 5 10 Cys Asp Ala Trp Trp Arg Thr Met Ser Pro Leu Val Gin Gin Gly Ser 25 Glu Ala Val Phe Arg Arg Ile Met Gly Leu Ser Arg Arg Pro Asp Arg 40 Lys Pro Gly Phe Asp Asp Val Pro His Phe Gly Ala Ala Val Arg Val 55 Pro Gly Leu Lys His Gly Thr Leu Val Asn Ala Ala Pro Leu Lys Val 70 75 Leu Gly Ala Arg Gly Glu Pro Asn Pro Ala Ser Ser Tyr Arg Phe Glu 90 Tyr Ile Thr Gly Asp Ser Ala Gly Arg Ala Ile Thr Ala Thr Gly Ala 100 105 110 Val Leu Phe Ser Thr Arg Pro Trp Thr Thr Gly Pro Arg Pro Ala Ile 115 120 125 Ala Met Ala Pro Ser Thr Gin Gly Val Ala Gin His Cys Asp Pro Ser 130 135 140 His Thr Cys Ala Ile Gly Leu Asn Ala Phe Tyr Asp Lys Pro Phe Asp 145 150 155 160 Ala Ile Ile Ala Tyr Glu Leu Pro Val Ile Leu Trp Phe Leu Ala His 165 170 175 Gly Leu Asp Val Val Phe Ile Asp Tyr Pro Arg Asp Pro Ala Thr Gly 180 185 190 Val Gin Tyr Tyr Cys Asp Ser Ile Ala Ala Ala Lys Ser Leu Leu Asp 195 200 205 Ala Val Leu Ala Ser Arg Gln Leu Gly Leu Ser Pro Glu Ala Pro Leu 210 215 220 Gly Leu Trp Gly Phe Ser Gin Gly Gly Gly Ala Thr Gly Trp Ala Ala 225 230 235 240 Gin Leu Gin Asp Al PrAs Va Ala Pro Asp Val Arg 250 Pro Lys Ala Ala Val Val 255 Gly Gly Asn Gly 305 Leu Thr Phe Leu Giu 385 Glu Gly His Al a Leu Ser 290 Val1 Leu Pro Gly Trp 370 Leu Ser Pro Leu Pro Leu 275 Se r Ser Al a Leu Lys 355 Gi y Ar g Gln Tyr Val1 435 Pro 260 Thr Glu Asp Se r Ala 340 Gin Se r Asp Ala Phe 420 Val1 Gi y Met Val1 Gly 325 Asp Lys Lys Ser Pro 405 Arg Asp Val1 Phe Leu 310 Tyr Ile Le u Asn Trp 390 Arg As n Leu Ile Giu 295 Lys Ser Leu Gly Asp 375 Ala Val1 Leu Phe Ala 280 Glu As n Ser Asp Arg 360 Asp Asp Pro Glu Arq 265 Tyr Ile Ile Ser Asp 345 Val1 Val1 Lys Gly Lys 425 Val Leu Ala Ile Met Ser Thr Ser 315 Arg Gly 330 Leu Pro Ala Pro Ile Pro Gly. Thr 395 Arg Thr 410 Tyr Ser Asp Ala Val1 300 Cys Trp Leu Glu Ile 380 Pro Gi y G -1y Val1 270 Leu Asn Gly His Val1 350 Pro Pro Thr As n Leu 430 Asp Ala Glu Gly Gin 335 Ala Val1 Ile T rp His 415 Ile Gly Val1 Arg Ser 320 Gly Glu Leu Arg His 400 Phe Asp <210> 239 <211> 690 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (667) <223> RXA00875 <400> 239 caatttggcg gcqctgctgg gtgatcggqg gccggttgtt ccgggtgtga ttgqtgactg ggtgaggggc taacgcaaca atgtgtctaa gcttaggggc atg act act gag gtt Met Thr Thr Giu Val 1 gaa ctg gtt gtt tta gct gat tcc gag gqc aat cct att gqt act gcg Giu Leu Val Val Leu Ala Asp Ser Glu Gly Asn Pro Ile Gly Thr Ala 15 ccg Pro tcc Ser gca Ala ggg Gly ggt Gly gag Glu gtg Val1 gaa Glu gaa Glu 150 tct Ser atc Ile aaa Lys acc Thr ttg Leu cac His gt c Val1 at t Ile g ag Gi u ttt Phe 135 ccg Pro cca Pro ctg Leu gtg Val1 ttg Le u aag Lys ccg Pro ttg Leu gat Asp ttg Leu cca Pro ct t Leu gtg Val1 170 cac His aac As n aca Thr gat Asp ggg Gi y tac Tyr tgc Cys ctg Leu t tc Phe 155 ga t Asp act Thr ccg Pro tgq Trp gag Glu ctg Leu cag Gin ccg Pro gat Asp 140 gac Asp cag Gin aag Lys cgt Arg cct Pro aca Thr g ag Glu tac Tyr gtc Val1 125 ga t Asp gct Ala ctt Leu ga c Asp ggg Gi y ggt Gly aac As n gta Val1 cgt Arg 110 cac His gag Glu gt t Val1 agc a cg Thr gag Glu gtg ValI gcg Al a gat Asp 95 gct Al a ctc be u gtg ValI gat Asp gCC cat His gt g Val1 aac As n att Ile ttg be u gcg Al a tta Leu 130 ttc Phe cca Pro ctg gcg Ala cgt Arg atg Met cgc Arg att. Ile 100 ggC Gly gtg Val1 t gg T rp gtg Val caa 211 259 307 355 403 451 499 547 595 643 Ser Ala Pro Glu Leu Arg Gin Ala 175 .180 taactaacta gtctagaagc ctt ttt gac gca gag Phe Asp Ala Glu <210> 240 <211> 189 <212> PRT <213> Corynebacteriun glutamicum <400> 240 Met Thr Thr Glu Val Glu Leu Val Val 1 5 Pro Ile Gly Thr Ala Pro Lys Ala Thr 25 Leu His Phe Ala Phe Ser Thr Tyr Ile 40 Leu Val Thr Arg Arg Ala Leu Ser Lys Ala Asp Ser Glu Gly Asn His Thr Lys Asp Thr Pro Asn Pro Arg Gly Glu Leu Thr Trp Pro Gly Val Trp Thr Al a Phe Asp Ar g Gli 145 Th r Gi u Se r Arg Asp Ser 115 Ala Gli Phe Arg Met Arg Ile 100 Gly Val1 Trp Val Gin 180 Gly 70 Gi y Giu Val1 Giu Glu 150 Ser Ile Gi y Glu Pro 105 Giu Giu Lys Leu Ala 185 Pro Leu Asp Leu Pro Le u Val1 170 Phe Asp Gly T yr Cys Le u Ph e 155 Asp Asp Glu Leu Gln Pro Asp 140 Asp Gin Ala Thr Glu Tyr Val 125 Asp Ala Leu Glu As n Val1 Arg 110 His Gi u Val1 Ser Ala Asp Ala Leu Val1 Asp Ala 175 <210> 241 <211> 1308 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1285) <223> RXA01292 <400> 241 tccgcgtecc tcgaagactt aaaaaacqgg cgggattttg qcctggcaac caaageaatq tggaaagaag tgtttcaaaa, ggC Gly gga Gly gcc Ala t gg T rp acc 9gg Gly tat Tyr ggg Gly tac Tyr tcc gga Gi y gaa Gl u acc Thr etc Le u atc ct a Leu gte Val ttc Phe atg Met gac gca Ala cac His gaa Glu CCC Pro gac cta Leu gte Val1 30 gac Asp gcc Ala ct C gcc Al a 15 gaa Glu ggC Gly atg Met ga C ace Thr caa. Gin ttc Phe tee Ser ctc tgccgtettt aaaaaagcca atg aca aaa gca gtg Met Thr Lys Ala Val 1 ace gca etg ctc tta Thr Ala Leu Leu Leu aac gag cac ctc ggc Asn Glu His Leu Gly cgc tgg gac ace ggc Arg Trp Asp Thr Gly cac ttc ttt aag etc His Phe Phe Lys Leu gtq cca ctt gaa ccc Cys Gly Thr Ser Ile Asp 75 Asp His Leu Asp Val Pro Leu Giu Pro 9CC tac cgc gtc Ala Tyr Arg Val gac gac cac ggc Asp Asp His Gly gaa Glu tte atc gac gtc The Ile Asp Val acc tcc Thr Ser 100 gac atc gat Asp Ile Asp ggc 9CC aaa Gly Ala Lys 120 gcg Al a 105 atg gcc gag ctt Met Ala Glu Leu gaa tcc cgc gaa Giu Ser Arg Glu ccc ggc gcc Pro Gly Ala 115 gtc tac aac Val Tyr Asn ctq cgc acc tat Leu Arg Thr Tyr atc Ile 125 qac toe gcc aca Asp Ser Ala Thr ca g Gin 130 ctg gcc Leu Ala 135 atc gac ggc ttc Ile Asp Giy Phe tac acc aac ttc Tyr Thr Asn Phe aae ttc atc cca Asn Phe Ile Pro tta aqc ccc ggc Leu Ser Pro Gly ctq cgc ctt tta Leu Arg Leu Leu CCC Pro 160 aaa ctt eta gca Lys Leu Leu Ala ctg tcg acc tcg Leu Ser Thr Ser ct a Leu 170 aaa gtc aag gtc Lys Val Lys Val acc caa ttc ego Thr Gin Phe Arg gat aca Asp Thr 180 aaa ctg cgc Lys Leu Arg cot tog cac Pro Ser His 200 atc tta agc tac Ile Leu Ser Tyr ccc Pro 190 gca gtt tto ctc Ala Val Phe Leu tcc tca gac Ser Ser Asp 195 aco gao cto Thr Asp Leu acc cog gog ctc Thr Pro Ala Leu cac oto atg ago His Leu Met Ser 547 595 643 691 739 787 835 883 931 979 gtc caa Val Gin 215 ggc gtc tcc tat Gly Val Ser Tyr cga gge 990 tte Arg Gly Gly Phe 900 ttc ate aag Ala Phe Ile Lys gca Ala 230 cta att teg ett Leu Ile Ser Leu ate Ile 235 gac gac gec gtc Asp Asp Ala Val etc Le u 240 cac etc ggc ace His Leu Gly Thr gtc agc gca Val Ser Ala 990 tca gag Gly Ser Giu cac eac acc His His Thr 280 atc acc Ile Thr 250 acc eaa ggc cga Thr Gin Gly Arg gcc aca gge gtc Ala Thr Gly Val eaa gto Gin Vai 260 ate gaa gcc gat Ile Giu Ala Asp atc Ile 270 gtg atc age tgc Val Ile Ser Cys get gat cag Ala Asp Gin 275 geg aag ccg Ala Lys Pro gaa aoo caa etc Glu Thr Gin Leu cet get tcg ttg Pro Ala Ser Leu gag aeg Giu Thr 295 agc tgg aag eec Ser Trp Lys Asn eaa ccc ggc etc Gin Pro Gly Leu act gtg etg gtt Thr Val Leu Val 1027 ttg gce ggc gtg eag ggg gag cec ecc ctg ott ttt ect eeg act ggg Leu Ala Gly Vel Lys Gly Giu His Thr Leu Leu Phe Pro Pro Thr Gly 1075 310 315 320 acg aag att tcc gca aag ttt tcg acg gct cca ccc cag Thr Lys Ile Ser Ala Lys Phe Ser Thr Ala Pro Pro Gin 330 335 Ctt cag aat cca tct aga tct cca aga cct ccg caa cag Leu Gin Asn Pro Ser Arg Ser Pro Arg Pro Pro Gin Gin 345 350 ccg cac ccg aag 9CC acg aga acc tct tca toc tqg tcc Pro His Pro Lys Ala Thr Arg Thr Ser Ser Ser Trp Ser 360 365 370 ccg atg tct cca ttg gtc acg ggt ccq ctt acg gag aag Pro Met Ser Pro Leu Val Thr Gly Pro Leu Thr Giu Lys 375 380 385 tgg tgg gcc gga tcg caa tagcagcagt ggctcaaatt gg Trp Trp Ala Gly Ser Gin 390 395 <210> 242 <211> 395 <212> PRT <213> Corynebacterium giutamicum aat Asn att Ile 355 cag Gin aat Asn 1123 1171 1219 1267 1308 <400> 242 Met Thr Lys Aia Val Val Ile Giy Gly 1 Thr Asn Arq His Val1 Ile Arg Thr Thr 145 Ala Giu Trp Ph e Pro Asp Giu Gin 130 Asn 5 Leu Gly Gi y Le u Pro Ser Ala As n Pro Ser 165 Arg Gi y Pro Cys 70 Al a Asp Gly Le u Tyr 150 Giu Arg Ser Gly Tyr Ile Ala Ala 135 Leu Tyr Gly Tyr Ser Val1 Aila 105 Leu Asp Pro Gi y 10 Giu Thr Leu Ile Ile 90 Met Arg Gly Gly Leu 170 Leu Val1 Phe Met Asp Asp Aia Thr Phe Met 155 Lys Gly Le u Leu Asp His His Leu Ile 125 Tyr Arg Lys Ala Giu Gi y Met Asp Glu Glu Ser Asn Leu Asn 175 Lys Leu Leu Ala Leu Ser Thr Ser Gin Phe Arg Phe Ser Thr 225 His Thr Ser Leu Ser 305 Phe Pro Gin Trp Giu 385 Le u His 210 Al a Le u Gly Cys Cys 290 Thr Pro Gin Gin Ser 370 Lys Ser 195 Thr Phe Giy Val1 Al a 275 Ala Val1 Pro Asn Ile 355 Gin As n Asp 180 Ser Asp Ile Thr Gin 260 Asp Lys Le u Thr Ser 340 Pro T yr Thr Lys Leu Arg Gin Ile Leu Ser Tyr Pro Ala Vai 185 190 Asp Leu Lys Pro 245 Vali Gin Pro Vali Gly 325 Ar g Met Pro Pro Val1 Al a 230 Val1 Gly His Glu Leu 310 Thr Leu Pro Pro Ser Gin 215 Leu Ser Ser His Thr 295 Aila Lys Gin His Met 375 His 200 Gly Ile Aia Giu Thr 280 Ser Gi y Ile As n Pro 360 Ser Thr ValI Ser Ile Phe 265 Giu Trp Val Ser Pro 345 Lys Pro Pro Ser Leu Thr 250 Ile Thr Lys Lys Aila 330 Ser Al a Le u Aia Tyr Ile 235 Thr Giu Gin Asn Giy 315 Lys Arg Thr Val1 Leu Pro 220 Asp Gin Al a Le u Lys 300 Giu Phe Ser Arg Thr 380 Tyr 205 Arg Asp Gly Asp Leu 285 Gin His Ser Pro Thr 365 Giy His Gly Ala Arg Ile 270 Pro Pro Thr Th r Arg Ser Pro Leu Giy Vai Asn 255 Val1 Ala Giy Leu Ala 335 Pro Ser Leu Leu Thr Trp Trp Aia Gly Ser Gin 390 395 <210> 243 <211> 450 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(427) <223> RXA01293 <400> 243 cgatgccgca cccgaaggcc acgagaacct cttcatcctg gtcccagtac ccgccgatgt ctccattggt cacgggtccg cttacgqaga aqaatctqac atq qtg ggc cgg atc 115 Met Val Giy Arg Ile 1 gca ata gca goa qtg gct oaa att ggg cga tgg got ggc att gat ggt 163 Ala Ile Ala Ala Val Ala Gin Ile Gly Arg Trp Ala Gly Ile Asp Gly 15 ttg gaa agc ogo att gtt gtg cag cgc acc ato ggc cct gcc gac tto 211 Leu Giu Ser Arg Ile Val Val Gin Arg Thr Ile Giy Pro Ala Asp Phe 30 gca gac cga tac aac too tgg ago ggc ggg toc att ggc ccc tca cac 259 Ala Asp Arg Tyr Asn S !r Trp Ser Gly Gly Ser Ile Gly Pro Ser His 45 acc ctg goa caa tog gcg ttc ttt agg ggt tct aac aaa tcc cgc aaa 307 Thr Leu Ala Gin Ser Ala Phe Phe Arg Giy Ser Asn Lys Ser Arg Lys 60 gta gat ggc ctg tat gac gca ggt gao aco aca gtt cca ggg gtg ggc 355 Val Asp Gly Leu Tyr Asp Ala Giy Asp Thr Thr Vai Pro Gly Val Giy 75 80 gta tot atg tgt ttg atc tct gca gaa aac gtg ctc aag cgt ctc cgc 403 Val Ser Met Cys Leu Ile Ser Ala Giu Asn Val Leu Lys Arg Leu Arq 95 100 ggg gao aac agt gtg gat cgg act taacgggact tttttotttt got 450 Gly Asp Asn Ser Vai Asp Arg Thr 105 <210> 244 <211> 109 <212> PRT <213> Corynebacterium giutamioum <400> 244 Met Vai Gly Arg Ile Ala Ile Ala Ala Val Ala Gin Ile Giy Arg Trp 1 5 10 Ala Gly Ile Asp Gly Leu Giu Ser Arg Ile Val Vai Gin Arg Thr Ile 25 Gly Pro Ala Asp Phe Ala Asp Arg Tyr Asn Ser Trp Ser Gly Gly Ser 40 Ile Giy Pro Ser His Thr Leu Ala Gin Ser Ala Phe Phe Arg Gly Ser 55 Asn Lys Ser Arg Lys Val Asp Giy Leu Tyr Asp Ala Gly Asp Thr Thr 70 75 Val Pro Giy Val Gly Val Ser Met Cys Leu Ile Ser Ala Giu Asn Val 90 Leu Lys Arg Leu Arq Giy Asp Asn Ser Val Asp Arg Thr 100 105 <210> 245 <211> 1386 <212> DNA <213> Gorynebacterium giutamicum <220> <221> CDS <222> (1363) <223> RXA02310 gaaatggaca aaaagctttt tgtttaaccg tagtcgacgg ggttagtctt cttgctctcc ggactgagac aatggggttt aaggcacttg aagcaccttg gtg tct aca act Val Ser Thr Thr 1 gat gtg ttg atc Asp Val. Leu Ile ggc gcg ggc ccc Gly Ala Gly Pro ggt gcc agc gcc Gly Ala Ser Ala 9CC gtc Ala Val cat gcg gcc His Ala Ala ttc cog Cgg Phe Pro Arg act ggg ctt caa Thr Gly Leu Gin aca Thr ttg ctt atc gac Leu Leu Ile Asp gcc tcc tco Ala Ser Ser ogt gog att Arg Ala Ile 211 259 gat aaa acg tgt Asp Lys Thr Cys gat ggc ott act Asp Gly Leu Thr cac cag His Gin ota gaa ctt ota Leu Giu Leu Leu gtt got gat cag Val Ala Asp Gin aco ggg gat tat Thr Gly Asp Tyr tto Phe aao aag ggo ttg Asri Lys Giy Leu otg cat ggt ttt Leu His Gly Phe ggt Gly ggc tot gtt gag Gly Ser Val Glu 307 355 403 cog tgg cog gag Pro Trp Pro Glu tat tto aog aat Tyr Phe Thr Asn ggt too gog atg Gly Ser Ala Met tog ogg Ser Arg 100 atg gag ttc Met Giu Phe gta acc acg Val Thr Thr 120 gat ttg tta tto Asp Leu Leu Phe ogc Arg 110 ttg goa aaa tot Leu Ala Lys Ser cat gag qaa His Giu Glu 115 ttg agg 999 Leu Arg Gly tgg gag aao 909 Trp Giu Asn Ala ago Ser 125 gcc oaa gao ccc Ala Gin Asp Pro aat ttc Asn Phe 135 ttg gaa 990 gtt Leu Glu Gly Val att aat cao goa Ile Asn His Ala caa gag aaa aco Gin Giu Lys Thr gto Val1 150 aag 909 aag oat Lys Ala Lys His gt g Val 155 att att 900 gat Ile Ile Ala Asp gqt Gly 160 gto 090 too cot Val Arg Ser Pro ttc Phe 165 ggt aag aaa otg Gly Lys Lys Leu ggt Gly 170 agg cag tgg caa Arg Gin Trp Gin gat gag gtg tat Asp Giu Val Tyr ggc att Gly Ile 180 gog got cgt Ala Ala Arg tat tgt gaa act Tyr Cys Glu Thr otg tot gat gaa Leu Ser Asp Giu cog tgg att Pro Trp Ile 195 cac tcc cat His Ser His 200 gtg gaa ctq cgc Val Giu Leu Arg gat Asp 205 gaa gat ggt gtg Glu Asp Gly Val cag cca gga Gin Pro Gly 739 tat ggg Tyr Gly 215 tgg att ttc ccg Trp Ile Phe Pro ctg Leu 220 ggc aac ggc acg Gly Asn Gly Thr gtq Val1 225 aat ttg ggt tgt Asn Leu Gly Cys geg ctc tcg acg Ala Leu Ser Thr acg aga cca gcg Thr Arg Pro Ala atc aat acg aag Ile Asn Thr Lys aaa Lys 245 787 835 883 ttg ttg agc ttc Leu Leu Ser Phe tat Tyr 250 gcq ggt cag cgt Aia Gly Gin Arg cgt Arg 255 aaa qca tgq caa Lys Aia Trp Gin ctc ggg Leu Gly 260 ccc gag cac Pro Giu His tcg aat gtg Ser Asn Val 280 gac Asp 265 gtc gcc tct gcc Val Ala Ser Ala ctg cct atg ggc Leu Pro Met Gly ggc gcg gtg Gly Ala Vai 275 tcc gcc gcg Ser Ala Ala 931 979 gct ggc gcq aac Aia Gly Ala Asn t gg T rp 285 atg ctg atc ggc Met Leu Ile Gly tgt gtg Cys Val 295 aac ccg ctg *aac Asn Pro Leu Asn ggc Gly 300 gaa ggc atc gac Giu Gly Ile Asp tat Tyr 305 ggc ctg gaa acc Gly Leu Glu Thr gcg Ala 310 gcg atg gcc gtc Ala Met Ala Val acg ctt gtg gaa Thr Leu Val Giu ccc aag cqc gat Pro Lys Arg Asp ttg Le u 325 1027 1075 1123 acc ttg gta tgg Thr Leu Val Trp cca Pro 330 cat agg ttg cgc His Arg Leu Arg gac Asp 335 gcg tac ggc gag Ala Tyr Giy Glu acc ttc Thr Phe 340 atg ttg gcg Met Leu Ala ccg atg gct Pro Met Ala 360 acg gct gct cga Thr Ala Ala Arq ctg acg tac ccg Leu Thr Tyr Pro cag ttt ttq Gin Phe Leu 355 aag gcc atc: Lys Ala Ile 1171 1219 ggg ccg ctc gca Gly Pro Leu Ala ttc Phe 365 cgc ggq ccg ctg Arg Gly Pro Leu atg ccg Met Pro 375 gcg gct gjcg cgt Ala Ala Ala Arg ttg Leu 380 atg ggc aac ctg Met Gly Asn Leu aca gag gag gat Thr Giu Giu Asp aaa Lys 390 gac ctg ctc gcc Asp Leu Leu Ala ggt tgg cag gcc Gly Trp Gin Ala gc c Al a 400 gga tcc gcg att Gly Ser Ala Ile 1267 1315 1363 tgg gcg cgg aag Trp Ala Arg Lys tcc cct ctg tgg Ser Pro Leu Trp qac Asp 415 tcg act agt tct Ser Thr Ser Ser ctg gtt Leu Val 420 taatcgccga gtgcagcgcg acg <210> 246 <211> 421 1386 <212> PRT (213> Corynebacterium glutamicum <400> 246 Val Ser Thr Thr Phe Asp Val Leu Ile Ile 1 Ala Ile Thr Val1 Gly Ser Lys Pro Gly 145 ValI Giu Asp ValI Val 225 Ile Al a Met Ser Asp Pro Thr Ser Ala Ser Ile 130 Gin Arg Val Glu Val1 210 As n Asn Trp Gly Ala Al a Arg Gly Val1 Met His 115 Le u Glu Ser T yr Pro 195 Gin Le u Thr Gin Gly 275 5 ValI Se r Ile Tyr Aila Arg Glu Giy .Th r Phe 165 Ile Ile Gly Cys Lys 245 Gly Val1 His Phe His Phe 70 Pro Met Val1 As n Val1 150 ci y Ala His Tyr Giy 230 Leu Pro Ser Ala Pro Gin As n Trp Giu Thr Phe 135 Lys Lys Al a Ser Gly 215 Ala Leu Giu As n Ala Arq 40 Leu Lys Pro Phe Thr 120 Leu Ala Lys Arg His 200 Trp Leu Ser His Val 280 10 Thr Lys Leu Leu Thr 90 Asp Glu Gi y His Giy 170 Tyr Giu Phe Thr T yr 250 Val1 Gly Gly Giy Thr Leu Lys 75 Tyr Leu As n Val1 Val1 155 Arg Cys Leu Pro Asp 235 Ala Ala Ala Gi y Gin Gly Val1 His Thr Phe Se r 125 Ile Ile Trp Thr Asp 205 Gi y Arg Gin Al a Trp 285 Pro Thr Asp Ala Gly Asn Arg 110 Aia Asn Al a Gin Pro 190 Glu As n Pro Arg Leu 270 Met Ser Leu Gly Asp Phe Lys Leu Gin His Asp Arg 175 Leu Asp Gly Al a Arg 255 Leu Leu Gly Leu Le u Gin Gly Gly Al a Asp Al a Gly 160 Asp Ser Gly Thr Lys 240 Lys Pro Ile Gly Asp 290 Ser Ala Ala Cys Val Asn Pro Leu Asn Gly Glu Gly Ile Asp Tyr 305 Pro T yr Tyr Leu Ile 385 Gly Thr Gly Leu Giu Lys Gly Pro Gin 370 Thr Se r Se r Arg Giu Gin 355 Lys Giu Ala Ser Asp Thr 340 Phe Aia Glu Ile Le u 420 Thr Leu 325 Ph e Le u Ile Asp Ser 405 Val1 Aila 310 Thr Met Pro Met Lys 390 Trp Al a Le u Le u Met Pro 375 Asp Aila Val1 Pro 330 Thr Pro Ala Ala Giy 410 Asp 315 His Al a Le u Arg Arg 395 Ser Thr Arg Al a Al a Leu 380 Gly Pro Le u Le u Arg Phe 365 Met Trp Leu Val1 Arg Leu 350 Arg Gly Gin T rp Giu Asp 335 Leu Giy Asn Ala Asp 415 As n 320 Ala Thr Pro Le u Al a 400 Ser <z210> 247 <211> 1170 <212> DNA (213> Corynebacterium glutarnicum <220> <221> CDS <222> (1147) <223> RXA02718 <400> 247 tooaocaaaa ttoagcogc atccooctat togattc cgatgcccat gacottgaco togaoaaatt tooggac a cg Thr Oct Pro gga Gly caa Gln goa Ala ca g Gin gtC Val1 aag Lys ggc Gly gog Ala ctc Leu ga t Asp atc Ile aag Lys otc Leu gat Asp got Al a cg t Arg aat As n ga a Gi u got Ala gt g Val1 cot. Pro tot. Ser tto Phe 75 oaa Gin goo Ala ott Leu tot Ser 60 a to Ile aoa Thr 15 ogo Arg tgg Trp ott. Leu tgt Cys ;aag gaogtotoot tgagoagttt ~gto gtg oga gat ogt ttg Val Arg Asp Arg Leu 1 att. got gat ato ggo got Ile Ala Asp Ile Gly Ala agt tto gtg oto aat gga Ser Phe Val Leu Asn Gly got ggt tto otg gog gog Ala Gly Phe Leu Ala Ala gag too gto ott gac goo Giu Ser Val Leu Asp Ala qoo ttg att oat gao gat Ala Leu Ile His Asp Asp 80 att ate gat Ile Ile Asp gct gtg gaa Ala Val Giu cac ttt ggc His Phe Gly 120 tct tct qat acc cgg cgc gga gcc ccc aca gtt Ala Pro Thr Val Ser Ser Asp Thr Arg Arg Gly 95 cac cgg His Arg 100 403 gat cac cgc gcc Asp His Arg Ala aat ttc gaa ggc Asn Phe Giu Gly gat ccc gag Asp Pro Giu 115 qca ttg qtg Ala Leu Val 451 499 gtt tca gtc tcg Val Ser Val Ser att Ile 125 ttg gct ggc gat Leu Ala Gly Asp tgg gca Trp Ala 135 gaa gac atg ctg Glu Asp Met Leu cag Gin 140 gat tcc ggt ttg Asp Ser Gly Leu agt Ser 145 gca gag gca ttg Ala Giu Ala Leu cgc acg agg gat Arg Thr Arg Asp tgg cgt ggc atg Trp Arg Giy Met act gag gtt att Thr Glu Val Ile gg c Gi y 165 547 595 643 ggc cag atg ctt Gly Gin Leu Leu gat Asp 170 att tat cta gag Ile Tyr Leu Glu tag Ser 175 eac gcc aac gag His Ala Asn Giu tag gtg Ser Val 180 gag ctt gcg Giu Leu Ala gcg cgc eca Ala Arg Pro 200 gat Asp 185 tct gtc aac cgc Ser Val Asn Arg aaa acg gac get Lys Thr Ala Ala tac acg att Tyr Thr Ile 195 tcg cag cag Ser Pro Gin 691 739 ttg cac ctg gge Leu His Leu Gly gcc Ala 205 tcc att gct ggc Ser Ile Ala Gly ggt Gly 210 ctt atc Leu Ile 215 gac geg ate ate Asp Ala Leu Leu cac His 220 tac ggc eac gac Tyr Gly His Asp ate Ile 225 ggc att gca ttc Gly Ile Ala Phe eag Gin 230 ttg agg gat gat Leu Arg Asp Asp ctt ggt gtg ttt Leu Gly Val Phe ggg Gi y 240 gat ccc gct atc Asp Pro Ala Ile ggc aaa cca gct Gly Lys Pro Ala gga Gly 250 gac gat atc cgt Asp Asp Ile Arg gaa Glu 255 ggc aag ege act Gly Lys Arg Thr gtt ctt Val Leu 260 ett gcg cte Leu Ala Leu acg gee att Thr Ala Ile 280 cta eaa cgc get Leu Gin Arg Ala ga t Asp 270 aag caa tat act Lys Gin Ser Pro gaa get gca Giu Ala Ala 275 gaa gat att Giu Asp Ile cge gca ggt gtt Arg Ala Gly Val gga Gly 285 aag gtg act tea Lys Val Thr Ser get gte Ala Val 295 att aca gag eat Ile Thr Glu His att le 300 ega get act ggt Arg Ala Thr Gly gaa gaa gaa gtt Glu Glu Giu Val 1027 1075 gag Glu 310 eag ega att tee Gin Arg Ile Ser ctg act gaa tee Leu Thr Giu Ser ggt Gi y 320 ttg get eae etc Leu Ala His Leu ga t Asp 325 gat gta gac Asp Val Asp atc cgc tca Ile Arg Ser atc ccc gat gag gtg cgc qca cag ttg cgg gca ctg gct 1123 Ile Pro Asp Giu Val Arg Ala Gin Leu Arg Ala Leu Ala 330 335 340 acc gaa cgt cgg atg tagtagacgc gtatgacact ttt 1170 Thr Glu Arg Arg Met 345 <210> 248 <211> 349 <212> PRT <213> Corynebacterium glutamicum <400> 248 Val1 Ala Phe Gly Ser Leu Pro Glu Asp Ser 145 Thr Ala Ala Gly Ile 225 Asp Arg Asp Val1 Phe Val Ile Thr Gly Met 130 Ala Glu Asn Ala Gly 210 Gly Pro Arg Gi y Asn Al a Asp Asp His 100 Pro Le u Al a Ile Se r 180 Thr Pro Al a Ile Leu Al a Gly Al a Al a Asp Arg Glu Val1 Leu Gi y 165 Val1 Ile Gin Ph e Thr Thr Gin Phe Leu Pro Gly Gin Al a 70 Ile Ala His Trp Ala 150 Gly Glu Ala Leu Gin 230 Gly Val L ys Gly 55 Ala Ile Val1 Phe Ala 135 Arg Gin Leu Arg Ile 215 Leu Lys Thr Arg His Ser Asp Glu Gly 120 Giu Thr Leu Ala Pro 200 Asp Arg Pro Asp Ala Gin Giu Leu Thr Ile 10 Ala Val Ala His Leu Arg Ser Arg Pro Leu Tyr Ala Trp Ala Asn Ser Ser Glu Lys Leu Glu Giu Phe Ile Gin Ala Cys Ala 75 Ser Asp Thr Arg Arg Gly Ala 90 Asp His Arg Ala Asn Asn Phe 110 Ser Val Ser Ile Leu Ala Gly 125 Met Leu Gin Asp Ser Gly Leu 140 Asp Ala Trp Arg Gly Met Arg 155 160 Asp Ile Tyr Leu Glu Ser His 170 175 Ser Val Asn Arg Phe Lys Thr 190 His Leu Gly Ala Ser Ile Ala 205 Leu Leu His Tyr Gly His Asp 220 Asp Leu Leu Gly Vai Phe Gly 235 240 Gly Asp Asp Ile Arg Glu Gly Lys Ser Ser Al a 305 Le u Leu Arg Pro Pro 290 Glu Ala Arg Thr Gi u 275 Glu Glu His Al a Val1 260 Al a Asp Glu Leu Leu 340 245 Leu Al a Ile Val1 Asp 325 Al a Le u Thr Al a Glu 310 Asp Ile Leu Ile 280 I le Arg Asp Se r Ala 265 Arg Thr I le Ile Thr 345 250 Leu Ala Glu Ser Pro 330 Glu Gin Gly His Gin 315 Asp Arg Ala Gly 285 Arg Thr Val Met Asp 270 Lys Al a Glu Arg 255 Lys Val1 Thr Se r Ala 335 <210> 249 <211> 852 <212> DNA <213> Corynebacterium glutamicum <220>' <221> CDS (222> (829) (223> RXA01067 <400> 249 gctttaagg ccgaqgtgcc tggctgaact gCagcccctc aatggcaaac acaaatagtt tgcatggcag aatagcttag cagaccctga gatcaggcta agt gaa ttc caa gta Val atg Met gaa Glu t gc Cys g aa Glu aac Asn CCC Pro ga t Asp ggc Gly att Ile aac As n c qa Arg gaa Glu gga Gly cat His gaa Giu tgg Trp gat Asp atc Ile aat As n aag Lys ct t Le u ag t Ar g gt g Val1 cct Pro gga Gly cgt Arg ggt Gly cgt Ar g ctg Leu caa Gln tgg T rp gag Glu ccg Pro a CC Thr cqa Arg cta Le u acc Thr 30 gtc Val Ctt Leu gag Giu CgC Ar g aag Lys Cgt Arg Ct t Leu gC t Al a cgt Arg 80 gac Asp Ser att I le atg Met gt t Val1 g CC Al a ctc Leu cat His Glu gcg Ala aag Lys gtt Val1 ttc Phe atg Met ga a Glu Phe Ctt Leu CgC Arg gat Asp tct Ser qga Gly aag Lys 100 Gin gt C Val1 acc Th r gca Al a act Thr ttc Phe ggC Gl y 115 163 211 259 307 355 403 gtt cgt gtg ogi tgg gtt ggc cgt cgt ccc ogC ctg tgg cgt tcg gtt Val Arg Val Arg Trp Val Gly Arg Arg Pro Arg Leu Trp Arg Ser Val 105 110 115 atc cgt gag Ile Arg Giu 120 atg acc ttg Met Thr Leu 135 gac gca gcc Asp Ala Ala 150 ccg gaa caa Pro Glu Gin gac atg cca Asp Met Pro acg tca aac Thr Ser Asn 200 caa gac aag Gin Asp Lys 215 gtc ctg gaa Val Leu Glu 230 ctg Leu g cc Ala cgc Arg atc Ile gac Asp 185 ttc Phe ct Leu tac ga a Giu atg Met gao Asp act Thr 170 gi 0 Val1 cig Leu tto Phe gcc gaa Giu 125 aao As n cgc Arg aoo Thr ttc Phe ca g Gin 205 ttc Phe cta Leu ggt Gly gca Ala cog Pro 175 ogo Arg gcc Ala oag Gln aaa gao aac Lys Asp Asn 130 cgc goc gaa Arg Ala Gin 145 qaa ggo aaa Glu Gly Lys ttc oto gac Phe Len Asp too ggt gag Ser Gly Gin 195 gog gaa atg Ala Giu Met 210 gat ctg tao Asp Leu Tyr 225 gga ago gca Gly Ser Ala aco Thr ato Ile otg Len gaa Gin 180 aag Lys gtC Val gac Asp aco Thr at 0 Ile ogo Arg 165 ct Pro ogo Arg tao Tyr gog Al a 499 547 595 643 691 739 787 gat ogo aga tic 829 Tyr Ala Lys Arg Asp Arg Arg Phe taatgoooao oaacoagoog acg <210> 250 <211> 243 <212> PRT <213> Corynebacterium glutamioum <400> 250 Val Ser Glu Phe Gin Val Pro Glu Ile Pro 1 5 10 His Ile Ala Len Vai Met Asp Gly Asn Gly 25 Gly Met Lys Arg Thr Gin Gly His Lys Arg 40 Asp Val Val Asp Ala Cys Ile Gin Leu Gly 55 Tyr Ala Phe Ser Thr Gin Asn Trp Arg Arg 70 852 Ala Gin Phe Leu Pro Lys Arg Trp Ala Thr Gin Arg Gly Gin Ala Val Len Len Val Pro Tyr Len Ser Ala Ser Thr Asp Gin Val Arg 75 Phe Leu Leu His Leu Trp Lys Asp 130 Arg Ala 145 Glu Gly Phe Leu Ser Gly Ala Giu 210 Asp Leu 225. Gly Ser Gly Lys 100 Ser Thr Ile Leu Giu 180 Lys Val1 Asp Phe Gly Val1 Th r Ile Arg 165 Pro Ar g Tyr Al a As n Val1 Ile Met Asp 150 Pro Asp Thr Gin Val1 230 Asp Val1 Gi u 120 Leu Al a Gin Pro As n 200 Lys Giu Val Leu Arg Trp 105 Leu Giu Ala Met Arg Asp Ile Thr 170 Asp Val 185 Phe Leu Leu. Phe Tyr Ala Arg Val1 Thr Cys Ile 155 Giu Asp Leu Pro Lys 235 Arg Gly Ala Val1 140 Al a Lys Leu Trp Asp 220 Arg Gin Arg Giu 125 Asn Arg Thr Phe Gin 205 Phe Asp Arg Arg 110 Gi u Tyr Le u Phe Leu 190 Ser Thr Arg Asp Ar g Thr Gly Al a 160 As n Pro T yr Gin Ph e 240 <210> 251 <211> 564 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (541) <223> RXA01269 <400> 251 gattatctct gcgccgattc agctggcaat agcagcagtt tccgattcta tttcgtcaac cacgacctgg gaaagacggt att aag ttt Ile Lys Phe gaa cag cgt Giu Gin Arg gat gag tta Asp Giu Leu cga acc atg ctt gaa cca gat gaa Arg Thr Met Leu Giu Pro Asp Glu 15 cta act aaa gtt qga aag ctt ctg Leu Thr Lys Val Giy Lys Leu Leu 30 cct aca ctc tqg aat gta ttt aaa Pro Thr Leu Trp Asn Val Phe Lys gtattgagag ctcatggtcg qtg gta ttt gag atq Val Val Phe Glu Met 1 aaa cat gta act gat Lys His Vai Thr Asp cgg qaa acg aqt tta Arg Giu Thr Ser Leu ggt gat atg aqc ctt Giy Asp Met Ser Leu 11-5 163 211 259 45 qta ggg cct cga cct ttg ctt gtt agc tat ctq gaa cat tac tct tct 307 Val Gly Pro Arg Pro Leu Leu Val Ser Tyr Leu Glu His Tyr Ser Ser 60 gaa caa gct cga cgc cat gaa gtt cgt cct ggg att act ggt ttg gct 355 Glu Gin Ala Arg Arg His Giu Val Arg Pro Giy Ile Thr Giy Leu Ala 75 80 cag gtg aat ggc cgt aat caa act act tgg gat gaa cga ctt aag ttg 403 Gin Val Asn Gly Arg Asn Gin Thr Thr Trp Asp Glu Arg Leu Lys Leu 95 100 gat gtc gaa tat gtg gat cgc tgt agt ttq aaa cta gat ttc aaa ate 451 Asp Val Glu Tyr Vai Asp Arg Cys Ser Leu Lys Leu Asp Phe Lys Ile 105 110 115 tta atc gcc act gta aaa ace gtt ctt tct aaa aag ggc att agt aat 499 Leu Ile Ala Thr Val Lys Thr Val Leu Ser Lys Lys Giy Ile Ser Asn 120 125 130 gaa ggt cat gtc acq atq cca tcc ttc att gaa gaa aga aaa 541 Glu Giy His Vai Thr Met Pro Ser Phe Ile Giu Giu Arq Lys 135 140 145 tagcaqgtaa aaattttact ttc 564 <210> 252 <211> 147 <212> PRT <213> Corynebacterium giutamicum <400> 252 Val Val Phe Giu Met Ile Lys Phe Arq Thr Met Leu Giu Pro Asp Glu 1 5 10 Lys His Val Thr Asp Giu Gin Arg Leu Thr Lys Vai Giy Lys Leu Leu 25 Arg Giu Thr Ser Leu Asp Giu Leu Pro Thr Leu Trp Asn Val Phe Lys 40 Gly Asp Met Ser Leu Val Gly Pro Arg Pro Leu Leu Val Ser Tyr Leu 55 Glu His Tyr Ser Ser Glu Gin Ala Arg Arg His Giu Val Arg Pro Gly 70 75 Ile Thr Gly Leu Ala Gin Vai Asn Giy Arg Asn Gin Thr Thr Trp Asp 90 Glu Arg Leu Lys Leu Asp Val Giu Tyr Val Asp Arg Cys Ser Leu Lys 100 105 110 Leu Asp Phe Lys Ile Leu Ile Ala Thr Val Lys Thr Val Leu Ser Lys 115 120 125 Lys Giy Ile Ser Asn Giu Gly His Vai Thr Met Pro Ser Phe Ile Glu 130 135 140 Glu Arg Lys 145 <210> <211> <212> <213> <220> <221> <222> <223> 253 554 DNA Corynebacterium glutamicum CDS (531) RXA0 12 <400> 253 gta tcg gcc tat ccg Val Ser Ala Tyr Pro 1 5 ccg gcc atc atc Pro Ala Ile Ile gcg gct ctc gta Ala Ala Leu Val gga att Gly Ile tgc gcg gga Cys Ala Gly ggc gat tcc Gly Asp Ser ttg ccc cat aat Leu Pro His Asn ttt Phe gaa ccc tcg cga Glu Pro Ser Arg ata ttt atg Ile Phe Met gca gca tcg Ala Ala Ser ggc tcc atg ctc Gly Ser Met Leu ggc ctg ctg ttg Gly Leu Leu Leu acc tca Thr Ser gcg tca gga aaa Ala Ser Gly Lys atc Ile 55 aac atg agc ctg Asn Met Ser Leu tat T yr ggc qca gct gat Gly Ala Ala Asp ttt Phe atc gca ttg atc Ile Ala Leu Ile ccc atc atc gtt Pro Ile Ile Val ctc gcc gcc gtq Leu Ala Ala Val gcc Al a atc cca ctg ctc Ile Pro Leu Leu ctc gtg atg gca Leu Val Met Ala gtt agg cgc gtg Val Arg Arg Val ggc agg Gly Arg gga gca tca Gly Ala Ser ctg tcc atc Leu Ser Ile 115 ccc Pro 100 ttt tcc ccg gac Phe Ser Pro Asp aaa Lys 105 atg cat ctg cac Met His Leu His cac cga ctg His Arg Leu 110 ctc tac acc Leu Tyr Thr gga cac acc cat Gly His Thr His cgc gtg gtc cta Arg Val Val Leu tgg gcq Trp Ala 130 agc gcc gtg gca Ser Ala Val Ala ttc Phe 135 ggc gca gtg agc Gly Ala Val Ser tcc gtc gtt ccg Ser Val Val Pro ctg ttt gcc acc Leu Phe Ala Thr gga Gly 150 tcg agc atc tgt Ser Ser Ile Cys gqc Gly 155 atc ctc atc gcc Ile Leu Ile Ala gtc ValI 160 gct gtc aca gcc Ala Val Thr Ala cca gtg atg aaa Pro Val Met Lys cgg cga gcc gcc Arg Arg Ala Ala aaa ctt Lys Leu 175 gat taagtgattg tcactttgga ttg Asp <210> 254 <211> 177 <212> PRT <213> Corynebacterium glutamicum (NI <400> 254 Val Ser Ala 1 Cys Gly Thr Phe Ile Gly Leu Trp Pro 145 Ala Asp Ser Ile Pro Al a Ser Al a 130 Leu Tyr Val1 Gly Ser Leu Le u Pro 100 Gly Ala Al a Pro Pro Ala Ile Ile Ala Ala Ala Leu 5 Le u Se r Gi y Ile Asp Phe His Val1 Thr Pro Met Lys Ser 70 Leu Ser Thr Al a Gly 150 His Leu Ile 55 Pro Val1 Pro His Ph e 135 Ser Phe 25 Gi y Met Ile Al a Lys 105 Arg Ala Ile 10 Glu Leu Ser ValI Val1 90 Met Val1 Val1 Cys Pro Le u Le u Val1 Val1 His Val Se r Gly 155 Ser Leu Tyr Leu Arg be u Leu Phe 140 Ile Val1 Ile Al a Al a Al a Val1 His 110 Le u Val1 Ile Gly Phe Ala Ala Val1 Gly Arg Tyr Val1 Ala Ala Val Thr Ala Val Pro Val Met Lys Ser Arg Arg Ala Ala 165 170 Asp Lys Leu 175 <210> 255 <211> 882 <212> DNA <213> Coryriebacterium giutamicum <220> <221> CDS <222> (101)..(859) <223> RXA01576 <400> 255 atcggtgatc tttcgcqatt gatacgtgcg cgattqcgtg cccgccagct gctcaagatc aatggatttc atgacaatca agttatcatc actggggtcg gtg gca cct aac agg 115 Val Ala Pro Asn Arg 1 cct atc atg gat Pro Ile Met Asp aaa ate agc cat Lys Ilie Ser His gca cta ggc tct Ala Leu Gly Ser gca tca Ala Ser aaa aac agc Lys Asn Ser gag gca aca Glu Ala Thr qa c Asp ttt aaa gac ac Phe Lys Asp Thr tgg Trp 30 cta gtc gta oct Leu Val Val Pro tgt tat aac Cys Tyr Asn aaa aca ttc Lys Thr Phe gtt atc egg gaa Val Ile Arg Giu tta gag aac gca Leu Giu Asn Ala etc Le u cot aat Pro Asn att gtt gog gte Ile Val Ala Val aac As n gat ggc too ccg Asp Gly Ser Pro aac tcc gcg gaa Asn Ser Ala Giu gaa Giu atc cat gcg gcc Ile His Ala Ala ggc Gly 75 gca cac ctg gtc Ala His Leu Val cac ccc gtg aac His Pro Val Asn ct c Le u 307 355 403 gga caa ggt gcc Gly Gin Gly Ala ate caa acc gge Ile Gin Thr Gly ate Ile gaa tao gcc cgc Giu Tyr Ala Arg aag oaa Lys Gin 100 ccc ggt gca Pro Gly Ala gtg aaa gao Val Lys Asp 120 tao ttt gta act Tyr Phe Vai Thr gao qec gao ggc Asp Ala Asp Gly oaa eac caa Gin His Gin 115 gag gao gtg Giu Asp Val qtt ate ego atg Val Ile Arg Met gtg Val 125 gag ega etg egt Glu Arg Leu Arg gc Al a 130 gao att Asp Ile 135 ate gte ggc aeg Ile Val Gly Thr ttt gga ego eca Phe Gly Arg Pro eaa gcc gat gac Gin Ala Asp Asp 451 499 547 595 643 cag Gin 150 gtg oca eta ate Val Pro Leu Ile aag Lys 155 ogc ott gtg otg Arg Leu Val Leu ace gtg gte otg Thr Val Val Leu et g Le u 165 tea cog aaa ace Ser Pro Lys Thr oga ott ggg etc Arg Leu Gly Leu ace Thr 175 gao gee eao aac Asp Ala His Asn ggc ctg Gly Leu 180 ego gta ttc Arg Val Phe ggc atg tog Gly Met Ser 200 eaa aaa gtg geg Gin Lys Val Ala gaa atg aao ate Giu Met Asn Ile ego atg aac Arg Met Aso 195 gaa ego ggc: Giu Arg Gly cat gca too gaa His Ala Ser Glu ate Ile 205 gtc gao caa ate Val Asp Gin Ile ga t Asp 210 691 739 787 tgg ego Trp Arg 215 att tea gaa gaa Ile Ser Glu Glu gta gao ate etc Val Asp Ile Leu ace gaa tao tee Thr Giu Tyr Ser atg age aag ggg caa tee otg etc aac ggo gta aac ate otg gee gao Met Ser Lys Gly Gin Ser Leu Leu Asn Gly Val Asn Ile Leu Ala Asp 835 230 235 240 245 ggc ttc cta gcg agg aga ctc cca tgacgcagac caccacccaa atc 882 Gly Phe Leu Ala Arg Arg Leu Pro 250 <210> 256 <211> 253 <212> PRT <213> Corynebacterium glutamicum <400> 256 Val Ala Pro Asn Arg Lys Ile Ser His His Ala Leu Gly Ser Ile Pro 1 5 10 Ile Met Asp Ala Ser Lys Asn Ser Asp Phe Lys Asp Thr Trp Leu Val 25 Val Pro Cys Tyr Asn Glu Ala Thr Val Ile Arg Glu Val Leu Glu Asn 40 Ala Leu Lys Thr Phe Pro Asn Ile Val Ala Val Asn Asp Gly Ser Pro 55 Asp Asn Ser Ala Glu Glu Ile His Ala Ala Gly Ala His Leu Val Asn 70 75 His Pro Val Asn Leu Gly Gin Gly Ala Ala Ile Gin Thr Gly Ile Glu 90 Tyr Ala Arg Lys Gin Pro Gly Ala Lys Tyr Phe Val Thr Phe Asp Ala 100 105 110 Asp Gly Gin His Gin Val Lys Asp Val Ile Arg Met Val Glu Arg Leu 115 120 125 Arg Ala Glu Asp Val Asp Ile Ile Val Gly Thr Arg Phe Gly Arg Pro 130 135 140 Arg Gin Ala Asp Asp Gin Val Pro Leu Ile Lys Arg Leu Val Leu Arg 145 150 155 160 Thr Val Val Leu Leu Ser Pro Lys Thr Arg Arg Leu Gly Leu Thr Asp 165 170 175 Ala His Asn Gly Leu Arg Val Phe Asn Gin Lys Val Ala Gin Glu Met 180 185 190 Asn Ile Arg Met Asn Gly Met Ser His Ala Ser Glu Ile Val Asp Gin 195 200 205 Ile Asp Glu Arg Gly Trp Arg Ile Ser Glu Glu Pro Val Asp Ile Leu 210 215 220 Tyr Thr Glu Tyr Ser Met Ser Lys Gly Gin Ser Leu Leu Asn Gly Val 225 230 235 240 Asn Ile Leu Ala Asp Gly Phe Leu Ala Arg Arg Leu Pro 245 250 (210> (211> <212> <213> <220> <z221> <222> <223> 257 1173 DNA Corynebacterium glutamicum CDS (101) (1150) RXN 02309 (400> 257 gtgccttccg tcgactacgg ttaaacaaaa agctttttgt ccatttcact ggattcaccg aaagaatgaa tccacactcg atcaccaaag gtagcgatga atg agt agc ggc Met Ser Ser Gly 1 acc gtt cca acc Thr Val. Pro Thr cgt Ar g tcc cac ggg ctc Ser His Gly Leu gga Gly 15 aaa gaa ggt gta Lys Glu Gly Val tcc acc Ser Thr aca gga gca Thr Gly Ala atc aat gac Ile Asn Asp cag gtc gag ttt Gin Val Glu Phe gat ccc gag cta Asp Pro Glu Leu acg gcc agg Thr Ala Arg act gaa cta Thr Glu Leu gcc atg gtg cag Ala Met Val Gin gta gaa gaa ctc ctg cac Val Glu Glu Leu Leu His 45 450 tcg tcc Ser Ser ggg gaa gac ttc Gly Glu Asp Phe ct c Leu gtc gat atc gtc Val Asp Ile Val cac cta aca cga His Leu Thr Arg gcc Ala ggc ggc aaa cga Gly Gly Lys Arq cgc ccc atg ttt Arg Pro Met Phe gca Ala ctg ctg gcc tcc Leu Leu Ala Ser ttc ggt gaa aaa Phe Gly Glu Lys cca Pro ctc tcc gaa aac Leu Ser Glu Asn gtc Val1 95 atc aaa gcc gcc Ile Lys Ala Ala gtt gtc Val Val 100 gta gag atc Val Glu Ile gag gca tcc Glu Ala Ser 120 acc cac ctg gcc acc ctg tac cac gac gat Thr His Leu Ala Thr Leu Tyr His Asp Asp 105 110 atg cgc cgc ggc gtc cca agt gct aac gcg Met Arg Arg Gly Val Pro Ser Ala Asn Ala gtc atg gac Val Met Asp 115 cqa tgg gac Arg Trp Asp aac tcc Asn Ser 135 gta gcc atc ctc Val Ala Ile Leu gca Ala 140 ggc gac atc ctc Gly Asp Ile Leu gca cat gca tca Ala His Ala Ser ggt Gly 150 ctg atg agt cag Leu Met Ser Gin ggt acc gac aca Gly Thr Asp Thr gt c Val1 160 gcc cac ttt gcc Ala His Phe Ala aca ttc ggc gaa Thr Phe Gly Glu ct a Leu 170 gtc acc ggc caa Val Thr Gly Gin atg Met 175 cgc gaa aca gtc Arg Glu Thr Val ggg cca Gly Pro 180 c9c gac acc Arg Asp Thr act ggt gtc Thr Gly Val 200 ccg atc gag cac Pro Ile Glu His tac Tyr 190 acc aac gta ato Thr Asri Val Ile cgt gaa aaa Arg Glu Lys 195 atg cac gca Met His Ala 691 739 ctc ato gc tc Leu Ile Ala Ser ggo tat ttg gga Gly Tyr Leu Gly ggo cC Gly Ala 215 gca cot gaa cac Ala Pro Glu His atc Ile 220 gac gcc ctg aag Asp Ala Leu Lys aac As n 225 ttc gqo goa qcc Phe Gly Ala Ala gtc Val1 230 ggc atg ato ttc Gly Met Ile Phe atc gtc gac gac Ile Val Asp Asp atc gac atc ttc Ile Asp Ile Phe gaa aco cac gaa Giu Thr His Giu tCC Se r 250 gga aaa acg coo Gly Lys Thr Pro ggc Gly 255 acc gac ctc cgc Thr Asp Leu Arg gaa qgt Giu Gly 260 gta ttc acc Val Phe Thr ggc gca gaa Gly Ala Giu 280 cca gtg ctc tac Pro Val Leu Tyr ctc Cgt gaa gao Leu Arg Glu Asp acc ccc gto Thr Pro Val 275 gac gac gag Asp Asp Giu ctc cgc gac atc Leu Arg Asp Ile acc ggc oct cta Thr Gly Pro Leu gaa Giu 290 acc gtc Thr Val 295 aac cac gtc Ctc Asn His Val Leu gag Giu 300 ctc ctc tcc caa Leu Leu Ser Gin ggc gga cgc caa Gly Gly Arg Gin gcc ctc gao gaq Ala Leu Asp Giu tac cgc tao atg Tyr Arg Tyr Met ato goc aao gca Ile Ala Asn Ala ga a Gi u 325 1027 1075 1123 oto gac ogc oto Leu Asp Arg Leu oca Pro 330 gac agc acc gto Asp Ser Thr Val aag Lys 335 gaa goc oto 090 Giu Ala Leu Arg aac ctt Asn Leu 340 gca acc ttc Ala Thr Phe gtc aag cgc gtc Val Lys Arg Val taacccoqta atccaccact 1170 1173 <210> 258 <211> 350 <212> PRT <213> Corynebacterium giutamicum <400> 258 Met Ser Ser Gly Arg Thr Val Pro Thr Arg 1 5 10 Ser His Gly Leu Gly Lys Giu Gly Val Ser Thr Thr Gly Ala Ser 25 Gin Val Giu Phe Gly Asp Pro Giu Leu Thr Ala Arg Ile Asn Asp Ala Met Val Gin Val Giu Giu Leu 40 Leu His Thr Glu Leu Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val 55 Met His Leu Thr Arg Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala 70 75 Leu Leu Ala Ser Glu Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile 90 Lys Ala Ala Val Val Val Glu Ile Thr His Leu Ala Thr Leu Tyr His 100 105 110 Asp Asp Val Met Asp Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala 115 120 125 Asn Ala Arg Trp Asp Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu 130 135 140 Leu Ala His Ala Ser Gly Leu Met Ser Gin Leu Gly Thr Asp Thr Val 145 150 155 160 Ala His Phe Ala Glu Thr Phe Gly Glu Leu Val Thr Gly Gin Met Arg 165 170 175 Glu Thr Val Gly Pro Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn 180 185 190 Val Ile Arg Glu Lys Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu 195 200 '205 Gly Ala Met His Ala Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys 210 215 220 Asn Phe Gly Ala Ala Val Gly Met Ile Phe Gin Ile Val Asp Asp Ile 225 230 235 240 Ile Asp Ile Phe Ser Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr 245 250 255 Asp Leu Arg Glu Gly Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg 260 265 270 Glu Asp Thr Pro Val Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro 275 280 285 Leu Glu Asp Asp Glu Thr Val Asn His Val Leu Glu Leu Leu Ser Gin 290 295 300 Ser Gly Gly Arg Gin Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp 305 310 315 320 Ile Ala Asn Ala Glu Leu Asp Arg Leu Pro Asp Ser Thr Val Lys Glu 325 330 335 Ala Leu Arg Asn Leu Ala Thr Phe Thr Val Lys Arg Val Gly 340 345 350 <210> 259 <211> <212> <213> <220> <221> <222> <223> 1075 DNA Corynebacteriun glutamicum CDS (101)..(1075) FRXA02309 <400> 259 gtgecttccg tcgactacgg ttaaacaaaa agetttttgt aaagaatgaa tccacactcg atcaccaaag gtagcgatga ccatttcact ggattcaccg atg agt age ggc cga 11 Met Ser Ser Gly Arg 1 ace gtt cca ace Thr Val Pro Thr tcc cac ggg ctc Ser His Gly Leu aaa gaa ggt gta Lys Glu Gly Val tce acc Ser Thr aca gga gca Thr Gly Ala atc aat gac Ile Asn Asp cag gte gag ttt Gin Val Giu Phe ggt Gly gat ccc gag cta Asp Pro Giu Leu acg gcc agg Thr Ala Arg act gaa cta Thr Glu Leu gcc atg gtg cag Ala Met Val Gin gaa gaa etc ctg Giu Glu Leu Leu teg tcc Ser Ser ggg gaa gac tte Gly Glu Asp Phe etc Leu gte gat atc gte Val Asp Ile Val cac cta aca cga His Leu Thr Arg ggc ggc aaa ega Gly Gly Lys Arg ege ccc atg ttt Arg Pro Met Phe gea Al a ctg etg gee tcc Leu Leu Ala Ser gag Gl u ttc ggt gaa aaa Phe Gly Glu Lys etc tee gaa sac Leu Ser Glu Asn ate ass gee gee Ile Lys Ala Ala gtt gte Val Val 100 gta gag ate Val Glu Ile gag gea tee Glu Ala Ser 120 ace Th r 105 cac ctg gee ace His Leu Ala Thr ctg Leu 110 tac cac gac gat Tyr His Asp Asp gte atg gac Val Met Asp 115 ega tgg gac Arq Trp Asp atg cgc cge ggc Met Arg Arg Gly eca agt get aac Pro Ser Ala Asn geg Ala 130 sac tee Asn Ser 135 gta gee ate etc Val Ala Ile Leu gca Ala 140 ggc gae ate etc Gly Asp Ile Leu gca eat gca tea Ala His Ala Ser ggt Gly 150 etg atg agt eag Leu Met Ser Gin et g Le u 155 ggt ace gac aca Gly Thr Asp Thr gte Val1 160 gee eac ttt gee Ala His Phe Ala ga a Giu 165 aca ttc gge gaa Thr Phe Gly Glu gte ace gge eaa Val Thr Gly Gin ege gaa aca gte Arg Glu Thr Val ggg eca Gly Pro 180 ege gac ace gac ceg ate gag ese tac ace aac gta ate cgt gsa aaa Arg Asp Thr Asp Pro Ile Giu His Tyr Thr Asn 185 190 act ggt gte ctc atc gee tee gea ggc tat ttg Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu 200 205 ggc gcc gca cet gaa cac atc gac gee ctg aag Gly Ala Ala Pro Giu His Ile Asp Ala Leu Lys 215 220 gtc ggc atg atc ttc caa atc gtc gae gac ate Val Gly Met Ile Phe Gin Ile Val Asp Asp Ile 230 235 240 gaa acc cac gaa tec gga aaa acg ccc ggc ace Giu Thr His Giu Ser Gly Lys Thr Pro Gly Thr 250 255 gta tte acc ctc cca gtg ctc tac gca ctc cgt Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg 265 270 ggc gea gaa ctc cgc gee etc cte aec ggc cct Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro 280 285 ace gte eec cac gte etc gag etc etc tee caa Thr Val Asn His Vai Leu Giu Leu Leu Ser Gin 295 300 gca gee etc gac gag gte tee cge tee atg gae Ala Ala Leu Asp Giu Val Tyr Arg Tyr Met Asp 310 315 320 260 (211> 325 <2i2> PRT <213> Corynebacteriur glutamicum <400> 260 Met Ser Ser Gly Arg Thr Val Pro Thr Arg Ser 1 5 Giu Gly Val Ser Thr Thr Gly Ala Ser Gin Val 25 Giu Leu Thr Ala Arg Ile Asn Asp Ala Met Val 40 Leu His Thr Giu Leu Ser Ser Gly Giu Asp Phe Met His Leu Thr Arq Ala Gly Gly Lys Arg Phe 70 75 Leu Leu Ala Ser Giu Phe Gly Giu Lys Pro Leu Lys Ala Ala Val Val Val Glu Ile Thr His Leu Val Ile Arg 195 gga gee atg Giy Ala Met 210 eec tte ggc Asn Phe Gly 225 ate gac ate Ile Asp Ile gae etc ege Asp Leu Arg gee gae ace Giu Asp Thr 275 eta gee gee Leu Glu Asp 290 tee gge gga Ser Gly Gly 305 ate gee aec Ile Ala Asn Glu Lys cac gee His Ala gea gee Ala Ala tte teg Phe Ser 245 gae ggt Glu Gly 260 eec gte Pro Val gee gag Asp Giu ege cee Arg Gin gee gaa Ala Glu 739 787 835 883 931 979 1027 1075 Gly Phe Val1 Vali Pro Gi u Tb r Le u Gly Giu Asp Met As n Le u Lys Pro Leu Val1 Ala Ile His 100 105 110 Asp Asp Val Met Asp Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala 115 120 125 Asn Ala Arg Trp Asp Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu 130 135 140 Leu Ala His Ala Ser Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val 145 150 155 160 Ala His Phe Ala Glu Thr Phe Gly Giu Leu Val Thr Gly Gin Met Arg 165 170 175 Giu Thr Val Gly Pro Arg Asp Thr Asp Pro Ile Giu His Tyr Thr Asn 180 185 190 Val Ile Arg Glu Lys Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu 195 200 205 Gly Ala Met His Ala Gly Ala Ala Pro Giu His Ile Asp Ala Leu Lys 210 215 220 Asn Phe Gly Ala Ala Val Gly Met Ile Phe Gin Ile Val Asp Asp Ile 225 230 235 240 Ile Asp Ile Phe Ser Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr 245 250 255 Asp Leu Arg Glu Gly Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg 260 265 270 Giu Asp Thr Pro Val Gly Ala Giu Leu Arq Asp Ile Leu Thr Gly Pro 275 280 285 Leu Giu Asp Asp Glu Thr Val Asn His Val Leu Giu Leu Leu Ser Gin 290 295 300 Ser Gly Gly Arq Gin Ala Ala Leu Asp Gin Val Tyr Arq Tyr Met Asp 305 310 315 320 Ile Ala Asn Ala Glu 325 <210> 261 <211> 1767 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1744) <223> RXN00477 <400> 261 tgcgggagcq aatcagagtt ccacttcata tcaaactctc tacactcgct agagccacga tgaaaggtct atctatgagc atctacagaa agaattcgtg atg aaq qtc tcg act 115 Met Lys Val Ser Thr 1 aaa act cca cgc Lys Thr Pro Arg tcc Ser tca ggt acc gcc Ser Gly Thr Ala gtc ata ggc gca Val Ile Gly Ala ggt gtt Gly Val gct ggt tta Ala Gly Leu act gtt ttg Thr Val Leu act tct gca, ctt Thr Ser Ala Leu gca cgt gat ggc Ala Arg Asp Gly tgg caa gta Trp Gin Val gga tcg ctt Giy Ser Leu gaa aaa aat act Glu Lys Asn Thr gat Asp 45 qtc ggt ggc cga Val Gly Giy Arg gct Al a gaa ata Glu Ile tca ggc ttt cct Ser Gly Phe Pro ttt cga tgg gat Phe Arg Trp Asp gga cct tct tgg Gly Pro Ser Trp tac T yr ctc atg ccc gag Leu Met Pro Glu gcc Ala 75 ttt gac cat ttc Phe Asp His Phe ttc Phe gca ctt ttt gqt Ala Leu Phe Gly tgt act tct gat Cys Thr Ser Asp ctc gat ttg gta Leu Asp Leu Val tta acg cct ggt Leu Thr Pro Gly tat cga Tyr Arq 100 gtt ttt tct Val Phe Ser gaa gca att Giu Ala Ile 120 ggc Gly 105 aca cat gac gct Thr His Asp Ala gat gtc ccc act Asp Val Pro Thr ggg cgt gaa Gly Arg Glu 115 ggt gca aaa Gly Ala Lys gcg cta ttc gaa Ala Leu Phe Glu tcc Se r 125 atc gaa ccc ggc Ile Glu Pro Gly gcg Al a 130 cta gga Leu Gly 135 aat tat ctt gat Asn Tyr Leu Asp gcg gca gac gcc Ala Ala Asp Ala gac att gcc att Asp Ile Ala Ile ga t Asp 150 aga ttc ctt tat Arg Phe Leu Tyr aat As n 155 aat ttc tcc acg Asn Phe Ser Thr tta Le u 160 ggc ccg ctg ctt Gly Pro Leu Leu cac His 165 cgq gat qta ctg Arg Asp Val Leu cga gct ggc cga Arg Ala Giy Arg ttt tct cta ctg Phe Ser Leu Leu acc cgt Thr Arg 180 tct tta caa Ser Leu Gin cag atc cta. Gin Ile Leu 200 aag Lys 185 tac gta aat agt Tyr Val Asn Ser ttc agt agc ccg Phe Ser Ser Pro gtg ttg cgc Val Leu Arg 195 ccc act act Pro Thr Thr acc tat cca gca Thr Tyr Pro Ala gtc Val1 205 ttc ctq tct tcc Phe Leu Ser Ser cga Arg 210 acc cca Thr Pro 215 tcg atg tac cac Ser Met Tyr His atq agt cat acc Met Ser His Thr ttg gtg cag gga Leu Val Gin Gly gtg ValI 230 aaa tac cct ata Lys Tyr Pro Ile gg t Gly 235 ggt ttt act gca Gly Phe Thr Ala gtg Val1 240 gtt aac gct ctg Val Asn Ala Leu cag tta gcg ctg Gin Leu Ala Leu aac ggg gtt gag Asn Gly Val Giu ttt Phe 255 caa ctc qat tct Gin Leu Asp Ser gag gtc Giu Val 260 883 ati tcc atc Ile Ser Ile gtg agc ttg Val Ser Leu 280 aac Asn 265 act gct tca tcg Thr Ala Ser Ser a gg Arg 270 ggc aac aca agc Gly Asn Thr Ser gcc aca ggt Ala Thr Gly 275 gcg gat ctt Ala Asp Leu ctt cac aac aga Leu His Asn Arg gtg' caa aat cta Val Gin Asn Leu gtg gtt Val Val 295 tca gca ggc gac Ser Ala Gly Asp cta Le u 300 cac cat aca gaa His His Thr Glu aat Asn 305 aat ctg ctt ccc Asn Leu Leu Pro gaa ctt cga acc Glu Leu Arg Thr ccc gaa cga tat Pro Giu Arg Tyr tcc aat cgc aat Ser Asn Arg Asn 1027 1075 1123 gga att gga gcg Gly Ile Gly Ala gta Val£ 330 ita atc ctc ctg Leu Ile Leu Leu ggc Giy 335 gta aaa gga gag Vai Lys Gly Glu ita ccc Leu Pro 340 cag ctc gac Gin Leu Asp cac aac ctt ttc His Asn Leu Phe aqt gaa gat tgg Ser Glu Asp Trp aca gat gat Thr Asp Asp 355 cac aai gca His Asn Ala 1171 tti gci Phe Ala tca aat Ser Asn 375 gta gtt Val Val 360 ttc gac ggg Phe Asp Giy caa ctt acc cgc Gin Leu Thr Arg tcc ait tat gtc Ser Ile Tyr Val tcc Ser 380 aag cct tca acg Lys Pro Ser Thr icc Ser 385 gaa gac ggc gtt Gin Asp Gly Val 1219 126-7 1315 1363 cct gct gga tac Pro Ala Gly Tyr aac ctt ttt gtt Asn Leu Phe Val att ccg acc aag Ile Pro Thr Lys gcc Al a 405 ici agc agc aic Ser Ser Ser Ile ggc Gly 410 cac ggt gat gcg His Giy Asp Ala tat Tyr 415 atg cag tcg gct Met Gin Ser Ala tca gca Ser Ala 420 tcc gtg gaa Ser Val Giu gcc ggc atc Ala Gly Ile 440 atc gcg tca cat Ile Ala Ser His aic aat caa att Ile Asn Gin Ile gct acg caa Ala Thr Gin 435 cgc acc at Arg Thr Ile 1411 1459 cct gac cic act Pro Asp Leu Thr cga ati gtg gtc Arg Ile Val Vai ggc cct Gly Pro 455 gcg gat itt gag Ala Asp Phe Gin cac His 460 cgc tac cat tca Arg Tyr His Ser ig T rp 465 gta ggc agt gcg Val Gly Ser Ala 1507 1555 ctg Leu 470 ggt cca gca cat Gly Pro Ala His acc Thr 475 ctc aga cag tcc Len Arg Gin Ser ttc tta aga ggg Phe Leu Arg Gly cgc Arg 485 aat agc tcc cgc aag gtc aat aac cic tic tat tcc ggt gcc acc acc 10 1603 ASn Ser Ser Arg Lys Val Asn 490 gtc ccg gqt gta gga ata ccc Val Pro Gly Val Gly Ile Pro 505 att aag cgt tta cat gcc gat Ile Lys Arg Leu His Ala Asp 520 ttg ccg cct aaa acg aca cca Leu Pro Pro Lys Thr Thr Pro 535 540 taaattttga tccctatcat cga As n atg Met acc Thr 525 t ct Ser Phe 495 tta Leu g ca Ala aag Lys T yr att Ile gga Gi y acc Thr Ser tct Ser cca Pro tca Ser 545 Ala Thr 500 gag aat Glu Asn Thr att, Ile gaa cca Glu Pro cat His 1651 1699 1744 1767 <210> 262 <211> 548 <212> PRT <213> Corynebacterium glutamicum <400> 262 Met Lys Val Ser Thr Lys Thr 1 Ile Asp Arg Thr Al a Thr Pro Gi y Tyr 145 Gly Ser Ser Al a Trp Gly Pro Phe Gly Gly 115 Gly Ile Leu Le u Val1 5 Val1 Val1 Leu Trp Al a Arg Glu Lys Ile His 165 Arg Arg Ala Thr Glu Tyr 70 Gys Val1 Giu Le u Asp 150 Arg Ser Gin Pro Arg Ser 10 Leu Ala Thr Leu Giu Lys Ser Gly Phe Met Pro Glu Ser Asp Tyr 90 Ser Gly Thr 105 Ile Ala Leu 120 Asn Tyr Leu Phe Leu Tyr Val Leu Thr 170 Gin Lys Tyr 185 Leu Thr Tyr Ser Ser Asn Pro Al a 75 Leu His Phe Asp As n 155 Arg Val Pro Gly Ala Thr Gly Phe Asp Asp Glu Ser 140 Asn Ala Asn Ala Val Ala Gly Trp Phe Glu Asp Giu Asp Thr Leu 175 Phe Leu Val1 Arg Gi y Asp Ph e Leu Vali Pro Al a Le u 160 Phe Se r Se r 195 200 205 Ser Arg Pro Thr Thr Thr Pro Ser Met Tyr His Leu Met Ser His Thr 210 215 220 Asp Leu Val Gin Gly Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val 225 230 235 240 Val Asn Ala Leu His Gin Leu Ala Leu Glu Asn Gly Val Glu Phe Gin 245 250 255 Leu Asp Ser Glu Val Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn 260 265 270 Thr Ser Ala Thr Gly Val Ser Leu Leu His Asn Arg Lys Val Gin Asn 275 280 285 Leu Asp Ala Asp Leu Val Val Ser Ala Gly Asp Leu His His Thr Glu 290 295 300 Asn Asn Leu Leu Pro Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp 305 310 315 320 Ser Asn Arg Asn Pro Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val 325 330 335 Lys Gly Glu Leu Pro Gin Leu Asp His His Asn Leu Phe Phe Ser Glu 340 345 350 Asp Trp Thr Asp Asp Phe Ala Val Val Phe Asp Gly Pro Gin Leu Thr 355 360 365 Arg Pro His Asn Ala Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr 370 375 380 Ser Glu Asp Gly Val Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu 385 390 395 400 Ile Pro Thr Lys Ala Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met 405 410 415 Gin Ser Ala Ser Ala Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn 420 425 430 Gin Ile Ala Thr Gin Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val 435 440 445 Val Lys Arg Thr Ile Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser 450 455 460 Trp Val Gly Ser Ala Leu Gly Pro Ala His Thr Leu Arg Gin Ser Ala 465 470 475 480 Phe Leu Arg Gly Arg Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr 485 490 495 Ser Gly Ala Thr Thr Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile 500 505 510 Ser Ala Glu Asn Ile Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly 515 520 525 Pro Leu Pro Glu Pro Leu Pro Pro Lys Thr Thr Pro Ser Gin Lys Thr 530 535 540 Ser Tyr Asp His 545 <210> 263 <211> 1767 <212> DNA <213> Corynebacterium <220> <221> CDS <222> (101)..(1744) <223> FRXA00477 <400> 263 tgcgggagcg aatcagagtt glut amicum ccacttcata tcaaactctc tacactcgct agagccacqa tgaaaggtct atctatgagc atctacaqaa agaattcgtg atg aag qtc tcg Met Lys Val Ser 115 163 aaa act cca cgc Lys Thr Pro Arq tca ggt acc gcc gta gtc ata ggc gca Ser Gly Thr Ala Val Val Ile Gly Ala ggt gtt Gly Val gct ggt tta Ala Gly Leu act gtt ttg Thr Val Leu act tct gca ctt Thr Ser Ala Leu gca cgt gat ggc Ala Arg Asp Gly tgg caa gta Trp Gln Val gga tcg ctt Gly Ser Leu 211 259 gaa aaa aat act Glu Lys Asn Thr gtc ggt ggc cga Val Gly Gly Arg gjc t Ala gaa ata Glu Ile tca ggc ttt cct Ser Gly Phe Pro ggc Gly ttt cga tgg gat Phe Arg Trp Asp gga cct tct tgg Gly Pro Ser Trp tac Tyr ctc atg ccc gag Leu Met Pro Glu gcc Al a ttt qac cat ttc Phe Asp His Phe gca ctt ttt ggt Ala Leu Phe Gly tgt act tct gat Cys Thr Ser Asp ctc gat ttg gta Leu Asp Leu Val ga a Glu tta acg cct ggt Leu Thr Pro Gly tat cga Tyr Arg 100 gtt ttt tct Val Phe Ser gaa gca att Glu Ala Ile 120 aca cat gac gct Thr His Asp Ala gat gtc ccc act Asp Val Pro Thr ggg cgt gaa Gly Arg Glu 115 ggt qca aaa Gly Ala Lys gcg cta ttc qaa Ala Leu Phe Glu atc gaa ccc ggc Il~e Glu Pro Gly g cq Ala 130 cta gga Leu Gly 135 aat tat ctt gat Asn Tyr Leu Asp agc Ser 140 gcg gca gac gcc Ala Ala Asp Ala tat Tyr 145 gac att gcc att Asp Ile Ala Ile ga t Asp 150 aga ttc ctt tat Arg Phe Leu Tyr aat ttc tcc acg Asn Phe Ser Thr tta ggc ccg ctg Leu Gly Pro Leu 160 ttt. tct cta ctg Phe Ser Leu Leu ct t Leu 595 643 cgg gat gta ctg Arg Asp Val Leu acc Thr 170 cga gct ggc cga Arg Ala Gly Arg acc cgt Thr Arg 180 tct tta caa. Ser Leu Gin cag atc cta Gin Ile Leu 200 tac gta aat agt Tyr Val Asn Ser ttc agt agc ccg Phe Ser Ser Pro qtg ttq cgc Val Leu Arg 195 ccc act act Pro Thr Thr acc tat cca gca Thr Tyr Pro Ala gtc Val1 205 ttc ctg tct tc Phe Leu Ser Ser acc cca Thr Pro 215 tcg atg tac cac Ser Met Tyr His atg agt cat acc Met Ser His Thr ga t Asp 225 ttg gtg cag gga, Leu Val Gin Gly aaa tac cct ata Lys Tyr Pro Ile ggt Gly 235 ggt ttt act gca Gly Phe Thr Ala gtt aac get ctg Val Asn Ala Leu cag tta gcg ctg Gin Leu Ala Leu aac ggg gtt gag Asn Gly Val Giu caa etc gat tct Gin Leu Asp Ser gag gtc Glu Val 260 att tcc atc Ile Ser Ile gtg age ttg Val Ser Leu 280 act gct tea tcg Thr Ala Ser Ser agg Ar q 270 ggc aac aca agc Gly Asn Thr Ser gcc aca ggt Ala Thr Giy 275 geg gat ctt Ala Asp Leu 931 979 ctt cac aac aga Leu His Asn Arg aaa Lys 285 gtg caa aat eta Val Gin Asn Leu ga t Asp 290 gtg gtt Val Val 295 tca. gca ggc gao Ser Ala Giy Asp cac cat aca qaa His His Thr Giu aat As n 305 aat ctg ctt ccc Asn Leu Leu Pro egg Arg 310 gaa ctt cga acc Giu Leu Arg Thr tat T yr 315 ccc gaa ega tat Pro Glu Arg Tyr tcc aat egc aat Ser Asn Arg Asn gga att gga gcg Gly Ile Gly Ala tta ate etc ctq Leu Ile Leu Leu gta aaa gga gag Val Lys Gly Giu tta ccc Leu Pro 340 1027 1075 1123 1171 1219 cag etc gac Gin Leu Asp ttt get gta Phe Ala Val 360 cac aac ctt ttc His Asn Leu Phe agt gaa gat tgg Ser Glu Asp Trp aca gat gat Thr Asp Asp 355 cac aat qca His Asn Ala gtt tte gac ggg Val Phe Asp Giy ct Pro 365 caa ctt acc cqc Gin Leu Thr Arg tca aat Ser Asn 375 tee att tat gtc Ser Ile Tyr Val aag cet tea aeg Lys Pro Ser Thr tcc Ser 385 gaa gac ggc gtt Giu Asp Giy Val 1267 gca oct get gga tao gaa aac ott ttt gtt tta att cog ace aag gee 31 1315 Ala Pro 390 tct agc Ser Ser tcc gtg Ser Val gc ggc Ala Gly ggC cct Gly Pro 455 ctg ggt Leu Gly 470 aat agc Asn Ser gtc ccg Val Pro att aag Ile Lys ttg ccg Leu Pro 535 Al a agc Ser gaa Glu atc Ile 440 gcg Ala cca Pro tcc Ser gg t Gly cgt Arg 520 cct Pro Gly atc Ile aca Thr 425 cct Pro gat Asp gca Ala cgc Arg gta Val1 505 tta Leu aaa Lys T yr gg C Gly 410 atc Ile gac Asp ttt Phe cat His aag Lys 490 qga Gly cat His acg Thr Glu 395 cac His gcg Ala ctc Le u gag Glu acc Thr 475 qtC Val1 ata Ile gcc Al a aca As n qq t Gi y t ca Ser act Thr cac His 460 ctc Le u aat Asn ccc Pro gat Asp c ca Leu gat Asp cat His gac Asp 445 cgc Arg aga Arg aac As n at g Met acc Thr 525 P he gcg Ala gca Ala 430 cga Arg tac Tyr cag Gin ct C Leu tgt Cys 510 agt Ser ValI tat Tyr 415 atc Ile at t Ile cat His tcc Ser ttc Phe 495 tta Le u gca Al a Leu 400 atg Met aat As n gtg Val1 tca Se r gc t Al a 480 tat Tyr att Ile giga Gi y Ile cag Gin caa Gin gtC Val1 tqg Trp 465 ttc Phe t cc Se r tct Ser cca Pro Pro t cg Ser att Ile aaa Lys 450 gt a Val1 tta Leu ggt Gi y gcc Ala ctg Leu 530 Thr gct Ala gct Ala 435 cgc Arg ggc Gly a ga Arg gcc Ala gag Giu 515 ccc Pro Lys tca Ser 420 a cg Thr acc Thr agt Se r ggg Gly acc Thr 500 aat Asn gaa Glu Al a 405 gca Al a caa Gin att Ile gcg Al a cgC Arg 485 acc Thr att Ile cca Pro 1363 1411 1459 1507 1555 1603 1651 1699 tct caa aag acc tca tac Thr Pro Ser Gin Lys Thr Ser Tyr gat cat Asp His 1744 taaattttga tccctatcat cga <210> 264 <211> 548 <212> PRT <213> Corynebacterium glutarnicum <400> 264 Met Lys Val Ser Thr Lys Thr Pro Arg Ser 1 5 10 Ile Gly Ala Gly Val Ala Gly Leu Ala Thr 25 Asp Gly Trp Gin Val Thr Val Leu Glu Lys 40 Arg Ala Gly Ser Leu Giu Ile Ser Gly Phe 55 Thr Gly Pro Ser Trp Tyr Leu Met Pro Glu 1767 Ser Gly Thr Ala Val Val Ser Ala Leu Leu Ala Arg Asn Thr Asp Val Gly Gly Pro Gly Phe Arg Trp Asp Ala Phe Asp His Phe Phe Ala Thr Pro Gly Tyr 145 Gly Ser Ser Ser Asp 225 Val Leu Thr Leu Asn 305 Ser Lys Asp Arg Leu Phe Gly Ala Pro Thr Ala 130 Asp Pro Leu Pro Arg 210 Leu Asn Asp Ser Asp 290 Asn Asn Gly Trp Pro 370 Gly Gly 115 Gly lie Leu Leu Val 195 Pro Val Ala Ser Ala 275 Ala Leu Arg Glu Thr 355 His Tyr 100 Arg Ala Ala Leu Thr 180 Leu Thr Gin Leu Glu 260 Thr Asp Leu Asn Leu 340 Asp Asn Arg Glu Lys Ile His 165 Arg Arg Thr Gly His 245 Val Gly Leu Pro Pro 325 Pro Asp Ala 70 Cys Val Glu Leu Asp 150 Arg Ser Gin Thr Val 230 Gin Ile Val Val Arg 310 Gly Gin Phe Ser Phe Ala Gly 135 Arg Asp Leu Ile Pro 215 Lys Leu Ser Ser Val 295 Glu Ile Leu Ala Asn 375 75 Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu Ser Ile 120 Asn Phe Val Gin Leu 200 Ser Tyr Ala Ile Leu 280 Ser Leu Gly Asp Val 360 Ser Gly 105 Ala Tyr Leu Leu Lys 185 Thr Met Pro Leu Asn 265 Leu Ala Arg Ala His 345 Val Ile 90 Thr Leu Leu Tyr Thr 170 Tyr Tyr Tyr Ile Glu 250 Thr His Gly Thr Val 330 His Phe Tyr His Phe Asp Asn 155 Arg Val Pro His Gly 235 Asn Ala Asn Asp Tyr 315 Leu Asn Asp Val Glu 395 Asp Glu Ser 140 Asn Ala Asn Ala Leu 220 Gly Gly Ser Arg Leu 300 Pro Ile Leu Gly Ser 380 Asn Ala Ser 125 Ala Phe Gly Ser Val 205 Met Phe Val Ser Lys 285 His Glu Leu Phe Pro 365 Lys Leu Val 110 Ile Ala Ser Arg Gin 190 Phe Ser Thr Glu Arg 270 Val His Arg Leu Phe 350 Gin Pro Phe Asp Glu Asp Thr Leu 175 Phe Leu His Ala Phe 255 Gly Gin Thr Tyr Gly 335 Ser Leu Ser Val Val Pro Ala Leu 160 Phe Ser Ser Thr Val 240 Gin Asn Asn Glu Trp 320 Val Glu Thr Thr Leu 400 Ser Glu Asp Gly Val Ala Pro Ala Gly Tyr 385 390 Ile Pro Thr Lys Ala Ser Ser Ser Ile Gly His 405 410 Gin Ser Ala Ser Ala Ser Val Glu Thr Ile Ala 420 425 Gln Ile Ala Thr Gin Ala Gly Ile Pro Asp Leu 435 '440 Val Lys Arg Thr Ile Gly Pro Ala Asp Phe Glu 450 455 Trp Val Gly Ser Ala Leu Gly Pro Ala His Thr 465 470 475 Phe Leu Arg Gly Arg Asn Ser Ser Arg Lys Val. 485 490 Ser Gly Ala Thr Thr Val Pro Gly Val Gly Ile 500 505 Ser Ala Glu Asn Ile Ile Lys Arg Leu His Ala 515 520 Pro Leu Pro Glu Pro Leu Pro Pro Lys Thr Thr 530 535 Ser Tyr Asp His 545 <210> 265 <211> 954 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (931) <223> RXA00478 <400> 265 accagaagca gcctcagcta tgacacacca aaattcgcct gagactttac aatcggqcct cattcaaggc ttcacataaa Gly Ser Thr His 460 Leu As n Pro Asp Pro 540 Asp His Asp 445 Arg Arg As n Met Thr 525 Ser Ala Ala 430 Arg Tyr Gin Le u Cys 510 Se r Gin Met As n Val1 Ser Ala 480 T yr Ile Gly Thr tcc acg agc Ser Thr Ser aat gac ata Asn Asp Ile gtc gac ggc Val Asp Gly ttc aqt ctq tct acg Phe Ser Leu Ser Thr cga aat ctc tat gca Arg Asn Leu Tyr Ala act gca cat gcc gct Thr Ala His Ala Ala 45 tgg ttg Trp Leu 15 gta gtt Val Val 30 ggt tgc Gly Cys ctcttcctta aaagtgcact gtg atc gaa gaa tat Val Ile Glu Glu Tyr 1 tcc cca cgc ata cga Ser Pro Arg Ile Arg atc gcc gat gag att Ile Ala Asp Glu Ile act gcc aaa atc gaa Thr Ala Lys Ile Glu gag att Glu Ile ctc gat gcc tat Leu Asp Ala Tyr gaa Giu att gcg gtt ctt Ile Ala Val Leu gca cca caa caa Ala Pro Gin Gin cy c Arg ttc aac aca gat Phe Asn Thr Asp ctt Le u 75 gtt tta caa gct Val Leu Gin Ala tat T yr 80 ggt gaa act gcc Gly Giu. Thr Ala cga Arg cgc tgt gat ttc Arg Cys Asp Phe caa gag cat gta Gin Glu His Val gcc ttc ttt gca Ala Phe Phe Ala tca atg Ser Met 100 cgt aag gac Arg Lys Asp tat gtc tat Tyr Val Tyr 120 ct c Le u 105 aaa gct aat aca Lys Ala Asn Thr cac His 110 gac cca gat aga Asp Pro Asp Ser ttc aca acg Phe Thr Thr 115 ctc agc gtt Leu Ser Val ggc tcc gcg gaa Gly Ser Ala Giu ata ggc ctq ctt Ile Gly Leu Leu ttc aac Phe Asn 135 caa ggt aga acg Gin Gly Arg Thr att Ile 140 agc aaa aaa cgg Ser Lys Lys Arg gag att atg caa Glu Ile Met Gin gga gcc cgc tca Gly Ala Arg Ser gga gcg gca ttc Gly Ala Ala Phe aaa att aac: ttt Lys Ile Asn Phe cgt gac ttg gca Arg Asp Leu Ala gaa Glu 170 gat cag caa aat Asp-Gln Gin Asn ggc cga ttt tat Gly Arg Phe Tyr ttc ccc: Phe Pro 180 aaa acc agc Lys Thr Ser gct gat atc Ala Asp Ile 200 gga act ctt act Gly Thr Leu Thr qaa caa aaa gaa Giu Gin Lys Giu gat ctc atc Asp Leu Ile 195 ttt cca qaa Phe Pro Glu cgt caa gac cta Arg Gin Asp Leu att gcc cac gat Ile Ala His Asp gca Ala 210 ata cca Ile Pro 215 gtg cag gct cgc Val Gin Ala Arg gga gtg atc tct Gly Val Ile Ser tat ttg ctc ttt Tyr Leu Leu Phe ca a Gin 230 aaa ctc act gac Lys Leu Thr Asp att gag gct act Ile Giu Ala Thr acc gcc gat tta Thr Ala Asp Leu 787 835 883 cgg gag cga atc Arg Giu Arg Ile gtt cca ctt cat Val Pro Leu His atc Ile 255 aaa ctc tct aca Lys Leu Ser Thr ctc gct Leu Ala 260 aga gcc acg Arg Ala Thr atg Met 265 aaa ggt cta tct Lys Gly Leu Ser agc atc tac aga Ser Ile Tyr Arg aag aat tcg Lys Asn Ser 275 tgatgaaggt ctcgactaaa act <210> 266 <211> 277 <z212> PRT <213> Corynebacterium glutamicum <400> 266 Val Ile Glu Glu Tyr Ser Thr Ser Phe Ser Leu Ser Thr 1 Se r Ile Thr Ala Gly Phe Asp Leu Leu Lys Arq Lys Asp Ala 225 Thr Leu Tyr Pro Al a Ala Ala Glu Phe Ser Cys 130 Glu Ile Phe Gl u Al a 210 Tyr Ala Se r Arg Arg Asp L ys Pro Thr Ala Phe 115 Leu Ile As n Tyr Asp 195 Phe Leu Asp Thr Lys 27 Ile Glu Ile Gin Al a Ser 100 Thr Ser Met Phe Phe 180 Le u Pro Le u Leu Le u 260 As n 5 Arg Ile Glu Gin Arg Met Thr Val1 Gin Leu 165 Pro Ile Giu Phe Leu 245 Al a Se r Asn Val1 Giu Ar g 70 Arg Arg Tyr Ph e As n 150 Arg Lys Al a Ile Gin 230 Arg Arg Asp Asp Ile 55 Phe Cys Lys Val Asn 135 Gly Asp Thr Asp Pro 215 L ys Giu Ala Ile Gly 40 Leu Asn Asp As p Tyr 120 Gin Ala Le u Ser .I le 200 Val Leu Arg Thr 10 As n Ala Al a Asp Glu 90 Lys Ser Arg Ser Glu 170 Gly Gin Ala Asp Arg 250 Lys Leu His T yr Le u 75 Gin Aila Ala Thr Leu 155 Asp Thr Asp Arg Arg 235 Vali Gly Tyr Ala Gin Val1 Gin As n Giu Ile 140 Gly Gin Leu Leu Ile 220 Ile Pro Leu Al a Ala Ile Leu His Thr Val1 125 Ser Ala Gin Thr Ala 205 Gly Glu Leu Ser Trp Val Gly Ala Gin Val1 His 110 Ile Lys Aia As n Lys 190 Ile Val1 Aia His Met 270 Leu Val1 Cys Val1 Ala Ile Asp Gly Lys Phe Leu 175 Giu Ala Ile Thr Ile 255 Ser Leu Arg Ser Leu Tyr Al a Pro Le u Arg Gin 160 Gl y Gin His Ser Pro 240 Lys Ile <210> 267 <211> 1056 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(1033) <223> RXA01291 <400> 267 aacccgcagc gggtggagcg gggctgaggg agacgtcgag tgqatttctc gcggtaaaqt ttcctgtgaa ggaggcgagt aagcgtccct ttcggttgtc gat Asp gta Val1 t cq Ser gtg Val1 ccg Pro ctc Leu gg9C Gly ttt Phe act Thr atg Met 150 cgg Arg aag Lys ttt Phe atc Ile ccg Pro gcc Ala gac Asp agt Ser aat As n ttt Phe cag Gin 135 t gt Cys gcC Ala gta Val1 t tg Leu gcc Ala aaa Lys gat Asp gcC Ala ttg Leu acc Thr gat Asp 120 ttg Leu ttg Leu acq Thr aat Asn ggc Gly cat His att Ile gag Glu gtt Val1 t cc Ser gcC Ala 105 t cc Ser gat Asp aaa Lys atg Met ttc Phe ga t Asp tcC Ser ga t Asp ga c Asp 60 att Ile ttt Phe tgt Cys cgc Arg att Ile 140 ctc Leu ggc Gly ga t Asp atg Met ttt Phe 30 gag Glu gct Ala gac Asp acc Thr ttt Phe 110 ctc Le u ggC Gi y ga t Asp ag Arg qct Al a agc Ser act Thr. gca Al a gct Ala aat Asn gat Asp gag Giu tcc Ser tcc Se r t cc Ser cgt Arg 175 qaa Glu t ca Se r ctq Leu ttg Leu gct Al a tac Tyr 80 cca Pro cag Gin ca a Gin gc t Al a act Thr 160 ttg Le u gac Asp qtg Val 1 aag Lys qca Ala tac T yr gc Ala gaa Giu gtg Val1 gct Ala acc Thr gag Giu 145 g cc Ala ggt Gly cgc Arg gct gat cag caa Asp acg Thr aag Lys atg Met ggg Gi y cag Gin cat His atc Ile 115 tat Tyr atc Ile ccg Pro gca Ala 9gC Gly Gin gjc C Ala ctg Leu gtg ValI t gt Cys gtt Val gcg Ala 100 gtg Val gat Asp ggg Gly cag Gin ttt Phe 180 cta Leu Gin acg Thr ttg Le u cga Arg gcg Al a ct g Le u ttt Phe gcg Al a ccg Pro ttg Leu ga t Asp 165 caa Gin ggc Gly 115 163 211 259 307 355 403 451 499 547 595 643 691 185 190 195 cgt tct tat ttg cog gta ttc aco gaa gaa atg cgc gat gag atc gtt 739 Arg Ser Tyr Leu Pro Val Phe Thr Glu Giu Met Arg Asp Glu Ile Val 200 205 210 act gat ato cga gag gat ttq gat goc gcc cgg ctg agc att cog ctg 787 Thr Asp Ile Arg Glu Asp Leu Asp Ala Ala Arg Leu Ser Ile Pro Leu 215 220 225 ctg cca ttt ggc gcg cga acc ggt gtg cgc goc gcg acc gat oto tac 835 Leu Pro Phe Gly Ala Arq Thr Gly Val Arg Ala Ala Thr Asp Leu Tyr 230 235 240 245 ggt tgo oto gtg gac aac ctg gaa too gog too ctc gaa gac tta aaa 883 Gly Cys Leu Val Asp Asn Leu Glu Ser Ala Ser Leu Glu Asp Leu Lys 250 255 260 aac ggg cgg gat ttt qtg ccg tot tta aaa aag cca gcc tgg caa coa 931 Asn Gly Arg Asp Phe Val Pro Ser Leu Lys Lys Pro Ala Trp Gin Pro 265 270 275 aag caa tgt gga aag aag tgt tto aaa aat gac aaa ago agt ggt oat 979 Lys Gin Cys Gly Lys Lys Cys Phe Lys Asn Asp Lys Ser Ser Gly His 280 285 290 ogg cgg ggg act ago agg act ago cac cac ogo act got ctt acg oga 1027 Arg Arg Gly Thr Ser Arg Thr Ser His His Arg Thr Ala Leu Thr Arg 295 300 305 agg ata tgaagtccac otogtogaao aaa 1056 Arg Ile 310 <210> 268 <211> 311 <212> PRT <213> Corynebacterium glutamioum <400> 268 Val Ala Asp Gin Gin Asp Phe Leu Gly Arg Phe Asp Ala Met Ser Ser 1 5 10 Lys Ala Thr Ala Thr Val Ile Ala His Tyr Ser Ser Ser Phe Thr Leu 25 Ala Ser Lys Leu Leu Ser Pro Lys Ile Arg Arg Asp Ile Glu Ala Leu 40 Tyr Ala Met Val Arg Val Ala Asp Glu Val Val Asp Gly Ala Ala Ala 55 Ala Ala Gly Cys Ala Pro Asp Ala Val Ala Glu Ile Leu Asp Asn Tyr 70 75 Glu Arg Gin Val Leu Leu Ser Leu Ser Val Pro Phe His Thr Asp Pro 90 Val Ile His Ala Phe Gly Asn Thr Ala Arg Lys Cys Gly Phe Glu Gln 100 105 110 Ala His Ile Val Ala Phe Phe Asp Ser Met Arg Arg Asp Leu Ser Gln 115 120 125 Thr Ser Tyr Asp Pro Thr Gin Leu Asp Giu Tyr Ile Tyr Gly Ser Ala 130 135 140 Glu Val Ile Gly Leu Met Cys Leu Lys Ile Phe Leu Gin Asp Ser Thr 145 150 155 160 Ala Ser Pro Gin Asp Arg Ala Thr Met Glu His Gly Ala Arg Arg Leu 165 170 175 Gly Ala Ala Phe Gin Lys Val Asn Phe Leu Arq Asp Leu Ala Glu Asp 180 185 190 Arq Glu Gly Leu Gly Arg Ser Tyr Leu Pro Val Phe Thr Giu Glu Met 195 200 205 Arq Asp Giu Ile Val Thr Asp Ile Arg Giu Asp Leu Asp Ala Ala Arg 210 215 220 Leu Ser Ile Pro Leu Leu Pro Phe Gly Ala Arg Thr Gly Val Arg Ala 225 230 235 240 Ala Thr Asp Leu Tyr Gly Cys Leu Val Asp Asn Leu Giu Ser Ala Ser 245 250 255 Leu Giu Asp Leu Lys Asn Gly Arg Asp Phe Val Pro Ser Leu Lys Lys 260 265 270 Pro Ala Trp Gin Pro Lys Gin Cys Gly Lys Lys Cys Phe Lys Asn Asp 275 280 285 Lys Ser Ser Gly His Arg Arg Gly Thr Ser Arg Thr Ser His His Arg 290 295 300 Thr Ala Leu Thr Arg Arg Ile 305 310 <210> 269 <211> 1239 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1216) <223> RXA00480 <400> 269 tttatggacc caaattcaca ctttctgtac ttcatcaaaa taaagcgcca tatacaacga ttgggaattt ttgcgagata actggccqtg tgatactcga atg gac aat ggc atg 115 Met Asp Asn Gly Met 1 aca atc acc aca gaa cat tca act cat cct gat ctt gat ttc aat gat 163 Thr Ilie Thr Thr Glu His Ser Thr His Pro Asp Leu Asp Phe Asn Asp 15 gag att tat Glu Ile Tyr tgc age aca Cys Ser Thr gaa eta aac cgc Giu Leu Asn Arg tgc get teg cta Cys Ala Ser Leu tct caa cag Ser Gin Gin get get tte Aia Aia Phe 211 259 tat caa cca gag Tyr Gin Pro Glu ttc Phe cgt ace tgc eta Arg Thr Cys Leu caa get Gin Ala ttg cga ggt ggc Leu Arg Giy Gly tta ate cgc cct Leu Ile Arg Pro cga Arg atg eta ctg ggg Met Leu Leu Gly tac aac acg ctt Tyr Asn Thr Leu gta Val1 gac: gat gac att Asp Asp Asp Ile gtc aaa etc aac Val Lys Leu Asn gtt tta eag gta Val Leu Gin Val gtg get tta gaa Vai Ala Leu Giu etg eat ttt tc Leo His Phe Ser ett ttg Leu Leo 100 gtt cat gac Vai His Asp aat ttt att Asn Phe Ile 120 gtt att gac gga Vai Ile Asp Giy gac Asp 110 etc tat cge ega Leo Tyr Arg Arg ggc aaa ett Gly Lys Leu 115 agt ttt gca Ser Phe Ala ggg cag att etc: Giy Gin Ilie Leu eat cgc aea cet His Arg Thr Pro eaa ate Gin Ile 135 cag cgc gat cca Gin Arg Asp Pro cat eta gat tgg His Leo Asp Trp gea Al a 145 eaa tet aat gga Gin Ser Asn Gly ctg Leu 150 ctt atg gga aat Leu Met Gly Asn ott Leu 155 ttt ctt get gee Phe Leu Ala Ala eat caa ate tte His Gin Ile Phe 547 595 643 egc ett gae ott Arg Leu Asp Leo eat eae caa egg His His Gin Arg ega ctt tta gat Arg Leo Leo Asp tta etc: Leu Leu 180 aac cac aeg Asn His Thr tta age age Leu Ser Ser 200 ata Ile 185 aat gao: act att Asn Asp Thr Ile gt g Val1 190 ggt gag ttt ett Gly Glu Phe Leu gat gtg gga Asp Val Gly 195 eta gaa atg Leu Glu Met aaa gee ate: age Lys Ala Ile Ser aat atg gac att Asn Met Asp Ile agt egg Ser Arg 215 eta aaa aca gee Leo Lys Thr Ala aca Thr 220 tao act ttt gaa Tyr Thr Phe Giu ott Leo 225 oca atg aga gca Pro Met Arg Ala g eg Ala 230 gca att etc geg Ala Ilie Leu Ala gaa Glu 235 eta cot cag gag Leo Pro Gin Glu gaa aca aag ata Gbu Thr Lys Ile 787 835 883 gag ata ggc aca Giu Ile Gly Thr ttg ggc ate get Leo Giy Ile Ala caa ttg cag gac Gin Leu Gin Asp gat tao Asp Tyr 260 tta tct act ttt ggt gac gca gcc gaa cac ggc aaa gat gcc ttt tot 931 Leu Ser Thr Phe Gly Asp Ala Ala Glu His Gly Lys Asp Ala Phe Ser 265 270 275 gac ctt cga gaa gga aaa gaa act aca att atc gcc tto gct cga gat 979 Asp Leu Arg Giu Gly Lys Glu Thr Thr Ile Ile Ala Phe Ala Arg Asp 260 285 290 act gct aaa tgg act gat att caa gac aac ttc ggc tcc gca gat ctg 1027 Thr Ala Lys Trp Thr Asp Ile Gin Asp Asn Phe Giy Ser Ala Asp Leu 295 300 305 ago acc tct cag gca gag cga att caa cat ott ctc ata cag tgt gga 1075 Ser Thr Ser Gin Ala Glu Arg Ile Gin His Leu Leu Ile Gin Cys Gly 310 315 320 325 gca aaq aat cac tcc ttg aat goc atc tcc gac cac tta aat atc tgc 1123 Ala Lys Asn His Ser Leu Asn Ala Ile Ser Asp His Leu Asn Ile Cys 330 335 340 cgt tcg atg atc aaa aca cta agc ccc cag gta gat ccc aag got caa 1171 Arg Ser Met Ile Lys Thr Leu Ser Pro Gin Val Asp Pro Lys Ala Gin 345 350 355 aat tta tta ctt aaa caa gtt gag caa cta gcc agc cgc aaa tct 1216 Asn Leu Leu Leu Lys Gin Val Glu Gin Leu Ala Ser Arg Lys Ser 360 365 370 tagaactaac ctttacgcct tta 1239 <210> 270 <211> 372 <212> PRT <213> Corynebacterium giutamicum <400> 270 Met Asp Asn Gly Met Thr Ile Thr Thr Giu His Ser Thr His Pro Asp 1 5 10 Leu Asp Phe Asn Asp Glu Ile Tyr Arg Giu Leu Asn Arg Ile Cys Ala 25 Ser Leu Ser Gin Gin Cys Ser Thr Tyr Gin Pro Glu Phe Arg Thr Cys 40 Leu Asp Ala Ala Phe Gin Ala Leu Arg Gly Gly Lys Leu Ile Arg Pro 55 Arg Met Leu Leu Gly Leu Tyr Asn Thr Leu Val Asp Asp Asp Ile Giu 70 75 Val Lys Leu Asn Thr Val Leu Gin Val Ala Val Ala Leu Glu Leu Leu 90 His Phe Ser Leu Leu Val His Asp Asp Val Ile Asp Giy Asp Leu Tyr 100 105 110 Arg Arg Gly Lys Leu Asn Phe Ile Gly Gin Ile Leu Met His Arg Thr 115 120 125 Pro Giu Ser Phe Ala Gin Ile Gin Arg Asp Pro Glu His Leu Asp Trp 130 135 140 Ala Gin Ser Asn Giy Leu Leu Met Gly Asn Leu Phe Leu Ala Ala Thr 145 150 155 160 His Gin Ile Phe Ala Arg Leu Asp Leu Pro His His Gin Arg Val Arg 165 170 175 Leu Leu Asp Leu Leu Asn His Thr Ile Asn Asp Thr Ile Val Giy Giu 180 185 190 Phe Leu Asp Val Giy Leu Ser Ser Lys Ala Ile Ser Pro Asn Met Asp 195 200 205 Ile Ala Leu Giu Met Ser Arg Leu Lys Thr Ala Thr Tyr Thr Phe Giu 210 215 220 Leu Pro Met Arg Ala Ala Ala Ile Leu Ala Giu Leu Pro Gin Giu Ile 225 230 235 240 Giu Thr Lys Ile Gly Glu Ile Giy Thr Asn Leu Gly Ile Ala Tyr Gin 245 250 255 Leu Gin Asp Asp Tyr Leu Ser Thr Phe Gly Asp Ala Ala Giu His Gly 260 265 270 Lys Asp Ala Phe Ser Asp Leu Arg Giu Gly Lys Giu Thr Thr Ile Ile 275 280 285 Ala Phe Ala Arq Asp Thr Ala Lys Trp Thr Asp Ile Gin Asp Asn Phe 290 295 300 Giy Ser Ala Asp Leu Ser Thr Ser Gin Ala Giu Arg Ile Gln His Leu 305 310 315 320 Leu Ile Gin Cys Gly Ala Lys Asn His Ser Leu Asn Ala Ile Ser Asp 325 330 335 His Leu Asn Ile Cys Arg Ser Met Ile Lys Thr Leu Ser Pro Gin Val 340 345 350 Asp Pro Lys Ala Gin Asn Leu Leu Leu Lys Gin Val Glu Gin Leu Ala 355 360 365 Ser Arg Lys Ser 370 <210> 271 211> 1056 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDs <222> (101)..(1033) <223> RXS01879 (400> 271 ctttgcgggc cgctgatatt gatccaacgc ttcgtggcga aaagcttgat gtcactqact atgtgcgcct agctggggtg ttgcagcaaa aggatgagaa aaat ac gt 15 aaa att acc gct 115 Lys Ile Thr Al a aag gcg tgg gcg Lys Ala Trp Ala acc aac ctg cat Thr Asn Leu His tta Leu ggt gtg gga ccg Gly Val Gly Pro gct cac Ala His gac gat gga Asp Asp Gly ttt gac acc: Phe Asp Thr cac gag ctc atg His Glu Leu Met gtg ttt caa acc Val Phe Gin Thr att gat ctg Ile Asp Leu gtg gag gag Val Giu Glu 211 259 gtc acc tta acc Vai Thr Leu Thr acc Thr ctc gat gag gag Leu Asp Glu Giu ggg agc: Gly Ser gtc gtc aag caa Val Val Lys Gin tct gtg acc ggt Ser Val Thr Giy cgt ggC gtg cct Arg Giy Val Pro gag Giu gac gcc agc aat Asp Ala Ser Asn ctt Leu 75 gcg tgg cgc get Ala Trp Arg Ala gat gcg ttg gtt Asp Ala Leu Val aag Lys egg cgc gcg gaa Arg Arg Ala Glu acg ccg ctg tct Thr Pro Leu Ser gca Ala gtt tcg.ctg cat Val Ser Leu His att tcc Ile Ser 100 aag ggg att Lys Gly Ile get gcg aca Ala Ala Thr 120 gtg gct ggc ggc Val Ala Gly Gly gct ggc ggc tct Ala Gly Gly Ser gcg gat gcg Ala Asp Ala 115 ttc ggc gag Phe Gly Giu 451 499 ctg cgc gca gtg Leu Arg Ala Val gat Asp 125 gcc tgg att ggg Ala Trp Ile Giy gac aca Asp Thr 135 ttg ctg gag gtt Leu Leu Giu Val gcc Ala 140 gcg gag ctc ggc Ala Giu Leu Gly gat gtg ccg ttt Asp Val Pro Phe t gc Cys 150 ctg ctt ggt gge Leu Leu Gly Gly acc Thr 155 atg cgc ggt acc Met Arg Gly Thr cgc ggc gag cag Arg Gly Giu Gin ct g Le u 165 547 595 643 gta gat atg ttg Val Asp Met Leu cgc ggc aag cta Arg Gly Lys Leu cat His 175 tgg gtg gtg gcc Trp Val Val Ala geg atg Ala Met 180 gcg cat ggc Ala His Gly aat ccg gaa Asn Pro Giu 200 tcc acg cct gag Ser Thr Pro Giu ttc aaa aag cat Phe Lys Lys His gat gag ctg Asp Giu Leu 195 gca ctt ctc Ala Leu Leu 691 739 tcg cat atg gat Ser His Met Asp atc Ile 205 agc gac etc agc Ser Asp Leu Ser gcc Al a 210 acc ggc Thr Gly 215 aac ace gcc gag Asn Thr Ala Glu ggg eag tgg ctg Gly Gin Trp Leu aat gat etg ace Asn Asp Leu Thr agc gcc gca ctc agt ttg cgc cct gaa Ser Ala Ala Leu Ser Leu Arg Pro Glu 230 235 ggc atc cgc tcc ggc gcg cat gca gga Gly Ile Arg Ser Gly Ala His Ala Gly 250 acc acg gta ttc ttg tgc gaa tcg gag Thr Thr Val Phe Leu Cys Glu Ser Glu 265 270 gag gcq cta atc gac gcc ggc cag gtg Glu Ala Leu Ile Asp Ala Gly Gln Val 280 285 ggc cct gcg gcc tca acc gcc gac cag Gly Pro Ala Ala Ser Thr Ala Asp Gln 295 300 gtt tca taataaagac aaacttaagt atc Val Ser 310 <210> 272 <211> 311 <212> PRT <213> Corynebacterium glutamicum <400> 272 Val Lys Ile Thr Ala Lys Ala Trp Ala cgc Arg 240 gtc Val aaa Lys gct Al a ggc Gly gtc Val ggc Gly caa Gln tac T yr 290 cac His ctc Le u toc Ser gac Asp 275 acc Thr att Ile gaa Gl u 245 ccg Pro aaa Lys acc Thr act Thr 835 883 931 979 1027 1056 1 Val1 Gln Glu Ala Asp Ser Gly Gly Ser 145 Gly Thr Leu Arg Ala Leu Ser Pro 130 Asp Pro Ile Val1 Gly Le u His Ala 115 Phe Val1 Al a Asp Glu Val1 Val1 Ile 100 Asp Gly Pro Asp Phe Gly Giu 70 Arg Lys Ala Asp Cys 150 Asp Asp Ser Asp Arg Gly Al a Thr 135 Leu Gly Thr 40 Val1 Al a Al a Ile Thr 120 Leu Le u Phe 25 Val1 Val1 Ser Glu Pro 105 Leu Le u Gi y Th r Glu Leu Gin Le u 75 Th r Ala Ala ValI Thr 155 Leu Met Thr Ser Trp Le u Gly Asp 125 Al a Arg His Thr Le u Val1 Ar g Ser Met 110 Al a Glu Gl y Gly Phe Glu Gly Val1 Val1 Gly Ile Gi y Gly 160 Arg Val2 Lys Ser His 225 Ser Ser Al a Al a Al a 305 Gly Val1 His Ala 210 Asn Val Gly Gin T yr 290 His Glu Al a Asp 195 Al a Asp Leu Ser Asp 275 Thr Ile Gin Al a 180 Glu Leu Leu Gin Gly 260 Val1 Al a Leu be u 165 Met be u Leu Thr Glu 245 Pro Lys Thr Thr Val1 Ala As n Thr Ser 230 Gly Thr Glu Gly Val 310 Thr 170 Ser His Al a Ser Gly 250 be u Asp Ser Gly Pro Asp Val 220 Arg His Glu Gly Ala 300 Lys Gl u Ile 205 Gi y Pro Al a Se r Gin 285 Asp be u ValI 190 Se r Gin Glu Gly Glu 270 Val1 Gin His 175 Phe Asp Trp beu Ile 255 His Tyr Arg <210> 273 <211> 891 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (868) <223> RXS02023 <400> 273 gatgtggcag caattttgaa gcagtacctg agcgagtaac gacttccgaa atgtaactag agactagagg aggaaacacg act T hr cgt Arg gct Al a cag ccc Pro cgg Arg gat Asp t ct agc Ser cag Gin cac His gag gag Glu gag Glu t gg Trp gtg aag Lys gg C Gly aag Lys gCg aac Asn gat Asp ga t Asp gatC cgcattcggg gttatcgtgg atg gct cct aaa caa Met Aia Pro Lys Gin 1 gga cca gtt ctg caa Gly Pro Val beu Gin ttg cta gaa atg cgc beu beu Glu Met Arg cgt gta ctg cgt att Arg Val Leu Arg Ile cac gag atg cca aag Gin Ser Giu ?he Val Ala Gly Phe Asp Ala Leu His Glu Met Pro Lys gee Al a tac Tyr gta ace gtc ttt Val Thr Val The aag gcg ggt gta Lys Ala Gly Val qgt Gly tce gca cgc att Ser Ala Arg Ile gag gat cac ccg Giu Asp His Pro gaa ett ggt gaa Giu Leu Gly Glu ctc gtt gca gcg Leu Val Ala Ala gac: tac Asp Tyr 100 gea gtt gtc Ala Val Val ggg gca age Gly Ala Ser 120 ggt ggc ggt eca, Gly Gly Gly Pro ggt Gly 110 etg atg gaa gee Leu Met Giu Ala eec aat aag Pro Asn Lys 115 att gag ttg Ile Giu Leu gag gee aat ggt Glu Ala Asn Gly tea gtt ggt ctg Ser Val Gly Leu eea eat Pro His 135 gaa eag eat etg Giu Gin His Leu aac Asn 140 ect tat gtg gat Pro Tyr Val Asp ttg Le u 145 ggt etg aae tte Gly Leu Asn Phe tac ttc tte gea Tyr Phe Phe Ala ege aag Arg Lys 155. ace atg tte Thr Met Phe aaa tac tee cag Lys Tyr Ser Gin ttt gtg tgt etg Phe Val Cys Leu ect Pro 170 ggt ggt tte gge Gly Gly Phe Gly a eg Thr 175 etc gat gag ett Leu Asp Glu Leu tte gag Phe Giu 180 gtC Cc tgc Vai Leu Cys etg ate gge Leu Ile Giy 200 gta eaa acc ggc Val Gin Thr Gly gta ccc aac ttt Val Pro Asn Phe ccc ate gtg Pro Ile Val 195 ate cgt cac Ile Arg His act gag tte tgg Thr Glu Phe Trp ggt ttg qtg gat Gly Leu Val Asp ege etg Arg Leu 215 gta gag gaa gge Val Giu Giu Giy atg Met 220 ate gat gag aag Ile Asp Giu Lys ga t Asp 225 gtt gac egg atg Val Asp Arg Met gte act gat gac Val Thr Asp Asp gat cag gee gte Asp Gin Ala Vai tte ate gte gat Phe Ile Val Asp cac get gga ttg His Ala Giy Leu gac Asp 250 gta geg egt etc Val Aia Arg Leu cac aat His Asn 255 taagcagtgg ctacattagg 888 <210> 274 <211> 256 <212> PRT <213> Corynebacterium glutamicum <400> 274 Met Ala Pro Lys Gin Thr Pro Ser Pro Giu Lys Asn Arg Asn Leu Vai 1 Gi y Leu Arg His Giu Val1 Glu Leu Leu 145 Lys Asp As n Asp Asp 225 Pro Val Leu Glu Val Leu Glu Met Asp His Ala Ala Ala Pro 115 Gly Ile 130 Gly Leu Tyr Ser Glu Leu Phe Pro 195 Trp Ile 210 Val Asp Leu Gin Met Arg Arg Ile Pro Lys Pro Tyr Asp Tyr 100 Asn Lys Glu Leu Asn Phe Gin Ala 165 Phe Glu 180 Ile Val Arg His Arg Met Arg Ala Gin Ala 70 Tyr Ala Gi y Pro Ar g 150 Phe Val1 Leu Arg Leu 230 Arg Asp Ser 55 Val1 Lys Val Ala His 135 Tyr Val1 Leu Ile Leu 215 Val1 Gin His 40 Glu Thr Al a Val1 Ser 120 Glu Phe C ys Cys Gly 200 Val1 Thr Thr 25 As n Phe Va i Gi y Thr 105 Giu Gin Phe Leu Met 185 Thr Gi u Asp Glu T rp ValI Phe Val1 90 Gi y Al a His Al a Pro 170 Val1 Glu Glu Asp Gly Lys Ala Gly 75 Glu Gly Asn Le u Arg 155 Gly Gin Phe Gi y Leu 235 Thr Phe Asp Gin Arg His Gly Ser Leu Gly Gly Asn 140 Lys Gly Thr Trp Met 220 Asp Ala Phe Ala Gi y Pro Le u 125 Pro Thr Phe Gly Al a 205 Ile Gin Asp Asp Arg Glu Gly 110 Ser Tyr Met Gi y Lys 190 Gi y Asp Al a Pro Al a Ile Lys Leu Val Val Phe Thr 175 Val Leu Glu Val Trp Leu Lys Le u Met Gly Asp Le u 160 Leu Pro Val1 Lys Lys 240 Phe Ile Val Asp Ala His Ala Gly Leu Asp Val Ala Arg Leu His Asn 245 250 2 <210> 275 <211> 1242 <212> DNA <213> Corynebacterium glutamicumn <220> <221> CDS <222> (101)..(1219) <223> RXS00948 <400> 275 acacccteca aatgatctcg taaaacagta ttgaatttag tgccctcaag ccaagctagt tgtacgatca aactcgttgt. gtaegaetet aategtacet atg gca aac gtc gta il! Met Ala Asn Val Val eta gte gat cga atg gag cet. ttg gtg Leu Vai Asp Arg Met Giu Pro Leu Val aag ctg ttt. acc Lys Leu Phe Thr cca att. Pro Ile caa atc cgc Gin Ilie Arg tgc ace tac Cys Thr Tyr gac Asp ate acc ate ccc Ile Thr Ile Pro ege gtg tgg atg Arg Vai Trp Met tea ceg atg Ser Pro Met gat ttt cac Asp Phe His tet gea gee ac Ser Aia Ala Thr gg t Gi y tca ggt ctt ccc Ser Giy Leu Pro eag get. Gin Ala eat tac gca get His Tyr Ala Ala ego Arg 60 gca gca qgt ggt Aia Ala Giy Giy gte Val1 qqa tta gte atg Giy Leu Val Met gaa gea act gga Glu Ala Thr Gly aac ce gta gct Asn Pro Vai Ala ate tee cca gte Ile Ser Pro Val ott gga ott tgg Leu Giy Leu Trp age Se r cat gao caa att His Asp Gin Ile oca ttc tee ega Pro Phe Ser Arg gtg aca Vai Thr 100 gea get att, Ala Ala Ile get gge ego Ala Gly Arg 120 gee ggt ggg gca Ala Gly Gly Ala gta Val 110 cog gee gtt eaa Pro Ala Val Gln tta gee cat Leu Ala His 115 ggc gga tat Gly Giy Tyr aag gea tee ace Lys Ala Ser Thr got cog tgg aat Ala Pro Trp Asn gtt gga Val Gly 135 oca gaa ace aat Pro Giu Thr Asn gga Gly 140 tgg gag act gte Trp Giu Thr Val ggo Gi y 145 eec ago cot ctg Pro Ser Pro Leu gca Al a 150 ttc eca ggt ttg Phe Pro Gly Leu get cog ego gag Ala Pro Arg Glu aeg gtt tea gaa Thr Val Ser Giu ate Ile 165 caa gag gtt gtg Gin Glu Val Val cag Gin 170 cag tte get gge Gin Phe Ala Gly gee gtt ogt gee Ala Val Arg Ala gat cag Asp Gin 180 got ggt ttt Ala Gly Phe cat aac tto His Asn Phe 200 gte gtg gaa att Val Val Giu Ile cac His 190 gca gca cac ggc Ala Ala His Gly tao ott ttg Tyr Leu Leu 195 tea tao ggc Ser Tyr Gly ott tot cog ate Leu Ser Pro Ile aao aag ego ace Asn Lys Arg Thr gga tet tta gaa aac ego got ego ate gtg oto gaa gte att gat gca Gly Ser Leu Giu Asn Arg Ala Arg Ile Val Leu Giu Val Ile Asp Ala 220 225 ate Ile 230 ego gca gtg tgq Arg Ala Val Trp cca Pro 235 gag gaa aag cot Giu Giu Lys Pro tte atg cgc att Phe Met Arg Ile 835 883 acc acc gac tgg Thr Thr Asp Trp gag gaa aac oca Glu Giu Asn Pro gat gat cgc gag Asp Asp Arg Glu tcc tg Ser Trp 260 acg ctg agc Thr Leu Ser qtt gat ttg Val Asp Leu 280 caa. Gin 265 agc agq cag ctq Ser Arg. Gin Leu ttq tgg gca tcc Leu Trp Ala Ser gag cac gga Giu His Gly 275 gte ccc att Val Pro Ile 931 979 ate gat gee tct Ile Asp Ala Ser ggt ggc etc gac Gly Gly Leu Asp ccg oat Pro His 295 gac cgc gat tac Asp Arg Asp Tyr caa Gin 300 ace gcg aag gee Thr Ala Lys Ala gat ott cac gca Asp Leu His Ala ace gga gtg aca Thr Gly Vai Thr get get gtg ggg Ala Ala Val Gly att gat gao gc Ile Asp Asp Ala caa Gin 325 1027 1075 1123 act gcg cac aat Thr Ala His Asn ttg Le u 330 gtt gat tot ggc Val Asp Ser Gly gat Asp 335 gte aat gca gtt Val Asn Ala Val tte etc Phe Leu 340 ggc ogt eca Gly Arg Pro qoa eta qgt Ala Leu Gly 360 etc aag gat ect Leu Lys Asp Pro tgg gca aae caa Trp Ala Asn Gin goa gee etc Ala Ala Leu 355 tac gta ctt Tyr Val Leu 1171 1219 gog gaa 000 agq Ala Giu Pro Arg tat Tyr 365 gtt eac oaa tao Val His Gin Tyr gao Asp 370 taaaggagag ttgacatgaa ggt <210> 276 <211> 373 <212> PRT <213> Corynebacterium glutamioum <400> 276 Met Ala Asn Val Val Leu Val Asp Arg Met 1 5 10 1242 Glu Pro Leu Val Ser Lys Leu Phe Thr Pro Ile Gin Ile Arg Asp 25 Trp Met Ser Pro Met Cys Thr Tyr Ser 40 Ile Thr Ile Pro Asn Arg Val Ser Gly Leu Ala Ala Thr Gly Pro Thr Asp Phe His Gin Ala His Tyr Ala Ala Arg 55 Val Gly Leu Val Met Val Giu Ala Thr Gly Val Asn 70 75 Ala Ala Gly Gly Pro Val Ala Pro Ile Ser Pro Val Asp Leu Gly Leu Trp Ser His Asp Gin Ile Glu Pro Phe Ser Arg Val Thr 100 Val Gin Leu Ala His 115 Asn Gly Gly Gly Tyr 130 Gly Pro Ser Pro Leu 145 Thr Val Ser Glu Ile 165 Val Arg Ala Asp Gin 180 His Gly Tyr Leu Leu 195 Thr Asp Ser Tyr Gly 210 Glu Val Ile Asp Ala 225 Phe Met Arg Ile Ser 245 Asp Arg Glu Ser Trp 260 Ala Ser Glu His Gly 275 Asp Ile Val Pro Ile 290 Ala Asp Leu His Ala 305 Ile Asp Asp Ala Gin 325 Asn Ala Val Phe Leu 340 Asn Gin Ala Ala Leu 355 Tyr Asp Tyr Val Leu 370 <210> 277 <211> 1026 90 Ala Gly Gly 135 Phe Glu Gly Asn Ser 215 Arg Thr Leu Asp His 295 Thr Ala Arg Ile Arg 120 Pro Pro Val Phe Phe 200 Leu Ala Asp Ser Leu 280 Asp Gly His Pro Arg 105 Lys Glu Gly Val Asp 185 Leu Glu Val Trp Gin 265 Ile Arg Val Asn Leu 345 Gly Ser Asn Pro 155 Gin Val Pro Arg Pro 235 Glu Arg Ala Tyr Val 315 Val Lys Gly Thr Gly 140 Ala Phe Glu Ile Ala 220 Glu Glu Gin Ser Gin 300 Ala Asp Asp Ala Asp 125 Trp Pro Ala Ile Ser 205 Arg Glu Asn Leu Ser 285 Thr Ala Ser Pro Val 110 Ala Glu Arg Gly His 190 Asn Ile Lys Pro Ala 270 Gly Ala Val Gly Ser 350 Pro Pro Thr Glu Ala 175 Ala Lys Val Pro Gin 255 Leu Gly Lys Gly Asp 335 Trp Ala Trp Val Leu 160 Ala Ala Arg Leu Val 240 Asp Trp Leu Ala Arg 320 Val Ala Ala Leu Gly Ala Glu Pro Arg Tyr Val His Gin (212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1003) <223> RXS02228 aoagaagcgt caactgctca acttctcgac agcgacgaca gttgctcgct ggacttttta acttaaggga gatctagatc cacacggogt gggacgctac gtg gta aca ccg atc 11. Val Val Thr Pro Ile gca gtg gtt gga ccc act goa tot gga aaa tca got ttg gga Ala Val Val Gly Pro Thr Ala Ser Gly Lys Ser Ala Leu Giy att gct Ile Ala cta gcc cac Leu Ala His ctg tac aaa Leu Tyr Lys aag Lys ott gao ggt gaa Leu Asp Gly Giu gtc aat gtg gat Val Asn Val Asp too atg oag Ser Met Gin gto gaa gaa Val Giu Glu ggo atg gao ato Gly Met Asp Ile gg c Gly aoq goa aag ctg Thr Ala Lys Leu ogo gaa Arg Glu ggo att gog oat Gly Ile Ala His oag oto gat gto Gin Leu Asp Val tgg T rp gao gtt aco gaa Asp Val Thr Glu act Thr gog toa gtg gcg Ala Ser Val Ala agg Arg 75 ttt caa. too gao Phe Gin Ser Asp gtt gco gat gtg Val Ala Asp Val qaa Giu gat att atg too Asp Ile Met Ser ggo aaa aco 000 Gly Lys Thr Pro ttg gtt ggo ggo Leu Val Giy Gly too atg Ser Met 100 ttg tao gto Leu Tyr Val ago got gtt Ser Ala Val 120 oaa Gin 105 tot ttg gto gat Ser Leu Val Asp gat Asp 110 tgg oaa tto oca Trp Gin Phe Pro Oct aoo gao Pro Thr Asp 115 ato ggt gtC Ile Gly Val ogo gca ogo ttt Arg Ala Arg Phe goo ogo ttg goa Ala Arg Leu Ala gao Asp 130 gaa goa Glu Ala 135 ota cac got gaa Leu His Ala Giu aot oag ott gao Thr Gin Leu Asp gaa gca goa goo Glu Ala Ala Ala ato gaa ago aat Ile Giu Ser Asn gat Asp 155 000 oga ogo aoo Pro Arg Arg Thr oga goa tta gaa Arg Ala Leu Glu gt 0 Val1 165 att gaa ota aco Ile Giu Leu Thr ggc Gly 170 cag coo tto oaa Gin Pro Phe Gin ago oaa cog coo Ser Gin Pro Pro aaa gao Lys Asp 180 gcg oca cot cqc tgg gga act oga ato att ggc otg aaa aoc aot oca Ala Pro Pro Arg Trp Gly Thr Arg Ile Ile Gly Leu Lys Thr Thr Pro 185 gaa tgg cta aat cca cgc atc gag Glu Trp Leu Asn Pro Arg Ile Glu 200 205 caa ggc ttt gtc goc gaa gtg gaa Gin Gly Phe Val Ala Giu Val Giu 215 220 gct gac tcc acc gcg gga cga gca Ala Asp Ser Thr Ala Gly Arg Ala 230 235 gcc atg qca ggg gag atg acc tgg Ala Met Ala Gly Giu Met Thr Trp 250 acc gga acc aga cgc tat gtc aqy Thr Gly Thr Arg Arg Tyr Val Arg 265 gao cac cgc gtg toc tgg gtc gac Asp His Arg Val Ser Trp Val Asp 280 285 gcc ttg gag att ttg ggt cta caa Ala Leu Glu Ile Leu Gly Leu Gin 295 300 <210> 278 <211> 301 <212> PRT <213> Corynebacterium qiutamicut <400> 278 Val Val Thr Pro Ile Ala Val Vai 1 5 Ala Leu Giy Ile Ala Leu Ala His Val Asp Ser Met Gin Leu Tyr Lys 40 Leu Thr Vai Giu Giu Arg Giu Gly 55 Trp Asp Val Thr Giu Thr Ala Ser Val Ala Asp Val Giu Asp Ile Met Val Gly Giy Ser Met Leu Tyr Val 100 Phe Pro Pro Thr Asp Ser Ala Val 115 120 190 195 cag cgc acc gcc agg atg ttt Gin Arg Thr Ala Arq Met Phe 210 cac ott gtg cay caa gga ctc His Leu Val Gin Gin Gly Leu 225 atc ggc tac tcc caa gta ctg 1ie Gly Tyr Ser Gin Val Leu 240 gaa gac gcc ttc gaa cgc acg Giu Asp Ala Phe Giu Arg Thr 255 260 090 caa cgc ago tgg ttc aao Arq Gin Arg Ser Trp Phe Asn 270 275 gcc tct. qgc gat ccc acc gca Ala Ser Gly Asp Pro Thr Ala 290 tagcgaqgqt gaatt.tqacc atc gaa Gi u atc Ile gca Al a 245 gtc Val1 aga Arg ca a Gin 1026 Ala Gly Ile His Phe Lys Val1 Phe Ser Giu Gly Gin Gin Thr Asp Giu 125 Gi y ValI Thr Le u Ser Pro Asp 110 Ala Lys Val1 Ala Asp Asp Ile T rp Arg Ala Asp Ile Giy Val Glu Ala Leu His Ala Giu Leu Thr Gln Leu 130 135 140 Pro Glu Ala 145 Arg Ala Leu Gin Pro Pro Leu Lys Thr 195 Ala Arg Met 210 Gin Gin Gly 225 Ser Gin Vai Phe Glu Arg Ser Trp Phe 275 Asp Pro Thr 290 <210> 279 <211> 954 <212> DNA Val1 150 Ile Al a Giu Gin Al a 230 Al a Th r Asp Ala Ile Giu Pro Trp, Gly 215 Asp Met Gly His Leu 295 Giu Leu Pro Leu 200 Phe Ser Al a Thr Arg 280 Gi u Ser Thr Arg 185 As n Val1 Thr Gly Arg 265 Val1 Ile As n Gly 170 Trp Pro Al a Al a Glu 250 Arg Ser Leu Asp 155 Gin Gly Arg Glu Gi y 235 Met T yr T rp Gly Pro Pro Thr Ile Val1 220 Arg Thr Val1 Val1 Le u 300 Arg Phe Arq Glu 205 Giu Ala Trp Arg Asp 285 Gin Thr Al a 175 Ile Arg Leu Gly Asp 255 Gin Ser Val1 160 Ser Gly Thr Val Tyr 240 Al a Arg Gl y <213> Corynebacterium glutamioum <220> <221> GDS <222> (931) <223> RXCO1971 <400> 279 aggtcttgtt tatttcggct actgattcag tagctgcgct cagttcagta tctttgagcc acggctagaa tgtgaatcct cot cqo ccc att ccg gtt cot gcc Pro Arg Pro Ile Pro Val Pro Ala gog cat aca cat ttg gca tog tgt Ala His Thr His Leu Ala Ser Cys gaa agg gcc aag gag gog ggo gtc Glu Arg Ala Lys Giu Ala Gly Val caa ttt ato Gin Phe Ile 15 gga gga gat Gly Gly Asp 30 gaa aag ott Giu Lys Leu cogataggat tcttagtttt atg tot aag aag aag Met Ser Lys Lys Lys 1 cot ggt oto att gat Pro Gly Leu Ile Asp ott gca ggg ttg gtg Leu Ala Gly Leu Val tgt acc gtc ggt gat Cys Thr Val Gly Asp 115 163 211 259 ggt ttg Gly Leu gct gag gcc gag Ala Glu Ala Glu gcg ctg gag gcc Ala Leu Glu Ala g cg Al a caa cag ttt ggc Gin Gin Phe Gly aat Asn gtg ttt gct gcg Val Phe Ala Ala gcg att cat ccg Ala Ile His Pro aag gct gat cag Lys Ala Asp Gin gat ggg gct gcg Asp Gly Ala Ala cgt Arg gcg cgg ctg acg Ala Arg Leu Thr cag Gin 95 atg gcg gcg gat Met Ala Ala Asp ccg aat Pro Asn 100 tgt gtg gcc Cys Val Ala gat cca gag Asp Pro Glu 120 att Ile 105 ggt gag act ggt Gly Glu Thr Gly gat tcg tat tg Asp Ser Tyr Trp atc aag cac Ile Lys His 115 gcg ctg cgc Ala Leu Arg gac acg gcg gcg Asp Thr Ala Ala gat gtg caa gag Asp Val Gin Glu gag Glu 130 tgq cat Trp His 135 att gat ttg gca Ile Asp Leu Ala agt gcg gat aag Ser Ala Asp Lys ttg atg att cac Leu Met Ile His aat Asn 150 cyt gag gcg gat Arg Glu Ala Asp gct Al a 155 gat ttg atg cga Asp Leu Met Arg gtg Val1 160 ttg gcg gat gct Leu Ala Asp Ala cca Pro 165 cct cca aaa gat Pro Pro Lys Asp att ctg cat tgt Ile Leu His Cys tct tcg ccg ttg Ser Ser Pro Leu gac gtg Asp Val 180 qcg aag gaa Ala Lys Glu gtg acg ttt Val Thr Phe 200 gcg Al a 185 ttg gat cgt gga Leu Asp Arg Gly gtg ttg agt ttt Val Leu Ser Phe gcg ggc aat Ala Gly Asn 195 cgt att gcg Arg Ile Ala aag cgt aat gag Lys Arg Asn Glu ttg cgg gag gct Leu Arg Glu Ala gct Ala 210 ccg att Pro Ile 215 tcc cag att ttg Ser Gin Ile Leu gaa acc gat gcg Giu Thr Asp Ala tat atg acg ccg Tyr Met Thr Pro ccg ttt cqg gg Pro Phe Arg Gly agt Ser 235 agg aat gag ccg Arg Asn Giu Pro tcg Ser 240 ttg att ggt cat Leu Ile Giy His acg Thr 245 gcg cta tgc att Ala Leu Cys Ile gag gtt cgg ggg Glu Val Arg Gly gct gtg gag gat Ala Val Glu Asp gtt gcg Val Ala 260 gcg gct -ttg Ala Ala Leu aat As n 265 gag aat ttt gat Giu Asn The Asp gtt tat ggg gtc Vai Tyr Gly Val aca aat cta Thr Asn Leu 275 taacgtgagg tagctcacag tca <210> 280 <211> 277 <212> PRT <213> Corynebacterium glutamicum <400> 280 Met Ser Lys Lys 1 Pro Leu Cys Al a Lys Al a Tyr Glu Pro 145 Leu Se r Ser Ala Pro 225 Le u Val1 Gly Gly Leu Ala Gly Thr Val Gin Gln Ala Asp Ala Asp Trp Ile 115 Glu Ala 130 Leu Met Ala Asp Pro Leu Phe Ala 195 Ala Arq 210 Tyr Met Ile Gly Glu -Asp Vai Thr 275 Lys 5 Asp Val Asp Gly Leu Asn His Arg His Pro 165 Val Asn Ala Pro Thr 245 Ala Leu Pro Arg Pro Ile Pro Val Pro Ala Gin Phe Ile Ala Giu Gly Asn 70 Asp Cys Asp Trp As n 150 Pro Al a Vai Pro Glu 230 Ala Al a His Arg Leu 55 Val1 Gly Val1 Pro His 135 Arg Pro Lys Thr Ile 215 Pro Leu Ala Thr Ala 40 Ala Phe Ala Al a Glu 120 Ile Glu Lys Glu Phe 200 Ser Phe Cys Leu Ser Gly Le u Ala Arg Thr Ala Ile 140 Asp Leu Ar g Glu Ile 220 Arg Val1 Phe Cys Val1 Ala Ile Leu Gly Leu 125 Ser Leu His Gly Glu 205 Glu Asn Arg Asp Gly Giu Le u His Thr Leu 110 Asp Al a Met Cys Tyr 190 Leu Thr Glu Gly Arg 270 Gly Lys Glu Pro Gin Asp Val1 Asp Arg Phe 175 Val1 Arg Asp Pro Met 255 Val1 Asp Leu Ala Thr Met Ser Gin Lys Val1 160 Se r Leu Giu Al a Ser 240 Al a Tyr' <210> <2 11> <212> 213> <220> <221> <222> <223> 281 1650 DNA Corynebacterium glutamicum CDS (101). (1627) RXC02 697 <400> 281 tttggctcac ctcgatgatg tagacatccc cgatgaggtg cgcgcacaqt tgcgggcact ggctatccgc tcaaccgaac gtcggatgta gtagacgcgt atg aca ctt ttt caa Met Thr Leu Phe Gin cgt tta acc aac Arg Leu Thr Asn gta gtg ctc ggc Val Val Leu Gly cta gca ggt gtt Leu Ala Gly Val ttg ctt Leu Leu 163 Ctg Ctc ggc Leu Leu Gly ctc qat gcg Leu Asp Ala ttc ggt ggc ggt Phe Gly Gly Gly gcc Al a att egg tac cgt Ile Arg Tyr Arg ggc gga gtg Gly Gly Val gcg cag ggt Ala Gln Gly ttg ggg ctt aac Leu Gly Leu Asn ctt gct ttt ggc Leu Ala Phe Gly att tee Ile Ser aat acc gtg ttg Asn Thr Val Leu tgg Trp 60 gtt ggg cag ctg Val Gly Gin Leu ctg Leu ctg att ggc gcg Leu Ile Gly Ala qtt cac ctt qga Val His Leu Gly egg ttg tte aaq Arg Leu Phe Lys aaa gtc qct gat Lys Val Ala Asp gac Asp acc gea gac gct Thr Ala Asp Ala gct Al a gac tta ggt ett Asp Leu Gly Leu gta Val1 95 aag cgc aeg ttg Lys Arg Thr Leu tat gc Tyr Ala 100 atg gtg gtg Met Val Val tat tcc tat Tyr Ser Tyr 120 etc att ttt gcg Leu Ile Phe Ala cca atg atg tcg Pro Met Met Ser cgt gat gtt Arg Asp Val 115 ttc gat ccc Phe Asp Pro ctc atg eag gge Leu Met Gln Gly atg ctg egt gat Met Leu Arg Asp gqC Gly 130 tac act Tyr Thr 135 gag ggc gct gcg Glu Gly Ala Ala aac cct ggc ccc Asn Pro Gly Pro ttg ctt gag qtc Leu Leu Glu Val cat gat tgg egc His Asp Trp Arg aac As n 155 ace acg acg ccg Thr.Thr Thr Pro tat Tyr 160 ggt cca cta cac Gly Pro Leu His tgg att gga gac Trp Ile Gly Asp atq Met 170 atc aec acg qtt Ile Thr Thr Val ggc gat aat gtc Gly Asp Asn Val acc ttg Thr Leu 180 ggc gtc gtc Gly Val Val ggc tgg agc Gly Trp Ser 200 gct Ala 185 tac aag ato ttg Tyr Lys Ile Leu t cg Ser 190 atc att ggc ctt Ile Ile Gly Leu gct gtg aca Ala Val Thr 195 aac cca gca Asn Pro Ala att gtc cgc att Ile Val Arg Ile gca Al a 205 caa cat ttt gga Gin His Phe Gly gcc Al a 210 ~i att gca Ile Ala 215 ttg tgg att ggt Leu Trp Ile Gly qcc aat cct gtg Ala Asn Pro Val atc atc cac atg Ile Ile His Met ggc ggc atg cac Gly Gly Met His aat Asn 235 gaa tcc ctc atg Glu Ser Leu Met gtg Val 240 gga ttg gtc agc Gly Leu Val Ser gtc Val1 245 gqc ttg ttg Cta Gly Leu Leu Leu ctg sag sag cgt Leu Lys Lys Arg ttc Phe 255 gtg gcs ggt gtg Val Ala Gly Val gca ctc Ala Leu 260 att gos gtg Ile Ala Val ttt gtg gtg Phe Val Val 280 gtg tcg otg aa Val Ser Leu Lys 505 gcg gcg stt Thr Ala Ala Ile gca ctt cot Ala Leu Pro 275 tta gcc acc Leu Ala Thr tgg atc ggc atg Trp Ile Gly Met cat His 285 cat ttc gca gga His Phe Ala Gly asa sag Lys Lys 295 ggc ass gac too Gly Lys Asp Ser soc ott sag cas Thr Leu Lys Gin gtc ccc gcg ttc Val Pro Ala Phe ttt Phe 310 goc sot gga got Ala Thr Gly Ala gca Ala 315 ggt gtt got gto Gly Val Ala Val act Thr 320 ggt gtt gtt gto Gly Val Val Val 1027 1075 1123 gog sto sot tgg Ala Ile Thr Trp tot ggc got tog Ser Gly Ala Ser ggc tgg ato sgt Gly Trp Ile Ser gag ato Glu Ile 340 agt ggo sac Ser Gly Asn goc agt gtg Ala Ser Val 360 sag gta ato sac Lys Val Ile Asn cog Pro 350 otg got tto cot Leu Ala Phe Pro tot ttg gtg Ser Leu Val 355 gat tto gao Asp Phe Asp 1171 1219 ato soc atg gtg Ile Thr Met Val gas gtg tto gtt Giu Val Phe Val tao sac Tyr Asn 375 gos gtg gtt sat Ala Val Val Asn gtt Val 380 gtg ogo tos ato Val Arg Ser Ile t cc Ser 385 stg ctg atc stg Met Leu Ile Met ott Leu 390 ggc ggg ttg gtc Gly Gly Leu Val tgt tgg tgg ctg Cys Trp Trp Leu ogo cag sac gas Arg Gin Asn Giu 1267 1315 1363 agg gog gto act Arg Ala Val Thr 505 gos gog got Thr Ala Ala Ala gcc gtg got ttt Ala Val Ala Phe gtg tto Val Phe 420 sat tot gtg 500 ttg cog tgq tao tao gcc ago ttg atc tot ttg oto 41 1411 Asn Ser Val Thr Leu Pro Trp Tyr Tyr Ala Ser Leu Ile Ser Leu Leu 425 430 435 ggc aca ttt aaa cca ccg atg tgg ttg att cgc ttc gca gcg ggt gct 1459 Gly Thr Phe Lys Pro Pro Met Trp Leu Ile Arq Phe Ala Ala Gly Ala 440 445 450 tcg gtq ttt atc gcg ctg atg ttt acc gga agt gga aac cac cag ctg 1507 Ser Val Phe Ile Ala Leu Met Phe Thr Gly Ser Gly Asn His Gin Leu 455 460 465 tac aac atc gtt acg gtg atc atc gca gca att atc'gcg tgg ctt gcc 1555 Tyr Asn Ilie Val Thr Vai Ile Ile Ala Ala Ile Ile Ala Trp Leu Ala 470 475 480 485 acc gtg gtg atc ttt gat gac act gac cct gca aca acg gcc acg gag 1603 Thr Val Val Ile Phe Asp Asp Thr Asp Pro Ala Thr Thr Ala Thr Glu 490 495 500 aaa ccc: tcc ccg cat acc gtt tcc tagttqcata aggtaaaccg cca 1650 Lys Pro Ser Pro His Thr Val Ser 505 <210> 282 <211> 509 <212> PRT <213> Corynebacterium glutamicum <400> 282 Met Thr Leu Phe Gin Arg Leu Thr Asn Pro Val Val Leu Gly Gly Leu 1 5 10 Ala Gly Val Leu Leu Leu Leu Gly Ser Phe Gly Gly Gly Ala Ile Arg 25 Tyr Arg Giy Gly Val Leu Asp Ala Leu Gly Leu Asn Phe Leu Ala Phe 40 Gly His Ala Gin Gly Ile Ser Asn Thr Val Leu Trp Val Gly Gin Leu 55 Leu Leu Ilie Gly Ala Trp Val His Leu Gly Arg Arg Leu Phe Lys Lys 70 75 Lys Vai Ala Asp Asp Thr Ala Asp Ala Ala Asp Leu Gly Leu Val Lys 90 Arg Thr Leu Tyr Ala Met Val Val Pro Leu Ile Phe Ala Ala Pro Met 100 105 110 Met Ser Arg Asp Val Tyr Ser Tyr Leu Met Gin Gly Ala Met Leu Arq 115 120 125 Asp Gly Phe Asp Pro Tyr Thr Glu Gly Ala Ala Val Asn Pro Gly Pro 130 135 140 Met Leu Leu Glu Val Ser His Asp Trp Arg Asn Thr Thr Thr Pro Tyr 145 150 155 160 Gly Pro Leu His Leu Trp Ile Gly Asp Met Ile Thr Thr Val Val Gly Asp Gly GI y Met 225 Giy Ala Ala Gly Gin 305 Gly Trp Phe Val1 Ser 385 Arq Val Leu Phe Gly 465 Ile Asn Le u Ala 210 Ile Leu GI y Ile Phe 290 Val1 Val1 Ile Pro Asp 370 Met Gin Ala Ile Ala 450 As n Ala Thr 180 Val1 Pro His Ser Ala 260 Len Ala Al a Val Gin 340 Leu Phe Ile Gin Val1 420 Leu Gly Gin Leu 165 Leu Thr Al a Met Val1 245 Leu Pro Thr Phe Se r 325 Ile Val1 Asp Met Arg 405 Ph e Len Al a Len Ala 485 Val1 Ser 200 Leu Gly Len Val1 Val1 280 Gly Thr Th r As n Val1 360 Al a Gly Val1 Val1 Phe 440 Phe Ile Val1 Ala 185 Ile Trp Met Len Ala 265 Trp Lys Gly Trp Ser 345 Ile Val1 Len Thr Thr 425 Lys Ile Val1 Ile 170 Tyr Val1 Ile His Al a 250 Val1 Ile Asp Ala Ala 330 Lys Thr Val1 Val Gly 410 Len Pro Ala Thr Phe 490 Lys Arg Gly Asn 235 Len Ser Gly Ser Ala 315 Ser Val1 Met Asn Val1 395 Thr Pro Pro Len Val1 475 Asp Len Ala 205 Ala Ser Lys Lys His 285 Th r Val1 Al a As n Al a 365 Val1 Trp Al a Tyr Trp 445 Phe Ile Thr Ser 190 Gin Asn Len Arg Al a 270 His Len Al a Ser Pro 350 Gin Arg Trp Ala Tyr 430 Len Thr Ala Asp 175 Ile H is Pro Met Ph e 255 Thr Phe Lys Val Trp 335 Len Val1 Ser Len Tyr 415 Ala Ile Gly Al a Pro 495 Ile Phe Val1 Val1 240 Val Al a Ala Gin Thr 320 Gly Al a Phe Ile Phe 400 Al a Ser Arg Ser Ile 480 Ala Thr Thr Ala Thr Giu Lys Pro Ser Pro His Thr Val Ser 500 505 <210> <211> <212> <213> <220> <221> <22 2> <223> 283 1298 DNA Corynebacterium giutamicum C DS (1)..(1275) RXN01946 (400> 283 ato ogc aag Ile Arg Lys 1 tac gaa got Tyr Giu Ala gag gca cgo Glu Ala Arg tac tc Tyr Ser 5 agg ctc qag gaa Arg Leu Giu Giu ttc cag tcg ctc Phe Gin Ser Leu ggc ggc Gly Gly gcc gaa gca gcc Ala Giu Ala Ala ato tgc gac aac Ile Cys Asp Asn ctc ggc ctc Leu Gly Leu ggc ggc cag Gly. Gly Gin atc otc qac cag Ile Leu Asp Gin ctt aaa acc otg Leu Lys Thr Leu too Se r cgc ogc Arg Arg cgc gtc gag ttq Arg Val Giu Leu g cg Al a cag atc ctc ttc Gin Ile Leu Phe goc acc aac ggc Ala Thr Asn Gly too Ser gqc aaa tca aaa. Gly Lys Ser Lys aca ttg ctt oto Thr Leu Leu Leu gao Asp gag ccc acc aac Glu Pro Thr Asn ttg gac gca gao Leu Asp Ala Asp tog Ser atc aco tgg ctc Ile Thr Trp Leu cgt Arg 90 gac ttc ctg gcg Asp Phe Leu Ala aag cac Lys His gaa ggt gga Giu Gly Gly gta tgt aac Val Cys Asn 115 ctg Le u 100 ato atg att tog Ile Met Ile Ser oao His 105 gao gto gaa otg Asp Val Giu Leu Ott ggo gc Leu Gly Ala 110 gaa gcc gat Giu Ala Asp aag att tgg tao Lys Ile Trp Tyr gao gca, gta ogo Asp Ala Val Arg ago Ser 125 gto tao Val Tyr 130 aao atg ggo ttt Asn Met Gly Phe aaa tac gto gat Lys Tyr Vai Asp ogt goa oto gat Arg Ala Leu Asp ga a Giu 145 gca ogo oga ogo Ala Arg Arg Arg ogt Arg 150 gag ogc gca aao Giu Arg Ala Asn gaa aag aag goo Giu Lys Lys Ala 432 480 528 gco cto aag gao Ala Leu Lys Asp got goa ogc ctc Ala Ala Arg Leu gcg aaa gca aco Ala Lys Ala Thr aag got Lys Ala 175 gco gca got aag cag atg ato gco cgt gcg gaa oga atg ato gao aao 7 576 Ala Ala Ala etc gac gaa Leu Asp Glu 195 Lys 180 Gin Met Ile Ala Ala Glu Arg Met Ile Asp Asn 190 atc cgc gta gct Ile Arg Val Ala gac Asp 200 cgc gCC gcc aac Arg Ala Ala Asn gtt tte cca Val Phe Pro gaa cca Glu Pro 210 gca eec tgt gga Ala Pro Cys Gly acc cca ctc aac Thr Pro Leu Asn gcc aag ggc ctg acc Ala Lys Gly Leu Thr 220 gte gac cta gee ate Val Asp Leu Ala Ile atg tac ggc tcc Met Tyr Gly Ser etc Leu 230 gaa gtc ttc gc Glu Val Phe Ala ggc Gly 235 gac aaa ggc tcc Asp Lys Gly Ser cgc Arg 245 gta gte gtc ctc Val Val Val Leu tte aac ggt gca Phe Asn Gly Ala ggt aaa Gly Lys 255 acc ace ctg Thr Thr Leu ggc ggc atc Gly Gly Ile 275 aaa etc etc gee Lys Leu Leu Ala ggt Gl y 265 gtg gaa ego ace Val Glu Arg Thr gac ggc gaa Asp Gly Glu 270 tte gee eag Phe Ala Gin gte ace gga tac Val Thr Gly Tyr gc Gly 280 etc aaa atc ggc Leu Lys Ile Gly tac Tyr 285 gaa eac Glu His 290 gae ace ate gae Asp Thr Ile Asp gac aaa tee gte Asp Lys Ser Val t 99 T rp 300 eaa aac ace ate Gin Asn Thr Ile gaa Glu 305 gcc tgc gcc gac Ala Cys Ala Asp gcc Ala 310 gac eaa caa agc Asp Gin Gin Ser egc age etc etc Arg Ser Leu Leu tee tte atg tte Ser Phe Met Phe gge gaa caa etc Gly Glu Gin Leu caa eca gca gga Gin Pro Ala Gly aca etc Thr Leu 335 tee ggc ggt Ser Gly Gly ego gea aae Arg Ala Asn 355 aaa ace ege etc Lys Thr Arg Leu ctg gee aee ote Leu Ala Thr Leu gtg tee tee Val Ser Ser 350 ett gac eeg Leu Asp Pro 912 960 1008 1056 1104 1152 1200 1248 gtc etg ctt etc Val Leu Leu Leu ga c Asp 360 gag ccc ace aae Giu Pro Thr Asn ate tee Ile Ser 370 ege gaa eag gte Arg Giu Gin Val gac gca ctg cgc Asp Ala Leu Arg ace Thr 380 tac ace ggc gca Tyr Thr Gly Ala gte Val1 385 gte ctg gtt ace Val Leu Val Thr eac His 390 gac ccg ggt gca Asp Pro Gly Ala aaq gee ett gag Lys Ala Leu Glu gaa egc gte ate Glu Arg Val Ile ctt ect gat gge Leu Pro Asp Gly gag gat ctt tgg Glu Asp Leu Trp aat gat Asn Asp 415 eag tae atg gaa ate gtg gaa ttg geg Gin Tyr Met Giu Ile Val Giu Leu Ala taggttetaa ggctgtttat 19 1295 S gct 1298 C) <210> 284 S<211> 425 <212> PRT S <213> Corynebacterium glutamicum <400> 284 Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gin Phe Gin Ser Leu Gly Gly S 1 5 10 0\ 1-- Tyr Glu Ala Asp Ala Glu Ala Ala Gin Ile Cys Asp Asn Leu Gly Leu 25 Glu Ala Arg Ile Leu Asp Gin Gin Leu Lys Thr Leu Ser Gly Gly Gin 40 'q Arg Arg Arg Val Glu Leu Ala Gin Ile Leu Phe Ala Ala Thr Asn Gly 55 Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His 70 75 Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His 90 Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala 100 105 110 Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp 115 120 125 Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp 130 135 140 Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Ala Gly 145 150 155 160 Ala Leu Lys Asp Gin Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala 165 170 175 Ala Ala Ala Lys Gin Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn 180 185 190 Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro 195 200 205 Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr 210 215 220 Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile 225 230 235 240 Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys 245 250 255 Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu 260 265 270 Gly Gly Ile Val Thr Gly Tyr Giy Leu Lys Ile Gly Tyr Phe Ala Gin 275 280 285 Giu His Asp Thr Ile Asp Pro Asp Lys Ser Val. Trp Gin Asn Thr Ile 290 295 300 Giu Ala Cys Ala Asp Ala Asp Gin Gin Ser Leu Arg Ser Leu Leu Gly 305 310 315 320 Ser Phe Met Phe Ser Giy Giu Gin Leu Asp Gin Pro Aia Gly Thr Leu 325 330 335 Ser Giy Gly Giu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser 340 345 350 Arg Ala Asn Val Leu Leu Leu Asp Giu Pro Thr Asn Asn Leu Asp Pro 355 360 365 Ile Ser Arg Giu Gin Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala 370 375 380 Val Val Leu Val Thr His Asp Pro Giy Ala Val Lys Ala Leu Glu Pro 385 390 395 400 Giu Arg Val Ile Val Leu Pro Asp Gly Thr Giu Asp Leu Trp Asn Asp 405 410 415 Gin Tyr Met Giu Ile Val Giu Leu Ala 420 425 <210> 285 <211> 1298 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (1275) <223> FRXA01946 <400> 285 atc cgc aag tac tcc agg ctc gag gaa caa ttc cag tcg ctc ggc gqc 48 Ile Arg Lys Tyr Ser Arg Leu Giu Glu Gin Phe Gin Ser Leu Gly Gly 1 5 10 tac gaa qct gac gcc qaa gca gcc cag atc tgc gac aac ctc ggc ctc 96 Tyr Giu Ala Asp Ala Glu Ala Ala Gin Ile Cys Asp Asn Leu Gly Leu 25 gag gca cgc atc ctc gac cag cag ctt aaa acc ctg tcc ggc ggc cag 144 Giu Ala Arg Ile Leu Asp Gin Gin Leu Lys Thr Leu Ser Gly Gly Gin 40 cgc cgc cgc gtc gag ttg gcg cag atc ctc ttc gcc gcc acc aac ggc 192 Arg Arg Arg Val Giu Leu Ala Gin Ile Leu Phe Ala Ala Thr Asn Gly 55 tcc ggc asa tca aaa acc aca ttg ctt ctc gac gag ccc acc aac cac 240 Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glii Pro Thr Asn His ttg gac gca Leu Asp Ala gaa ggt gga Glu Gly Gly gta tgt aac Val Gys Asn 115 gac tcg Asp Ser ctg atc Leu Ile 100 atc ace tgg etc Ile Thr Trp Leu cgt gac Arg Asp 90 ttc ctg gcg Phe Leu Ala aag cac Lys His 288 atg att tcg Met Ile Ser cac His 105 qac qtc gaa ctg Asp Val Giu Leu ctt ggc gcc Leu Gly Ala 110 gaa gcc gat Glu Ala Asp 336 384 aag att tgg tac Lys-Ile Trp Tyr gac gca gta cgc Asp Ala Val Arg gte tac Val Tyr 130 aac atg ggc ttt Asn Met Gly Phe aaa tac gte gat Lys Tyr Vai Asp cgt gca ctc gat Arq Ala Leu Asp gca cgc cga cgc Ala Arg Arg Arg cg t Arg 150 gag cgc gca aae Giu Arg Ala Asn gaa aag aag gee Glu Lys Lys Ala gga Gi y 160 gcc etc aag gac Ala Leu Lys Asp gct gca cgc etc Ala Ala Arg Leu ggc Gly 170 gcg aaa gca acc Ala Lys Ala Thr aag gct Lys Ala 175 gee gca get Ala Ala Ala ctc gac gaa Leu Asp Gin 195 a ag Lys 180 cag atg ate gc Gin Met Ile Ala geg gaa cga atg Ala Giu Arg Met atc gac aac Ile Asp Asn 190 gtt ttc cca Val Phe Pro atc egc gta get Ile Arq Val Ala ga c Asp 200 cgc gcc gee aae Arg Ala Ala Asn ate Ile 205 gaa cca Gin Pro 210 gca. ccc tgt gga Ala Pro Cys Gly ace cca. etc aac Thr Pro Leu Asn aag ggc etg ace Lys Gly Leu Thr atg tac qqe tee Met Tyr Gly Ser gaa gte ttc gcc Gin Val Phe Ala ggc Gly 235 gtc gac cta gee Val Asp Leu Ala gac aaa ggc tee Asp Lys Gly Ser cg e Arg 245 gta gte gte etc Val Val Val Leu ttc aac ggt gca Phe Asn Gly Ala ggt aaa Gly Lys 255 ace acc ctg Thr Thr Leu ggc qgc ate Gly Gly Ile 275 aaa etc etc gcc Lys Len Leu Ala ggt Gi y 265 ytg gaa cgc ac Val Glu Arg Thr gac ggc gaa Asp Gly Glu 270 tte gee cag Phe Ala Gin 816 864 gte ace gga tac Val Thr Gly Tyr cte aaa ate ggc Len Lys Ile Gly gaa cac Gin His 290 gac acc atc gac Asp Thr Ile Asp gac aaa tee gte Asp Lys Ser Val tgg Trp 300 eaa aae ace ate Gin Asn Thr Ile 912 960 gce tge gee gae Ala Cys Ala Asp gee Al a 310 gae eaa eaa age Asp Gin Gin Ser ege age ete etc Arg Ser Len Leu tcc tto atg ttc toc ggc gaa caa Ser Phe Met Phe Ser Gly Giu Gin 325 tcc ggc ggt gaa aaa acc cgc ctc Ser Gly Gly Giu Lys Thr Arg Leu 340 cgo gca aac gtc ctg ctt ctc gac Arg Ala Asn Val Leu Leu Leu Asp 355 360 atc toc cgc gaa cag gtc ctc gac Ile Ser Arg Giu Gin Val Leu Asp 370 375 gte gtc ctg gtt acc cac gac ccg Val Val Leu Val Thr His Asp Pro 385 390 gaa cgc gto ato gtg ctt cct gat Giu Arg Val Ile Val Leu Pro Asp 405 cag tac atg gaa ato gtg gaa ttg Gin Tyr Met Giu Ile Val Giu Leu 420 gct <210> 286 <211> 425 <212> PRT <213> Corynebacteriun glutamicur (400> 286 Ile Arg Lys Tyr Ser Arg Leu Giu 1 5 Tyr Glu Ala Asp Ala Giu Ala Ala Giu Ala Arg Ile Leu Asp Gin Gin Arg Arg Arg Val Giu Leu Ala Gin Ser Gly Lys Ser Lys Thr Thr Leu 70 Leu Asp Ala Asp Ser Ile Thr Trp Giu Gly Gly Leu Ile Met Ile Ser 100 Val Cys Asn Lys Ile Trp Tyr Leu 115 120 ctc gac caa cca gca gga aca cto Leu Asp Gin Pro Ala Gly Thr Leu 330 335 gca ctg goc acc cto gtg too too Ala Leu Ala Thr Leu Val Ser Ser 345 350 gag ccc acc aac aac Ott gac ccg Giu Pro Thr Asn Asn Leu Asp Pro 365 gca otg cgc acc tao aoc ggc gca Ala Leu Arg Thr Tyr Thr Gly Ala 380 ggt goa gtc sag goo ott gag oca Gly Ala Val Lys Ala Leu Giu Pro 395 400 ggo acc gag gat ott tgg aat gat Gly Thr Giu Asp Leu Trp Asn Asp 410 415 gog taggttotaa ggctgtttat Ala 425 1008 1056 1104 1152 1200 1248 1295 1298 Gin Ile L ys Leu Leu Arg Asp Ala Phe Cys Thr Phe Asp 75 Asp ValI Val1 Leu Le u Gly Thr Thr Ala Leu 110 Glu Gly Le u Gin Gi y His His Ala Asp Val Tyr Asn Met Gly Phe Ser 130 135 Lys Tyr Val Asp Ala Arg Ala Leu Asp 140 Glu 145 Al a Al a Le u Glu Lys 225 Asp Thr Gly Giu Glu 305 Se r Ser Arg Ile Val 385 Glu Gin Al a Le u Al a Asp Pro 210 Met Lys Thr Gly His 290 Al a Phe Gly Al a Ser 370 Val1 Arg Tyr Arg Lys Al a Glu 195 Al a Tyr Gly Le u Ile 275 Asp Cys Met Gly As n 355 Arg Leu Val1 Met Arg Asp Lys 180 Ile Pro Gi y Ser Leu 260 Val1 Thr Al a Phe Gi u 340 Val1 Giu Val1 Ile Glu 420 Arq Gin 165 Gin Arg Cys Ser Arg 245 Lys Thr Ile Asp Ser 325 Lys Le u Gin Thr Val1 405 Ile Ar g 150 Ala Met Val Gly Le u 230 ValI Le u Gly Asp Al a 310 Gly Thr Leu Val His 390 Leu Val1 Glu Al a Ile Al a Lys 215 Giu ValI Leu T yr Pro 295 Asp Glu Arq Leu Leu 375 Asp Pro Giu Ala Leu Arg 185 Arg Pro Phe Leu Gly 265 Leu Lys Gin Leu Ala 345 Giu Al a Gly Gly Al a 425 Asn Gly 170 Ala Ala Leu Ala Gly 250 Val Lys Ser Ser Asp 330 Leu Pro Leu Ala Thr 410 Ala 155 Al a Giu Ala As n Gly 235 Ph e Giu Ile Val1 Le u 315 Gin Al a Thr Arg Val 395 Glu Glu Lys Arg Asn Ala 220 Val As n Arg Gly Trp 300 Arg Pro Thr Asn Thr 380 Lys Asp Lys Ala Met Ile 205 Lys Asp Gly Thr Tyr 285 Gin Se r Ala Leu As n 365 Tyr Al a Leu Al a Lys 175 Asp Phe Leu Ala Cly 255 Giy Al a Thr Leu Th r 335 Se r Asp Gly Giu As n 415 Gi y 160 Ala As n Pro Th r Ile 240 Lys Giu Gin Ile GI y 320 Leu Se r Pro Al a Pro 400 Asp <210> 287 <211> 1812 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1789) <223>' RXN00164 <400> 287 ctgctttgcg ggaggttatg aaatgagtgg ggagacgtcg gqccagcctg ccgcaagtgc ggcgcgaggt ggcccggcag aaaagcatgc gctttccgtt gtg ggt cgt att ccg 115 Val Gly Arg Ile Pro 1 cgg gcg aag tgg Arg Ala Lys Trp t gg Trp ttt tta ggc gcg Phe Leu Gly Ala gtg ttg ctg agt Val Leu Leu Ser gcg ggc Ala Gly gct tat gcg Ala Tyr Ala ctg gtg tcc Leu Val Ser gtg ctq gtg ccg Val Leu Val Pro cag Gin gtg ctq ggg cgg Val Leu Gly Arg att gtg gat Ile Val Asp ctc agt gtg Leu Ser Val gat ggc gcg cag Asp Gly Ala Gin cqt gat ttt gtt Arg Asp Phe Val att ctc Ile Leu att gcg gtg gca Ile Ala Val Ala gcc ggc gcg gtg Ala Gly Ala Val ctc Leu agt gcg tgc qg Ser Ala Cys Gly ttc Phe tat gtg gtg tcg Tyr Val Val Ser c9g Arg 75 att tct gag aag Ile Ser Giu Lys atc gcc aat ttg Ile Ala Asn Leu agg Arg gaa gat atg gtq Giu Asp Met Val acc qcg ctt ggg Thr Ala Leu Gly ccc acg cac cag Pro Thr His Gin qtg gaa Val Giu 100 gat gcg ggc Asp Ala Gly ggc gat ttg gtg Gly Asp Leu Val ag c Ser 110 cgc tcc acc gat Arg Ser Thr Asp gat qtc tcc Asp Val Ser 115 agt tcc tca Ser Ser Ser gag cta tcc gca Giu Leu Ser Ala 120 gcg gtg aca Ala Val Thr acc gtc ccg att Thr Val Pro Ile ctg ttt Leu Phe 135 acc att gcc gcg Thr Ile Ala Ala acg atc Thr le 140 att gcg ctq Ile Ala Leu ttt Phe 145 tct ttg gac tgg Ser Leu Asp Trp caa Gin 150 ttt gtq ctc att Phe Val Leu Ile gtc gtg gtg gcg Val Val Val Ala gtg tac tac ttc Val Tyr Tyr Phe tcc aag cac tat Ser Lys His Tyr agc aag gcg ccg Ser Lys Ala Pro ga t Asp 175 cgg tat gcg gca Arg Tyr Ala Ala gaa cgc Giu Arg 180 gcg gcg atg gcg gag cgt gcg cqa aag gta ctt gag qct att cgc ggg Ala Ala Met Ala Giu Arg Ala Arg Lys Val Leu Giu Ala Ile Arg Gly cgt gca act Arg Ala Thr 200 gtg cgg gcg tat Vai Arg Ala Tyr atg gaa gat gcc Met Giu Asp Ala atg Met 210 cat aat cag His Asn Gin att gat Ile Asp 215 cag gcg teg tgg Gin Aia Ser Trp t ct S er 220 gtg gtg gtc aag Vai Vai Vai Lys ggt Gly 225 att cgt gcg cgc Ile Arg Ala Arg acc Thr 230 acc atg ttg att Thr Met Lea Ile aac atg tqq atg Asn Met Trp Met ttt gcg gaa tte Phe Aia Giu Phe ct C Le u 245 atg etc gcg gte Met Leu Ala Val geg Ala 250 ttg gtg atc ggc Leu Val Ile Gly tac Tyr 255 aag ctg gte att Lys Leu Val Ile gat aat Asp Asn 260 gcg ctg acg Ala Leu Thr ctg cgt ggc Leu Arg Gly 280 gge geg gtt acc Gly Ala Val Thr gg t Gi y 270 gec gtg ctg atg Ala Val Leu Met att att egt Ile Ile Arg 275 aec att caa Thr Ile Gin ecg atg aat atq Pro Met Asn Met ttc Ph e 285 atg ege gtg etc Met Arg VIal Leu gac Asp 290 tec gge Ser Gly 295 tat geg tcg etg Tyr Aia Ser Leu cgc atc gtg gga Arg Ile Val Gly gtt gcg gat ceg Val Ala Asp Pro att cet gtg ec Ilie Pro Val Pro ga c Asp 315 age qgt gtg aaa Ser Gly Val Lys gea Al a 320 cet cag ggc aaa Pro Gin Giy Lys gt g Val1 325 1027 1.075 1123 gaa ttg ege aac Giu Leu Arg Asn age ttt age tat Ser Phe Ser Tyr gat tee tgq geg Asp Ser Trp Ala gtg aaa Val Lys 340 gac ate gac Asp Ile Asp gca tet ggc Ala Ser Giy 360 ate Ile 345 aeg ate aat tee Thr Ile Asn Ser gaa act gte geg Glu Thr Val Ala etc gtg gge Leu Val Giy 355 geg ggc ttg Ala Gly Leu 1171 1219 gca ggt aag aeg Ala Gly Lys Thr acg Thr 365 gte gee gee ttg Val Ala Ala Leu egg gtg Arg Val 375 eca gat caa ggg Pro Asp Gin Gly gtg ctt gte gae Val Leu Val Asp gac Asp 385 tte eec gte tet Phe Pro Val Ser cac His 390 etc tet gac ege Leu Ser Asp Arg egt ate gee ege Arg Ile Ala Arg gee atg gte age Ala Met Val Ser 1267 1315 1363 gag gtt cat gtt Giu Val His Val ttc Phe 410 tee gge aeg ctg Ser Giy Thr Leu eag gat etc ace Gin Asp Leu Thr ttg get Leu Ala 420 aaa eca gat Lys Pro Asp tce gat gag gaa Ser Asp Glu Giu geg cat get ctt Ala His Ala Leu ggg caa gtt Gly Gin Val 435 1411 aat gcc ctt gac tgg ttg gag agt ctt cca gaa gga ctg gac acq gtc: 1459 Asn Ala Leu Asp Trp, Leu Glu Ser Leu Pro Glu Gly Leu Asp Thr Val 440 445 450 gtt ggt gcg cga gqa atc cag cta gaa cca gtg gtg gct cag cag ttg 1507 Val Gly Ala Arg Gly Ile Gln Leu Giu Pro Val Val Ala Gln Gin Leu 455 460 465 gcg ttg gcc cgg gtg ttg ttg ctc aat ccg gcg atc gtc atc atg gat 1555 Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala Ile Val Ile Met Asp 470 475 480 485 gaa gcc acg gca gaa gca gga tcg gcg ggt gcc agc gca ctg gaa gag 1603 Giu Ala Thr Ala Giu Ala Gly Ser Ala Gly Ala Ser Ala Leu Giu Giu 490 495 500 gct gca gat gca gtg agc aag aac cgt tcc gca ttg gtg gtg gcg cac 1651 Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala Leu Val Val Ala His 505 510 515 cgg ttg gat cag gca tcg cgg gct gat cag att ctg gtg atg gat aag 1699 Arg Leu Asp Gin Ala Ser Arg Ala Asp Gin Ile Leu Val Met Asp Lys 520 525 530 gqg gag gtt gtg gaa tcc ggt act cac cag gag tta ttg gat cac ggg 1747 Gly Giu Val Vai Glu Ser Gly Thr His Gin Giu Leu Leu Asp His Gly 535 540 545 ggt att tat cag cgt ctg tgg act gcg tgg agt gtc gga aga 1789 Gly Ile Tyr Gin Arg Leu Trp Thr Ala Trp Ser Val Giy Arg 550 555 560 tagttgactg ttcaatgcgt tga 1812 <210> 288 <211> 563 <212> PRT <213>' Corynebacterium giutamicun <400> 288 Val Gly Arg Ile Pro Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val 1 5 10 Leu Leu Ser Ala Gly Ala Tyr Ala Ser Val Leu Val Pro Gin Val Leu 25 Gly Arg Ile Val Asp Leu Val Ser Asp Gly Ala Gin Met Arg Asp Phe 40 Vai Giu Leu Ser Val Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val 55 Leu Ser Ala Cys Gly Phe Tyr Val Val Ser Arg Ile Ser Giu Lys Ile 70 75 Ile Ala Asn Leu Arg Giu Asp Met Val Gly Thr Ala Leu Gly Leu Pro 90 Thr His Gin Val Giu Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser Thr Ile Phe 145 Val Tyr Glu Ala Gly 225 Phe Leu Leu Leu Val 305 Pro Ser Val Leu Asp 385 Ala Asp Leu 130 Ser Tyr Ala Ala Met 210 Ile Ala Val Met Asp 290 Val Gin Trp Ala Leu 370 Phe Met Asp 115 Ser Leu Tyr Ala Ile 195 His Arg Glu Ile Ile 275 Thr Ala Gly Ala Leu 355 Ala Pro Val 100 Val Ser Asp Phe Glu 180 Arg Asn Ala Phe Asp 260 Ile Ile Asp Lys Val 340 Val Gly Val Ser Ser Ser Trp Ala 165 Arg Gly Gin Arg Leu 245 Asn Arg Gin Pro Val 325 Lys Gly Leu Ser Gin 405 Glu Leu Gin 150 Ser Ala Arg Ile Thr 230 Met Ala Leu Ser Pro 310 Glu Asp Ala Arg His 390 Glu Leu Phe 135 Phe Lys Ala Ala Asp 215 Thr Leu Leu Arg Gly 295 Ile Leu Ile Ser Val 375 Leu Val Ser 120 Thr Val His Met Thr 200 Gin Met Ala Thr Gly 280 Tyr Pro Arg Asp Gly 360 Pro Ser His 105 Ala Ile Leu Tyr Ala 185 Val Ala Leu Val Ile 265 Pro Ala Val Asn Ile 345 Ala Asp Asp Val Ala Ala Ile Leu 170 Glu Arg Ser Ile Ala 250 Gly Met Ser Pro Val 330 Thr Gly Gin Arg Phe 410 Val Ala Pro 155 Ser Arg Ala Trp Leu 235 Leu Ala Asn Leu Asp 315 Ser Ile Lys Gly Glu 395 Ser Thr Thr 140 Val Lys Ala Tyr Ser 220 Asn Val Val Met Ala 300 Ser Phe Asn Thr Gin 380 Arg Gly Glu 125 Ile Val Ala Arg Ser 205 Val Met Ile Thr Phe 285 Arg Gly Ser Ser Thr 365 Val Ile Thr 110 Thr Ile Val Pro Lys 190 Met Val Trp Gly Gly 270 Met Ile Val Tyr Gly 350 Val Leu Ala Leu Leu 430 Val Ala Ala Asp 175 Val Glu Val Met Tyr 255 Ala Arg Val Lys Gly 335 Glu Ala Val Arg Arg 415 Pro Leu Pro 160 Arg Leu Asp Lys Leu 240 Lys Val Val Gly Ala 320 Asp Thr Ala Asp Leu 400 Gln Asp Leu Thr Leu Ala Lys Pro Asp Ala Ser Asp Glu Glu Ala His Al a Gly ValI 465 Ile Ser Le u Leu Le u 545 Val Gly 435 As p Gln Ilie Le u Val1 515 Met Asp Arg Val1 Val1 Leu Asp 485 Glu His Lys Gly As n Val1 Al a 470 Giu Ala Arg Gly Gly 550 Ala Gly 455 Leu Ala Ala Leu Glu 535 Ile Leu 440 Ala Al a Thr Asp Asp 520 Val1 Tyr Trp Gly Val Glu 490 ValI Ala Glu Arg Leu Ile Leu 475 Al a Ser Ser Ser Le u 555 Giu Gin 460 Leu Gly Lys Arg Gly 540 T rp Ser 445 Leu Leu Ser As n Al a 525 Thr Thr Le u Glu Asn Ala Arg 510 Asp His Ala Pro Pro Pro Gly 495 Ser Gin Gin Trp Giu Val1 Ala 480 Ala Al a Ile Glu Se r 560 <210> 289 <211> 1812 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1789) <223> FRXA00164 <400> 289 ctgctttgcg ggaggttatg aaatgagtgg ggagacgtcg ggccagcctg ccgcaagtqc ggcqcgaggt ggcccggcag Cgg Arg gct Ala ctg Leu att ile aag Lys gcg Al a tcc Ser att Ile tgg Trp gtg Val1 Gly gtg Val tta Leu gtg Val cag Gin att Ile gtg Val1 ctg Le u ttt Phe gtg Val1 aaaagcatgc gctttccgtt gtg ggt cgt att ccg Val Gly Arg Ile Pro 1 ttg ctg agt gcg ggc Leu Leu Ser Ala Gly ggg cgg att gtg gat Gly Arg Ile Val Asp gtt gag ctc agt gtg Val Glu Leu Ser Val ctc agt gcg tqc ggg Leu Ser Ala Cys Gly 115 163 211 259 307 ttc tat gtg gtg tog egg att tct gag aag att atc gcc Tyr Val Val Ser Ile Ser Glu Lys Ile Ala aat ttg agg 355 Asn Leu Arg gaa gat atg gtg Glu Asp Met Val ggc Gly ace gcg ctt ggg ttg ccc acg cac cag Thr Ala Leu Gly Leu Pro Thr His Gin 95 gtg gaa Val Glu 100 gat geg gge Asp Ala Gly gag eta tee Glu Leu Ser 120 ggc gat ttq gtg Gly Asp Leu Val cgo tee ace gat Arg Ser Thr Asp gat gte tee Asp Val Ser 115 agt tec tea Ser Ser Ser gca gcg gtq aca Ala Ala Val Thr gag Glu 125 ace gte ccg att Thr Val Pro Ile etg ttt Leu Phe 135 acc att gee gcg Thr Ile Ala Ala ate att geg etg Ile Ile Ala Leu tet ttg gae tgg Ser Leu Asp Trp eaa Gin 150 ttt gtg etc att Phe Val Leu Ile cct Pro 155 gte gtg gtg gcg Val Val Val Ala cog Pro 160 gtg tao tae tte Val Tyr Tyr Phe tee aag eac tat Ser Lys His Tyr age aag gog ccg Ser Lys Ala Pro cgg tat geg gca Arg Tyr Ala Ala gaa cgo Glu Arg 180 gcg geg atg Ala Ala Met egt gca act Arg Ala Thr 200 gag egt geg cga Glu Arg Ala Arg aag Lys 190 gta ett gag get Val Leu Glu Ala att cgc ggg Ile Arg Gly 195 eat aat eag His Asn Gin gtg egg gcg tat Val Arg Ala Tyr atg gaa gat gee Met Glu Asp Ala att gat Ile Asp 215 eag geg tog tgg Gin Ala Ser Trp tct Ser 220 gtggtg gte aag Val Val Val Lys ggt Gly 225 att egt geg cgo Ile Arg Ala Arg ace Thr 230 ace atg ttg att Thr Met Leu Ile ttg Leu 235 aae atg tgg atg Asn Met Trp Met ttt geg gaa tte Phe Ala Glu Phe 787 835 883 atg etc geg gte Met Leu Ala Val ttg gtg ate ggo Leu Val Ile Gly aag etg gte att Lys Leu Val Ile gat aat Asp Asn 260 gcg ctg acg Ala Leu Thr ctg egt gge Leu Arg Gly 280 ate Ile 265 gge geg gtt ace Gly Ala Val Thr ggt Gly 270 gee gtg etg atg Ala Val Leu Met att att ogt Ile Ile Arg 275 ace att eaa Thr Ile Gin ccg atg aat atg Pro Met Asn Met atg ege gtg etc Met Arg Val Leu tee ggo Ser Gly 295 tat geg tcg Tyr Ala Ser ctg gcg Leu Ala 300 cgo ate gtg gga Arg Ile Val Gly gtt Val 305 gtt geg gat ccg Val Ala Asp Pro 1027 att cot gtg ccc Ile Pro Val. Pro age ggt gtg aaa Ser Gly Vai Lys gca Ala 320 cct cag ggc aaa Pro Gin Gly Lys gt g Val1 325 1075 1123 gaa ttg cgc aac Giu Leu Arg Asn gtc Val 330 age ttt agc tat Ser Phe Ser Tyr ggc Gly 335 gat tcc tgg gcg Asp Ser Trp Ala gtg aaa Val Lys 340 gac ate gac C1Asp Ile Asp gca tot ggc Ala Ser Gly 360 acg atc aat tcc Thr Ile Asn Ser gaa act gtc gcg Giu Thr Val Ala ctc gtg ggc Leu Vai Gly 355 gcg ggo ttg Ala Gly Leu 1171 1219 gca ggt aag acg Ala Gly Lys Thr acg Thr 365 gte gcc gec ttg Val Ala Ala Leu cgg gtg Arg Val 375 cca gat caa ggg Pro Asp Gin Gly gtg ctt gtc gao Val Leu Val Asp ttc ccc gtc tct Phe Pro Val Ser ctc tct gac cgc Leu Ser Asp Arg gag Giu 395 cgt atc gcc cgc Arg Ile Ala Arg ttg Leu 400 qec atg gtc agc Ala Met Val Ser cag Gin 405 1267 1315 1363 gag gtt cat gtt Glu Val His Val tec ggc acg etg Ser Gly Thr Leu cag gat etc ace Gin Asp Leu Thr ttg get Leu Ala 420 aaa cca gat Lys Pro Asp aat gcc ctt Asn Ala Leu 440 tcc: gat gag gaa Ser Asp Glu Glu gcg cat get ott Ala His Ala Leu ggg caa gtt Gly Gin Val 435 gao aeg gtc Asp Thr Val 1411 1459 gac tgg ttg gag Asp Trp Leu Giu agt Se r 445 Ott cca gaa gga Leu Pro Giu Gly gtt ggt Val Gly 455 gcg cga gga atc Ala Arg Gly Ile eta gaa cca gtg Leu Glu Pro Val get cag eag ttg Ala Gin Gin Leu gcg Ala 470 ttg gee egg gtg Leu Ala Arg Val ttg Leu 475 ttg etc aat cog Leu Leu Asn Pro go g Al a 480 ate gte ate atg Ile Val Ile Met ga t Asp 485 1507 1555 1603 gaa gee aeg gca Giu Ala Thr Ala gea gga tog geg Ala Gly Ser Ala ggt Gly 495 gee age gca otg Ala Ser Ala Leu gaa gag Glu Glu 500 get gca gat Ala Ala Asp egg ttg gat Arg Leu Asp 520 gtg age aag aae Val Ser Lys Asn tee gea ttg gtg Ser Ala Leu Val gtg geg cac Val Ala His 515 atg gat aag Met Asp Lys 1651 1699 cag gca tog egg Gin Ala Ser Arg get Ala 525 gat cag att etg Asp Gin Ile Leu gtg Val1 530 ggg gag Gly Giu 535 gtt gtg gaa tee Val Val Giu Ser act cac cag gag Thr His Gin Glu ttg gat eae ggg Leu Asp His Gly 1747 ggt att tat cag egt etg tgg act gog tgg agt gte gga aga 18 1789 Gly Ile Tyr Gin Arg Leu Trp Thr Ala Trp Ser Val Gly Arg 550 555 560 tagttgactg ttcaatgcgt tga <210> 290 <211> 563 <212>~ PRT <213> Corynebacterium glutamicum 1812 <400> 290 Val1 Leu Gly Val1 Le u Ile Thr Thr Ile Phe 145 Val1 Tyr Giu Al a Gly 225 Phe Gly Leu Arg Giu Ser Ala His As p Leu 130 Ser Tyr Al a Ala Met 210 Ile Ala Pro Gly Asp Val1 Gly Arg Glu Ser Ser Trp Al a 165 Arg Gly Gin Arg Le u Arg Ala Ala Tyr Leu Vai Ile Leu 55 Phe Tyr 70 Giu Asp Asp Ala Glu Leu Leu Phe 135 Gin Phe 150 Ser Lys Ala Ala Arg Ala Ile Asp 215 Thr TIhr 230 Met Leu Lys Ala Ser Ile Val1 Met Gi y Se r 120 Thr Val1 His Met Thr 200 Gin Met Al a Trp Ser Asp Ala Val1 Val1 Ser 105 Al a Ile Leu Tyr Al a 185 Val1 Al a Le u Val1 Trp 10 Val1 Gly Val1 Se r Gly 90 Gly Al a Al a Ile Leu 170 Giu Arg Ser Ile Ala Leu Val1 Gin Ile Ile Al a Le u Thr Thr 140 Val1 Lys Al a Tyr Ser 220 Asn Val1 Val1 Gly Pro Met Ala Ser Leu Val Glu 125 Ile Val Al a Arg Ser 205 Val1 Met Ile Thr Ala Gin Arg Gi y Giu Gly Ser 110 Thr Ile ValI Pro Lys 190 Met Val1 Trp Gi y Gly Le u Val1 Asp Ala Lys Leu Arg Val Ala Al a Asp 175 Val1 Giu Val Met Tyr 255 Ala Val1 Leu Phe Val1 Ile Pro Ser Pro Leu Pro 160 Arg Leu Asp Lys Leu 240 Lys Val1 245 250 Leu Val Ile Asp Asn Ala Leu Thr Ile Gly Leu Leu Val1 305 Pro Ser Val1 Leu Asp 385 Al a Asp Ala Gly Val1 465 Ile Ser Leu Leu Leu 545 Val1 Met Asp 290 Val1 Gln 'Prp Ala Leu 3-70 Phe Met Leu Leu Leu 450 Al a Val1 Ala Val1 Val1 530 Leu Gly Ile 275 Thr Al a Gly Al a Le u 355 Ala Pro Val1 Thr Gly 435 Asp Gin Ile Leu Val1 515 Met Asp Ar g 260 Ile Ile Asp Lys ValI 340 Val1 Gi y Val1 Ser Leu 420 Gin Thr Gin Met Giu 500 Al a Asp Arg Gin Pro Val1 325 Lys Gly Le u Ser Gin 405 Ala Val1 Val1 Leu Asp 485 Glu His Lys Leu Ser Pro 310 Glu Asp Ala Arg His 390 Glu Lys As n Val1 Ala 470 Glu Ala Arg Gi y Arg Gly 295 Ile Leu Ile Ser Val 375 Leu Val Pro Ala Gly 455 Leu Ala Ala Leu Glu 535 G l-y 280 T yr Pro Arg Asp Gi y 360 Pro Ser His Asp Leu 440 Al a Ala Thr Asp Asp 520 Val1 265 Pro Ala Val Asn Ile 345 Ala Asp Asp Val1 Ala 425 Asp Arg Arg Ala Ala 505 Gin Val1 Met Se r Pro Val1 330 Thr Gly Gin Arg Phe 410 Ser T rp Gly Val1 Giu 490 Val1 Al a Glu Met Ala 300 Ser Phe As n Thr Gin 380 Arg Gly Glu Glu Gin 460 Le u Gly Lys Arg Gly 540 Phe 285 Arg Gly Ser Ser Thr 365 Vali I le Thr Glu Se r 445 Leu Leu Ser As n Ala 525 Thr 270 Met Ile Val1 Tyr Gly 350 Val1 Le u Al a La u Leu 430 Leu Glu As n Al a Arg 510 Asp His Arg Val Lys Gly 335 Glu Ala ValI Arg Arg 415 Ala Pro Pro Pro Gly 495 Ser Gin Gin Val1 Gly Ala 320 Asp Thr Al a Asp Leu 400 Gin His Glu Val Al a 480 Al a Al a Ile Glu His Gly Gly Ile Tyr Gin Arq Leu Trp Thr Ala Trp Ser 550 555 560 <210> 291 <211> <212> <213> <220> <221> <222> <223> 1140 DNA Corynebacteriun glutamicum C OS (101)..(1117) RXN00243 <400> 291 cactgcgcca gatttttgat gccgacactg tggcaggtgt ttaacaaagc ageccatgat ggaaatgaag aggaacagaa gcgcgctgag tacgaaaaat gtg acc agc gaa caa 115 Val Thr Ser Giu Gin gct tta gat cct. Ala Leu Asp Pro cac eca ggt cag His Pro Gly Gin ttC Phe cgt ctt tct egg Arg Leu Ser Arg att cag Ile Gin 163 ttg ate aae Leu Ile Asn agg gaa gga Arg Giu Gly gga ace tte cac Gly Thr Phe His aeg gtg gac att Thr Val Asp Ile ect gtg ace Pro Val Thr aaa tee aeg Lys Ser Thr 211 259 ate tta gtt ace Ile Leu Val Thr ggt Gly ggt teg gga tea Gly Ser Giy Ser ctg att Leu Ile gat geg ate aeg Asp Aia Ile Thr gta ttg ctt ceg Vai Leu Leu Pro eaa Gin gga aag etg agg Giy Lys Leu Arg aae tet gee gea Asn Ser Ala Ala eag Gin get aat act eeg Ala Asn Thr Pro aat aag gga eqe Asn Lys Gly Arg ttg gtt ace tat Leu Val Thr Tyr ate Ile egt ggc get tgg Arg Gly Ala Trp egt Arg 95 geg cag gag gat Ala Gin Giu Asp eeg etg Pro Leu 100 eag gat eag Gin Asp Gin etq gtt gqa Leu Val Giy 120 gte tee aeg tae Val Ser Thr Tyr egt cee ege gea Arg Pro Arq Ala ace tat teg Thr Tyr Ser 115 cac ace ttg His Thr Leu 451 499 ttg act tat tee Leu Thr Tyr Ser ggt gaa ge gte Gly Giu Gly Val gag Giu 130 gtg get Val Ala 135 att ttc tat etg Ile Phe Tyr Leu aaa Lys 140 teg gga eac aat Ser Gly His Asn aec tee gat att Thr Ser Asp Ile tet Ser 150 tea tat tat ggt Ser Tyr Tyr Gly ttt eec gtt gat Phe Pro Val Asp caa Gin 160 gac ate aat geg Asp Ile Asn Ala etg Le u 165 547 595 643 etg gat tte etg Leu Asp Phe Leu aaa Lys 170 gag gge ate gat Giu Gly Ile Asp ege eag ate aga Arg Gin Ile Arg get get. Ala Ala 180 tte aag gaa gee ate ttt age gag eag cat tet. gta ttc tee gge agg Phe ttt Phe cac His Cgg Arg 230 qcc Al a ga t Asp aat Asni aaq Lys gaa Gin 310 agg Lys a ga Arg ogo Arg 215 ga t Asp gtg ValI att Ile Ar g aag Lys 295 cg Pro tgg Glu agc Ser 200 gcg Al a tac Tyr gaa Glu aaa Lys cga Arg 280 gog Ala ctg Len agt Ala 185 cgt Arg cag Gin atg Met caa Gin Cgg Arg 265 gag Gin ctg Leu gtt Val1 ooq Ile ttg Len tog Ser ctg Len ttC Phe 250 cag Gin aaa Lys Cog Pro cga Arg cca Phe ggg 01 y gcg Al a gtg Val1 235 caa Gin ato Ile gcg Ala act Thr caa Gin 315 aaa Ser atc: Ile aaa Lys 220 gaa Gin gao Asp cac His oaa Gin gto Val 300 ttt Phe ttg Leu Gin toc Ser 205 gat Asp cog Pro ott Len acc Thr cag Gin 285 ggg Gi y act Thr aga Ar g Gin 190 agt Ser ctt Leu ga t Asp 988 Gin ctg Len 270 too Se r aa t As n gtc Val1 cag Gin His gag Gin oaa Gin a cg Thr ggt Gly 255 gat Asp aaa Lys ogo Ar g gag Gin ato Ile 335 Se r gaa Gin agc Ser tto Phe 240 got Al a oct Pro gat Asp att Ile caa Gin 320 qtg Vali Val1 got Al a t tg Len 225 ago Se r tat Tyr ttg Leu cat His aag Lys 305 acg Thr coo Pro Phe t tg Leu 210 ga t Asp att Ile gag Gin gtg Val1 900 Al a 290 aag Lys cag Gin gog Ala Ser 195 otg Leu gat Asp gc Al a cag Gin cag Gin 275 aat As n gaa Giu cga Arg aaa Lys Gly t tg Leu cta Leu aaa Lys gto Vali 260 ctg Leu gca Ala gag Glu agt Ser Arg ttg Le u ttt Phe act Th r 245 gaa Glu aag Lys ctg Len caa Gin cga Arg 325 739 787 835 883 931 979 1027 1075 1117 Arg Trp Ser Pro Pro Lys 330 tgaaaaccct cgcgcaogac: aac <210> 292 <211> 339 <212> PRT <213> Corynebacterium giutamioun <400> 292 Vai Thr Ser Gin Gin Ala Leu Asp Pro Ile 1 5 10 Len Ser Arg Ile Gin Le Ile Asn Trp Gly 25 Asp Ile Pro Val Thr Arg Gin Gly Ile Leu 40 Ser Giy Lys Ser Thr Leu Ile Asp Ala Ile 55 Gin Giy Lys Leu Arg Phe Asn Ser Aia Ala 1140 His Pro Gly Gin Phe Thr Phe His Gly Thr Vai Thr Giy Giy Ser Thr Aia Vai Leu Len Gin Ala Asn Thr Pro Arg Val1 Gly Pro Arg Asn Gin Arq Val1 Leu 145 Asp Gin Val1 Ala Leu 225 Ser Tyr Leu His Lys 305 Thr Pro Lys Gly Arg Ser Giu Asp Ala Thr 115 Giu His 130 Thr Ser Ilie Asn Ile Arg Phe Ser 195 Leu Leu 210 Asp Asp Ile Ala Giu Gin Val Gin 275 Ala Asn 290 Lys Glu Gin Arg Ala Lys Pro 100 T yr Thr Asp Ala Ala 180 Gly Leu Le u Lys Val1 260 Leu Ala Giu Ser Le u Ser Le u Ilie Leu 165 Al a Ar g Le u Phe Thr 245 Giu Lys Leu Gin Arg 325 Leu Gin Leu Val Ser 150 Leu Phe Phe His Arg 230 Ala Asp As n Lys Giu 310 Arg Vai Thr Tyr Ile Arg Gly Aia Trp Arg Ala Asp Val1 Aia 135 Ser Asp Lys Arg Arg 215 Asp Val Ile Arg Lys 295 Pro Trp Gin Gly 120 Ile Tyr Phe Glu Se r 200 Aila Tyr Glu Lys Arq 280 Aila Le u Se r Ile 105 Leu Phe Tyr Leu Al a 185 Arg Gin Met Gin Arg 265 Glu Leu Val1 Pro 90 Val1 Thr Tyr Gly Lys 170 Ile Leu Ser Leu Phe 250 Gin Lys Pro Arg Pro 330 Ser Tyr be u Val1 155 Giu Ph e Gly Al a ValI 235 Gin Ile Ala Thr Gin 315 Lys T hr Ser Lys 140 Phe Gi y Se r Ile Lys 220 Glu Asp His Gin Val1 300 Phe Le u Tyr Asn 125 Ser Pro Ile Giu Ser 205 Asp Pro Leu Thr Gin 285 Gly Thr Arg Le u 110 Gly Giy Vali Asp Gin 190 Ser Leu Asp Glu be u 270 Ser Asn Val1 Gin Arg Giu His Asp Lys 175 His Glu Gin Thr Gly 255 Asp Lys Arg Giu Ile 335 Pro Gly As n Gin 160 Arg Se r GI u Ser Phe 240 Ala Pro Asp Ile Gin 320 Val1 <210> 293 <211> 1027 <212> DNA <21 3> Corynebacterium giutamicum <220> <221> cDs <222> (1027) <223> FRXA00243 <400> 293 cactgcgcca gatttttgat gccgacactg tggcaggtgt ttaacaaagc agcccatgat ggaaatgaag aggaacagaa gcgcgctgag tacgaaaaat gtg acc agc gaa caa 11! Val Thr Ser Giu Gin gct tta gat cct Ala Leu Asp Pro cac cca ggt caq His Pro Gly Gin cgt ctt tct cgg Arg Leu Ser Arg att cag Ile Gin ttg atc aac Leu Ile Asn agg gaa gga Arg Giu Gly gga acc ttc cac Gly Thr Phe His gga Gly acg gtg gac att Thr Vai Asp Ile cct gtg acc Pro Val Thr aaa tcc acg Lys Ser Thr 211 259 atc tta gtt acc Ile Leu Val Thr ggt tcg gga tca Gly Ser Gly Ser gga Gly ctg att Leu Ilie gat qcg atc acg Asp Ala Ile Thr gcg Ala gta ttg ctt ccg Val Leu Leu Pro gga aag ctg agg Giy Lys Leu Arg ttt aac tct qcc qca Phe Asn Ser Ala Ala ttg gtt acc tat atc Leu Val Thr Tyr Ile gct aat act ccg Ala Asn Thr Pro aat aag gga cgc Asn Lys Gly Arg cg.t ggc gct tgg Arg Gly Ala Trp gcg-cag gag gat Ala Gin Glu Asp ccg ctg Pro Leu 100 cag gat cag Gin Asp Gin ctg gtt gga Leu Vai Gly 120 gtc tcc acg tac Val Ser Thr Tyr Cta Leu 110 cgt ccc cgc gca Arg Pro Arg Ala acc tat tcg Thr Tyr Ser 115 cac acc ttg His Thr Leu 451 499 ttg act tat tcc Leu Thr Tyr Ser aac As n 125 qgt gaa ggc gtc Gly Giu Gly Vai gag Giu 130 gtg gCt Val Ala 135 att ttc tat ctg Ile Phe Tyr Leu tcg gga cac aat Ser Giy His Asn acc tcc gat att Thr Ser Asp Ile tct Ser 150 tca tat tat ggt Ser Tyr Tyr Giy ttt ccc gtt gat Phe Pro Val Asp gac atc aat qcg Asp Ile Asn Ala ctg Leu 165 ctg gat ttc ctg Leu Asp Phe Leu gag ggc atc gat Giu Gly Ile Asp aaa Lys 175 cgc cag atc aga Arg Gin Ile Arg gct gct Ala Ala 180 ttc aag gaa Phe Lys Giu ttt aga agc Phe Arq Ser 200 atc ttt aqc gag Ile Phe Ser Giu cag Gin 190 cat tct gta ttc His Ser Val Phe tcc ggc agcj Ser Gly Arg 195 ctg ttg ttg Leu Leu Leu cgt ttg ggg atc Arg Leu Gly Ile t cc Se r 205 agt gag gaa gct Ser Glu Giu Ala ttg Leu 210 cac cgc gcg cag tcg gcg aaa gat ctt caa agc ttg gat gat cta ttt 787 His Arg Ala Gin Ser Ala Lys Asp Leu Gin Ser Leu Asp Asp Leu Phe 215 220 225 cgg gat tac atg ctg gtg gaa ccg gat acg ttc agc att. gcc aaa act 835 Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe Ser Ile Ala Lys Thr 230 235 240 245 gcc gtg gaa caa ttc caa gac ctt gaa ggt qct tat gag cag gtc gaa 883 Ala Val Glu Gin Phe Gin Asp Leu Glu Gly Ala Tyr Giu Gin Val Giu 250 255 260 gat att. aaa cgg cag atc cac acc ctg gat cct. ttg gtg cag ctq aag 931 Asp Ile Lys Arg Gin Ile His Thr Leu Asp Pro Leu Vai Gin Leu Lys 265 270 275 aat cgg cga gag aaa gcg caa cag tcc aaa gat cat gcc aat gca ctg 979 Asn Arg Arg Giu Lys Ala Gin Gin Ser Lys Asp His Ala Asn Ala Leu 280 285 290 aag aag gcg ctg ccg act gtc qqg aat cgc att aag aag gaa gag caa 1027 Lys Lys Ala Leu Pro Thr Val Gly Asn Arg Ile Lys Lys Giu Giu Gin 295 300 305 <210> 294 <211> 309 (212> PRT <213> Corynebacterium glutamicun <400> 294 Val Thr Ser Glu Gin Ala Leu Asp Pro Ile His Pro Gly Gin Phe Arq 1 5 10 Leu Ser Arq Ile Gin Leu Ile Asn Trp Gly Thr Phe His Gly Thr Vai 25 Asp Ile Pro Val Thr Arg Giu Gly Ile Leu Val Thr Gly Gly Ser Gly 40 Ser Gly Lys Ser Thr Leu Ile Asp Ala Ile Thr Ala Val Leu Leu Pro 55 Gin Gly Lys Leu Arg Phe Asn Ser Ala Ala Gin Ala Asn Thr Pro Arg 70 75 Asn Lys Gly Arg Ser Leu Val Thr Tyr Ile Arg Gly Ala Trp Arg Ala 90 Gin Giu Asp Pro Leu Gin Asp Gin Ile Val Ser Thr Tyr Leu Arg Pro 100 105 110 Arg Ala Thr Tyr Ser Leu Val Gly Leu Thr Tyr Ser Asn Gly Giu Gly 115 120 125 Val Glu His Thr Leu Val Ala Ile Phe Tyr Leu Lys Ser Gly His Asn 130 135 140 Leu Thr Ser Asp Ile Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gin 145 150 155 160 As p Gin Val1 Ala Le u 225 Se r Tyr Leu His Lys 305 Ile Ile Phe Leu 210 Asp Ile Glu Vali Ala 290 Lys As n Arg Ser 195 Leu Asp Ala Gin Gin 275 Asn Glu Al a Al a 180 Gly Le u Leu Lys Val1 260 Le u Al a Glu Leu 165 Al a Arg Leu Ph e Thr 245 Glu Lys Le u Gin Leu Phe Phe His Arg 230 Ala Asp As n Lys Asp Lys Arg Arg 215 Asp Val1 Ile Arg Lys 295 Phe Glu Ser 200 Al a Tyr Gl u Lys Arg 280 Al a Leu Ala 185 Arg Gin Met Gin Arg 265 Giu Leu Lys 170 Ile Leu Ser Leu Phe 250 Gin Lys Pro Glu Phe Gi y Ala Val1 235 Gin Ile Al a Thr Gi y Ser Ile Lys 220 Glu Asp His Gin Val1 300 Ile Glu Ser 205 Asp Pro Leu Thr Gin 285 Gly Asp Gin 190 Ser Le u Asp Giu Leu 270 Ser As n Lys 175 His Glu Gin Thr Gly 255 Asp L ys Arg Arg Se r Glu Se r Phe 240 Al a Pro Asp Ile <210> 295 <211> 2325 <212> DNA (213> Corynebacterium glutarnicum <220> <221> COS <222> (101)..(2302) <223> RXA00259 <400> 295 ggcettatta aeatacggeg gttctagcac acagcgatgq tgetgeatgt geeaagattt agcaeggtac agtgctagaa acc Thr ga t Asp cgt Arg ttt Phe gta Val1 gag Glu tea gat geg gca aaa aac aac Ser Asp Ala Ala Lys Asn Asn 15 tct ggt cga gac ttg cct att Ser Gly Arg Asp Leu Pro Ile 30 egt tct gcg tat tca gee cag Arg Ser Ala Tyr Ser Ala Gin 45 a cg Thr act Thr ctg Leu atgatgtgte ccaccgatat atg age gga ctg ttt Met Ser Gly Leu Phe 1 gta aaa act gat gga Val Lys Thr Asp Gly aag atc tct gag gat Lys Ile Ser Glu Asp gca aat ata ate tge Ala Asn Ile Ile Cys 115 163 211 259 gat gtg Asp Val gca cct tgg gqa Ala Pro Trp Gly gcg Ala agc act gtt ttc Ser Thr Val Phe ctt act ggt cag Leu Thr Giy Gin tgg TrP ggc agt ggt aag Gly Ser Gly Lys cta tcg aac gaa Leu Ser Asn Glu tct ctt gtt aat Ser Leu Val Asn ttg Le u att cgc tcg gaa Ile Arg Ser Glu tct C1 Ser aaa tgg aca atc Lys Trp Thr Ile gat ttc aac ccg Asp Phe Asn Pro tgg qtg Trp Val 100 9CC tct gac Ala Ser Asp gyg acg gta Giy Thr Val 120 caa tct ttg att Gin Ser Leu Ile gag ttt tac cga Giu Phe Tyr Arg gta atc gtt Val Ile Val 115 act gtt ctg Thr Val Leu cct gat gat aag Pro Asp Asp Lys ggc caa aag atc Gly Gin Lys Ile aaa L ys 130 cag aaa Gin Lys 135 acc ttt ago acg Thr Phe Ser Thr att Ile 140 ggg tca att gca Gly Ser Ile Ala ggg gtc gga ggg Gly Val Giy Gly ggt gtc cta gaa, Gly Val Leu Giu gca Ala 155 ott gog ctc tca Leu Ala Leu Ser gga gta. gat gct Gly Val Asp Ala aac gct gta tat Asn Ala Val Tyr aca tgg aaa cag Thr Trp Lys Gin caa. gat tcg tgg Gin Asp Ser Trp cca acg Pro Thr 180 ctg tat aca Leu Tyr Thr ctc att qtc Leu Ile Val 200 gct gcg aac cat Ala Ala Asn His aaa gat ctg aac Lys Asp Leu Asn aag cga att Lys Arg Ile 195 gaa ttg gcg Giu Leu Ala gto gat gat att Vai Asp Asp Ile ga t Asp 205 cgc ctc cat act Arg Leu His Thr gat Asp 210 otg tta Leu Leu 215 atg aaa gta ata Met Lys Val Ile cgc Arq 220 ttg ctt gga cga Leu Leu Gly Arg ttc Phe 225 ccg cag gtg aat Pro Gin Val Asn ctt ttg gtt tat Leu Leu Val Tyr gaa Giu 235 gaa. gaa tca otg Giu Glu Ser Leu tta Le u 240 acg acg ota gcc Thr Thr Leu Ala tog aca got gta Ser Thr Ala Val g gt Gly 250 ggt agc gaa gat Gly Ser Giu Asp gct ttg cgt ttc Ala Leu Arg Phe atg gag Met Giu 260 aaa atc gtg Lys Ile Val ata gag aaa Ile Giu Lys 280 tat cct ttc gat Tyr Pro Phe Asp ccg cct otg aca Pro Pro Leu Thr tca ttt caa Ser Phe Gin 275 cag ggt gtt Gin Gly Val gag ctc agt gca Giu Leu Ser Ala tta Le u 285 ttt qac aag ctt Phe Asp Lys Leu ttc Phe 290 tog cta tcg ggt gat oct gaa gac ttt gca cta gtg aag tcg aga atg 12 1027 Ser Leu Ser Gly Asp Pro As PhAl Le Ly SrAr Mt Asp Phe Ala Leu Lys Ser Arg Met gat gtc tgg gaa Asp Val Trp Glu aag Lys 315 act ctg gtc acg Thr Leu Val Thr aqg ctg ttg cac Arg Leu Leu His 1075 1123 ttt gct gct cta Phe Ala Ala Leu acc aac tgg act Thr Asn Trp Thr cg g Arg 335 ata tat gga tca Ile Tyr Gly Ser ggt gaa Gly Glu 340 gtt aac ggc Val Asn Gly ccg tct gtg Pro Ser Vai 360 gat ctc aca ata Asp Leu Thr Ile gcg acc att cga Ala Thr Ile Arg att gtt ttt Ile Vai Phe 355 ttg ctt caa Leu Leu Gin 1171 1219 tat aaa cgt ctt Tyr Lys Arg Leu cqa gcg aag gaa Arg Ala Lys Glu gta ValI 370 gga ggt Gly Gly 375 cga acg aca ggc: Arg Thr Thr Gly t cg Ser 380 cag aaa ccc ggt Gin Lys Pro Gly gaa aag caa tta Giu Lys Gin Leu gag ggg atg aac Giu Giy Met Asn gag cag atg gat Giu Gin Met Asp ct t Le u 400 tta aaq acc atg Leu Lys Thr Met 1267 1315 1363 ttg ttc ctt ttc Leu Phe Leu Phe cca Pro 410 cgt ctt tcg gat Arg Leu Ser Asp cct agt acg aga Pro Ser Thr Arg atg cat Met His 420 cgt gag agg Arg Giu Arg ttt caa aga Phe Gin Arg 440 atc tcg acg gaa Ile Ser Thr Giu tat ttt gac acg Tyr Phe Asp Thr tac ctc atg Tyr Leu Met 435 gat aag tat Asp Lys Tyr 1411 1459 cct gga cat gtc Pro Gly His Val ata Ile 445 aqt gat gaa cag Ser Asp Giu Gin cta tct Leu Ser 455 aat gcg gac gat Asn Ala Asp Asp atg ggt ttc gtc Met Gly Phe Val ga t Asp 465 tta att aac tcc Leu Ile Asn Ser gat Asp 470 gac aat gac atg Asp Asn Asp Met gt g Val1 475 gca tca gtg atg Ala Ser Val Met aaq ctt cct cta Lys Leu Pro Leu 1507 1555 1603 att gat cga ctt Ile Asp Arg Leu gga gag ggt gtt Gly Giu Gly Val cac atg gca gtt His Met Ala Val gag gtg Giu Val S00 tta ttc acc Leu Phe Thr atg agc ggc Met Ser Gly 520 gct Ala 505 gct aat ggt atg Ala Asn Gly Met cat His 510 gat aaa ggt cgt Asp Lys Gly Arg caa gtg cgt Gin Val Arg 515 tcg att ctt Ser Ile Leu 1651 1699 ata ttc agt gac Ile Phe Ser Asp tat tcc cat gog Tyr Ser His Ala ggt gca ttg cct caa tta cca gtg gaa caa ctc tat gag aaa ttc ttt Gly Ala Leu Pro Gin Leu Pro Val Glu Gin Leu Tyr Glu Lys Phe Phe 1747 540 545 gag aig acg ctt Giu Met Thr Leu gag gct gct ttc Glu Ala Ala Phe tta aac cag gtg Leu Asn Gin Val 999 Gly 565 1795 1843 gaa agg gct aga Giu Arg Ala Arg gcc Al a 570 tqt gqt aat gat Cys Gly Asn Asp gta Vali 575 agt ggc ctt gag Ser Giy Leu Glu ctt ttt Leu Ph~e 580 cqt aaa gtt Arg Lys Val aat cag qac Asn Gin Asp 600 ata aaq acc gaa Ile Lys Thr Glu aga att tta agt Arg Ile Leu Ser gta ttg aag Val Leu Lys 595 ctt ggt att Leu Gly Ile 1891 1939 ccc tca gat tgg Pro Ser Asp Trp ga t Asp 605 tta ggt cca tat Leu Gly Pro Tyr t cg Se r 610 ttg gcg Leu Ala 615 aaa agc tcg aat Lys Ser Ser Asn tct tca gtg ctg Ser Ser Vai Leu aag tct ctg caa agt Lys Ser Leu Gin Ser 625 att gga gtg ctt ttc Ile Gly Val Leu Phe ggt Giy 630 ata gag gaa cat Ile Giu Giu His ca g Gin 635 ttt gat gtg ata Phe Asp Val Ile ga t Asp 640 tta acg act gtg Leu Thr Thr Val tct tcg cga cag Ser Ser Arg Gin cca agc ggt ggt Pro Ser Gly Gly gca tgg Ala Trp 660 1987 2035 2083 2131 2179 ata gat tct Ile Asp Ser cta cgg gct Leu Arq Ala 680 ttt Phe 665 cag cat agt ctg Gin His Ser Leu ttt Phe 670 tca cgg tac gta Ser Arg Tyr Val cct gat tct Pro Asp Ser 675 gqt aag ata Gly Lys Ile ata acc aag tct Ile Thr Lys Ser gta gat gta gaa Val Asp Val Giu cag ttc Gin Phe 695 acg gat ttt agc Thr Asp Phe Ser t gg Trp 700 gaa ggg aag cga Giu Gly Lys Arg aaa Lys 705 gtt gtc gca tat Val Val Ala Tyr 2227 2275 ctg gag act gga Leu Glu Thr Gly aga Arg 715 agt gat ttc act Ser Asp Phe Thr gaa cga tta ggg Giu Arg Leu Giy tac agt atc gca Tyr Ser Ile Ala tct ata gtc gat Ser Ile Val Asp tgatgaggct gaggtcatga 2322 2325 <210> 296 <211> 734 <212> PRT <213> Corynebacterium qiutamicum <400> 296 Met Ser Gly Leu Phe Thr Pro Phe Ser Asp 1 5 10 Ala Ala Lys Asn Asn Thr Val Lys Thr Asp Gly Asp Ser Val. Ser Gly Arg Asp Leu Pro Ile Thr 25 Lys Ala Se r Ile Phe Tyr Ile Gly 145 Gly Asp Leu Thr Phe 225 Thr Leu Leu Leu Val 305 Arg Ile As n Le u Arg As n Arg Lys 130 Gly Val1 Ser Asn Asp 210 Pro Thr Arq Thr Phe 290 Lys Leu Ser Ile Thr Ser Pro Val1 115 Thr Val1 Asp Trp Lys 195 Glu Gin Le u Phe Ser 275 Gin Se r Leu Gi u Ile Gly Glu Trp 100 Ile Val1 Gly Ala Pro 180 Arg Leu Vali Ala Met 260 Phe Gly Arg His Asp Cys Gin Giu Val1 Val1 Le u Gly Ala 165 Thr Ile Ala As n Arg 245 Giu Gin Val1 Met Arg 325 Arg Asp Trp 70 Ser Al a Giy Gin Phe 150 Asn Leu Leu Leu Tyr 230 Ser Lys Ile Ser Phe 310 Phe Phe Val1 55 Gly Leu Ser Thr Lys 135 Gly Ala T yr Ile Leti 215 Leti Thr Ile Giu Leu 295 Asp Al a Giu 40 Ala Ser Ser Asp Val1 120 Thr Val1 ValI Thr Val1 200 Met Leu Ala Val1 Lys 280 Se r Val1 Al a Arg Pro Giy Asn Pro 105 Pro Phe Leu Tyr Arg 185 ValI Lys Val1 Val Gin 265 Glu Gly T rp Leti Ser Trp Lys Giu 90 Gin Asp Ser Glu Lys 170 Ala Asp Val1 Tyr Gly 250 Tyr Leut Asp Giu Leu 330 Ala Gly Thr Lys Ser Asp Thr Ala 155 Thr Al a Asp Ile Glui 235 Gly Pro Ser Pro Lys 315 Thr Tyr Al a Se r Trp Leu Lys Ile 140 Leu Trp Asn Ile Arg 220 Giti Ser Phe Al a Glu 300 Thr Asn Ser Ser Leti Thr Ile Thr 125 Gly Ala Lys His Asp 205 Leu Giti Glu Asp Leut 285 Asp Leu Trp Ala Thr Val1 Ile Giu 110 Gly Ser Leu Gin Phe 190 Arg Leu Ser Asp Val1 270 Phe Phe Val1 Thr Gin Val1 Asn Val1 Gin Ile Ser Giti 175 Lys Leu Gly Leti Asp 255 Pro Asp Al a Thr Arq 335 Tyr Gly Ser Gly Glu Val Asn Gly Val Asp Leu Thr lie Leu Ala Thr 340 345 350 Ile Arg Ile Val Phe Pro Ser Val Tyr Lys Arg Leu Ser Arg Ala Lys 355 360 365 Glu Val Leu Leu Gin Gly Gly Arg Thr Thr Gly Ser Gin Lys Pro Gly 370 375 380 Trp Glu Lys Gin Leu Cys Glu Gly Met Asn Asn Glu Gin Met Asp Leu 385 390 395 400 Leu Lys Thr Met Leu Leu Phe Leu Phe Pro Arg Leu Ser Asp His Pro 405 410 415 Ser Thr Arg Met His Arg Glu Arg Gly Ile Ser Thr Glu Val Tyr Phe 420 425 430 Asp Thr Tyr Leu Met Phe Gin Arg Pro Gly His Val Ile Ser Asp Glu 435 440 445 Gin Leu Asp Lys Tyr Leu Ser Asn Ala Asp Asp Ala Met Gly Phe Val 450 455 460 Asp Leu Ile Asn Ser Asp Asp Asn Asp Met Val Ala Ser Val Met Lys 465 470 475 480 Lys Leu Pro Leu Ala Ile Asp Arg Leu Asp Gly Glu Gly Val Arg His 485 490 495 Met Ala Val Glu Val Leu Phe Thr Ala Ala Asn Gly Met His Asp Lys 500 505 510 Gly Arg Gin Val Arg Met Ser Gly Ile Phe Ser Asp Leu Tyr Ser His 515 520 525 Ala Cys Ser Ile Leu Gly Ala Leu Pro Gin Leu Pro Val Glu Gin Leu 530 535 540 Tyr Glu Lys Phe Phe Ser Glu Met Thr Leu Asn Glu Ala Ala Phe Trp 545 550 555 560 Leu Asn Gin Val Gly Glu Arg Ala Arg Ala Cys Gly Asn Asp Val Ser 565 570 575 Gly Leu Glu Leu Phe Arg Lys Val Asn Ile Lys Thr Glu Ala Arg Ile 580 585 590 Leu Ser Val Leu Lys Asn Gin Asp Pro Ser Asp Trp Asp Leu Gly Pro 595 600 605 Tyr Ser Leu Gly Ile Leu Ala Lys Ser Ser Asn Phe Ser Ser Val Leu 610 615 620 Lys Ser Leu Gin Ser Gly Ile Glu Glu His Gin Phe Asp Val Ile Asp 625 630 635 640 Ile Gly Val Leu Phe Leu Thr Thr Val Tyr Ser Ser Arg Gin Gly Pro 645 650 655 Ser Gly Gly Ala Trp Ile Asp Ser Phe Gin His Ser Leu Phe Ser Arg Tyr Val Pro 675 Glu Len Gly 690 Lys Val Val 705 Gin Arg Leu 660 665 Asp Ser Len Arq Ala Ile 680 Lys Ile Gin Phe Thr Asp 695 Ala Tyr Ala Len Gin Thr 710 Gly Gly Tyr Ser Ile Ala 725 670 Thr Lys Ser Gin Val Asp Val 685 Phe Ser Trp Gin Gly Lys Arg 700 Gly Arg Ser Asp Phe Thr Arg 715 720 Asp Ser Ile Val Asp 730 <210> 297 <211> 789 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(766) <223> RXN00410 <400> 297 gtgttgatqc gttagtccac ccacgcagct acqocccaaa gga. cacagataac qctccqccgg tcctttcagc ccaagatctc atq ataatct tgaacoctgc atq gqa Ci y t cc Ser act Thr gtg Val1 aag Lys ttc Ph e ttg Le u aco t ca Ser gao Asp ctg Len aca Thr cgt Arcj aac Asri cgt Arg agt gaa Gin tgg T rp cag Gin aac Asn aag Lys gtg Val1 gog Al a ttg ctc Leu atg Met gga Gly atc Ile a og Thr tog Ser gtq Val 110 aat Met Met 1 att. tct Ile Ser tca ggc Ser Gly cag cca Gin Pro agc too Ser Ser ago atq Ser Met gao aat Asp Asn cag tgg Gin Trp ato tat gga Ile Tyr Gly gta cag att Val Gin Ile tct ggc aaa Ser Gly Lys acc tca ggc Thr Ser Gly ctq toa gaa Len Ser Glu gtg ttt cag Val Phe Gin att. ttg ctg Ile Leu Len 100 ttt gaa cac Phe Gin His 115 atg cgo oat ttg Oct ggg Ile Thr Ser Val Leu Lys Ile Asp Asn Arg Met Arg His Leu Pro Gly 120 125 130 gag ctg tet ggc qgt eag caa caa cgc gee gcg att gee cgg gcg ttg 540 Giu Leu Ser Gly Gly Gin Gin Gin Arg Ala Ala Ile Ala Arg Ala Leu 135 140 145 atg tct agg ccc gat att gtc att gcg gat gag cca aca gga agt ttg 595 Met Ser Arg Pro Asp Ile Val Ile Ala Asp Giu Pro Thr Gly Ser Leu 150 155 160 165 gat tcc gtc acc age gat gca qtg ttg aat ttg ttc cgc agc att gtt 643 Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu Phe Arg Ser Ile Val 170 175 180 gat gat ttt ggg cag tea ctt gtg ttt gtc acc cac gat aaa gat gct 691 Asp Asp Phe Gly Gin Ser Leu Val Phe Val Thr His Asp Lys Asp Ala 185 190 195 get cac cgt ggt gac gtg ttg ate aca atg cgt gat ggc aag atc ate 739 Ala His Arg Gly Asp Vai Leu Ile Thr Met Ary Asp Gly Lys Ile Ile 200 205 210 gat acg gee gat ttg egg gtg ggg cgt taatgttcag gcttgctttc 786 Asp Thr Ala Asp Leu Arg Vai Gly Arg 215 220 get 789 <210> 298 <211> 222 <212> PRT <213> Corynebacterium glutainicum <400> 298 Met Met Ile Tyr Gly Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly 1 5 10 Ile Ser Val Gin Ile Gin Ser Asp Lys Trp Thr Ser Ile Met Gly Gin 25 Ser Gly Ser Gly Lys Thr Thr Leu Leu Gin Cys Leu Ser Gly Leu Aia 40 Gin Pro Thr Ser Gly Arg Val Thr Leu Asn Lys Asn Asn Ile Thr Leu 55 Ser Ser Leu Ser Giu Asn Lys Arg Ala Lys Leu Arg Arg Thr His Ile 70 75 Ser Met Val Phe Gin Asp Phe Asn Leu Val Pro Ile Leu Ser Vai Lys 90 Asp Asn Ile Leu Leu Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys 100 105 110 Gin Trp Phe Glu His Ilie Thr Ser Val Leu Lys Ile Asp Asn Arg Met 115 120 125 Arg His Leu Pro Gly Giu Leu Ser Gly Gly Gin Gin Gin Arg Ala Ala 135 140 Ala Arg Ala Leu Ser Arg Pro Asp Ile 155 Val Ile Ala Asp Giu 160 Pro Thr Gly Ser Asp Ser Val Thr Asp Ala Val Leu Asn Leu 175 Phe Arg Ser His Asp Lys 195 Ile 180 Val Asp Asp Phe Gly Gin Ser Leu Val 185 Phe Val Thr 190 Thr Met Arg Asp Ala Ala His Gly Asp Val Leu Asp Gly 210 Lys Ile Ile Asp Thr 215 Ala Asp Leu Arg Val Gly Arg 220 <210> 299 <211>. 789 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(766) <223> FRXA00410 <400> 299 gtgttgatgc gttagtceae ccaegeaget aegccccaaa ggaataatct tgaaccctgc cacagataac gctccgccgg tcctttcage ccaagatctc atg atg ate tat Met Met Ile Tyr 1 aaa gga tea aca Lys Gly Ser Thr gtt egg get etc Val Arg Ala Leu ga t Asp gqc att tct gta Giy Ile Ser Val eag att Gin Ile 163 eag tee gae Gin Ser Asp aea aet etg Thr Thr Leu aaa Lys tgg ace tee ate Trp Thr Ser Ile ggg caa tea gge Gly Gin Ser Gly tet gge aaa Ser Gly Lys ttg eag tqe ett tee gga ttg geg eag eea ace tea gge Leu Gin Cys Leu Ser Gly Leu Ala Gin Pro Thr Ser Gly aga gtg Arg Va 1 aca etg aae aaa Thr Leu Asn Lys aae ate aeg ttg Asn Ile Thr Leu tee etg tea gaa Ser Leu Ser Glu aat Asn aag egt gee aag Lys Arg Ala Lys ctg Leu egt egc aeg cac Arg Arg Thr His age atg gtg ttt Ser Met Val Phe gat tte aae ttg Asp Phe Asn Leu ect att ttg teg Pro Ile Leu Ser gtg Val1 aag gae aat att Lys Asp Asn Ile ttg etg Leu Leu 100 ceg ttg egt ett geg eat ege agg gtg gat aag eag tgg ttt gaa eac Pro Leu Arg Leu Ala His Arg Arg Vai Asp Lys Gin Trp Phe Gin His 105 110 atc acc agt gtg ttg aag att gat aat Ile Thr Ser Val Leu Lys Ile Asp Asn 120 125 gag ctg tct ggc ggt cag caa caa cgc Glu Leu Ser Gly Gly Gin Gin Gin Arg 135 140 atg tct agg ccc gat att gtc att gcg Met Ser Arg Pro Asp Ile Val Ile Ala 150 155 gat tec gtc ace age gat gca gtg ttg Asp Ser Val Thr Ser Asp Ala Val Leu 170 gat gat ttt ggg cag tea ctt gtg ttt Asp Asp Phe Gly Gin Ser Leu Val Phe 185 190 get cac cgt ggt gac gtg ttg atc aca Ala His Arg Gly Asp Val Leu Ile Thr 200 205 gat acg gca gat ttg egg gtg ggg cgt Asp Thr Ala Asp Leu Arg Val Gly Arg 215 220 gct <210> 300 <211> 222 <212> PRT <213> Corynebacterium glutamicum <400> 300 Met Met Ile Tyr Gly Lys Gly Ser Thr 1 Ile Ser Val Gin Ile Gin Ser Asp Lys 25 Ser Gly Ser Gly Lys Thr Thr Leu Leu 40 Gin Pro Thr Ser Gly Arg Val Thr Leu 55 Ser Ser Leu Ser Glu Asn Lys Arg Ala 70 Ser Met Val Phe Gin Asp Phe Asn Leu Asp Asn Ile Leu Leu Pro Leu Arg Leu 100 105 Gin Trp Phe Glu His Ile Thr Ser Val 115 cgt atg cgc cat ttg cct Arg Met Arg His Leu Pro 130 gcc gcg att gcc egg gcg Ala Ala Ile Ala Arg Ala 145 gat gag cca aca gga agt Asp Glu Pro Thr Gly Ser 160 aat ttg ttc cgc age att Asn Leu Phe Arg Ser Ile 175 180 gtc ace cac gat aaa gat Val Thr His Asp Lys Asp 195 atg cgt gat ggc aag ate Met Arg Asp Gly Lys Ile 210 taatgttcag gcttgctttc 499 547 595 643 691 739 789 Val Thr Cys Lys Leu Pro His Lys Arg Ser Leu Asn Arg Ile Arg Ile Ala Ile Ser Asn Arg Leu Arg Asp Leu Met Gly Ile Thr Ser Val 110 Asn 115 120 Arg His Leu Pro Gly Giu Leu Ser Giy Gly Gin 130 135 Ile Ala Arg Ala Leu Met Ser Arg Pro Asp Ile 145 150 155 Pro Thr Gly Ser Leu Asp Ser Val Thr Ser Asp 165 170 Phe Arg Se Ile Val Asp Asp Phe Giy Gin Ser 180 185 His Asp Lys Asp Ala Ala His Arg Gly Asp Val 195 200 Asp Gly Lys Ile Ile Asp Thr Ala Asp Leu Arg 210 215 <210> 301 <211> 1500 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(1477) <223> RXN00456 <400> 301 ctcaccaacc cggagatcgt cacagcggtg ctaacggatc Gin 140 Val1 Ala Leu Leu ValI 220 Al a Asp Asn 175 ValI Met atgcctagct, tatggcgtgc tcgtcqcaga cttttqctca ttqccctagg tgtacttqgt qtg ctg cag qca ctg ctg Le u cga Arg gcg Ala gtg Val1 aat As n acc Thr atc Ile ctt Le u tgg Trp gag Giu gcc Ala gtg ValI atg Met gtt Val1 att I le gtg Val1 tcg Ser cgc Arg gtg Val gga Gly caa Gin cgt Arg ttg Leu aat Asn ttg Leu ct g Leu gta Val gaa Glu qt g Val1 gtg ValI agc Set ct t Leu gtq Val1 45 ttg Leu act Thr gc t Ala gcc Al a 15 acc Thr gaa Glu gg t Gi y acc Thr ggC Gi y 95 ValI 1 ata Ile t tg Leu cta Le u gcg Ala gcc Al a gtt Val1 Leu ctt Leu ggt Gly 9gC Gly ctg Leu agc S er ccg Pro Gin gag Giu ttg Le u cag Gin gt g Val1 aat As n atg Met Al a gga Gly ggg Gly cat His cct Pro gat Asp gt C Val 100 Leu aac As n qtg Val1 tat Tyr gga Gly ctc Le u acc Th r 115 163 211 259 307 355 403 ggg ctg Cc Gly Leu Pro ctc cgc aca Leu Arg Thr 120 att gog att gtg Ile Ala Ile Val gtg gcg ttg ttt Val Ala Leu Phe atc caa gat Ile Gin Asp 115 tgt gta gc Cys Val Ala ggc gtg got gtt Gly Val Ala Val gtg coa ctg otc Val Pro Leu Leu gtg ctg Val Leu 135 ccq gtg gtg gcg Pro Vai Vai Ala tgg act ttg aaa Trp Thr Leu Lys aga Arg 145 gca cgt gaa cta Ala Arg Glu Leu cgc Arg 150 aaa aaa cgt gga Lys Lys Arg Gly 090 Arg 155 atg gct gog cgg Met Ala Ala Arg a to Ile 160 gca gat tct gtc Ala Asp Ser Val gct gga gaa tta Ala Gly Giu Leo ctg Leu 170 cac gca aca gga His Ala Thr Gly ata gao cgt gag Ile Asp Arg Giu otc aat Leu Asn 180 gca gtc acc Ala Val Thr too tgg OCc Ser Trp Ala 200 gat too gao oga Asp Ser Asp Arg gtg ata got got Val Ile Ala Ala gta aga ogt Val Arg Arg 195 goa goc tog Ala Ala Ser acc ggt ttt agc Thr Gly Phe Ser 09 C Arg 205 gca ttg atg 900 Ala Leu Met Ala atg Met 210 ott ggc Leu Gly 215 act gtc ago att Thr Val Ser Ile att tot ggc oao Ile Ser Gly His gaa qta agt gag Glu Val Ser Glu gog gga ata atg Ala Gly Ile Met ott ott ggc gtt Leu Leu Gly Val ott Leu 240 900 act oca gtt Ala Thr Pro Val goa Al a 245 gaa ott ggo ogo Giu Leu Gly Arg gtg Val1 250 gtg gaa tat ogo Val Glu Tyr Arg aat tat aaa 900 Asn Tyr Lys Ala 909 aca Ala Thr 260 oqo atc otg Arg Ile Leu oaa oaa aaa Gin Gin Lys 280 oca ott ctg oaa Pro Leu Leu Gin 990 toa gaa ttt Giy Ser Glu Phe aaa oao tco Lys His Ser 275 000 ggt gto Pro Giy Val ota 000 999 ttg Leu Pro Gly Leu oaa Gin 285 goa aoa gaa gga Ala Thr Glu Gly ato Ile 290 tat gto Tyr Val 295 aaa ggt att too Lys Gly Ile Ser ott cot gqa gaa Leu Pro Gly Glu ato tao oto cac Ile Tyr Leo His 990 Gly 310 tot goa gat 909 Ser Ala Asp Ala aga aaa tgg gto Arg Lys Trp Val aco Thr 320 tog ttg tot goa Ser Leo Ser Ala 1027 1075 1123 gag gaa 990 aca Glu Glu Gly Thr ga t Asp 330 gta ata gtc aac Val Ile Val Asn oaa agg ott tog Gin Arg Leo Ser cag ott Gin Leu 340 cct ttg aaa caa cga cgC gcc ctc Pro Leu Lys Gin Arg Arg Ala Leu 345 cac tta agc cgt ggt tca gta tcg His Leu Ser Arg Gly Ser Val Ser 360 365 gat gcc acc qtg gaa gaa att gag Asp Ala Thr Val Giu Giu Ile Gin 375 380 aac aac acc ggg aaa caa cgc ttg Asn Asn Thr Gly Lys Gin Arg Len 390 395 act tcg cag atc aac aaa ctg aaa Thr Ser Gin Ile Asn Lys Leu Lys 410 cca ccg ctt ttg gta ctt gaa ggc Pro Pro Leu Leu Val Leu Gin Gly 425 tat ccc gqa qtg atc atc tcc acc Tyr Pro Gly Val Ile Ile Ser Thr 440 445 tgg cgg caa gtg aac atc taatctag Trp Arq Gin Val Asn Ile 455 <210> 302 <211> 459 <212> PRT <213> Corynebacteriun giutamicum <400> 3d2 Val Leu Gin Ala Leu Leu Aia Ile 1 5 Ile Leu Gin Giy Asn Arg Ala Leu Leu Gly Len Giy Vai Ala Gin Trp 40 Leu Gly Gin His Tyr Val His Gin Ala Leu Val Pro Giy Asn Thr Ala Ala Ser Asn Asp Leu Thr Ala Val Val Pro Met Vai Thr Gly Leu Pro 100 Leu Phe Ile Gin Asp Leu Arg Thr atc Ile 350 cgc Arg caa Gin aaa Lys att Ile atc Ile 430 gtt Val1 gga Gly ctg Le u gca Ala As n gcc Al a 415 acc Thr cag Gin atc Ile gtt Val1 ctg Leu g gc Gly 400 agc Ser cct Pro gag Glu gcc tca gca Ala Ser Ala 355 ggt ttg cga Gly Len Arg 370 gaa caa gtt Gin Gin Val 385 gga cac ccc Giy His Pro gcc acc ctt Ala Thr Leu gaa aac ctc Giu Asn Leu 435 aac cca tcc Asn Pro Ser cac His gtg Val1 ggt Gly V.gg Trp cga Arg 420 ctc Leu g aa Glu cac His c cg Pro ctg Leu agt Se r 405 acc Thr aac As n aca Thr 1171 1219 1267 1315 1363 1411 1459 aa acatggcagg acg 1500 Val1 Ile Val1 Ser Arg Len 105 Ser Len Val1 Len Thr Ala Val1 Thr Ala Thr Gin Gly Thr Gly Val1 Pro 115 120 125 Leu Met Cys Val Ala Val Leu Pro Val Val Ala Arg Trp Thr Leu Lys 130 135 140 Arg Ala Arg Glu Leu Arg Lys Lys Arg Gly Arg Met Ala Ala Arg Ile 145 150 155 160 Ala Asp Ser Val Met Ala Gly Glu Leu Leu His Ala Thr Gly Ala Ile 165 170 175 Asp Arg Glu Leu Asn Ala Val Thr Arg Asp Ser Asp Arg Val Val Ile 180 185 190 Ala Ala Val Arg Arg Ser Trp Ala Thr Gly Phe Ser Arg Ala Leu Met 195 200 205 Ala Met Ala Ala Ser Leu Gly Thr Val Ser Ile Val Ile Ser Gly His 210 215 220 Leu Glu Val Ser Glu Val Ala Gly Ile Met Met Leu Leu Gly Val Leu 225 230 235 240 Ala Thr Pro Val Ala Glu Leu Gly Arg Val Val Giu Tyr Arg Gin Asn 245 250 255 Tyr Lys Ala Ala Thr Arg Ile Leu Ile Pro Leu Leu Gin Arg Gly Ser 260 265 270 Glu Phe Lys His Ser Gin Gin Lys Leu Pro Gly Leu Gin Ala Thr Glu 275 280 285 Gly Ile Pro Gly Val Tyr Val Lys Gly Ile Ser Ala Leu Pro Gly Glu 290 295 300 Ar Ile Tyr Leu His Gly Ser Ala Asp Ala Thr Arg Lys Trp Val Thr 305 310 315 320 Ser Leu Ser Ala Met Glu Glu Gly Thr Asp Val Ile Val Asn Gly Gin 325 330 335 Arg Leu Ser Gin Leu Pro Leu Lys Gin Arg Arg Ala Leu Ile Gly Ile 340 345 350 Ala Ser Ala His His His Leu Ser Arg Gly Ser Val Ser Arg Leu Val 355 360 365 Gly Leu Arg Val Pro Asp Ala Thr Val Glu Glu Ile Glu Gin Ala Leu 370 375 380 Glu Gin Val Gly Leu Asn Asn Thr Gly Lys Gin Arq Leu Lys Asn Gly 385 390 395 400 Gly His Pro Trp Ser Thr Ser Gin Ile Asn Lys Leu Lys Ile Ala Ser 405 410 415 Ala Thr Leu Arg Thr Pro Pro Leu Leu Val Leu Giu Gly Ile Thr Pro 420 425 430 Glu Asn Leu Leu Asn Tyr Pro Gly Val Ile Ile Ser Thr Val Gin Glu 435 440 445 Asn Pro Ser Glu Thr Trp Arg Gin Val Asn Ile 450 455 <210> 303 <211> 412 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(412) <223> FRXA00456 <400> 303 ctcaccaacc cggagatcgt cacaqcggtg ctaacqgatc atgcctaqct tatggcgtgc tcgtcgcaga cttttgctca ttqccctagg tgtacttggt. gtg ctg cag ctg Leo cga Arg gcg Al a gtg Val1 aa t As n acc Thr ggg Gly a tq Met gt t Val att Ile gt g Val1 t cq Ser cgc Arg gtg Val1 gga Gly caa Gin cgt Arg ttg Leui aat Asn agc Ser ct t Leo gt g Val1 ttg Le u act Thr gct Aila gcc Al a acq Th r gat Asp gct Al a cga Arg 80 att. Ile Val Leo Gin 1 ata ctt gag Ile Leu Glu ttg ggt ttg Leu Gly Leu cta qqc cag Leu Gly Gin gcg ctg gtg Ala Leo Val gcc agc aat Ala Ser Asn gtt ccg atg Val Pro Met gca ctg Ala Leo gga aac Gly Asn ggg gtg Gly Val cat tat His Tyr cct gqa Pro Gly gat ctc Asp Leu gtc acc Val Thr 100 <210> 304 <211> 104 <212> PRT <213> Corynebacterium glutamicum <400> 304 Val Leu Gin Ala Leu Leo Ala Ile Met Val Ser Leo Ser Val Ala Ala 1 5 10 Ilie Leo Glu Gly Asn Arg Ala Leo Val Gly Leo Leo Leo Ala Thr Thr 25 Leu Giy Leu Gly Val Ala Gin Trp Ile Gin Lys Val Vai Ala Glu Asp 40 Leu Gly Gin His Tyr Val His Giu Val Arg Arq Giu Leu Val Giy Ala 55 Ala Leu Val Pro Gly Asn Thr Ala Ser Leu Gly Vai Thr Val Thr Arg 70 75 Ala Ser Asn Asp Leu Thr Ala Val Arg Asn Trp Vai Ala Leu Gly Ile 90 Val Pro Met Val Thr Giy Leu Pro 100 <210> 305 (211> 1040 '<212> DNA <213> Corynebacterium giutamioum <220> <221> COS <222> (31)..(1017) <223> FRXA00459 <400> 305 aggcgtggct gttactgtgo cactgotcat gtg tgt acc cgt got gcc qqt ggt 54 Vai Cys Thr Arg Ala Ala Gly Gly 1 ggc gog gtg act ttg aaa aga gca cgt gaa cta cgc aaa aaa cgt gga 102 Gly Ala Val Thr Leu Lys Arg Ala Arg Giu Leu Arg Lys Lys Arg Gly 15 cgc atg gct gcg cgg atc goa gat tot gto atg got gga gaa tta ctg 150 Arg Met Ala Ala Arg Ile Ala Asp Ser Val Met Ala Gly Giu Leu Leu 30 35 cac gca aca gga, gca ata gac cgt gag cto aat gca gtc acc cga gat 198 His Ala Thr Gly Ala Ile Asp Arg Giu Leu Asn Ala Val Thr Arq Asp 50 toc gao oga qtq gtg ata got got gta aga cgt too tgg goc acc ggt 246 Ser Asp Arg Val Val Ile Ala Ala Val Arg Arg Ser Trp Ala Thr Gly 65 ttt ago cgc gca ttg atg gcc atg gca gcc tog ott ggc act gto ago 294 Phe Ser Arg Ala Leu Met Ala Met Ala Ala Ser Leu Gly Thr Val Ser 80 att gtg att tot ggo cac otg gaa gta agt gag gtt gog gga ata atg 342 Ile Val Ile Ser Gly His Leu Giu Val Ser Glu Val Ala Gly Ile Met 95 100 atg ott ott ggo gtt ott goc act cca gtt gca gaa ott ggc ogo gtg 390 Met Leu Leu Gly Val Leu Ala Thr Pro Val Ala Glu Leu Gly Arg Val 105 110 115 120 gtg gaa tat cgc Val Giu Tyr Arg ca a Gin 125 aat tat aaa gcc Asn Tyr Lys Ala aca cgc atc ctg Thr Arg Ile Leu att cca Ile Pro 135 (Nctt Ctg caa Leu Leu Gin ~±ggg ttg caa C1 Gly Leu Gin 155 cga Arg *140 ggc tca gaa ttt Gly Ser Giu Phe cac tcc oaa caa His Ser Gin Gin aaa cta ccc Lys Leu Pro 150 aaa ggt att Lys Gly Ile 486 534 gca aca gaa gga Ala Thr Giu Gly atc Ile 160 ccc ggt gtc tat Pro Gly Vai Tyr tcc gcc Ser Ala 170 ott cot gga gaa Leu Pro Gly Giu atc tac ctc cac Ile Tyr Leu His ggc Giy 180 tot gca gat gog Ser Ala Asp Ala aga aaa tgg gtc Arg Lys Trp Vai ac Thr 190 tog ttg tct goa Ser Leu Ser Ala gag gaa ggc aca Giu Giu Gly Thr gta ata gtc aac Val Ile Val Asn oaa agg ctt tog Gin Arg Leu Ser ott cct ttg aaa Leu Pro Leu Lys caa cga Gin Arg 215 cgo gcc otc Arg Ala Leu toa gta tog Ser Vai Ser 235 atc Ile 220 gga atc gcc tca Gly Ile Ala Ser gca Ala 225 cac cac cac tta His His His Leu agc cgt ggt Ser Arg Giy 230 acc gtg gaa Thr Val Giu cgc ctg gtt ggt Arg Leu Val Gly ttg Leu 240 cga gtg cog gat Arg Val Pro Asp gaa att Giu Ile 250 gag caa gca ctg Glu Gin Ala Leu gaa Giu 255 caa gtt ggt ctg Gin Val Gly Leu aac As n 260 aac acc ggg aaa Asn Thr Gly Lys caa Gin 265 cgo ttg aaa aac Arg Leu Lys Asn ggc Gly 270 gqa oao ccc tgg Gly His Pro Trp act tog cag ato Thr Ser Gin Ile aaa ctg aaa att Lys Leu Lys Ile ago goc aco ott Ser Ala Thr Leu aoo oca cog ctt Thr Pro Pro Leu ttg gta Leu Val 295 ott gaa qgc Leu Giu Gly ato too ac Ile Ser Thr 315 ato Ile 300 aco cot qaa aac Thr Pro Giu Asn oto aao tat ccc Leu Asn Tyr Pro gga gtg ato Gly Val Ile 310 oaa gtg aao Gin Val Asn 966 1014 gtt cag gag aac Val Gin Giu Asn oca Pro 320 too gaa aoa tgg Ser Glu Thr Trp ato Ile taatctagaa acatggcagg acg 1040 <210> 306 <211> 329 <212> PRT <213> Corynebacterium giutamioum <400> 306 Val Cys Thr Arg Ala Ala Gly Gly Gly Ala Val Thr Leu Lys Arg Ala 1 5 10 Arg Glu Leu Arg Lys Lys Arg Gly Arg Met Ala Ala Arg Ile Ala Asp 25 Ser Val Met Ala Gly Giu Leu Leu His Ala Thr Gly Ala Ile Asp Arg 40 Giu Leu Asn Ala Val Thr Arg Asp Ser Asp Arg Val Val Ile Ala Ala so 55 Val Arg Arg Ser Trp Ala Thr Gly Phe Ser Arg Ala Leu Met Ala Met 70 75 Ala Ala Ser Leu Gly Thir Val Ser Ile Val Ile Ser Gly His Leu Giu 90 Val Ser Glu Val Ala Gly Ile Met Met Leu Leu Gly Val Leu Ala Thr 100 105 110 Pro Val Ala Glu Leu Gly Arg Val Val Giu Tyr Arg Gin Asn Tyr Lys 115 120 125 Ala Ala Thr Ar Ile Leu Ile Pro Leu Leu Gin Arg Gly Ser Glu Phe 130 135 140 Lys His Ser Gin Gin Lys Leu Pro Gly Leu Gin Ala Thr Glu Gly Ile 145 150 155 160 Pro Gly Val Tyr Val Lys Gly Ile Ser Ala Leu Pro Gly Glu Arg Ile 165 170 175 Tyr Leu His Gly Ser Ala Asp Ala Thr Arg Lys Trp Val Thr Ser Leu 180 185 190 Ser Ala Met Giu Glu Gly Thr Asp Val Ile Val Asn Giy Gin Arg Leu 195 200 205 Ser Gin Leu Pro Leu Lys Gin Arg Arg Ala Leu Ile Gly Ile Ala Ser 210 215 220 Ala His His His Leu Ser Arg Gly Ser Val Ser Arg Leu Val Gly Leu 225 230 235 240 Arg Val Pro Asp Ala Thr Val Glu Glu Ile Giu Gin Ala Leu Glu Gin 245 250 255 Val Gly Leu Asn Asn Thr Gly Lys Gin Arg Leu Lys Asn Gly Giy His 260 265 270 Pro Trp Ser Thr Ser Gin Ile Asn Lys Leu Lys Ile Ala Ser Ala Thr 275 280 285 Leu Arg Thr Pro Pro Leu Leu Val Leu Giu Gly Ile Thr Pro Giu Asn 290 295 300 Leu Leu Asn Tyr Pro Gly Val Ile Ile Ser Thr Vai Gin Glu Asn Pro 305 310 315 320 Ser Glu Thr Trp Arg Gin Val Asn Ile 325 <210> 307 <211> 771 <212> DNA <213> Corynebacterium glutamioum <220> <221> CDS <222> (101) (7 48) <223> RXN01604 <400> 307 ctctcatgtt gttgtcctct agttgaoagc gggggtggtg gtggtcctaa aatagcctac gataactgat agtgtttcct ccacttacgg aagaagatac atg aat acc cot Ott Met Asn Thr Pro Leu ttg aqa ago tct Leu Arg Ser Ser ggg Gly oto too ato ogo gao aoa 000 tto gc Leu Ser Ile Arg Asp Thr Pro Phe Ala 15 gat gtt Asp Val gag ata got Glu Ile Ala too oaa too Ser Gin Ser gao ago gga cto Asp Ser Gly Leu ttg otg ago acc Leu Leu Ser Thr ggg ogo gaa Gly Arg Glu atg ogo goo Met Arg Ala agt too ttt tot Ser Ser Phe Ser ttg Le u gta ott too ggo Val Leu Ser Giy too aco Ser Thr gga aco ato gaa Gly Thr Ile Glu aao go gaa ccc Asn Gly Giu Pro atc aag goa aco aag Ile Lys Ala Thr Lys gaa ato gat toa oto Giu Ile Asp Ser Leu goo aag oat gtg Ala Lys His Val ttg gog ggo ato Leu Ala Gly Ile 307 355 403 gag oga ott gto Giu Arg Leu Val acot Thr gtg ogo aoo gtt Val Arg Thr Val ogt gaa oaa oto Arg Giu Gin Leu goo tgg Ala Trp 100 toa ago cot Ser Ser Pro ogg tgg gtt Arg Trp Val 120 tao otg atg gtg Tyr Leu Met Val 000 agg Pro Arg 110 gat att agt Asp Ile Ser gat tog gga Asp Ser Gly 115 aao cot aaa Asn Pro Lys gao gto gaa aaq oat ott qgc otg aao Asp Val Giu Lys His Leu Gly Leu Asn aoc tta Thr Leu 135 ato ggo gao oto Ile Gly Asp Leu gtg oto gag ogt Val Leu Giu Arg aag ctg ogo ato Lys Leu Arg Ile 499 547 595 go g Ala 150 otg gog otg otg Leu Ala Leu Leu ogg ooa gag gog Arg Pro Glu Ala oaa Gin 160 otg ttg gto gtg Leu Leu Val Val ga t Asp gca Al a aac As n ccc gat Pro Asp ttg aaa Leu Lys cca gat Pro Asp 200 caa qtq cgc agc atq gaa ttg cgt gcg gag gtg ttg cac Gin Val Arg Ser Met Glu Leu Arg Ala Glu Val Leu His 170 175 180 ggc gtt gca gag gat ctc cct gtg gtc gtg qta tcc acc Gly Val Ala Glu Asp Leu Pro Val Val Val Val Ser Thr 185 190 195 ttt gat tcc ttg gcc gat acc gct ttg acc att acg ggg Phe Asp Ser Leu Ala Asp Thr Ala Leu Thr Ile Thr Gly 205 210 taatqgcatt tttacacttt ggc gct gqa aac Ala Gly Asn 215 <210>' 308 <211> 216 (212> PRT <213> Corynebacterium glutamicum <400> 308 Met Asn Thr Pro Leu Leu Arg Ser Ser 1 Pro Ser Gly Ile Glu Glu Ile Asn Phe 145 Leu Al a Val Al a Gi y Met Ala Asp Leu Asp 115 As n Le u Val1 ValI Val Asp Arg Arg Thr Ser Ala 100 Ser Pro Arg ValI Leu 180 Ser 5 Val Giu Ala Lys Leu T rp Gly Lys Ile Asp 165 His Thr Glu Ser Ser Leu Glu Ser Arg Thr Ala 150 Asp Ala As n Ala Ser 40 Gi y Lys Leu Pro Val1 120 Ile Al a Asp Lys Asp Pro 25 Se r Thr His Val1 Trp 105 Asp Gly Le u Gin Gi y 185 Ph e Gly Asp Ser Ile Val Thr T yr Val1 Asp Leu Val1 170 Val1 Asp Ser Gly Ser Le u Leui Arg Met Lys Ser 140 Arg Ser Giu Leu Ile Leu Leu Asn Ala Thr Val1 His 125 Val1 Pro Met Asp Ala Arg Thr Val1 Gly Gi y Val1 Pro 110 Leu Le u Glu Glu Le u 190 Asp 200 Leu Thr Ile Thr Gly Ala Gly Asn 210 215 <210> <211> <212> <213> <220> <z221> <:222> <22 3> 309 629 DNA Corynebacterium giutamicum C DS FRXA01 604 <400> 309 gac aca ccc ttc gcc gat gtt gag ata Asp Thr Pro Phie Ala Asp Val Giu Ile 1 5 cca gac aqc gga Pro Asp Ser Gly ctc act Leu Thr ttg ctg agc Leu Leu Ser ctt tcc ggo Leu Ser Gly ggg ogc gaa too Gly Arg Glu Ser tcc agt tco ttt Ser Ser Ser Phe tot ttg gta Ser Leu Val tta aac ggc Leu Asn Gly cgc atg cgc gcc Arg Met Arg Ala tcc Se r aoc gga acc ato Thr Gly Thr Ile gaa ccc Glu Pro atc aag gca aco Ile Lys Ala Thr aag Lys otg 900 aaq cat Leu Ala Lys His got ttg gog ggc Ala Leu Ala Gly ato Ile cot qaa ato gat Pro Giu Ile Asp toa Ser 70 oto gag oga ott Leu Giu Arg L~u gto Val1 aot gtg ogo ac Thr Val Arg Thr 192 240 288 gtc ogt gaa caa Val Arg Giu Gin goc tgg toa. ago Ala Trp Ser Ser tgg tao otg atg Trp Tyr Leu Met gtg coo Val Pro agg gat att Arg Asp Ilie ggc ctg aac Gly Leu Asn 115 gat tog gga cgg Asp Ser Gly Arg gtt gao gto gaa Val Asp Val Glu aag cat Ott Lys His Leu 110 ago gtg ctc Ser Val Leu ctg aac cot aaa Leu Asn Pro Lys aco Thr 120 tta ato ggc gao Leu Ile Gly Asp gag cgt Giu Arg 130 ttt aag otg ogo Phe Lys Leu Arg gog ctg gog otg otg gog ogg coa gag Ala Leu Ala Leu Leu Ala Arg Pro Glu 140 9gg Ala 145 caa otg ttg gto Gin Leu Leu Val gtg Val1 150 gat gat coo Asp Asp Pro gat oaa Asp Gin 155 aaa go Lys Gly 170 gtg ogo ago atg Val Arg Ser Met ga a Giu 160 ttg ogt gog gag Leu Arg Ala Glu ttg cac goa ttg Leu His Ala Leu gtt gca gag Val Ala Giu gat oto Asp Leu 175 cct gtg gtc gtg gta tcc acc aac cca gat ttt gat tcc ttg gcc gat Pro Val Val. Val Val Ser Thr Asn Pro Asp Phe Asp Ser Leu Ala Asp 180 185 190 acc gct ttg acc att acg ggg gct gga aac taatggcatt tttacacttt Thr Ala Leu Thr Ile Thr Gly Ala Gly Asn 195 200 ggc <210> 310 <211> 202 <212> PRT <213> Corynebacterium glutamicun <400> 310 Asp Thr Pro Phe Ala Asp Val Glu Ile 1 Leu Leu Giu Ile Val Arg Gly Glu Ala 145 Le u Pro Thr Leu Ser Pro Pro Arg Asp Le u Arg 130 Gin Arg Val1 Al a Thr Arg Lys Ile Gln Ser 100 Le u Lys Le u Gi u Val1 180 Th r Arg Arg Thr Ser 70 Ala Ser Pro Arg Val1 150 Leu Ser Thr Glu Ala Lys 55 Le u T rp Gly Lys Ile 135 Asp His Thr Gly Gin 25 Th r Al a Arg Se r Trp 105 Le u Le u Pro Leu Pro 185 Gly Ala 10 Ser Gly Lys Leu Pro ValI Ile Ala Asp Lys 170 Asp Asn Pro Ser Thr His Val1 75 T rp Asp Gly Leu Gin 155 Gly Phe Asp Ser Ile Val1 Thr Tyr ValI Asp Leu 140 Val1 Val Asp Ser Phe Glu Ala Val1 Leu Glu Leu 125 Ala Arg Al a Ser Gly Ser Leu Leu Arg Met Lys 110 Ser Arg Ser Giu Le u 190 Leu Leu As n Ala Thr Val His ValI Pro Met Asp 175 Ala Thr Val1 Gly Gly Val1 Pro Leu Le u Glu Gi u 160 Leu Asp <210> 311 <211> 2262 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(2239) <223> RXN02547 <400> 311 ggggccgtcg ataagcgaag aacaattagc actgcgcgcg aggggctggc ggtccggcgc cggaatcggc ggaggagctt ctggtctgac gcattggtta ttg gag ctc aac aac 11! Leu Glu Leu Asn Asn gct gcg Cgg ctg Ala Ala Arg Leu acc Thr gtq gat gag tat Val Asp Giu Tyr gcg gcg agg gaa Ala Ala Arg Giu gog ott Ala Leu gaa tct gca Giu Ser Ala gag tto aaa Giu Phe Lys ggt Gly cag agg aat gta Gin Arg Asn Val gac cga acc cgt Asp Arg Thr Arg gcg gtt gat Ala Val Asp aaa qgc ago Lys Gly Ser gcg gcg gat caa Ala Ala Asp Gin gag Giu 45 ctg tct tct ttg Leu Ser Ser Leu agt Ser agt aat Ser Asn att gag tac cgt Ile Glu Tyr Arg ctg cag gtg cgg Leu Gin Val Arg aat ttg tgt cag Asn Leu Cys Gin gat Asp ttg qgc gtg agc Leu Gly Val Ser cgg gat atg ccc Arg Asp Met Pro ttt Phe 80 goc ggt gag ctg Ala Gly Giu Leu att Ile gat cog aat aat Asp Pro Asn Asn gog Ala gaa tgg gaa ccc Glu Trp Giu Pro gtg cag cgc att Val Gin Arg Ile ttg ggt Leu Gly 100 gqt ttt gct Gly Phe Ala cgg gat tgg Arg Asp Trp 120 gaa. atg tty gtt Giu Met Leu Val cat ggg ttg ttg His Gly Leu Leu cca. cgg qtt Pro Arg Val 115 aaa ttc aac Lys Phe Asn 451 499 gta aat goc aaa Val Asn Ala Lys ttg gca gcg ctg Leu Ala Ala Leu ggc gtg Gly Val 135 gtg aca acg ggg Val Thr Thr Gly gag Giu 140 tao aaa acc tog Tyr Lys Thr Ser og t Arg 145 ttt cog gcg gat Phe Pro Ala Asp ctg atc cga. aaa Leu Ile Arg Lys gat gtt gtg gag Asp Val Val Glu cog ttt ogo gat Pro Phe Arg Asp 547 595 643 gta aat caa gaa Val Asn Gin Giu tta Leu 170 ggc aag cgt ttt Gly Lys Arg Phe aa t As n 175 att cgg tgo gtg Ile Arg Cys Val ogc act Arg Thr 180 cot gag gaa Pro Giu Giu tog gog otg ggg Ser Ala Leu Gly ogo gat cag ggc Arg Asp Gin Gly gtg aco att Val Thr Ile 195 ttg ggt gtg Leu Gly Val 200 cga aaa ttt gcg Arg Lys Phe Ala cag aca ggc gat Gin Thr Gly Asp acg acg cgt Thr Thr Arg 739 tgg gaa Trp Glu 215 aaa gat gat cgc Lys Asp Asp Arg cga Arg 220 aag ctg ggg gat Lys Leu Gly Asp cgt Arg 225 tcc aca tac cgt Ser Thr Tyr Arg ggt tcc acc aat Gly Ser Thr Asn ga t Asp 235 gcc aag gtg gaa Ala Lys Val Giu ctt cgg gaa acc Leu Arg Glu Thr aaa gct ggc aaa Lys Ala Gly Lys gca Ala 250 gtt gtg cag gca Val Val Gin Ala gct Al a 255 gat aat cqc att Asp Asn Arg Ile gct gca Ala Ala 260 aac cgc gct Asn Arg Ala gaa att ttg Glu Ile Leu 280 ctg cgg gaa ctt Leu Arg Giu Leu cgg cag tat caa Arg Gin Tyr Gin gct tcg caa Ala Ser Gin 275 tca gcc gac Ser Ala Asp 931 979 aaa gtg tcg tgg Lys Val Ser Trp cag att gat gtg Gin Ile Asp Val gcg gcg Ala Ala 295 att get gag ctg Ile Ala Giu Leu gac Asp 300 cga ttg ctg gaa Arg Leu Leu Glu gag Glu 305 etg aac aac act Leu Asn Asn Thr gag gcc acc gag Giu Ala Thr Glu ctt Leu 315 tcc gcg cgg cat Ser Ala Arg His gcg gcg aag cag Ala Ala Lys Gin 1027 1075 1123 etc gcg agg gtt Leu Ala Arg Val tct Se r 330 gac ttg ctt gtc Asp Leu Leu Val gct cag agt gag Ala Gin Ser Glu gaa ace Giu Thr 340 gtg gcg tcg Val Ala Ser qaa agc ctg Glu Ser Leu 360 aac ctg aaa cgc Asn Leu Lys Arg gcc Al a 350 gaa act gaa ttg Glu Thr Giu Leu aaa cgg etc Lys Arg Leu 355 cgg gaa gtg Arg Giu Val ccg gtt gcg gag Pro Val Ala Giu tct gaa gaa atc Ser Glu Giu Ile gcg Al a 370 gag aaa Giu Lys 375 cta ttt ctt gcc Leu Phe Leu Ala acc cgc cgg gtt Thr Arg Arg Val cac His 385 gcc gcc aac gtg Ala Ala Asn Val 1171 1219 1267 1315 1363 gat Asp 390 gag cag acc att Giu Gin Thr Ile gcg Ala 395 ctg cgc gag gat Leu Arg Glu Asp ctg Leu 400 gac aaa caa atc Asp Lys Gin Ile ga t Asp 405 gcc aat gag gca Ala Asn Glu Ala ctt cga cgt tgt Leu Arg Arg Cys aac caa att gtt Asn Gin Ile Val ggC att Gly Ile 420 ttg egc agc Leu Arg Ser att gaa acg tgg Ile Giu Thr Trp cct Pro 430 gcg aac cgc gct Ala Asn Arg Ala gac tta caa Asp Leu Gin 435 1411 gcc gaa cct gag ttt gtt ggt gag gee ate: aac ege ctc ggc gag ctt 1459 Ala Giu Pro 440 Glu Phe Val Gly Glu 445 Ala Ile Asn Arg Leu 450 Gly Glu Leu ege agc Arg Ser 455 gat cgt ttq gca Asp Arg Leu Ala tte acg gee aaa Phe Thr Ala Lys cta ggg etc atg Leu Gly Leu Met aac Asn 470 gag atg tec ace Glu Met Ser Thr ega Arg 475 aac ctc ggc caa Asn Leu Gly Gin tcg egg cgt eta Ser Arg Arg Leu 1507 1555 1603 gat geg ege egg Asp Ala Arg Arg ate gag gag ege Ile Giu Glu Arg ate Ile 495 gag ceg ate aae Glu Pro Ile Asn ttg gcg cag Leu Ala Gin egt gat eaa Arg Asp Gin 520 gaa tte aae gaa Glu Phe Asn Glu ege ttc ctg eac Arg Phe Leu His ate gac ate Ile Asp Ile 515 aaa ctt gat Lys Leu Asp 1651 1699 agt ggt ceg att Ser Gly Pro Ile gtg Va1 525 agg gaa ttc cag Arg Glu Phe Gin cag Gin 530 gee gct Ala Ala 535 ace agc ggt gac Thr Ser Gly Asp gga ace agt ace Gly Thr Ser Thr aaa caa gee ttc Lys Gin Ala Phe gee Ala 550 cgt tat gcg ctg Arg Tyr Ala Leu ate Ile 555 get gaa ate att Ala Glu Ile Ile aaa etc gee tee Lys Leu Ala Ser gac tee gee gac Asp Ser Aia Asp gee Ala 570 ege tgg ege aac Arg Trp Arg Asn ace Thr 575 gtt cta gac ace Val Leu Asp Thr ege ege Arg Arg 580 cac gtt cgc His Val Arg aae ace tac Asn Thr Tyr 600 ate ggc etc gag Ile Gly Leu Glu ege Arg 590 gat tee gac ggc Asp Ser Asp Gly gca ace gte Ala Thr Val 595 gee cag aag Ala Gin Lys 1747 1795 1843 1891 1939 1987 2035 2083 gtc gac tee gca Val Asp Ser Ala ett tea gge gga Leu Ser Gly Gly etg gtg Leu Val 615 ttt tte tge etc Phe Phe Cys Leu gee Ala 620 get gee ttg ege Ala Ala Leu Arg cag eta gee gaa Gin Leu Ala Glu gqe gee eat tat Gly Ala His Tyr ace tac gec ace Thr Tyr Ala Thr gte Val 640 att ctg gac gaa Ile Leu Asp Glu gee Ala 645 ttc Phe tte gac ege gee Phe Asp Arg Ala gae Asp 650 ccc gee ttc ace Pro Ala Phe Thr caa ace aty aac Gin Thr Met Asn cac age ttc His Ser Phe ggc Gly 665 ttc cac atg gtg Phe His Met Val gcg ace ceg etg Ala Thr Pro Leu aaa ett ate Lys Leu Ile 675 2131 eaa ace etc gge gat tat gte qge tee ace ate gtg gte age tac ace Gin Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile Val Val Ser Tyr Thr 2179 680 685 690 gaa aaa cca aac gcc cag ggc gca att cag ggc aat tcc agt ttc tct 2227 Giu Lys Pro Asn Ala Gin Gly Ala Ile Gin Gly Asn Ser Ser Phe Ser 695 700 705 agg atc gag aaa taacatgcca ttgtttatcg acg 2262 Arg Ile Giu Lys 710 <210> 312 <211> 713 <212> PRT <213> Corynebacterium giutamicum <400> 312 Leu Giu Leu Asn Asn Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala 1 5 10 Ala Arg Glu Ala Leu Giu Ser Ala Gly Gin Arg Asn Val Glu Asp Arg 25 Thr Arg Ala Val Asp Glu Phe Lys Ala Ala Asp Gin Giu Leu Ser Ser 40 Leu Ser Lys Gly Ser Ser Asn Ile Giu Tyr Arg Leu Leu Gin Val Arg 55 Giu Asn Leu Cys Gin Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe 70 75 Ala Gly Giu Leu Ilie Asp Pro Asn Asn Ala Giu Trp Glu Pro Val Val 90 Gin Arg Ile Leu Gly Gly Phe Ala Ala Glu Met Leu Val Pro His Gly 100 105 110 Leu Leu Pro Arg Val Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala 115 120 125 Leu Leu Lys Phe Asn Gly Val Val Thr Thr Gly Giu Tyr Lys Thr Ser 130 135 140 Arg Phe Pro Ala Asp Ser Leu Ile Arg Lys Val Asp Val Val Giu Ser 145 150 155 160 Pro Phe Arcj Asp Trp Val Asn Gin Giu Leu Gly Lys Arg Phe Asn Ile 165 170 175 Arg Cys Val Arg Thr Pro Giu Giu Leu Ser Ala Leu Gly Pro Arg Asp 180 185 190 Gin Gly Val Thr Ile Leu Gly Val Arg Lys Phe Ala Gin Gin Thr Gly 195 200 205 Asp Pro Thr Thr Arg Trp Giu Lys Asp Asp Arg Arg Lys Leu Gly Asp 210 215 220 Arg Ser Thr Tyr Arg Leu Gly Ser Thr Asn Asp Ala Lys Val Giu Thr 225 230 235 240 Leu As n Tyr Val Giu 305 Al a Gin Glu Ile His 385 As p Gin Arg Arg Phe 465 Ser Pro Leu Gin Glu 545 Arg Arg Gin Giu 290 Leu Al a Ser Leu Ala 370 Al a Lys Ile Al a Leu 450 Le u Arg Ile His Gin 530 Lys Glu Ile Al a 275 Ser As n Lys Giu Lys 355 Ar g Al a Gin Val1 Asp 435 Gly Gly Arg As n Ile 515 Lys Gin Thr Al a 260 Ser Ala As n Gin Giu 340 Arg Giu Asn Ile Gly 420 Leu Glu Leu Leu Ala 500 Asp Leu Ala Val1 245 Al a Gin Asp Thr Thr 325 Thr Leu Val Val1 Asp 405 Ile Gin Le u Met Arg 485 Ser Ile Asp Phe Lys Asn Glu Ala Pro 310 Leu Val Glu Glu Asp 390 Ala Leu Ala Arg Asn 470 Asp Le u Arg Ala Ala 55D Ala Arg Ile Ala 295 Glu Al a Al a Ser Lys 375 Giu Asn Arg Giu Ser 455 Giu Al a Al a Asp Ala 535 Arg Gly Al a Leu 280 Ile Al a Arg Ser Leu 360 Leu Gin Glu Se r Pro 440 Asp Met Arg Gin Gin 520 Thr Tyr Lys Glu 265 Lys Al a, Th r Val1 Met 345 Pro Phe Thr Ala Tyr 425 Giu Arg Ser Arg Ser 505 Ser Ser Al a Ala 250 Leu Val1 Giu Glu Ser 330 Asn Val1 Leu Ile Giu 410 Ile P he Leu Thr Giu 490 Glu Gly Gly Leu Vai Arg Ser Leu Leu 315 Asp Leu Ala Ala Ala 395 Leu Giu Val1 Al a Arg 47 5 Ile Phe Pro Asp Ile 555 Val1 Glu Trp Asp 300 Ser Le u Lys Giu As n 380 Leu Arg Thr Gly Giu 460 As n Glu As n Ile Leu 540 Ala Gin Leu Ala 285 Arg Ala Leu Arg Val 365 Thr Arq Arg Trp Glu 445 Phe Leu Giu Giu Val1 525 Gly Giu Ala Glu 270 Gin Leu Arg Val1 Al a 350 Ser Arg Glu Cys Pro 430 Al a Thr Gly Arg Gly 510 Arg Thr Ile Ala 255 Arg Ile Leu His Ala 335 Giu Giu Arq Asp Glu 415 Ala Ile Ala Gin Ile 495 Arg Giu Ser Ile Asp Gin Asp di u Giu 320 Al a Thr Giu Val1 Leu 400 Asn As n As n Lys Ile 480 Giu Phe Phe Thr Se r 560 Lys Leu Ala Ser His Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val 565 570 575 Leu Asp Thr Arg Arg His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser 580 585 590 Asp Gly Ala Thr Val Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly 595 600 605 Gly Gin Ala Gin Lys Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg 610 615 620 Tyr Gin Leu Ala Giu Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val 625 630 635 640 Ile Leu Asp Glu Ala Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gin 645 650 655 Thr Met Asn Val Phe His Ser Phe Gly Phe His Met Val Leu Ala Thr 660 665 670 Pro Leu Lys Leu Ile Gin Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile 675 680 685 Val Val Ser Tyr Thr Glu Lys Pro Asn Ala Gin Giy Ala Ile Gin Gly 690 695 700 Asn Ser Ser Phe Ser Arq Ile Giu Lys 705 710 <210> 313 <211> 2147 <c212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (2124) <223> FRXA02547 <400> 313 gct gcg cgg ctg aec gtg gat gag tat ccg gcg gcg aqg gaa gcg ctt 48 Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala Ala Arg Glu Ala Leu 1 5 10 gaa tct gca ggt cag agg aat gta gag gac cga acc cgt gcg gtt gat 96 Giu Ser Ala Gly Gin Arg Asn Val Giu Asp Arg Thr Arg Ala Val Asp 25 gag ttc aaa gcg gcg gat caa gag ctg tct tct ttg agt aaa ggc agc 144 Giu Phe Lys Ala Ala Asp Gin Glu Leu Ser Ser Leu Ser Lys Gly Ser 40 agt aat att gag tac cgt ttg ctg cag gtg cgg gaa aat ttg tgt cag 192 Ser Asn Ile Giu Tyr Arg Leu Leu Gin Val Arg Glu Asn Leu Cys Gin 55 gat ttg ggc gtg agc ccg cgg gat atg ccc ttt gcc ggt gag ctg att 240 Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe Ala Gly Glu Leu Ile 70 75 gat ccg aat aat Asp Pro Asri Asn gog Ala gaa tgg gaa ccc Glu Trp Glu Pro gtg cag cgc att Val Gin Arg Ile ttg ggt Leu Gly gt ttt gCt Gly Phe Ala cgg gat tgg Arg Asp Trp 115 gaa atg ttg gtt Glu Met Leu Val Oct Pro 105 cat ggg ttg ttg His Gly Leu Leu cca cgg gtt Pro Arg Val 110 aaa ttc aac Lys Phe Asn gta aat gcc aaa Val Asn Ala Lys ttg gca gcg ctg Leu Ala Ala Leu ct g Leu 125 ggc gtg Gly Val 130 gtg aca acg ggg Val Thr Thr Gly gag Giu 135 tac aaa acc tcg Tyr Lys Thr Ser ttt cog gog gat Phe Pro Ala Asp t co Ser 145 ctg atc cga aaa Leu Ile Arg Lys gat gtt gtg gag Asp Val Val Giu tcg Se r 155 ccg ttt cgc gat Pro Phe Arg Asp qta aat caa gaa Val Asn Gin Giu t ta Leu 165 ggc sag cgt ttt Gly Lys Arg Phe att cgg tgo gtg Ile Arg Cys Val cgc act Arg Thr 175 cct gag ga Pro Glu Glu ttg ggt gtg Leu Gly Val 195 tog gog ctg ggg Ser Ala Leu Gly cgc gat cag ggc Arg Asp Gin Gly gtg acc stt Val Thr Ile 190 scg acg ogt Thr Thr Arg 576 624 oga aaa ttt gcg Arg Lys Phe Ala cag Gin 200 cag aca ggc gat Gin Thr Gly Asp cog Pro 205 tgg gaa Trp Giu 210 aaa gat gat ogc Lys Asp Asp Arg sag ctg ggg gat Lys Leu Gly Asp tcc acs tao ogt Ser Thr Tyr Arg t tg Leu 225 ggt tcc soc ast Gly Ser Thr Asn gat Asp 230 900 aag gtg gaa Ala Lys Val Glu acg Thr 235 ctt cgg gaa sc Leu Arg Giu Thr as gct ggc aa Lys Ala Gly Lys gtt gtg cag gos Val Val Gin Ala gat aat cgc stt Asp Asn Arg Ile got qos Ala Ala 255 aac cgc got Asn Arg Ala gaa att ttg Glu Ile Leu 275 gag Giu 260 ctg ogg gas ott Leu Arg Glu Leu gaa Giu 265 ogg cag tat caa Arg Gin Tyr Gln got tog cas Ala Ser Gin 270 toa goc gao Ser Ala Asp 816 864 ass gtg tog tgg Lys Vai Ser Trp oag att gat gtg Gin Ile Asp Val gog gog Ala Ala 290 att got gag ctg Ile Ala Giu Leu oga ttg otg gaa Arg Leu Leu Glu gag Glu 300 otg aso aac aot Leu Asn Asn Thr o oa Pro 305 gag gco aoo gag Glu Ala Thr Giu ott Leu 310 too gog ogg cat Ser Ala Arg His geg gcg aag cag Ala Ala Lys Gin Cc gCg agcj gtt Leu Ala Arc) Val tet Ser 325 gac ttg ctt gtc Asp Leu Leu Val get cag agt gag Ala Gin Ser Giu gaa ace Glu Thr 335 1008 k 4gtg gcg teqj fl Val Ala Ser ~tgaa age; ctg C] Glu Ser Leu 355 aac ctg aaa cge Asn Leu Lys Arg gaa act gaa ttg Giu Thr Giu Leu aaa cgg ctc Lys Arg Leu 350 egg gaa gtg Arg Glu Val 1056 1104 ccg gtt gcg gag Pro Val Ala Glu tct gaa gaa ate Ser Glu Giu Ile gag aaa Glu Lys 370 cta ttt ctt gce Leu Phe Leu Ala ace cgc cgg gtt Thr Arg Arg Val cac His 380 gcc gcc aac gtg Ala Ala Asn Val gag cacj ace att Glu Gin Thir Ile gCg Al a 390 ctg cgc gag gat Leu Arg Giu Asp ctg Le u 395 gac aaa caa atc Asp Lys Gin Ile ga t Asp 400 1152 1200 1248 1296 gcc aat gag gea Ala Asn Giu Ala ctt cga egt tgt Leu Arg Arg Cys aac caa att gtt Asn Gin Ile Val ggc att Gly Ile 415 ttg cgc agc Leu Arg Ser att gaa aeg tgg Ile Giu Thr Trp gcg aac cge get Ala Asn Arg Ala gac tta caa Asp Leu Gin 430 ggc gag ctt Gly Giu Leu gcc gaa ect gag ttt gtt ggt Ala Giu Pro Giu Phe Val Gly gag Gi u 440 gcc ate aac cgc Ala Ile Asn Arg ctc' Leu 445 cgc age Arg Ser 450 gat egt ttq gca Asp Arg Leu Ala gaa Giu 455 ttc acg gcc aaa Phe Thr Ala Lys eta ggg ctc atg Leu Gly Leu Met gag atg tcc ace Glu Met Ser Thr aac etc ggc caa Asn Leu Gly Gin atc Ile 475 teg cgg cgt eta Ser Arg Arg Leu egt Arg 480 1344 1392 1440 1488 1536 1584 gat gcg cgc: egg Asp Ala Arcj Arg gaa Giu 485 ate gag gag cgc Ile Giu Giu Arg atc Ile 490 gag ccg ate aac Glu Pro Ile Asn gee tce Ala Ser 495 ttg gcg eaq Leu Ala Gin Cgt gat caa Arg Asp Gin 515 gaa ttc aac gaa Giu The Asn Glu ggt Gly 505 cgc ttc etg eac Arg Phe Leu His ate: gac ate Ile Asp Ile 510 aaa ett gat Lys Leu Asp agt ggt ceg att Ser Gly Pro Ile agg gaa tte eag Arg Giu Phe Gin eag Gin 525 gee get Ala Ala 530 acc: age ggt gac Thr Ser Gly Asp etg Le u 535 gga ace agt ace Gly Thr Ser Thr gag Giu 540 aaa eaa gee tte Lys Gin Ala Phe 1632 1680 cgt tat: geg ctg Arg Tyr Ala Leu get gaa ate att Ala Gu Ile Ile aaa etc gee tee Lys Leu Ala Ser gac tee; gee, gac gee ege tgg ege aac ace gtt eta gae ace ege cge 72 1728 Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val Leu Asp Thr Arg Arq 565 570 575 cac gtt cgCo ttc atc ggc ctc gag cgc gat too gac gqc gca acc qtc 1776 His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser Asp Gly Ala Thr Val 580 585 590 aao aco tac gtc gac tcc gca tca ctt tca ggc gga caa gcc cag aag 1824 Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly Gly Gin Ala Gin Lys 595 600 605 otq gtg ttt ttc tgc ctc gcc gct gcc ttg cgc tac cag cta qcc gaa 1872 Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg Tyr Gin Leu Ala Glu 610 615 620 ccc ggc gocc cat tat ccc acc tao goc acc gtc att ctg gac gaa gco 1920 Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val Ile Leu Asp Giu Ala 625 630 635 640 ttc gac cgc gcc gao ccc gco ttc acc cgc caa aoc atg aac gto ttc 1968 Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gin Thr Met Asn Val Phe 645 650 655 cac ago tto ggc tto cac atg gtg ctc gcg acc cqg ctq aaa ctt atc 2016 His Ser Phe Gly Phe His Met .Val Leu Ala Thr Pro Leu Lys Leu Ile 660 665 670 caa aco cto ggc gat tat gto ggc too aco ato gtg gto ago tao acc 2064 Gin Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile Val Val Ser Tyr Thr 675 680 685 gaa aaa ooa aao goo oag ggo goa att cag ggo aat too agt tto tot 2112 Giu Lys Pro Asn Ala Gin Gly Ala Ile Gin Gly Asn Ser Ser Phe Ser 690 695 700 agg ato gag aaa taaoatgooa ttgtttatog aog 2147 Arg Ile Glu Lys 705 <210> 314 <211> 708 (212> PRT <213> Corynebacterium glutaniou <400> 314 Ala Ala Arc; Leu Thr Val Asp Glu Tyr Pro Ala Ala Arq Giu Ala Leu 1 5 10 Glu Ser Ala Gly Gln Arg Asn Val Glu Asp Arg Thr Arg Ala Val Asp 25 Giu Phe Lys Ala Ala Asp Gin Glu Leu Ser Ser Leu Ser Lys Gly Ser 40 Ser Asn Ile Glu Tyr Arg Leu Leu Gin Val Arg Glu Asn Leu Cys Gin 55 Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe Ala Gly Glu Leu Ile 70 '75 Asp Pro Asn Asn Ala Giu Trp Giu Pro Val Val Gin Arg Ile Leu Gly 90 Gly Phe Ala Ala Giu Met Leu Val Pro His Gly Leu Leu Pro Arg Val 100 105 110 Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala Leu Leu Lys Phe Asn 115 120 125 Gly Val Val. Thr Thr Gly Glu Tyr Lys Thr Ser Arg Phe Pro Ala Asp 130 135 140 Ser Leu Ile Arg Lys Val Asp Val Val Glu Ser Pro Phe Arg Asp Trp 145 150 155 160 Val Asn Gin Glu Leu Gly Lys Arg Phe Asn Ile Arg Cys Val Arg Thr 165 170 175 Pro Glu Giu Leu Ser Ala Leu Gly Pro Arg Asp Gin Gly Val Thr Ile 180 185 190 Leu Gly Val. Arg Lys Phe Ala Gin Gin Thr Gly Asp Pro Thr Thr Arg 195 200 205 Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp Arg Ser Thr Tyr Arg 210 215 220 Leu Gly Ser Thr Asn Asp Ala Lys Val Giu Thr Leu Arg Glu Thr Val 225 230 235 240 Lys Ala Gly Lys Ala Val Val Gin Ala Ala Asp Asn Arg Ile Ala Ala 245 250 255 Asn Arg Ala Giu Leu Arg Giu Leu Glu Arg Gin Tyr Gin Ala Ser Gin 260 265 270 Giu Ile Leu Lys Val Ser Trp Ala Gin Ile Asp Val Giu Ser Ala Asp 275 280 285 Ala Ala Ile Ala Giu Leu Asp Arg Leu Leu Glu Giu Leu Asn Asn Thr 290 295 300 Pro Giu Ala Thr Giu Leu Ser Ala Arg His Glu Ala Ala Lys Gin Thr 305 310 315 320 Leu Ala Arcj Val Ser Asp Leu Leu Val Ala Ala Gin Ser Glu Glu Thr 325 330 335 Val Ala Sei: Met Asn Leu Lys Arg Ala Glu Thr Giu Leu Lys Arg Leu 340 345 350 Giu Ser Leti Pro Val Ala Glu Val Ser Giu Giu Ile Ala Arg Giu Val 355 360 365 Giu Lys Leu Phe Leu Ala Asn Thr Arg Arg Vai His Ala Ala Asn Val 370 375 380 Asp Giu Gin Thr Ile Ala Leu Arg Glu Asp Leu Asp Lys Gin Ile Asp 385 390 395 400 Ala Asn Giu Ala Glu Leu Arg Arg Cys Giu Asn Gin Ile Val Gly Ile Leu Arg Ser Ala Glu Pro 435 Arg Ser Asp 450 Asn Glu Met 465 Asp Ala Arg Leu Ala Gin Arg Asp Gin 515 Ala Ala Thr 530 Ala Arg Tyr 545 Asp Ser Ala His Val Arg Asn Thr Tyr 595 Leu Val Phe 610 Pro Gly Ala 625 Phe Asp Arq His Ser Phe Gin Thr LeUl 675 Glu Lys Pro 690 Arg Ilie Glu 705 <210> 315 Tyr 420 Glu Arg Se r Arg Se r 500 Ser Se r Al a Asp Phe 580 Val1 Phe His Al a Gly 660 Gi y As n Lys Glu Val1 Ala Arg 470 Ile Phe Pro Asp Ile 550 Arg Gi y Ser Leu Pro 630 Pro His Tyr Gin Thr Gly Glu 455 As n Glu Asn Ile Leu 535 Ala Trp Leu Ala Ala 615 Thr Ala Met Val1 Gly 695 Trp Glu 440 Phe Leu Glu Giu Val1 520 Gly Giu Arg Giu Ser 600 Ala T yr Phe Val Gly 680 Ala Pro 425 Al a Thr Gi y Arg Gly 505 Ar g Th r Ile As n Arg 585 Le u Ala Al a Thr Le u 665 Ser Ile 410 Ala Ile Al a Gin Ile 490 Arg Glu Ser Ile Thr 570 Asp Ser Leu Thr Arg 650 Aia Thr Gin Asn Arg Ala Asp Leu Gin 430 Asn Lys Ile 475 Giu Phe Ph e Thr Ser 555 Val1 Ser Gly Arg Val1 635 Gin Thr Ile Gly Arg Phe 460 Ser Pro Le u Gin Glu 540 Lys Leu Asp Gly Tyr 620 Ile Thr Pro ValI As n 700 Leu 445 Le u Arg Ile His Gin 525 Lys Leu Asp Gly Gin 605 Gin Leu Met Leu Val1 685 Ser Gi y Gi y Arg As n Ile 510 Lys Gin Al a Thr Ala 590 Ala Leu Asp As n Lys 670 Se r Ser Giu Leu Leu Al a 495 Asp Leu Ala Ser Arg 575 Thr Gin Ala Giu ValI 655 Leu Tyr Phe Le u Met Arg 480 Se r Ile Asp Phe His 560 Arg Val1 Lys Glu Al a 640 Phe Ile Th r Se r <211> <212>' <213> <220> <221> <2 22> <223> 1152 DNA Corynebacterium glutamicum CDS (101)..(1129) RXN02571 <400> 315 tggaoagqcc ggggcogogt acggtgttgg ttgaggtggt attgtcgotg gttgttgocg cttttggcag tcgggatggc ggaggggcgc gtoqaaaaqo gtg gtg gct cta act ii. Val Val Ala Leu Thr caa atc qtc gga Gin Ile Val Gly ooq Pro tc ggC tcC qg Ser Gly Ser Gly aog cgg gaa ttg Thr Arg Glu Leu gaa aaa Giu Lys cgc tac ogg Arg Tyr Arg gcg cat ato Ala His Ile aog ccc gga gcq Thr Pro Gly Ala atg ctg ace gcc Met Len Thr Ala gac ccg cgc Asp Pro Arg ctg goc ttt Leu Ala Phe acc tao ctg cgc: Thr Tyr Leu Arg aca gtc gcc gag Thr Val Ala Giu gag Giu qqg ctg Gly Len gaa caa ogc ggc Giu Gln Arg Gly atc Ile gta ccc geg cag Val Pro Ala Gin tgg gag ogc gto Trp Gin Arg Val cga Arg aac ato ggg oto Asn Ile Gly Leu ctc gag aat otg Leu Gin Asn Leu ct a Leu gao cgc gca ccc Asp Arg Ala Pro oaa ctt tcc ggc Gin Leu Ser Giy ggg Gi y caa aca cgg cgg Gin Thr Arg Arg gog atc ggo: aco Ala Ile Gly Thr gto gcc Val Ala 100 ate tta gag Ile Leu Gin gat acc too Asp Thr Ser 120 oca acg atg ott Pro Thr Met Leu gao gac 000 cto Asp Asp Pro Leu too ggt ctt Ser Giy Leu 115 tca tat gag Ser Tyr Giu 451 499 tog oga goo oaa Ser Arg Ala Gin ato aoa atg ttg Ile Thr Met Leu gaa Giu 130 ggo gat Gly Asp 135 gtc ato gte got Val Ile Val Ala gog Ala 140 oac aag ogg tgg His Lys Arg Trp gao gog ccg act Asp Ala Pro Thr gtg Val 150 tao tta ggg gat Tyr Len Gly Asp gag gag otg too Gin Glu Leu Ser otg Leu 160 oot gog ogg gtg Pro Ala Arg Val 547 595 643 ttt too ggt oca Phe Ser Gly Pro tog Se r 170 oga acg ttt tca Arg Thr Phe Ser att aca gga aoo: Ile Thr Gly Thr ogo gga Arg Gly 180 oaa caa ogo cga ogc tgg tgg oaa tto aao gaa too caa ooa oag ttt Gin Gin Arg Arg Arg Trp Trp Gin Phe Asn Giu Ser Gin Pro Gin Phe 185 190 195 cag Gin tt g Leu gcc Al a 230 gtc Val1 ga a Giu gac Asp qac Asp gcg Ala 310 gaa Glu atc Ile c ag Gin 215 aa t Asn att Ile cat His gca Al a gt c Val 295 ga t Asp acc Thr ggc ccc Giy Pro 200 ggt: ccc Gly Pro gaa ccc Glu Pro gac tcc Asp Ser ccg ctg Pro Leu 265 gCC ctg Ala Leu 280 ggc ctt Gly Leu ttc tta Phe Leu ttc gtg Phe Val ct g Le u aat As n 9gc Gi y act Th r 250 ga t Asp 99jt Gly gat Asp ggg Gl y gca ga t Asp ggt Gi y act Thr 235 gt t Val1 tta Leu aa t As n gt c Val1 aat As n 315 gag att Ile tca Ser 220 gaa Glu gct Ala t cg Ser aac Asn ggc Gly 300 ggg Gly gta act Thr 205 ggg Gly ttg Leu aat Asn caa Gin CCg Pro 285 gg t Gly gga Gly gct gtt Val1 aag Lys atg Met tgg Trp cgc Arg 270 gaa Giu cga Arg gcg Ala gaa gca Al a aca Thr ca a Gin 240 cca Pro ct c Leu ttg Le u gcc Ala atc Ile 320 gcg Al a gg t Gly ctc Leu 225 aac As n ggc Gly cgc Arg ct t Leu atc Ile 305 ctg Le u ata Ile ctg Le u ggt Gly ga t Asp agt Ser 260 caa Gin gaa Glu cgc Arg cat His gaa Glu 340 tgg Trp ct t Le u caa Gin 245 ga a Gi u tgc Cys ccc Pro ttt Ph e gat Asp 325 atg Met 739 787 835 883 931 979 1027 1075 1123 1152 Ala Glu Val Ala Glu qgg ctc Gly Leu tagtttctt tggaccaaac cac <210> 316 <211> 343 <212> PRT <213> Corynebacterium glutanicum <400> 316 Val Val Aia Leu Thr Gin Ile Val Gly Pro Ser Giy Ser Gly Leu Thr 1 5 10 Arg Glu Leu Glu Lys Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu 25 Thr Ala Asp Pro Arg Ala His Ile Thr Tyr Leu Arq Ala Thr Val Ala 40 Glu Glu Leu Ala Phe Gly Leu Glu Gln Arq Gly Ile Val Pro Ala Gln 55 Met Trp, Giu Arg Val Arg Asn Ile Gly Leu Gly Leu Giu Asn Leu Leu 75 Asp Ile Pro Leu Le u 145 Pro Thr Ser Gly Leu 225 As n Gly Arg Le u Ile 305 Le u Ile Arg Gly Leu Giu 130 Asp Ala Gly Gin Gin 210 Leu Pro Ser Leu Ala 290 His Thr Val Al a Thr Se r 115 Ser Al a Ar g Thr Pro 195 Val1 Arg Ser Asn Ala 275 Asp Gin Cys Lys Pro Val1 100 Gly Tyr Pro Val1 Arg 180 Gin Le u Gly Asp Ser 260 Gin Glu Arg His Giu 340 Al a Al a Le u Glu Thr Gl u 165 Gly Phe Trp Leu Gin 245 Glu Cys Pro Phe Asp 325 Met Gin Ile Asp Gly Val1 150 Phe Gin Gin Leu Al a 230 Val Glu Asp Asp Ala 310 Glu Gly Leu Le u Thr Asp 135 Tyr Ser Gin Ile Gin 215 As n Ile His Al a Val 295 Asp Thr Leu Ser Giu Ser 120 Val1 Leu Gly Arg Gly 200 Gly Glu Asp Pro Ala 280 Gly Phe Phe Gly Ala 105 Ser Ile Gi y Pro Arq 185 Pro Pro Pro Ser Leu 265 Leu Le u Leu Val1 Gly 90 Pro Arg ValI Asp Ser 170 Arg Leu Asn Gly Thr 250 Asp Gly Asp Gi y Ala 330 Gin Thr Ala Al a Leu 155 Arg Trp Asp Gly Thr 235 Val Leu As n Val1 As n 315 Giu Thr Met Gin Ala 140 Giu Thr T rp Ile Ser 220 Giu Ala Ser Asn Gly 300 Gly Val Arg Leu 110 Ile Lys Le u Ser Phe 190 Val1 Lys Met Trp Arg 270 Glu Arg Ala Glu Leu Asp Thr Arg Ser Ala 175 Asn Ser Ser Leu ValI 255 Giu Val1 As n Leu Tyr 335 <210> 317 <211> 1152 <212> DNA <213> Corynebacterium glutamicum (220> <221> <222> <223> C DS FRXA02571 <400> 317 tggacagqcc ggggccgcgt acggtgttgg ttgaggtggt attqtcgctg qttgttgccg cttttggcag tcgggatggc ggaggggcgc gtcgaaaagc gtg gtg gct cta act 11! Val Val Ala Leu Thr caa atc gtc gga Gin Ile Val Gly tcc ggc tcc ggq Ser GJly Ser Gly acg cgq gaa ttg Thr Arg Giu Leu gaa aaa Glu Lys cgc tac cgg Arg Tyr Arg gcg cat atc Ala His Ile ga a Glu acg ccc gga gcg Thr Pro Gly Ala gtg Val1 30 atg ctg acc gcc Met Leu Thr Ala gac ccg cgc Asp Pro Arg ctg gcc ttt Leu Ala Phe acc tac ctg cgc Thr Tyr Leu Arg aca gtc goc gag Thr Val Ala Glu g ag Glu ggg ctg Gly Leu gaa caa ogc ggc Glu Gin Arg Gly gta ccc gcg cag Val Pro Ala Gin tgg gag cgc gtc Trp Giu Arg Val cga Arg aac atc ggg ctc Asn Ile Gly Leu ggc Gly 75 cto gag aat ctg Leu Giu Asn Leu ot a Leu gao cgc qca ccc Asp Arg Ala Pro caa ctt tcc ggc Gin Leu Ser Gly caa aca cgg cgg Gin Thr Arg Arg gcg atc ggo acc Ala Ile Gly Thr gtC gc Val Ala 100 atc tta gag Ile Leu Glu 9gg Al a 105 cca acg atg ctt Pro Thr Met Leu gac gac ccc ctc Asp Asp Pro Leu tcc ggt ctt Ser Gly Leu 115 tca tat gag Ser Tyr Glu gat aco Asp Thr qgc gat Gly Asp 135 tcg oga gcc caa Ser Arg Ala Gin ctc Leu 125 ato aca atg ttg Ile Thr Met Leu gaa Giu 130 qto atc qtc qct Val Ile Val Ala cac aaq cgg tgg His Lys Arg Trp gac gcg cog act Asp Ala Pro Thr gtg Val1 150 tac tta ggg gat Tyr Leu Gly Asp ttg Leu 155 gag gag ctg tcc Glu Giu Leu Ser ctg Leu 160 cot gog cgg gtg Pro Ala Arg Val ga a Glu 165 ttt tcc ggt oca Phe Ser Gly Pro cga acg ttt toa Arg Thr Phe Ser att aca gga acc Ile Thr Gly Thr ogc gga Arg Gly 180 caa caa cgo Gin Gin Arg cga Ar g 185 cqc tgg tgg caa Arq Trp Trp Gin aac qaa tcc caa Asn Glu Ser Gin cca cag ttt Pro Gin Phe 195 cag atc ggc ccc ctg gat att act gtt tot gca ggt caa gtg Otg tgg Gin Ile Gly Pro Leu Asp Ile Thr Val Ser Ala Gly Gin Val Leu Trp 200 205 210 ttg cag ggt ccc aat ggt tca ggg aag tcc aca ctc ctg cgt ggt ctt 787 Leu Gin Gly Pro Asn Gly Ser Giy Lys Ser Thr Leu Leu Arg Gly Leu 215 220 225 qcc aat qaa ccc ggc act qaa ttg atg ctq caa aac cct agc gat caa 835 Ala Asn Giu Pro Gly Thr Glu Leu Met Leu Gin Asn Pro Ser Asp Gin 230 235 240 245 gtc att gac tcc act gtt gct aat tgg gtg cca ggc agt aac agt gaa 883 Val Ile Asp Ser Thr Val Ala Asn Trp Vai Pro Giy Ser Asn Ser Giu 250 255 260 gaa cat ccg ctg qat tta tcg caa cgc gaa ctc cgc ctt gcc caa tgc 931 Giu His Pro Leu Asp Leu Ser Gin Arg Giu Leu Arg Leu Ala Gin Cys 265 270 275 gac gca gcc ctg ggt aat aac ccg gaa gtt ttg ctt gct gat gaa ccc 979 Asp Ala Ala Leu Gly Asn Asn Pro Giu Val Leu Leu Ala Asp Glu Pro 280 285 290 gac gtc ggc ctt gat qtc gqc ggt cga aac gcc atc cac cag cgc ttt 1027 Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala Ile His Gin Arg Phe 295 300 305 gcg gat ttc tta ggg aat ggg gga gcg ctg atc ctg acc tgc cat gat 1075 Ala Asp Phe Leu Giy Asn Gly Gly Ala Leu Ile'Leu Thr Cys His Asp 310 315 320 325 gaa acc ttc gtg gca gag gta gct gaa tac gcg ata gtg aag gaa atg 1123 Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala Ile Val Lys Glu Met 330 335 340 ggg ctc taggtttctt tggaccaaac cac 1152 Gly Leu '210> 318 <211> 343 '212> PRT (213> Corynebacterium giutamicum <400> 318 Val Val Ala Leu Thr Gin Ile Val Gly Pro Ser Gly Ser Gly Leu Thr 1 5 10 Arg Giu Leu Giu Lys Arg Tyr Arg Giu Thr Pro Gly Ala Vai Met Leu 25 Thr Ala Asp Pro Arg Ala His Ile Thr Tyr Leu Arq Ala Thr Val Ala 40 Glu Giu Leu Ala Phe Gly Leu Giu Gin Arg Gly Ile Val Pro Ala Gin 55 Met Trp Giu Arg Val Arg Asn Ile Gly Leu Gly Leu Giu Asn Leu Leu 70 75 Asp Arg Ala. Pro Ala Gin Leu Ser Gly Gly Gin Thr Arg Arg Leu Ala 90 Ile Pro Leu Leu 145 Pro Thr Ser Gly Leu 225 Asn Gly Arg Leu Ile 305 Leu Ile Gly Leu Giu 130 Asp Ala Gly Gin Gin 210 Leu Pro Ser Le u Ala 290 His Thr Val1 T hr Ser 115 Ser Ala Arg Thr Pro 195 Val1 Arg Ser Asn Al a 275 Asp Gin Cys Lys Val1 100 Gi y Tyr Pro Val1 Arg 180 Gin Le u Gly Asp Ser 260 Gin Giu Arg His Giu 340 Ala Le u Glu Thr Giu 165 Gly Phe Trp Leu Gin 245 Giu Cys Pro Phe Asp 325 Met Gi u Se r 120 Val Leu Giy Arg Gly 200 Gly Glu Asp Pro Ala 280 Gi y Phe Phe Pro Arg ValI Asp Ser 170 Arq Leu As n Gly Thr 250 Asp Gly Asp Gly Al a 330 Thr Ala Al a Leu 155 Arg T rp Asp Gly Thr 235 Val1 Leu As a Val1 As n 315 Glu Met Gin Al a 140 Gi u Th r Trp Ile Ser 220 Glu Ala Ser As n Gly 300 Gly Val1 Leu Leu 125 His Glu Phe Gin Thr 205 Gly Leu As n Gin Pro 285 Gly Gly Ala Asp Met Trp Le u 160 Ile Glu Ala Thr Gln 240 Pro Le u Le u Ala I le 320 Ala <210> 319 <211> 1746 <212> DNA <213> Corynebacterium qiutamicun <22 0> <221> CDS <222> (1723) <223> RXN02074 <400> 319 cgggggaagg cogtgtcqca, tgctogggct agccttggat tttaaagtct gggotttaag tgcagaaagg ttgtggattg otcaagaaga. attcgactgg atg cgc tcc ctg ctt 11. Met Arg Ser Leu Leu cgt gat atc cot. Arg Asp Ile Pro gcg Ala gtg ggt tgg cta atc acc gcg acg att Val Gly Trp Leu Ile Thr Ala Thr Ile 15 gtt gtg Val Val cqc acg cto Arg Thr Leu gao gtc coo Asp Val Pro gtt gcg otg gtC Val Ala Leu Val atc Ile gtt ggg atc ggc Val Gly Ile Gly ttg ott. atc Leu Leu Ile gtt ctg gca Val Leu Ala tog ccc gct. cat Ser Pro Ala His goc atg ttg tgg Ala Met Leu Trp ggt gcc Giy Ala acg gca gca qot Thr Ala Ala Ala otg ctg tgo gcg Leu Leu Cys Ala gaa Glu gog gtg ctc coo Ala Val Leu Pro cgt att cqt gca. Arg Ilie Arg Ala cga Arg gtt gaa cga too Val Giu Arq Ser ogg cqg cag ttg Arg Arg Gin Leu got Al a got aaa aat otg Ala Lys Asn Leu gag Gl u otg aat too Leu Asn Ser aqt tcg Ser Ser 95 toa gat gat goo Ser Asp Asp Ala cag ttg Gin Leu 100 atc aca ctg Ile Thr Leu atg ttt otg Met Phe Leu 120 act gaa gcc acc Thr Glu Ala Thr tca Ser 110 aaa gca tcC act Lys Ala Ser Thr tac aca gtg Tyr Thr Val 115 ctg aca. qtt Leu Thr Val ggg oct, tao ttt Gly Pro Tyr Phe gta ttt ttg gc Val Phe Leu Ala ooa Pro 130 att gco Ile Ala 135 gtt gto ggc gog Val Val Gly Ala att too tgg cog Ile Ser Trp Pro att Ile 145 gog gqq ata otg Ala Gly Ile Leu tgc Cys 150 ctc ggg ttg tgC Leu Gly Leu Cys gtg Val1 155 ata. cot ttc gtt Ile Pro Phe Val tot tgg goa oag Ser Trp Ala Gin ogo Arg 165 atg ttg aaa ggc Met Leu Lys Gly got Al a 170 ggo gcg gga tao Gly Ala Gly Tyr cga gca tot ggg Arg Ala Ser Gly cag ttg Gin Leu 180 gca ggc gtg Ala Gly Val otg aat gc Leu Asn Ala 200 ttg gaa tog gtg Leu Glu Ser Val ogo Arg 190 aca ota, ggo aco Thr Leu Gly Thr aog atg atg Thr Met Met 195 cgo gca gag Arg Ala Glu 691 739 gct ggg cag ogo Ala Gly Gin Arg cag ato ato aca Gin Ile Ile Thr aat atg cgc tcc caa gtg atg tca ttg ctg tac cga aat cag ttg atg Asn Met 215 Arcj Ser Gin Vai Met Ser Leu Leu Tyr Arg Asn Gin Leu Met att Ile 230 ctg gtcl aco gao Leu Val. Thr Asp ggo Gly 235 gtg ttt gga gtt Val Phe Gly Vai gcc Al a 240 aco aca atq git Thr Thr Met Val gog gtg ttt gcc Ala Vai Phe Ala gga qga ttc ttt Giy Gly Phe Phe ggc tot ott act Gly Ser Leu Thr oto ggo Leu Gly 260 oaa got qta Gin Ala Val aac ogc atcJ Asn Arg Met 280 goa Ala 265 oto gta ttg otg Leu Val Leu Leu go o Ala 270 agg otg ott att Arg Leu Leu Ile gat ooc ato Asp Pro Ile 275 aaa 000 tog Lys Pro Ser ggt cgo aog ttt Gly Arg Thr Phe aco ggo atg goa Thr Giy Met Ala otg ato Leu Ile 295 goo att gaa aaa Aia Ile Giu Lys goo Ala 300 oto gog aoa aco Leu Ala Thr Thr ttt Ph e 305 aot gat cag oca Thr Asp Gin Pro aot Thr 310 oaa cac; gga oag Gin Gin Giy Gin oao gat ggg gat His Asp Gly Asp ctg Le u 320 gtg gto aao aac Vai Val Asn Asn 1027 1075 1123 aag ato goo ogo Lys Ile Aia Arg oao agg gao att His Arg Asp Ile oao ggt ato tot His Gly Ile Ser ttc ago Phe Ser 340 att 000 ogo Ile Pro Arcj aaa too tot Lys Ser Ser 360 ggt Gly 345 too oao ato qg Ser His Ile Ala gta ggt 000 agt Val Gly Pro Ser ggo got ggt Gly Aia Gly 355 ttt gat ggt Phe Asp Giy 1171 1219 gtg gct ota gog Val Ala Leu Ala ttg Lebi 365 too gga ott tta Ser Gly Leu Leu gag Giu 370 gog att Ala Ile 375 too oto ggo ggo Ser Leu Gly Giy oao His 380 aao tgt gag atg Asn Cys Giu Met gat ott ogo gc Asp Leu Arg Ala 1267 1315 toa Ser 390 gto agt tto gtg Val Ser Phe Val 000 Pro 395 caa too cco acg Gin Ser Pro Thr ttt ago gga ago Phe Ser Gly Ser aaa ago aat ato gat ctg gog ogo aog ggt gtt gat tot gat Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val Asp Ser Asp oac ato His Ile 420 1363 oac goa gca His Ala Ala gaa aoc ggc Giu Thr Gly 440 tta ggo gaa gaa Leu Gly Glu Giu 000 gog gao oto Pro Ala Asp Leu aaa gto ggt Lys Vai Giy 435 att too att Ile Ser Ile 1411 1459 aaa gqt gto too Lys Gly Val Ser ggo Gly 445 ggo oaa goa goa Gly Gin Ala Ala ogo Arg .4 goc oga ggt tta gta aag aat got goc gtg att gtt oto gao gag gog Ala Arg Gly Leu Vai Lys Asn Ala Ala Val Ile Val Leu Asp Giu Ala 1507 455 460 acc gca caa ctc gac tac acc aac Thr Ala Gin Leu Asp Tyr Thr Asn 470 475 aaa tcc ctt gag tgc acg ttg gtt Lys Ser Leu Giu Cys Thr Leu Val 490 gcc ctc gat gca gac ttc atc att Ala Leu Asp Ala Asp Phe Ile Ile 505 atg atg gat aca ccc agc aac gtt Met Met Asp Thr Pro Ser Asn Val 520 525 aCC gct gtq atg gag gaa gaa caa Thr Ala Val Met Glu Glu Glu Gin 535 540 <210> 320 <211> 541 <212> PRT <213> Corynebacterium glutamicur 465 gcc cgc cag gtt cga cat ctt Ala Arg Gin Val Arg His Leu 480 gag atc acc cac cgc cca tca Giu Ilie Thr His Arg Pro Ser 495 500 gtt tta gag gat ggc caa ttg Val Leu Glu Asp Gly Gin Leu 510 515 tcc cag cac aat gcg ttt ttc Ser Gin His Asn Ala Phe Phe 530 tgatttcccg acttctccaa ttg 1555 1603 1651 1699 1746 <400> 320 Met Arg S 1 Ala Thr I. Ile Gly D Trp Trp Vi Glu Ala Vi Arg Arg G.' Asp Asp A: Ser Thr T, 1:. Ala Pro L( 130 Ile Ala G' 145 Ser Trp A: er Leu Leu Arg Asp Ile Pro Val Leu Le u Leu Leu Gin 100 Thr Thr Ile Gin Thr Val1 Al a 55 Arg Lys Thr Phe Al a 135 Leu Leu Val1 25 Ser Al a Arg Leu Ala 105 Gi y Val1 Leu Gly Ala Val1 Pro Al a Al a Giu Thr Pro Giy Cys Al a 170 Val1 Al a Al a Al a Arg 75 Le u Giu Tyr Al a Val1 155 Gly Gly Leu His Ala Val1 Asn Ala Phe Ala 140 Ile Ala Trp Val1 Ser Le u Glu Se r Th r Al a 125 Ile Pro Gi y Leu Ile Ala Leu Arg Ser Ser 110 Val1 Ser Phe Tyr Thr Gly Leu Ala Trp Ser Ala Leu Pro I le 160 Arg Ala Ser Gly Gin Leu Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu 180 185 190 Gly Thr Thr Met Met Leu Asn Ala Ala Gly Gin Arg Arg Gin Ile Ile 195 200 205 Thr Gin Arg Ala Glu Asn Met Arg Ser Gin Val Met Ser Leu Leu Tyr 210 215 220 Arg Asn Gin Leu Met Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala 225 230 235 240 Thr Thr Met Val Ala Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly 245 250 255 Ser Leu Thr Leu Gly Gin Ala Val Ala Leu Val Leu Leu Ala Arg Leu 260 265 270 Leu Ile Asp Pro Ile Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met 275 280 285 Ala Gly Lys Pro Ser Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr 290 295 300 Phe Thr Asp Gin Pro Thr Gin Gin Gly Gin Arg His Asp Gly Asp Leu 305 310 315 320 Val Val Asn Asn Leu Lys Ile Ala Arg Asp His Arg Asp Ile Val His 325 330 335 Gly Ile Ser Phe Ser Ile Pro Arg Gly Ser His Ile Ala Val Val Gly 340 345 350 Pro Ser Gly Ala Gly Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu 355 360 365 Leu Glu Phe Asp Gly Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met 370 375 380 Leu Asp Leu Arg Ala Ser Val Ser Phe Val Pro Gin Ser Pro Thr Leu 385 390 395 400 Phe Ser Gly Ser Ile Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val 405 410 415 Asp Ser Asp His Ile His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala 420 425 430 Asp Leu Lys Val Gly Glu Thr Gly Lys Gly Val Ser Gly Gly Gin Ala 435 440 445 Ala Arg Ile Ser Ile Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile 450 455 460 Val Leu Asp Glu Ala Thr Ala Gin Leu Asp Tyr Thr Asn Ala Arg Gin 465 470 475 480 Val Arg His Leu Ala Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr 485 490 495 His Arg Pro Ser Giu Ala Leu Asp Ala 500 505 Asp Gly Gin Leu Thr Met Met Asp Thr 515 520 Asp Phe Ile Pro Ser Asn Ile Val Leu Giu 510 Val Ser Gin His 525 Asn Ala Phe Phe Arg Thr Ala Val Met Giu Giu Giu Gin 530 535 540 <210> <211> <212> <213> <220> <221> <222> <223> 321 1746 DNA Corynebacterium GOS (1723) FRXA02074 giutamicum <400> 321 cgggggaagg ccgtgtcgca tgctcgggct agccttggat ctcaagaaga attcgactgg tttaaagtct gggctttaag tgcagaaagg ttgtggattg atg cgc tcc ctg Met Arg Ser Leu 1 cgt gat atc cct Arg Asp Ile Pro gtg ggt tgg cta Val Gly Trp Leu acc gog acg att Thr Ala Thr Ile gtt gtg Val Val cgc acg ctc Arg Thr Leu gac gtc ccc Asp Val Pro gt t Val gtt gcg ctg gtc Val Ala Leu Val gtt ggg atc qgc Val Gly Ile Gly ttq ctt atc Leu Leu Ile gtt ctg gca Val Leu Ala 211 259 tcg ccc gct cat Ser Pro Ala His tca Ser 45 gcc atg ttg tgg Ala Met Leu Trp tgg Trp ggt gcc Gly Ala acg gca gca gct Thr Ala Ala Ala ctg ctq tgc gcg Leu Leu Cys Ala gcg gtg ctc ccc Ala Val Leu Pro cgt att cqt gca Arg Ile Arg Ala cga Arg gtt gaa cga tcc Val Giu Arg Ser tgg Trp cgg cgg cag ttg Arg Arg Gin Leu 307 355 403 gct aaa aat ctg Ala Lys Asn Leu gag Giu ctg aat tcc agt Leu Asn Ser Ser tca gat gat gcc Ser Asp Asp Ala cag ttg Gin Leu 100 atc aca ctg Ile Thr Leu atg ttt ctg Met Phe Leu 120 act qaa gcc acc Thr Glu Ala Thr aaa gca tcc act Lys Ala Ser Thr tac aca gtg Tyr Thr Val 115 ctg aca gtt Leu Thr Val 451 499 ggg cct tac ttt Gly Pro Tyr Phe gca Ala 125 gta ttt ttg gcc Val Phe Leu Ala cca Pro 130 att gcc gtt qtc ggc gcg gct att tcc tgg ccg att gcg ggg ata ctg Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro Ile Ala Gly Ile Leu 140 145 tgc Cys 150 ctc ggg ttg tgc Leo Gly Leu Cys gtg Val1 155 ata cct ttc gtt Ile Pro Phe Val tct tgg gca cag Ser Trp Ala Gin cgc Arg 165 595 643 atg ttg aaa ggc Met Leu Lys Gly ggc gcg gga tac Gly Ala Gly Tyr ggg Gly 175 cga gca tct ggg Arg Ala Ser Gly cag ttg Gin Leu 180 gca ggc gtg Ala Gly Val ctg aat gcc Leo Asn Ala 200 ttg qaa tcg gtg Leu Glu Ser Val cgc Arg 190 aca cta qgc acc Thr Leu Gly Thr acg atg atg Thr Met Met 195 cgc gca gag Arg Ala Glu gct ggg cag cgc Ala Gly Gin Arg cag atc atc aca Gin Ile Ile Thr ca g Gin 210 aat atg Asn Met 215 cgqc tcc caa gtg Arg Ser Gin Val tca ttg ctg tac Ser Leo Leu Tyr aat cag ttg atg Asn Gin Leu Met ctg gtg acc gac Leo Val Thr Asp qgc Gi y 235 gtg ttt gga gtt Val Phe Gly Val gcc Al a 240 acc aca atg gtt Thr Thr Met Val gct Ala 245 qcg gtg ttt gCC Ala Vai Phe Ala gga gga ttc ttt Gly Gly Phe Phe ggc tct ctt act Gly Ser Leu Thr ctc ggc Leu Gly 260 caa gct gta Gin Ala Val aac cgc atq Asn Arg Met 280 gca Al a 265 ctc gta ttg ctg Leu Val Leu Leu qcc Al a 270 agg ctg ctt att Arg Leu Leu Ile gat ccc atc Asp Pro Ile 275 aaa ccc tcg Lys Pro Ser 931 979 ggt cgc acg ttt Gly Arg Thr Phe tac Tyr 285 acc ggc atg gca Thr Gly Met Ala ggc Gly 290 ctq atc Leu Ile 295 qcc: att gaa aaa Ala Ile Giu Lys qcc Ala 300 ctc gcg aca acc Leo Ala Thr Thr act gat cag cca Thr Asp Gin Pro act Thr 310 caa cag gga cag Gin Gin Gly Gin cgc Arg 315 cac gat ggg gat His Asp Gly Asp gtg gte aac aac Val Vai Asn Asn ttq Leo 325 1027 1075 1123 aag atc gcc cgc Lys Ile Ala Arg cac agg gac att His Arg Asp Ile gtg Val1 335 cac ggt ate tct His Gly Ile Ser ttc agc Phe Ser 340 att ccc cgc Ile Pro Arg aaa tcc tct Lys Ser Ser 360 tcc cac atc gcg Ser His Ile Ala gta ggt ccc agt Val Gly Pro Ser ggc get ggt Gly Ala Gly 355 ttt gat ggt Phe Asp Gly 1171 1219 gtg gct eta gcg Val Ala Leo Ala ttg Leu 365 tcc gga ctt tta Ser Gly Leu Leu gcg att Ala Ile 375 tcc- ctc ggc ggc Ser Leo Gly Gly aac tgt gag atg Asn Cys Glu Met tta Leu 385 gat ctt cgc gcc Asp Leo Arg Ala 1267 tca gtc aqt ttc gtg Ser Val Ser Phe Val ccc caa tcc ccc acq ctq ttt agc Pro Gin Ser Pro Thr Leu Phe Ser gga ago atc Gly Ser Ile 405 1315 aaa ago aat atc gat ctg gcg cgc Lys Ser Asn Ile Asp Leu Ala Arg 410 cac gca gca ctt tta ggc gaa gaa His Ala Ala Leu Leu Gly Glu Glu 425 gaa acc ggo aaa ggt gto tcc ggc Glu Thr Gly Lys Gly Val Ser Gly 440 445 gcc cqa ggt tta gta aag aat got Ala Arg Gly Leu Val Lys Asn Ala 455 .460 acc gca caa otc gao tac acc aac Thr Ala Gin Leu Asp Tyr Thr Asn 470 475 aaa tco ott gag tgc acg ttg gtt Lys Ser Leu Glu Cys Thr Leu Val 490 goo ctc gat. goa gac tto atc att Ala Leu Asp Ala Asp Phe Ile Ile 505 atg atg gat. aca ccc ago aac gtt Met Met Asp Thr Pro Ser Asn Vai 520 525 aoo got gtcj atg gag qaa gaa oaa Thr Ala Val. Met Giu Glu Giu Gin 535 540 <210> 322 <211> 541 <212> PRT <213> Corynebacterium glutamiut (400> 322 Met Arg Ser Leu Leu Arg Asp Ile 1 5 Ala Thr Ile Val Val Arg Thr Leu Ile Gly Leu Leu Ile Asp Vai Pro 40 Trp Trp Vai Leu Ala Gly Ala Thr 55 Giu Ala Val Leu Pro Gin Arg Ile acg Thr ot 0 Le u 430 gg o Gi y gc Al a gc Al a gag Gi u gt t Val1 510 tc Se r ggt Gly 415 000 Pro caa Gin gtg Val1 ogo Arg ato Ile 495 tta Leu ca g Gin gt t ValI gog Al a gca Ala at t Ile cag Gin 480 aco Th r gag Giu cac His gat tot Asp Ser gao oto Asp Leu goa ogo Ala Arg 450 gtt oto Val Leu 465 gtt oga Val Arg cac cgo His Arg gat ggo Asp Gly aat gog Asn Ala cac His 420 gto Val too Ser gag Giu ott Le u toa Se r 500 ttg Leu ttc Phe ato Ile ggt Gi y att Ile gcg Ala gco Ala 485 gaa Glu acc Thr og o Arg 1363 1411 1459 1507 1555 1603 1651 1699 tgatttooog acttctooaa ttg 1746 Pro Ala 10 Val Val 25 Ser Pro Ala Ala Arg Ala Val Gly Trp Leu Ile Thr Ala Leu Vai Ile Val Gly Ala His Ser Ala Met Leu Ala Ala Leu Leu Cys Ala Arg Val Glu Arg Ser Trp Arg Asp Ser Ala Ile 145 Ser Ala Gly Thr Arg 225 Thr Ser Leu Ala Phe 305 Val Gly Pro Leu Leu 385 Arg Asp Thr Pro 130 Ala Trp Ser Thr Gin 210 Asn Thr Leu Ile Gly 290 Thr Val Ile Ser Glu 370 Asp Gin Ala Tyr 115 Leu Gly Ala Gly Thr 195 Arg Gin Met Thr Asp 275 Lys Asp Asn Ser Gly 355 Phe Leu Leu Gin 100 Thr Thr Ile Gin Gin 180 Met Ala Leu Val Leu 260 Pro Pro Gin Asn Phe 340 Ala Asp Arg Ala Leu Val Val Leu Arg 165 Leu Met Glu Met Ala 245 Gly Ile Ser Pro Leu 325 Ser Gly Gly Ala 70 Ala Ile Met Ile Cys 150 Met Ala Leu Asn Ile 230 Ala Gin Asn Leu Thr 310 Lys Ile Lys Ala Ser 390 Lys Thr Phe Ala 135 Leu Leu Gly Asn Met 215 Leu Val Ala Arg Ile 295 Gin Ile Pro Ser Ile 375 Val Asn Leu Leu 120 Val Gly Lys Val Ala 200 Arg Val Phe Val Met 280 Ala Gin Ala Arg Ser 360 Ser Ser Leu Ala 105 Gly Val Leu Gly Phe 185 Ala Ser Thr Ala Ala 265 Gly Ile Gly Arg Gly 345 Val Leu Phe Glu 90 Thr Pro Gly Cys Ala 170 Leu Gly Gin Asp Ile 250 Leu Arg Glu Gin Asp 330 Ser Ala Gly Val 75 Leu Glu Tyr Ala Val 155 Gly Glu Gin Val Gly 235 Gly Val Thr Lys Arg 315 His His Leu Gly Pro 395 Asn Ala Phe Ala 140 Ile Ala Ser Arg Met 220 Val Gly Leu Phe Ala 300 His Arg Ile Ala His 380 Gin Ser Thr Ala 125 Ile Pro Gly Val Arg 205 Ser Phe Phe Leu Tyr 285 Leu Asp Asp Ala Leu 365 Asn Ser Ser Ser 110 Val Ser Phe Tyr Arg 190 Gin Leu Gly Phe Ala 270 Thr Ala Gly Ile Val 350 Ser Cys Pro Ser Lys Phe Trp Val Gly 175 Thr Ile Leu Val Ser 255 Arg Gly Thr Asp Val 335 Val Gly Glu Thr Ser Ala Leu Pro Ile 160 Arg Leu Ile Tyr Ala 240 Gly Leu Met Thr Leu 320 His Gly Leu Met Leu 400 Phe Ser Gly Ser Ile Lys Ser Asn Ile Asp Leu 405 410 Asp Ser Asp His Ile His Ala Ala Leu Leu Gly 420 425 Asp Leu Lys Val Gly Glu Thr Gly Lys Gly Val 435 440 Ala Arg Ile Ser Ile Ala Arg Gly Leu. Val Lys 450 455 Val Leu Asp Glu Ala Thr Ala Gin Leu Asp Tyr 465 470 475 Val Arg His Leu Ala Lys Ser Leu Glu Cys Thr 485 490 His Arg Pro Ser Glu Ala Leu Asp Ala Asp Phe 500 505 Asp Gly Gin Leu Thr Met Met Asp Thr Pro Ser 515 520 Asn Ala Phe Phe Arg Thr Ala Val Met Glu Glu 530 535 <210> 323 <211> 1527 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1504) <223> RXA02095 <400> 323 ctctcttggt cctctcccca cccattttta agtactcaag tactccccca acaggctcaa aaatactgaa aggctcacgc Arg Glu Gly 445 Ala Asn Val Ile Val1 525 Gin Thr Leu 430 Gi y Al a Al a Glu Val1 510 Ser too Ser ogo Arg t ca Ser ctt Leu aaa Lys cgC Arg acc Thr ctt Leu caa Gin ott Leu atc Ile acc Thr gc Aila tcc Ser gct Al a gg C Gly cot Pro gt g Val1 tta Leu 45 gcc Al a aaa Lys 15 t gg Trp gca Al a ga t Asp gca Ala cag Gin a cg Thr atc le acccttccaa cagaaaggat atg aaa act gag caa Met Lys Thr Giu Gin 1 cct gaa aag cca caa Pro Glu Lys Pro Gin cga Oct tgg ctc aco Arg Pro Trp Leu Thr ttq ttt gaa ctt aca Leu Phe Glu Leu Thr gcg cic gga aat acc Ala Leu Gly Asn Thr 115 163 211 259 307 gga Gly gat act tta ac Asp Thr Leu Thr act Thr gac ctg ctg gac Asp Leu Leu Asp ttc act ccg agt Phe Thr Pro Ser 355 4103 tta agc gtg ttg Leu Ser Val Leu agc gtc att gcc Ser Vai Ile Ala ct t Leu atc gtg ctt ctc Ile Val Leu Leu gcg ttg Ala Leu 100 ctt cgc tat. Leu Arg Tyr agc atg gg Ser Met Gly 120 gcc Ala 105 agt caa ttt gga Ser Gin Phe Gly cga tac acc gca Arg Tyr Thr Ala ggc aaq ctc Gly Lys Leu 115 cgc tca ttg Arg Ser Leu 451 4199 gta cag cat gat Val Gin His Asp cgg ctt aaa acg Arg Leu Lys Thr cag aac Gin Asn 135 ctc: gat ggg cca LeU Asp Gly Pro cag gac tct att. Gin Asp Ser Ile cgc Arg 145 aca gqc caa gta Thr Gly Gin Val agt cgcr tcc att Ser Arcj Ser Ile t cg Ser 155 gat atc aac atg Asp Ile Asn Met caa agc ctt gtg Gin Ser Leu Val atg ttg ccq atg Met Leu Pro Met atc gga aat gtg Ile Gly Asn Val gt c Vali 175 aag ctt gtg ctc Lys Leu Val Leu act ttg Thr Leu 180 gtg atc atql Val Ile Met ttg gtg cct Leu Vai Pro 200C ct 9 Leui 185 gct att tcc ccg Ala Ile Ser Pro ctg acc atc atc Leu Thr Ile Ile gct gca gtg Aia Ala Val 195 aaa gcg ctt. Lys Ala Leu ttg ctg ttg tgg Leu Leu Leu Trp gtg gcc tat tcg Val Ala Tyr Ser ttt gcg Phe Ala 215 tcc acg tgg tcg Ser Thr Trp Ser cag caa aag gct Gin Gin Lys Ala gcg Ala 225 gat ctg acc act Asp Leu Thr Thr gtg gaa gaa act Val Giu Giu Thr gt c Val1 235 acg ggt atc cgc Thr Gly Ile Arg gtg Val1 240 gtc aag gca ttt Val Lys Ala Phe caq gaa gac cgc Gin Giu Asp Arg acc gac aaa ttg Thr Asp Lys Leu ctc acc gca cgt Leu Thr Ala Arg gag tta Giu Leu 260 ttt gcc cag Phe Ala Gin atq gtt gag Met Val Giu 280 cg c Arg 265 atg cgc act gca Met Arg Thr Ala cgt Arg 270 ctg acg gca aag Leu Thr Ala Lys ttc atc ccc Phe Ile Pro 275 att. gtt ggc Ile Val Gly cag ctt ccg cag Gin Leu Pro Gin gct ttg gtg gtc Ala Leu Val Val aac As n 290 ggt ggc Gly Gly 295 tat ttg gcc atg Tyr Leu Ala Met ggt cac atc acg Giy His Ile Thr ggc acg ttt gtg Gly Thr Phe Val 1027 g cg Ala 310 ttt tot too tat Phe Ser Ser Tyr ct C Le u 315 act agc ttg tog Thr Ser Leu Ser gcg Al a 320 gtg got agg tcc Val Ala Arg Ser ot g Le u 325 1075 1123 tcg ggc atg ctc Ser Giy Met Leu ogo gtg cag ttg Arg Val Gin Leu ctg tot tct gtg Leu Ser Ser Val gag ogc Glu Arg 340 atc ttt gaa Ile Phe Giu ccc ctg tca Pro Leu Ser 360 att gat ott cag Ile Asp Leu Gin gaa cgc aco gat Giu Arg Thr Asp cot. gca cac Pro Aia His 355 aac aac gta Asn Asn Val 1171 1219 ott coo gao act Leu Pro Asp Thr 000 Pro 365 ctg ggt otg tog Leu Gly Leu Ser gat tto Asp Phe 375 ogt ggq att oto Arg Gly Ile Leu aac Asn 380 ggt ttt gag Ctg Giy Phe Giu Leu gtt cag goc ggt Val Gin Ala Gly gaa Giu 390 acc gtt gtg ttg Thr Val Val Leu ggo cot oca ggt Gly Pro Pro Giy t ca Ser 400 go aag aco atg Gly Lys Thr Met got Ala 405 1267 1315 1363 gtg oag Ott got Val Gin Leu Ala aac ttt tat oaa Asn Phe Tyr Gin gao ago ggo cac Asp Ser Gly His ato gc Ile Ala 420 ttt gat ago Phe Asp Ser gat atc cgc Asp Ile Arg 440 aac As n 425 ggo cat ogo act Gly His Arg Thr ttc gao gao oto Phe Asp Asp Leu aco cac ago Thr His Ser 435 ttc ttg tac Phe Leu Tyr 1411 1459 agg aat ctc atc Arg Asn Leu Ile g Cg Ala 445 gtt ttt gat gag Val Phe Asp Giu too too Ser Ser 455 too ata cog' oga Ser Ile Pro Arg gaa Glu 460 oat oto gat ggg His Leu Asp Gly qga tgt cag 1504 Giy Cys Gin tgatgagoag atcgaacaog cag <210> 324 <211> 468 <212> PRT <213> Corynebacterium giutamioum <400> 324 Met Lys Thr Glu Gin Ser Gin Lys Ala Gin 1 5 10 1527 Leu Ala Pro Lys Lys Ala Pro Giu Lys Pro Gin Arg Ile Arg Gin 25 Arg Pro Trp Leu Thr Ser Phe Thr Val 40 Leu Ile Ser Val Ala Trp Gin Ala Ala Thr Ile Ser Ala Leu Leu Phe Giu Leu Thr Leu Pro Leu Leu Thr Gly Gly 55 Ala Ile Asp Ile Ala Leu Gly Asn Thr Gly Asp Thr Leu Thr Thr Asp Leu Leu Asp Arg 70 75 Phe Val1 Thr Thr Arg 145 Gin Leu Ile Ser Ala 225 Val Thr Ala Val1 Val1 305 Val1 Ser Thr Ser Gly Thr Leu Ala Met 130 Thr Ser Val1 Ile Arg 210 Asp Lys Al a Lys As n 290 Gly Ala Ser Asp Phe 370 Val1 Pro Leu Gly 115 Arg Gly Leu Leu Ala 195 Lys Leu Ala Arg Phe 275 I Ie Th r Arg Val. Pro 355 Asnr G 1 r Ser Al a 100 Lys Se r Gin Val1 Thr 180 Al a Al a Thr Phe Glu 260 Ile Val1 Phe Se r Glu 340 Ala As n Al a Ser Arg Met Asn 135 Se r Leu Ile Vai Ala 215 Val1 Giu Ala Val1 Gly 295 Phe Gly Phe Leu Phe 375 Thr ValI Tyr Gly 120 Le u Arg Pro Met Pro 200 Ser Glu Asp Gin Giu 280 Tyr Ser Met Glu Ser 360 Arg Val1 Thr Ser Gin Gly Ile Leu 170 Al a Leu Trp Thr G.1 u 250 Met Leu Ala T yr Met 330 Ile Pro Ile Leu I le Gly Val1 125 Gin I le Asn Pro Ala 205 Gin Gly Lys Ala Leu 285 Gly Ser Gin Gin Pro 365 Gly Ala Arg 110 Arg Asp Asn Val1 Pro 190 Val1 Gln Ile Leu Arg 270 Ala His Le u Leu Pro 350 Leu Ph e Leu Arg Leu Ser Met Val1 175 Leu Ala Lys Arg Asp 255 Leu Leu Ile Ser Ala 335 Giu Gly Glu Ile Tyr Lys Ile ValI 160 Lys Thr Tyr Al a Val1 240 Leu Thr Val1 Thr Ala 320 Leu Arq Le u Le u Val Gly Pro Pro Gly Ser 385 390 395 400 Gly Lys Thr Met Ala Val Gin Leu Ala Giy Asn Phe Tyr Gin Pro Asp 405 410 415 Ser Giy His Ilie Ala Phe Asp Ser Asn Gly His Arg Thr Arg Phe Asp 420 425 430 Asp Leu Thr His Ser Asp Ile Arg Arg Asn Leu Ile Ala Val Phe Asp 435 440 445 Glu Pro Phe Leu Tyr Ser Ser Ser Ile Pro Arg Giu His Leu Asp Gly 450 455 460 Phe Giy Cys Gin 465 <210> 325 <211> 905 <212> DNA <213> Corynebacterium giutamicum <220> <221> COS <222> <223> RXA02225 (400> 325 caa act gag gag cgc ttt ggc gca gcg gct gat gaa goc ttg gca atc 48 Gin Thr Giu Giu Arg Phe Gly Ala Ala Ala Asp Giu Ala Leu Ala Ile 1 5 10 atg ttg aag gaa gct cgt ctg cag tcg ttg ctg act ttt gtg cgc caa 96 Met Leu Lys Giu Ala Arg Leu Gin Ser Leu Leu Thr Phe Val Arg Gin 25 ctt gtc cca gcg gtg ttt tct gtg ggt ctt ttg gct tat gcg tca ctg 144 Leu Val Pro Ala Val Phe Ser Val Gly Leu Leu Ala Tyr Ala Ser Leu 40 ttg gct ttt gac qqt gac ata act ggt qgt gag atg atc tcg gtg acg 192 Leu Ala Phe Asp Gly Asp Ile Thr Gly Gly Glu Met Ile Ser Val Thr 55 ttg ctg gtg cca cct tcg ttg act gtg ttg ggt gtg tcg ctt ggc atg 240 Leu Leu Val Pro Pro Ser Leu Thr Val Leu Gly Val Ser Leu Gly Met 70 75 atg aca qag att tgg gct agg gga cag gct tcg aca aaa agg gtc caa 288 Met Thr Giu le Trp Ala Arg Gly Gin Ala Ser Thr Lys Arg Val Gin 90 aac tta gtc act gaa ctg gat aag gcg gcc gct gag cca cga cct cag 336 Asn Leu Val Thr Giu Leu Asp Lys Ala Ala Ala Glu Pro Arg Pro Gin 100 105 110 cct gcc acc ttt gaa ttt gaa gag ggg atc acg gtg tgg gat cct tcg 384 Pro Ala Thr Phe Glu Phe Giu Glu Gly Ile Thr Val Trp Asp Pro Ser 115 120 125 aca cct Thr Pro 130 gag gca cgc gat Giu Ala Arq Asp gtg Val 135 att gat cgg gag Ile Asp Arg Giu gag gcg ott cag Giu Ala Leu Gin gtt Val1 145 cgc gaa gat gtc Arg Glu Asp Val gtg got cct cac Val Ala Pro His ogo Arg 155 gtc ago gtg ttt Val Ser Val Phe ggt gtg ctg aag Gly Val Leu Lys gat Asp 165 aat ttg aat cog Asn Leu Asn Pro ggc act atc gca Gly Thr Ile Ala ccg gag Pro Gin 175 atg ctg cgc Met Leu Arg oga ttg ggt Arg Leu Gly 195 got ott cat got Ala Leu His Ala agt tgt gag gao Ser Cys Gin Asp ato ttg ago Ile Len Ser 190 ott oca gat Leu Pro Asp got gat ctg aac Ala Asp Leu Asn cog ggg gag ttt Pro Gly Glu Phe gag Giu 205 aco ttg Thr Len 210 ato ggc gag gc Ile Gly Gin Ala gga Gly 215 ttg aat oto too Leu Asn Len Ser ggc caa ogo cag Gly Gin Arg Gin att got ttg gca. Ile Ala Leu Ala tto ttg got gtt Phe Leu Ala Val gat Asp 235 cot gag gtg cto Pro Gin Val Leu att Ile 240 ttg gat gaa cog Leu Asp Giu Pro acc Thr 245 acg ggg ttg gat Thr Gly Len Asp gtg aco otg gat Val Thr Len Asp gaa gtg Glu Val 255 gca cat ogo Ala His Arg acg tog aac Thr Ser Asn 275 gaa aag ott ogt Gin Lys Leu Arg ggc ogg aaa aco Gly Arg Lys Thr gto gto att Val Val Ile 270 oaa tot gat Gin Ser Asp cog acq tgg cac Pro Thr Trp His gtc gca aag cag Val Ala Lys Gin atg Met 285 ttt tog gaa ggg gtg aag Phe Ser Glu Gly Val Lys 290 <210> 326 <211> 294 <212> PRT tagatggogo agcatgagcg cgt <213> Corynebacterium gintamicum <400> 326 Gin Thr Gin Gin Arg Phe Gly Ala Ala Ala 1 5 10 Asp Giu Ala Leu Ala Ile Met Leu Lys Gin Ala Arg Len Gin Ser 25 Leu Val Pro Ala Val Phe Ser Val Gly Leu Leu Thr Phe Val Arg Gin Ala Ser Leu Len Leu Ala Len Ala Phe Asp Gly Asp Ile Thr Gly Gly Gin Met Ile Ser Vai Thr 55 Leu Leu Val Pro Pro Ser Leu Thr Val Leu Gly Val Ser Leu GJly Met 70 75 Met Thr Glu Ile Trp Ala Arg Gly Gin Ala Ser Thr Lys Arg Val Gin 90 Asn Leu Val Thr Glu Leu Asp Lys Aia Ala Ala Glu Pro Arg Pro Gin 100 105 110 Pro Ala Thr Plhe Glu Phe Glu Glu Gly Ile Thr Val Trp Asp Pro Ser 115 120 125 Thr Pro Glu Ala Arg Asp Val Ile Asp Arg Giu Leu Giu Ala Leu Gin 130 135 140 Val Arg Glu Asp Val Ile Val Ala Pro His Arg Val Ser Val Phe Glu 145 150 155 160 Gly Val Leu Lys Asp Asn Leu Asn Pro Met Gly Thr Ile Ala Pro Giu 165 170 175 Met Leu Arg Ala Ala Leu His Ala Ala Ser Cys Glu Asp Ile Leu Ser 180 185 190 Arg Leu Gly Ala Asp Leu Asn Met Pro Giy Giu ?he Glu Leu Pro Asp 195 200 205 Thr Leu Ile Gly Glu Ala Gly Leu Asn Leu Ser Giy Gly Gin Arg Gin 210 215 220 Arg Ile Ala Leu Ala Arg Phe Leu Ala Val Asp Pro Glu Val Leu Ile 225 230 235 240 Leu Asp Giu Pro Thr Thr Gly Leu Asp Ala Val Thr Leu Asp Glu Val 245 250 255 Ala His Arg Val Giu Lys Leu Arg Arg Gly Arg Lys Thr Val Val Ile 260 265 270 Thr Ser Asn Pro Thr Trp His Gly Val Ala Lys Gin Met Gin Ser Asp 275 280 285 Phe Ser Giu Gly Val Lys 290 <210> 327 <211> 1050 <212> DNA <213>' Coryriebacteriun giutamicum <220> <221> CDS <222> (101)..(1027) <223> RXA02253 <400> 327 tgaggacatt tcccaagtga aaggcttcgg cccgaaactt gcggaggctg tctatgaagg tcttcacgcg tcaaaataag tagatcgcta ggatgtaacc atg att caa tcc Met Ile Gin Ser 1 ggg gtc acg cac Giy Val Thr His act gat aag tct gca eaa gaa aat cct gtg aag tac Thr Asp Lys Ser Ala Gin Giu Asn Pro Val Lys Tyr 15 J- agg gac aat CIArg Asp Asn t~l ctg agc aca Leu Ser Thr aca cct gte atc Thr Pro Val Ile ace ggt atg tea Thr Giy Met Ser ggc gea ggt Giy Ala Gly tat gtg gcg Tyr Val Ala 211 259 gea gee ega gte Ala Ala Arg Val gaa gac ttg ggt Giu Asp Leu Giy eac aat His Asn att eca eca cag Ile Pro Pro Gin ate Ile 60 ate ctg gaa tta Ile Leu Giu Leu att Ile gat atg tgc get Asp Met Cys Ala egg Arg gaa. gat tet ccc Giu Asp Ser Pro gac aaa gtt gca Asp Lys Val Ala gtg tgc gat gtg Val Cys Asp Val tcc cgt gaa ttc Ser Arg Glu Phe cgc Arg gga age etc ace Gly Ser Leu Thr cag Gin 95 gtt gtt tea gag Val Vai Ser Giu ctg cgt Leu Arg 100 gat aag eag Asp Lys Gin gtg etg ate Val Leu Ile 120 gat ccc aeg gtg Asp Pro Thr Val ttt etg gaa gea Phe Leu Giu Ala ege gat gag Arg Asp Giu 115 cet ttg cag Pro Leu Gin 451 499 aag ega tte gat Lys Arg Phe Asp gtg ege ege ace Val Arg Arg Thr ggc agc Gly Ser 135 eaa ace ctt eag Gin Thr Leu Gin gtg Vai 140 ggt att gaa egt Gly Ile Glu Arg gaa Glu 145 ega ace gtg ctg Arg Thr Val Leu cct gtg aag gaa Pro Val Lys Giu gac Asp 155 get tea gtg gte Ala Ser Val Val gat acc teg gat Asp Thr Ser Asp tee gtq eat gat Ser Val His Asp ttg Leu 170 ege ege gee ate Arg Arg Ala Ile gaa Giu 175 tee teg ttt agg Ser Ser Phe Arg aca ate Thr Ile 180 gee aeg ege Ala Thr Arg ggc tea eca Gly Ser Pro 200 eag cac gte ace Gin His Val Thr gaa tea tte ggt Giu Ser Phe Gly ttc aaa eac Phe Lys His 195 tte ttg ceg Phe Leu Pro ege gac gee gac Arg Asp Ala Asp gtt gtg gac gtg Val Val Asp Val eg t Arg 210 aae eea Asn Pro 215 ttc tgg gtt eca Phe Trp Val Pro etg ege cea. ttt Leu Arg Pro Phe agg Arg 225 gga gtg gac aag Gly Vai Asp Lys eca gta tet gae tat gtg etc tee caa aaa ggc gea gaa gaa ttt ttg Pro Val Ser Asp Tyr Val Len Ser Gin Lys Gly Ala Gin Gin Phe Leu 230 235 240 245 aac aao ttt gtg gac atg ctc aaa gao atg ctt cog gga tac cgc oac 883 Asn Asn Phe Val Asp Met Len Lys Asp Met Len Pro Gly Tyr Arg His 250 255 260 gaa gqa aaa aac ttc atc aca ato ggt gtc ggo tgc acc ggt gga cac 931 Gin Gly Lys Asn Phe Ile Thr Ile Gly Val Gly Cys Thr Gly Giy His 265 270 275 cac aga tca gtt gcg gtg tct gaa gaa ota gcc aaa aga ato gca gat 979 His Arg Ser Val Aia Val Ser Gin Gin Len Ala Lys Arg Ile Ala Asp 280 285 290 oaq aoo aog otc gao gtg tot gta gta oao ogo gat att aao ogo oao 1027 Gin Thr Thr Len Asp Val Ser Val Val His Arg Asp Ile Asn Arg His 295 300 305 taggaaaggg gooaaotaat tga 1050 <210> 328 <211> 309 <212> PRT <213> Corynebacterium gintamioum <40'0> 328 Met Ile Gin Ser Thr Gly Val Thr His Thr Asp Lys Ser Aia Gin Gin 1 5 10 Asn Pro Vai Lys Tyr Arg Asp Asn Phe Thr Pro Val Ile Ile Thr Gly 25 Met Ser Gly Ala Gly Len Ser Thr Ala Ala Arg Val Leu Gin Asp Len 40 Gly Trp Tyr Val Ala His Asn Ile Pro Pro Gin Ile Ile Leu Giu Len 55 Ile Asp Met Cys Ala Arg Gin Asp Ser Pro Val Asp Lys Val Ala Val 70 75 Val Cys Asp Val Arq Ser Arg Gin Phe Arg Gly Ser Len Thr Gin Val 90 Val Ser Gin Leu Arg Asp Lys Gin Leu Asp Pro Thr Val Leu Phe Len 100 105 110 Gin Ala Arg Asp Glu Val Le Ile Lys Arg Phe Asp Asn Vai Arg Arg 115 120 125 Thr His Pro Len Gin Gly Ser Gin Thr Len Gin Val Gly Ile Gin Arg 130 135 140 Gin Arg Thr Val Len Ser Pro Val Lys Gin Asp Ala Ser Val Val Ile 145 150 155 160 Asp Thr Ser Asp Len Ser Val His Asp Len Arg Arg Ala Ile Gin Ser 165 170 175 Ser Phe Arg Thr Ile Ala Thr Arg Thr Gin His 180 185 Phe Gly Phe Lys His Gly Ser Pro Arg Asp Ala 195 200 Val Arq Phe Leu Pro Asn Pro Phe Trp Val Pro 210 215 Arg Gly Val Asp Lys Pro Val Ser Asp Tyr Val 225 230 235 Ala Giu Glu Phe Leu Asn Asn Phe Val Asp Met 245 250 Pro Gly Tyr Arg His Glu Gly Lys Asn Phe Ile 260 265 Cys Thr Gly Gly His His Arg Ser Val Ala Val 275 280 Lys Arg Ile Ala Asp Gin Thr Thr Leu Asp Val 290 295 Asp Ile Asn Arg His 305 <210> 329 <211> 558 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(535) <223> RXN01881 <400> 329 accggccctg cggcctcaac cgccgaccag cgcggcgcac taaagacaaa cttaagtatc ggagtcgaag aaaaaccaca Val1 Asp Glu 220 Le u Leu Thr Ser Se r 300 Thr Phe 205 Leu Se r Lys Ile Glu 285 Val1 Giu Val Pro Lys Met 255 Val Leu His aat As n ggt Gly ctc Leu gaa Giu ct C Leu gtc Val aat Asn aag Lys gag Giu tcc Ser ggt Gi y ccg Pro aac Asn tta Leu ggC Gly ga t Asp t cc Ser gt t Val1 aaa Lys ggc Gly aaa Lys caa Gin acc Thr cgt Arq 60 acc Thr acc Thr acc Thr 45 qtg Val1 tgg T rp gqc Gly 30 ct g Le u t ct Ser tta Leu cgc Arg gaa Gi u aac As n acattttgac tgtttcataa atg gcc aat ctq att Met Ala Asn Leu Ile 1 aaa acg ctt ctc gac Lys Thr Leu Leu Asp att ggc qtc gtc ggc Ile Gly Val Val Gly gta ctt act ggc atc Val Leu Thr Gly Ile tct gac ctg cgc atg Ser Asp Leu Arg Met 115 163 211 259 307 gct gtg gtg aeg cag cgt get gaa etc Ala Val Val Thr Gin Arg Ala Giu Leu 75 gac gtg gtg ett gga cet ttg ggt ttg Asp Val Val Leu Gly Pro Leu Gly Leu aac gcc acg gtg cgc gac gte etc ggt Asn Ala Thr Val Arg Asp Val Leu Gly 105 110 ggc ett gac acc aag gtg ggc aaa cct Gly Leu Asp Thr Lys Val Gly Lys Pro 120 125 acg cac caa cct ggc cgc cgc gct ggt Thr His Gin Pro Gly Arg Arg Ala Gly 135 140 gtgctcgacg agc <210> 330 (211> 145 <212> PRT <213> Corynebacterium glutamicum ga t Asp 80 gtt Val1 ttg Leu ceg Pro cga Arg gac ace gte Asp Thr Val gaa tgggca Glu Trp Ala 100 att gte gat Ile Val Asp 115 gge gaa gcg Gly Glu Ala 130 tgacctgatc get Ala tea Se r ott Leu cog Pro <400> 330 Met Ala Asn Leu Ilie Asn Leu Glu Asn Val Ser Lys Thr Trp 1 Lys Thr Leu Ile Gly Val Val Leu Thr Ser Asp Leu Asp Asp Thr ?he Glu Trp Gly Ilie Val 115 Val Gly Glu 130 Pro 145 <210> 331 Leu Val1 Gly Arg ValI Al a 100 Asp Ala 5 Asp Gi y Ile Met Al a Ser Le u Pro Gly Leu Giu Ala 70 Asp Asn Gly Thr Val As n Lys 55 ValI Val1 Ala Leu His 135 Ser Gly 40 Pro Val Val Thr Asp 120 Gin Le u 25 Gly Asp Thr Leu Val1 105 Thr Pro 10 Gly Gly Gin Gin Gi y 90 Arg Lys Gly Val. Gin Lys Thr Gly Arg Arg Ala 75 Pro Leu Asp Val Val'Gly Arg Arg 140 Thr Thr Va 1 Giu Gi y Leu Lys 125 Al a Gly Leu Ser Leu Leu Gly 110 Pro Gly Gly Asp Le u His Asn Giu Gly Phe Ser Leu Arg Glu As n Asp Val Le u Pro Arg <211> <212> <213> <220> <221> <222> <223> 564 DNA Corynebacterium giutamicum C DS (541) FRXA0 1881 <400> 331 accggccctg cggcctcaac cgccgaccag cgcggcgcac taaagacaaa cttaagtatc ggagtcgaag aaaaaccaca acattttgac tgtttcataa atg gcc aat ctg att 11 Met Ala Asn Leu Ile 1 aat ctc gag aac Asn Leu Giu Asn tcc aaa acc tgg Ser Lys Thr Trp tta aaa acg ctt Leu Lys Thr Leu ctc gac Leu Asp ggt gtc tcc Gly Val Ser ctc aat ggt Leu Asn Gly ggt gtt caa acc Gly Val Gin Thr ggc Gly gac cgc att ggc Asp Arg Ile Gly gtc gtc ggc Val Val Gly act ggc atc Thr Gly Ile 211 259 ggc gga aaa acc Gly Giy Lys Thr ctg ctg gaa gta Leu Leu Giu Val ctt Le u gaa aag Glu Lys ccg gat cag ggc Pro Asp Gin Gly cgt Arg 60 qtg tct cac aac Val Ser His Asn t ct Ser gac ctg cgc atq Asp Leu Arg Met gCt Ala ytg qty acg cag Val Val Thr Gin gct gaa ctc aat Ala Giu Leu Asn gac gac acc gtc Asp Asp Thr Val gct Ala gac gtg qtg ctt Asp Val Val Leu cct ttg qqt ttg Pro Leu Gly Leu gtt ttc gaa tgg Val Phe Glu Trp gca tca Ala Ser 100 aac gcc acg Asn Ala Thr qgc ctt gac Gly Leu Asp 120 g tg Val1 105 cgC gac gtc ctc Arg Asp Val Leu ggc ttg ggc att Gly Leu Gly Ile gtc gat ctt Val Asp Leu 115 cga aqc gcc Arg Ser Ala acc aag gtg ggg Thr Lys Vai Gly caa Gin 125 acc ttt tcc ggt Thr Phe Ser Gly ggg Gly 130 qac gca Asp Ala 135 cca acc tgg ccg Pro Thr Trp Pro cgc tgg ttc gcg Arg Trp Phe Ala acc ttg acc Thr Leo Thr 145 tgatcgtgct cgacgagccc acc <210> 332 <211> 147 <212> PRT <213> Corynebacterium giutanicum <400> 332 Met Ala Asri Leu Ile Asn Leu Giu Asn Vai Ser 1 5 10 Lys Thr Leu Leu Asp Giy Val Ser Leu Gly Vai Ile Giy Val Val Gly Leu Asn Giy Gly Gly Lys 40 Val Leu Thr Giy Ile Giu Lys Pro Asp Gin Gly 55 Ser Asp Leti Arg Met Ala Val Val Thr Gin Arg 70 75 Asp Asp Thr Vai Ala Asp Val Val Leu Giy Pro 90 Phe Giu Trp Ala Ser Asn Ala Thr Vai Arg Asp 100 105 Gly Ile Val Asp Leu Gly Leu Asp Thr Lys Vai 115 120 Gly Gly Arc; Ser Ala Asp Ala Pro Thr Trp Pro 130 135 Thr Leu Thr 145 <210> 333 <211> 813 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(790) <223> RXA00526 <400> 333 ggtggagcag gcggcggctc cttttagtcc tgcggcccct cgtttctgcc aaqcaaaccg tgggccaqgt qatttagcct Lys Gin Thr Arg Al a Le u Val1 Gi y Pro 140 Thr Thr Thr Val1 Giu Gly Leu Gin 125 Arg Gly Asp Leu His As n Giu Gly Phe Phe Le u Arg Giu As n Asp Val1 Le u Se r Al a atg Met acc Thr t cg Ser att cga Arg gtg Val1 gtt Val1 ggg gt c Val1 ggt Gly a cg Thr gat acc Thr ga t Asp 9gC Gly cca aac Asn cat His ggt Gly ga t att Ile 15 gtg Val1 aaa Lys ggc tttgaccctg cagcccctgc atg ago ctc atc gaa Met Ser Leu Ile Giu 1 tct gaa qgt gaa ctc Ser Giu Giy.Giu Leu cgt ggc gaa ttc gtg Arg Gly Giu Phe Val acg atg atg aac atc Thr Met Met Asn Ile tac acc ttg gat ggc 115 163 211 259 307 Ilie Gly Leu Leu Asp Lys Pro Thr Asp Gly Thr Tyr Thr Leu Asp Gly 60 S gtg gat gtg ttg gat atc agc gat gat gct ttg gcg agc cac cgc gct 355 c]Val Asp Val Leu Asp Ile Ser Asp Asp Ala Leu Ala Ser His Arg Ala 75 80 aaa tcg att ggt ttt gtg ttt cag aac ttc aat ctq att ggc cgq atc 403 Lys Ser Ile Gly Phe Vai Phe Gin Asn Phe Asn Leu Ile Gly Arg Ile 95 100 gat gcg ttg aag aat gtg gaa atg ccc atg atg tat qcg ggc att ccg 451 S Asp Ala Leu Lys Asn Val Giu Met Pro Met Met Tyr Ala Giy Ile Pro 105 110 115 S gct aag cag cgg aga agt cgt gcg gtt gaa tta ttg gaa atg gtc ggg 499 Ala Lys Gin Arg Arg Ser Arg Ala Val Glu Leu Leu Giu Met Val Giy 120 125 130 S atg ggt gag cgt ctc aac cat gag ccc aat gag ctt tcg ggt ggt cag 547 cI Met Giy Giu Arg Leu Asn His Giu Pro Asn Giu Leu Ser Giy Gly Gin 135 140 145 aag cag cgc gtg gcc att gct cgc gcg ttg gcg aac gat cct gag atc 595 Lys Gin Arg Val Aia Ile Ala Arg Ala Leu Ala Asn Asp Pro Giu Ile 150 155 160 165 att ctt qct gat gaa cca act ggt gcg ttg gat tct gca acg ggc cgg 643 Ile Leu Ala Asp Giu Pro Thr Giy Ala Leu Asp Ser Ala Thr Gly Arg 170 175 180 atg gtg atg gat att ttc cac cag ctc aac aag gag cag ggc aaa acc 691 Met Val Met Asp Ile Phie His Gin Leu Asn Lys Glu Gin Gly Lys Thr 185 190 195 atc gtg ttt att act cac aac cct gag ctt gct gat gaa tct gat cgg 739 Ile Val Phe Ile Thr His Asn Pro Giu Leu Ala Asp Giu Ser Asp Arg 200 205 210 gtg gtc acc atg gtt gac ggg cgc atc att ggg tct gag gtg aaa cac 787 Val Val Thi: Met Val Asp Gly Arg Ile Ile Gly Ser Giu Val Lys His 215 220 225 tca tgagccttgc agaatcaatt ctt 813 Ser 230 <210> 334 <211> 230 (212> PRT <213> Corynebacterium giutamicum <400> 334 Met Ser Leu Ile Giu Met Arg Asn Ile Val Lys Thr Tyr Asn Ile Gly 1 5 10 Ser Giu Giy Giu Leu Thr Vai Leu His Gly Vai Asp Phe His Vai Asp 25 Arg Gly Giu Phe Val Ser Vai Val Giy Thr Ser Gly Ser Giy Lys Ser Thr Met Met Asn Ile Ile Gly Leu Leu Asp Lys Pro Thr Asp Gly Thr 55 Tyr Thr Leu Asp Gly Val Asp Val Leu Asp Ile Ser Asp Asp Ala Leu 70 75 Ala Ser His Arg Ala Lys Ser Ile Gly Phe Val Phe Gin Asn Phe Asn 90 Leu Ile Gly Arg Ile Asp Ala Leu Lys Asn Val Giu Met Pro Met Met 100 105 110 Tyr Ala Gly Ile Pro Ala Lys Gin Arg Arg Ser Arg Ala Val Glu Leu 115 120 125 Leu Glu Met Val Gly Met Gly Glu Arg Leu Asn His Glu Pro Asn Glu 130 135 140 Leu Ser Gly Gly Gin Lys Gin Arq Val Ala Ile Ala Arg Ala Leu Ala 145 150 155 160 Asn Asp Pro Glu Ile Ile Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp 165 170 175 Ser Ala Thr Gly Arg Met Val Met Asp Ile Phe His Gin Leu Asn Lys 180 185 190 Giu Gin Gly Lys Thr Ile Val Phe Ile Thr His Asn Pro Giu Leu Ala 195 200 205 Asp Glu Ser Asp Arg Val Val Thr Met Val Asp cGIy Arg Ile Ile Gly 210 215 220 Ser Giu Vai Lys His Ser 225 230 <210> 335 <211> 1008 <212> DNA <213> Corynebacterium glutamicum <22 0> <221> CDS <222> (101)..(985) <223> RXN00733 <400> 335 acgqcqaggt tgtcggtatt ggaacgcaca cgaatttgct gaacacgtgc ggtacctacc gtgaaattgt tgaatcccaa gagactgcgc aggcgcaatc atg agt aat act gca 115 Met Ser Asn Thr Ala 1 ggc ccc cgc ggg cgt tcc cat cag gca gac gcc qcg ccg aat caa aag 163 Gly Pro Arg Gly Arg Ser His Gin Ala Asp Ala Ala Pro Asn Gin Lys 15 gca cag aat ttc gga cca tct gcc aaa agg ctt ttc gga att cta ggc 211 Ala Gin Asn cat gac cgt His Asp Arg GJiy Pro Ser Ala Arg Leu Phe Gly Ile Leu Gly gtc ctg age Val Leu Ser aac acc tta att Asn Thr Leu Ile ttt Ph e gtt atc ttc cta Vai Ile Phe Leu 259 gtt gga Vai Giy ctt ace gtc ttg Leu Thr Val Leu eca tgg ttg ctg Pro Trp Leu Leu ggt Gi y aaa gcc ace aac Lys Ala Thr Asn gtg ttt gaa gga Val Phe Giu Gly ttc Phe eta tot aag cge Leu Ser Lys Arg eqg get ggt geg Pro Ala Gly Ala aag gaa gat ate Lys Giu Asp Ile qeg eag ttg eag Ala Gln Leu Gin gca ggt aaa eat Ala Gly Lys His aat cag Asn Gin 100 get tee atl Ala Ser Met: ttt gaa aaa Phe Giu Lys 120C gaa gac atg aac Giu Asp Met Asn ett Le u 110 gtt eca ggc tea Val Pro Gly Ser gge att gat Gly Ile Asp 115 gct tat etc Ala Tyr Len 451 499 tta gee atg ate Leu Ala Met Ile gga etg gtg ate Giy Len Val Ile ate ggt Ile Gly 135 age ctg Ser Leu ttg teg ttg Leu Ser Len 140 ttc eag geg egg Phe Gin Ala Arg atg Met 145 etc aac ego ate Len Asn Arg Ile gtg ValI 150 caa agt gee atg Gin Ser Ala Met ca e His 155 egg etg ego atg Arg Len Arg Met gtg gag gaa aaa Val Gin Giu Lys 547 595 643 eac ege eta ceg His Arg Leu Pro age tat ttc gat Ser Tyr Phe Asp ate aaa egt ggt Ile Lys Arg Giy gat ctg Asp Len 180 ctt age egt Leu Ser Arg eaa ace ttg Gin Thr Leu 200 ace aac gat gtg Thr Asn Asp Val ga t Asp 190 aat ate ggt eaa Asn Ile Gly Gin tee ctg eaa Ser Leu Gin 195 ate ggt gtg Ile Gly Vai tea cag geg ate Ser Gin Ala Ile tee eta ctg ace Ser Leu Leu Thr ttg gtg Leu Val 215 atg atg ttt ate Met Met Phe Ile tee eca etg etc Ser Pro Leu Leu etc gtg geg etg Leu Val Ala Leu gta Val1 230 tee att ceg gte Ser Ile Pro Val ace Thr 235 ate gtg gte act Ile Val Val Thr gtg Val1 240 gtg gtt geg age Vai Vai Ala Ser tee eag aaa ete Ser Gin Lys Len geg gaa eag tgg Ala Giu Gin Trp eag ace ggt att Gin Thr Gly Ile ttg aat Leu Asn 260 geg ego etg gag gaa ace tac tet gge eae gee gtg gtt aag gtt tte Ala Arg Leu Gin Gin Thr Tyr Ser Gly His Ala Vai Val Lys Vai Phe 265 270 275 gga cac caa aag gat gtt caa gaa gca ttc gag gaa gaa aat caa gct 979 Gly His Gin Lys Asp Val Gin Glu Ala Phe Giu Giu Giu Asn Gin Ala 280 285 290 tgt gta taaggccagc tttggtgccc agt 1008 Cys Val 295 (210> 336 <211> 295 <212> PRT <213> Corynebacterium giutamicum <400> 336 Met Ser Asn Thr Ala Gly Pro Arg Gly Arg Ser His Gin Ala Asp Ala 1 5 10 Ala Pro Asn Gin Lys Ala Gin Asn Phe Gly Pro Ser Ala Lys Arg Leu 25 Phe Gly Ile Leu Gly His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe 40 Leu Ala Val Leu Ser Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu 55 Gly Lys Ala Thr Asn Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met 70 75 Pro Ala Gly Ala Ser Lys Giu Asp Ile Ile Ala Gin Leu Gin Ala Ala 90 Gly Lys His Asn Gin Ala Ser Met Met Glu Asp Met Asn Leu Val Pro 100 105 110 Gly Ser Gly Ile Asp Phe Giu Lys Leu Ala Met Ile Leu Gly Leu Val 115 120 125 Ile Gly Ala Tyr Leu Ile Gly Ser Leu Leu Ser Leu Phe Gin Ala Arg 130 135 140 Met Leu Asn Arg Ile Val Gin Ser Ala Met His Arg Leu Arg Met Giu 145 150 155 160 Val Giu Giu Lys Ile His Arg Leu Pro Leu Ser Tyr Phe Asp Ser Ile 165 170 175 Lys Arg Gly Asp Leu Leu Ser Argj Val Thr Asn Asp Val Asp Asn Ile 180 185 190 Gly Gin Ser Leu Gin Gin Thr Leu Ser Gin Ala Ile Thr Ser Leu Leu 195 200 205 Thr Val Ile Gly Val Leu Val Met Met Phe Ile Ile Ser Pro Leu Leu 210 215 220 Ala Leu Val Ala Leu Val Ser Ile Pro Val Thr Ile Val Val Thr Val 225 230 235 240 Val Val Ala Ser Arg Ser Gin Lys Leu Phe Ala Glu Gin Trp Lys Gin 245 250 255 Thr Gly Ile Leu Asn Ala Arg Leu Giu Giu Thr Tyr Ser Gly His Ala 260 265 270 Val Val Lys Val Phe Gly His Gin Lys Asp Vai Gin Giu Ala Phe Glu 275 280 285 Glu Glu Asn Gin Ala Cys Val 290 295 <210> 337 <211> 508 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(508) <223> FRXA00733 <400> 337 acggcgaggt tgtcggtatt ggaacgcaca cgaatttgct gaacacgtgc ggtacctacc gtgaaattgt tgaatcccaa gagactgcgc aqgcgcaatc atg aqt aat act gca 11 Met Ser Asn Thr Ala 99c Gly gca Ala cat His gtt Val1 gtg Val1 aag Lys gct Al a ttt Phe ccc Pro cag Gin qa c Asp gga Gly gtg Val1 gaa Glu tcc Ser ga a Glu cgt Arg gqa Gly acc Thr gtc Val1 qga Gly atc Ile gaa Glu qcc Ala tcc Ser cca Pro tta Leu ttg Leu ttc The 75 gcg Al a gac Asp atg Met cag Gin gcc Al a ttt Phe cca Pro t ct Ser ttg Leu aac Asn ctc Leu gca Ala aaa Lys gtt Val1 t gg T rp aag Lys cag Gin ctt Leu 110 qga Gly 1 gcg Ala ttc Phe ct a Leu qgt Gly ccq Pro ggt Gly ggc Gly ccq Pro gga Gly gcc Ala aaa Lys gct Al a aaa Lys tca Ser aat caa Asn Gin att, cta Ile Leu gtc ctg Val Leu gcc acc Ala Thr ggt gcg Giy Ala cat aat His Asn 100 ggc att Gly Ile 115 aag Lys ggci Gi y agc Se r aac As n tca Ser cag Gin gat Asp gq atc gqt gct tat ctc Val Ile Giy Ala Tyr Leu 120 125 130 att cgt agc 508 Ile Arq Ser 135 <210> 338 <211> 136 (212> PRT <213> Corynebacteriun glutamicum <400> 338 Met Ser Asn Thr Ala Gly Pro Arg Gly Arg Ser His Gin Ala Asp Ala 1 5 10 Ala Pro Asn Gin Lys Ala Gin Asn Phe Gly Pro Ser Ala Lys Arg Leu 25 Phe Gly Ile Leu Gly His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe 40 Leu Ala Val Leu Ser Vai Gly Leu Thr Val Leu Gly Pro Trp Leu Leu 55 Gly Lys Ala Thr Asn Vai Val Phe Glu Gly Phe Leu Ser Lys Arg Met 70 75 Pro Ala Gly Ala Ser Lys Glu Asp Ile Ile Ala Gin Leu Gin Ala Ala 90 Gly Lys His Asn Gin Ala Ser Met Met Giu Asp Met Asn Leu Val Pro 100 105 110 Gly Ser Gly Ile Asp Phe Giu Lys Leu Ala Met Ile Leu Gly Leu Val 115 120 125 Ile Gly Ala Tyr Leu Ile Arg Ser 130 135 <210> 339 <211> 692 <212> DNA <213> Corynebacterium glutamicum <220> <221> COS <222> (669) <223> RXA00735 <400> 339 gqt 000 acc qqt qog gqc aag aco aca ttg gtg aat ctg atc atg cgt 48 Gly Pro Thr Gly Ala Gly Lys Thr Thr Leu Val Asn Leu Ile Met Arg 1 5 10 ttc tao gac atc aac ago ggt too ato aot ott ggt gaa aoa goa oaa 96 Phe Tyr Asp Ile Asn Ser Gly Ser Ile Thr Leu Gly Glu Thr Ala Gin 25 gac goc gtg gat atc cyc aco atg got aga gaa gat ctg cga tca oga 144 Asp Ala Val Asp Ile Arg Thr Met Ala Arg Giu Asp Leu Arg Ser Arg 40 acc ggc atg gtg ttg cag gat acg tgg ctg ttt gcc gga acc atc agg 192. Thr Gly Met Val Leu Gin Asp Thr Trp Leu Phe Ala Gly Thr Ile Arg 55 gat aac att, ctt tac ggt aga cct gaa gca act gag gaa gaa atg ctt 240 Asp Asn Ile Leu Tyr Gly Arg Pro Glu Ala Thr Glu Glu Giu Met Leu 70 75 gct gcq tcc aag gcc gcc tac gtg gat cgt ttt gtc cgt tcc ctg cca 288 Ala Ala Ser Lys Ala Ala Tyr Val Asp Arg Phe Val Arg Ser Leu Pro 90 gaa qgc tac gac acc gta ctt qat gat gaa gcc atg aac cta tcg gtg 336 Glu Gly Tyr Asp Thr Val Leu Asp Asp Glu Ala Met Asn Leu Ser Val 100 105 110 ggt gaa cgc: cag ctg atc acc atc gcg cgt gca ttc ttg gct aat ccc 384 Gly Giu Arg Gin Leu Ile Thr Ile Ala Arg Ala Phe Leu Ala Asn Pro 115 120 125 cga ctg ctq att ctq gat gaa gcc acc tca tcg gtg gat acg cgt acc 432 Arg Leu Leu Ile Leu Asp Glu Ala Thr Ser Ser Val Asp Thr Arg Thr 130 135 140 gaa ttg ttg att cag cgc gcc atg tcc aag ctg cgc caa gac cgc acc 480 Giu Leu Leu Ile Gin Arg Ala Met Ser Lys Leu Arg Gin Asp Arg Thr 145 150 155 160 gcc ttc gtc: atc gcg cac cgg ttg tcc acq att cgt gat gcc aac ctg 528 Ala Phe Val Ile Ala His Arg Leu Ser Thr Ile Arg Asp Ala Asn Leu 165 170 175 att ttg atg atg aaa gac ggc gag atc gtg gag cag ggc aat cac cgt 576 Ile Leu Met Met Lys Asp Gly Giu Ile Val Glu Gin Gly Asn His Arg 180 185 190 gag ttg atg gcc ctg gag ggc gca tat tqg gag ttg tat aac tcc caa 624 Giu Leu Mel: Ala Leu Giu Gly Ala Tyr Trp Giu Leu Tyr Asn Ser Gin 195 200 205 ttc aac gcc ccc gcg aaa qaa gaa tta cag gct gac gga gat cac 669 Phe Asn Ala Pro Ala Lys Glu Giu Leu Gin Ala Asp Gly Asp His 210 215 220 tgatgatttc ttcttaggct ttc 692 <210> 340 <211> 223 <212> PRT <213> Corynebacterium giutamicum <400> 340 Gly Pro Thr Gly Ala Gly Lys Thr Thr Leu Val Asn Leu Ile Met Arg 1 5 10 Phe Tyr Asp Ile Asn Ser Gly Ser Ile Thr Leu Giy Giu Thr Ala Gin 25 Asp Ala Val. Asp Ile Arg Thr Met Ala Arg Giu Asp Leu Arg Ser Arg 40 Gly Asn Al a Gly Giu Le u 130 Leu Phe Le u Le u Asn 210 Met: Ile Ser T yr Arcl Le u Leui Val1 Me t Met: 195 Ala Le u Tyr Ala Thr Leu Leu Gin Ala 165 Lys Leu Ala Gin Gly Ala Val1 Ile Asp Arq 150 His Asp Giu Lys Asp 55 Arg Tyr Leu Thr Glu 135 Ala Arg Gly Gly Glu 215 Th r Pro Val1 Asp Ile 120 Al a Met Le u Glu Ala 200 Glu Trp Giu Asp Asp 105 Ala Thr Ser Ser Ile 185 T yr Leu Ph e Thr Phe Ala Ala Ser Leu 155 Ile Glu Giu Ala Al a Giu Val1 Met Phe Val1 140 Arg Arg Gin Le u Asp 220 Thr Giu Ser Leu 110 Al a Thr Asp Ala As n 190 Asn Asp <210> 341 <211> 1986 <212> DNA <213> Coryriebacterium giutamicum <220> <221> CDS <222> (1963) <223> RXA00878 <400> 341 cgagattagg tccgcttcag ttgtggtggc tccgaatctg atqaacaatq atcattccta attcatttac atctttatca aagagagcca ccacctacta atg cga ctt ctt ggt Met Arg Leu Leu Gly 1 cga att tta aaa acc acg tct gcg ctt tgg ccc tac tat ctc gga att Arg Ile Leu Lys Thr Thr Ser Ala Leu Trp Pro Tyr Tyr Leu Gly Ile 15 atc gtc gta tcc att qtq atc gcg gcq ttq tcq ctg ctg tcg ccg ttt Ile Val Val Ser Ile Val Ile Ala Ala Leu Ser Leu Leu Ser Pro Phe 115 163 211 att etc cgc Ile Leu Arq gaa gca aca Glu Ala Thr gat tee Asp Ser att gtt tct gca Ile Val Ser Ala ace gga tet Thr Gly Ser 259 aac acc Asn Thr gtc gat gca gtt Val Asp Ala Val cgc act att att Arg Thr Ile Ile tta get tta gee Leu Ala Leu Ala ctg Leu ttt gte gca agc Phe Val Ala Ser ctc aat aeg gtg Leu Asn Thr Val atg Met ace aac ate ggt Thr Asn Ile Gly 307 355 403 tac ate ggt gat Tyr Ile Gly Asp atg gea tet egt Met Ala Ser Arg ege cag att etg Arg Gin Ile Leu gee aeg Ala Thr 100 ege tat tac Arq Tyr Tyr eag gte ace Gin Val Thr 120 gea Al a 105 aag ctg ttg geg Lys Leu Leu Ala ect eag aag tat Pro Gin Lys Tyr ttt gat aat Phe Asp Asn 115 ate aae gqe Ile Asn Gly 451 499 gge aec ate ate Giy Thr Ile Ile gee Al a 125 ege ctt gat ega Arg Leu Asp Arq ate acg Ile Thr 135 eaq tte atg cag Gin Phe Met Gin tte tee aac aac Phe Ser Asn Asn ttc ccc atg cte Phe Pro Met Leu ace atg gtg ges Thy Met Val Ala etg att att tee Leu Ile Ile Ser geg Ala 160 att ttc tae tgg Ile Phe Tyr'Trp. 547 595 643 etg gea att etg Leu Ala Ile Leu at g Leui 170 gee atg ttg tte Ala Met Leu Phe ccg Pro 175 att tac atg tgg Ile Tyr Met Trp ctg aeg Leu Thr 180 geg ttg aca Ala Leu Thr gaa ate gac Giu Ile Asp 200 tcg Se r 185 aaa age tgg aag Lys Arg Trp Gin tat gag ggc gag Tyr Glu Gly Glu aaa aac eat Lys Asn His 195 ggc cag gte Gly Gin Val gtg get aae gge Val Ala Asn Gly tta get gag gtt Phe Ala Glu Val gte Val1 210 aag gtt Lys Val 215 gtt: aaa teA tte Val Lys Ser Phe gtc Val1 220 gca gag ace age Ala Giu Thr Arg etg get gat ttc Leu Ala Asp Phe ggt Gly 230 ggg egt: tac gge Gly Arc] Tyr Gly aca gta gag att Thr Val Ala Ile egg eag eaa tee Arg Pro Gin Ser ggt Gly 245 tgg tgg caecage Trp Trp His Arg gat act etc egt Asp Thr Leu Arg gge Gi y 255 gag gca eta aat Ala Ala Leu Asn ate ate Ile Ile 260 ttc ctg gee Phe Leu Ala att Ile 265 cac etg etg att His Leu Leu Ile tae ege ace ttg Tyr Arg Thr Leu cac gge eat His Gly His 275 ttc ace atc Phe Thr Ile 280 ggc gac atg gtc Gly Asp Met Val atg Met 285 ctc atc cag ctt Leu Ile Gin Leu gte Val1 290 ace atg gcg Thr Met Ala cag caa Gin Gin 295 ceg gtg tac atg Pro Vai Tyr Met agc tac ate gtc Ser Tyr Ile Vai tcc gcg cag cgc Ser Aia Gin Arg ate gec ggc tee Ile Ala Gly Ser gac tae ttc gag Asp Tyr Phe Gin gte Val1 320 atg gcg eag cag Met Ala Gin Gin 1027 1075 1123 gag eec ace gee Giu Pro Thr Ala aat Asn 330 aag gag ctt gte Lys Gin Len Val gee ace etc gee Ala Thr Len Ala tea gac Ser Asp 340 act eca ege Thr Pro Arg eea gcg atg Pro Ala Met 360 agt gtg qgc aeg Ser Val Gly Thr ccc Pro 350 gee geg etg ccc Ala Ala Leu Pro get gga gaa Ala Gly Glu 355 gaa gge aag Gin Gly Lys 1171 1219 gaa ttc aaa aac Gin Phe Lys Asn ace ttc gee tac Thr Phe Aia Tyr eeg gtt Pro Val 375 att tec gac gtg Ile Ser Asp Val att ace gee ege Ile Thr Ala Arg cac His 385 ggc gag cgc ate Gly Glu Arg Ile geg Ala 390 ttg gte ggt gaa Len Val Gly Gln gge gge ggt aaa Gly Gly Gly Lys tee Ser 400 ace ctg gtc aac Thr Leu Val Asn 1267 1315 1363 ctg tta ggt etg Leu Len Gly Leu tae Tyr 410 aaa eea aac age Lys Pro Asn Ser agc ett gea gta Ser Leu Ala Val tgt gge cys Gly 420 gtg gat gtt Val Asp Vai gtg gte ttc Val Val Phe 440 gat etg act tee Asp Len Thr Ser gag Gin 430 qaa ctt cgc gea Giu Leu Arg Ala tee gtg ggt Ser Val Gly 435 gca gaa aae Ala Gin Asn 1411 1459 cag gac gee age Gin Asp Ala Ser tte tet gga tet Phe Ser Gly Ser ate gee Ile Ala 455 tac ggt ege eca Tyr Gly Arg Pro gee ace ege gaa Ala Thr Arg Giu ate ate gaa gtg Ile Ile Giu Val get Ala 470 aag aaa gee aae Lys Lys Ala Asn eat gag tte att His Giu Phe Ile tee Ser 480 gee ttc ect gaa Ala Phe Pro Gin gga Gly 485 1507 1555 1603 1651 tat gaa ace gte Tyr Gin Thr Val gte Val1 490 ggt gaa ege gga Giy Giu Arg Gly aaa ett tet ggt Lys Len Ser Gly gge eag Gly Gln 500 aag eag ege Lys Gin Arg tet gtg gea egg Ser Val Aia Arg gee Ala 510 atg ctt aaa gat Met Len Lys Asp gee eca ctt Ala Pro Len 515 ctt gtt ctc gat qaa gcc acc tct Leu Val Leu Asp Glu Ala Thr Ser 520 525 gca gtc caa gcc ggt ttg gaa cag Ala Val Gin Ala Gly Leu Giu Gin 535 540 atg atc gcc cac cgc ctg tcc acc Met Ile Ala His Arg Leu Ser Thr 550 555 acc atc caa aac gga cgg gtt gaa Thr Ile Gin Asn Gly Arg Val Glu 570 gca gtc tca ggc gyt atc tat tcc Ala Val Ser Gly Gly Ile Tyr Ser 585 aca gca gaa gcc gac cgg gag cgt Thr Ala Giu Ala Asp Arq Giu Arg 600 605 gat gca cca gct gaa gaa gag gac Asp Ala Pro Ala Giu Giu Giu Asp 615 620 <210> 342 <211> 621 <212> PRT <z213> Corynebacterium giutamicui <400> 342 Met Arg Leu Leu Gly Arq Ile Leu 1 5 Tyr Tyr Leu Gly Ile Ile Val Vai Leu Leu Ser Pro Phe Ile Leu Arg 40 Ala Val Thr Giy Ser Asn Thr Val 55 Phe Leu Ala Leu Ala Leu Phe Val Thr Asn Ile Gly Gly Tyr Ile Gly Gin Ile Leu Ala Thr Arg Tyr Tyr 100 Lys Tyr Phe Asp Asn Gin Val Thr 115 120 Arg Ser Ile Asn Gly Ile Thr Gin 130 135 gca ctg gat acc aag tct gag Ala Leu Asp Thr Lys Ser Giu 530 ctg atg gaa aac cgc acc acc Leu Met Glu Asn Arg Thr Thr 545 atc gca ggc gtc gat acc atc Ile Ala Gly Val Asp Thr Ile 560 gag gtc gga tct cct acc gag Giu Val Giy Ser Pro Thr Glu 575 580 gaa ctg ctg cgc ctg acc aac Glu Leu Leu Arg Leu Thr Asn 590 595 ctg cgc gcc ttt ggt ttc act Leu Arg Ala Phe Giy Phe Thr 610 tagccccgcg aaagaacaat ccc 1699 1747 1795 1843 1891 1939 1986 Lys Ser Glu Asp Ala Asp Ala 105 Gly Phe Thr 10 Ile Al a Ala Se r Val1 90 Lys Thr Met Ser Ile Asp Thr Le u Ala Leu Ile Ser 140 Ala Ala Ser Arg Asn Ser Ala Ala 125 Phe T rp Leu Val1 Ile Val Met Pro Leu Asn Phe Phe Pro Met Leu Ile Thr Met Val Ala Val Leu Ile Ile Ser Ala 145 150 155 160 Ile Phe Tyr Trp Pro Leu Ala Ile Leu Leu Ala Met Leu Phe Pro Ile 165 170 175 Tyr Met Trp Leu Thr Ala Leu Thr Ser Lys Arg Trp Gin Lys Tyr Glu 180 185 190 Gly Glu Lys Asn His Glu Ile Asp Val Ala Asn Gly Arg Phe Ala Glu 195 200 205 Val Val Gly Gin Val Lys Val Val Lys Ser Phe Val Ala Glu Thr Arg 210 215 220 Glu Leu Ala Asp Phe Gly Gly Arg Tyr Gly Lys Thr Val Ala Ile Thr 225 230 235 240 Arg Pro Gin Ser Gly Trp Trp His Arg Met Asp Thr Leu Arg Gly Ala 245 250 255 Ala Leu Asn Ile Ile Phe Leu Ala Ile His Leu Leu Ile Phe Tyr Arg 260 265 270 Thr Leu His Gly His Phe Thr Ile Gly Asp Met Val Met Leu Ile Gin 275 280 285 Leu Val Thr Met Ala Gin Gin Pro Val Tyr Met Met Ser Tyr Ile Val 290 295 300 Asp Ser Ala Gin Arg Ala Ile Ala Gly Ser Arg Asp Tyr Phe Glu Val 305 310 315 320 Met Ala Gin Gin Val Glu Pro Thr Ala Asn Lys Glu Leu Val Asp Ala 325 330 335 Thr Leu Ala Ser Asp Thr Pro Arg Ile Ser Val Gly Thr Pro Ala Ala 340 345 350 Leu Pro Ala Gly Glu Pro Ala Met Glu Phe Lys Asn Val Thr Phe Ala 355 360 365 Tyr Glu Glu Gly Lys Pro Val Ile Ser Asp Val Ser Ile Thr Ala Arg 370 375 380 His Gly Glu Arg Ile Ala Leu Val Gly Glu Ser Gly Gly Gly Lys Ser 385 390 395 400 Thr Leu Val Asn Leu Leu Leu Gly Leu Tyr Lys Pro Asn Ser Gly Ser 405 410 415 Leu Ala Val Cys Gly Val Asp Val Lys Asp Leu Thr Ser Glu Glu Leu 420 425 430 Arg Ala Ser Val Gly Val Val Phe Gin Asp Ala Ser Leu Phe Ser Gly 435 440 445 Ser Ile Ala Glu Asn Ile Ala Tyr Gly Arg Pro Gly Ala Thr Arg Glu 450 455 460 Glu Ile Ile Glu Val Ala Lys Lys Ala Asn Ala His Glu Phe Ile Ser 465 470 475 480 Ala Leu Lys Thr Asn 545 Val1 Ser Arg Phe Phe Ser Asp Lys 530 Arg Asp Pro Leu Gl y 610 Pro Gl y Al a 515 Ser Thr Thr Thr Thr 595 Phe Giu Gly 500 Pro Giu Thr Ile Glu 580 As n Gly 485 Gin Leu Gin Leu Val1 565 Leu Ser Tyr Lys Leu Ala Met 550 Thr Ala Thr Glu Gin Val1 Val1 535 Ile Ile Val1 Ala Thr Arg Leu 520 Gin Ala Gin Ser Glu 600 Val1 490 Ser Glu Gly Arg Gly 570 Gly Asp Glu Al a Thr Giu 540 Ser Val1 Tyr Glu Arg Arg Ser 525 Gin Thr Gi u Ser Arg 605 Lys Le u Asp Gi u Gly 560 Gly Leu Al a Thr Giy Asp Ala Pro Ala Giu Glu Glu Asp <210> 343 <211> 1713 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1690) <223> RXN01.191 <400> 343 cgctgctttc acgcaactga aaccgcaccg gatcaagtta cgtgttggtg gccqtcgcgg ggttggtagg gccctgggcg ga t Asp ctg Le u Gi y cg c aag Lys ctt Leu agc Ser gag gca Ala gct Ala atg Met ttq ccg Pro ggC Gly Arg gcg agc Ser gtt ValI gcg Ala gcg cgc Arg 15 t cg Se r gag Glu agt tttggggttg ttctttgtgg gtq ggt gga ctc gtc Val Gly Gly Leu Val 1 qtt gta gtg ttc gcg Val Val Val Phe Ala ctg ggc acg tqg tgg Leu Gly Thr Trp Trp gqg ate gcg gqq ctg Ala Ile Ala Gly Leu gat gcg aac acg att Arg Giu Asp Vai Leu Arg Ala Val Ser Leu Asp Ala Asn Thr Ile gaa Glu aeg gcg ggg cge Thr Ala Gly Arg ggc Gly gac gtg att tcg Asp Val Ile Ser atc gcg gat gat Ile Ala Asp Asp egg gag gtg tcc Arg Giu Val. Ser geg gcg agc ace Ala Ala Ser Thr gtg Val1 gtg ccg ctg atg Val Pro Leu Met gtg cag Val Gin 100 gcg ggc ttt Ala Gly Phe tgg cgc etc Trp Arg Leu 120 acc Thr 105 gtg gtg att tee Val Val Ile Ser ttt ggc atg gcg Phe Gly Met Ala gcg gtt gat Ala Vai Asp 115 tat tgg ace Tyr Trp Thr ggc ctt gte ggt Giy Leu Val Gly gte gcg ate ccg Val Ala Ile Pro acg ttg Thr Leu 135 cgc gtc tat tta Arg Val Tyr Leu cgc tca ggt ccg Arg Ser Gly Pro ctt Leu 145 tat acg egt gag Tyr Thr Arq Glu ege Arg 150 gag gcc ttt ggg Giu Ala Phe Gly gtg Val1 155 cge aeg cag egg Arg Thr Gin Arg gte ggc gca gtc Val Gly Ala Val ggc gcg gaa acc Gly Ala Giu Thr cge get ttc ege Arg Ala Phe Arg gca Ala 175 gaa gat aea gaa Glu Asp Thr Giu tta aag Leu Lys 180 egt atc gac Arg Ile Asp ttc agg ttc Phe Arg Phe 200 gcc tcc ggc gaa Ala Ser Gly Glu gcc Ala 190 cge gac att tcc Arg Asp Ile Ser att tet gtt Il'e Ser Val 195 geg gaa tge Ala Giu Cys etc aea tgq gea Leu Thr Trp Ala tee ege aae aae Ser Arg Asn Asn ate ace Ile Thr 215 etc: gtg etc ate Leu Val Leu Ile ggc ace gge ttt Gly Thr Gly Phe tac T yr 225 etg gte aae ate Leu Val Asn Ile gat Asp 230 ctg gte aee gte Leu Val Thr Val ggc Gly 235 qea gte tea ace Ala Val Ser Thr gee Ala 240 gea etg ate ttc Ala Leu Ile Phe ega etc ttc ggt Arg Leu Phe Gly cca Pro 250 ate gge aeg etc Ile Gly Thr Leu gge atg ttc tee Gly Met Phe Ser gac ate Asp Ile 260 eaa tee gee Gin Ser Ala gca teg aae Ala Ser Asn 280 gca teg etg ate Ala Ser Leu Ile atg gtg gge gtt Met Val Gly Val att aae geg Ile Asn Ala 275 age aec get Ser Thr Ala eag gte age ggc Gin Val Ser Gly ace T hr 285 teg ceg geg tet Ser Pro Ala Ser tta aeg ett tte gac gte tee eac eac tat eac act gca cee gte ate Leu Thr Leu Phe Asp Val Ser His Hi Tyr His Thr Ala Pro Val Ile 1027 300 305 aag Lys 310 aat gca tcc gtg Asti Ala Ser Val cag Gin 315 ctg gaa eca ggg Leu Glu Pro Gly cac atc gcc att His Ile Ala Ile gtg Val1 325 1075 1123 ggt gcg ace ggc Gly Ala Thr Gly got Ala 330 qgt aaa agc acg Gly Lys Ser Thr gcc etc att gog Ala Leu Ile Ala gca ggc Ala Gly 340 ctg etc age Leu Leu Ser tct aao gtc Ser Asti Val 3 60 act tcc ggg cag Thr Ser Gly Gin gct ctc ggc gga Ala Leu Gly Gly teg agt ttt Ser Ser Phe 355 atg gte age Met Val Ser 1171 1219 gaa ecg gaa gca Giu Pro Glu Ala ttg Leu 365 ego cag aag ate Arg Gin Lys Ile caa gaa Gin Giu 375 ate cac tgc tte Ile His Cys Phe gga tet gtt tta Giy Ser Val Leu aat ctt cgt ate Asni Leu Arg Ile ego ccc gaa gee Arg Pro Giu Ala gat geg gao ate Asp Ala Asp Ile gee gtt etc gcc Ala Val Leu Ala ga t Asp 405 1267 1315 1363 att ggt gat tee Ile Gly Asp Ser tgg Trp 410 ttg gag ege tta Leu Giu Arg Leu ceg Pro 415 eaa gge ata gae Gin Gly Ile Asp ace ate Thr Ile 420 gtg ggt gat: Val Gly Asp geg ett get Ala Leu Ala 440 get tte egt tta Ala Phe Arg Leu tet gtg gaa aac Ser Val Glu Asn eag ate atg Gln Ile Met 435 ate ott gat Ile Leu Asp 1411 1459 ege gta eat ttg Arg Val His Leu gee Ala 445 gac eta gea ate Asp Leu Ala Ile gaa gea Giu Ala 455 aeg get gaa tea Thr Ala Glu Ser tet gat eat Ser Asp His gea aaa Ala Lys 465 eag ctt gaa gat Gin Leu Giu Asp gea Al a 470 gee ett: aaa gte Ala Leti Lys Val gaa aae aga tea Glu Asti Arg Ser ate ate gtg get Ile Ile Val Ala cac His 485 1507 1555 1603 ege cte aae caa Arg Leu Asni Gin geg Al a 490 aaa ace gee gat Lys Thr Ala Asp ege Arg 495 ate ate gte atg Ile Ile Val Met gao tee Asp Ser 500 gga qaa ate Gly Giu Ile gge ega tat Gly Arg Tyr 520 gaa tot gga ac Giu Ser Gly Thr gaa gag ett ega Giu Giu Leu Arg geg ate gge Ala Ile Giy 515 taattagcca 1651 1700 gaa caa ctg tgg Giu Gin Leu Trp aet Thr 525 geg tgg tot geg Ala Trp Ser Ala cecaagacea ege171 1713 <210> 344 (211> 530 (212> PRT <213> Corynebacterium glutamicum <400> 344 Val Gly Gly Leu Val Asp Lys Leu Leu Ala Thr Pro Ser Met Arg Asp 1 5 10 Val Val Val Phe Ala Leu Leu Ile Val Ala Gly Gly Val Val Ser Ser 25 Leu Gly Thr Trp Trp Gly Ser Ala Leu Met Ala Arg Ala Leu Glu Pro 40 Ala Ile Ala Gly Leu Arg Giu Asp Val Leu Arg Ala Ala Val Ser Leu 55 Asp Ala Asti Thr Ile Giu Thr Ala Gly Arg Gly Asp Val Ile Ser Arg 70 75 Ilie Ala Asp Asp Ser Arg Giu Val Ser Thr Ala Ala Ser Thr Val Val 90 Pro Leu Met Val Gin Ala Gly Phe Thr Val Val Ile Ser Ala Phe Gly 100 105 110 Met Ala Ala Val Asp Trp Arg Leu Gly Leu Val Gly Leu Val Ala Ile 115 120 125 Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg Ser Gly Pro 130 135 140 Leu Tyr Thr Arg Giu Arg Glu Ala Phe Gly Val Arg Thr Gin Arg Leu 145 150 155 160 Val Gly Ala Val Glu Gly Ala Giu Thr Leu Arg Ala Phe Arq Ala Glu 165 170 175 Asp Thr Giu Leu Lys Ar Ile Asp Ala Ala Ser Gly Giu Ala Arg Asp 180 185 190 Ile Ser Ile Ser Val Phe Arg Phe Leu Thr Trp Ala Phe Ser Arg Asni 195 200 205 Asti Arq Ala Giu Cys Ile Thr Leu Val Leu Ile Leu Giy Thr Gly Phe 210 215 220 Tyr Leu Val Asni Ile Asp Leu Val Thr Val Gly Ala Val Ser Thr Ala 225 230 235 240 Ala Leu Ile Phe His Arg Leu Phe Gly Pro Ile Gly Thr Leu Val Gly 245 250 255 Met Phe Ser Asp Ile Gin Ser Ala Ser Ala Ser Leu Ile Arg Met Val 260 265 270 Gly Val Ile Asti Ala Ala Ser Asni Gin Val Ser Gly Thr Ser Pro Ala 275 280 285 Ser Ala Ser Thr Ala Leu Thr Leu Phe Asp Val Ser His His Tyr His 290 295 300 Thr Ala Pro Val Ile Lys Asn Ala Ser Val Gin Leu Glu Pro Gly Glu 305 310 315 320 His Ile Ala Ile Val Gly Ala Thr Gly Ala Gly Lys Ser Thr Leu Ala 325 330 335 Leu Ile Ala Ala Gly Leu Leu Ser Pro Thr Ser Gly Gin Val Ala Leu 340 345 350 Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu Arg Gin Lys 355 360 365 Ile Ala Met Val Ser Gin Glu Ile His Cys Phe Arg Gly Ser Val Leu 370 375 380 Asp Asn Leu Arg Ile Ala Arg Pro Glu Ala Thr Asp Ala Asp Ile His 385 390 395 400 Ala Val Leu Ala Asp Ile Gly Asp Ser Trp Leu Glu Arg Leu Pro Gin 405 410 415 Gly Ile Asp Thr Ile Val Gly Asp Gly Ala Phe Arg Leu Thr Ser Val 420 425 430 Glu Asn Gin Ile Met Ala Leu Ala Arg Val His Leu Ala Asp Leu Ala 435 440 445 Ile Val Ile Leu Asp Glu Ala Thr Ala Glu Ser Gly Ser Asp His Ala 450 455 460 Lys Gin Leu Glu Asp Ala Ala Leu Lys Val Thr Glu Asn Arg Ser Ala 465 470 475 480 Ile Ile Val Ala His Arg Leu Asn Gin Ala Lys Thr Ala Asp Arg Ile 485 490 495 Ile Val Met Asp Ser Gly Glu Ile Ile Glu Ser Gly Thr His Glu Glu 500 505 510 Leu Arg Ala Ile Gly Gly Arg Tyr Glu Gin Leu Trp Thr Ala Trp Ser 515 520 525 Ala Arg 530 <210> 345 <211> 1430 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1)..(1407) <223> FRXA01191 <400> 345 gtg agt ttg gat gcg aac acg att gaa acg gcg ggg cgc ggc gac gtg 48 Val Ser Leu Asp Ala Asn Thr Ile Glu Thr Ala Gly Arg Gly Asp Val att tcg cgt Ile Ser Arg acc gtg gtg Thr Val Val. atc Ile gog gat gat tog Ala Asp Asp Ser gag gtg tcc act Giu Val Ser Thr gog gog agc Ala Ala Ser gtg att tco Val Ile Ser cog otg atg gtg Pro Leu Met Val gog ggo ttt aoo Ala Gly Phe Thr gog ttt Ala Phe ggo atg gcg gog Gly Met Ala Ala gtt Val 55 gat tgg ogo oto Asp Trp Arg Leu gg o Gly ott gto ggt ttg Leu Val Gly Leu gto Val1 gog ato cog otg Ala Ilie Pro Leu tgg aoo aog ttg Trp Thr Thr Leu gto tat tta 000 Val Tyr Leu Pro ogo Arg toa qgt oog ctt Ser Gly Pro Leu tat Tyr aog cgt gag ogo Thr Arg Giu Arg gag Glu 90 goc ttt ggg gtg Ala Phe Gly Val ogo acg Arg Thr cag cqg ott Gin Arg LeU ogo goa gaa Arg Ala Giu 115 ggo gca gto gaa Gly Ala Val Giu gog gaa aoo ttg Ala Giu Thr Leu ogo got tto Arg Ala Phe 110 too ggo gaa Ser Gly Glu gat aoa gaa tta Asp Thr Giu Leu aag Lys 120 ogt ato gao goa Arg Ile Asp Ala goc cgc Ala Arg 130 gac; att too att Asp Ile Ser Ile gtt tto agg ttc Val Phe Arg Phe oto Le u 140 aoa tgg goa ttt Thr Trp Ala Phe ogo aac aac ogo Arg Asn Asn Arg gaa tgo ato aco Giu Cys Ile Thr gtg oto ato ttg Val Leu Ile Leu gg o Gly 160 aco ggo ttt tao Thr Giy Phe Tyr ot g Le u 165 gto aao ato gat Val Asn Ile Asp otg Leu 170 gto aoo gto ggo Val Thr Val Gly goa gto Ala Val 175 toa aoc gc Ser Thr Ala oto gtg ggc Leu Val Gly 195) goa Al a 180 otg ato tto cac Leu Ile Phe His oto ttc ggt oca Leu Phe Gly Pro ato ggc acg Ile Gly Thr 190 tog otg ato Ser Leu Ile 576 624 atg tto too gao Met Phe Ser Asp oaa too qoc ago Gin Ser Ala Ser ogo atg Arg Met 210 gtg ggo gtt att Val Gly Val Ile aac As n 215 gog goa tog aao Ala Ala Ser Asn oag Gin 220 gtc ago ggo aoo Val Ser Gly Thr tog Ser 225 ccg gog tot gc Pro Ala Ser Ala ago Ser 230 aoo got tta aog Thr Ala Leu Thr tto gao gto too Phe Asp Val Ser 672 720 768 oao tat cac act His Tyr His Thr gca Al a 245 000 gto ato aag Pro Val Ile Lys aat Asn 250 goa too gtg oag Ala Ser Val Gin otg gaa Leu Giu 255 cca ggg gaa Pro Gly Giu acg etc gcc Thr Leu Ala 275 atc gcc att gtg Ile Ala Ile Val gcg ace ggc get Ala Thr Gly Ala ggt aaa agc Gly Lys Ser 270 tcc ggg cag Ser Gly Gin 816 864 etc att geg gca Leu Ile Ala Ala ctg etc age eca Leu Leu Ser Pro act Thr 285 gtg gct Val Ala 290 ctc ggc gga teg Leu Gly Giy Ser agt Ser 295 ttt tct aac gte Phe Ser Asn Val ceg gaa gca ttg Pro Glu Ala Leu cag aag ate gcg Gin Lys Ile Ala gte age eaa gaa Val Ser Gin Glu cac tgc tte ega His Cys Phe Arg 912 960 1008 tet gtt tta gat Ser Val Leu Asp aat As n 325 ctt egt ate gca Leu Arg Ile Ala cge Arg 330 ccc gaa gee ace Pro Giu Ala Thr gat geg Asp Ala 335 gac ate eac Asp Ile His tta ceg caa Leu Pro Gin 355 gtt cte gee gat Val Leu Ala Asp ggt gat tee tgg Giy Asp Ser Trp ttg gag cgc Leu Glu Arg 350 ttc egt tta Phe Arg Leu 1056 1104 ggc ata gac ac Gly Ile Asp Thr gtg ggt gat gge Val Gly Asp Gly gct Ala 365 ace tet Thr Ser 370 gtg gaa aae cag Val Giu Asn Gin ate Ile 375 atg geg ctt get Met Ala Leu Ala gta cat ttg gee Val His Leu Ala eta gca ate gte Leu Ala Ile Val ctt gat gaa gca Leu Asp Giu Ala get gaa tea gge Ala Giu Ser Gly 1152 1200 1248 gat cat gca aaa Asp His Ala Lys eag Gin 405 ett gaa gat gca Leu Glu Asp Ala gee Al a 410 ctt aaa gte act Leu Lys Val Thr gaa aac Giu Asn 415 aga tea gcc Arg Ser Ala gat ege ate Asp Arg Ile 435 ate gtg get cac Ile Val Ala His ege Arg 425 etc aae eaa geg Leu Asn Gin Ala aaa ace gee Lys Thr Ala 430 tet gga ace Ser Gly Thr 1296 1344 ate gte atg gac Ile Val Met Asp gga gaa ate ata Gly Gu Ile Ile cat gaa His Glu 450 gag ctt ega geg Giu Leu Arg Ala ate Ile 455 ggc ggt ega tat Gly Gly Arg Tyr gaa Giu 460 caa ctg tgg act Gin Leu Trp Thr 1392 tgg tct geg ege Trp Ser Ala Arg taattagcea cceaagaeea ege 1430 <210> 346 <211> 469 <212> PRT <213> Corynebacterium giutamicun <400> 346 Val Ser Len Asp Ala Asn 1 Ile Thr Al a ValI Ser Gin Arg Ala Ser 145 Thr Ser Leu Arg Ser 225 His Pro Thr Val1 Arg Ser Vali Ph e Al a Gi y Arg Al a Arg 130 Arg Gly Thr Val Met 210 Pro Tyr Gly Le u Ala 290 Gin Arg Va l Gly Ile Pro Leu Glu 115 Asp Asn Phe Al a Gly 195 Val Al a His Glu Al a 275 Leu Lys Ile Pro Met Pro Le u Val1 100 Asp Ile Asn Tyr Al a 180 Met Gly Ser Thr His 260 Leu Gly Ile 5 Al a Le u Al a Len Tyr Gly Th r Se r Arg Le u 165 Leu Phe Val1 Ala Ala 245 Ile Ile ci y Al a Asp Met Ala Tyr 70 Thr Ala Gl1u Ile Ala 150 Val1 Ile Se r Ile Ser 230 Pro Aia Ala Ser Met Thr Asp Val1 Val1 55 Trp Arg Val1 Leu Ser 135 Glu As n Phe Asp Asn 215 Thr Val1 Ile Ala Ser 295 Val1 Ile Giu Thr Ala Gly Arg Gly Asp Val Ser Gin 40 Asp Thr Glu Glu L ys 120 Val1 Cys Ile His Ile 200 Al a Al a Ile Val1 Gly 280 Phe Se r Arg 25 Ala Trp Thr Arg Gly 105 Arg Phe Ile Asp Arg 185 Gln Ala Len Lys Gly 265 Leu Ser Gln 10 Gin Gly Arg Le u Giu 90 Aia Ile Arg Thr Le u 170 Leu Ser Ser Thr As n 250 Al a Len As n Glu Val1 Phe Le u Ar g 75 Al a Gin Asp Phe Len 155 Val1 Phe Al a As n Leu 235 Al a Thr Ser Val1 Ile Ser Thr Gly ValI Phe Thr Ala Len 140 Val Thr Gly Ser Gin 220 Phe Ser Gly Pro Glu 300 His Thr Val1 Le u Tyr Gi y Len Ala 125 Th r Leu Val Pro Ala 205 Val1 Asp Val1 Ala Thr 285 Pro Cys Ala Val1 Val1 Len Val1 Arg 110 Ser Trp Ile Gly Ile 190 Ser Ser Val1 Gin Gly 270 Ser Gin Phe Al a Ile Gly Pro Arq Ala Gly Ala Len Al a 175 Gly Len Gly Ser Len 255 Lys Gly Ala Arg Ser Ser Leu Ar g Th r Ph e Glu Phe Gly 160 Val1 Thr Ile Thr His 240 Gin Ser Gin Len Gly 305 Ser Val Leu Asp Ile His Leu Pro Gin 355 Thr Ser Va.l 370 Asp Leu Ala 385 Asp His Ala Arq Ser Ala Asp Ar Ile 435 His Glu Giu 450 Ala Trp Ser 465 <210> 347 (211> 1047 <212> DNA Asp Ala 340 Gly Glu Ile Lys Ile 420 Ile Le u Ala Asn 325 Val Ile As n Val1 Gln 405 Ile Val1 Ar q Arg 310 Leu Le u Asp Gin Ile 390 Leu Val1 Met Ala Ile Asp Ile 360 Met Asp Asp His Ser 440 Giy Arg 330 Gly Giy Leu Al a Al a 410 Leu Glu Arg Glu Ser Gly Arg 380 Ala Lys Gin Ile Giu 460 Al a Trp Ala 365 ValI Glu Val1 Al a Giu 445 Gin Asp 335 Glu Arg Leu Gly Giu 415 Thr Gly Trp 320 Al a Arg Leu Al a Se r 400 As n Al a Thr Thr <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1024) <223> RXN01212 <400> 347 tttagaagcc acatgacata tgtcatgaaa attatgtgca catatggctc taccagcgcc aatgcgaagt aqgaagaatt aca Thr acc Thr gg t Gly cca Pro gca Ala ctg Le u gca Ala gtc Vai ctc Le u gac Asp gqC Gly acc Thr aca Thr aat Asn qgg Gly gac Asp ttc Phe gcc Ala 45 gtg ValI 15 gta ValI aaa Lys aagtgcagta atactcctga atg cct atg aca acg Met Pro Met Thr Thr 1 acc tac ggc gac tac Thr Tyr Gly Asp Tyr cgc ggt gaa gta ttt Arg Gly Giu Val Phe tcc acc ttg gaa gte Ser Thr Leu Giu Val 115 163 211 259 atc gaa Ile Glu gga ctt tcc gca Gly Leu Ser Ala ago tcc ggc acc Ser Ser Gly Thr cgc atc tcc ggg Arg Ile Ser Gly ott Leu gac ccc gtt 900 Asp Pro Val Ala ogc gcg atc ctg Arg Ala Ile Leu cgc Arg ccc gag cto ggc Pro Giu Leu Gly atg ctg caa tca Met Leu Gin Ser gg0 Gly ggc ctg cca tca Gly Leu Pro Ser ctc acc gtc gcc Leu Thr Val Ala gaa ac Glu Thr 100 atg gac atql Met Asp Met: gtg ott gcc Val Leu Ala 120C t gg Trp 105 cac ggc acc tqc His Gly Thr Cys a cg Thr 110 tat ccg cgc gcc Tyr Pro Arg Ala att aaa gat Ile Lys Asp 115 aag gtc ggc Lys Val Gly 451 499 gac gto gac ctc Asp Val Asp Leu cac cgc gaa aac His Arg Giu Asn gcg ctt Ala Leu 135 tcc: gga ggo gaa Ser: Gly Gly Glu cga cgc ctt gat Arg Arg Leu Asp ttg Leu 145 qoc tgc gca ctg Ala Cys Ala Leu ggc gac ccc tca. Gly Asp Pro Ser att Ile 155 ttg ttc ctc gac Leu Phe Leu Asp coo acc acc ggc Pro Thr Thr Gly 547 595 643 gac cca gaa tct Asp Pro Glu Ser ogc cac acc tgg Arg His Thr Trp ctc ctg ctg gac Leu Leu Leu Asp ctg aaa Leu Lys 180 cag cgc ggc Gin Arg Gly gaa ttc ctc Giu Phe Leu 200 gt o Val1 185 acc atg atg ctg Thr Met Met Leu acc Thr 190 acc cac tao ctg Thr His Tyr Leu gag gaa gc Giu Giu Ala 195 gag atc gca Glu Ile Ala tgc gac cgg att Cys Asp Arg Ile atc atg aac 9CC Ile Met Asn Ala gtg gaa Val Giu 215 ggc acc ttg gat Gly Thr Leu Asp ctg gtg 900 090 Leu Val Ala Arg aag tog atc ato Lys Ser Ile Ile ttc gtgj ctg ogt Phe Val Leu Arg ggc Gly 235 ggg cag gtg gag Gly Gin Val Giu ttg Leu 240 cog gtc ttg agt Pro Val Leu Ser ggg Gly 245 got gaa atc atc Ala Gu Ile Ile gao aao aao cao Asp Asn Asn His 090 ato 900 acc Arg Ile Ala Thr aoo aoo Thr Thr 260 otg oag oag Leu Gin Gin ato 909 ctg Ile Ala Leu 280 oao His 265 aco tta gaa ata Thr Leu Giu Ile ott Leu 270 aco tgg got gos Thr Trp Ala Ala gag aoo 999 Giu Thr Gly 275 gaa too gta Glu Ser Val gaa 990 tto got Giu Gly Phe Ala aaa 000 900 aoo Lys Pro Ala Thr ttg Leu 290 ttc atg cjac atc gcc tca ctc gag aac acc tcg ctg caa acc gcc 1024 Phe Met Asp Ile Ala Ser Leu Glu Asn Thr Ser Leu Gin Thr Ala 295 300 305 tagaatcttt aaggagacca caa 1047 (210> 348 <211> 308 <212> PRT <213> Corynebacterium glutamicum <400> 348 Met Pro Met Thr Thr Thr Pro Ala Ile Asp Val Thr Asp Leu Val Arg 1 5 10 Thr Tyr Gly Asp Tyr Thr Ala Val Lys Gly Leu Asn Phe His Vai Gin 25 Arg Gly Giu Val Phe Gly Leu Leu Gly Thr Asn Gly Ala Gly Lys Thr 40 Ser Thr Leu Giu Val Ile Glu Gly Leu Ser Ala Pro Ser Ser Gly Thr 55 Val Arg Ile Ser Gly Leu Asp Pro Val Ala Asp Arg Ala Ile Leu Arg 70 75 Pro Glu Leu Gly Ile Met Leu Gin Ser Gly Gly Leu Pro Ser Gin Leu 90 Thr Val Ala Giu Thr Met Asp Met Trp His Gly Thr Cys Thr Tyr Pro 100 105 110 Arg Ala Ile Lys Asp Val Leu Ala Asp Val Asp Leu Leu His Arg Glu 115 120 125 Asn Val Lys Val Gly Ala Leu Ser Gly Gly Giu Gin Arg Arg Leu Asp 130 135 140 Leu Ala Cys Ala Leu Leu Gly Asp Pro Ser Ile Leu Phe Leu Asp Giu 145 150 155 160 Pro Thr Thr Gly Leu Asp Pro Giu Ser Arg Arg His Thr Trp Gin Leu 165 170 175 Leu Leu Asp Leu Lys Gin Arq Gly Val Thr Met Met Leu Thr Thr His 180 185 190 Tyr Leu Giu Giu Ala Glu Phe Leu Cys Asp Arg Ile Ala Ile Met Asn 195 200 205 Ala Gly Giu Ile Ala Val Giu Gly Thr Leu Asp Glu Leu Val Ala Arg 210 215 220 Glu Lys Ser Ile Ile Ser Phe Val Leu Arg Giy Gly Gln Val Glu Leu 225 230 235 240 Pro Val Leu Ser Gly Ala Giu Ile Ile Arg Asp Asn Asn His Vai Arg 245 250 255 Ile Ala Thi: Thr Thr Leu Gin Gin His 260 265 Ala Ala GiU Thr Gly Ile Ala Leu Glu 275 280 Thr Leu Glu Ile Leu Thr Trp 270 Lys Pro Ala Gly Phe Ala Thr Leu Glu Ser Val Phe Met Asp Ile Ala Ser Leu 290 295 300 Glu Asn Thr Ser Leu Gin Thr Aia 305 <210> 349 <211> 813 <212> DNA <213> Corynebacterium giutamioum <220> <221> CDS <222>' (813) <223> FRXA01212 <400> 349 ggc ctg aat ttc cat Gly Leu Asn Phe His 1 5 gta cag cgc ggt Vai Gin Arq Gly gta ttt ggt ctg Val Phe Gly Leu oto ggc Leu Gly acc aac ggg Thr Asn Giy tcc gca ccc Ser Ala Pro gc Al a ggc aaa acc too Gly Lys Thr Ser ttg gaa. gtc ato Leu Giu Val Ile gaa gga ott Giu Giy Leu gac coo gtt Asp Pro Val ago tcc ggo acc Ser Ser Gly Thr gtg Val ogo ato too ggg Arg Ile Ser Gly gcc gao Ala Asp cgc gcg atc ctg Arg Ala Ile Leu ccc gag ctc ggc Pro Giu Leu Gly atg ctq caa tca Met Leu Gin Ser ggc Giy ggc ctg oca tca Gly Leu Pro Ser cag Gin 70 ctc acc gto gcc Leu Thr Val Ala gaa Glu acc atg qac atg Thr Met Asp Met cac ggo acc tgc His Gly Thr Cys tat cog cgc cc Tyr Pro Arg Ala aaa gat gtg ott Lys Asp Val Leu gcc gao Ala Asp gtc gao otc Val Asp Leu ggc gaa caa Gly Glu Gin 115 cta Le u 100 oao ogo gaa aac His Arg Glu Asn aag gtc gqc gcg Lys Val Gly Ala ott tcc gga Leu Ser Gly 110 ggc qac ccc Gly Asp Pro 336 384 oga cgc ctt gat Arg Arg Leu Asp t tg Leu 120 goc tqo gca ctg Ala Cys Ala Leu ott Le u 125 toa att Ser Ile 130 ttgj ttc oto gao Leu Phe Leu Asp coo aco aco ggc Pro Thr Thr Gly gao cca gaa tct Asp Pro Glu Ser agg cgc cac aco tgg caa oto otg ctg gao ctg aaa cag ogo ggc gtc Arg 145 acc Thr gac Asp ttg Leu cqt Arg cgc Arq 225 acc Thr ggC Gly Arg His Thr Trp Gin Leu Leu Leu Asp Leu Lys Gin Arg Gly Val atg Met cgg Arg ga t Asp ggc Gly 210 gac Asp tta Le u ttc Phe atg Met: a t t: I I E gaa Gl1U 195 ggcj Gly a a c Asrn gaa Gl1u gct Al a ctg Leu gcc Ala 180 ctg Leu cag Gin aac Asn ata Ile g ca Ala 260 150 acc Th r atg Met gcc Al a gag Gi u qtc Val1 230 acc Thr ccc Pro cac His aac Asn cgc Arg t tg Leu 215 cgc Arg t gg Trp gcc Ala tac Tyr gcc Al a gag Giu 200 ccg Pro at c Ile gct Al a acc Thr ctg Le u ggt Gi y 185 aag Lys gtc Val1 gcc Al a gca Ala ttg Le u 265 gag Giu 170 gag Giu tcg Ser ttg Leu acc Th r gag Glu 250 gaa Glu Glu 10 Leu Ile Leu Ala Ile 90 Lys Cys 155 ga a Giu atc Ile atc Ile agt Se r acc Thr 235 acc Thr tcc Ser Val1 Giu Ser Gly Giu 75 Lys Val1 Ala gcc Al a gca Ala atc Ile ggg Gi y 220 acc Thr ggg Gly gta Val1 Phe Val Gly Ile Thr As p Gly Le u ttc Phe gaa Glu 190 ttc Phe gaa Giu cag Gin gcg Al a atg Met 270 Le u Glu Asp Leu Asp Leu Leu 110 Gly Ctc Leu 175 ggc Gly gtg Val1 atc Ile cag Gin ctg Leu 255 ga c Asp Le u Gly Pro Gin Met Ala Se r Asp 528 576 624 672 720 768 813 (210> 350 <211> 271 <212> PRT (213> Coryriebacterium giutamicum (400> 350 Gly Leu Asn Phe His Val Gin Arg Gly 1 5 Thr Asn Gly Ala Gly Lys Thr Ser Thr 25 Ser Ala Pro Ser Ser Gly Thr Val Arg Ala Asp Arg Ala Ile Leu Arg Pro Glu 55 Gly Gly Leu Pro Ser Gin Leu Thr Val 70 His Gly Thr Cys Thr Tyr Pro Arg Ala Val Asp LeU Leu His Arg Gin Asn Val 100 105 Gly Gin Gin Arg Arg Len Asp Leu Ala 115 120 Gly Len Val1 Ser T rp, Asp Gly Pro Se r Arg 145 Thr Asp Leu Arq Arg 225 Thr Gly Ile 130 Arg Met Arg Asp Gi y 210 Asp Leu Phe Phe Thr Len Ala 180 Len Gin Asn Ile Ala 260 Len Trp Thr 165 Ile Val1 Val1 His Leu 245 Lys Asp Gin 150 Thr Met Ala Glu Val 230 Thr Pro Giu 135 Le u His Asn Arg Leu 215 Arg Trp Ala Thr Leu Leu Giy 185 Lys Val1 Ala Al a Leu 265 Thr Asp Gin 170 Gin Ser Leu Thr Giu 250 Glu Gly Leu 155 Gin Ile Ile Ser Thr 235 Thr Ser Le u 140 Lys Al a Al a Ile Giy 220 Thr Gi y Val1 Asp Gin Glu Val1 Se r 205 Al a Le u Ile Phe Gin Gly Leu 175 Giy Val1 Ile Gin Leu 255 Asp Ser Val1 160 Gys Thr Leu Ile His 240 Giu <210> 351 <211> 999 (212> DNA <213> Corynebacterium giutamicun <220> <221> CDS <222> (101)..(976) <223> RXA02749 <400> 351 caacctaqac ttcggtaaga agtaactttg ctttagttgg agcqatgcgc cgattacttq tttttgctac aaatttaact aaa Lys ggt Gly gag Gin ga t Asp gt g Val1 tta Len aac Asn caa Gin ga c Asp ttt Phe gca Ala acc Thr gtc Val1 gtt Val1 aaa Lys gqg Giy aaa Lys t ca Ser a ca Thr gag Gin 60 tat Tyr ggg Giy 30 a cg Thr gaa Gin qgC Gi y gaa Gin att Ile ctq Len tcggcgcatc actttcccta atg tca ccc atc cta Met Ser Pro Ile Len 1 acc gtt geg gtt gac Thr Val Ala Val Asp ttt gcc ttt cta ggg Phe Ala Phe Leu Gly tgc ctq att ggc att Cys Len Ile Giy Ile ggt ggc caa gta ga~t Gly Giy Gin Val Asp 115 163 211 259 307 t ct Ser gaa aaa ctt gga Giu Lys Leu Gly gtg Val1 75 gtg ttt caa caa Val Phe Gin Gin t cc Ser gtc tta gac cct Val Leu Asp Pro 355 403 ctg agt gcc aaa Leu Ser Ala Lys aac ttg gaa aca Asn Leu Glu Thr cgc Arg gga cag ctg tac Gly Gin Leu Tyr cca ggg Pro Gly 100 gtg ggg aag Val Gly Lys ggg ttt gcq Gly Phe Ala 120 cag Gin 105 cgg gtt gca cag Arg Val Ala Gin att gag caa atc Ile Giu Gin Ile ggg atg gaa Gly Met Glu 115 gaa aaa cgt Giu Lys Arg gac cgc cga tac Asp Arq Arg Tyr gg a Giy 125 gtg ttg tcg ggc Val Leu Ser Gly cgc acc Arg Thr 135 gac atc gca cga Asp Ile Ala Arg tta ctg cac agc Leu Leu His Ser cca Pro 145 qac att ctt ttt Asp Ile Leu Phe ctt Leu 150 gat gaa ccc aca Asp Giu Pro Thr ggc ctc gac ccc Giy Leu Asp Pro tca cga cgc caa Ser Arg Arg Gin gt t ValI 165 tgq gac acc atc Trp Asp Thr Ilie aa t As n 170 tcc ctg cgt aac Ser Leu Arg Asn gat Asp 175 gtg ggc ctc act Val Gly Leu Thr gtc ttt Val Phe 180 ttg acc act: Leu Thr Thr atc att gac Ile Ile Asp 200 tac atg gaa gaa Tyr Met Giu Glu gaa ctg gct gat Giu Leu Ala Asp tca gtt cta Ser Vai Leu 195 atg gaa ctg Met Giu Leu cgt ggc aaa gag Arg Gly Lys Giu gtc Val1 205 gca tca gga acc Ala Ser Gly Thr ccq Pro 210 cgc gcc Arg Ala 215 cgt tac acc aca Arg Tyr Thr Thr gaa ttg act ctt Glu Leu Thr Leu aca aac gac cct Thr Asn Asp Pro act Thr 230 cat tcg ggt aaa His Ser Gly Lys gag Glu 235 ttg gcc cac ttg Leu Ala His Leu agc Ser 240 cca gaa atc qac Pro Giu Ile Asp gac cga ctq cgg Asp Arg Leu Arg atc Ile 250 aag ttg gaa aat Lys Leu Giu Asn ggg Gly 255 ctc gaa gct gcg Leu Giu Ala Ala cgc ctg Arg Leu 260 gca aca gaa Ala Thr Glu atg gac gat Met Asp Asp 280 gat ggg gtt ctc Asp Gly Val Leu gac Asp 270 gta gag atc cgc Val Giu Ile Arg cac ggt tcc His Gly Ser 275 gta ttt cta gca Val Phe Leu Ala aca gct gaa cgg Thr Ala Giu Arg aaa cga tca Lys Arg Ser 290 tgattacagt tctgacacgc aga <210> 352 <211> 292 <212> PRT <213> Corynebacterium glutamicum <400> 352 Met Ser Pro Ile Leu Lys Val Arg Asp Leu Val Lys Arg Tyr Gly Asp 1 5 10 Thr Val Ala Val Asp Gly Leu Asn Phe Asp Val Ser Gin Gly Glu Ile 25 Phe Ala Phe Leu Gly Glu Asn Gly Ala Gly Lys Thr Thr Thr Ile Ser 40 Cys Leu Ile Gly Ile Asp Gin Ala Thr Ser Gly Glu Ile Glu Leu Gin 55 Gly Gly Gin Val Asp Ser Glu Lys Leu Gly Val Val Phe Gin Gin Ser 70 75 Val Leu Asp Pro Leu Leu Ser Ala Lys Glu Asn Leu Glu Thr Arg Gly 90 Gin Leu Tyr Pro Gly Val Gly Lys Gin Arg Val Ala Gin Leu Ile Glu 100 105 110 Gin Ile Gly Met Glu Gly Phe Ala Asp Arg Arg Tyr Gly Val Leu Ser 115 120 125 Gly Gly Glu Lys Arg Arg Thr Asp Ile Ala Arg Ala Leu Leu His Ser 130 135 140 Pro Asp Ile Leu Phe Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Arg 145 150 155 160 Ser Arg Arg Gin Val Trp Asp Thr Ile Asn Ser Leu Arg Asn Asp Val 165 170 175 Gly Leu Thr Val Phe Leu Thr Thr His Tyr Met Glu Glu Thr Glu Leu 180 185 190 Ala Asp Ser Val Leu Ile Ile Asp Arg Gly Lys Glu Val Ala Ser Gly 195 200 205 Thr Pro Met Glu Leu Arg Ala Arg Tyr Thr Thr Thr Glu Leu Thr Leu 210 215 220 Arg Thr Asn Asp Pro Thr His Ser Gly Lys Glu Leu Ala His Leu Ser 225 230 235 240 Pro Glu Ile Asp Gly Asp Arg Leu Arg Ile Lys Leu Glu Asn Gly Leu 245 250 255 Glu Ala Ala Arg Leu Ala Thr Glu Leu Asp Gly Val Leu Asp Val Glu 260 265 270 Ile Arg His Gly Ser Met Asp Asp Val Phe Leu Ala Val Thr Ala Glu 275 280 285 Arg Lys Arg Ser 290 <210> <211> <212> <213> <220> <221> <222> <223> 353 1920 DNA Corynebacterium giutamicum CDS (1897) RXA02 224 <400> 353 gettcgtcga ggccggaaaa ccgtcgteat tacgtcqaac aaagcagatg caatetgatt tttcggaagg ggtgaagtag ccgacgtggc acggcgtcgc atg Met 1 gcg cag eat Ala Gin His cge gtt gcg gat Arg Val Ala Asp etg cag ecg geg tcg ttg gcg gag tcg Leu Gin Pro Ala Ser Leu Ala Giu Ser tgg cgt Trp Arg gag ctg aaa Glu Leu Lys ttc gtg gtt Phe Val Val a cg Thr atg cct teg ggg Met Pro Ser Gly aaq gcc tqg tgq Lys Ala Trp Trp tat gq agt Tyr Val Ser ggc acg tcc Gly Thr Ser 211 259 att age gtg gtc Ile Ser Val Val acg Thr gte gtg gcg atg Val Val Ala Met aac ttg Asn Leu ttg ggc tat tee Leu Gly Tyr Ser gat ctg ate aat Asp Leu Ile Asn ggg Gly eag teg ttg eeg Gin Ser Leu Pro etg Leu ate ggt tea gga Ile Gly Ser Gly t cg Ser aee gca atg ate Thr Ala Met Ile ttg ett ggt ttg Leu Leu Gly Leu gge get gga att Giy Ala Gly Ile gea gaa act gee Ala Giu Thr Ala ege gcg etg etg Arg Ala Leu Leu eaa ttg Gin Leu 100 gtg ate aac Val Ile Asn geg etg tet Ala Leu Ser 120 ace T hr 105 ttg gca egt ego Leu Ala Arg Arg teg gig gat ctg Ser Val Asp Leu egg aaa get Arg Lys Ala 115 atg gaa ttg Met Giu Leu teg geg ttg egt Ser Ala Leu Arg gca Ala 125 ceg gtt eet gat Pro Val Pro Asp ggc aeg Gly Thr 135 gga aac gtg att Gly Asn Val Ile ege ctg acg eaa Arg Leu Thr Gin gac Asp 145 ate gat aac act Ile Asp Asn Thr gtg Val1 150 ege ate gte gge Arg Ile Val Gly atg Met 155 gta ggt gtg egt Val Gly Val Arg gtg ate ace att Val Ile Thr Ile ttg Le u 165 att etg ccc age tee ttg te gcg ttg atg ace att cac tgg aec ttt Ile Leu Pro Ser Ser Leu Phe Ala Leu Met Thr Ile His Trp Thr Phe gtg atc ctgj Val Ile Leti aaa gce gtcj Lys Ala Val 200C atc gca gtg att Ile Ala Val Ile gtg ctg att ccc Val Leu Ile Pro age ggt egg Ser Gly Arg 195 tcc agt acg Ser Ser Thr cga gct att cct Arg Aia Ile Pro gca aca aat att Ala Thr Asn Ile gag geg Giu Ala 215 cgt: ega aac aat Arc; Arg Asn Asn ctg. etc Leu Leu 220 ctc gat aeg Leu Asp Thr atc Ile 225 cgt ggc att gaa Arg Gly Ile Giu ctg egt gtg etc Leu Arg Val Leu aag Lys 235 etc ggt gcg tgg Leu Giy Ala Trp gg t Gly 240 gtg cag egg atg Val Gin Arg Met ege Ar g 245 caa geg teql tgg Gin Ala Ser Trp geg gtg caa gca Ala Vai Gin Ala get gat ege geg Ala Asp Arg Ala ceg att Pro Ile 260 ttc aet egt Phe Thr Arc; att ggc qtcl Ile Gly Val. 280 ctg Leu 265 etc gee ett ggt Leu Ala Leu Gly teg Se r 270 att get tat gge Ile Ala Tyr Gly ctg ctg eta Leu Leu Leu 275 gat geg atg Asp Ala Met ttt qgg etc agt Phe Gly Leu Ser gcg Al a 285 ttt tgg gtt gee Phe Trp Val Ala cag Gin 290 age att Ser Ile 295 gga geg gea aeg Gly Aia Ala Thr gca gtt tte gtg Ala Vai Phe Vai gtt Val 305 gtg cgc atg gaa Val Arg Met Giu att Ile 310 eac gtcl tte a-ae His Val Phe Asn gt g Val1 315 ctg ttc tte gea Leu Phe Phe Ala gaa att eag agt Giu Ile Gin Ser tet act tct: ctt Ser Thr Ser Leu ege geg gtg tee Arg Ala Vai Ser gee eag atg get Ala Gin Met Ala egt ege Arg Arg 340 1027 1075 1123 1171 1219 ace gaa caq Thr Giu Gli act gtg cag Thr Val Gin 360 etg Leu 345 tet gag tet gee Ser Giu Ser Ala ga t Asp 350 tge aca gaa eca Cys Thr Glu Pro ccc tee gtg Pro Ser Val 355 gee att ttg Ala Ile Leu gac gtg aeg ttt Asp Vai Thr Phe tat ccc ggc ggc Tyr Pro Gly Gly gag gat Giu Asp 3-75 ttc: aat etg gte Phe Asn Leu Val gaa gea gga aea Giu Ala Gly Thr aca geg etg gte Thr Ala Leu Val ggt Gly 390 act tet ggt geg Thr Seir Gly Ala gga Gly 395 aaa tee aeg etc Lys Ser Thr Leu ggc gte att geg Gly Val Ile Ala 1267 1315 1363 ctg cag ege eet Leu Gin Arg Pro tce gge gee gtt Ser Gly Ala Vai ttg Le u 415 gtc ggg ggc ate Val Gly Gly Ile aac ace Asn Thr 420 gcc acc gte Ala Thr Val cag gaa gte Gin Glu Val. 440C ac Thr 25 gac acg tgq act Asp Thr Trp Thr ace Thr 430 cgc eag gtt gcg Arg Gin Val. Ala ctg atc age Leu Ile Ser 435 ctt cgc atg Leu Arg Met 1411 1459 cac ctt ttc gca His Leu Phe Ala act ctg gca gag Thr Leu Ala Glu gcc aat Ala Asn 455 gcg cac gcc acc Ala His Ala Thr gac Asp 460 gcg cag ctc cac Ala Gin Leu His gca gcg cte gag tcg Ala Ala Leu Giu Ser 465 cgt ttc ttt eca tc Arg Phe Phe Pro Ser ggg ctc ggg caa Gly Leu Gly Gin atg aca Met Thr 475 act get ttt Thr Ala Phe 1507 1555 1603 gga tta gac acc Gly Leu Asp Thr att ggc gcc ggc Ile Gly Ala Gly gaa gaa etc ace Glu Giu Leu Thr cet gaa Pro Giu 500 ate caa cag Ile Gin Gin gtg ttg atc Val Leu Ile 520 caa Gin 505 ate tet ett gee Ile Ser Leu Ala ege Arg 510 ate gtg etc ege Ile Val Leu Arg aat eca ect Asn Pro Pro 515 gat gat gee Asp Asp Ala 1651 1699 atg gat gaa gee Met Asp Glu Ala agt gaa gee gge Ser Giu Ala Gly ege atg Arq Met 535 ttgj gaa aaa gee Leu Giu Lys Ala aca gaa ate gea Thr Glu Ile Ala eg a Arg 545 aae ege ace ace Asn Arg Thr Thr ttg Leu' 550 gtt gtt geg cac Val Val Ala His ege Arg 555 ett gac caa gca Leu Asp Gin Ala gte gea gat ege Val. Ala Asp Arq 1747 1795 1843 1891 ate gtg atg qaa Ile Val Met Glu gge aca ate ace Gly Thr Ile Thr gac gge act cac Asp Gly Thr His cag gaa Gin Glu 580 tta ett get Leu Leu Ala gag gge ege tac Glu Gly Arg Tyr cag etg tat eaa Gin Leu Tyr Gin ega tgg aqt Arg Trp Ser 595 get caa Ala Gin tagttcaaat ccaceaeaaa etc 1920 <210> 354 <211> 599 <212> PRT <213> Corynebacterium giutamicum <400> 354 Met Ala Gin His Glu Arg Val. Ala Asp Ala Leu Gin Pro Ala Ser Leu 1 5 10 Ala Glu Ser Trp Arg Glu Leu Lys Thr Met Pro Ser Gly Pro Lys Ala 25 Trp Met Gly Leu Ala Asp Asp Asp 145 Val1 Ile Ile Ile Ile 225 Val1 Asp T yr Ala Val1 305 Glu Gin Tyr Gly Se r Gi y Le u Arg 115 Met As p Thr Trp Ser 195 Se r Gly Arq Aila Leu 275 Asp Arg Gin Al a Val1 Thr Le u Leu Gin 100 Lys Gi u As n Ile Th r 180 Gi y Se r Ile Met Pro 260 Leu Al a Met Ser Arg 340 Ser Se r Pro ValI Leu Ala Leu Thr Leu 165 Phe Arg Thr Glu Arg 245 Ile Leu Met Glu Ala 325 Arg Phe As n Leu 70 Gi y ValI Al a Gly Val1 150 Ile Val1 Lys Glu Thr 230 Gin Phe Ile Ser Ile 310 Ser Thr Val1 40 Leu Gly Gly As n Se r 120 Gly Ile Pro Leu Vai 200 Arg Ar g Ser Arg Val1 280 Gi y Val1 Ser Gin Ile Gi y Ser Ile Thr 105 Ser As n Val1 Ser Phe 185 Ar g Arq Val1 Trp Leu 265 Phe Al a Phe Le u Leu 345 ValI Val1 Thr Glu Arg Arg Ser 140 Val1 Phe Val1 Pro Leu 220 Leu Val1 Leu Ser Al a 300 Leu Ala Ser Thr Asp Ala Thr Arg Al a 125 Arg Gly Al a Ile Ser 205 Leu Gly Gin Gly Ala 285 Ala Phe Val1 Ala Val1 Le u Met Al a Leu 110 Pro Le u Val1 Leu Val1 190 Ala Le u Al a Ala Ser 270 Phe Val Phe Ser Asp 350 Val1 Ile Ile Gly Ser Val1 Thr Arg Met 175 Val1 Thr Asp Trp Thr 255 Ile Trp Phe Al a Le u 335 Cys Ala As n Trp Arg Val1 Pro Gin Leu 160 Thr Leu Asn Thr Gly 240 Ala Ala Val1 Val1 Se r 320 Al a Thr Glu Pro Pro Ser Val Thr Val Gin Asp Val Thr Phe Lys Tyr Pro Gly 355 360 365 Gly Val Ala Ile Leu Glu Asp Phe Asn Leu Val Leu Glu Ala Gly Thr 370 375 380 Thr Thr Ala Leu Val Gly Thr Ser Gly Ala Gly Lys Ser Thr Leu Ala 385 390 395 400 Gly Val Ile Ala Gly Leu Gin Arg Pro Asp Ser Gly Ala Val Leu Val 405 410 415 Gly Gly Ile Asn Thr Ala Thr Val Thr Asp Thr Trp Thr Thr Arg Gin 420 425 430 Val Ala Leu Ile Ser Gin Glu Val His Leu Phe Ala Gly Thr Leu Ala 435 440 445 Glu Asp Leu Arg Met Ala Asn Ala His Ala Thr Asp Ala Gin Leu His 450 455 460 Ala Ala Leu Glu Ser Val Gly Leu Gly Gin Met Thr Thr Ala Phe Arg 465 470 475 480 Arg Phe Phe Pro Ser Gly Leu Asp Thr Lys Ile Gly Ala Gly Ala Glu 485 490 495 Glu Leu Thr Pro Glu Ile Gin Gin Gin Ile Ser Leu Ala Arg Ile Val 500 505 510 Leu Arg Asn Pro Pro Val Leu Ile Met Asp Glu Ala Thr Ser Glu Ala 515 520 525 Gly Ser Asp Asp Ala Arg Met Leu Glu Lys Ala Ala Thr Glu Ile Ala 530 535 540 Arg Asn Arg Thr Thr Leu Val Val Ala His Arg Leu Asp Gin Ala Val 545 550 555 560 Val Ala Asp Arg Ile Ile Val Met Glu Gin Gly Thr Ile Thr Glu Asp 565 570 575 Gly Thr His Gin Glu Leu Leu Ala Phe Glu Gly Arg Tyr Ala Gin Leu 580 585 590 Tyr Gin Arg Trp Ser Ala Gin 595 <210> 355 <211> 1653 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1630) <223> RXN01602 <400> 355 tgcaggccac atgcctccca gtgccgtctc tgcacgttga ttttcccctg ccacgactgg tcgcagggcg actttctagc acttttaaag gaatttttta atg gct aaa acc cat Met Ala Lys Thr His att cgg tta cag Ile Arg Leu Gin gac Asp ctt tcc ctg tca Leu Ser Leu Ser tac Tyr 15 acc tca acc ccg Thr Ser Thr Pro tta att Leu Ile acg aag ctc Thr Lys Leu ggt gag aat: Gly Giu Asn atc act gtt tct Ile Thr Val Ser gga cag tgc gca Gly Gin Cys Ala gtg att gtt Val Ile Val ctg gct cga Leu Ala Arg ggt cga ggt aaa Gly Arg Gly Lys acc Thr aca ctt ctg cga Thr Leu Leu Arg gaa ttc Giu Phe ccg cca tct gca Pro Pro Ser Ala ggt Gly gag att ctc act Glu Ile Leu Thr ggc acg gta gca Gly Thr Val Ala gct cat: caa cac Ala His Gin His atg Met cct gca ggt gat Pro Ala Gly Asp tcc gtc gga gag Ser Val Gly Giu atc Ile tgt gat gag gca Cys Asp Glu Ala cgt gat tca aag Arg Asp Ser Lys aa t Asn gct ctc gaa gag Ala Leu Glu Glu ctt gag Leu Glu 100 aga gct gga Arg Ala Gly tat caa caa Tyr Gin Gin 120 cta ctt gag aca Leu Leu Giu Thr act gcg cac gca Thr Ala His Ala ctt gat gga Leu Asp Gly 115 tgg aac gct Trp Asn Ala 451 499 gcc ctt gat gcc Ala Leu Asp Ala gaa gtg ctt gac Glu Val Leu Asp gca Al a 130 gaa cat Giu His 135 cga tta gaa aaa Arg Leu Glu Lys gct Ala 140 ctg cgc agc ttt Leu Arg Ser Phe qgc Gly 145 gcg atc acc gat Ala Ile Thr Asp a ga Arg 150 tcc cgt gca ctc Ser Arg Ala Leu gag cta tcg atc Giu Leu Ser Ile ggg Gly 160 caa agg tat cgg Gin Arg Tyr Arg cgg ctg gcc tgc Arg Leu Ala Cys ctc Le u 170 atc ggt ggc gat Ile Giy Giy Asp gat att ttg ctt Asp Ile Leu Leu ctc gat Leu Asp 180 gaa ccc acc Glu Pro Thr gcc ata acc Ala Ile Thr 200 aa t As n 185 cat ctt gac cgg His Leu Asp Arg gcg ctt aac tat Ala Leu Asn Tyr ctc acc gaa Leu Thr Giu 195 cat gat caa His Asp Gin tcc cac aaa ggt Ser His Lys Gly gtg Val1 205 gta ctt gtt qtt Val Leu Val Val gca ctg Ala Leu 215 atc aaa gat gtc Ile Lys Asp Val gat ttc atc atc Asp Phe Ile Ile att gat tca acc Ile Asp Ser Thr cca Pro 230 gao ggo cta cca Asp Gly Leu Pro ato tat cat gag Ile Tyr His Giu ggt Gly 240 ttt gat tot tat Phe Asp Ser Tyr oga Arg 245 835 883 cgc caa agg agt Arg Gin Arg Ser gcg Al a 250 Ott ott gaa act Leu Leu Glu Thr t gg T rp 255 agg cag gat tat Arg Gin Asp Tyr gco got Ala Ala 260 goa oaa act Ala Gin Thr cag cgg gtq Gin Arg VaL 280 caa cag oaa ttg Gin Gin Gin Leu gag gat ota gag Giu Asp Leu Giu cac gca cgc His Ala Arg 275 gga aaa cac Gly Lys His aat tot tog tgg Asn Ser Ser Trp cot oca aaa gga Pro Pro Lys Gly aot ogo Thr Arg 295 gca tot ogg got Ala Ser Arg Ala coo Pro 300 gga gtg gtg oag Gly Val Val Gin tta aag oga goa Leu Lys Arg Ala gat gcg ttg gat Asp Ala Leu Asp aaa gog ttg gao Lys Ala Leu Asp gtt Val 320 co cog got cog Pro Pro Ala Pro 1027 1075 1123 coa ttg ctt otg Pro Leu Leu Leu cot Pro 330 aco ttg aaa gtg Thr Leu Lys Val oca gat aaa ccc Pro Asp Lys Pro atg gtg Met Val 340 gao ttt tog Asp Phe Ser oat toa gtg His Ser Val 360 ott ttt gta coo Leu Phe Val Pro cgc ttg cgt otg Arg Leu Arg Leu cca ggc toa Pro Gly Ser 355 gao aac ggo Asp Asn Gly 11,71 1219 gta tca ggt gao Val Ser Gly Asp ata gtg ato act Ile Val Ile Thr ggt Gi y 370 got ggo Ala Giy 375 aaa toa aog oto Lys Ser Thr Leu ato Ile 380 gaa gto ttg tot Glu Val Leu Ser gtt ttg act oog Val Leu Thr Pro agt ggt tog gtt Ser Gly Ser Val aao oat goo oga Asn His Ala Arg act Thr 400 ggg gtt oto ggo Gly Val Leu Gly ca a Gin 405 1267 1315 1363 gaa toa ott gto Glu Ser Leil Val ggc Gi y 410 gag gtg coa toa Giu Val Pro Ser ata Ile 415 gca oga gat cao Ala Arg Asp His gca gtt Ala Val 420 aag tgg gga Lys Trp Gly tto tca att Phe Ser Ile 440 tta agt gtt gag Leu Ser Val Glu ago oga ttt gc Ser Arg Phe Ala ota cag gaa Leu Gin Glu 435 tcg tta got Ser Leu Ala 1411 1459 ggt caa ogo aga Gly Gin Arg Arg ota gat ttg gc Leu Asp Leu Ala atg Met 450 ggc aat Gly Asn 455 oct gaa ctg ttg Pro Giu Leu Leu ott Le u 460 oto gat gaa oct Leu Asp Giu Pro aao oat otg tot Asn His Leu Ser 1507 1555 atg oao ttg gtt too gca ott aca gag tgg otg gao aog aco gcg got Met His Leu Val Ser Ala Leu Thr Glu Trp Leu Asp Thr Thr Ala Ala 470 475 480 485 gca qtq atc atg gta acg cat gat cga cag cta ctc cgc gat acg gct 1603 Ala Val Ile Met Val Thr His Asp Arg Gin Leu Leu Arg Asp Thr Ala 490 495 500 cat tgg agg cac atc gag ttg aaa tct taagaattcg caagggcttt 1650 His Trp Arq His Ile Giu Leu Lys Ser 505 510 cac 1653 (210> 356 <211> 510 <212> PRT <213> Corynebacterium glutamicum (400> 356 Met Ala Lys Thr His Ile Arg Leu Gin Asp Leu Ser Leu Ser Tyr Thr 1 5 10 Ser Thr Pro Leu Ile Thr Lys Leu Asn Ile Thr Val Ser Ser Gly Gin 25 Cys Ala Val Ile Val Gly Glu Asn Gly Arg Gly Lys Thr Thr Leu Leu 40 Arg Ala Leu Ala Arg Giu Phe Pro Pro Ser Ala Gly Giu Ile Leu Thr 55 His Gly Thr Val Aia Ile Ala His Gin His Met Pro Ala Gly Asp Leu 70 75 Ser Val Gly Giu Ile Cys Asp Glu Ala Ile Arg Asp Ser Lys Asn Ala 90 Leu Glu Giu L ,eu Giu Arg Ala Gly Ala Leu Leu Glu Thr Asn Thr Ala i00 lo5 110 His Ala Leu Asp Gly Tyr Gin Gin Ala Leu Asp Ala Ala Giu Val Leu 115 120 125 Asp Ala Trp Asn Ala Giu His Arg Leu Giu Lys Ala Leu Arg Ser Phe 130 135 140 Gly Ala Ile Thr Asp Arg Ser Arg Ala Leu Ser Gin Len Ser Ile Gly 145 150 155 160 Gin Arg Tyr Arg Val Arg Len Ala Cys Leu Ile Gly Gly Asp Ala Asp 165 170 175 Ile Len Len Leu Asp Giu Pro Thr Asn His Leu Asp Arq Gly Ala Leu 180 185 190 Asn Tyr Leu Thr Gin Ala Ile Thr Ser His Lys Gly Val Val Leu Val 195 200 205 Val Ser His Asp Gin Ala Leu Ile Lys Asp Val Ala Asp Phe Ile Ile 210 215 220 Asp Ile Asp Ser Thr Pro Asp Gly Leu Pro Arg Ile Tyr His Glu Gly 225 230 235 240 Phe Asp See Tyr Arg Arg Gin Arg Ser Ala Leu Leu Glu Thr Trp Arg 245 250 255 Gin Asp Tyr Ala Ala Ala Gin Thr Val Gin Gin Gin Leu Gin Glu Asp 260 265 270 Leu Glu His Ala Arg Gin Arg Val Asn Ser Ser Trp Lys Pro Pro Lys 275 280 285 Gly Thr Gly Lys His Thr Arg Ala Ser Arg Ala Pro Gly Val Val Gin 290 295 300 Ala Leu Lys Arg Ala Gin Asp Ala Leu Asp Ser Lys Ala Leu Asp Val 305 310 315 320 Pro Pro Ala Pro Ala Pro Leu Leu Leu Pro Thr Leu Lys Val Arg Pro 325 330 335 Asp Lys Pro Met Val Asp Phe Ser Asp Leu Phe Val Pro His Arg Leu 340 345 350 Arg Leu Pro Gly Ser His Ser Val Val Ser Gly Asp Lys Ile Val Ile 355 360 365 Thr Gly Asp Asn Gly Ala Gly Lys Ser Thr Leu Ile Glu Val Leu Ser 370 375 380 Gly Val Leu Thr Pro Ala Ser Gly Ser Val Ala Asn His Ala Arg Thr *385 390 395 400 Gly Val Leu Gly Gin Glu Ser Leu Val Gly Glu Val Pro Ser Ile Ala 405 410 415 Arg Asp His Ala Val Lys Trp Gly Leu Leu Ser Val Glu Glu Ser Arg 420 425 430 Phe Ala Leu Gin Glu Phe Ser Ile Gly Gin Arg Arg Arg Leu Asp Leu 435 440 445 Ala Met Ser Leu Ala Gly Asn Pro Glu Leu Leu Leu Leu Asp Glu Pro 450 455 460 Ser Asn His Leu Ser Met His Leu Val Ser Ala Leu Thr Glu Trp Leu 465 470 475 480 Asp Thr Thr Ala Ala Ala Val Ile Met Val Thr His Asp Arg Gin Leu 485 490 495 Leu Arg Asp Thr Ala His Trp Arg His Ile Glu Leu Lys Ser 500 505 510 <210> 357 <211> 879 <212> DNA <213> Corynebacterium glutamicum <220> <221> COS <222> (101)..(856) <223> RXN02515 <400> 357 gtggctaagc acagttactt ggccaagctg ggcggcagaa tcagtttaaa attcgcttca accctqaaag attgtgacag aaaccggccc agctaatact atg agc act ctt gaa. 11! Met Ser Thr Leu Giu atc cgt aac ctg Ile Arg Asn Leu ca c His gca caq gtc Ctg Ala Gin Val Leu tcc gat gag tcc Ser Asp Glu Ser gct gag Ala Giu cct aag gaa Pro Lys Giu atc cac gcc Ile His Ala ctc aag ggc gtc Leu Lys Gly Val aac Asn ctc acc atc aac Leu Thr Ile Asn tct ggt gag Ser Gly Giu act ctt gct Thr Leu Ala 211 259 atc atg ggc cct Ile Met Gly Pro ggt tcc ggc aag Gly Ser Gly Lys tac acc Tyr Thr ctt ggt gga cac Leu Gly Gly His cgc tac gag gta Arg Tyr Glu Val gca ggc gag gtc Ala Gly Glu Val Ctc Leu ctc gac ggc gag Leu Asp Gly Giu atc ctg gag atg Ile Leu Giu Met gaa Giu gtt qat gag cgt Val Asp Giu Arg cgc gct ggt ctc Arg Ala Gly Leu ttc Ph e ctg gcc atg cag Leu Ala Met Gin cca act gaa atc Pro Thr Glu Ile cct ggc Pro Gly 100 gtt tcc gtt Val Ser Val gag gct cct Glu Ala Pro 120 aac ttc ctg cgt Asn Phe Leu Arg tCC Ser 110 gca gcg acc gca Ala Ala Thr Ala atc cgc ggc Ile Arg Gly 115 acc gct cag Thr Ala Gin aag ctt cgc gag Lys Leu Arg Glu tgg T rp 125 gtt aag gaa gtc Val Lys Giu Val cgC Arg 130 gaa gct Glu Ala 135 ctg gca att gac Leu Ala Ile Asp gag ttc tcc aac Giu Phe Ser Asn tca gtc aac gaa Ser Val Asn Glu ggt Gly 150 ttc tcc ggt ggc Phe Ser Gly Gly aag aag cgc cac Lys Lys Arg His gtt ctg cag ctt Val Leu Gin Leu gat Asp 165 547 595 643 ctg ctg aag cca Leu Leu Lys Pro ttc gcg atc atg Phe Ala Ile Met gat Asp 175 gag acc gac tcc Glu Thr Asp Ser ggc ctt Gly Leu 180 gac gtg gat Asp Vai Asp gca Al a 185 ctg cgc att gtt Leu Arg Ile Val gag ggc atc aac Glu Gly Ile Asn tcc tac aag Ser Tyr Lys 195 cag gag acc gaa ggt ggc atc ttg atg atc acc cac tac aag cgc atc Gin ctc Le u att Ile 230 ggC Giy Gi0 aac As n 215 gt g Vali tac Tyr Th r 200 tac Tyr acc Th r gac Asp Giy aag Lys ggt Giy t to Phe 250 Ile Leu Met Ile Thr His Tyr Lys Arg Ile 205 210 gac ttc att cac gtt tto gcg aat ggc cag Asp Phe Ile His Vai Phe Aia Asn Giy Gin 220 225 gct gag ott got gac aag otc gag got gac Aia Giu Leu Ala Asp Lys Leu Giu Aia Asp 240 245 aag taacatgtcc gatttcotca atg Lys <210> 358 <211> 252 <212> PRT (213> Corynebacterium qiutamicum <400> 358 Met Ser Thr Leu Giu Ile Arg Asn Leu 1 Asp Ile Lys Thr Val1 Thr Thr Vali Arg 145 Vali Thr Giu Asn Se r Al a Asp Giu Aila Arg 130 Se r Le u Asp Ser Ser Thr Giy Giu Ile Ile 115 Thr Val1 Gin Se r Aila Gly Leu Glu Arg Pro 100 Arg Al a As n Leu Gi y 180 Pro Ile Tyr Leu 70 Arg Vali Glu Giu Gly 150 Leu Asp Lys His Thr Leu Aila Ser Al a Al a 135 Phe Leu Val Glu Ile 25 Ala Ile 40 Leu Gly Asp Giy Giy Leu Val Aia 105 Pro Lys 120 Leu Ala Ser Giy Lys Pro Asp Ala 185 His 10 Leu Met Gly Giu Phe As n Leu Ile Gly Lys 170 Leu Ala Lys Gly His Asn 75 Leu Phe Arg Asp Giu 155 Phe Arg Val1 Vali As n Arg Le u Met Arg Trp 125 Giu Lys Ile Vali Leu As n Giy T yr Giu Gin Se r 110 Val1 Phe Ar g Met Ser 190 Pro Leu Ser Glu Met Tyr Ala Lys Ser His Asp 175 Giu Se r Thr Gly Val1 Glu Pro Al a Giu Asn Glu 160 Giu Gly Ile Asn Ser Tyr Lys Gin Glu Thr Glu Gly Giy Ile Leu Met Ile Thr 195 200 205 His Tyr Lys Arg Ile Leu Asn Tyr Val Lys Pro Asp 210 215 220 Phe Ala Asn Gly Gin Ile Val Thr Thr Gly Gly Ala 225 230 235 Lys Leu Giu Ala Asp Gly Tyr Asp Gin Phe Ile Lys 245 250 Phe Ile His Val Giu Leu Ala Asp 240 <210> <211> <212> <213> <220> <221> <222> <223> 359 1386 DNA Corynebacterium C DS (1363) RXN00525 giutamicum <400> 359 ccatcgtgtt tattacteac aaecctgagc ttgctgatga atctgatcgg gtgqteacca tggttgacgg gcqcatcatt qggtctgagg tgaaacactc atg age ctt gca qaa Met Ser Leu Ala Giu tca att cU: ttg Ser Ile Leu Leu geg Al a etc acc agc ctg Leu Thr Ser Leu aga Arg 15 age aac aaq atg Ser Asn Lys Met egt gca Arg Ala 163 ttg ttg aeg Leu Leu Thr att ttg ace Ile Leu Thr ctg tta gga gte ate Leu Leu Gly Val Ile ggt atc gca tca Gly Ile Ala Ser gtc ate gga Vai Ile Giy aat agt ttg Asn Ser Leu 211 259 att ggt aaa gee Ile Gly Lys Ala ct g Leu 45 cag gat eaa act Gin Asp Gin Thr t tg Leu gaa agc Giu Ser ttg ggc geg aat Leu Giy Ala Asn ctg teg gcg cag Leu Ser Ala Gin gag gaa cgc ccc Giu Giu Arg Pro gaa gat tcc ccc Giu Asp Ser Pro gaa Giu ccc gat atg tte Pro Asp Met Phe get Al a ttt tet ggg Phe Ser Giy get Ala aac tet agt ggc Asn Ser Ser Giy etg att ccg gaa Leu Ile Pro Giu aca gtt gat aeg Thr Val Asp Thr ctg cge Leu Arg 100 gat cgt tte Asp Arg Phe aeg caa ggc Thr Gin Gly 120 gea Al a 105 ggc age ate acg Gly Ser Ile Thr gga Gly 110 ate age gtt ggc Ile Ser Val Giy gga atg ggt Gly Met Gly 115 tee gat etc Ser Asp Leu act etc ate gge Thr Leu Ile Gly ace gea gat ett Thr Ala Asp Leu aaa Lys 130 etc gqe gte aac gag gat tat atg tgg atg aat gge gte gaa atg aac Leu Gly Val Asn Giu Asp Tyr Met Trp Met Asn Gly Vai Glu Met Asn 140 145 tac Tyr 150 ggc ogo goc ato Gly Arg Ala Ile caa gac gat gtt Gin Asp Asp Val gcc Al a 160 got cag ogc cOO Ala Gin Arg Pro gcg gtc atc gCC Ala Val Ile Ala cca Pro 170 gac acc ttt aat Asp Thr Phe Asn acg Thr 175 ott tto gao gca Leu Phe Asp Ala aao coo Asn Pro 180 aac ctc gct Asn Leu Ala aca ttt ttg Thr Phe Leu 200 ctg Leu 185 ggg tcc gaa gta Gly Ser Glu Val ttt gaa ctc aao Phe Giu Leu Asn ggt caa gag Gly Gin Giu 195 gca ggt gga Ala Giy Gly 691 739 cgg gtt atc gqt Arg Val Ile Gly tat aaa gaa qcc Tyr Lys Giu Ala ctt gtg Leu Vai 215 gga agc aat cca Gly Ser Asn Pro acc Thr 220 gtc cac acc tac Val His Thr Tyr acc Thr 225 oca tat acg gtg Pro Tyr Thr Val gc Al a 230 aat gao ato aoo Asn Asp Ile Thr acg gaa gat gga Thr Glu Asp Giy aac acg tta agt Asn Thr Leu Ser at o Ile 245 ogt gca got oag Arg Ala Ala Gin ggc Gly 250 gta gac oag gat Val Asp Gin Asp t ca Se r 255 ctt aag ggt tca Leu Lys Gly Ser ctg caa Leu Gin 260 acc tac ttc Thr Tyr Phe atg ttg gao Met Leu Asp 280 gcg otg tao goo Ala Leu Tyr Ala aat gao tog oao Asn Asp Ser His oao gtt goo His Val Ala 275 att oto ggo Ile Leu Gly tto ogt aaa oag Phe Arg Lys Gin gaa gag tto aao Giu Giu Phe Asn goa atg Ala Met 295 agt ttg ggt ato Ser Leu Gly Ile t oa Se r 300 goo ato ggo gga Ala Ile Gly Gly att too ttg ott Ile Ser Leu Leu 305 tot gto aoo gag Ser Val Thr Glu gto Val1 cga Arg 325 ggt Gly 310 ggo atc gga gtg Giy Ile Gly Val aao att atg ttg Asn Ile Met Leu 1027 1075 1123 aoc ogo gaa atc Thr Arg Giu Ile ggt Gly 330 gto oga aaa goo Val Arg Lys Ala ot c Leu 335 ggo got ogt oga Gly Ala Arg Arg ogt gao Arg Asp 340 att ogo otg Ile Arg Leu ggc ato oto Gly Ile Leu 360 tto gto gtt gaa Phe Val Val Glu atg ato att tgt Met Ile Ile Cys tto atc ggt Phe Ile Gly 355 ato atg too Ile Met Ser 1171 1219 ggo gtg ott ttg Gly Val Leu Leu ggo Gly 365 ggo att ttg gga Gly Ile Leu Gly ago got Ser Ala 375 att ggo tao att Ile Gly Tyr Ile ttg cca ooa otg Leu Pro Pro Leu agt Ser 385 gga ato gtg ato Gly Ile Val Ile 1267 9cc ttg gta ttt tcc atg gct atc ggc ctg ttt ttc ggc tac tac ccc Ala Leu Val Phe Ser Met Ala Ile Gly Leu Phe Phe Gly Tyr Tyr Pro 390 395 400 405 qcc aac aag gca gca aag ctc gat cca att gac gcc ttg cgt tat gag Ala Asn Lys Ala Ala Lys Leu Asp Pro Ile Asp Ala Leu Arg Tyr Glu 410 415 420 taaaagcctc gtttttaagg tag <210> 360 <211> 421 <212> PRT <213> Corynebacterium glutamicum 1315 1363 1386 <400> 360 Met 1 Asn Ala Thr Val Phe Va1 Va1 Leu Gly 145 Ala Phe Leu Ala Thr Ser Lys Ser Leu Glu Ser Asp Gly Lys 130 Val1 Gin Asp Asn Ala 210 Pro Leu Met: Val As n Glu Gly Thr Gly 115 Ser Glu Ar Ala Gly 195 Ala Tyr Ala Glu Ser Ile Leu Leu Arg Ile Ser Arg Ala Leu 100 Met Asp Met Pro Asn 180 Gin Gly Thr 5 Ala Gly Leu Pro Ala Arg Gly Leu Asn Val 165 Pro Glu Gly Val Leu Ile Glu Asp 70 Asn Asp Thr Leu Tyr 150 Ala Asn Thr Leu Ala Leu Leu Ser 55 Glu Ser Arg Gin Gly 135 Gly Va1 Leu Phe Va1 215 Asn Thr Thr 40 Leu Asp Ser Phe Gly 120 Va1 Arg Ile Ala Leu 200 Gly Asp Ala Leu Thr 10 Leu Gly Val Gly Lys Ala Ala Asn Asp Pro Giu Pro 75 Asn Leu Ile 90 Gly Ser Ile Leu Ile Gly Glu Asp Tyr 140 Ile Thr Gin 155 Pro Asp Thr 170 Gly Ser Glu Val Ile Gly Asn Pro Thr 220 Thr His Thr Ser Ile Leu Leu Asp Pro Thr Asp 125 Met Asp Phe Val Va1 205 Va1 Leu Ile Gin Ser Met Glu Gly 110 Thr Trp Asp Asn Ala 190 Tyr His Arg Gly Asp Ala Phe Glu Ile Ala Met Va1 Thr 175 Phe Lys Thr Ser Ile Gin Gin Ala Thr Ser Asp Asn Ala 160 Leu Glu Glu Tyr Glu Asp Gly Leu 225 230 235 240 Asn Thr Leu Ser Ile Arg Ala Ala Gin Gly Val Asp Gin Asp Ser Leu 245 250 255 Lys Gly Ser Leu Gin Thr Tyr Phe Asp Ala Leu Tyr Ala Asn Asn Asp 260 265 270 Ser His His Val Ala Met Leu Asp Phe Arg Lys Gin Ile Glu Giu Phe 275 280 285 Asn Thr Ile Leu Gly Ala Met Ser Leu Gly Ile Ser Ala Ile Gly Gly 290 295 300 Ile Ser Leu Leu Val Gly Gly Ile Gly Val Met Asn Ile Met Leu Val 305 310 315 320 Ser Val Thr Glu Arg Thr Arg Glu Ile Gly Val Arg Lys Ala Leu Gly 325 330 335 Ala Arg Arg Arg Asp Ile Arg Leu Gin Phe Val Val Glu Ala Met Ile 340 345 350 Ile Cys Phe Ile Gly Giy Ile Leu Gly Val Leu Leu Gly Giy Ile Leu 355 360 365 Gly Leu Ile Met Ser Ser Ala Ile Gly Tyr Ile Ser Leu Pro Pro Leu 370 375 380 Ser Gly Ile Val Ile Ala Leu Vai Phe Ser Met Ala Ile Gly Leu Phe 385 390 395 400 Phe Gly Tyr Tyr Pro Ala Asn Lys Ala Ala Lys Leu Asp Pro Ile Asp 405 410 415 Ala Leu Arg Tyr Giu 420 <210> 361 <211> 1815 <212> DNA <213> Corynebacterium giut-amicum <220> <221> CDS <222> (101)..(1792) <223> RXN02096 <400> 361 cgcttcqacg acctcaccca cagcgatatc cgcaggaatc tcatcgcggt ttttgatgag ccgttcttgt actcctcctc cataccgcga gaacatctcg atg ggt ttg gat gtc 115 Met Gly Leu Asp Val 1 agt gat gag cag atc gaa cac gca gcc agg ott gco cag got cat gat 163 Ser Asp Glu Gin Ile Glu His Ala Ala Arg Leu Ala Gin Ala His Asp 15 ttt atc gat cgo ctt oca aac aaa tao gag gaa gtc att ggc gaa cgc 211 Phe Ile Asp ggc ctg acg Gly Leu Thr Leu Pro Asn Lys Glu Glu Val IleGly Glu Arg ctc gca ogg Leu Ala Arg ctt tct ggt ggt Leu Ser Gly Gly caa. Gin cgc caa cgc atc Arg Gin Arg Ile gct ttc Ala Phe ctg gcg cat ccc Leu Ala His Pro gtg ttg gtg ctt Val Leu Val Leu gat Asp gat gcc acc tct Asp Ala Thr Ser gcc Al a att gat gcc tcc Ile Asp Ala Ser gag gac cgc att Giu Asp Arg Ile t tc Phe cag gcc ttg cgc Gin Ala Leu Arg gaa ctg cac gat Giu Leu His Asp gtc Val1 acc att ttg atc Thr Ile Leu Ile gcg cac cgc cac Ala His Arg His tcc act Ser Thr 100 ttq gag oto Leu Giu Leu gca otg gga Ala Leu Gly 120 gat ogg gtt ggt Asp Arg Val Gly ctg Le u 110 gtc gaa gat gga Vai Giu Asp Giy cgg gta aca Arg Val Thr 115 ttc tog cat Phe Ser His ocg ttg agt gag Pro Leu Ser Glu cgt gat cac got Arg Asp His Ala cg t Arg 130 ctg atg Leu Met 135 gct ott gat tto Ala Leu Asp Phe gat tot cac gat Asp Ser His Asp gaa tto aoo ctc Giu Phe Thr Leu gac Asp 150 aac ggt tca cta Asn Gly Ser Leu ccc Pro 155 ago caa gag caa Ser Gin Glu Gin ttg Leu 160 tgg ocg gag gtc Trp Pro Giu Val aca gaa aag cag Thr Glu Lys Gin aag att ott gog Lys Ile Leu Ala goc oct ggt cga Aia Pro Gly Arg ggc cgt Gly Arg 180 ggc atg too Gly Met Ser Otg oca goa Leu Pro Ala 200 atg Met 185 oca goa aco cct Pro Ala Thr Pro gag Giu 190 ctg oto goc cag Leu Leu Ala Gin att gag gog Ile Giu Ala 195 agg cta cgo Arq Leu Arg 691 '739 gca acg gaa, qaa Ala Thr Giu Giu oga gtt gat gc Arg Val Asp Ala ggg Gly 210 aco agt Thr Ser 215 aco too ggt ttc Thr Ser Gly Phe ttg ctc agt tta Leu Leu Ser Leu ttc Phe 225 aag cag gto ogt Lys Gin Val Arg oto gto gtc gog Leu Val Val Ala gto Val 235 ato gog ttg ttg Ile Ala Leu Leu gtg ggc gta gc Val Gly Val Ala 787 835 883 gat cta goa ttt Asp Leu Ala Phe oca Pro .250 aca ctg atg ogo Thr Leu Met Arg gca Al a 255 goc ato gao aac Ala Ile Asp Asn ggt gtg Gly Val 260 oaa goa oaa ago aco too aog ttg tgq tgg ato goo ato goa ggo ago Gin Ala Gin Ser Thr Ser Thr Leu Trp Trp Ile Ala Ile Ala Gly Ser 265 gta gta gtc Val Val Val 280 ctt ctg tcc tgg Leu Leu Ser Trp gcc gcc gcg ate Ala Ala Ala Ile aac As n 290 aeg att atc Thr Ile Ile acg gca Thr Ala 295 cgc ace ggt gaa Arg Thr Gly Glu egg Arg 300 ctg ctt tac ggc Leu Leu Tyr Gly cgt ctg cgc tca Arg Leu Arg Ser gtq cat cta ttg Val. His Leu Leu etg tce atg age Leu Ser Met Ser tat Tyr 320 ttc gaa cqe ac Phe Giu Arg Thr a tg Met 325 1027 1075 1123 tcc ggc cgc ate Ser Gly Arg Ile atg Met 330 acg cgc atg ace Thr Arg Met Thr gac atc qac aac Asp Ile Asp Asn ctc tcg Leu Ser 340 tcc ttc etc Ser Phe Leu ctc atc ggt Leu Ile Gly 360 tea ggt ctg gcg Ser Gly Leu Ala aca gtt gtc tct Thr Val Val Ser gtg ggc acg Val Gly Thr 355 caa cta qca. Gin Leu Ala 1171 1219 gtg gte aec atg Val Val Thr Met etc Leu 365 gcc atc acc gac Ala Ile Thr Asp etc gtt Leu Val 375 gCg ctg tcc gtg Ala Leu Ser Val ccg ate ate atc Pro Ile Ile Ile gtg Vai 385 ctc act etc att Leu Thr Leu Ile cga ege atc agc Arg Arg Ile Ser tee Ser 395 agg ctg tac acc Arg Leu Tyr Thr tea cgc gag caa Ser Arg Glu Gin 1267 1315 1363 age cag gtc aac Ser Gin Vai Asn qg Al a 410 gta ttc cac gag Vai Phe His Giu ate gee ggt tta Ile Ala Gly Leu ege ace Arg Thr 420 geg eag atg Ala Gin Met gaa gca gag Giu Ala Giu 440 ege atg gaa gac Arg Met Giu Asp eaa Gin 430 gte ttt gac aat Val Phe Asp Asn tat gcg ggc Tyr Ala Gly 435 aeg gee ate Thr Ala Ile 1411 1459 gaa tte ega ege Glu Phe Arg Arg cgt gtg aaa tee Arg Val Lys Ser gee ate Ala Ile 455 tac ttc ceo gge Tyr Phe Pro Gly et t Leu 460 gge geg ete tet Gly Ala Leu Ser gaa Giu 465 ate gee cag gea Ile Ala Gin Ala gte etc ggt tte Val Leu Gly Phe gea etg caa gta Ala Leu Gin Val cge gge gac ate Arg Giy Asp Ile 1507 1555 1603 ace ggc qta etc Thr Gly Val Leu gt g Val. 490 gca ttc gtg etg Ala Phe Val Leu tac T yr 495 atg gge etg atg Met Gly Leu Met tte ggc Phe Gly 500 ce ate eaa Pro Ile Gin eta age eaa ate Leu Ser Gin Ilie gao tee tae eaa Asp Ser Tyr Gin caa gee gee Gin Ala Ala 515 1651 gtc 99c ttC cgt cgc atc acc gaa ctg etc gca acg eag ccc age Val Gly Phe Arg Arg Ile Thr Glu Leu Leu Ala Thr Gin Pro Ser 520 525 530 cag ate tgg gca eea aca ggc acg eta gg agg etg eca cgc age Gin Ile Trp Ala Pro Thr Gly Thr Leu Giy Arg Leu Pro Arg Ser 535 540 545 tat tge ttg acg acg tea cet teg get att eag acg atc cga tcc Tyr Cys Leu Thr Thr Ser Pro Ser Ala Ile Gin Thr Ile Arg Ser 550 555 560 taqaeaacqt cacegtceag ate <210> 362 <211> 564 <212> PRT <213> Corynebacterium giutamicum 1699 1747 1792 1815 <400> 362 Met Giy Leu Asp Val Ser Asp Giu Gin 1 Ala Vali Ile Asp Gin His Asp Ala Pro 145 T rp Pro His Glu Al a Thr Arg Ser 100 Val1 Ser Thr Val1 Gly 180 Phe Gly Al a Ala 70 Giu Leu Al a Leu Asp 150 Thr Gly Asp Thr Leu Asp His Leu Giy 120 Al a Gly Lys Ser Ar g 25 Leu Aia Al a Asp Gly 105 Pro Leu Ser Gin Met 185 Ile 10 Leu Ser His Ser Val1 Asp Leu Asp Leu Tyr 170 Pro Giu Pro Gly Pro Thr 75 Thr Ar g Ser Phe Pro 155 Lys Ala Al a Lys Gin Val1 Asp Leu Gi y Met 125 Asp Gin Leu Pro Ala Tyr Arg Leu Arg Ile Leu 110 Arg Ser Giu Ala Glu 190 Arg Giu Gin Vali Ile Ile Val Asp His Gin Pro 175 Leu Leu Giu Arg Leu Phe Al a Giu His Asp Leu 160 Al a Leu Ala Gin Ile Giu Ala Leu Pro Ala Ala Thr Glu Glu Thr Arg Val Asp 195 200 205 Al a Phe 225 Val1 Ile Al a Ile Leu 305 Phe Ile ValI Asp Val1 385 Ser Al a Asp Ser Giu 465 Arg Gly Tyr Thr Gly 210 Lys Gly Asp Ile As n 290 Arg Giu Asp Ser Ala 370 Le u Arg Gly Asn Gin 450 Ile Gly Le u Gin Gin Arc; G 1 r Val1 As n Ala 275 Thr Le u Ar g Asn Va l 355 Gin Thr Giu Leu Tyr 435 Th r Ala Asp Met Gin 515 Pro Leu Vai Ala Gly 260 Gly Ile Arg Thr Leu 340 Gly Leu Leu Gin Arg 420 Ala Ala Gin Ile Phe 500 Ala Ser Ar gj Arg Al a 245 ValI Se r Ile Se r Met 325 Ser Th r Ala Ile Al a 405 Thr Gly Ile Ala Ser 485 Gi y Al a Val1 Thr Trp 230 Asp Gin Val1 Thr Phe 310 Ser Ser Leu Le u Phe 390 Ser Al a Giu Ala Leu 470 Thr Pro Val1 Gin Ser Thr 215 Leu Val1 Leu Ala Ala Gin Val Val 280 Ala Arg 295 Val His Gly Arg Phe Leu Ile Gly 360 Vai Ala 375 Arg Arg Gin Val Gin Met Ala Giu 440 Ile Tyr 455 Val Leu Gly Val Ile Gin Gly Phe 520 Ile Trp Ser Val1 Phe Ser 265 Leu Thr Leu Ile Gin 345 Val1 Le u Ile Asn His 425 Glu Phe Gly Leu Gin 505 Arg Ala Gly Al a Pro 250 Thr Leu Gly Leu Met 330 Ser Val1 Ser Ser Ala 410 Arg Phe Pro Phe Val1 490 Leu Arg Pro Phe Val1 235 Thr Ser Ser Glu Arg 315 Thr Gly Thr Val1 Sex 395 Val1 Met Arg Gly Gly 475 Al a Sex Ile Thr Lys 220 Ile Leu Thr T rp Arg 300 Leu Arg Leu Met Val 380 Arg Phe Glu Arg Leu 460 Ala Phe Gln Thr Gly Leu Ala Met Le u Ala 285 Leu Ser Met Al a Leu 365 Pro Leu His Asp Leu 445 Gly Leu Val1 Ile Giu 525 Thr Le u Leu Arg Trp 270 Al a Leu Met Thr Gin 350 Ala Ile T yr Giu Gin 430 Arg Al a Gin Leu Phe 510 Le u Le u Ser Leu Ala 255 Trp Ala T yr Ser Thr 335 Thr Ile Ile Thr Ser 415 Val Val Leu Val T yr 495 Asp Leu Gly Le u Leu 240 Al a Ile Al a Gi y Tyr 320 Asp ValI Thr Ile Al a 400 Ile Phe Lys Ser Thr 480 Met Sex Al a Arg 535 540 Leo Pro Arc; Ser Leu Tyr Cys Leu Thr Thr Ser Pro Ser Ala Ile Gin 545 550 555 560 Thr Ile Arg Ser <210>' <211> <212> <213> <220> <221> <222> <223> 363 1203 DNA Corynebacterium CDS (101). (1180) RXN 00)412 giutamicum <400> 363 cttttgacga acaccacgtc gcgtaegett cetcggggcg ttaaactatt tgtettccag cttttgtccc ccgacttttg tacgaatcga ggacaccgtc gtg tca cac acc gcg Val Ser His Thr Ala tee aca ccg acg Ser Thr Pro Thr gag gaa tac tce Glu Glu Tyr Ser gcg Al a cag eaa eec age Gin Gin Pro Ser ace cag Thr Gin gge act egc Gly Thr Arg aaa tet get Lys Ser Ala gtt Val gag ttc egc ggc Glu Phe Arg Gly ace aaa, gtc ttt Thr Lys Val Phe agc aac aat Ser Asn Asn ace gta gaa Thr Val Glu 211 259 aaa ace ace geg Lys Thr Thr Ala ct t Leo gat aat gte act Asp Asn Vai Thr eec ggt Pro Gly gag gta ate ggc Giu Val Ile Gly ate ggt tac tet Ile Giy Tyr Ser gge Gly gee gge aag tee Ala Gly Lys Ser aet Thr ett gte ege ete Leu VaIL Arg Leo ate Ile aat gge ett gac Asn Gly Leo Asp eec aeg age ggt Pro Thr Ser Gly ttg etg etc aac Leu Leo Leo Asn gge Gly aee gae ate gte Thr Asp Ile Val gga Gly 95 atg eee gag tct Met Pro Glu Ser aag ctg Lys Leo 100 egt aaa etg Arg Lys Leo tte eag teg Phe Gin Ser 120 ege Arg 105 agt aat ate gge Ser Asn Ile Gly att tte cag zag Ile Phe Gin Gin ttc aac ctg Phe Asn Leo 115 etg gaa gtt Leu Giu Val egt aet geg get Arg Thr Ala Ala gga Gly 125 aat gtg gag tac Asn Val Glu Tyr gce aag Ala Lys 135 atg gae aag gca Met Asp Lys Aia cgt aaa get ege Arg Lys Ala Arg gtg Val 145 caa gaa atg etc Gin Giu Met Leo ttc gte ggc ctg Phe Val Gly Leu ggc Gi y 155 gac aaa ggc aaa Asp Lys Giy Lys tac ccc gag cag Tyr Pro Glu Gin tcg ggc ggc cag Ser Gly Gly Gin aag Lys 170 cag cgc gtc ggc Gin Arg Vai Gly att Ile 175 gcc cgt gca ctg Ala Arg Ala Leu gcc ace Ala Thr 180 aat eca accl Asn Pro Thr gaa acc ace Giu Thr Thr 200 ttg ctt gcc gac Leu Leu Ala Asp gcc ace tec get Ala Thr Ser Ala ttg gac cca Leu Asp Pro 195 aac cgc gaa Asn Arg Glu cat gaa gtt ctg His Glu Val Leu ctg ctg cgc aag Leu Leu Arg Lys ctg ggc Leu Gly 215 ate acc atc gtt Ile Thr Ile Val gtg Val 220 ate ace cac gaa Ile Thr His Glu atg Met 225 gaa gtt gtg cgt Glu Vai Val Arg ate gca gac aag Ile Ala Asp Lys get gtg atg gaa Ala Val Met Glu gge aaa gtt gtg Gly Lys Val Val 787 835 883 tac ggc age gte Tyr Gly Ser Val tac Tyr 250 gag gtg tte tc Glu Val Phe Ser aat Asn 255 eca caa aca cag Pro Gin Thr Gin gtt get Val Ala 260 caa aag ttc Gin Lys Phe teg gaa gat: Ser Giu Asp 280 gee ace geg etg Ala Thr Ala Leu aac ace eca gac Asn Thr Pro Asp caa gtg gaa Gin Val Giu 275 att gat ctg Ile Asp Leu ctg ctt age cat Leu Leu Ser His gga egt ctg tte Giy Arg Leu Phe act gaa Thr Glu 295 aegi tee gge tte Thr Ser Gly Phe ttt Phe 300 gca gca ace get Ala Ala Thr Ala egt Arq 305 get gee gaa eaa Ala Ala Giu Gin get ttt gtc aac Ala Phe Val Asn ate Ile 315 gtt eac ggt gge Val His Gly Gly ace ace ttg caa Thr Thr Leu Gin ege Arg 325 1027 1075 1123 eaa tea ttt ggc Gin Ser Phe Gly aaa Lys 330 atg act gtt ega Met Thr Val Arg ace ggc aae ace Thr Gly Asn Thr get geg Ala Ala 340 att gaa gag Ile Glu Gluj ate ace ega Ile Thr Arg 360 <210> 364 <211> 360 <212> PRT tat eaa ace ttg Tyr Gin Thr Leu aag ace aeg ace Lys Thr Thr Thr ate aag gag Ile Lys Glu 355 1171 tgaacgagat gatectcgca get 1203 <213> Corynebacterium giutamicun <400> 364 Val Ser His Thr Ala Ser Thr Pro Thr Pro Glu Giu Tyr Ser Ala Gin 1 5 10 Gin Pro Ser Thr Gin Cly Thr Arg Val Glu Phe Arg Gly Ile Thr Lys 25 Val Phe Ser Asn Asn Lys Ser Ala Lys Thr Thr Ala Leu Asp Asn Val 40 Thr Leu Thr Val Giu Pro Gly Giu Val Ile Gly Ile Ile Gly Tyr Ser 55 Gly Ala Gly Lys Ser Thr Leu Val Arg Leu Ile Asn Gly Leu Asp Ser 70 75 Pro Thr Ser Gly Ser Leu Leu Leu Asn Gly Thr Asp Ile Val Gly Met 90 Pro Giu Ser Lys Leu Arg Lys Leu Arg Ser Asn Ile Gly Met Ile Phe 100 105 110 Gin Gin Phe Asn Leu Phe Gin Ser Arg Thr Ala Ala Gly Asn Val Giu 115 120 125 Tyr Pro Leu Giu Val Ala Lys Met Asp Lys Ala Ala Arg Lys Ala Arg 130 135 140 Val Gin Glu Met Leu Giu Phe Val Gly Leu Gly Asp Lys Gly Lys Asn 145 150 155 160 Tyr Pro Glu Gin Leu Ser Gly Giy Gin Lys Gin Arg Val Gly Ile Ala 165 170 175 Arq Ala Leu Ala Thr Asn Pro Thr Leu Leu Leu Ala Asp Giu Ala Thr 180 185 190 Ser Ala Leu Asp Pro Glu Thr Thr His Giu Val Leu Giu Leu Leu Arg 195 200 205 Lys Val Asn Arg Glu Leu Gly Ile Thr Ile Val Val Ile Thr His Giu 210 215 220 Met Giu Val Val Arg Ser Ile Ala Asp Lys Val Ala Val Met Giu Ser 225 230 235 240 Gly Lys Val Val Giu Tyr Gly Ser Val Tyr Glu Val Phe Ser Asn Pro 245 250 255 Gin Thr Gin Val Ala Gin Lys Phe Val Ala Thr Ala Leu Arg Asn Thr 260 265 270 Pro Asp Gin Val Glu Ser Giu Asp Leu Leu Ser His Giu Gly Arg Leu 275 280 285 Phe Thr Ile Asp Leu Thr Giu Thr Ser Giy Phe Phe Ala Ala Thr Ala 290 295 300 Arq Ala Ala Glu Gin Gly Ala Phe Vai Aso Ile Val His Gly Gly Val 310 315 Thr Thr Leti Gin Arg Gin Ser Phe Gly Lys 325 330 Met Thr Val Arg Leu Thr 335 Gly Asn Thr Ala Ala Ile Glu Glu Phe 340 345 Thr Thr Ile Lys Giu Ile Thr Arg 355 360 Tyr Gin Thr Leu Thr Lys Thr 350 <210> 365 (211> 798 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (775) <223> RXN00411 <400> 365 oatttggcaa aatgactgtt cgactcaccg gcaacaccgc tgcgattqaa gagttctatc aaaocttgac caagaccaog accatcaagg agatcacccg atg aac gag atg Met Asn Giu Met otc gca got gao Leu Ala Ala Asp aac cgg cta gga ccc acc ttc oaa aca Asn Arg Leu Gly Pro Thr Phe Gin Thr gcc atc Ala Ile att gao acc Ile Asp Thr ctg ggt ctt Leu Gly Leu otg Leu ttg atg gto atc Leu Met Val Ile atc Ile 30 acc atg gtg gtg got ggc tta Thr Met Val Vai Ala Gly Leu gtc gto ggc ctg Val Val Gly Leu ott tao acc aco Leu Tyr Thr Thr cg c Arg so got ggt gga Ala Gly Gly atc ttg Ile Leu aag aao aag gto Lys Asn Lys Val tao aco att ttq Tyr Thr Ile Leu gtg otg gtg aao Val Leu Val Asn gtt cga 000 ato Val Arg Pro Ile tto att att ttg Phe Ile Ile Leu goc gco ato aag Ala Ala Ile Lys ca Pro ota aog gto goo gto atg ggo aco tco atc ggc cga gat gco ggc atc Leu Thr Val Ala Val Met Gly Thr Ser Ile Gly Arg Asp Ala Gly Ile 403 ttc gtc atg Phe Val Met oaa aao ttg Gin Asn Leu 120 gtt Vai 105 gtc gca gcg att Val Ala Ala Ile tot gtg got oga Ser Val Ala Arg ato gtg gag Ile Val Giu 115 got ogc too Ala Arg Ser gto too att gat Vai Ser Ile Asp oct Pro 125 ggt gto ato gag Gly Val Ile Giu IL atg ggt gcg tcc ccg atg cgc atc atc Met Gly Ala Ser Pro Met Arg Ile Ile 135 140 gca ctt gga cca ttg gtt ctg ggt tac Ala Leu Gly Pro Leu Val Leu Gly Tyr 150 155 gtc gat atg tcc gca atg gtc ggc tac Val Asp Met Ser Ala Met Val Gly Tyr 170 gac ttc gcc att gtt tac ggc tac cgc Asp Phe Ala Ile Val Tyr Gly Tyr Arg 185 190 tac gtt gcc gtc ctg gtt atc gtc atc Tyr Val Ala Val Leu Val Ile Val Ile 200 205 ctg ggc aat tgg ctg tcc aag aag atc Leu Gly Asn Trp Leu Ser Lys Lys Ile 215 220 gcatagaaaa acc <210> 366 (211> 225 <212> PRT <213> Corynebacterium glutamicum <400> 366 Met Asn Giu Met Ile Leu Ala Ala Asp gcc Ala acc Thr atc Ile 175 gCC Ala atc Ile atg Met Trp 10 Leu Val Lys Ile Va1 Va1 Ser Pro Leu acc Thr ttc Phe 160 ggt Gly ttc Phe gtg Va1 cgc Arg Asn Met Gly Va1 Pro Met Ala Ile Met Va1 gtg Val 145 ctg Leu ggC Gly gac Asp cag Gin cgc Arg 225 Arg Va1 Leu Ile Phe Gly Ala Asp Arg 140 Leu atc att cca Ile Ile Pro ttc atc gcg Phe Ile Ala ggt ggt ctt Gly Gly Leu 180 aac gaa gtt Asn Giu Val 195 gca gcc cag Ala Ala Gin 210 taaacctctt gaa Glu atc Ile 165 ggt Gly atg Met ctt Leu 547 595 643 691 739 785 1 Phe Val Thr Asn Ala Arg Ala Glu Va1 Thr Ala Ala Leu Ile Ala Ile 115 Ala Ile Ala Gly Gly Va1 Lys Gly 100 Va1 Arg Pro Ile Leu Ile Phe 70 Leu Phe Gin Met Ala Thr Leu Lys Arg Val Met Leu 120 Ala Gly Gly Ile Leu Thr Ile Ser Phe 110 Gly Ile Tyr Pro Thr Tyr Ile Leu Ile Ser Va1 Ala Thr I 145 150 Leu Phe Ile Ala Ile Val 165 Gly Giy Giy Leu Gly Asp 180 Asp Asn Giu Val Met Tyr 195 Gin Ala Ala Gin Leu Leu 210 Arcj 225 <210> 367 <211> 852 <212> DNA <213> Corynebacterium gi <220> <221> CDS <222> (829) <223> RXN02614 <400> 367 tcattgtata cgccaccctc gg 155 160 Asp Met Ser Ala Met Vai Gly Tyr Ile Gly 170 175 Phe Ala Ile Val Tyr Gly Tyr Arg Ala Phe 185 190 Val Ala Val Leu Val Ile Val Ile Ile Val 200 205 Gly Asn Trp Leu Ser Lys Lys Ile Met Arg 215 220 utarnicun tctgctgt ctqaagcgct gatcagagct tgggaacgtc acaccttccg ctaccgaaac gcataagaaa gttgctcgcc atg act gcc aca ttg Met Thr Ala Thr Leu t ca Ser act Thr gt a Val1 09 C Arg tcC Ser aaa Lys tcc Ser ccc Pro gt c ValI ct 9 Leu gcg Ala cc g Pro ct C Le u ga a Glu gc Al a caa Gln gga Gi y cta Le u gtt Val1 aat Asn ca a Gln gtc Val atc I le tca Ser aaa Lys ttc Phe acc Thr cgc Arg cgt Arg gac Asp 30 ggt Giy gag Giu caa Gin ttt Phe gcc Ala g ga Gly ctc Leu t ca Ser cat His gag Glu ggc Gi y t cg Ser 1 cgc Arg atc Ile aaa Lys ggC Gly cgc Arg aac Asn Ct g Le u aaa Lys aac Asn t cc Ser tct Se r ctg Leu cgc Arg Ott Le u tca Ser tgc Cys acc Thr gt a Val1 ttq Le u act Thr gca Ala tac Tyr ggc Gly atc Ile ga a Glu ccg Pro gat Asp 100 gaa Glu 105 110 115 aaa Ott ccc gao too gao gcc gcc tgg ccc ctc acg ctc too ggc ggc 499 Lys Leu Pro Asp Ser Asp Ala Ala Trp Pro Leu Thr Leu Ser Gly Gly 120 125 130 caa gcc cacj cgc gtc tcc ctt gcg cga gcg ctc atc toc gag cca gag 547 Gin Ala Gin Arg Val Ser Leu Ala Arg Ala Leu Ile Ser Giu Pro Giu 135 140 145 ott ttg ctt ctc gao gaa coo tto ggc gcc oto gat got ctg aca aga 595 Leu Leu Leu Leu Asp Giu Pro Phe Gly Ala Leu Asp Ala Leu Thr Arg 150 155 160 165 ctg aca goc caa gac ctg otg cto aaa aco gtg aac aco oga aao ttg 643 Leu Thr Ala Gin Asp Leu Leu Leu Lys Thr Val Asn Thr Arg Asn Leu 170 175 180 gga gtt ctg ctg gto aco cat gat gtt too gag goc ato goc ctg goc 691 Gly Val Leu Leu Val Thr His Asp Val Ser Giu Ala Ile Ala Leu Ala 185 190 195 gao oac gtc o tt ctt ott gao gao ggc goc ato aca cac agt ttg act 739 Asp His Val Leu Leu Leu Asp Asp Gly Ala Ile Thr His Ser Leu Thr 200 205 210 gta gat ato ccc ggc gat ogo ogo aco cac ccc too ttt goc too tao 787 Val Asp Ile Pro Giy Asp Arg Arg Thr His Pro Ser Phe Ala Ser Tyr 215 220 225 acc got caa oto ott. gag tgq oto gaa ato aoc aca oct goc 829 Thr Ala Gin Leu Leu Giu Trp Leu Giu Ile Thr Thr Pro Ala 230 235 24I0 tagaaagaaa tcatgaaatt taa 852 <210> 368 <211> 243 <212> PRT <213> Corynebaoterium giutarnicum (400> 368 Met Thr Ala Thr Leu Ser Leu Lys Pro Ala Ala Thr Val Arg Gly Leu 1 5 10 Arg Lys Ser Tyr Gly Thr Lys Giu Val Leu Gin Gly Ile Asp Leu Thr 25 Ile Asn Cys Gly Giu Val Thr Ala Leu Ile Gly Arg Ser Gly Ser Gly 40 Lys Ser Thr Ile Leu Arg Val Leu Ala Gly Leu Ser Lys Glu His Ser 55 Gly Ser Val Giu Ile Ser Gly Asn Pro Ala Val Ala Phe Gin Giu Pro 70 75 Arg Leu Leu Pro Trp Lys Thr Val Leu Asp Asn Val Thr Phe Gly Leu 90 Arg Leu Leu 130 Ser Al a Thr Ile His 210 Phe Pro Thr Al a 115 Ser Gl1u Le u Arg Al a 195 Ser Al a Al a Asp 100 Giu Gly Pro Thr Asn 180 Le u Le u Ser Trp Leu Ala 135 Leu Thr Val1 His Asp 215 Ala Ser Pro 120 Gin Leu Al a Le u Val1 200 Ile Gin Glu 105 Asp Arg Leu Gin Leu 185 Leu Pro Leu Ala Ser Val1 Asp Asp 170 Val1 Leu Gly Leu Glu Al a Leu 140 Pro Leu His Asp Arg 220 Trp Arg Ala 125 Al a Phe Leu Asp Asp 205 Arg Leu Ala Le u Leu Le u 160 Val1 Giu I le Pro Th r 240 <210> 369 <211> 1080 <212> DNA <213> Corynebacterium giutamicum <2 <221> CDS <222> (101)..(1057) <223> RXN02613 <400> 369 agatatcec ggcgatcgcc gcacccaccc ctcctttgcc tgagtggcte gaaatcaeca cacctqccta gaaagaaatc gc Al a tet Ser gt a Val1 caa gt t Val1 ga t Asp ctt Le u tca gce Ala gee Ala ate Ile gag eta Leu gee Ala 30 caa Gin ga t ggc Gly ga t Asp ate Ile gte ett Leu gga Gly gee Ala Get tectacaceg etcaactect atg aaa ttt aag aaa Met Lys Phe Lys Lys 1 gea tee tge tea tea Ala Ser Cys Ser Ser tee ate gat etg age Ser Ile Asp Leu Ser gga aca gaa eaa gtg Gly Thr Glu Gin Val tat aaa ate gaa tgg 115 163 211 259 307 Leu Gin Ala Ser Gly Giu Leu Asp Asp Val Pro Tyr Lys Ile Giu Trp tca ttt: acc tct Ser Phe Thr Ser 60 cca ccc caa ate Pro Pro Gin Ile gca tta aac gca Ala Leu Asn Ala gg a Gi y ggt Giv caa att gat; ttc Gin Ile Asp Phe ate aec gga aac Ile Thr Gly Asn eca ccg atc ate Pro Pro Ile Ile gge ggc Gly Giy 100 coo acc aac Pro Thr Asri gat gtc ate Asp Val Ile .120 aaa gtg gte tee Lys Val Val Ser gee Aia 110 tao aac aac gat get tta ggt Tyr Asn Asn Asp Ala Leu Gly 115 ttg gte gee ceg Leu Vai Ala Pro tct tea ata ado Ser Ser Ile Thr t eq Ser 130 gtg got gac Vai Ala Asp ett get Leu Aia 135 gga aag aaa gtg Gly Lys Lys Val get Al a 140 gte gee ego gga Val Ala Arg Giy ago gee cac gga Ser Ala His Gly cte ate eaa caa Leu Ile Gin Gln gaa aaa gca gge Giu Lys Ala Gly age gtt qae gao Ser Val Asp Asp gaa ate aac etc Giu Ile Asn Leu eaa eec toe gae Gin Pro Ser Asp aaa gee got tto Lys Ala Ala Phe eaa aae Gin Asn 180 gge eag gta Gly Gin Val gaa ctg gaa Giu Leu Giu 200 geg tgg goa gtg Ala Trp Ala Val tgg T rp 190 gat eec tao ago Asp Pro Tyr Ser tea eag geg Ser Gin Ala 195 otg gte agt Leu Val Ser gga got caa gtt Gly Ala Gin Val gte agg gga geg Val Arg Gly Ala gga Gly 210 ggg cat Gly His 215 gga ttt ggt gte Gly Phe Gly Val gca Ala 220 agt gat gaa gog Ser Asp Giu Ala gat gac coo gca Asp Asp Pro Ala aag Lys 230 gaa gee geo ttg Giu Ala Aia Leu gat tte eto gat Asp Phe Leu Asp gtg gee gac tot Val Ala Asp Ser tat T yr 245 gaa tgq got gaa Glu Trp Ala Giu aao ace gat gaa Asn Thr Asp Giu geg aeg att ttc Ala Thr Ile Phe ago caa Ser Gin 260 gaa tee ggc Giu Ser Gly ego oat cag Arg His Gin 280 gat cog gag gee Asp Pro Giu Ala tet Ser 270 caa ctg aae ace Gin Leu Asn Thr ego ago ctg Arg Ser Leu 275 eag aae gcg Gin Asn Ala gtg ceg ete gao Val Pro Leu Asp toe gte aae ace Ser Val Asn Thr ott ate gac got tte gte too geg ggt ote gtt gag gae ttt aat tte Leu Ile Asp Ala Phe Val Ser Ala Gly Leu Val Giu Asp Phe Asn Phe 1027 295 300 305 gag gac acc: gta gac acc cga ttt gaq gqc taagtatgtc tgtatqgc 1073 Giu Asp Thr Val. Asp Thr Arq Phe Giu Gly 310 315 aaa 1080 <210> 370 <211> 319 <212> PRT <213> Coryrnebacterium giutarnicum <400> 370 Met Lys Phe Lys Lys Ile Ala Leu Vai Leu Ala Phe Gly Leu Gly Leu 1 5 10 Ala Ser Cys Ser Ser Ala Ser Giy Asp Pro Ala Thr Asn Ala Asp Gly 25 Ser Ile Asp Leu Ser Lys Val Thr Leu Asn Ile Giy Asp Gin Ile Ala 40 Gly Thr Glu Gin Val Leu Gin Ala Ser Gly Glu Leu Asp Asp Val Pro 55 Tyr Lys Ile Giuv Trp, Ser Ser Phe Thr Ser Gly Pro Pro Gin Ile Glu 70 75 Ala Leu Asn Ala Giy Gin Ile Asp Phe Ala Ile Thr Gly Asn Thr Pro 90 Pro Ile Ilie Gly Gly Pro Thr Asn Thr Lys Val Val Ser Ala Tyr Asn 100 105 110 Asn Asp Ala Leu Gly Asp Val Ile Leu Val Aia Pro Asp Ser Ser Ile 115) 120 125 Thr Ser Val Ala Asp Leu Ala Gly Lys Lys Vai Ala Val Ala Arg Gly 130 135 140 Ser Ser Ala His Gly His Leu Ile Gin Gin Leu Giu Lys Ala Gly Val 145 150 155 160 Ser Val Asp Asp Val Giu Ile Asn Leu Leu Gin Pro Ser Asp Ala Lys 165 170 175 Ala Aia Phe Gin Asn Gly Gin Vai Asp Ala Trp Ala Val Trp Asp Pro 180 185 190 Tyr Ser Ser Gin Ala Giu Leu Giu Giy Ala Gin Val Leu Val Arg Gly 195 200 205 Ala Gly Leu Val Ser Gly His Gly Phe Giy Val Ala Ser Asp Giu Aia 210 215 220 Leu Asp Asp Pro Aia Lys Giu Ala Ala Leu Ala Asp Phe Leu Asp Arg 225 230 235 240 Val Ala Asp Ser Tyr Giu Trp Ala Glu Asp Asn Thr Asp Giu Trp Ala 245 250 Thr Ilie Phe Ser Gin Glu Ser Gly Phe Asp Pro 260 265 Asn Thr Arg Ser Leu Arg His Gin Val Pro Leu 275 280 Thr Tyr Gin Asn Ala Leu Ile Asp Ala Phe Val 290 295 Glu Asp Phe Asn Phe Glu Asp Thr Val Asp Thr 305 310 315 <210> 371 <211> 1698 <212> DNA <213> Corynebacterium giutamioum <220> <221> CDS <222> (1675) <223> RXN00368 <400> 371 ttcttccaaa acgcaatgaa ctagttttcc tatgcagtta 255 Glu Ala Ser Gin Leu 270 Asp Glu Ser Val Asn 285 Ser Ala Gly Leu Val 300 Arg Phe Giu Gly tctccttcaa atacgtcgac gcagogcttt cacatctctg cgttgacgtc tttgtotttc atg cgt ctg Met Arg Leu t gy Trp ggo Gly ttq Leu gtg Val1 act Thr ctg Leu ggg Gly att ctg Leu ttg Leu ggo Gly ggo Gly gat Asp ttg Le u aag Lys tac att Ilie gog Al a aaa Lys gog Al a gt t Val atc Ile ttg Leu aat As n aat Asn ggc Gly 60 acc Thr at t Ile aac As n gt g atc Ile ttt Ph e gco Al a atc Ile ttg Leu got Ala ttt Phe 110 ttt CCg Pro got Ala aca Thr got Al a tta Le u 80 gog Ala ggc Gi y ttg 1 ttg Leu ctg Le u aca Thr ctc Le u ttt Phe t gg Trp a cg Thr at gC~g Al a tgg Trp gt g Val1 aog Thr ttg Le u ttg Le u gaa Gl u gt g Ctg Le u gat Asp ctt Leu ctg Le u tta Le u cag Gin gt g Val1 115 cac ggt gtg Gly Val gtg gtg Val Val too gga Ser Gly tot gog Ser Ala gao oga Asp Arg too cog Ser Pro Ctg tto Leu Phe 100 tgg gat Trp Asp too tat aao oag Asn Gin 105 ggC gCt Ile Tyr Gly 120 Ala Asp Gly Val Ph Le Le li Phe Leu Leu Ile His Ser Tyr ccc act Pro Thr 135 gtg tac atc att Val Tyr Ile Ile tcg gca gct ctg Ser Ala Ala Leu a gg Arg 145 caa ctt cct agt Gin Leu Pro Ser gat Asp 150 ttg gag caa gct Leu Glu Gin Ala gca Al a 155 cgg atc gcg ggg Arq Ile Ala Gly gat act ttt acg Asp Thr Phe Thr ttg cgc acc atc Leu Arg Thr Ile ctc cca ctg ctc Leu Pro Leu Leu cct gca ttg ttg Pro Ala Leu Leu tcg gcg Ser Ala 180 ttt act ctt Phe Thr Leu ctg ttg gga Leu Leu Gly 200 aca gtg gcg aac Thr Val Ala Asn ctc be u 190 gcc gac ttt ggc Ala Asp Phe Gly att cca gct Ile Pro Ala 195 atg att tat Met Ile Tyr 691 739 tcg cca gcg cgt Ser Pro Ala Arg gaa acc tta gcc Giu Thr Leu Ala acc Thr 210 cgc ttc Arg Phe 215 atg gaa tcc ggc Met Giu Ser Gly acc Thr 220 gtg agc aat cca Val Ser Asn Pro cag gtg gta tcc Gln Val Val Ser att ggc atc qtg Ile Gly Ile Val ttg ttc ctq gga Leu Phe Leu Gly gca gca gta acc Ala Ala Val Thr gat tat ctg gtg Asp Tyr Leu Vai ttg tac gcq qca Leu Tyr Ala Ala aag ttg caa gac Lys Leu Gin Asp gca gga Ala Gly 260 aca ccg cat Thr Pro His atc acg tgg Ile Thr Trp 280 ttt act ctc aac Phe Thr Leu Asn tca cga atc cca Ser Arg Ile Pro gtc agc gtg Val Ser Val 275 ctg ctg ggt Leu Leu Giy atc atc gcg ttq Ile Ile Ala Leu atc acc gcc qcc Ile Thr Ala Ala ctg gca Leu Ala 295 tac aga gca tta Tyr Arg Ala Leu cct qcc cca ggt Pro Ala Pro Gly gtg Val1 305 ccg ttc aac cta Pro Phe Asn Leu gac Asp 310 aac atc acg ctc Asn Ile Thr Leu aac Asn 315 aac ttt gaa gca Asn Phe Giu Ala gca Ala 320 ctg agc aat cca Leu Ser Asn Pro 1027 1075 1123 1171 gta atc gaa gga Vai Ile Giu Gly agc aac tcc ctc Ser Asn Ser Leu tta tcc ctg ggt Leu Ser Leu Gly gca 9CC Ala Ala 340 cta atc tgt Leu Ile Cys gtg ctg gqa tgg Vai Leu Giy Trp ctg Leu 350 atc gga gtg ctc Ile Gly Val Leu atc acc cqa Ile Thr Arg 355 acc cag cat ttc gcc aac gta ccg ttg aca ctc act gtg ctg ctt ccc Thr Gin His Phe Ala Asn Vai Pro Leu Thr Leu Thr Val Leu Leu Pro 1219 acc gca ctg ceg ggc atg atc atc ggc gtc Thr Ala Leu Pro Gly Met Ile Ile Giy Val 375 380 aga tac acc gga att tac aac aca cct tgg Arg Tyr Thr Giy Ile Tyr Asn Thr Pro Trp 390 395 gtg tgt get ttt acc gcg ctg gtt qtc caa Vai Cys Ala Phe Thr Ala Leu Vai Vai Gin 410 415 agt caa gca ccc gaa gca atc gaa gaa gcc Ser Gin Ala Pro Giu Aia Ile Giu Giu Aia 425 430 ggc aga tta cga tce ate atg gac acc acc Giy Arg Leu Arg Ser Ilie Met Asp Thr Thr 440 445 gca get ttc gcc ggc gca gtg ctg gtt gcg Ala Ala Phe Ala Gly Ala Val Leu Val Ala 455 460 tta acc gtg tcc att ttg ctc ate geg ccg Leu Thr Vai Ser Ile Leu Leu Ile Ala Pro 470 475 gtg cag gtg ttc aat ttg cag cag gcg gga Val Gin Val Phe Asn Leu Gin Gin Ala Gly 490 495 gcg ttg teg ttg atg ttt gcg att ate ggt Ala Leu Ser Leu Met Phe Ala Ile Ile Gly 505 510 acg gtg cgc agc cag aag gag ttt taqgtgtc Thr Val Arg Ser Gin Lys Glu Phe 520 525 <210> 372 <211> 525 <212> PRT <213> Corynebacterium glutamicum <400> 372 Met Arg Leu Giy Val Trp Leu Ile Val Ala 1 5 10 Leu Ala Leu Vai Val Gly Leu Ala Leu Giy 25 Leu Trp Asp Ser Gly Leu Giy Lys Ala Leu 40 Thr Val Leu Ser Ala Val Gly Ala Thr Ile 55 ggC Gi y gtg Val1 400 get Al a gca Ala gga Gly gta Val1 gge Gly 480 aat As n atc t gg Trp 385 at t Ile gta Val1 cga Arg gcg Ala act Thr 465 acc Thr tac T yr gtg Ctc Le u ttg Leu cgc Arg atc Ile atg Met 450 gcg Al a ace Thr aat As n gcg Ala att Ile ggt Gly gga Gi y a gc Ser 435 g ca Ala qt t Val1 ace Thr cag Gin etc Le u t tg Leu gca Al a cca Pro 420 ggc Gly att Ile cga Arg ctg Leu gca Ala 500 gcg Al a ggc Gi y tat Tyr 405 ct c Leu gca Al a ccc Pro gag Gi u ggt Gl y 485 tcg Se r ttg Le u 1267 1315 1363 1411 1459 1507 1555 1603 1651 Ile Val :at cgatcaaatt gcg Gly Leu Phe Ile Thr Pro Gly Asn Gin Phe Pro Ala Trp Asn Ser Ala Tyr Thr Ile Gly Thr Ile Met Ala 1698 Leu Thr Leu Asp Arg Thr Asp Val Phe Gly Arq Thr Ala Leu Arg Leu 70 75 BO Phe Leu Leu Ser Pro Leu Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala 90 Trp Leu Gin Leu Phe Gly Lys Asn Gin Gly Ile Asn Arg Phe Phe Gly 100 105 110 Thr Giu Val Trp Asp Ile Tyr Gly Ala Asp Gly Vai Thr Phe Leu Leu 115 120 125 Ile Val His Ser Tyr Pro Thr Val Tyr Ile Ile Val Ser Ala Ala Leu 130 135 140 Arg Gin Leu Pro Ser Asp Leu Giu Gin Aia Ala Arg Ile Ala Giy Ala 145 150 155 160 Asp Thr Phe Thr Val Leu Arq Thr Ile Thr Leu Pro Leu Leu Lys Pro 165 170 175 Ala Leu Leu Ser Ala Phe Thr Leu Thr Thr Val Ala Asn Leu Ala Asp 180 185 190 Phe Gly Ile Pro Ala Leu Leu Giy Ser Pro Ala Arg Phe Glu Thr Leu 195 200 205 Ala Thr Met Ile Tyr Arq Phe Met Giu Ser Giy Thr Val Ser Asn Pro 210 215 220 Leu Gin Val Val Ser Thr Ile Gly Ile Val Leu Leu Phe Leu Gly Ile 225 230 235 240 Ala Ala Vai Thr Ala Asp Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys 245 250 255 Leu Gin Asp Ala Gly Thr Pro His Arg Phe Thr Leu Asn Lys Ser Arg 260 265 270 Ile Pro Val Ser Val Ile Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala 275 280 285 Ala Pro Leu Leu Gly Leu Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly 290 295 300 Val Pro Phe Asn Leu Asp Asn Ile Thr Leu Asn Asn Phe Glu Ala Ala 305 310 315 320 Leu Ser Asn Pro Arg Val Ile Giu Gly Phe Ser Asn Ser Leii Met Leu 325 330 335 Ser Leu Gly Ala Ala Leu Ile Cys Giy Val Leu Gly Trp Leu Ile Gly 340 345 350 Val Leu Ile Thr Arq Thr Gin His Phe Aia Asn Val Pro Leu Thr Leu 355 360 365 Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met Ile Ile Gly Val Gly 370 375 380 Trp Leu Ile Leu Gly Arg Tyr Thr Gly Ile Tyr Asn Thr Pro Trp Val 385 390 395 400 Ile Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu Val Val Gin Ala 405 410 415 Val Arq Gly Pro Leu Ser Gin Ala Pro Giu Ala Ile Giu Giu Ala Ala 420 425 430 Arg Ile Ser Gly Ala Gly Arg Leu Arg Ser Ile Met Asp Thr Thr Gly 435 440 445 Ala Met Ala Ile Pro Ala Ala Phe Ala Gly Ala Val Leu Val Ala Val 450 455 460 Thr Ala Val Arg Giu Leu Thr Val Ser Ile Leu Leu Ile Ala Pro Gly 465 470 475 480 Thr Thr Thr Leu Gly Val Gin Val E'he Asn Leu Gin Gin Ala Gly Asn 485 490 495 Tyr Asn Gin Ala Ser Ala Leu Ser Leu Met Phe Ala Ile Ile Gly Ile 500 505 510 Val Ala Leu Ala Leu Thr Vai Arg Ser Gin Lys Giu Phe 515 520 525 <210> 373 <211> 602 <212> DNA <213> Corynebacterium qiutamicum <220> <221> ODS <222> <223> FRXA00368 <400> 373 tcc ctc atg tta tcc ctg ggt gca gcc cia aic tgt qqg gig ctg gga 48 Ser Leu Met Leu Ser Leu Gly Ala Ala Leu Ile Cys Gly Val Leu Gly 1 5 10 tqq ctg atc gqa gtg ctc atc acc cga acc cag cat ttc gcc aac gta 96 Trp Leu Ile Giy Val Leu Ile Thr Arg.Thr Gin Hius Phe Ala Asn Val 25 ccg ttg aca ctc act gtg ctg ctt ccc acc gca ctg ccg ggc aig atc 144 Pro Leu Thr Leu Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met Ile 40 atc ggc gtc ggc tgg ctc att tig ggc aqa tac acc gga ait tac aac 192 Ile Giy Val Gly Trp Leu Ile Leu Gly Arg Tyr Thr Gly Ile Tyr Asn 55 aca cct tgq gtg ait ttq qgt qca tat gtg tgt gct ttt acc gcg ctg 240 Thr Pro Trp Val Ile Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu 70 75 gtt gtc caa qct gta cgc gga cca ctc agt caa gca ccc qaa gca atc 288 Val Val Gin Ala Val Arg Gly Pro Leu Ser Gin Ala Pro Giu Ala Ile 90 gaa gaa gcc gca cga atc agc qgc gca ggc aga tta cga tcc atc atgj 336 Giu Giu Ala Ala Arg Ile Ser Gly Ala Giy Arg Leu Arg Ser Ile Met 100 105 110 gac acc acc gga gcg atg gca att ccc gca gct ttc gcc ggc gca gtg 384 Asp Thr Thr Gly Ala Met Ala Ile Pro Ala Ala Phe Ala Gly Ala Val 115 120 125 ctg gtt gcg gta act gcg gtt cga qag tta acc gtg tcc att ttg ctc 432 Leu Val Ala Val Thr Ala Val Arg Glu Leu Thr Val Ser Ile Leu Leu 130 135 140 atc gcg ccg ggc acc acc acc ctg qgt gtg cag gtq ttc aat ttg cag 480 Ile Ala Pro Gly Thr Thr Thr Leu Gly Val Gin Val Phe Asn Leu Gin 145 150 155 160 cag gcg gga aat tac aat cag gca tcg gcg ttg tcg ttg atg ttt gcg 528 Gin Ala Gly Asn Tyr Asn Gin Ala Ser Ala Leu Ser Leu Met Phe Ala 165 170 175 att atc ggt atc gtg gcg ctc gcg ttg acg gtg cgc agc cag aag gag 576 Ile Ile Gly le Val Ala Leu Ala Leu Thr Vai Arg Ser Gin Lys Giu 180 185 190 ttt tagqtgtcat cgatcaaatt gcg 602 Phe <210> 374 <211> 193 <212> PRT <213> Corynebacterium giutamicum <400> 374 Ser Leu Met Leu Ser Leu Gly Ala Ala Leu Ile Cys Gly Vai Leu Gly 1 5 10 Trp Leu Ile Gly Val Leu Ile Thr Arg Thr Gin His Phe Ala Asn Val 25 Pro Leu Thr Leu Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met Ile 40 Ile Gly Val Gly Trp Leu Ile Leu Gly Arg Tyr Thr Gly Ile Tyr Asn 55 Thr Pro Trp Val Ile Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu 70 75 Val Val Gin Ala Val Arg Gly Pro Leu Ser Gin Ala Pro Giu Ala Ile 90 Giu Giu Ala Ala Arg Ile Ser Gly Ala Gly Arg Leu Arg Ser Ile Met 100 105 110 Asp Thr Thr Gly Ala Met Ala Ile Pro Ala Ala Phe Ala Gly Ala Val 115 120 125 Leu Val Ala Val Thr Ala Val Arg Giu Leu Thr Val Ser Ile Leu Leu 135 140 Ile Ala Pro Gly Thr Thr 145 150 Thr Leu Gly Val Gin 155 Val Phe Asn Leu Gin Ala Gly Ile Ile Gly Asn Tyr 165 Ile Val 180 Asn Gin Ala Ser Leu Ser Leu Met Phe Ala 175 Ala Leu Ala Thr Val Arg Ser Gin Lys Giu 190 <210> <211> <212> <213> <220> <221> <222> <223> 375 798 DNA Corynebacterium giutamicum CDS FRXA00370 <400> 375 ggc aaa gco cta tg Gly Lys Ala Leu Trp 1 5 aat tco goc tat Asn Ser Ala Tyr aca gtg ott tot Thr Val Leu Ser gcg gtg Ala Val ggo gcg acc Gly Ala Thr gat gtt ttc Asp Val Phe ato ggc acg ato Tie Gly Thr Ilie gct oto acg ctg Ala Leu Thr Leu gac cga act Asp Arg Thr tco ccg ctg Ser Pro Leu ggg cgc aco qcq Gly Arg Thr Ala cgq tta ttt ttq Arg Leu Phe Leu ttg atc Leu Ile cot cog ttt att. Pro Pro Phe Ilie ggg Gi y got att gcg tgg Ala Ile Ala Trp cag ctg ttc ggg Gin Leu Phe Gly aac cag ggc atc Asn Gin Gly Ile cgg ttt ttc ggc Arg Phe Phe Gly acg Thr gaa gtg tgq gat Glu Val Trp Asp 192 240 288 tac ggc got gat Tyr Gly Ala Asp qgt Giy gtg aca ttt ttg Val Thr Phe Leu att gtg cac too Ile Val His Ser tat ccc Tyr Pro act gtg tao Thr Val Tyr ttg gag caa Leu Giu Gin 115 att gtt tcg gca Ile Val Ser Ala otg agg caa ott Leu Arg Gin Leu oct agt gat Pro Ser Asp 110 acq gtg ttg Thr Val Leu got gca cgg ato Ala Ala Arg Ile ggg gog gat act Giy Ala Asp Thr ogo acc Arq Thr 130 ato aca oto oca Ile Thr Leu Pro ctg Leu 135 oto aaa cot gca Leu Lys Pro Ala ttg tog gog ttt Leu Ser Ala Phe act ctt acc aca gtg gcg aac ctc gcc gac ttt ggc att cca gct ctg 480 Thr Leu Thr Thr Val Ala Asn Leu Ala Asp Phe Gly Ile Pro Ala Leu 145 150 .155 160 ttq gqa tcq cca gq cqt ttt qaa acc tta gcc acc atq att tat cqc 528 Leu Gly Ser Pro Ala Arg Phe Giu Thr Leu Ala Thr Met Ile Tyr Arg 165 170 175 ttc atg gaa tcc gqc acc gtg ago aat cca ttg cag gtg gta tcc acc 576 Phe Met Giu Ser Gly Thr Val Ser Asn Pro Leu Gin Val Val Ser Thr 180 185 190 att ggc atc gtg ttg ttg ttc ctg gga atc gca gca gta acc gcg gat 624 Ile Gly Ile Val Leu Leu Phe Leu Gly Ile Ala Ala Val Thr Ala Asp 195 200 205 tat ctg gtg tct ttg tac qcq gca tca aag ttg caa gac gca gga aca 672 Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys Leu Gin Asp Ala Gly Thr 210 215 220 cog cat cgc ttt act ctc aac aaa tca cga atc cca gtc ago gtg atc '720 Pro His Arg Phe Thr Leu Asn Lys Ser Arg Ile Pro Val Ser Val Ile 225 230 235 240 acg tgg atc atc gcg ttg atc atc acc gcc gcc ccg ctg ctg ggt ctg 768 Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala Ala Pro Leu Leu Gly Leu 245 250 255 gca tao aga gca tta ctg cot 900 cca ggt 798 Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly 260 265 <210> 376 <211> 266 <212> PRT <213> Corynebacterium giutamicun <400> 376 Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr Thr Val Leu Ser Ala Val 1 5 10 Gly Ala Thr Ile Ile Gly Thr Ile Met Ala Leu Thr Leu Asp Arg Thr 25 Asp Val Phe Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro Leu 40 Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala Trp Leu Gin Leu Phe Gly 55 Lys Asn Gin Gly Ile Asn Arg Phe Phe Gly Thr Glu Val Trp Asp Ile 70 75 Tyr Gly Ala Asp Gly Val Thr Phe Leu Leu Ile Val His Ser Tyr Pro 90 Thr Val Tyr Ile Ile Val Ser Ala Ala Leu Arg Gin Leu Pro Ser Asp 100 105 110 Leu Giu Gin Ala Ala Arg Ile Ala Gly Ala Asp Thr Phe Thr Val Leu 115 120 125 Arg Thr Ile Thr Leu Pro Leu Leu Lys Pro Ala Len Leu Ser Ala Phe 130 135 140 Thr Leu Thr Thr Val Ala Asn Leu Ala Asp Phe Gly Ile Pro Ala Len 145 150 155 160 Leu Giy Ser Pro Ala Arg Phe Gin Thr Leu Ala Thr Met Ile Tyr Arg 165 170 175 Phe Met Gin Ser Gly Thr Val Ser Asn Pro Leu Gin Val Val Ser Thr 180 185 190 Ile Gly Ile Val Leu Leu Phe Leu Gly Ile Ala Ala Val Thr Ala Asp 195 200 205 Tyr Len Val Ser Leu Tyr Ala Ala Ser Lys Leu Gin Asp Ala Gly Thr 210 215 220 Pro His Arg Phe Thr Leu Asn Lys Ser Arg Ile Pro Val Ser Val Ile 225 230 235 240 Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala Ala Pro Leu Leu Gly Len 245 250 255 Ala Tyr Arg Ala Leu Len Pro Ala Pro Gly 260 265 <210> 377 <211> 749 <212> DNA <213> Corynebacterium gintamicum <220> <221> CDS <222> (726) <223> RXN01285 <400> 377 ctc aac gtc acc atc ccc gac aac acc ttc acc gcc atc atc ggc ccc 48 Leu Asn Val Thr Ile Pro Asp Asn Thr Phe Thr Ala Ile Ile Gly Pro 1 5 10 aac ggc tgc ggc aaa tcc acc ctg ctc cgc ggt ttc tcc cgc gtg ctc 96 Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Gly Phe Ser Arg Val Leu 25 aat ccg cag cac ggc aaa gtg ctt ctc gac ggt cgg caa ctc gat tca 144 Asn Pro Gin His Gly Lys Val Len Len Asp Gly Arg Gin Len Asp Ser 40 ttc aag cct aaa gaq atc qcc cqa qaa cta ggc ctq ctg cca cag acc 192 Phe Lys Pro Lys Gin Ile Ala Arg Gin Leu Gly Len Len Pro Gin Thr 55 tcc atc gcc cca gaa ggc atc cgg gtt tac gat ctc atc gcg cgc ggg 240 Ser Ile Ala Pro Gin Giy Ile Arg Val Tyr Asp Len Ile Ala Arg Gly 70 75 cgc gct ccc tac Arg Ala Pro Tyr agc ctc ata caa Ser Leu Ile Gin tgg cgc acc tcc Trp Arg Thr Ser gac gaa Asp Giu gac gcc gtc Asp Ala Val gct cgc ctc Aia Arg Leu 115 caa gcg ctc Gin Ala Leu 9CC tcc Ala Ser 105 acg aat ctc acc Thr Asn Leu Thr gaa ctt gca Glu Leu Ala 110 cga gtg tgg Arg Val Trp gtc gat gaa ctc Val Asp Glu Leu gqt ggc cag cgc Gly Gly Gln Arg gtg gcc Val Ala 130 atg ttg ctc gcc Met Leu Leu Ala caa aca ccg atc Gin Thr Pro Ile atg ctt ctc gac gag Met Leu Leu Asp Giu 140 gaa ctc ttg gaa ttg Glu Leu Leu Glu Leu acc acc ttc ctc Thr Thr Phe Leu gac As p 150 atc gcc cac caa Ile Ala His Gin tac Tyr 155 ctg cgc gca ttc Leu Arg Ala Phe gag gcc ggg aaa Giu Ala Gly Lys gtg qtc act gtg Val Val Thr Val ctt cac Leu His 175 gat ctc aac Asp Leu Asn gat ggg cac Asp Gly His 195 caa Gin 180 gcc gcc cgc tac Ala Ala Arg Tyr 9CC Ala 185 gac cac ctc atc Asp His Leu Ile gtg atg aaa. Val Met Lys 190 tta act gcc Leu Thr Ala gta cat gcc acg Val His Ala Thr aca ccg gag qaa Thr Pro Glu Giu gag atg Giu Met 210 gtt caa gga gtt Val Gin Gly Val ggc ctg ccc tgc Gly Leu Pro Cys atc tcc cca gac Ile Ser Pro Asp 672 720 gtc aca gga acc Val Thr Gly Thr ccc Pro 230 acc gtc gtt ccc Thr Val Val Pro ct C Leu 235 agt cgg tct cgc Ser Arg Ser Arg qca Al a 240 gga gct Gly Ala taaqtagcta cccctccaac gga 749 <210> 378 cz211> 242 (212> PRT <213> Corynebacterium glutamicum (400> 378 Leu Asn Val Thr Ile Pro Asp Asn Thr 1 5 Asn Gly Cys Gly Lys Ser Thr Leu Leu 25 Asn Pro Gin His Gly Lys Val Leu Leu 40 Thr Ala Ile Ile Gly Pro Arg Gly Phe Ser Arg Val Leu Leu Asp Ser Asp Gly Arg Gin Phe Lys Pro Lys Giu Ile Ala Arg Giu Leu Gly Leu Leu Pro Gin Thr 55 Ser Ile Ala Pro Giu Gly Ile Arg Val Tyr Asp Leu Ile Ala Arg Gly 70 75 Arg Ala Pro Tyr Gin Ser Leu Ile Gin Gin Trp Arg Thr Ser Asp Giu 90 Asp Ala Val Ala Gin Ala Leu Ala Ser Thr Asn Leu Thr Giu Leu Ala 100 .105 110 Ala Arq Leu Val Asp Giu Leu Ser Gly Gly Gin Arg Gin Arg Val Trp 115 120 125 Val Ala Met Leu Leu Ala Gin Gin Thr Pro Ile Met Leu Leu Asp Giu 130 135 140 Pro Thr Thr Phe Leu Asp Ile Ala His Gin Tyr Giu Leu Leu Giu Leu 145 150 155 160 Leu Arq Ala Phe Asn Giu Ala Gly Lys Thr Val Val Thr Val Leu His 165 170 175 Asp Leu Asn Gin Ala Ala Arq Tyr Ala Asp His Leu Ile Val Met Lys 180 .185 190 Asp Gly His Val His Ala Thr Gly Thr Pro Giu Giu Val Leu Thr Ala 195 200 205 Giu Met Val Gin Gly Val Phe Gly Leu Pro Cys Ile Ile Ser Pro Asp 210 215 220 Pro Val Thr Gly Thr Pro Thr Val Val Pro Leu Ser Arg Ser Arg Ala 225 230 235 240 Gly Ala <210> 379 <211> 1149 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(1126) <223> RXN00523 <400> 379 tqgtgactcg tccqagtgaa attgccgtgq gcatcatcat gccgatcatt qqtgcqccac tgtttatttg gattattcgt cgtcagaaag tcaaagagct atq ago ctt agc cat 115 Met Ser Leu Ser His 1 caa ctc aaq cgc cag cgc gca tcg cgc aac too cgc aqq tgg ctg att 163 Gin Leu Lys Arg Gin Arg Ala Ser Arg Asn Ser Arg Arg Trp Leu Ile 15 gtt gcg gca Val Ala Ala atg tgg ggc Met Trp Gly ttg Leu ggc gtc gto acg Gly Val Val Thr ott Leu 30 ggt att ttt gct Gly Ile Phe Ala ttt tot ttg Phe Ser Leu aaa gtg ttg Lys Val Leu gag gtg ttt tat Gin Val Phe Tyr cot got cag gtg Pro Ala Gin Val ct g Leu tot gga Ser Gly oag cag gjtt coo Gin Gin Val Pro ggo Gly gog agt tat too Ala Ser Tyr Ser ggo gtg ttg ogt Giy Val Leu Arg ocg cgc gog gtg Pro Arg Ala Val ggt ttg act gog Gly Leu Thr Ala ggt Gly ttg gog ttt ggc Leu Ala Phe Gly gog ggc gtg att Ala Gly Val Ile ttt The cag aog gtg ttg Gin Thr Val Leu aat cag ttg gog Asn Gin Leu Ala tog cog Ser Pro 100 gat att ato Asp Ile Ile att gtg ttt Ile Val Phe 120 att tot tot ggc Ile Ser Ser Gly tog gog gog ggo Ser Ala Ala Gly gta att tgo Val Ile Oys 115 att tot ttg Ile Ser Leu tto ggg atg tog Phe Gly Met Ser cag Gin 125 tot gca gtg tog Ser Ala Val Ser tgt gog Cys Ala 135 too ttg gct gtg Ser Len Ala Val ttg ttg att, tat Len Leu Ile Tyr otg Leu 145 gtg gog tat ogo Val Ala Tyr Arg ggt Gly 150 ggt ttt tog gc Gly Phe Ser Ala acg Thr 155 oqt otg att ott Arg Len Ile Leu aco Thr- 160 qgc att ggt att Gly Ile Gly Ile gog atg ctg aat Ala Met Len Asn tta gtg tog tat Len Val Ser Tyr ctg too aag got Len Ser Lys Ala gat tot Asp Ser 180 547 595 643 691 739 tgg gat ctg Trp Asp Len gog aog tgg Ala Thr Trp 200 aco gog aog ogo Thr Ala Thr Arg ott aco ggc tog Len Thr Gly Ser oto aat ggt Len Asn Gly 195 gtg gta oto Val Val Len gat cgt gog atg Asp Arg Ala Met cog Pro 205 otg att gtc aco Len Ile Val Thr att cog Ile Pro 215 ctg ctg gtg got Len Len Val Ala gog ogo aat gtg Ala Arg Asn Val gat Asp 225 ott atg cgt ttg Len Met Arg Leu ggc Gly 230 aat gat too gog Asn Asp Ser Ala gt g Val1 235 ggt ttg ggc gtt Gly Len Gly Val act aat ogo aog Thr Asn Arg Thr 787 835 883 gto att gog att Val Ile Ala Ile goc got gtt gcg Ala Ala Val Ala ato goc gtt got Ile Ala Val Ala aco got Thr Ala 260 goa tgc ggo cog ato gca tto gtg gcg ttt gtg tot ggc cco att. gc Ala Cys Gly Pro Ile Ala Phe Val Ala Phe Val Ser Gly Pro Ile Ala 265 270 275 gcq cgc att tta ggc tcc qqc gga tcg ctc atc atc ccc tcc qca ctc 979 Ala Arg Ile Leu Gly Ser Gly Gly Ser Leu Ile Ile Pro Ser Ala Leu 280 285 290 atc ggc ggg ttg atc gtg ctc atc gcc qac cta att ggc caa tac ttc 1027 Ile Gly Giy Leu Ile Val Leu Ile Ala Asp Leu Ile Gly Gln Tyr Phe 295 300 305 ctc ggc acc cgc tac ccc gtc gga gtt gtc acc ggc gca ttc ggc gcc 1075 Leu Giy Thr Arg Tyr Pro Val Giy Val Vai Thr Gly Ala Phe Gly Ala 310 315 320 325 cca ttc ctt atc tat tta ctc att cgt tcc aac cgc gcg qga gta acc 1123 Pro Phe Leu Ile Tyr Leu Leu Ile Arg Ser Asn Arg Ala Gly Val Thr 330 335 340 ctg tgaccaccaa ccatcaacta tcc 1149 Leu <210> 380 <211> 342 <212> PRT <213> Corynebacterium giutamicum <400> 380 Met Ser Leu Ser His Gin Leu Lys Arg Gin Ary Ala Ser Arq Asn Ser 1 5 10 Arg Arg Trp Leu Ile Val Ala Ala Leu Gly Val Vai Thr Leu Gly Ile 25 Phe Ala Phe Ser Leu Met Trp Gly Giu Val Phe Tyr Gly Pro Ala Gin 40 Val Leu Lys Val Leu Ser Gly Gin Gin Val Pro Gly Ala Ser Tyr Ser 55 Val Gly Val Leu Arg Leu Pro Arq Ala Val Met Gly Leu Thr Ala Giy 70 75 Leu Ala Phe Gly Ala Ala Gly Val Ile Phe Gin Thr Val Leu Arg Asn 90 Gin Leu Ala Ser Pro Asp Ile Ile Gly Ile Ser Ser Gly Ala Ser Ala 100 105 110 Ala Gly Val Ile Cys Ile Val Phe Phe Gly Met Ser Gin Ser Ala Val 115 120 125 Ser Ala Ile Ser Leu Cys Ala Ser Leu Ala Vai Ala Leu Leu Ile Tyr 130 135 140 Leu Val Ala Tyr Arg Gly Gly Phe Ser Ala Thr Arg Leu Ile Leu Thr 145 150 155 160 Gly Ile Gly Ile Ala Ala Met Leu Asn Ser Leu Vai Ser Tyr Ser Leu 165 170 175 Ser Trp Asp Leu Pro Thr Ala Thr Arg Trp Leu Thr Ser Giy Thr Asp 225 Thr Ala Ser Ile Ile 305 Gly Arg Ala Leu 195 Val1 Met Arg Al a Pro 275 Ser Gin Phe Gly Asp 180 Asn Vai Arg Thr Thr 260 Ile Al a Tyr Gly Vai 340 Gly Leu Leu Arg 245 Ala Ala Leu Phe Ala 325 Thr Al a Ile Gi y 230 Val1 Al a Al a Ile Leu 310 Pro Le u Trp 200 Leu Asp Ala Giy Ile 280 Giy Thr Leu Asp Leu Se r Ile Pro 265 Leu Leu Arg Ile Aila Ala Val1 235 Al a Al a Ser Val1 Pro 315 Le u Met Asn 220 Giy Al a Phe Gly Leu 300 Val1 Le u Pro 205 Ala Leu Val Val1 Gly 285 Ile Gly Ile 190 Leu Arg Gly Ala Al a 270 Se r Al a Val1 Arg Ile Asn ValI Leu 255 Phe Le u Asp Val1 Ser 335 <210> 381 <211> 621 <212> DNA <213> Corynebacterium glutarnicum <220> <221> CDS <222> (101)..(598) <223> RXN01142 <400> 381 ctccccatcc accqgcacaq tcagcgcagq caacgaagaa attaaaggac caggacctga ccgagqcatg gttttccaag accacqccct cctgccctga ttg acc gca cgc ggc 115 Leu Thr Ala Arg Gly 1 aac atc gac ttc ggq ctc cgc tcc qcg cgc ccc tcc ttg agc aaa acc 163 Asn Ile Asp Phe Gly Leu Arg Ser Ala Arg Pro Ser Leu Ser Lys Thr 15 qaa cgc gcc gac atc acc cgc acc cac ctc gaa caa gta ggc ctc acc 211 Giu Arg Ala Asp Ile Thr Arg Thr His Leu Glu Gin Vai Gly Leu Thr 30 gac gcc gcc Asp Ala Ala gaa cgg cgc ccc Giu Arg Arg Pro cgc ctc tcc ggc Arg Leu Ser Gly atg caa cag Met Gin Gin 259 cga gtc Arg Val ggc atc gca cgc Gly Ile Ala Arg gcc Al a 60 ttc gcc atc gac Plie Ala Ile Asp cca Pro cca atc atg ctt Pro Ile Met Leu gac gaa ccc ttc Asp Giu Pro Phe gcc ctc gac gcc Aia Leu Asp Ala acc cgc cgc gaa Thr Arg Arg Glu Ct C Le u cag ctc caa cta Gin Leu Gin Leu ct C Le u aac att tgg gaa Asn Ile Trp Glu gcc Al a 95 tcc cgc cgc acc Ser Arq Arg Thr gtc qtc Val Val 100 atg gtc acc Met Val Thr ctc gtg atg Leu Val Met 120 gac gtc gac gag Asp Val Asp Gin atc ctg ctc tcc Ile Len Leu Ser gac cga gtt Asp Arg Val 115 gat att cca Asp Ile Pro tcc aaq agc ccc Ser Lys Ser Pro gaa Glu 125 gcc acc atc atc Ala Thr Ile Ile acc Thr 130 gtg aat Val Asn 135 ctt ccc cgc ccc Leu Pro Arg Pro cac gag ctg agt His Glu Leu Ser gac gct tct gtt Asp Ala Ser Val ga a Glu 150 ca c His gcc gag acc aca Ala Gin Thr Thr gcc Ala 155 ctg cgt aag cgg Len Arg Lys Arg atg Met 160 ctg cat ctg ctg Len His Len Leu gag Giu 165 tagtttctaa cacgtctttt aaa <210> 382 <211> 166 <212> PRT <213> Corynebacterium glutamicun <400> 382 Leu Thr Ala Arg Gly 1 5 Asn Ile Asp Phe Leu Arg Ser Ala Arq Pro Ser Leu Ser Gin Val Gly Giy Gly Met Thr Giu Arg Ala Asp Ile Thr Arg Leu Thr Asp Ala Giu Arg Arg Pro Thr His Leu Gin Ala'Arg Len Ser Phe Ala Ile Asp Gin Gin Arg Gly Ile Ala Arg Pro Pro Ile Met Len Leu 70 Asp Glu Pro Phe Gly Ala Leu Asp Ala Thr Arg Arg Gln Leu Gin Leu Gin Leu Len 90 Asn Ile Trp Glu Ala Ser Arg Leu Ile Glu 145 Leu Thr Asp 115 Asp Ala Leu Val1 100 Arg Ile Ser Leu Met Leu Val1 Glu 150 His Val Thr His Asp Val Asp Glu Ala Ile Leu 105 110 Val Met Ser Lys Ser Pro Glu Ala Thr Ile 120 125 Asn Leu Pro Arg Pro Arg His Glu Leu Ser 1375 140 Ala Glu Thr Thr Ala Leu Arg Lys Arg Met 155 160 <z210> 383 (211> 948 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (925) <223>' RXN01141 (400> 383 aaagaacact cggtatggca cctgatttaa ggatgctgca atcgtgacac atatcctctt cgacaqcagg cgttttctgc aactgggcgc ttttgcgtcc ttg agc acc gca ttg Leu Ser Thr Ala Leu 9CC Al a ga t Asp ccg Pro aat As n tat Tyr gtg Val1 gga gcg Gly Ala aac act Asn Thr att gct Ile Ala gtc acq Val Thr gca aca Ala Thr gcg att Ala Ile gcc Ala ccc Pro atc Ile ttg Le u gag Glu aat Asn tac T yr acc Thr gat Asp aag Lys ct t Le u 75 gga Gly qt q Val1 att Ile gcg Al a tac Tyr ga t Asp gtg Val1 t cg Ser tac Tyr 30 ggg Gi y ggc Gi y gcg Al a aac As n agc Ser cct Pro ttt Phe tcc Ser atg Met 80 t cg Ser ga a Glu gg c Gi y ca c His tgg Trp ccg Pro acg Thr 9cg Ala gcg Ala gtg Val gcc Ala act Thr ctg Leu tcg ttt acc cag aac acc aat ggg caa Ser Phe Thr Gin Asn Thr Asn Gly Gin 105 110 att acc ttq Ile Thr Leu gcq tca aag Ala Ser Lys 115 cac tat ggt His Tyr Gly 120 tcc gtc aat tca gcq gcg gat ctt aaa Ser Val Asn Ser Ala Ala Asp Leu Lys ggc Gly 130 atg gtg ctg Met Val Leu gga att Gly Ile 135 cct ttt gaa tat Pro Phe Glu Tyr tca Se r 140 gtc cat gcg ctg Val His Ala Leu ctg cgc gat tat Leu Arg Asp Tyr ctc Leu 150 gtc tca aac gca Val Ser Asn Ala gat ccc atc gcc Asp Pro Ile Ala gat Asp 160 ctt gag ctt cgc Leu Giu Leu Arg ctc cga cct gcc Leu Arg Pro Ala ga t Asp 170 atg qtc gca caa Met Val Ala Gin aca gtt gag ggc Thr Val Gin Gly atc gat Ile Asp 180 gga ttc att Gly Phe Ile tcc ggc cgg Ser Gly Arg 200 cct ggg ccg ttt Pro Gly Pro Phe aat As n 190 gaa cgc gcc atc Giu Arg Ala Ile agc aat ggc Ser Asn Gly 195 aaa cat cca Lys His Pro att tgg ctg ctg Ile Trp Leu Leu aaa caa ctg tgg Lys Gin Leu Trp tgc tgc Cys Cys 215 gcc gtg gcg atg Ala Val Ala Met aaa gag tgg aaa Lys Giu Trp Lys gct Ala 225 gaa cac ccc acg Glu His Pro Thr 691 739 787 835 883 gct cag qgt gtg Ala Gin Gly Val aat gcg ctg gag Asn Ala Leu Gin gcc tcc gca att Ala Ser Ala Ile agc aat ccg gca Ser Asn Pro Ala ttt gat tcc tcg Phe Asp Ser Ser gca Ala 255 cgc acg ctg tcg Arg Thr Leu Ser cag gaa Gin Giu 260 aaa tac ctc Lys Tyr Leu aac Asn 265 cag cct gcc acg Gin Pro Ala Thr ttg Len 270 ctg gat gga ccg Leu Asp Gly Pro t cg Ser 27 taatcatcgg catcaccggc tta <210> 384 <211> 275 <212> PRT <213> Corynebacterium giutarnicum <400> 384 Leu Ser Thr Ala Len Ala Gly Ala Ala Arg 1 5 10 Tyr Val Thr Ser Thr Ser Asn Asn Giu Pro Ala Asp Asn Thr Pro 25 Ile Ala Gly Ser Ala Pro Ile Ala Ile 40 Leu Thr Ile Gly Tyr Val Pro Gly Len Phe Ala Asp Ala Le u Lys Lys His Gly Val Asn Val Thr Len Lys Lys Tyr 55 Ser Gly Trp Ser Asp Leu Trp Thr Ala Tyr Ala Thr Glu Gin Leu. Asp Val Ala His Met 70 75 Leu Ser Pro Met Thr Val Ala Ile Asn Ala Gly Val Thr Asn Ala Ser 90 Arg Pro Thr Glu Leu Ser Phe Thr Gin Asn Thr Asn Gly Gin Ala Ile 100 105 110 Thr Leu Ala Ser Lys His Tyr Gly Ser Val Asn Ser Ala Ala Asp Leu 115 120 125 Lys Gly Met Val Leu Gly Ile Pro Phe Giu Tyr Ser Val His Ala Leu 130 135 140 Leu Leu Arg Asp Tyr Leu Val Ser Asn Ala Val Asp Pro Ile Ala Asp 145 150 155 160 Leu Giu Leu Arg Leu Leu Arg Pro Ala Asp Met Val Ala Gin Leu Thr 165 170 175 Val Glu Gly Ile Asp Gly Phe Ile Gly Pro Gly Pro Phe Asn Glu Arg 180 185 190 Ala Ile Ser Asn Gly Ser Gly Arg Ile Trp Leu Leu Thr Lys Gin Leu 195 200 205 Trp Asp Lys His Pro Cys Cys Ala Val Ala Met Ala Lys Giu Trp Lys 210 215 220 Ala Glu His Pro Thr Ala Ala Gin Gly Val Leu Asn Ala Leu Giu Giu 225 230 235 240 Ala Ser Ala Ile Leu Ser Asn Pro Ala Gin Phe Asp Ser Ser Ala Arq 245 250 255 Thr Leu Ser Gin Giu Lys Tyr Leu Asn Gin Pro Ala Thr Leu Leu Asp 260 265 270 Gly Pro Ser 275 <210> 385 (211> 927 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (904) <223> RXN01002 <400> 385 gactgctgat accgcacagg atgaaatcac tcgttacggc gagatcctga agaagttctc caactaattt ccctgtttcc aatactcaaq gtqtgcqcat atg aat tct gat gct 115 Met Asn Ser Asp Ala 1 tcg gct acc acc aac tcc tgq gct atc aac ttc gac cat gtg tcg gtg 163 Ser acg Thr aat Asn t CC Ser acc T hr ctg Le u ctg Leu gcg Ala ga C Asp aaa Lys 150 gt t Val gat Asp coc Arg aac Asn ggt Gly 230 acc Thr Ala tat Tyr CCC Pro a cg Thr gtg Val1 cgt Arg t Cg Ser cac His aag Lys 135 gtg Val gct Al a gag Glu ga t Asp ttg Leu 215 ttg Le u ga t Asp Thr CCC Pro ggt Gly ctg Le u acg Thr ga t Asp gaa Giu aca Thr 120 ca o Gin t gg Trp att Ile CCt Pro Ct a Leu 200 Cac His Cgt Arg aaa Lys Thr aa t As n gag Glu att Ile gtg ValI gcc Ala CgC Arg 105 gcg Al a att Ile aCC Th r gcg Ala gt g Val1 185 ga a Gi u ttg Leu gcc Ala ga C Asp Asn 9gg Gly a tg Met Cg C Arg ggg Gly Cot Arg agc Se r t gg Trp gCt Aia cga Arg CgC Arg 170 gca Ala aac As n att Ile gyc r Gly ttt Ph e Trp aaa Lys gcc Al a atc Ile 60 cat His ca g Gin gtg Val1 Cgt Arg cac His 140 ggt Gly tta Leu Ctt Leu aac As n ttg Leu 220 Ctg Leu gct Ala Ala 0C Ala atc Ile 45 aac Asn cag Gin atc Ile ttC Phe aac As n 125 gcg Al a gct Ala t Cg Ser gat Asp aac As n 205 gct Ala gtC Val1 atc Ile Ile ct C Le u 30 gt g Val1 ggt Gly at C Ile gg C Gi y Ca 0 Gin 110 ct C Leo ttg Le u ttg Le u ca a Gin cCg Pro 190 gtg Val1 Cgt Arg tat T yr tat Tyr As n 15 ga t Asp ggt Gly Ct t Leo aac Asn atg Met 95 aat As n ctc Leu gag Giu t cg Ser gat Asp 175 cca Pro gaa Glu caa Gin gac Asp gqt Gly Phe ga t Asp ct g Leu gtC ValI acc Thr 80 at t Ile gt t Val1 09 Gly tcC Se r ggt Gly 160 CCg Pro acc Thr qoc Gly tac Tyr ggt Gly 240 CC Arg Asp gtt Val1 tca Ser cgc Arg ttg Leu ttc Phe ttg Leu ttt Phe gtg Vai 145 gga Gly tct Ser gcg Al a ct C Leu acc Thr 225 CCt Pro CCC Pro His tcC Ser gga Gly gct Ala a ag Lys cag Gin gtg Val CCC Pro 130 Giy cag Gin gt C ValI cat His acc Thr 210 aca Thr atc Ile atc Ile Val1 ctc Leu tcg Ser a cg Thr 000 Gly qgg Gly gq C Gly 115 acg Thr att Ile aaa Lys atg Met tC Ser 195 gtg Val1 agg Arg tct Ser cag Gin Ser acc Thr got Gi y gaa Glu aaa Lys ttC Phe 100 CgC Arg gag Glu ttg Leu cag Gin Ct g Leo 180 gtg ValI ttg Leu Ctt Leu gag Glu gct Al a Val1 atc Ile aaa Lys ggC Gly gca Ala aac Asn ttc Phe Cac His Cac His CC Arg 165 gca Al a atg Met gtg Val1 gtg ValI gCC Al a 245 aaa Ly s 211 259 307 355 403 451 499 547 595 643 691 739 787 835 883 250 255 gac ctg cta ggt gat cgc gca tgaccacgcc ttcttctaca ctt Asp Leu Leu Gly Asp Arq Ala <210> 386 <211> 268 <212> PRT (213> Corynebacterium glutamicum <400> 386 Met Asn Ser 1 Asp Val1 Ser Arg Leu Phe Leu Phe Val1 145 Gly Ser Ala Leu Thr 225 Pro His Ser Gly Ala Lys Gin Val1 Pro 130 Gly Gin Val1 His Thr 210 Thr Ile Val1 Le u Se r Thr Gi y Gly Gly 115 Thr Ile Lys Met Se r 195 Val1 Arg Ser Asp Ser Thr Gly Glu Lys Phe 100 Arg Giu Le u Gin Leu 180 Vali Leu Leu Glu Ala Ser Ala 5 Val Thr Tyr Ile Asn Pro Lys Ser Thr 55 Gly Thr Val 70 Ala Leu Arg Asn Leu Ser Phe Ala His His Asp Lys 135 His Lys Val 150 Arg Val Ala 165 Ala Asp Giu Met Arg Asp Val Asn Leu 215 Val Gly Leu 230 Ala Thr Asp 245 Thr Pro Gly 40 Leu Thr Asp Glu Thr 120 Gin Trp Ile Pro Leu 200 His Arg Lys Thr As n 25 Gi u Ile Val1 Al a Arg 105 Al a Ile Thr Al a Val1 185 Glu Leu Ala Asp Asn 10 Gly Met Arg Giy Arg 90 Ser T rp Ala Arg Arg 170 Ala Asn Ile Gly Phe 250 Ser Thr Val1 Thr Pro 75 Gly S er Trp Phe Ala 155 Aia Ser Ile Asp Lys 235 Glu T rp Lys Ala Ile His Gin Val Arg His 140 Gly Leu Leu As n Leu 220 Leu Al a Ala Ala Ile As n Gin Ile Phe Asn 125 Aila Ala Ser Asp Asn 205 Al a Val1 Ile Ile Le u Val1 Gly Ile Gi y Gin 110 Le u Le u Leu Gin Pro 190 Val1 Arg Tyr Tyr As n Asp Gly Leu Asn Met As n Leu Giu Ser Asp 175 Pro Giu Gin Asp Gly 255 Phe Asp Leu Val1 Thr Ile Val1 Gly Ser Gly 160 Pro Thr Gly Tyr Giy 240 Arg Pro Ile Gin Ala Lys Asp Leu Leu Gly Asp Arg Ala 260 265 <210> 387 <211> 969 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101) (94 6) <223> RXN01000 <400> 387 ctttctatgc ctacgcggat gtttccgtga tcattctgqa aatcctcatc gtggtgattg tcattgaagt aatctccaac gcacttcgaa agaggctggt atg agc acc tta acc Met Ser Thr Leu Thr tct cac Ser His aaa ctg Lys Leu ata gct Ile Ala ccc gcg Pro Ala tgg tcg Trp Ser atg gcg Met Ala gga atg Gly Met tta cgg Leu Arg gca att Ala Ile 135 cgc Arg gog Ala acc Thr cag Gin aag Lys tg Trp ttg Leu t tc Phe 120 att Ile aca Th r cg c Arg ggc Gi y gtg Val1 ttt Phe ttg Leu gct Ala 105 gtg Val1 tt g Le u cg Pro atc Ile ctc Le u cat His cgc Arg 75 9CC Ala cgc Arg gcg Ala act Thr ccc Pro gca Al a atc Ile 45 t ta Le u gt c Val tta Leu gtg Val1 att Ile 125 acc Thr agc Ser att 1ie 30 gag Ci u gag Giu cag Gin tgc Cys gga Gly 110 cg t Arg ggc Gly Ccc Pro gct Ala aat As n atg Met atg Met 80 gt g Val1 tat Tyr ttc Phe act Thr 1 Ccg Pro gcg Ala gag Glu ttt Phe tgg T rp gtc Val1 tgg T rp ccc Pro cct Pro 145 gcg Ala ctg Leu ctt Leu agc Ser cg t Arg tct Ser ctq Leu ga a Giu 130 ttt Phe cqc Arg att Ile ccg Pro ga t Asp tcc Ser gt c Val1 cqt Arg 115 gtg Val1 act Thr ccc aac Pro Asn gtc ctt Val Leu cag atg Gin Met ccc gat Pro Asp atc gcc Ile Ala cct ctg Pro Leu 100 acc gtt Thr Val qtt atc Val Ile qgt gcg Gly Ala 115 163 211 259 307 355 403 451 499 547 595 ctc gca ttg ggt atc tcc ggt att gga caa cag qca aag tgg acc tat Leu Ala Leu Gly Ile Ser Gly Ile Gly Gin Gin Ala Lys Trp Thr Tyr 150 155 160 165 gaa qcc att gag tcc act ccc acc qqc ccq Glu Ala Ile Glu Ser Thr Pro Thr Gly Pro 170 175 gcg ggt gga act acg ccg gag gtt ctg cgg Ala Gly Gly Thr Thr Pro Glu Val Leu Arg 185 190 gtt gcg cca tcc att gca tct ttt gcc ctq Val Ala Pro Ser Ile Ala Ser Phe Ala Leu 200 205 atc cgt acc tct gcg gta ttg ggc atc gtt Ile Arg Thr Ser Ala Val Leu Gly Ile Val 215 220 agt atg ctt gcc aat tac: acc aac tac agg Ser Met Leu Ala Asn Tyr Thr Asn Tyr Arg 230 235 atg ctg ctc atc gtc gtg gtt gtc qca acg Met Leu Leu Ile Val Val Val Val Ala Thr 250 255 tcc ggc acc atc cgc cgc cgc atc atg aag Ser Gly Thr Ile Arg Arg Arg Ile Met Lys 265 270 gtg qca cca agc aac tgacgctcca ccaaqcat Val Ala Pro Ser Asn 280 <210> 388 (211> 282 '<212> PRT <213> Corynebacterium glutamicun <400> 388 Met Ser Thr Leu Thr Ser His Arg Thr Val 1 5 10 Pro Ala Arg Pro Asn Lys Leu Ala Arg Asn Ala Leu Ile Val Leu Ile Ala Thr Gly Thr 40 Glu Leu Pro Gin Met Pro Ala Gin Val Trp 55 Phe Ser Asp Pro Asp Trp Ser Lys Phe Gly Trp Arg Ser Ile Ala Met Ala Trp Leu Gly 90 Val Ser Val Pro Leu Giy Met Leu Ala Ala 100 105 Trp Leu Arg Thr Val Leu Arg Phe Vai Phe t ca Ser tgg Trp tac T yr ggt Gly cag Gin 240 atg Met ggq Gi y g ca Ala ttg Leu ttt Phe 210 ggt Gly gac Asp gtC Val agt Ser gtg ValI t gg Trp 195 gag Glu ggt Gly acc Thr gat Asp gac Asp 275 g ca Ala cag Gin aac Asn gg t Gly ggC Giy 245 atc Ile gtc Val1 cc gca Ala Val1 Ly s Tyr Al a Ile Gly Vali Pro Al a Ile Leu Val1 Leu Val1 Ile Ser ValI Trp Le u Giu Val1 Pro Ala Pro Pro 145 Al a Glu Ala Arg Ala 225 Trp Ile Al a Val1 Gly Th r Arg 180 Pro Ile Ile Val1 Le u 260 Arg Al a Le u 150 Glu Ala Val1 Ile Ser 230 Met Ser Val1 Leu Gly Glu Thr 185 Ser Ser Al a Ile Ile 265 Ser Leu Ile Ser 170 Thr Ile Ala Asn Val1 250 Arg Asn Val1 140 Gly Pro Glu Ser Leu 220 Thr Val1 Ar g Qly Gly Gly Le u 190 Ala Ile Tyr Ala Met 270 Le u Gin Pro 175 Arg Leu Val1 Arg Thr 255 Lys <210> 389 <211> 1173 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1150) <223> RXN01732 <400> 389 gattctatcg ctgatctccc tctccttgcc tgggtttgtt ctttcttgtc tcatgtcgct gaaaggtttt taaagatctc aag cca tcc aag tcc atg cgt gtt gct gtt tct Lys Pro Ser Lys Ser Met Arg Val Ala Val Ser 15 acc ctt gct cta gtt ggt tgt tcc tct tcc gat Thr Leu Ala Leu Val Gly Cys Ser Ser Ser Asp 30 tca tct gcg tct tct tct tcg gat gct gca agc Ser Ser Ala Ser Ser Ser Ser Asp Ala Ala Ser 45 cccgggtctc ctcttcttaa atg ttc aag ctc tct 115 Met Phe Lys Leu Ser 1 ac-g ctt. gcg atc tct 163 Thr Leu Ala Ile Ser gag tct tct tcc tca 211 Glu Ser Ser Ser Ser cAg tgg cct gag tcc 259 Gin Trp Pro Glu Ser att act Ile Thr ttg tct ctt gtt Leu Ser Leu Val. tct act gag ggt Ser Thr Glu Gly gat ttg gct gaa Asp Leu Ala Giu ttg gct cct ttg Leu Ala Pro Leu act Thr gat tac ctg tct Asp Tyr Leu Ser gag Giu 80 aac ctt ggt att Asn Leu Gly Ile gag Glu gtc aat qgt gtg Val Asn Gly Val gcg tct gat tac Ala Ser Asp Tyr gca acc gtt gag Ala Thr Val Glu gct ttg Ala Leu 100 ggt gct gat Gly Ala Asp aac gcg att Asn Ala Ile 120 cag Gin 105 qct cag gtq atc Ala Gin Val Ile act gat gcg ggt Thr Asp Aia Gly tcc ctg tat Ser Leu Tyr 115 gat gtg cgt Asp Val Ary gag cag tac gat Giu Gin Tyr Asp gcg Ala 125 cag ctg att ctg Gin Leu Ile Leu cg t Arg 130 ttc ggt Phe Giy 135 gcc acc tcg tac Ala Thr Ser Tyr gct gtg gcg tac Ala Val Ala Tyr aac aat cct gat Asn Asn Pro Asp tac tgc gac gat Tyr Cys Asp Asp gcc Al a 155 cca gtg gct gcg Pro Val Ala Ala tct. Ser 160 tat gct gcg tcc Tyr Ala Ala Ser gat Asp 165 gta gac atg ctt Val Asp Met Leu tgc aac ggt att Cys Asn Gly Ile act gag ggc cag Thr Glu Gly Gin gct gct Ala Ala 180 acc ggt gag Thr Gly Giu ggt gac aag Gly Asp Lys 200 gg c Gl y 185 cca gca gct ctt Pro Ala Ala Leu gcg ctg gaa aag Ala Leu Glu Lys atc gag tcc Ile Giu Ser 195 ggt tac cag Gly Tyr Gin 691 739 gta gcg ctg cag Val Ala Leu Gin gct Ala 205 gca acc tct cct Ala Thr Ser Pro gcg Ala 210 tac cct Tyr Pro 215 atc gtc gct atg Ile Val Ala Met gat ctq ggc atg Asp Leu Gly Met acc gat tcc qct Thr Asp Ser Ala ttt Phe 230 gtt cag gtt cca Val Gin Val Pro gta Val1 235 gag ggc aac aac Glu Gly Asn Asn gCt gtg ctg tct Ala Val Leu Ser 787 835 883 ctg aac ggt gac Leu Asn Gly Asp gaa gtg tcc ttc Giu Val Ser Phe ggt Gly 255 ttc tgg gat gcg Phe Trp Asp Ala cgt tcc Arg Ser 260 acc gtg ctg Thr Val Leu gcc tac acc Ala Tyr Thr 280 t ct Ser 265 gag gct cct aac Giu Ala Pro Asn gct gag gat gtc Ala Giu Asp Val gta gcg ttt Val Ala Phe 275 tcc aag tcc Ser Lys Ser gag atg atc cct Glu Met Ile Pro ggt ggc gtc gca Gly Gly Val Ala gcg Ala 290 ctt cca tec gac ctg gtg gaa aag ctc acc gag ttg atg gat gat tac 1027 Leu Pro Ser Asp Leu Val Glu Lys Leu Thr Glu Leu Met Asp Asp Tyr 295 300 305 gca gat tc tcc gag gaa gcc aag gat gtc atg ttc gac atg gtt ggt 1075 Ala Asp Ser Ser Glu Glu Ala Lys Asp Val Met Phe Asp Met Val Gly 310 315 320 325 cta tct gac tgg act gct gat acc gca cag gat gaa atc act cgt tac 1123 Leu Ser Asp Trp Thr Ala Asp Thr Ala Gin Asp Glu Ile Thr Arg Tyr 330 335 340 ggc gag atc ctg aag aag ttc tec aac taatttccct gtttccaata 1170 Gly Glu Ile Leu Lys Lys Phe Ser Asn 345 350 ctc 1173 <210> 390 <211> 350 <212> PRT <213> Corynebacterium glutamicum <400> 390 Met Phe Lys Leu Ser Lys Pro Ser Lys Ser Met Arg Val Ala Val Ser 1 5 10 Thr Leu Ala Ile Ser Thr Leu Ala Leu Val Gly Cys Ser Ser Ser Asp 25 Glu Ser Ser Ser Ser Ser Ser Ala Ser Ser Ser Ser Asp Ala Ala Ser 40 Gin Trp Pro Glu Ser Ile Thr Leu Ser Leu Val Pro Ser Thr Glu Gly 55 Glu Asp Leu Ala Glu Ala Leu Ala Pro Leu Thr Asp Tyr Leu Ser Glu 70 75 Asn Leu Gly Ile Glu Val Asn Gly Val Val Ala Ser Asp Tyr Ala Ala 90 Thr Val Glu Ala Leu Gly Ala Asp Gin Ala Gin Val Ile Ile Thr Asp 100 105 110 Ala Gly Ser Leu Tyr Asn Ala Ile Glu Gin Tyr Asp Ala Gin Leu Ile 115 120 125 Leu Arg Asp Val Arg Phe Gly Ala Thr Ser Tyr Ser Ala Val Ala Tyr 130 135 140 Thr Asn Asn Pro Asp Lys Tyr Cys Asp Asp Ala Pro Val Ala Ala Ser 145 150 155 160 Tyr Ala Ala Ser Asp Val Asp Met Leu Tyr Cys Asn Gly Ile Glu Thr 165 170 175 Glu Gly Gin Ala Ala Thr Gly Glu Gly Pro Ala Ala Leu Asp Ala Leu 180 185 190 Glu Pro As p 225 Ala Trp Asp Ala Le u 305 Phe Glu Ile 195 Gl y Asp Le u Al a Val1 275 Ser Asp Met Thr Ser Gln Ala Val 245 Ser Phe S er T yr Gly 325 Tyr Gly Tyr Phe 230 Le u Thr Al a Le u Al a 310 Le u Gly Lys 200 Ile Gin Gly Leu Thr 280 Ser Se r Asp Ile Val Val1 Val1 Asp Ser 265 Glu Asp Se r Trp Le u 345 Ala Ala Pro Al a 250 Gi u Met Le u Glu Th r 330 Lys Le u Met Val1 235 Giu Al a Ile Val1 Giu 315 Ala Lys Ala 205 Asp Gly Ser Asn Asn 285 Lys Lys Thr Ser Ala Leu As n Phe Al a 270 Gly Le u Asp Al a Asn 350 Ser Met Asn 240 Phe Glu Val1 Glu Met 320 Asp <210> 391 <211> 903 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(880) <223> RXN03080 <400> 391 cttgcaaaca ggcgtggtgq tggcgttcat tggctcacca cagcatgcgc aagcgacgcq qattggggct gtaaaaactc gaa Glu aac As n cca Pro gt t att Ile gtg Val1 aat As n gaa gat Asp ttt Phe gct Ala acc ctc Leu tct Ser ggt Gly ggc gtt Val C ct Pro agt Ser gta ttc Phe 9ga Gly 30 gcc Al a gt t ccc tct Pro Ser 15 aaa gtc Lys Val. ctt tcq Leu Ser gqt ggg attttccttt atttactgct atg cct caa tta gtt Met Pro Gin Leu Val 1 cqc cat gca gtg aaa Arg His Ala Val Lys acc gca Ctg att ggc Thr Ala Leu Ile Gly gcg att gca qqa ttq Ala Ile Ala Gly Leu agt ggg gtt gcg tcg 115 163 211 259 307 Val Glu Ser Thr Gly Glu Val Met Val Gly Gly Ser Gly Val Ala Ser 60 aaa agc gct aaa. gcc cga gcc cgc ctg ctc tca ctc gtg ccg caa aac 355 Lys Ser Ala Lys Ala Arg Ala Arg Leu Leu Ser Leu Val Pro Gin Asn 75 80 acc gag ttg cgc att ggt ttt agt gca cgc gac gtt gtc gcg atg ggc 403 Thr Giu Leu Arg Ile Gly Phe Ser Ala Arg Asp Val Val Ala Met Gly 95 100 cgc tac ccg cat cgt ggc cgc ttc gcc gtg gag acc gac gca. gat cga 451 Arg Tyr Pro His Arg Gly Arg Phe Ala Val Giu Thr Asp Ala Asp Arg 105 110 115 cgc qcc acc gat gac gcc ctg cgc gcc atc aac gcg ctc qac atc gcc 499 Arq Ala Thr Asp Asp Ala Leu Arg Ala Ile Asn Ala Leu Asp Ile Ala 120 125 130 gag cag ccc gtc aac qaa tta tcg ggc ggc cag cag cag ctc atc cac 547 Glu Gin Pro Val Asn Giu Leu Ser Giy Gly Gin Gin Gin Leu Ile His 135 140 145 atc ggc cga gcg ctc gcc caa gac acc gcc gtc gtg ctt ctc gac gag 595 Ile Gly Arg Ala Leu Ala Gin Asp Thr Ala Val Val Leu Leu Asp Giu 150 155 160 165 ccc gtc tcc gcc ctt gat cta cgg cac caa gtt gaa gt:c ctt caa, ctc 643 Pro Vai Ser Ala Leu Asp Leu Arg His Gin Val Giu Val Leu Gin Leu 170 175 180 ctg cgc gcc cga, gct aat tcc ggc acc acc qtq atc gtc gtc ctt cac 691 Leu Arg Ala Arg Ala Asn Ser Gly Thr Thr Val Ile Val. Val. Leu His 185 190 195 gat ctc aac cac gtt gcc cgt tgg tgc gac cat gca. gtg ttg atg gcc 739 Asp Leu Asn His Val Ala Arg Trp Cys Asp His Ala Val Leu Met Ala 200 205 210 gac ggc gaa gtt gtc tcc caa ggt gac atc cgc gag gtg ctc gaa cct 787 Asp Gly Giu Val Val Ser Gin Gly Asp Ile Arg Giu Val Leu Giu Pro 215 220 225 gcc aca ctg tcc acc gtg tac gga ctg ccc att gcg gtg cgc gat gat 835 Ala Thr Leu Ser Thr Val Tyr Gly Leu Pro Ile Ala Val Arg Asp Asp 230 235 240 245 ccc gaa acc agc tca ctt cgc gtg atc ccg cat cca aat ccc ttt 880 Pro Glu Thr Ser Ser Leu Arg Val Ile Pro His Pro Asn Pro Phe 250 255 260 tgattgaaag tttgacttaa aaa. 903 <210> 392 <211> 260 (212> PRT <213> Corynebacterium giutamicum <400> 392 Met Pro Gin Leu Val Giu Ile Arg Asp Leu Asn Val Giu Phe Pro Ser Arg His Ala Val Lys Asn Val Ser Phe Ser Ala Pro Ala Gly Lys Val 25 Thr Ala Leu Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Ala Leu Ser 40 Ala Ile Ala Gly Leu Val Glu Ser Thr Gly Glu Val Met Val Gly Gly 55 Ser Gly Val Ala Ser Lys Ser Ala Lys Ala Arg Ala Arg Leu Leu Ser 70 75 Leu Val Pro Gin Asn Thr Glu Leu Arg Ile Gly Phe Ser Ala Arq Asp 90 Val Val Ala Met Gly Arg Tyr Pro His Arg Gly Arg Phe Ala Val Glu 100 105 110 Thr Asp Ala Asp Arg Arg Ala Thr Asp Asp Ala Leu Arg Ala Ile Asn 115 120 125 Ala Leu Asp Ile Ala Giu Gin Pro Val Asn Giu Leu Ser Gly Giy Gin 130 135 140 Gin Gin Leu Ile His Ile Gly Arg Ala Leu Ala Gin Asp Thr Ala Val 145 150 155 160 Val Leu Leu Asp Glu Pro Val Ser Ala Leu Asp Leu Arg His Gin Val 165 170 175 Glu Val Leu Gin Leu Leu Arg Ala Arg Ala Asn Ser Gly Thr Thr Val 180 185 190 Ile Val Val Leu His Asp Leu Asn His Val Ala Arg Trp Cys Asp His 195 ,200 205 Ala Val Leu Met Ala Asp Gly Glu Val Val Ser Gin Gly Asp Ile Arg 210 215 220 Giu Val Leu Giu Pro Ala Thr Leu Ser Thr Val Tyr Gly Leu Pro Ile 225 230 235 240 Ala Val Arg Asp Asp Pro Giu Thr Ser Ser Leu Arq Val Ile Pro His 245 250 255 Pro Asn Pro Phe 260 <210> 393 (211> 582 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(559) <223> RXN03081 <400> 393 acggactgcc cattgcggtg cgcgatgatc ccgaaaccag atccaaatoc cttttgattg aaagtttgac ttaaaaaccc ctcaottcgc gtgatcccgo atg aaa aaa tca ctc 11. Met Lys Lys Ser Leu 1 atc 9CC att gtt Ile Ala Ile Val agt gcg ctc gtg tta ago ggc tgc acc Ser Ala Leu Val Leu Ser Gly Cys Thr tot gat Ser Asp tot tct gac Ser Ser Asp aca acc ago Thr Thr Ser t ct Ser tcc ggc act tc Ser Gly Thr Ser act gtg gaa acc Thr Val Glu Thr act tog att Thr Ser Ile acc gtc aca Thr Val Thr gtt gcc gca gct Val Ala Ala Ala gac Asp 45 ggc gca ttc cca Gly Ala Phe Pro cq c Arg ctc gao Leu Asp gat tcc tcc atc Asp Ser Ser Ile tta gaa too aaa Leu Giu Ser Lys gag cgc atc gcc Glu Arg Ile Ala gt a Val1 ctc acc cca gag Leu Thr Pro Giu gca tcc ttg gtt Ala Ser Leu Val Ccc atc aca ggc Pro Ile Thr Gly gac cgc gtc gtg Asp Arg Val-Val atg Met aco gcc gaa Thr Ala Glu atg gao Met Asp 95 acc got gao gaa Thr Ala Asp Giu gaa acc Giu Thr 100 gca gct cig Ala Ala Leu ctc gao ccc Leu Asp Pro 120 gCC Al a 105 tcc caa gtg gaa Ser Gln Val Glu caa gtc aaa aac Gin Val Lys Asn 9gt ggC agg Gly Gly Arg 115 qtg atc gto Val Ile Val gaa caa gtt gtc Glu Gin Val Val 900 Ala 125 ggc gao coa gat Gly Asp Pro Asp ttg Le u 130 agt gog Ser Ala 135 cgt ttc gat acc Arg Phe Asp Thr caa ggc aco atc Gin Gly Thr Ile gao As p 145 att ttg gaa 990 Ile Leu Glu Gly Cc Leu 150 aac gto cog Asn Val Pro tagttaactt ogattcagao got <210> 394 <211> 153 <212> PRT (213> Corynebacterium glutamicum <400> 394 Met Lys Lys Ser Leu Ile Ala Ile Val 1 5 Gly Cys Thr Ser Asp Ser Ser Asp Ser 25 Ser Ala Leu Val Leu Ser Ser Gly Thr Ser Gly Thr Val Glu Thr Thr Ser Ile Thr Thr Ser Val Ala Ala Ala Asp Gly Ala Phe 603 40 Pro Arg Thr Val Thr Leu Asp Asp 55 Pro Glu Arg Ile Ala Val Leu Thr 70 Pro Ile Thr Gly Ala Asp Arg Val Ala Asp Glu Glu Thr Ala Ala Leu 100 Lys Asn Giy Gly Arg Leu Asp Pro 115 120 Asp Leu Val Ile Val Ser Ala Arg 130 135 Asp Ile Leu Glu Gly Leu Asn Val 145 150 <210> 395 <211> 444 <212> DNA <213> Corynebacterium glutamicum <220> <221> COS <222> (421) <223> RXN03082 <400> 395 cagaagcaat cgcagaaatc gatgcaaacc ccccactgtg ctcactttga tgcaacgcgg Ser Pro Val Ala 105 Glu Phe Pro Ile Al a Thr Gin Val1 Thr Thr Ala Al a Val Val1 Giu 140 Leu S er Glu Glu Ala 125 Gin gcattcgaca accacgccaa tat Ser gt a Val1 gt t ValI aaa Lys aaa As n gcc Al a gat Asp gt t Val1 Gly gtt Val1 ct a Le u ata Le u atg Met gag Glu gcc Ala ac Thr ggc Gly gca Ala aac Asn att Ile ggc Gly gag Al a act Pro ttc Ph e gaa Giu 75 ata aga Ile Arg gqa ac Gly Thr 30 ata ata Ile Ile aat tta Asn Phe gaa aaq Asp Lys ttagaaaaga ctgaacatc atg gta atg caa gaa Met Val Met Pro Glu 1 gga gga aat aaa gtg Gly Gly Thr Pro Val gaa gaa aaa gaa aa Ala Asp Pro Glu Gin cag gac tta caa ggt Gin Asp Phe Gin Gly aaa aaa gag ata gaa Asn Pro Ala Leu Ala taa gaa gaa aat gta Tyr Ala Asp Thr Val acc act gga qtt act gca ggt acc gat atc acc act ggt ctg cag caa 403 Thr Thr Gly VIal Thr Ala Gly Thr Asp Ile Thr Thr Gly Leu Gin Gin 95 100 gtg gca gaa atg ctg agc taqttttgaq atgttgaaac tag 444 Val Ala Glu Met Leu Ser <210> 396 <211> 107 <212> PRT <213> Corynebacterium giutamicun <400> 396 Met Val Met Pro Giu Ser Ala Met Leu 1 5 Gly Gly Thr Pro Val Val Asp Ser Leu Ala Asp Pro Giu Gin Val Val Ala Met 40 Gin Asp Phe Gin Giy Lys Gly Arq Giu Asn Pro Ala Leu Ala Asn Val Pro Ala Tyr Ala Asp Thr Val Thr Thr Giy Val Thr Gly Leu Gin Gin Val Ala Giu Met 100 105 Thr 10 Gly Al a As n Ile Thr 90 Le u Ile Gly Ile Asn Asp Thr Glu Ile Ile Leu Ile Ile <210> 397 <211> 1479 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(1456) <223> RXA02261 <400> 397 gaaatctata gaacqatagg taaaaactgg actccgctcg acagcatcac ttagctgaaa cta gcc tgg att ctc qca gct ttt g Leu Ala Trp Ile Leu Ala Ala Phe A gga ttg tcc ctg ctc tac ggc ggc a Gly Leu Ser Leu Leu Tyr Gly Gly M actaggttta tctatagcgg aatagaaaat ggcctttaac atg gac ccc tca gat Met Asp Pro Ser Asp 1 cg ttg gta aqc ctg atg ttc ccc ia Leu Val Ser Leu Met Phe Pro 15 tg ctg qgt ggg caa cac gtt ctt et Leu Gly Giy Gin His Val Leu 30 115 163 211 aac acg ttc Asn Thr Phe atg atg gtt atg Met Met Val Met agc Ser tca ott gga ato Ser Leu Gly Ile agc ctt gtg Ser Leu Val 259 tao atc Tyr Ile att tat gga cac Ile Tyr Gly His ott gto tta gga Leu Val Leu Gly tcc atc ggt ggg Ser Ile Gly Gly tgg Trp gga att. ato gga Gly Ile Ile Giy 000 ott gaa tao Pro Leu Giu Tyr tto Phe ggo ttc ogo aao Gly Phe Arg Asn 307 355 403 atg gaa gat gao Met Giu Asp Asp aco gga gao oto Thr Gly Asp Leu tgg goc ggo ttc Trp Ala Gly Phe tao att. Tyr Ile 100 otg tto got Leu Phe Ala oqo atg ogo Arg Met Arq 120 ato toa cto gca Ile Ser Leu Ala ott. Leu 110 gtt toa tot ggt Val Ser Ser Gly goa gog ggg Ala Ala Gly 115 tgg tto ac Trp Phe Thr ttt gga gog tgg Phe Gly Ala Trp gtc tto ggt gto Val Phe Gly Val ttt qtg Phe Val 135 tao gcg oca otg goa cac tgg gtt tto Tyr Ala Pro Leu Ala His Trp Val Phe 140 ato gat gat cot Ile Asp Asp Pro gag Glu 150 too go tao gtg Ser Gly Tyr Val ggo tgg atg aaa Gly Trp Met Lys aat Asn 160 gtg ott gag tto Val Leu Glu Phe gao ttt got ggt Asp Phe Ala Gly gga Gly 170 acg goa gtg cac Thr Ala Val His aat gog ggt gog Asn Ala Gly Ala tot. gga Ser Gly 180 oto gog otg Leu Ala Leu oca oao aao Pro His Asn 200 gca Ala 185 ata qtg otg gga Ile Val Leu Gly cgo oao too atg Arg His Ser Met got gtg ogt Ala Val Arg 195 ato qtt gog Ile Val Ala ott ooa otg att Leu Pro Leu Ile ttg Le ~i 205 att, ggt goa gga Ile Gly Ala Gly ggo tgg Gly Trp 215 tto gga tto aat Phe Gly Phe Asn ggt aoo goa ggt Gly Thr Ala Gly goc aao tto oto Ala Asn Phe Leu 691 739 787 835 883 ago tao gtg gto Ser Tyr Val Val gt t Val1 235 aoo tot oto att Thr Ser Leu Ile got Al a 240 goa got ggc gga. Ala Ala Gly Gly atg ggo tto atg Met Gly Phe Met oto Leu 250 gtt gaa ogt gtg Val Glu Arg Val ago gga aaa 000 Ser Gly Lys Pro aot tto Thr Phe 260 ttt ggo tog Phe Gly Ser goa Al a 265 aoo ggo aoa ato Thr Gly Thr Ile goa Ala 270 ggo ott gtg got Gly Leu Val Ala ato aco cog Ile Thr Pro 275 gcc gcg gat Ala Ala Asp 280 gca gtg agc ecg Ala Val Ser Pro gga gca ttc gee Gly Ala Phe Ala gtc Val1 290 gga gcg etc Gly Ala Leu 979 ggc gca Gly Ala 295 gtt gtc tcc ttc Val Val Ser Phe gca att agc tgg Ala Ile Ser Trp aag Lys 305 aag gga cac ega Lys Gly His Arg gat gat tee tte Asp Asp Ser Phe ga t Asp 315 gtg tte gca gtc Val Phe Ala Val gga atg 9CC ggc Gly Met Ala Gly 1027 1075 1123 gca ggt gca ctg Ala Gly Ala Len ttt Phe 330 gtc atg etc ttt Val Met Len Phe gat cca eta gca Asp Pro Leu Ala cca qg Pro Ala 340 gga gtt tc Gly Val Ser qaa cca etg Giu Pro Leu 360 gte ttc ttc ggt Val Phe Phe Gly gaa etc tee ctg Glu Leu Ser Leu etg tgg agg Len Trp Arg 355 ggc gtg acc Gly Val Thr 1171 1219 gee ate atc gtg Ala Ile Ile Val ctt aca tac gca Leu Thr Tyr Ala tgg ttg Trp Leu 375 att gee acg ate Ile Ala Thr Ile ttg Le u 380 aae aag ttc atg Asn Lys Phe Met act Thr 385 etg ege ate ace Leu Arg Ile Thr gaa gee gaa tat Gin Ala Glu Tyr qgc att gao ege Gly Ile Asp Arg gaa cac gea gaa Glu His Ala Giu 1267 1315 1363 gee tac eac ete Ala Tyr His Leu aat Asn 410 tee aae gga att Ser Asn Giy Ile atg gea ace ege Met Ala Thr Arg ace aat Thr Asn 420 tte gga cot Phe Gly Pro ggc gte gat Gly Val Asp 440 ate ce gag gaa Ile Pro Gin Glu gtg ccc gac gee Val Pro Asp Ala gtg eag gtg Val Gin Val 435 aag eaa aaa ate Lys Gin Lys Ile gat-act ega aag Asp Thr Arg Lys gee tea aaa Ala Ser Lys 450 1411 1456 1479 tgaeegeaae etacaccact gaa <210> 398 <211> 452 <212> PRT <213> Corynebaeterium glutamieum <400> 398 Met Asp Pro Ser Asp Leu Ala Trp Ile Len 1 5 10 Ala Ala Phe Ala Leu Val Ser Leu Met Phe Pro Gly Len Ser Len 25 Gly Gln His Val Leu Asn Thr Phe Met 40 Leu Tyr Gly Gly Met Len Gly Ser Leu Gly Met Val Met Ser Ile As r Gly Ala Ser Val1 Al a 145 Val Al a Ser Gly Gly 225 Ala Gly Val1 Al a Lys 305 Gly Pro Ser Ile Ser Phe Gly Gly Le u 130 Ile Leu Gly Met Leu 210 Al a Ala Lys Ala Val1 290 Lys Met Le u Le u Le u Gly As n T yr 100 Al a Ph e Asp Phe Ser 180 Val1 Val Phe Gi y Thr 260 Thr Ala His Gi y Pro 340 Trp Val1 Gly Ile Ile Gly Thr Pro His 165 Gly Arg Al a Le u Met 245 Phe Pro Leu Arg Ile 325 Ala Arg Tyr Trp 70 Met Leu Arg Phe Glu 150 Asp Leu Pro Gly Ala 230 Met Phe Ala Gly Val 310 Ala Gly Glu Ile 55 Gly Glu Phe Met Val1 135 Ser Phe Al a His Trp 215 Ser Gly Gly Al a Al a 295 Asp Gly Val1 Pro Ile Ile Asp Ala Arg 120 T yr Gly Ala Leu Asn 200 Phe T yr Phe Se r Asp 280 Val Asp Ala Ser Leu 360 Tyr Ile Asp Ala 105 Phe Al a T yr Gly Al a 185 Le u Gly Val1 Met Al a 265 Ala Val1 Ser Leu Gi y 345 Al a Gly Gi y Gly 90 Ile Gi y Pro Val1 Gly 170 Ile Pro Phe Val Leu 250 T hr Val1 Ser Phe Phe 330 Val Ile His As n 75 Thr Se r Ala Le u Gly 155 Thr Val1 Leu Asn Val 235 Val1 Gi y Ser Phe Asp 315 Val1 Phe Ile Gly Pro Gly Le u Trp Ala 140 Gly Ala Leu Ile Gly 220 Thr Glu Thr Pro Trp 300 Val1 Met Phe Val1 Le u Le u Asp Al a Le u 125 His Trp Va 1 Gly Le u 205 Gly Se r Arg Ile Le u 285 Ala Phe Le u Gly Thr 365 Val1 Glu Leu Leu 110 Val1 Trp Met His Arg 190 Ile Thr Leu Val1 Ala 270 Gly Ile Al a Phe Gly 350 Leu Le u T yr Met Val1 Phe Val1 Lys Met 175 Arg Gly Al a Ile Phe 255 Gi y Al a Se r Val1 Gly 335 Glu Th r Gly Phe Trp Ser Gly Phe As n 160 Asn His Ala Gly Ala 240 Ser Leu Phe T rp His 320 Asp Leu Tyr Ala Phe Gly Val Thr Trp Leu Ile Ala Thr Ile 370 375 Thr Leu Arg Ile Thr Ser Glu Ala Glu Tyr Giu 385 390 395 Glu His Ala Glu Ser Ala Tyr His Leu Asn Ser 405 410 Ala Thr Arg Thr Asn Phe Gly Pro Giu Ile Pro 420 425 Asp Ala Val Gin Val Gly Val Asp Lys Gin Lys 435 440 Lys Ala Ser Lys 450 <210> 399 (211> 1111 <212> DNA <213> Corynebacterium glutamicum <220> <221> COS <222> (101)..(1111) <223> RXA02020 <400> 399 ttggtcaatc aagcqtgaat ccggcttcca tqagccagtt Leu 380 Gb y As n Giu Ile As n Ile Gly Giu Ala 445 Met Ala 400 Met Pro Arg gcccqcctca aagcttgacc cattttcata accagtgcca tgtgggttta cggttgatac atg gct aaa tct aat Met Ala Lys Ser Asn gaa Glu ctc Leu atc Ile 9C Al a cgt Arg cac His atg ctg Leu tcC Ser gca Al a gjt t Val1 gcc Ala gct Ala atq a cc TIhr att Ile 99 Gly ctt Leu gga Gly ttC Phe 9C gga Giy ggt Gly ccc Pro gtt Val t cg Ser 75 t cc Ser qaa cgg Arg gga Gly gtg Val 45 caa Gin tca Ser qgt Gly act a ccr Thr ct g Le u ctc Le u a tg Met cgt Arg tqq Trp ggC cac His ctc Le u gcg Ala gg C Gly gg C Gly 80 tac Tyr 1 ctc Le u ggC Gly tac Tyr gag Glu gag Giu tgg Trp atg gga Met Gly gtt ggt Val Gly gcc gga Ala Gly gct gcc Ala Ala ttc ggc Phe Gly ctg att Leu Ile 100 163 211 259 307 355 403 gct gct gcc atc atg ggt gca Met Val Met tgg ttc ggc Trp Phe Gly 120 Ala Glu Met Thr Al AaAale Ala Ala Ala Ile Met Gly Ala 115 gtg gte ttc Val Val Phe gte gaa ccg tgg Val Glu Pro Trp cet tcg ett gte Pro Ser Leu Val tgc Cys 130 tte gct Phe Ala 135 gtg gtg aac ctc Val Val Asn Leu gte Val1 140 gcg gtt ege ggt Ala Val Arg Gly ggt gaa tte gag Gly Giu Phe Giu tac Tyr 150 tgg ttc gca ttc Trp Phe Ala Phe aag gte geg gtg Lys Val Ala Val atc gct ttc etc Ile Ala Phe Leu atc Ile 165 att qgt att get Ile Gly Ile Ala ct t Leu 170 att ttc qqa tgg Ile Phe Gly Trp ctt Leu 175 ccc gga tcc ac Pro Gly Ser Thr ttt gtt Phe Val 180 gga aec tea Gly Thr Ser tct ggt gtt Ser Gly Val 200 ttc atc ggt gat Phe Ile Gly Asp gga ttc atg ccc Gly Phe Met Pro aat ggt att Asn Gly Ile 195 ttt ggt gge Phe Gly Gly get qet ggt ttg Ala Ala Gly Leu etc Leu 205 gCg gtg get ttt Ala Val Ala Phe gce Ala 210 att gaa Ile Glu 215 att gte ace att Ile Val Thr Ile gca Ala 220 get gca gag tee Ala Ala Glu Ser aag eca cgt gaa Lys Pro Arg Giu get Ala 230 att tee etg geg Ile Ser Leu Ala cgt gee gtg att Arg Ala Val Ile egt att tea gte Arg Ile Ser Val 787 835 883 tac ttg ggc tet Tyr Leu Gly Ser ttg gte ate act Leu Val Ile Thr etc atg cet tat Leu Met Pro Tyr ate aat ggt Ile Asn Giy geg atg gea Ala Met Ala 280 gee Al a 265 gac ace get geg Asp Thr Ala Ala ga a Glu 270 tee ccc ttc ace Ser Pro Phe Thr eaa ate etg Gln Ile Leu 275 geg ate ate Ala Ile Ile aae ate ect ggc Asn Ile Pro Gly gtt ggt ttc atg Val Gly Phe Met gtt eta Val Leu 295 gea ctg ctt tee Ala Leu Leu Ser tte aac gee caa Phe Asn Ala Gin ate Ile 305 tat gee act tet Tyr Ala Thr Ser 1027 1075 cgt Arg 310 ttg gta ttt tee Leu Val Phe Ser atg Met 315 geg aat ega caa Ala Asn Arg Gin gac Asp 320 get ceg ega gtt Ala Pro Arg Val tte Phe 325 agt aag etc age Ser Lys Leu Ser age eac gte ccc Ser His Val Pro ace aat geg Thr Asn Ala 335 1111 <210> 400 <211> 337 '<212> PRT <213> Corynebacterium glutamicum <400> 400 Met Ala Lys Ser Asn Giu Gly Leu Gly Thr Gly Leu Arg Thr Arg His 1 5 10 Leu Thr Met Met Gly Leu Gly Ser Ala Ile Gly Ala Gly Leu Phe Leu 25 Gly Thr Gly Val Gly Ile Arq Ala Ala Gly Pro Ala Val Leu Leu Ala 40 Tyr Ile Ile Ala Gly Ala Ile Val Val Leu Val Met Gin Met Leu Gly 55 Giu Met Ala Ala Ala Arg Pro Ala Ser Gly Ser Phe Ser Arg Tyr Gly 70 75 Giu Asp Ala Phe Gly His Trp Ala Gly Phe Ser Leu Gly Trp Leu Tyr 90 Trp Phe Met Leu Ile Met Val Met Gly Ala Giu Met Thr Gly Ala Ala 100 105 110 Ala Ile Met Gly Ala Trp Phe Gly Val Glu Pro Trp Ile Pro Ser Leu 115 120 125 Val Cys Val Val Phe Phe Ala Val Val Asn Leu Val Ala Val Arg Gly 130 135 140 Phe Gly Glu Phe Glu Tyr Trp Phe Ala Phe Ile Lys Val Ala Val Ile 145 150 155 160 Ile Ala Phe Leu Ile Ile Gly Ile Ala Leu Ile Phe Gly Trp Leu Pro 165 170 175 Gly Ser Thr Phe Val Gly Thr Ser Asn Phe Ile Gly Asp His Gly Phe 180 185 190 Met Pro Asn Gly Ile Ser Gly Val Ala Ala Gly Leu Leu Ala Val Ala 195 200 205 Phe Ala Phe Gly Gly Ile Glu Ile Val Thr Ile Ala Ala Ala Giu Ser 210 215 220 Asp Lys Pro Arg Glu Ala Ile Ser Leu Ala Val Arg Ala Val Ile Trp 225 230 235 240 Arg Ile Ser Val Phe Tyr Leu Gly Ser Val Leu Val Ile Thr Phe Leu 245 250 255 Met Pro Tyr Giu Ser Ile Asn Gly Ala Asp Thr Ala Ala Giu Ser Pro 260 265 270 Phe Thr Gin Ile Leu Ala Met Ala Asn Ile Pro Gly Thr Vai Gly Phe 275 280 285 Met Giu Ala Ile Ile Val Leu Ala Leu Leu Ser Ala Phe Asn Ala Gin 290 295 300 Ile Tyr Ala Thr Ser Arg Leu Val Phe Ser Met Ala Asn Arq Gin Asp 305 310 315 320 Ala Pro Arg Val Phe Ser Lys Leu Ser Thr Ser His Val Pro Thr Asn 325 330 335 Al a <210> 401 <211> 784 <212> DNA <213> Corynebacterium glutamicum <220> <221> COS <222> (101). .(784) <223> RXA00281 <400> 401 ggttgactct ttggctttga tgccagcatt cgccaaagcg tggccctctt taagaaagct actgaacaca acagagtagg tttatgcgac actggtgcgc atg atc aac gtt gaa Met Ile Asn Val Glu ggc Gly ttc Phe gcc Ala act Thr aa t As n cca Pro 9gg Gly act Thr ca a ctc Le u gaa Glu gga Gi y gca Al a ccc Pro aat Asn ctg Le u ggt Gi y cgt acc Th r gta Val1 aaa Lys 9gg Gly ctg Leu a qa Arg t cc Se r gt t Val1 120 cta caa Gin ccc Pro acc Th r gcc Al a aaa Lys gca Al a aaa Lys tca Se r ctt ggt Gly ata Ile atq Met atc Ile 60 gga Gly aac Asn gt c Val1 aag Lys g ca cag Gin gtc Val1 cqq Arg 45 gaa Gl u gca Al a cac His gat Asp acc Thr 125 gca cg c Arg 15 gga Gly atc Ile ca a Gin ctt Le u aag Lys qt t Val1 Gi y ctc gca Ala ttt Phe ctt Leu ccc Pro gat Asp 80 t gg T rp ctc Leu ttt Phe ggc 1 gtc Val1 ctc Leu ggc Gi y tac Tyr gcc Al a atc Ile acc Thr t ca Ser ga t gat Asp ggc Gly tta Le u cga Arg aaa Lys gcc Al a ctc Le u ct a Le u 130 ccg agc Ser ggc Gly cca Pro aaa Lys cac His aat Asn ctg Leu 9gc Gly tta Gin Arg Leu Gly Leu Ala Ala Ala Leu 135 140 att ctc gac gaa ccc gtc aac ggc ctt Ile Leu Asp Giu Pro Val Asn Gly Leu 150 155 gtg cgc acc ttg ttg caa aac atc gcc Val Arg Thr Leu Leu Gin Asn Ile Ala 170 gtg agt tcc cac ctq ctg tcc gag atg Val Ser Ser His Leu Leu Ser Giu Met 185 190 atc gtg att ggg cgt ggc aag ctq gtc Ile Val Ile Giy Arg Gly Lys Leu Val 200 205 ttt gtg cgc tcc cat tcc gct tcc aca Phe Vai Arg Ser His Ser Ala Ser Thr 215 220 <210> 402 <211> 228 <212> PRT <213> Corynebacterium giutamicum (400> 402 Met Ile Asn Vai Giu Gly Leu Thr Lys 1 5 Val Asp Asp Leu Ser Phe Giu Val Lys 25 Leu Gly Pro Asn Giy Ala Gly Lys Ser 40 Giy Leu Asp Asn Pro Thr Ala Giy His 55 Tyr Arg Ser Leu Lys Asn Pro Leu Thr 70 Ala Lys Ala Thr His Pro Asn Arg Thr Ile Ala Arq Ala Asn Gly Leu Ser Thr 100 105 Thr Leu Val Giy Leu Thr Gly Vai Gly 115 120 Ser Leu Gly Met Gly Gin Arg Leu Gly 130 135 Asp Pro Giu Tyr Leu Ile Leu Asp Giu 145 150 Giu Gly Ile His Trp Val Arg Thr Leu Leu Gly Asp 145 gac cca gaa Asp Pro Giu 160 aag cag ggc Lys Gin Giy 175 gcg caa act Ala Gin Thr gcc gat atg Ala Asp Met gtt gtg gtg Val Val Val 225 Pro ggc Gly aga Arg gcg Al a ccc Pro 210 Cgg Arg Giu att Ile acc Thr gaa Glu 195 atg Met gca Ala Tyr Leu cac tgg His Trp 165 gtg ctc Val Leu 180 cat ttg His Leu cat gag His Giu gca Ala Gin Tyr Gly Gin Val Arg Ala 10 Pro Giy Ile Val Thr Gly Phe Thr Thr Met Arg Leu Ile Leu Ala Thr Ile Glu Gly Gin Pro Lys Val Giy Ala Leu Leu Asp 75 Ala Giu Asn His Leu Lys Trp 90 Lys Arg Val Asp Giu Val Leu 110 Ser Lys Lys Thr Gly Gly Phe 125 Leu Ala Ala Ala Leu Leu Gly 140 Pro Val Asn Gly Leu Asp Pro 155 160 Leu Gin Asn Ile Ala Lys Gin Giy Arg Thr Val Leu Val Ser Ser His 180 185 Thr Ala Giu His Leu Ile Val Ile Gly 195 200 Leu Leu Ser Glu Met Aia Gin 190 Val Ala Asp Arg Giy Lys Met Pro Met His Giu Phe Val Arg Ser His Ser Ala 210 215 220 Ser Thr Val Val Val Arg Ala Ala 225 <210> 403 <211> 852 <212> DNA <213> Corynebacteriun glutamicun <220> <221> CDS <222> (852) <223> RXN00570 <400> 403 acg aga cct cgg ccc Thr Arg Pro Arg Pro 1 5 caa gaa att. ggc Gin Giu Ile Gly ggg ott gtc goa Gly Len Val Ala ctg att Leu Ile ttc tcc gca Phe Ser Ala gga aac ctt Gly Asn Leu gga ccc atc gca Gly Pro Ile Ala qtg Val1 atc ctg got got Ile Leu Ala Ala got gca gog Ala Ala Ala gqa gca ttt Giy Ala Phe tog cot qat caa Ser Pro Asp Gin aca Thr 40 tot toa tgg atc Ser Ser Trp Ile t to The tta gqo Leu Gly s0 aac gga otg oto Asn Gly Leu Leu otg tgg ott ace Leu Trp Leu Thr atq tao ogo ago Met Tyr Arg Ser cag goa tao tto Gin Ala Tyr Phe aog att 000 gga Thr Ile Pro Gly gto ato gtg ggc Val Ile Val Gly gao Asp toa Ott aco cao Ser Leu Thr His agt tto got gaa Ser Phe Ala Giu gt t Val1 ate ggo goa tao Ile Gly Ala Tyr ott gtt Leu Val aoc ggo gtt Thr Gly Val ato atg gog Ile Met Ala 115 gtg Val1 100 gtg ttt geg etc Val Phe Ala Leu gga Giy 105 tgg aoo ggt oto Trp Thr Gly Leu ate gga egg Ile Gly Arg 110 gtc goa ggo Val Ala Gly 336 384 gta otg oca eca Val Leu Pro Pro ate gtg atg goo Ile Val Met Ala att tto Ile Phe 130 ote ogo ttc gga oto gao oto ate gao Leu Arg Phe Gly Leu Asp Leu Ile Asp 135 gc Ala 140 ago gtg aco gao Ser Val Thr Asp ccg ctc att gca ctt ccc atg gtc ata gtt ttt gtg gca ttg agc atg 480 Pro Leu Ile Ala Leu Pro Met Val Ile Val Phe Val Ala Leu Ser Met 145 150 155 160 agt ccc cgc ttg gca agc ate gcc cca ccc gtt gca gta gcc gca gta 528 Ser Pro Arg Leu Ala Ser Ile Ala Pro Pro Val Ala Val Ala Ala Val 165 170 175 gtg gga acc atc gtt gcc atc gca tec ggc aaa cta gcg tcc gga att 576 Val Gly Thr Ile Val Ala Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile 180 185 190 cta gac aac gga att atc tcc cgc ccc gtc ttt acc gcc cca gaa ttt 624 Leu Asp Asn Gly Ile Ile Ser Arg Pro Val Phe Thr Ala Pro Glu Phe 195 200 205 tcc ttc gcc gcc atc atg gaa ctc gtt gtt ccc ttg gcg ate ace gta 672 Ser Phe Ala Ala Ile Met Glu Leu Val Val Pro Leu Ala Ile Thr Val 210 215 220 gtc att gtc caa aac ggc caa ggc gtc gca gtg ctt aaa gca gca ggt 720 Val Ile Val Gin Asn Gly Gin Gly Val Ala Val Leu Lys Ala Ala Gly 225 230 235 240 cac cgc ccc gga gta aac ctt gcc gcc gcg gcc tec gga ctg tgg tec 768 His Arg Pro Gly Val Asn Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser 245 250 255 cta ccc atg gcg ttg ate ggc aac ate ace ace tgc etc ace ggc ccc 816 Leu Pro Met Ala Leu Ile Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro 260 265 270 ace aac gcg ctg ate gtc gcc gga gca aaa tca cac 852 Thr Asn Ala Leu Ile Val Ala Gly Ala Lys Ser His 275 280 <210> 404 <211> 284 <212> PRT <213> Corynebacterium glutamicum <400> 404 Thr Arg Pro Arg Pro Gin Glu Ile Gly Asn Gly Leu Val Ala Leu Ile 1 5 10 Phe Ser Ala Ser Gly Pro Ile Ala Val Ile Leu Ala Ala Ala Ala Ala 25 Gly Asn Leu Ser Pro Asp Gin Thr Ser Ser Trp Ile Phe Gly Ala Phe 40 Leu Gly Asn Gly Leu Leu Thr Leu Trp Leu Thr Tyr Met Tyr Arg Ser 55 Pro Gin Ala Tyr Phe Trp Thr Ile Pro Gly Thr Val Ile Val Gly Asp 70 75 Ser Leu Thr His Leu Ser Phe Ala Glu Val Ile Gly Ala Tyr Leu Val 90, Thr Gly Val Val Val Phe Ala Leu Gly Trp Thr Gly Leu Ile Gly Arg 100 105 110 Ilie Met Ala Val Leu Pro Pro Thr Ile Val Met Ala Met Val Ala Gly 115 120 125 Ile Phe Leu Arg Phe Gly Leu Asp Leu Ile Asp Ala Ser Val Thr Asp 130 135 140 Pro Leu Ile Ala Leu Pro Met Val Ile Val Phe Val Ala Leu Ser Met 145 150 155 160 Ser Pro Arg Leu Ala Ser Ile Ala Pro Pro Val Ala Val Ala Ala Val 165 170 175 Val Gly T1hr Ile Val Ala Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile 180 185 190 Leu Asp Asn Gly Ile Ile Ser Arq Pro Val Phe Thr Ala Pro Glu Phe 195 200 205 Ser Phe Ala Ala Ile Met Giu Leu Val Val Pro Leu Ala Ile Thr Val 210 215 220 Val Ile Val Gin Asn Gly Gin Gly Val Ala Val Leu Lys Ala Ala Gly 225 230 235 240 His Arg Pro Gly Val Asn Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser 245 250 255 Leu Pro Met Ala Leu Ile Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro 260 265 270 Thr Asn Ala Leu Ile Val Ala Gly Ala Lys Ser His 275 280 <210> 405 <211> 498 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (498) <223> FRXA00570 <400> 405 cca acc atc gtg atg gcc atq gtc gca ggc att ttc ctc cgc ttc gga 48 Pro Thr Ile Val Met Ala Met Val Ala Gly Ile Phe Leu Arg Phe Gly 1 5 10 ctc gac ctc atc gac gce agc gtg aec gac ccg ctc att gca ctt ccc 96 Leu Asp Leu Ile Asp Ala Ser Val Thr Asp Pro Leu Ile Ala Leu Pro 25 atg gtc ata gtt ttt gtg gca ttg agc atg agt ccc cgc ttg gca age 144 Met Val Ile Val Phe Vai Ala Leu Ser Met Ser Pro Arg Leu Ala Ser 40 ate Ile atc Ile tee Ser ga a Glu caa Gin ctt Le u 9gC Giy 145 gCC Ala 9CC Ala gea Ala ege Arg etc Le u gge Gly gc Al a 130 aae As n ggja Gly eca Pro tce Se r cee Pro gt t ValI gte ValI 115 gee Al a ate Ile gca Al a ccc Pro gge Gly gte Vai gtt Val1 100 gea Al a 9c9 Al a ace Thr aaa Lys gtt gea Val Ala aaa cta Lys Leu 70 ttt ace Phe Thr eec ttg Pro Leu gtg ett Val Leu gee tee Ala Ser ace tgc Thr Cys 150 tea eac Ser His 165 gta Val1 9eg Ala gee eca Ala Pro gcg ate Ala Ile aaa qca Lys Ala 120 gqa ctg Gly Leo 135 etc ace Leu Thr gca gta Ala Val gga att Gly Ile gaa ttt Glu Phe 90 ace gta Thr Val 105 gea ggt Ala Gly tgg tee Trp Ser ggc c Gly Pro gtg Val1 eta Leu 75 tee Ser gt c ValI ea e His eta Leu ace T hr 155 Ile Pro Ser Val1 Leu Ser Val1 His aae gga Asn Gly gee gee Ala Ala gte eaa Val Gin 110 eec gga Pro Gly 125 atg geg Met Ala geg ctq Ala Leu att ate Ile Ile ate atg Ile Met aac ggc Asn Gly gta aac Val Asn ttg ate Leu Ile ate gte Ile Val 160 ace ate gtt gee Thr Ile Val Ala 192 240 288 336 384 432 480 '<210> 406 <211> 166 <212> PRT <213> Corynebacterium glutamicum <400> 406 Pro Thr Ile Val Met Ala Met Val Ala 1 Leu Asp Leu Ile Asp Ala Ser Val Thr 25 Met Val Ile Val Phe Val Ala Leu Ser Ile Ala Pro Pro Vai Ala Val Ala Ala Ile Ala Ser Gly Lys Leu Ala Ser Gly 70 Ser Arg Pro Val Phe Thr Ala Pro Glu Glu Leo Val Val Pro Leo Ala Ile Thr 100 105 Gin Gly Val Ala Val Leo Lys Ala Ala Arq Ala Leo Ile Gly Al a Gin 110 Gly LeU Ala Ala Ala Ala Ser Gly Leu Trp Ser Leu Pro 130 135 140 Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro Thr Asn 145 150 155 Met Ala Leu Ile Ala Leu Ile Ala Gly Ala Lys Ser His 165 <c210> 407 <211> 1280 <212> DNA <213> Corynebacterium glutamicun <220> <221> CDS <222> (1257) <223> RXN00571 <400> 407 aca ctt gtt cca cag Thr Leu Val Pro Gin 1 5 gtt tao gaa ata Val Tyr Glu Ile gtq Val 10 atc tac ggc got Ile Tyr Gly Ala gtg ctq Val Leu tea qct gta Ser Ala Val gte goc ggc Val Ala Gly gaa gat cca ace Glu Asp Pro Thr atc ggt gcg ctc Ile Gly Ala Leu ayc cea gca Ser Pro Ala atg atc gqt Met Ile Gly acc ott ggt tcc Thr Leu Gly Ser goc atg ate ggc Ala Met Ile Gly gtg Val got cta Ala Leu tot gca ggt gc Ser Ala Gly Ala ggt gao ogo ott Gly Asp Arg Leu cgt ogo aaa gtt Arg Arg Lys Val atg Met etc ace goa ate Leu Thr Ala Ile gte Val 70 tgg tte tot gtg Trp Phe Ser Val ggc Gly atg gog otg ace Met Ala Leu Thr 1 92 240 288 tte gog too tog Phe Ala Ser Ser geg etg tte ggt Ala Leu Phe Gly ttg ego tto etc Leu Arg Phe Leu ace gga Thr Gly Ott ggc gtg Leu Gly Val tte get oca Phe Ala Pro 115 Gi y 100 atg ate gtt gca Met Ile Val Ala ace Thr 105 ggc gge gca ate Gly Gly Ala Ile ate geg gag Ile Ala Glu 110 gtg tao tee Val Tyr Ser gog aat agg ego Ala Asn Arg Arg ttg ttc aac gca Leu Phe Asn Ala ate Ile 125 ggt gtc Gly Val 130 eca goc ggt ggc Pro Ala Gly Gly etg get tot ate Leu Ala Ser Ile gca ctg etc ttt Ala Leu Leu Phe gaa gat gte ate ggc tgg ego gga ete tto etc ate ggt gga tee eca Glu Asp Val Ile Gly Trp Arg Gly Leu Phe Leu Ile Gly Giy Ser Pro 150 155 cta ctg ttc Ctc Leu Leu Phe Leu cca ctt gca tac Pro Leu Ala Tyr ttc Phe 170 ttc ctc cca gag Phe Leu Pro Glu tcc ccg Ser Pro 175 cgc tgg ctc Arg Trp Leu gca cgc tat Ala Arg Tyr 195 tcc cqc ggc cgt Ser Arg Gly Arg gcg gac gcc aaa Ala Asp Ala Lys gcc ctc tgc Ala Leu Cys 190 aag zag zag Lys Gln Gln 576 624 ggg ctg ccg acg Gly Leu Pro Thr qaa ttt gtc Glu Phe Val gaa aca Glu Thr 210 aag ggc acc gga Lys Gly Thr Gly ttc Phe 215 gct gqa att ttc Ala Gly Ile Phe tca aag tac ctc Ser Lys Tyr Leu atg Met 225 ggc acc att ctc Gly Thr Ile Leu ggc gca atg agc Gly Ala Met Ser atc ggg ctg att Ile Gly Leu Leu acc tac ggc ctg Thr Tyr Gly Leu aac Asn 245 acc tgg ttg cca Thr Trp Leu Pro atc atg gaa tc Ile Met Glu Ser aac ggc Asn Gly 255 gca acc tca Ala Thr Ser gaa gtg ttc Ala Val Phe 275 gat tcc ctg tac Asp Ser Leu Tyr ctg ctg tta ctc Leu Leu Phe Leu aac gqc ggc Asn Gly Gly 270 cgc atc ggc Arg Ile Gly ggt ggc ata atc Gly Gly Leu Ile tca tgg ttc gct Ser Trp Phe Ala gag aag Ala Lys 290 aca gtg atc acc Thr Val Ile Thr aca ttc gct ata Thr Phe Ala Leu gao Ala 300 gcg atc tgc ctc Ala Ile Cys Leu gga Gl y 305 gtc ctg cca Val Leu Pro atc Ile 310 tcc tac tgg aca Ser Ser Trp Pro atg tac acc ga Met Tyr Thr Ala 912 960 1008 gaa ttc gca ggc Ala Phe Ala Gly ggc gto atg ggc Gly Val Leu Gly zag gtt ctc aco Gln Val Leu Thr tac ggc Tyr Gly 335 ctg acc tag Leu Thr Ser tgg tgt a Trp Cys Ala 355 ttc ttc gga acc Phe Phe Gly Thr tgc cgc gca gag Cys Arg Ala Ala gga gtt gca Gly Val Ala 350 cca gaa atc Pro Ala Ile 1056 1104 qga ttc ggc cga Gly Phe Gly Arq at a Leu 360 ggc gqa ato gta Gly Gly Ile Val ggt ggc Gly Gly 370 atg ato ato ggc Leu Ile Ile Gly gga ttc gga ca Gly Phe Gly Pro tac gca ttc ctc Ser Ala Phe Leu 1152 1200 ttc gca gaa gct Phe Ala Ala Ala gcc Al a 390 gca atc ggc gag Ala Ile Gly Ala gt a Val1 395 tgc aac ttg atg Cys Thr Leu Leu CCg cgc tcc cca gca gaa gta gag gtc aag gtc gcq cag gaa cca ctt Pro Arg Ser Pro Ala Glu Val Glu Val Lys Val Ala Gin Glu Pro Leu 405 410 415 gca cgt gtc taaccccaat taattcgaaa caa Ala Arg Val <210> 408 <211> 419 <212> PRT <213> Corynebacteriun glutamicum <400> 408 1248 1280 Thr Leu Val 1 Ser Val1 Ala Met Phe Leu Phe Gly Glu 145 Le u Arq Al a Glu Ala Al a Leu Leu Al a Gly Ala Val1 130 Asp Leu T rp Arg Thr 210 Pro Gin Val 5 His Giu Asp Thr Leu Gly Ala Gly Ala Ala Ile Val 70 Ser Ile Ala Gly Met Ile 100 Ala Asn Arg Ala Gly Gly Ile Gly Trp 150 Leu Leu Pro 165 Thr Ser Arg 180 Gly Leu Pro Gly Thr Gly Glu Thr Tyr Gly Phe Phe Ala Asn 120 Leu Gly Ala Arg Giu 200 Ala Val1 Ile Met Arq Val1 ?he Gly Phe Ser Phe Phe 170 Ala Phe Ile Ile Gly Ile Leu Gly 75 Le u Gly Asn Ile Leu 155 Phe Asp Val1 Phe Gly Leu Val1 Arg Ala Phe Ile Ile 125 Ala Gly Pro Lys Glu 205 Ser Al a Ser Met Arg Le u Leu Ile 110 Val Le u Gly Giu Ala 190 Lys Lys Leu Al a Gi y Val1 Ala Gly Glu Ser Phe Pro 160 Pro Cys Gin Le u Ser 240 Met Gly Thr Ile Leu 225 Ile Giy Ala Met Ser Phe Ile Gly Leu Leu Thr Tyr Gly Leu Asn Thr Trp Leu Pro Lys Ile Met Glu Ser Asn Gly 245 250 255 Ala Ala Al a Gly 305 Al a Leu Trp Gly Ile 385 Pro Ala Thr Val1 Lys 290 Val1 Phe Thr Cys Gly 370 Phe Arg Arg Ser Phe 275 T hr Le u Ala Ser Ala 355 Leu Ala Ser Val1 His 260 Gly Val1 Pro Gly Asn 340 Gly Ile Ala Pro Asp Gly Ile Asn Val1 325 Phe Phe Ile Ala Ala 405 Ser Leu Thr Ile 310 Gly Phe Gly Gly Al a 390 Giu Leu Ile Ser 295 Se r Val1 Gly Arq Ala 375 Al a Val Tyr Al a 280 Thr Ser Le u Thr Le u 360 Giy Ile Giu Ser 265 Se r Phe Trp Sly Si u 345 Gly Ph e Gly Val1 gtc Val1 gct klia 25 at 9 le t :tc Le u T rp Al a Pro Thr 330 Cys Gi y Gi y Al a Lys 410 gCC Ala 10 ct a Leu ctc Le u 9c9 Leu Phe Phe Ala Leu Ala 300 Met Met 315 Gin Val Arg Ala Ile Val Pro Ser 380 Val Cys 395 Val Ala *qgc acc Gly Thr tct qca Ser Ala acc gca Thr Ala tcc tcg Leu Asp 285 Ala Tyr Leu Ala Gly 365 Ser Thr Gin ctt Leu ggt Gly atc Ile att As n 270 Arg Ile Thr Th r Gi y 350 Pro Al a Leu Giu 9qt Gly gcc Ala gtc Val1 gcg Gly Ile Cys Al a T yr 335 Val1 Ala Phe Leu Pro 415 t CC Ser gtt Val1 t gg Trp Ctg Gi y Gly Le u Ile 320 Gi y Al a Ile Leu Ile 400 Le u tac Tyr gg t Gly ttc Phe t tc <210> 409 <211> 1208 <212> DNA <213> Corynebacterium giutarnicum <220> <221> CDS <222> (1185) <223> FRXA00571 <400> 409 cag atc ggt gcq ctc agc cca gca Gin Ile Giy Ala Leu Ser Pro Ala 1 5 gcc atg atc qgc qtg atg atc ggt Ala Met Ile Gly Vai Met Ile Sly gac cgc ctt qgt cgt cgc aaa gtt Asp Arg Leu Giy Arg Arg Lys Val 40 tct gtg ggc atg gcq ctg aco qcg Ser Val Gly Met Ala Leu Thr 55 Ala Phe Ala Ser Ser Ile Ala Leu Phe ttc ttg egc ttc Phe Leu Arg Phe ctc Leu acc gga ctt ggc Thr Gly Leu Gly ggc atg atc gtt Gly Met Ile Val ace ggc ggc gca Thr Gly Gly Ala ate Ile atc gcg gag ttc Ile Ala Giu Phe cca geg aat agg Pro Ala Asn Arg cge aae Arg Asn ttg tte aac Leu Phe Asn get tet ate Ala Ser Ile 115 atc gtg tac tee Ile Val Tyr Ser ggt Gi y 105 gte eca gee ggt Val Pro Ala Gly ggc gtg etg Gly Val Leu 110 tgg ege gga Trp Arg Gly ett gea etg cte Leu Ala Leu Leu gaa gat gte ate Glu Asp. Val Ile gge Gly 125 etc ttc Leu Phe 130 etc ate ggt gga Leu Ile Gly Gly eca eta etg tte Pro Leu Leu Phe etc Leu 140 etg eca ett gea Leu Pro Leu Ala tac Tyr 145 ttc ttc etc cca Phe Phe Leu Pro gag Giu 150 tee ceg ege tgg Ser Pro Arg Trp, ace tee ege ggc Thr Ser Arg Gly 432 480 528 get geg gac gee Ala Ala Asp Ala gee etc tgc gca Ala Leu Cys Ala egc Arg 170 tat ggg etg ceg Tyr Gly Leu Pro aeg gag Thr Giu 175 gaa ttt gte Giu Phe Val gga att tte Gly Ile Phe 195 gte Val1 180 gaa aag eag eag Giu Lys Gin Gin aea aag ggc ace Thr Lys Gly Thr gga ttc get Gly Phe Ala 190 ate gge gca Ile Gly Ala 576 624 tee tee .aag tae Ser Ser Lys Tyr atg gge ace att Met Giy Thr Ile atg age Met Ser 210 ttc ate ggg ctg Phe Ile Gly Leu et t Le u 215 tcg ace tac ggc Ser Thr Tyr Gly ctg Le u 220 aae ace tgg ttg Asn Thr Trp Leu aag ate atg ga Lys Ile Met Giu aac gge ges ace Asn Gly Ala Thr cat gat tee etg His Asp Ser Leu 672 720 768 tee ctg ctg tte Ser Leu Leu Phe etc Leu 245 sac ggc gge ges Asn Gly Gly Ala gtg Val1 250 ttc ggt gge etc Phe Gly Gly Leu ate gea Ile Ala 255 tee tgg ttc Ser Trp Phe ttc get etc Phe Ala Leu 275 gac ege ate gge Asp Arg Ile Gly aag ace gtg ate Lys Thr Vai Ile ace tee ace Thr Ser Thr 270 ate tee tee Ile Ser Ser 816 864 gee geg ate tgc Ala Ala Ile Cys etc Leu 280 gga gte etg eca Gly Val Len Pro sac As n 285 tgg eca atg atg tac ace gea ate gea tte gca ggc gte ggc gte ctg Trp Pro Met Met Tyr Thr Ala Ile Ala Phe Ala Gly Val Gly Val Len 290 295 ggc acc cag gtt ctc acc tac ggc Gly Thr Gin Val Leu Thr Tyr Gly 305 310 gaa tgc cgc gca gcg gga gtt gca I Glu Cys Arg Ala Ala Gly Val Ala 325 ggc gqa atc gtc gga cca gca atc Gly Gly Ile Vai Gly Pro Ala Ile 340 ttc gga cca agc tcc gca ttc ctc Phe Gly Pro Ser Ser Ala Phe Leu 355 360 ggc gcg gtc tgc acc ttg ctg atc Gly Ala Val Cys Thr Leu Leu Ile 1 370 375 gtc aag gtc gcg caq gaa cca ctt Val Lys Val Ala Gin Giu Pro Leu 385 390 caa <210> 410 <211> 395 <212> PRT (213> Corynebacterium giutamicum acc Thr tgt Cys 330 ggc Gly ttc Phe cqc Arg cgt Arg 300 aac ttc ttc gga acc 960 Asn Phe Phe Gly Thr 320 gga ttc gqc cga ctc 1008 Gly Phe Gly Arg Leu 335 atc atc ggc gca gga 1056 Ile Ile Gly Ala Gly 350 gca gct gcc gca atc 1104 Ala Ala Ala Ala Ile 365 cca gca gaa gta gag 1152 Pro Ala Giu Val Glu 380 taaccccaat taattcgaaa 1205 1208 <400> 410 Gin Ile Gly Ala Leu Ser Pro Ala Val Ala Gly Thr Leu Gly Ser Tyr 1 Al a Asp Ser Gly Thr Le u Ala Leu Ilie Leu Gi y Leu Gi y Asn Ile 115 Le u 5 Val Arg Ala Phe Ile Ile Ala Gly Met Arq Le u Le u 70 Ile ValI Leu Gly Gly Val1 40 Ala Gly Giu Ser Phe 120 Pro Ala Met The Leu Phe Gi y 105 Glu Leu Ser Thr Ser Val1 75 Pro Pro Val Phe Gly Ile Ile Met As n Gly Gly 125 Leu Ala Val1 Al a Ile Arg Gly 110 Trp Pro Val1 Trp Leu ValI Arg Val1 Arg Leu Gly Phe Phe Ala As n Leu Gi y Ala Tyr Phe Phe Leu Pro Glu Ser Pro Arg Trp Len Thir Ser Arg Giy Arg 145 150 155 160 Ala Ala Asp Ala Lys Ala Len Cys Ala Arg Tyr Gly Len Pro Thr Glu 165 170 175 Glu Phe Val Val Gin Lys Gin Gin Glu Thr Lys Gly Thr Gly Phe Ala 180 185 190 Gly Ile Phe Ser Ser Lys Tyr Leu Met Gly Thr Ile Leu Ile Gly Ala 195 200 205 Met Ser Phe Ile Gly Len Leu Ser Thr Tyr Gly Leu Asn Thr Trp Leu 210 215 220 Pro Lys Ile Met Gin Ser Asn Gly Ala Thr Ser His Asp Ser Leu Tyr 225 230 235 240 Ser Leu Leu Phe Len Asn Gly Gly Ala Val Phe Gly Gly Le Ile Ala 245 250 255 Ser Trp Phe Ala Asp Arg Ile Gly Ala Lys Thr Vai Ile Thr Ser Thr 260 265 2'70 Phe Ala Leu Ala Ala Ile Cys Leu Gly Val Len Pro Asn Ile Ser Ser 275 280 285 Trp Pro Met Met Tyr Thr Ala Ile Ala Phe Ala Gly Val Gly Val Leu 290 295 300 Gly Thr Gin Val Len Thr Tyr Gly Leu Thr Ser Asn Phe Phe Gly Thr 305 310 315 320 Gin Cys Arg Ala Ala Gly Val Ala Trp Cys Ala Gly Phe Gly Arg Len 325 330 335 Gly Gly Ile Val Gly Pro Ala Ile Gly Giy Leu Ile Ile Gly Ala Giy 340 345 350 Phe Gly Pro Ser Ser Ala Phe Leu Ile Phe Ala Ala Ala Ala Ala Ile 355 360 365 Gly Ala Val Cys Thr Len Leu Ile Pro Arg Ser Pro Ala Giu Val Giu 370 375 380 Val Lys Val Ala Gin Gin Pro Len Ala Arg Val 385 390 395 <210> 411 <211> 689 <212> DNA <213> Corynebacterinm gintamicnm <220> <221> CDS <222> (666) <z223> RXA00962 <400> 411 aag gcc atc aag gcq gat cac gac Lys Ala Ile Lys Ala Asp His Asp aga qaa ggc cac Arg Gin Gly His gat gag Asp Glu cca gca ggt Pro Ala Gly att tgg ttc Ile Trp Phe aag gat ctg ctt Lys Asp Leu Len gt c Val1 gat cgc tac cgc Asp Arg Tyr Arg tgg atc tcc Trp Ile Ser tgg tac gga Trp Tyr Gly gcg ctc gcc aca Ala Leu Ala Thr gtc acc ctg ctc Val Thr Len Leu gcg Ala ctg ggc Leu Gly aca tgg ttg cct Thr Trp Len Pro cgc Arg ctc atg gaa act Leu Met Gin Thr ggt tat gag ttc Gly Tyr Gin Phe ggc Gly cat gca ttg atg His Ala Leu Met acc ctq gct ctg Thr Leu Ala Leu ctc qqt gca gtg Leu Gly Ala Val atc Ile gga tcc gtg gtt Gly Ser Val Val gcg tgg gcc gyc Ala Trp Ala Gly cgc ttc ggg cca Arg Phe Gly Pro atc cgt Ile Arg tcc ggt gtc Ser Gly Val ctc act tac Len Thr Tyr 115 atc Ile 100 gct gca ggt atc Ala Ala Gly Ile gcc Ala 105 ggt att gca ctg Gly Ile Ala Len ctc ctg ctg Len Len Leu 110 att ttg gct Ile Len Ala ccg cct gtc acc Pro Pro Val Thr gtt tat qtc att Val Tyr Val Ile ctc Len 125 ggc gtg Giy Val 130 ggc acc cac ggc Giy Thr His Giy act Thr 135 cag atc ctc atc Gin Ile Leu Ile gca qct gtc gcc Ala Ala Val Ala aac Asn 145 ttc tac cca agc Phe Tyr Pro Ser aac: Asn 150 ctg cgt ggc aca Leu Arg Gly Thr ctg qyc tgg gcg Leu Gly Trp Ala 432 480 528 qgt gta ggt cgt Giy Val Gly Arg ggt gct gtt gtg Gly Ala Val Val ccg cag ctc gct Pro Gin Leu Ala ggc ctg Gly Len 175 ctg ctg gca Leu Leu Ala aac ttg ggc gtg Asn Len Gly Val tcc aac ttc atc Ser Asn Phe Ile atg ttc ggc Met Phe Gly 190 ctg cgc ctg Leu Arg Leu 576 acc get qcq ctg ctc tct gcg Thr Ala Ala Len Leu Ser Ala ctg Len 200 qct ctc agc gtg Ala Len Ser Val t tg Len 205 cag aaa Gin Lys 210 acc tac agc qtc Thr Tyr Ser Val acc Thr 215 cac aaa gtc gaa His Lys Val Gin atc caa ggc Ile Gin Gly 220 taaccccctt tttcaactca cag <210> 412 <z211> 222 <212> PRT (213> Corynebacterium glutamicun <400> 412 Asp Pro Ile Le u Gly GlI y Ser Len Gly As n 145 Gly Leu Thr Gin Lys Ala Trp Gly His Se r Gly Th r Val1 130 Phe Val1 Len Al a Lys 210 Ala Gi y Phe Thr Al a ValI Val Tyr 115 Gly Tyr Gly Ala Al a 195 Thr Ile Phe Ala Trp Len Val1 Ile 100 Pro Thr Pro Arg Trp 180 Len Tyr Ala Asp His Asp Asp Al a Pro Phe Al a Al a Val1 Gly A~nn 150 Gi y Len Ser Val1 Len Phe 40 Len Len Al a Ile Al a 120 Gin Arg ValI Val1 Leu 200 His Val1 25 Val Met Ala Gly Ala 105 Val1 Ile Gly Val1 Asn 185 Ala Lys Ile Asp Thr Gin Len Asp Gly Tyr Len Thr Ala 170 Ser Len Val1 Gin Tyr Len Al a Len Phe Al a ile Ile 140 Leu Gin Phe Val1 Ile 220 Gi y Arg Ala Gly Gly Gly Len Len 125 Ala Cly Len Ile Len 205 Gin His T rp, Trp, T yr Ala Pro Len 110 Ile Al a T rp Ala Met 190 Len Gly Asp Ile Tyr Gin Val Ile Len Len ValI Al a Gly 175 Phe Arg <210> 413 <211> 484 <212> DNA <213> Corynebacterium qiutamicum <220> <221> CDS <222> (101)..(484) <223> RXA02811 <400> 413 cataatcact ctttccagat agcggaatcc ctttgattgt aacttggctc acctcgatta tgtgtttatg acatcacacq caccagaatc gggaggactt gtg aca gag tca act 115 Val Thr Glu Ser Thr 1 ctc gga gca tcg aat agc tcc caa aca att gaa. aat aaa ggc ctc acc 163 Leu Gly Ala Ser Asn Ser Ser Gin Thr Ile Giu Asn Lys Gly Leu Thr 15 atc ttg ggc atc agc ggc cga cgc ttg gct qcg gtg ctc att ggc tgg 211 Ile Len Gly Ilie Ser Gly Arg Arg Leu Ala Ala Val Le Ile Gly Trp 30 ttt ttt gtc att ttc gac ggc tac gac ctc att gtg tac ggc acc gtc 259 Phe Phe Val Ilie Phe Asp Gly Tyr Asp Leu Ilie Val Tyr Gly Thr Val 45 caa tcq gcc ctg gct aag gag tgg aac tta agc tct gca acg ctq ggc 307 Gin Ser Ala Leu Ala Lys Gin Trp Asn Leu Ser Ser Ala Thr Leu Gly 60 acc atc ggc tcc acc gcg ttc ttt ggc atg gcg atc ggc gct gtg ttc 355 Thr Ile Gly Ser Thr Ala Phe Phe Gly Met Ala Ile Gly Ala Val Phe 75 80 att qqt cga ctg tca gac cgc gtg ggc cga aaa qca. gcg gtg att gga 403 Ile Giy Arg Leu Ser Asp Arg Val Gly Arq Lys Ala Ala Vai Ile Gly 95 100 tcc gtg ctg att ctc tct gtc ttc acc atg ctg tgt gca ttt gct cca 451 Ser Val Leu Ile Len Ser Val Phe Thr Met Leu Cys Ala Phe Ala Pro 105 110 115 aac cca tgg gtg ttc ggc gct ttc cgt ttc atc 484 Asn Pro Trp Val Phe Gly Ala Phe Arg Phe Ile 120 125 <210> 414 <211> 128 <212> PRT <213> Corynebacterium glutamicun (400> 414 Val Thr Gin Ser Thr Leu Gly Ala Ser Asn Ser Ser Gin Thr Ile Giu 1 5 10 Asn Lys Gly Len Thr Ile Leu Gly Ile Ser Gly Arg Arg Len Ala Ala 25 Val Le Ile Giy Trp Phe Phe Val Ilie Phe Asp Gly Tyr Asp Le Ile 40 Val Tyr Gly Thr Val Gin Ser Ala Leu Ala Lys Glu Trp Asn Len Ser 55 Ser Ala Thr Leu Gly Thr Ile Gly Ser Thr Ala Phe Phe Gly Met Ala 70 75 Ile Gly Ala Val Phe Ile Gly Arg Leu Ser Asp Arq Val Gly Arg Lys 90 Ala Ala Val Ile Giy Ser Val Leu Ilie Len Ser Val Phe Thr Met Len Cys Ala Phe Ala Pro Asn Pro Trp Val Phe Gly Ala Phe Arg Phe Ile 115 120 125 <210> 415 <211> 1197 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1197) <223> RXA02115 <400> 415 acc cgc gca acc aaa Thr Arg Ala Thr Lys 1 5 agt gtc gga aca Ser Val Gly Thr ctc gca ctc ctg Leu Ala Leu Leu tgg ttc Trp Phe gca att gtc Ala Ile Val ccg tcc atg Pro Ser Met ctc Leu gac ggc ttt gao Asp Gly Phe Asp gtC gtc ctg ggt Val Val Leu Gly gca aca atc Ala Thr Ile gga cag gcc Gly Gin Ala ctg gag gat ccc Leu Giu Asp Pro tgq gat ctc act Trp Asp Leu Thr aca cag Thr Gin att tcc acc atc Ile Ser Thr Ile ctc gtc ggc atg Leu Val Gly Met acc Th r att gqc gca ctg Ile Gly Ala Leu acc Thr aic ggt ttc tta Ile Gly Phe Leu a cg Thr gac cgt ctg ggt Asp Arg Leu Gly cgc cgt gtc atg Arg Arg Vai Met 192 240 288 ttc tct gtq gca Phe Ser Val Ala ttt tot gta ttc Phe Ser Val Phe ctc ctg ctg gca Leu Leu Leu Ala ttc acc Phe Thr acc aac gtc Thr Asn Val ctt ggt gga Leu Giy Giy 115 cag Gin 100 ctc ttc agc ctg Leu Phe Ser Leu tgg Trp 105 cgt ttc ctc gca Arg Phe Leu Ala ggt gtt gqc Gly Vai Gly 110 gag ttc cgc Giu Phe Arg 336 384 gca ctc ccc acc Ala Leu Pro Thr att gcc atg gtg Ile Ala Met Val ccc ggc Pro Gly 130 acc aaa gcg qgc Thr Lys Ala Gly gca tcc acc ac Ala Ser Thr Thr ttg Leu 140 atg acc ggc tac Met Thr Gly Tyr 432 480 ca c His 145 gtc ggc gca gta Val Giy Ala Val gca Ala 150 acc gcc ttc ctt Thr Ala Phe Leu 9gC Gi y 155 ctc ttc ctt atc Leu Phe Leu Ile ggc ttt ggt tgg cac tcc atg ttc atc gca ggt gcc qta cca gga ctg Giy Phe Gly TrpGlAl Va PrSeMt ele Ser Met Phe Ile Gly Ala Val Pro Gly Leu 175 atc ctg cta Ile Leu Leu otc aaa atc Leu Lys Ile 195 Ctg ctg tac ttc Leu Leu Tyr Phe ttc The 185 ctt cca gaa too Leu Pro Glu Ser cog cag tac Pro Gin Tyr 190 gca gca. tct Ala Ala Ser too ggo aag ttg Ser Giy Lys Leu gag gcg cag gca Glu Ala Gin Ala gt t Val1 205 tat gga Tyr Gly 210 Ott too otg gat Leu Ser Leu Asp gat Asp 215 gat dtt gat cgo Asp Leu Asp Arg cac gaa gaa gaa His Glu Giu Glu ctc Leu 225 ggo gag tcc tcc Gly Glu Ser Ser ctt too tcc otg Leu Ser Ser Leu aag ccc tcq tto Lys Pro Ser Phe cqc Arg 240 cgc aao acc ctg Arg Asn Thr Leu att tgg ggo aco Ile Trp Gly Thr ttc atg gga otc Phe Met Giy Leu ctc ctg Leu Leu 255 gtc tac ggc Vai Tyr Gly tao gac atg Tyr Asp Met 275 ot g Leu 260 aac aca tgg ctg Asn Thr Trp Leu oca Pro 265 oaa ato atg cgc Gin Ile Met Arg caa gca gac Gin Ala Asp 270 aac ato ggc Asn Ile Gly ggt aac tog ott Giy Asn Ser Leu gga Gly 280 ttc oto atg gtg Phe Leu Met Val ctc Le u 285 goa gtq Ala Val 290 ato ggo ott tat Ile Gly Leu Tyr qoa ggg oga att Ala Gly Arg Ile gat aag aao too Asp Lys Asn Ser oot Pro 305 ogo aaa aoa gca Arg Lys Thr Ala gta tgg tto gtg Val Trp Phe Val tot goa ttt too Ser Ala Phe Ser 912 960 1008 gog ttg ott got Ala Leu Leu Ala ogg atg ooa otg Arg Met Pro Leu ggt otg tat ggo Gly Leu Tyr Gly ato gtg Ile Val 335 otg otc aco Leu Leu Thr tto gtt qgt Phe Val Gly 355 ato ttt gtg ttc Ile Phe Val Phe ago Ser 345 too oaq gta Ser Gin Val oto ato tao gc Leu Ile Tyr Ala .350 1056 1104 gag aat oac Oct Glu Asn His Pro aag atg cgo gca Lys Met Arg Ala ac Thr 365 gcc atg gga. Ala Met Gly tto tc Phe Ser 370 goa gga att ggt Ala Gly Ile Gly cgc Arg 375 oto ggo goo ato Leu Gly Ala Ile tot S er 380 ggo oog ttg ott Gly Pro Leu Leu 1152 ggt Giy 385 ggt ctq ctt gtc Gly Leu Leu Val goc aao Ott got Ala Asn Leu Ala tao Tyr 395 ooa tgg ggo tto Pro Trp Gly Phe 1197 <210> 416 <211> 399 <212> PRT <213> Corynebacterium glutamicum <400> 416 Thr Arg Ala Thr Lys Ser Val Gly Thr Val Leu Ala Leu Leu Trp Phe 1 5 10 Ala Ile Val Leu Asp Gly Phe Asp Leu Val Val Leu Gly Ala Thr Ile 25 Pro Ser Met Leu Glu Asp Pro Ala Trp Asp Leu Thr Ala Gly Gin Ala 40 Thr Gin Ile Ser Thr Ile Gly Leu Val Gly Met Thr Ile Gly Ala Leu 55 Thr Ile Gly Phe Leu Thr Asp Arg Leu Gly Arg Arg Arg Val Met Leu 70 75 Phe Ser Val Ala Val Phe Ser Val Phe Thr Leu Leu Leu Ala Phe Thr 90 Thr Asn Val Gin Leu Phe Ser Leu Trp Arg Phe Leu Ala Gly Val Gly 100 105 110 Leu Gly Gly Ala.Leu Pro Thr Ala Ile Ala Met Val Thr Glu Phe Arg 115 120 125 Pro Gly Thr Lys Ala Gly Ser Ala Ser Thr Thr Leu Met Thr Gly Tyr 130 135 140 His Val Gly Ala Val Ala Thr Ala Phe Leu Gly Leu Phe Leu Ile Asp 145 150 155 160 Gly Phe Gly Trp His Ser Met Phe Ile Ala Gly Ala Val Pro Gly Leu 165 170 175 Ile Leu Leu Pro Leu Leu Tyr Phe Phe Leu Pro Glu Ser Pro Gin Tyr 180 185 190 Leu Lys Ile Ser Gly Lys Leu Asp Glu Ala Gin Ala Val Ala Ala Ser 195 200 205 Tyr Gly Leu Ser Leu Asp Asp Asp Leu Asp Arg Glu His Glu Glu Glu 210 215 220 Leu Gly Glu Ser Ser Ser Leu Ser Ser Leu Phe Lys Pro Ser Phe Arg 225 230 235 240 Arg Asn Thr Leu Ala Ile Trp Gly Thr Ser Phe Met Gly Leu Leu Leu 245 250 255 Val Tyr Gly Leu Asn Thr Trp Leu Pro Gin Ile Met Arg Gin Ala Asp 260 265 270 Tyr Asp Met Gly Asn Ser Leu Gly Phe Leu Met Val Leu Asn Ile Gly 275 280 285 Ala Val Ile Gly Leu Tyr Ile Ala Gly Arg Ile Ala Asp Lys Asn Ser 290 295 300 Arg Lys Thr Ala Va Tr PeVaLu 310 Val Trp Phe Val Phe 315 Ser Ala Phe Ser Ala Leu Leu Ala Arg Met Pro Leu Gly Leu Tyr Gly Ile Val 335 Leu Leu Thr Phe Val Gly 355 Ile Phe Val Phe Ser Ser Gin Val Leu 345 Ile Tyr Ala 350 Ala Met Gly Glu Asn His Pro Lys Met Arg Ala Thr 365 Phe Ser 370 Ala Gly Ile Gly Leu Leu Val Ser 390 Leu Gly Ala Ile Ser Gly Pro Leu Leu 380 Pro Trp Gly Phe Gly Ala Asn Leu Ala <210> 417 <211> 1288 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1288) <223> RXN00590 <400> 417 tctaaactca ctctcaactc accaagattg ttcaacaatc tgcgattggt gtgcaatcta cccaatoat tttgaaagcc oocaogaaag gaqgoggaca atg goc gac aac aaa Met Ala Asp Asn Lys aat gcc gat gac Asn Ala Asp Asp ago Ser cag cta gtc tca gco ago act gga aco Gin Leu Val Ser Ala Ser Thr Gly Thr 15 cot ggg Pro Gly oct ggc gac Pro Gly Asp gta acc gc Val Thr Ala qca aaa goc aat Ala Lys Ala Asn 9gg Al a cca tcc oto aag Pro Ser Leu Lys caa got gca Gin Ala Ala tto oto atg Phe Leu Met tot ggc cga ago Ser Gly Arg Ser ctg atg ggt gcc Leu Met Gly Ala a to Ile gca act Ala Thr tot gcc ato ggo Ser Ala Ile Gly ggg tto otc acc Gly Phe Leu Thr aoc got gto ttc Thr Ala Val Phe aoo Thr aac oag cto ggo Asn Gin Leu Gly gca Al a got ttc goa ttt Ala Phe Ala Phe ato otg gtg tog Ile Leu Val Ser oto att gao ato Leu Ile Asp Ile gog Ala gtg oag otg aat gtg tgg ogo ato ato Val Gin Leu Asn Val Trp Arg Ile Ile 95 ggo gto Gly Val 100 tct gaa atg Ser Glu Met ggt tgg gtg Gly Trp Val 120 090 Arg 105 gco caa gaa ctc Ala Gin Glu Leu aac aog gtt atc Asn Thr Val Ile cca gqt ttt Pro Gly Phe 115 otg gcc gta ctg Leu Ala Val Leu gtc tgt att ggc ggc gta gta ttc aac Val Gys Ile Gly Gly Val Val Phe Asn 125 130 ato ggc Ile Gly 135 aac atc gcc ggt Asn Ile Ala Giy ggc ott gqg ott Gly Leu Gly Leu aac gcg ctg ctt ggc Asn Ala Leu Leu Gly 145 gcc atc gcg att gcg Ala Ile Ala Ile Ala t gg Trp 150 gac gtc aaa gtt Asp Val Lys Val gg t Gi y 155 ggc gtg atc acc Gly Val Ile Thr 547 595 643 ato ttc ttg ttc Ile Phe Leu Phe aaq Lys 170 cga ctt ggt gct Arg Leu Gly Ala got Ala 175 ctg gac aaa ttc Leu Asp Lys Phe ctc gtg Leu Val 180 gtc otc ggc Val Leu Gly toc caa cot Ser Gin Pro 200 gtc gtg atg atc ctg ctc Val Val Met Ile Leu Leu 185 190 acc gtc tac gtg Thr Val Tyr Val gct ttc gtc Ala Phe Val 195 Ott cct gac Leu Pro Asp coa gtt ggo tog Pro Val Gly Ser ctg aag aat gca Leu Lys Asn Ala gta Val1 210 acc atc Thr Ile 215 gac tgg ctt gto Asp Trp Leu Val ato Ile 220 acc aca ctt gtg Thr Thr Leu Val ggt Gly 225 gga acc gtc ggt Gly Thr Val Gly gga Gly 230 tac ato act tac Tyr Ile Thr Tyr ggc gca cac cqc Gly Ala His Arg ctg gac tcc gga Leu Asp Ser Gly aco ggc coo aac Thr Gly Pro Asn aac Asn 250 gtc aaa got gtt Val Lys Ala Val tcc Ser 255 aat tcc tct atc Asn Ser Ser Ile acc qg Thr Gly 260 atc ctg atc Ile Leu Ile ggt gtt gtc Gly Val Val 280 gqc ctc atq cqo Gly Leu Met Arq qtg otc ttc cto Val Leu Phe Leu gcg gtt ctc Ala Val Leu 275 aac cca gcc Asn Pro Ala gca ggt ggc gtc Ala Gly Gly Val cta tcc acc acg Leu Ser Thr Thr ggc Gly 290 gcg gaa Ala Glu 295 gca ttc cag cac Ala Phe Gin His got Ala 300 gca gqo gat ato Ala Gly Asp Ile qga Gly 305 cta ogc atc ttc Leu Arg Ile Phe 990 Gly 310 goc gtg ctg tgg Ala Val Leu Trp gog too att tcc Ala Ser Ile Ser gtc ato gg gc Val Ile Gly Ala 1027 1075 1123 1171 tao acc tot gca Tyr Thr Ser Ala acc Th r 330 tto ctq gtg gaa Phe Leu Val Giu aac Asn 335 aag oca gag aag Lys Pro Glu Lys aag cgt Lys Arg 340 ctg caa aao tgg gtg aoc atc atc ttc atc ctg att tct tgc too gtg Leu Gin Asn Trp Val Thr Ile Ile 345 ttc atc atg ctc ggc acg gca cca Phe Ile Met Leu Gly Thr Ala Pro 360 365 gca ttc aac gqt ttq gtc ctc ccc Ala Phe Asn Giy Leu Val Leu Pro 375 380 gta gcq atc ttc cgc caa aaa Val Ala Ile Phe Arg Gin Lys 390 395 <210> 418 <211> 396 (212> PRT <213> Corynebacterium giutamicum ?he Ile Leu Ile Ser Cys Ser Val 350 355 aca atc ctc ttg gtc ttc gcc gga kila Ile Leu Leu Val Phe Ala Giy 370 Ita qqc ttt acc ctg atq atc tac /al Gly Phe Thr Leu Met Ile Tyr 385 1219 1267 1288 <400> 418 Met Ala Asp Asn Lys Asn Ala Asp Asp 1 Thr Leu Aila Gin Ile Arg Val Gly Asn 145 Ala Asp Gly Lys Ile Thr Leu Ile Ile Val1 130 Ala Ile Lys Thr Gin Phe Ala Vali Ile Pro 115 Val1. Leu Ala Phe Pro Ala Leu Val1 Ser Giy 100 Gly Phe Leu Ile Leu 180 Pro Val1 Ala Th r 70 Leu Ser Gly Ile Trp 150 Ile Val1 Giy Thr Th r Asn Ile Glu Trp Gly 135 Asp Ph e Le u Asp Ala Ser Gin Asp Met Val1 120 Asn ValI Leu Gly Ile Ser Ala Leu Ile Arg 105 Leu Ile Lys Phe Val1 185 Ser 10 Al a Gi y Ile Gly Ala Al a Ala Al a Val1 Lys 170 Val Gin Lys Arg Gly Ala Val1 Gin Val1 Gly Gly 155 Arg Met Ala Pro Met Leu Phe Val1 As n Ile Gly Thr Ala 175 Th r Tyr Val Ala Phe Val Ser Gin Pro Pro Val Gly Ser Ala Leu Lys Asn 195 200 205 Ala Val Leu Pro Asp Thr Ile Asp Trp Leu Val Ile Thr Thr Leu Val 210 215 220 Gly Gly Thr Val Gly Gly Tyr Ile Thr Tyr Ala Gly Ala His Arg Met 225 230 235 240 Leu Asp Ser Gly Arg Thr Gly Pro Asn Asn Val Lys Ala Val Ser Asn 245 250 255 Ser Ser Ile Thr Gly Ile Leu Ile Thr Gly Leu Met Arg Val Val Leu 260 265 270 Phe Leu Ala Val Leu Gly Val Val Ala Giy Gly Val Thr Leu Ser Thr 275 280 285 Thr Gly Asn Pro Ala Ala Glu Ala Phe Gln His Ala Ala Gly Asp Ile 290 295 300 Gly Leu Arg Ile Phe Gly Ala Val Leu Trp Ala Ala Ser Ile Ser Ser 305 310 315 320 Val Ile Gly Ala Ser Tyr Thr Ser Ala Thr Phe Leu Val Glu Asn Lys 325 330 335 Pro Glu Lys Lys Arq Leu Gin Asn Trp Val Thr Ile Ile Phe Ile Leu 340 345 350 Ile Ser Cys Ser Val Phe Ile Met Leu Gly Thr Ala Pro Ala Ile Leu 355 360 365 Leu Val Phe Ala Gly Ala Phe Asn Gly Leu Val Leu Pro Val Gly Phe 370 375 380 Thr Leu Met Ile Tyr Val Ala Ile Phe Arg Gin Lys 385 390 395 <210> 419 <211> 487 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(487) <223> FRXA00590 <400> 419 tacgctggcq cacaccgcat gctggactcc qgacqaaccq gccccaacac qtcaaagctg tttccaattc tctatcaccg qcatcctqat cactggcctc atg cgc gtg gtg ctc 115 Met Arg Val Val Leu 1 ttc ctc gcg gtt ctc ggt gtt gtc gca ggt ggc gtc aco cta tcc acc 163 Phe Leu Ala Vai Leu Gly Val Val Ala Gly Gly Val Thr Leu Ser Thr 15 acg gyc aac cca gcc gcg gaa gca ttc cag cac gct gca qgc gat atc 211 Thr Gly Asn Pro Ala Ala Giu Ala Phe Gin His Ala Ala Gly Asp Ile 30 gga cta cgc atc ttc qgc gcc gtg ctg tgg gca gcg tcc att tcc tca 259 Gly Leu Arg Ile Phe Gly Ala Val Leu Trp Ala Ala Ser Ile Ser Ser 45 gtc atc ggc gcc agc tac acc tct gca acc ttc ctg gtg gaa aac aag 307 Val Ile Gly Ala Ser Tyr Thr Ser Ala Thr Phe Leu Val Glu Asn Lys 60 cca gag aaq aag cgt ctg caa aac tgg gtg acc atc atc ttc atc ctg 355 Pro Glu Lys Lys Arg Leu Gin Asn Trp Val Thr Ile Ile Phe Ile Leu 75 80 att tct tgc tcc gtg ttc atc atg ctc ggc acg gca cca gca atc ctc 403 Ile Ser Cys Ser Val Phe Ile Met Leu Gly Thr Ala Pro Ala Ile Leu 95 100 ttg gtc ttc gcc gga gca ttc aac qgt ttq gtc ctc ccc gta ggc ttt 451 Leu Val Phe Ala Giy Ala Phe Asn Gly Leu Val Leu Pro Val Giy Phe 105 110 115 acc ctg atg atc tac gta gcg atc ttc cgc caa aaa 487 Thr Leu Met Ile Tyr Vai Aia Ile Phe Arg Gin Lys 120 125 <210> 420 <211> 129 <212> PRT <213> Corynebacterlum glutamicum <400> 420 Met Arg Val Val Leu Phe Leu Ala Val Leu Gly Val Val Ala Gly Gly 1 5 10 Val Thr Leu Ser Thr Thr Gly Asn Pro Ala Ala Glu Ala Phe Gin His 25 Ala Ala Gly Asp Ile Gly Leu Arg Ile Phe Gly Ala Val Leu Trp Ala 40 Ala Ser Ile Ser Ser Val Ile Giy Ala Ser Tyr Thr Ser Ala Thr Phe 55 Leu Val Glu Asn Lys Pro Giu Lys Lys Arg Leu Gin Asn Trp Val Thr 70 75 Ile Ilie Phe Ilie Leu Ile Ser Cys Ser Val Phe Ile Met Leu Gly Thr 90 Ala Pro Ala Ilie Leu Leu Val Phe Ala Gly Ala Phe Asn Gly Leu Val 100 105 110 Leu Pro Val Gly Phe Thr Leu Met Ile Tyr Val Ala Ile Phe Arg Gin 115 120 125 Lys <210> 421 <211> <212> <213> <220> <221> <222> <223> 490 DNA Corynebacterium glutamicum CDS (101)..(490) FRXA0 1538 (400> 421 tctaaactca ctctcaactc accaagattg ttcaacaatc ccccaatcat tttgaaagcc cccacgaaag gagcgcgaca tgcgattggt gtgcaatcta atg gcc gac aac aaa 11, Met Ala Asp Asn Lys aat gcc gat gac Asn Ala Asp Asp agc Ser cag cta gte tea gcc agc act gga acc Gin Leu Val Ser Ala Ser Thr Gly Thr 15 cct ggg Pro Gly cct ggc gac Pro Gly Asp gta ace gee Val Thr Ala gca aaa gcc aat Ala Lys Ala Asn eca tee etc aag Pro Ser Leu Lys caa get gea Gin Ala Ala ttc etc atg Phe Leu Met tet ggc cga age Ser Gly Arg Ser ctg atg ggt gee Leu Met Gly Ala ate Ile gea act Ala Thr tet gec ate ggc Ser Ala Ile Gly gqg tte etc ace Gly Phe Leu Thr ace get gte ttc Thr Ala Val Phe aac eag etc gge Asn Gin Leu Gly get tte gca ttt Ala Phe Ala Phe ate etg gtg teg Ile Leu Val Ser etc att gac ate .Leu Ile Asp Ile 9gg Ala gtg cag ctg aat Val Gin Leu Asn gtg Vali 95 tgg ege ate ate Trp Arg Ile Ile ggc gte Gly Val 100 tet gaa atg Ser Giu Met ggt tgg gtg Gly Trp Val 120 gee caa gaa etc Ala Gin Glu Leu gge Gi y 110 aac aeg gtt ate Asn Thr Val Ile eca ggt ttt Pro Gly Phe 115 etg gee gta etg Leu Ala Val Leu tgt att gge gge Cys Ile Gly Gly gta Val1 130 <210> 422 <211> 130 <212> PRT <213> Corynebacterium glutamicum <400> 422 Met Ala Asp Asn Lys Asn Ala Asp Asp Ser Gin Leu Val Ser Ala Ser 1 5 10 Thr Gly Thr Pro Gly Pro Gly Asp Ile Ala Lys Ala Asn Ala Pro Ser 25 Leu Ala Gin Ile Arg Val1 Gly Lys Ile Thr Leu Ile Ile Val1 130 Gin Phe Ala Val1 Ile Pro 115 Ala Leu Val1 Ser Gly 100 Gly Val1 Al a Th r 70 Leu Ser Gly Gi y Ile Gi y Al a Ala Al a Arg Gly Ala 75 Val1 Gin Val1 Ser Pro Al a Gin Glu Le u Le u Ph e Al a Asn Gly 110 Cys Met Leu Phe Val1 Asn Ile Gi y Thr Ala T rp Thr Gi y <210> 423 <211> 1401 <212> DNA <213> Coryriebacterium giutamicum <220> <221> CDS <222> (101)..(1378) <223> RXA01727 <400> 423 agcttttggt ggtttcacca cctgcgctcg tcttaatttt tgaggagggg ctgcgccgta tcgccaqcgt gttgtaaata gcgtgttcca gaqagaccct gtc Val1 aac Asn cta Leu ct g Leu gc t Ala tat Tyr ct g Leu ct C Leu cca Pro 9c9 Al a tct Ser ttg Leu act Thr ttc Phe atc Ile atc Ile gg c Gi y atc Ile t ct Ser ccg Pro tta Leu 9c9 Ala ggt Gly gg C Gi y ttg Leu ccg Pro gga Gly gtg Val aag Lys 75 g cg Ala ttt Phe gga Gly 30 gca Ala tcg Ser ggC Gly 9c9 Al a atg Met t cg Ser agt Ser gaa Giu gtg Val1 80 ccg Pro a tg Met 1 ttc Phe gca Ala gtt Val1 aa t As n ttt Phe agq Arg ag t Ser ttc Phe gga Gly Ctg Le u gtc Val1 cct Pro act Thr aaa Lys gga Gly acc Thr ctc Leu aag Lys att Ile gqg Gly aag Lys gct Ala aac Asn ccg Pro gac Asp gct Ala 9c9 Ala tct Ser gga Gly tat Tyr gt g Val1 at g Met gcc Ala gtg Val1 ago tat tcg Ser Tyr Ser ttt aao ttt Phe Asn Phe 120 gcg gtt ggo gto Ala Val Gly Val aat gcg ott, tat Asn Ala Leu Tyr tcg ggc ttg Ser Gly Leu 115 tgg aat ccg Trp Asn Pro qtg ttt ttt gcg Val Phe Phe Ala gca otg gog ttg Ala Leu Ala Leu aat ggc Asn Gly 135 att gca gao aag Ile Ala Asp Lys ttg Leu 140 ggt aag tgg ctc Gly Lys Trp Leu acg Thr 145 cca gcg ttg ctc Pro Ala Leu Leu ttg att gtg gtg Leu Ile Val Val gtg gtg ttg tcg Val Val Leu Ser gta Val1 160 qoc aag ttg gat Ala Lys Leu Asp acg cca ggt gag Thr Pro Gly Glu ooa Pro 170 agt agt gog tat Ser Ser Ala Tyr oag oag oot 909 Gin Gin Pro Ala ggg gog Gly Ala 180 ggt ttg ott. Gly Leu Leu ttt ggo atc Phe Gly Ile 200 gag Glu 185 ggo tao atg aog Gly Tyr Met Thr gat 909 att. got Asp Ala Ile Ala gog ttg 909 Ala Leu Ala 195 gtt aao aag Val Asn Lys gtg gtg att tot Val Val Ile Ser gcg Al a 205 tto aag tac oaa Phe Lys Tyr Gin aag Lys 210 gto 090 Val Arg 215 aog gca aot gtc Thr Ala Thr Val tcg 909 ttc att Ser Ala Phe Ile gga att ttg ttg Gly Ile Leu Leu 909 Al a 230 otg gtt tat ott Leu Val Tyr Leu ttg 990 toa ato Leu Gly Ser Ile ggt Gly 240 oaa. gta gta aac Gin Val Val Asn 99 t Gly 245 gag tto got gat Glu Phe Ala Asp 990 Gly 250 aoo goa att ttg Thr Ala Ile Leu aac As n 255 tao got goa otg Tyr Ala Ala Leu too aog Ser Thr 260 atg ggt cag Met Gly Gin tgt atg aco Cys Met Thr 280 got Ala 265 ggt 090 ato atg Gly Arg Ile Met gtg got att ttg Val Ala Ile Leu ato ott goa Ile Leu Ala 275 gag ttt ttc Glu Phe Phe aoo gca gtt ggt Thr Ala Val Gly atc agt gog aog Ile Ser Ala Thr aat tog Asn Ser 295 otg otg oca ggt Leu Leu Pro Gly 9tc Val1 300 aag tao oao gto Lys Tyr His Val t 99 Trp 305 goo act gtt tto Ala Thr Val Phe 909 Al a 310 ctg att too ttt Leu Ile Ser Phe gtt 900 acc atg Val Ala Thr Met ggt Gly 320 ttg gat acg gtg Leu Asp Thr Val 1027 1075 1123 900 gtt gog got Ala Val Ala Ala ooa Pro 330 gtg att agt ttc Val Ile Ser Phe tao oca tog gc Tyr Pro Ser Ala atc aco Ile Thr 340 ttg gtg ttc ttg tcg ctc atc gag ccc ctg ctg ttc cgt ctc aag tgg 1171 Leu Val Phe Leu Ser Leu Ile Glu Pro Leu Leu Phe Arg Leu Lys Trp 345 350 355 acc tac cta ttc gqc att. tgg act gca gtt. qtq tgg gcq ctg ttc atg 1219 Thr Tyr Leu Phe Gly Ile Trp Thr Ala Val Val Trp Ala Leu Phe Met 360 365 370 tct. atc cct gcg ctg aat cca. ttc atc gaa. tgg gcg ccq ctg cac agc 1267 Ser Ile Pro Ala Leu Asn Pro Phe Ile Glu Trp Ala Pro Leu His Ser 375 380 385 atg tct ttg ggt tgg qtt gtc cca gtt ctc gtg gcc tct gcc atc ggt 1315 Met Ser Leu Gly Trp Val Val Pro Val Leu Val Ala Ser Ala Ile Gly 390 395 400 405 ttg gct. att. gat tgg aac aag aaa gqt gcc cag tct gtt gca aag aag 1363 Leu Ala Ile Asp Trp Asn Lys Lys Gly Ala Gin Ser Val Ala Lys Lys 410 415 420 qaa tcc att tcc gtc taatcgctaa ttgcgaggag tct 1401 Glu Ser Ile Ser Val 425 <210> 424 <211> 426 <212> PRT <213> Corynebacterium glutamicum <400> 424 Met Ser Lys Lys Ser Val Leu Ile Thr Ser Leu Met Leu Phe Ser Met 1 5 10 Phe Phe Gly Ala Gly Asn Leu Ile Phe Pro Pro Met Leu. Gly Leu Ser 25 Ala Gly Thr Asn Tyr Leu Pro Ala Ile Leu Gly Phe Leu Ala Thr Ser 40 Val Leu Leu Pro Val Leu Ala Ile Ile Ala Val Val Leu Ser Gly Glu 55 Asn Val Lys Asp Met Ala Ser Arg Gly Gly Lys Ile Phe Gly Leu Val 70 75 Phe Pro Ile Ala Ala Tyr Leu Ser Ile Gly Ala Phe Tyr Ala Leu Pro 90 Arq Thr Gly Ala Val Ser Tyr Ser Thr Ala Val Gly Val Asp Asn Ala 100 105 110 Leu Tyr Ser Gly Leu Phe Asn Phe Val Phe Phe Ala Val Ala Leu Ala 115 120 125 Leu Ser Trp Asn Pro Asn Gly Ile Ala Asp Lys Leu Gly Lys Trp Leu 130 135 140 Thr Pro Ala Leu Leu Thr Leu Ile Val Val Leu Val Val Leu Ser Val 145 150 155 160 Ala Lys Leu Asp Gly Thr Pro Gly Glu Pro Ser Ser Ala Tyr Ala Gin 165 170 175 Gin Ile Gin Ala 225 Gin Ala Ile Thr Trp 305 Leu Pro Phe T rp Al a 385 Ala Ser Pro Al a Lys 210 Gl y Val1 Al a Leu Ser 290 Ala Asp Ser Arg Ala 370 Pro Ser Val1 Ala Ala 195 Val1 Ile Val1 Leu Ilie 275 Glu Thr Thr Ala Leu 355 Leu Leu Ala Ala Gly 180 Leu As n Leu Asn Ser 260 Le u Phe Val1 Val Ile 340 Lys Phe His Ilie Lys 420 Ala Ala Lys Leu Gly 245 Thr Ala Phe Phe Leu 325 Thr Trp Met Ser Gly 405 Lys Gly Phe Val Al a 230 Glu Met Cys As n Ala 310 Al a Le u Thr Se r Met 390 be u Glu be u Gi y Arg 215 Le u Phe Gl y Met Ser 295 be u Val ValI T yr Ile 375 Ser Ala Ser be u Ile 200 Thr Val1 Al a Gin Thr 280 Leu Ile Ala Phe Leu 360 Pro Leu Ile Ile Giu 185 Val1 Ala Tyr Asp Ala 265 Thr Leu Ser Al a Leu 345 Phe Ala Gly Asp Ser 425 Gi y Val1 Th r be u Gl y 250 Gly Ala Pro Phe Pro 330 Ser Gly Le u Trp T rp 410 Val Tyr Ile Val1 Gi y 235 Th r Arg Val1 Gl y Gly 315 Val be u Ile Asn Val 395 As n Met Ser Val1 220 Le u Ala Ile Gly Val1 300 Val1 Ile Ile Trp Pro 380 Val Lys Thr Ala 205 Ser Gly Ile Met beu 285 Lys Al a Ser Glu Thr 365 Phe Pro Lys Met 190 Phe Al a Ser Le u Phe 270 Ile Tyr Thr Phe Pro 350 Al a Ile ValI Gl y Asp Lys Phe Ile As n 255 Val Se r His Met Ile 335 Le u Val1 Glu beu Ala 415 Ala T yr Ile Gly 240 T yr Ala Ala Val1 Gly 320 Tyr beu Val1 Trp ValI 400 Gin <210> 425 <211> 1461 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1438) <223> RXA00623 <400> 425 tttaagcttc gtcggcaacg atcacaccac gttaaatttc gttttttggc gaatccccaa aaaggtcgaa gaggaagttc gaccatcaat gacggtggcc atg Met 1 gat tca aac aca Asp Ser Asn Thr gaa tct tca agt Giu Ser Ser Ser gag gtc aaa aac Giu Val Lys Asn cac att aaa gtt His Ile Lys Val caa aag Gin Lys ccg ccg aag Pro Pro Lys gca ttg att Ala Leu Ile aag Lys gac cgc act cac Asp Arg Thr His tgg T rp 30 ctc tac att gcg Leu Tyr Ile Ala qtc att atc Val Ile Ile gag ttg ggc Giu Leu Gly ggc ggt att acc Gly Gly Ile Thr ggc ctg att tca Gly Leu Ile Ser ccg Pro aaa gaa Lys Giu ttc aag att ttq Phe Lys Ile Leu ggc ci y 60 acc atg ttt gtg Thr Met Phe Val t cc Se r ttg atc aag atg Leu Ile Lys Met atc gct cca gtt Ile Ala Pro Val ttc tgc acc atc Phe Cys Thr Ile atc gga atc ggt Ile Gly Ile Giy gtc aag gca gcg Val Lys Ala Ala gca Ala aca gtc gga cgc Thr Val Gly Arq gct Ala 95 ggt ggc atc gcc Gly Gly Ile Ala ctt gcg Leu Ala 100 tac ttc atc Tyr Phe Ile atg tcc aca ttc Met Ser Thr Phe ctc gca gtt ggc Leu Ala Val Gly ctg cta gtc. Leu Leu Val 115 gtt gat gaa Val Asp Giu ggt aac ttc atc cag cca ggt agc Gly Asn Phe Ile Gin Pro Gly Ser 120 125 gga ctg aac atc Gly Leu Asn Ile gaa tct Giu Ser 135 ttc atc PheIle 150 tca ttc gca tcc Ser Phe Ala Ser aca Thr 140 gag agc agc cct Giu Ser Ser Pro gaa Giu 145 gga ctc ttg gga Gly Leu Leu Gly 499 547 595 643 cac tcg atc His Ser Ile cct gaa acg ttc Pro Glu Thr Phe tct gca ttt act Ser Ala Phe Thr ggt tcg gtg ctg Giy Ser Val Leu cag Gin 170 gta ctg ttc atc Val Leu Phe Ile gcc Ala 175 atc ctc gtq ggc Ile Leu Val Gly ttt gca Phe Ala 180 gct cag tcg Ala Gin Ser cat ctg cag His Leu Gin 200 ggt gaa aag gqa Gly Giu Lys Gly cag Gin 190 ccc atc ctt gat Pro Ile Leu Asp ttc gta tcc Phe Val Ser 195 ctg tgg ctc Leu Trp Leu 691 739 aag ctc atc ttc Lys Leu Ile Phe att ttg aac tgg Ile Leu Asn Trp att Ile 210 900 cca Ala Pro 215 gtc ggt gca ttc Val Gly Ala Phe ggt Gly 220 gca atg gcc ggc Ala Met Ala Gly gtc ValI 225 gtt ggc gaa aoa Val Gly Glu Thr ttt gat goc gtt Phe Asp Ala Val gt t Val1 235 cag ctc gqt att Gin Leu Gly Ile atc ctc gco ttt Ile Leu Ala Phe gto acc tgo gtg Val Thr Cys Val ttc atc ttt ggc Phe Ile Phe Gly ctg ggo gcc gta Leu Gly Ala Val otg aag Leu Lys 260 qtg tto acc Val Phe Thr gaa ttc ctg Glu Phe Leu 280 990 Gly 265 gtg aat atc ttc Val Asn Ile Phe aag Lys 270 ctg gtc aag tao Leu Val Lys Tyr ott qcc aag Leu Ala Lys 275 gcc ttg coa Ala Leu Pro ctg ato ttt got Leu Ile Phe Ala aco Thr 285 tca toc tot gaa Ser Ser Ser Glu tot Ser 290 aao oto Asn Leu 295 atg ogo aag atg Met Arg Lys Met oao ato ggt gtg His Ile Gly Val aaa ooa acc gto Lys Pro Thr Val gqa Gly 310 ato gtg gto oca Ile Val Val Pro aoo Thr 315 ggo tat too tto Gly Tyr Ser Phe ttg gao ggo aoo Leu Asp Gly Thr att tao oto aco Ile Tyr Leu Thr goa tot ato tto Ala Ser Ile Phe goc gao gog atg Ala Asp Ala Met aat atg Asn Met 340 1027 1075 1123 1171 1219 oog atq aqo Pro Met Ser goa too aag Ala Ser Lys 360 oto Le u 345 go gag oag gto Gly Glu Gin Val otg ott gto tto Leu Leu Val Phe atg ato ato Met Ile Ile 355 goa aog ttg Aia Thr Leu ggo got got ggt Gly Ala Ala Gly gto Val1 365 tog ggt 900 99t Ser Gly Ala Gly got 900 Ala Ala 375 gga ttg tot toa Gly Leu Ser Ser 090 ooa gaa ott Arg Pro Giu Leu otg Le u 385 oao 990 gtt gac His Gly Vai Asp gt g Val 390 att gtg 990 ato Ile Val Gly Ile ga t Asp 395 aaa tto atg tot Lys Phe Met Ser 900 090 goa ota Ala Arg Ala Leu ac Thr 405 1267 1315 1363 aao tto 900 gga Asn Phe Ala Gly too gtg gca aoa Ser Val Ala Thr otg gtc ggo aag Lou Val Gly Lys tgg act Trp Thr 420 ggo aoo gtg Gly Thr Val ooa ttt gtg Pro Phe Val 440 gao Asp 425 atg aao oaa gto Met Asn Gin Val gao gtt ttg aat Asp Val Leu Asn gga. aaa tot Gly Lys Ser 435 1411 gag tta gaa gaa Glu Leu Glu Giu gao oao Asp His 445 tagttttoaa oaggaogaoa 1458 1461 <210> 426 <211> 446 <212> PRT <213> Corynebacteriur glutamicun <400> 426 Met Asp Ser Asn Thr Glu Ser Ser Ser Val. Giu Val Lys Asn Gin His 1 5 10 Ile Lys Val Gin Lys Pro Pro Lys Lys Asp Arg Thr His Trp Len Tyr 25 Ile Ala Val Ilie Ile Ala Len Ile Gly Gly Ile Thr Leu Gly Len Ile 40 Ser Pro Giu Len Giy Lys Glu Phe Lys Ile Leu Gly Thr Met Phe Val 55 Ser Leu Ile Lys Met Ile Ile Ala Pro Val Ilie Phe Cys Thr Ile Val 70 75 Ile Gly Ile Gly Ser Val Lys Ala Ala Ala Thr Val Gly Arg Ala Gly 90 Giy Ile Ala Leu Ala Tyr Phe Ile Thr Met Ser Thr Phe Ala Leu Ala 100 105 110 Val Gly Leu Len Val Gly Asn Phe Ile Gin Pro Gly Ser Gly Leu Asn 115 120 125 Ile Ser Val Asp Glu Glu Ser Ser Phe Ala Ser Thr Glu Ser Ser Pro 130 135 140 Giu Gly Len Leu Gly Phe Ile His Ser Ile Ile Pro Gin Thr Phe Phe 145 150 155 160 Ser Aia Phe Thr Asp Gly Ser Val Leu Gin Val Len Phe Ile Ala Ile 165 170 175 Leu Val Gly Phe Ala Ala Gin Ser Met Gly Giu Lys Gly Gin Pro Ile 180 185 190 Leu Asp Phe Vai Ser His Leu Gin Lys Le Ile Phe Lys Ile Leu Asn 195 200 205 Trp Ile Leu Trp Leu Ala Pro Val Gly Ala Phe Gly Ala Met Aia Gly 210 215 220 Val Val Giy Glu Thr Gly Phe Asp Ala Val Val Gin Leu Gly Ile Len 225 230 235 240 Ile Len Ala Phe Tyr Val Thr Gys Val Ile Phe Ile Phe Gly Val Leu 245 250 255 Giy Aia Val Len Lys Vai Phe Thr Gly Val Asn Ile Phe Lys Len Val 260 265 270 Lys Tyr Len Ala Lys Giu Phe Len Len Ile Phe Ala Thr Ser Ser Ser 275 280 285 Glu Ser Ala Leu Pro Asn Leu Met Arg Lys Met Giu His Ile Gly Val 290 295 300 Ala 305 Leu Asp Val1 Gly Leu 385 Ala Val1 Leu Lys Asp Ala Phe Ile 370 His Arg Gly Asn Pro Gly Met Met 355 Ala Gly Ala Lys Gly 435 Thr Thr As n 340 Ile Thr Val1 Le u Trp 420 Val1 Ala 325 Met Ile Leu Asp Thr 405 Thr Gly 310 Ile Pro Ala Ala Val1 390 Asn Gly Val1 Le u Ser Lys 360 Gi y Val1 Al a Val1 ValI Thr Leu 34.5 Gly Leu Gly Gly Asp 425 Pro Met 330 Gly Al a Ser Ile Asn 410 Met Thr 315 Al a Glu Al a Ser Asp 395 Ser As n Gi y Ser Gin Gi y His 380 Lys Val1 Gin Tyr I le Val1 Val1 365 Arg Phe Al a Val1 Asn 320 Ala Leu Ala Leu Glu 400 Le u Val1 Lys Ser Pro Phie Val Glu Leu Glu Glu Asp His 445 <210> 427 <211> 620 <212> DNA <213> Corynebacterium glutamicum <220> <2.21> CDS <z222> (55)..(597) <223> RXA01584 <400> 427 ccaccccctt ccccgctacg cgccataccg gcttgggcgg gtg Val1 cca Pro qt t Val1 gaa Glu ttg Leu ttc Ph e cca Pro gac Asp ggC Gly att Ile c t C Leu ttc Phe gca Ala caa Gin ct g Leu cta Leu ctc Leu gga Gly aag Lys gg C Gly gta Val gtq Val1 gtt Val1 q ca Ala gcatcggatc actagtg Val1 1 atg ggc ggg ttt tat Met Gly Gly Phe Tyr ggc ggc ggc cac gtg Gly Gly Gly His Val ccc ggt ttt att aaa Pro Gly Phe Ile Lys cag gca gtq cct ggc Gin Ala Val Pro Gly 55 60 ccc atg ttc agc ttc gcc agc tac ctc ggc gca atc tac ggt ggc atc Pro Met Phe Ser ggt Gi y t tg Leu cgc Arg ttg Le u 130 gt t Val1 t gg Trp t gg Trp gca gtg Ala Val atc agc Ile Ser 100 caa gca Gin Ala gca gcg Ala Ala gca tta Ala Leu att ccg Ile Pro 165- ttg ctt Leu Leu 180 Phe Ala ctg gcc Leu Ala gga atg Gly Met gca gtc Ala Val ctc tac Leu Tyr 135 gct atc Ala Ile 150 ccg tgg Pro Trp Ser agc Ser tac Tyr acc Thr 120 ga t Asp gca Ala gcc Ala Tyr Leu ctg gcg Leu Ala 90 ttt tgg Phe Trp 105 ggc atc Gly Ile ccc gta Pro Val acg gtg Thr Val atc qcc Ile Ala Gly atc Ile gga Gly aac Asn t tc Phe tgt Cys 155 gog Ala Al a ttc Phe cgc Arg gcc Al a acc Thr 140 tgg Trp ggt Gly Tyr ccc Pro cga Arg 110 gtg ValI gg c Gly ggg Gly qcc Al a Gly gcc Ala aaa Lys gtg Val1 atc Ile ct a Le u ctt Leu 175 Ile ct C Leu ccg Pro ctt Le u agc Se r 145 cac His 9gc Gly taqaaaacgc tcagacccaa acc <210> 428 <211> 181 <212> PRT <213> Corynebacterium glutamicum <400> 428 Val Val Phe Leu Gly Ala Leu Leu Gly 1 5 Tyr Pro Ala Phe Ile Gin Ala Gly Ser 25 Val Val Leu Pro Leu.Leu Glu Lys Leu 40 Lys Glu Thr Asp Phe Leu Ser Gly Tyr Gly Pro Met Phe Ser Phe Ala Ser Tyr 70 Ile Gly Gly Ala Val Leu Ala Ser Leu Leu Leu Ser Ile Ser Gly Met Tyr Phe 100 105 Val1 Val1 Val Al a Gly 75 Ile Gly Met Gly Pro Gin Ile Phe Trp Gly Gly Gly Ala T yr Pro Arg 110 Gi y Gi y Phe Val1 Gly Al a Lys Phe His Ile Pro Gly Ala Ala Pro Arg Ile 115 Leu Leu Gly 130 Gin Ala Ala Val Thr 120 Gly Ile Asn Ala VlVa Gy Val Val Gly Ala Ala Leu Asp Pro Val Phe Thr 140 His Gly Ile Thr Ser Val Ser Ala Leu Ala 145 150 Ile Ala Thr Val Trp Leu Giy Leu His Trp Lys Ile Pro Trp Ala Ile Ala Gly Ala Ala Leu Ala 175 Gly Trp Val Leu Leu 180 <210> 429 <211> 813 <212> DNA <213> Corynebacterium glutarnicum <220> <221> CDS <222> (101)..(790) <223> RXA00852 <400> 429 agatcaccgt catggtcata atcgccgctg gagttcatgc agcattccct gacatccgta agaaatagtt ccaacccact tttcctcaga attgcagttc atg ccc gag atc att Met Pro Glu Ile Ile ttt gac aac act Phe Asp Asn Thr gta, cgc tac gat gac tcg ctc att tta Val Arg Tyr Asp Asp Ser Leu Ile Leu gag ccc Glu Pro cta tcg tta Leu Ser Leu ggc gqt gga Gly Gly Giy aaa Lys ctg aca gaa caa Leu Thr Glu Gin cgc Arg 30 att ggc atc: atc Ile Gly Ile Ile ggg gct aac Gly Ala Asn ctc gqc gaa Leu Giy Giu aaa tcc acg ctc Lys Ser Thr Leu aga atg atc aat Arg Met Ile Asn cca acc Pro Thr aca ggg cqt gtt Thr Gly Arg Val qtt gat ggc ctt Val Asp Gly Leu gac Asp gtc tcg cat tcc Val Ser His Ser gga Gly cgg gaa gtt cgc Arg Giu Val Arg aag Lys aag gtt gga ttt Lys Val Gly Phe ttc tct gac gct Phe Ser Asp Ala 307 355 403 aac cag atc gtg Asn Gin Ile Val cca act gtg cgt Pro Thr Val Arg gat att gcc ttc Asp Ile Ala Phe tcg ctt Ser Leu 100 cgc cgg cac Arg Arg His aaa Lys 105 atg cca cgc qct Met Pro Arg Ala gaa Giu 110 aag gcg caa cgt Lys Ala Gin Arg gtc gac gag Val Asp Giu 115 atg atg gcg cga ttc aac ttg agc gag cat gca gat caa tca ccg cac 49 499 Met Met Ala Arg Phe Asn Leu Ser Glu Hi-s Ala Asp Gin Ser Pro His 120 125 130 acc ota tcc ggt ggt caa aag cag ttg tta gcg ctg gct gca gta ctg 547 Thr Leu Ser Gly Gly Gin Lys Gin Leu Leu Ala Leu Ala Ala Val Leu 135 140 145 att ttg gag cca gaa gtg atc ato gct gat gag ccc act acc ctg ctg 595 Ile Leu Giu Pro Glu Val Ile Ile Ala Asp Giu Pro Thr Thr Leu Leu 150 155 160 165 gat ctg cgc aat agg ctg atg atc aaa gac gtg ttc aat aaa ctc gag 643 Asp Leu Arg Asn Arg Leu Met Ile Lys Asp Val Phe Asn Lys Leu Glu 170 175 180 cag caa tta atc gtt gtc agc cat gat tta gat ttc ctc agc gat ttt 691 Gin Gin Leu Ile Val Val Ser His Asp Leu Asp Phe Leu Ser Asp Phe 185 190 195 gag cgg gtc att tgc atc aat gat cat aaa atc got gct gat ggc cot 739 Glu Arg Val Ile Cys Ile Asn Asp His Lys Ile Ala Ala Asp Gly Pro 200 205 210 ccg caa aag too att gao ctg tao gta tog ctt atg gog gaa cct gcg 787 Pro Gin Lys Ser Ile Asp Leu Tyr Val Ser Leu Met Ala Glu Pro Ala 215 220 225 aaa. tgaaoagtat tcctttaggt ttt 813 Lys 230 <210> 430 <211> 230 <212> PRT <213> Corynebacterium giutamicum <400> 430 'Met Pro Giu Ile Ile Phe Asp Asn Thr Giu Val Arg Tyr Asp Asp Ser 1 5 10 Leu Ile Leu Giu Pro Leu Ser Leu Lys Leu Thr Glu Gin Ar Ile Gly 25 Ile Ile Gly Ala Asn Gly Gly Gly Lys Ser Thr Leu Ile Arg Met Ile 40 Asn Gly Leu Gly Giu Pro Thr Thr Gly Arg Val Leu Val Asp Gly Leu 55 Asp Val Ser His Ser Gly Arg Giu Val Arg Lys Lys Val Gly Phe Val 70 75 Phe Ser Asp Ala Giu Asn Gin Ile Val Met Pro Thr Val Arg Giu Asp 90 Ilie Ala Phe Ser Leu Arg Arq His Lys Met Pro Arg Ala Glu Lys Ala 100 105 110 Gin Arg Val Asp Giu Met Met Ala Arg Phe Asn 115 120 Asp Gin Ser Pro His Thr Leu Ser Gly Gly Gin 130 135 Leu Ala Ala Val Leu lie Leu Glu Pro Giu Val 145 150 155 Pro Thr Thr Leu Leu Asp Leu Arg Asn Arg Leu 165 170 Phe Asn Lys Leu Giu Gin Gin Leu Ile Val Val 180 185 Phe Leu Ser Asp Phe Glu Arg Val Ile Cys Ile 195 200 Ala Ala Asp Gly Pro Pro Gin Lys Ser Ile Asp 210 215 Met Ala Glu Pro Ala Lys 225 230 <210> 431 <211> 1269 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1246) <:223> RXA00690 (400> 431 atggatcatt ggactcacac tggctqtcat ttccttggtt gtgggcgatt cgtcqttcag aqgtccaggg ttaaagcttc Le u Lys 140 Ile Met Ser As n Leu 220 Ser 125 Gin Ile Ile His Asp 205 Tyr His Le u Asp Asp 175 Le u Lys Ser tat Tyr gcg Ala ttg Le u ggg Gly ggt Gly ctg Leu ggt Gly ctc Leu tcg Ser ct C Leu c9g Arg gct Ala ttt Phe t gg T rp gtg ValI cgg Arg ggt Gly gcc Ala t cg Ser 60 tac Tyr gt t Val gc Al a 30 ttq Leu gct Ala ttg Leu tcaqcgtctg ctgtggcggc gtq aaa tgg att gag Val Lys Trp Ile Glu 1 tgg gcg tgg tgg gtg Trp Ala Trp Trp Val acc aac aat Cct tat Thr Asn Asn Pro Tyr gtg qtg ttt aac cgt Val Val Phe Asn Arg atc tat ttg atg atc Ile Tyr Leu Met Ile cac att gtg qtg qga His Ile Val Val Gly 115 163 211 259 307 355 gca aaa att ggc Ala Lys Ile Gly acc Thr att gaa ctg ttt Ile Giu Leu Phe atc ccg ccg gtg Ile Pro Pro Val cag ttg Gin Leu 100 403 ccg gaa tgg Pro Glu Trp ggt ctg atc Gly Leu Ile 120 gct Al a 105 gcg ggt atc cac Ala Gly Ile His gtg Val1 110 ttt qgc acg gtg Phe Gly Thr Val tat ctc gag Tyr Leu Giu 115 acg atg atc Thr Met Ile 451 499 atc gcg acg acg Ile Ala Thr Thr ggc tta acg ctt Gly Leu Thr Leu gga Gly 130 gtg gcg Val Ala 135 gtg ggt gct gcg Val Gly Ala Ala tct ttg gcg gat Ser Leu Ala Asp ccc Pro 145 aag aaq ctq ctc Lys Lys Leu Leu tcg ttg cct ggc Ser Leu Pro Gly gca Al a 155 ttg gqc gaa ctg Leu Gly Giu Leu act gcg gtg gtc Thr Ala Val Val 547 595 643 ggt att tcc att Gly Ile Ser Ile cct cag atg gct Pro Gin Met Ala gag Glu 175 tcg gcg ttc cgc Ser Ala Phe Arq att aat Ile Asn 180 cgt gca cga Arg Ala Arg gcg cgg att Ala Arg Ile 200 acc Thr 185 ttg cgt ggt gat Leu Arg Gly Asp ga t Asp 190 gcc aaa ggt gtt Ala Lys Gly Val cgt ggt ttc Arg Gly Phe 195 agg tct ttg Arg Ser Leu 691 739 ttg atg ccg gtt Leu Met Pro Val cag gac act ttg Gin Asp Thr Leu gat Asp 210 gcc ctg Ala Leu 215 gct aat tcc atg Ala Asn Ser Met gcc cgt ggt tat Ala Arg Gly Tyr ggc Gly 225 agg cag gct cat Arg Gin Ala His tcc aaa ttc caa Ser Lys Phe Gin ca g Gin 235 cgt gtg acc tct Arg Val Thr Ser ttt ggt gca ttc Phe Gly Ala Phe gga Gly 245 ata ctc qgc gtg Ile Leu Gly Val gtt ggt ctg ttt Val Gly Leu Phe gt g Val 255 qtc tta gat gca Val Leu Asp Ala tca tca Ser Ser 260 ccg atg ttc Pro Met Phe atc att tcg Ile Ile Ser 280 gt t Val1 265 gcc qtt ccg gtg Ala Val Pro Val att acc ggc gtg Ile Thr Gly Val gqc ttc ttq Gly Phe Leu 275 acc act ttt Thr Thr Phe ttg gtc gtt gct Leu Val Val Ala cat aga aaa aca His Arg Lys Thr tcc Ser 290 gat cag Asp Gin 295 ttg cct tgg ggt Leu Pro Trp Gly gcg gaa tgg ctt Ala Giu Trp Leu gt g Val1 305 tgc atc aca qgt Cys Ile Thr Gly 1027 att ccg ctg ctc atq gct gcg ctg aca Ile Pro Leu Leu Met Ala Ala Leu Thr 315 tac ctt gat cca Tyr Leu Asp Pro 1075 tcc Ser ttg Le u a cg Thr ata. Ile a tg Met ctc Leu ccc Pro aat Asn 375 atc Ile gt t Val1 cgc Arg 360 agc Se r acc Thr 330 tgg gtt cct ttg Trp Val Pro Leu gtg gca gga ctt gtt Val Ala Gly Leu Val. 345 ttg ccg aag aac aaa Leu Pro Lys Asn Lys 365 cca gaa agg gcc gaa Pro Glu Arg Ala Glu 380 cat atg cca gac acc gtt ccg His Met Pro Asp Thr Val Pro 335 340 gcg acg atg cca gga ttc ttg Ala Thr Met Pro Gly Phe Leu 355 agg gtc aag cgt cga aaa gca Arg Val Lys Arg Arg Lys Ala 370 taatgagtgc tccttttagc 1123 1171 1219 1266 gcg (210> 432 <211> 382 <212> PRT <213> Corynebacterium glutamicum <400> 432 1269 Val Lys Trp Ile Glu Arg Tyr Val 1 Trp Thr Val1 Ile His Pro Thr Le u Pro 145 Thr Al a Asn Val1 so Tyr Ile Pro Val. Gi y 130 Lys Ala Trp Asri Phe Leu Val1 Val1 Tyr 115 Thr Lys Val1 Trp Pro Asn Met Val1 Gin 100 Le u Met Le u Val1 Ile 180 5 Val1 Tyr Arg Ile Gi y Leu Glu Ile Leu Ile 165 Trp Ile Arg Ala 70 Ala Pro Gly Val1 Lys 150 Gly Ala Leu Gly 55 Gly Lys Glu Leu Ala 135 Ser Ile Leu Ser 10 Gly Ile Leu Thr Ser Pro Leu Val. Gly Thr 90 Ala Ala 105 Ile Ala Gly Ala Pro Gly Ile Ala 170 Arg Ala Phe Trp Val1 Ile Gly Thr Al a Ala 155 Pro Ar g Gly Al a Ser Tyr Glu Ile Thr As n 140 Le u Gin Met Cys Thr Arg Arg Leu His Gin 125 Ser Gi y Met His Ser Cys Phe Val1 Arg Phe Leu Al a Le u Glu 175 Ala Phe Arg Asn Arg Ala Arg Leu Arg Gly Asp Asp Ala Lys 190 Gly Val Arg 195 Leu Asp Arg 210 Gly Arg Gin 225 Phe Gly Ala Leu Asp Ala Gly Val Gly 275 Thr Ser Thr 290 Val Cys Ile 305' Tyr Leu Asp Pro Asp Thr Met Pro Gly 355 Lys Arg Arq 370 <210> 433 Gi y Ser Al a Phe Ser 260 Phe Thr Thr Pro Val1 340 Phe Arg Le u 215 Ser Leu Met Ile Gin 295 Ile Met Le u Pro Ile 200 Al a Lys Gly Phe Ser 280 Leu Pro Ile Val Arg 360 Met Se r Gl n Thr 250 Al a Val1 Trp Leu Th r 330 Ala Pro Pro Met Gin 235 Val Val1 Val1 Gly Met 315 T rp Gly Lys Gin Arg Thr Phe Phe 270 His Giu Le u Leu Val1 350 Val Lys Ala Ile Asn Ser Pro Glu Arq 375 Ala Glu Vai 380 <211> 876 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <z222> (101)..(853) <z223> RXA00827 (400> 433 tgcgtgaatt aacagacaac ggaatcagca ttgtgtcagt aacccatgat cctgatttca tcgcagcgct gggcgatcac cacattgagg tgagcgcgaa gtg aac ctg ctg atc Val Asn Leu Leu Ile 1 aaa att aat ccc gtc acc cgc atc atc gcg ttg atq gta ctg acc acg Lys Ile Asn Pro Val Thr Arg Ile Ile Ala Leu Met Val Leu Thr Thr 15 ccg ttg ctq ctg agt ttg gat gtq atg tcg gca gcg atc gcg ctg gtg Pro Leu Leu Leu Ser Leu Asp Val Met Ser Ala Ala Ile Ala Leu Val 30 gCa acc att Ala Thr Ile att ctg gca cca Ile Leu Ala Pro gcc ggc gtg acc Ala Gly Val Thr aag atg ctg Lys Met Len ctg aaa Leu Lys cgt ggc tgg atg Arg Gly Trp Met ttc ctc atg gca Phe Leu Met Ala gtg gct gca tta Val Ala Ala Leii t cc Ser atg gcg ctt tat Met Ala Leu Tyr ggC Gly aqg ccq gat gga Arg Pro Asp Gly gag tac ttt agc Glu Tyr Phe Ser ctg ctc att cac Leu Leu Ile His act gat aat tca Thr Asp Asn Ser ctg Leu gct ttg gct gct Ala Leu Ala Ala gcc att Ala Ile 100 ggg ctg cgt Gly Leu Arg cgc att gat Ar Ile Asp 120 ctg gcg att ggt Leu Ala Ile Gly CCC gtt gtg gtg Pro Val Val Val ctg att gct Leu Ile Ala 115 ctg ctc aaa Leu Len Lys ccc aco gac ctg Pro Thr Asp Leu gat ggt ttg qcg Asp Gly Leu Ala ca g Gin 130 ctg Cct Leu Pro 135 gaa agg ttt gtc Gin Arg Phe Val atc Ile 140 ggt gct gtg gca Gly Ala Val Ala ago cga ctg atg Ser Arg Len Met ctt ttt cgg gaa Leu Phe Arg Gin gat Asp 155 tgg tac tcc atg Trp Tyr Ser Met t cc Ser 160 agg gca agg cgt Arg Ala Arg Arg gcc Ala 165 cgc gga att qct Arg Gly Ile Ala cag gqc aag atc Gin Gly Lys Ile cac ttt ttc aec His Phe Phe Thr atg act Met Thr 180 ttt ggt ttg Phe Gly Len gcg atg gaa Ala Met Gin 200 gtg ctc tcg ctt Val Leu Ser Leu cgt gga tcc aag Arg Gly Ser Lys ctt gca acg Len Ala Thr 195 acc tgg gca Thr Trp Ala gca cgc ggt ttt Ala Arg Gly Phe gg t Gi y 205 cgc acq act gqc Arq Thr Thr Gly cgc Ar g 210 agg gaa Arq Gin 215 tcc acc gtc ggc Ser Thr Vai Gly cgc gat ctg gtg Arg Asp Len Val atc ttg gtg tgt Ile Leu Val Cys gcc att tcc gcg Ala Ile Ser Ala atc Ile 235 gct cta acc gtgj Ala Leu Thr Val t CC Ser 240 att cag act ggt Ile Gin Thr Gly ttc Phe 245 ttt aaq ttc ttg Phe Lys Phe Leu ggc aca Gly Thr 250 tgatcacagt tttaattgat gqa <210> 434 <211> 251 <212> PRT (213> Corynebacterium glutamicum <400> 434 Val1 Met Al a Thr Pro Glu Leu Val1 Al a Gly 145 Arg Phe Ser Gly Leu 225 Ile Leu Leu Ala Lys Al a Phe Ala Leu 115 Leu Arg Arg Thr Leu 195 Thr Leu Thr Leu Thr Le u Met Ala Se r Ala 100 Ile Leu Leu Arg Met 180 Al a Trp Val1 Gly Lys Pro Al a Leu Ser 70 Leu Gly Arg Leu Thr 150 Arg Phe Al a Arg Al a 230 Phe Ile Asn Pro Val Thr Arg Ile Ile Ala Leu Leu Thr Lys Met Le u Le u Ile Pro 135 Leu Gly Gly Met Glu 215 Al a Lys Ser Leu Trp Tyr Val1 Leu Thr Phe Glu Asp 170 Val1 Arg Val1 Al a Gly 250 Asp Pro Leu Arg Asp Ile Leu Ile 140 T rp Gly Ser Phe Ala 220 Ala Val1 Phe Phe Pro Asn Gly Gly 125 Gly Tyr Lys Leu Gly 205 Arq Leu is Ser Gly Met Gly Leu Pro Gly Val1 Met Lys 175 Arg Thr Leu Val1 Ala Val1 Ala Lys Ala Val1 Leu Ala Ser 160 His Gly Thr Val Ser 240 <210> 435 <211> 732 (212> DNA <213> Corynebacteriun glutamicum <220> (221> CDS <222> (101)..(709) <223> RXA00851 <400> 435 ttgagcgqgt catttgoatc aatgatcata aaatcgctgc coattgacct gtacgtatcg cttatqgcgg aacctgcgaa tgatggccct ccgcaaaagt atg aac agt att Met Asn Ser Ile 1 tta ggt ttt tac Leu Giy Phe Tyr gat aag caa tot Asp Lys Gin Ser gtt oat tot ttt Val His Ser Phe oot got Pro Aia ttg tgg aaa Leu Trp Lys gog got tot Ala Ala Ser tto Phe ooa ott ctg otg Pro Leu Leu Leu ttt Phe 30 tto ato ato ggo Phe Ile Ile Gly ggo too ato Gly Ser Ile att goa gtg Ile Ala Val 211 259 aoo oog gtt oat Thr Pro Val His ttg att ttg gtg Leu Ile Leu Val gtg ttt Val Phe tao gtg otg gog Tyr Vai Leu Ala att cog ctg aag Ile Pro Leu Lys gog tgq gag oag Ala Trp Glu Gin tgg ooa gtg otg Trp Pro Val Leu att ttg ato atg Ile Leu Ile Met oto Leu ggt gcg ttt cag Gly Ala Phe Gin tgg cag ogo ggo Trp Gin Arg Gly ftot Phe gat tto gcg goa Asp Phe Ala Ala aoa qtg oto aog Thr Val Leu Thr otg ttt Leu Phe 100 too gog gtg Ser Ala Val gog oto atg Ala Leu Met 120 goo goc atg ttg Ala Ala Met Leu ttg Leu 110 aog ttg aoo aog Thr Leu Thr Thr oqq ttg gaa Arg Leu Glu 115 goa ogt ttt Ala Arg Phe 307 355 403 451 499 547 595 643 aat goa gtt gag Asn Ala Val Giu atg ttg oag oat Met Leu Gin Pro ggc otg Giy Leu 135 coa gta gag aog Pro Val Glu Thr aco tog got att Thr Leu Ala Ile oto aog att ogg Leu Thr Ile Arg oto Leu 150 att oog otg oaa Ile Pro Leu Gin o ta Leu 155 goo aog gtg aag Ala Thr Val Lys ga a Glu 160 gto oto gat gc Val Leu Asp Ala aaa got ogt ggt Lys Ala Arg Gly ggt ttt tot atc Gly Phe Ser Ile gcg ttt ggo acg Ala Phe Gly Thr cot gtg Pro Val 180 ato ato aqa Ile Ile Arq goa ogt ggt Ala Arq Gly 200 ata aaq agq gc Ile Lys Arg Ala ogo Arg 190 aat ato ggo gat Asn Ile Gly Asp got ott oto Ala Leu Leu 195 goc ggc gat taatttottt oaaoaoatag oaa. Ala Gly Asp <210> 436 <211> 203 <212> PRT <213> Corynebacterium giutamicum <400> 436 Met Asn Ser 1 His Ser Phe Ile Gly Giy Val Gly Ile Val Ala Trp Gly Ala Phe Val Leu Thr Thr Thr Arg 115 Pro Phe Ala 130 Ser Leu Thr 145 Val Leu Asp Phe Gly Thr Gly Asp Ala 195 <210> 437 <211> 725 <212> DNA Pro Leu Giy Phe Ala Ile Val1 Gin T rp Phe Giu Phe Arg Arg 165 Val Leu Al a Val1 Leu 70 Trp Ser Al a Gi y Le u 150 Lys Ile Tyr Phe Thr Val1 Val1 Gly Met 105 Asn Val Leu Gly Ser 185 Asp Leu Val1 Al a Pro 75 Asp Ala Val Thr Leu 155 Giy Lys Gin Leu Gly Ile Le u Al a Leu Arg 125 Thr Thr Ser Ala Val1 Ile Leu Lys Le u Thr Le u Gin Ile Glu 160 Al a Ile Leu Leu Ala Arg Gi Ala Giy Asp <213> <220> <221> <222> <223> <400> ccatg Met 1 Corynebacterium giutamicum CDS RXSO03220 437 ggc tta agg gaa att ttg tcc agc aag tqg ctt gtg cqc atc ctc Gly Leu Arg Giu Ile Leu Ser Ser Lys Trp Leu Val Arg Ile Leu 5 10 gta ggt atc gga ttg ggt gte gca cag cag ctg ace ggc ate aac Val Gly Ile Gly Leu Gly Val Al a 25 Gin Gin Leu Thr Gly Ile Asn ggt ttc tcc Gly Phe Ser tee atc atg Ser Ile Met tac tac ggc cag Tyr Tyr Gly Gin gtt ctc at: gag Val Leu Ile Glu gct Al a gag aat Giu Asn gca gct ctg atc Ala Ala Leu Ile gcc Al a aac gtg gcg cca Asn Val Ala Pro gtg atc gca gtt Val Ile Ala Val gtc ValI ggt gca ttc atc Gly Ala Phe Ile ctg tgg atg atg Leu Trp Met Met ggt atc aac cgc Gly Ile Asn Arg cg t Arg ace acc etc att Thr Thr Leu Ile a cc Thr ggt tat tct etc Gly Tyr Ser Leu acc att agc cac Thr Ile Ser His gta ttg Val Leu ato ggt atc Ile Gly Ile tac gtt atc Tyr Val Ile 115 tcc gta gca tte Ser Val Ala Phe cca Pro 105 gte ggc gat cct Val Gly Asp Pro ctt cgc ccc Leu Arg Pro 110 atg cag ac Met Gin Thr ttg act ctg gtt Leu Thr Leu Val qtg Val1 120 gte ttc gtg gga Val Phe Val Gly tee Se r 125 tte etc Phe Leu 130 aae qta get ac Asn Val Ala Thr tgg Trp 135 gtt atg ctc tct Val Met Leu Ser ctc ttc ccg ctg Leu Phe Pro Leu gca Al a 145 atg cgc ggt tte Met Arg Gly Phe atc gqt ate tca Ile Gly Ile Ser ttc ttc ctc tgq Phe Phe Leu Trp ate Ile 160 gca aac geg tc Ala Asn Ala Phe ctc Leu 165 gga ttg ttc tte Gly Leu Phe Phe ace ate atg gaa Thr Ile Met Giu gca gta Ala Val 175 gga eta ace Gly Leu Thr ttg ate ttc Leu Ile Phe 195 ace tte ttc atg Thr Phe Phe Met tte Phe 185 gee gga ate ggt Ala Gly Ile Gly gtg gtt gee Val Val Ala 190 cgt ace ttg Arg Thr Leu ate tac ace eag Ile Tyr Thr Gin cet gaa act cgt Pro Giu Thr Arg gga Gi y 205 gag gag Giu Glu 210 att gat gag gat Ile Asp Glu Asp act tee ggt gte Thr Ser Gly Val tte aae aag gac Phe Asn Lys Asp ega aaa gga aag Arg Lys Gly Lys gtg cac Val His 230 taaaaaeeea gaeaetgeat agataaeacg <210> 438 <211> 231 <212> PRT <213> Corynebacterium glutamicum <400> 438 Met Gly Leu Arg Glu Ile Leu Ser Ser Lys Trp Leo Val Arg Ile Leu 1 5 10 Leu Val Gly Ile Gly Leo Gly Val Ala Gin Gin Leu Thr Gly Ile Asn 25 Ser Ile Met Tyr Tyr Gly Gin Val Val Le Ile Glu Ala Gly Phe Ser 40 Giu Asn Ala Ala Leu Ile Ala Asn Val Ala Pro Gly Val Ile Ala Val 55 Val Gly Ala Phe Ile Ala Leu Trp Met Met Asp Gly Ile Asn Arg Arg 70 75 Thr Thr Leu Ile Thr Gly Tyr Ser Leo Thr Thr Ile Ser His Val Leo 90 Ile Gly Ile Ala Ser Val Ala Phe Pro Val Gly Asp Pro Leo Arg Pro 100 1.05 11.0 Tyr Val Ile Leu Thr Leo Val Val Val Phe Val Gly Ser Met Gin Thr 115 120 125 Phe Leu Asn Val Ala Thr Trp Val Met Leu Ser Glu Leo Phe Pro Leu 130 135 140 Ala Met Arg Gly Phe Ala Ile Gly Ile Ser Val Phe Phe Leo Trp Ile 145 150 155 160 Ala Asn Ala Phe Leu Gly Leo Phe Phe Pro Thr Ile Met Giu Ala Val 165 170 175 Gly Leu Thr Gly Thr Phe Phe Met Phe Ala Gly Ile Gly Val Val Ala 180 185 190 Leu Ilie Phe Ile Tyr Thr Gin Val Pro Glu Thr Arg Gly Arg Thr Leo 195 200 205 Glu Giu Ilie Asp Glu Asp Vai Thr Ser Giy Vai Ile Phe Asn Lys Asp 210 215 220 Ile Arg Lys Gly Lys Val His 225 230 <210> 439 <211> 408 <212> DNA <213> Corynebacterium glotamicum <~220> <221> CDS <222> (385) <223> FRXA02762 <400> 439 ttcccagtcg gcgatcctct tcqcccctac gttatcttga ctctggttgt ggtcttcgtg ggatccatgc agaccttcct caacggtagc tacctgc ttc ccg ctg gca atg cqc ggt ttc qca Phe Pro Leu Ala Met Arg Gly Phe Ala ctc tgg atc gca aac gcg ttc ctc gga Leu Trp Ilie Ala Asn Ala Phe Leu Gly 30 gaa goa gta gga ota acc gga acc ttc Giu Ala Val Gly Leu Thr Gly Thr Phe 45 gtg gtt gcc ttg atc: ttc ato tao aco Val Val Ala Leu Ile Phe Ile Tyr Thr 60 cqt acc ttg gag gag att gat gag gat Arg Thr Leu Glu Giu Ile Asp Giu Asp 75 aac aaq gac atc: cga aaa qga aag gtg Asn Lys Asp Ile Arg Lys Gly Lys Val aga <210> 440 <211> <212> PRT <213> Corynebacterium glutamicum <400> 440 Met Leu Ser Giu Leu Phe Pro Leu Ala 1 5 Ile Ser Val Phe Phe Leu Trp Ile Ala 2S Phe Pro Thr Ile Met Giu Ala Val Gly Phe Ala Gly Ilie Gly Val Val Ala Leu 55 Pro Glu Thr Arg Gly Arg Thr Leu Glu Ser Gly Val Ilie Phe Asn Lys Asp Ile '<210> 441 <211> 789 (212> DNA <213> Corynebacterium giutamicum ;gtt atg ctc tot gag ctc Met Leu Ser Giu Leu 1 qgt ato toa gtg ttc ttc Gly Ile Ser Val Phe Phe ttc ttc coa aco ato atg Phe Phe Pro Thr Ile Met atg tto gco: gga ato ggt Met Phe Ala Gly Ile Gly gtt cot gaa act ogt gga Val Pro Glu Thr Arg Gly act tcc ggt gtc att ttc Thr Ser Gly Val Ile Phe 80 taaaaaoooa qacactgcat 115 163 211 259 307 355 405 Gly Phe Gly Ile Asp Gly Ala Gly Phe Thr Asp Val Ile Leu Phe Gin Val1 His <220> (221> CDS <222> (101)..(766) <223> RXN00092 (400> 441 cgaaaccaga aacacccagc ggctcctcgt cgaaaagcga ggcacgttgg ctcgaocgaa ttgaagcatt ggagcagtaa atctttgaac tagaagccca atg aca aac acg cct 11! Met Thr Asn Thr Pro ttc ccc ctt gaa Phe Pro Leu Glu ct t Le u caa aac atc Gin Asn Ile tcc tgC Ser Cys 15 gtc tcq Val Ser gcc: ttc: gga gaa Ala Phe Gly Giu ggc cca Gly Pro cgc cac qtc Arg His Val gaa ctc gtt Glu Leu Val gcg ctc: aac aac Ala Leu Asn Asn ctg gca gto Leu Ala Val aat ccc ggc Asn Pro Gly tcc acc ttg Ser Thr Leu gcc atc: atg ggc Ala Ile Met Gly tcc ggc tca gga Ser Gly Ser Gly aaa Lys ctc aac Leu Asn gtc gcc gc ctc Val Ala Gly Leu ctg Le u cag cgc gca acc Gin Arg Ala Thr ggc cat gtg ctt Gly His Val Leu 211 259 307 355 403 gac ggt goc agc Asp Gly Ala Ser tca gac ctc aac Ser Asp Leu Asn gcc Ala aaa cgc qca gct Lys Arg Ala Ala acc agg cgt cgc Thr Arg Arg Arg cac His atc ,gga gtt att Ile Gly Vai Ile caa aac tac aac Gin Asn Tyr Asn ctg gtc Leu Val 100 ccc acc cto Pro Thr Leu ggc aaa acc Gly Lys Thr 120 gto gga gaa aac Val Gly Giu Asn ggt ctg ccc cta Gly Leu Pro Leu gaa ctc gac Giu Leu Asp 115 gaa gtc ggc Giu Val Gly gac cgc cag gca Asp Arg Gin Ala gca atc gca ctc Ala Ile Ala Leu gog Al a 130 ctc gaa Leu Giu 135 ggc ttc gao gao Gly Phe Asp Asp cgc Arq 140 ttc ccc gaa gag Phe Pro Giu Glu too ggc ggc caa Ser Gly Gly Gin cag cgc gtc gc Gin Arg Val Ala ato Ile 155 gcg aga gcc oto Ala Arg Ala Leu atc Ile 160 ggc ccc oga aaa Gly Pro Arg Lys ttg ctt gcc gao Leu Leu Ala Asp gaa Giu 170 coo aco ggc gc Pro Thr Gly Ala gac acc tcc aco Asp Thr Ser Thr ggc gac Gly Asp 180 gca gto cto Ala Val Leu gto ctc cgc caa Val Leu Arg Gin atc gat too: ggt Ile Asp Ser Gly goc gca ggc Ala Ala Giy 195 cto: ott gtc aco cac: gaa 000 ogo ttc goc gog tgg gca gao cga aca Leu Leu Val Thr His Glu Pro Arg Phe Ala Ala Trp Ala Asp Arg Thr 200 205 210 atc atg ctt agg gat ggt gaa atc cag. tgaccacact tctagcagca 786 Ile Met Leu Arg Asp Gly Giu Ile Gin 215 220 acc 789 <210> 442 <211> 222 <212> PRT <213> Corynebacterium giutamicum (400> 442 Met Thr Asn Thr Pro Phe Pro Leu Giu Leu Gin Asn Ile Ser Cys Ala 1 5 10 Phe Gly Giu Gly Pro Arq His Val Ser Ala Leu Asn Asn Val Ser Leu 25 Ala Val Asn Pro Gly Giu Leu Val Ala Ile Met Gly Pro Ser Gly Ser 40 Gly Lys Ser Thr Leu Leu Asn Val Ala Gly Leu Leu Gin Arq Ala Thr 55 6C Ser Gly His Val Leu Ile Asp Giy Ala Ser Ala Ser Asp Leu Asn Ala 70 75 Lys Arg Ala Ala Glu Thr Arg Arg Arg His Ile Gly Val Ile Phe Gin 90 Asn Tyr Asn Leu Val Pro Thr Leu Thr Val Gly Giu Asn Val Gly Leu 100 105 110 Pro Leu Giu Leu Asp Gly Lys Thr Asp Arg Gin Ala Val Ala Ile Ala 115 120 125 Leu Ala Giu Val Gly Leu Giu Gly Phe Asp Asp Arq Phe Pro Glu Giu 130 135 140 Ile Ser Gly Gly Gin Ala Gin Arg Val Ala Ile Ala Arg Ala Leu Ile 145 150 155 160 Gly Pro Arg Lys Ile Leu Leu Ala Asp Giu Pro Thr Gly Ala Leu Asp 165 170 175 Thr Ser Thr Gly Asp Ala Val Leu Arg Val Leu Arg Gin Arg Ile Asp 180 185 190 Ser Gly Ala Ala Gly Leu Leu Val Thr His Giu Pro Arg Phe Ala Ala 195 200 205 Trp Ala Asp Arg Thr Ile Met Leu Arg Asp Gly Giu Ile Gin 210 215 220 <210> 443 <211> 227 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> <223> FRXA00092 <400> 443 ate gcg aga gee ctc atc ggc ccc Ile Ala Arg Ala Leu Ile Gly Pro cqa aaa ate Arg Lys Ile ttg ctt gcc Leu Leu Ala gac gaa Asp Glu ce aec gge Pro Thr Gly etc cgc caa Leu Arg Gin gee Al a etc gac ace tee Leu Asp Thr Ser ace ggc gac gea Thr Gly Asp Ala 25 gee gca gge etc Ala Ala Gly Leu gte etc ego gte Val Leu Arq Val aga ate gat tee Arg Ile Asp Ser gte ace eac Val Thr His gaa ccc Glu Pro ege ttc gee geg Arg Phe Ala Ala gca gac ega aca Ala Asp Arg Thr ate Ile atg ctt agg gat Met Leu Arg Asp ggt gaa ate cag tgaeeaeact tctagcagea ace Gly Glu Ile Gin <210> 444 <211> 68 <212> PRT <213> Corynebacterium glutamicum <400> 444 Ile Ala Arg 1 Pro Thr Gly Ala Leu Ile Gly Pro Arg 5 Lys 10 Ile Leu Leu Ala Asp Giu Leu Asp Thr Ser Gly Asp Ala Vai Leu Arg Val Val Thr His Leu Arg Gin Arg Ile Asp Ser Ala Ala Gly Leu Giu Pro Arg Phe Ala Ala Ala Asp Arg Thr Ile Met Leu Arg Asp Giy Giu Ile Gin <210> 445 <211> 975 <212> DNA <213> Corynebacterium giutamicum <220> <221> <222> <223 C DS (101)..4952) RXN0 3060 <400> 445 tatgtccttt ggctccggta coctggoagg agtacctggg gacgttttca agattgaatt. taaggaaagc atcgtagttc ctgtttttct aaaatggoot atg agt aao cct goo 11 Met Ser Asn Pro Ala gcg ago aca cot Ala Ser Thr Pro gc Ala aac aat tog gac Asn Asn Ser Asp gtt gcg aag gag Vai Ala Lys Giu aat tgg Asn Trp gao tot tot Asp Ser Ser aat aao tog Asn Asn Ser acg ocg aag aot Thr Pro Lys Thr att, gao tot too Ile Asp Ser Ser oag oct gto Gin Pro Val otg tac aag Len Tyr Lys sot ggt gaa goo got gog ogo gos gtg Thr Gly Giu Ala Ala Ala Arg *Ala Val gog tat Ala Tyr ggo oag ggt gat Gly Gln Gly Asp act gto soc gog Thr Val Thr Ala ttg Le u gat cac gto aao Asp His Vai Asn gag ttt gag aag Giu Phe Giu Lys aag tto sot gc Lys Phe Thr Ala stg ggt cot tot Met Gly Pro Ser tog ggt aag too Ser Gly Lys Ser a cg Thr ttg atg oso tgo Leu Met H is Cys got ggt otg gat Ala Gly Leu Asp got. gog Ala Ala 100 ttg sag Len Lys act ggt ggt Thr Gly Gly gao aaa gag Asp Lys Gin 120 gca ttc att gqt Ala Phe Ile Giy acg gat otg tog Thr Asp Leu Ser stg aoc tot ttg Met Thr Ser Leu cgt Arg 125 ogt gat ogt ttg Arg Asp Arg Leu tto att tto Phe Ile Phe cag tog Gin Ser 135 tto aac ttg gtt Phe Asn Leu Val act otg acg gcg Thr Len Thr Ala gag sac att. sog Giu Asn Ile Thr 499 547 595 643 cot aco gat ato Pro Thr Asp Ile gog Ala 155 ggc ogo aag att Gly Arg Lys Ile ga t Asp 160 cag tog tgg ttc Gin Ser Trp Phe gag att sco tot Gin Ile Thr Ser og t Arg 170 otg ggt otg act Leu Gly Leu Thr ogo ott sag cac Arg Len Lys His ogt oct Arg Pro 180 gca gag oto Ala Giu Len ttg gtg tot Len Val Ser 200 ggt ggt cag cag Gly Gly Gin Gin ogt gtg gog tgt Arg Val Ala Cys got ogt gog Ala Arg Ala 195 soc ggt aac Thr Gly Asn ogt ocg gag ato Arg Pro Gin Ilie att Ile 205 tto ggo gao gag Phe Gly Asp Gin ttg gat tog aac tot tot. agg gsa gtg ctg gat ato otg ogo aco gca Le u gtt Val1 230 gcg Al a gtg Val1 aac As n Ser Asn cag gat Gin Asp tcc tat Ser Tyr eag ttg Gin Leu 265 att gag Ile Glu 280 Ser Ser Arg 220 gat cag ace Asp Gin Thr 235 gca gat cgt Ala Asp Arg 250 ttt gat ec Phe Asp Pro gat att gcc Asp Ile Ala Glu Val Leu Asp Ile Leu Arg Thr Ala 225 gtt gtg atc gtt ace cac gat gee aag Val Val Ile Val Thr His Asp Ala Lys 240 245 gtc att ttc ttg gcg gac ggt cgt ate Val Ile Phe Leu Ala Asp Gly Arg Ile 255 260 ace ate gag gaa ate ttg gcc acg atg Thr Ile Glu Giu Ile Leu Ala Thr Met 270 275 taatgaattc eggttccaca atg <210> 446 <211> 284 <2i2> PRT <213> Corynebacterium giutamicum <400> 446 Met Ser Asn Pro Ala Ala Ser Thr Pro Lys Se r As n Asp Gi y Le u Ser Giy 130 Gi u Se r Trp Val1 Lys Asn Gly Al a Lys Phe Thr Asp 165 Se r As n Tyr Glu Gi y Gly Lys Ser 135 Pro Ile Ala Thr Gly Gly Lys Thr Ala Thr Le u Ile Arg 170 Gly Asn Pro Giu Asp Asn Leu Phe Ser Val1 Ala 155 Leu Gly Ser Thr Ala Thr Phe His Gly Arg 125 Thr Arg Leu Gin Asp Asp Al a Val1 Thr Cys Asp 110 Arg Leu Lys Thr Gin 190 Val1 Asp Al a Al a Ile Al a Asp Arg Al a Asp 160 Arg Val Leu Lys His Pro Ala Glu Leu Ser 185 Al a GI u Ile 225 Thr Al a Ile Ala 195 Thr Arg Asp Gly Ala 275 Ala Leu Vai As n Al a Lys 245 Ile Met Le u Val1 230 Ala Val1 Asn Arg As n Asp Tyr Le u 265 Giu Glu Se r Gin 235 Asp Asp Ile Phe Val1 Val1 Ile Ile 270 Gly Le u Ile Phe 255 Glu <210> 447 <211> 538 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(538) <223> FRXA02618 <400> 447 cgaaaccaga aacacccagc ggctcctcgt cgaaaagcga atctttgaac tagaagccca gqcacqttgq ctcgaccgaa ttgaagcatt. ggagcagtaa atg aca aac acg cct ttc Ph e CgC Arg gaa Giu ct C Le u atc Ile acc Thr ct t Leu gt C Val1 gtt Val1 gtc Val1 ggt Gly cgt Arg gaa Giu tCC Ser gcc Ala gcC Ala gcc Ala CgC Arg ct t Le u 9c9 Aila atc Ile Gi y agc Ser cac His caa Gin Ctc Le u atg Met ct C Le u gcc Ala 75 atc Ile t CC Se r gtC Val1 30 t CC Ser cgc Arg Ctc Le u att Ile gcc Ala Ctg Leu tca Ser acc Thr gc Al a caa Gin Met 1 ttc Phe gca Ala gga Gly tct Ser aaa Lys aac Asn Thr gga Gly gt C ValI aaa Lys ggc Gly cgc Arq tac Tyr Asn gaa Giu aat As n tcc Se r cat His gca Ala aac Asn Thr 9gC Gly CCC Pro acc Thr gt g Val1 gct Al a ctg Le u 100 115 163 211 259 307 355 403 CCC acc ctc acc gtc gga gaa aac atc Pro Thr Leu Thr Val Gly Giu Asn Ile 105 110 ggc aaa acc qac cqc cag gca gta gca Gly Lys Thr Asp Arg Gin Ala Val Ala 120 125 ctc aag ggc tct acg acc gct ttt ccc Leu Lys Gly Ser Thr Thr Ala Phe Pro 135 140 (210> 448 <211> 146 <212> PRT <213> Corynebacterium giutamicum ggt ctg ccc cta gaa ctc gac Gly Leu Pro Leu Glu Leu Asp 115 atc gca ctc gcg gaa gtc ggc Ile Ala Leu Ala Giu Val Gly 130 gag aga tct ctg Glu Arg Ser Leu 145 <400> 448 Met Thr Asn Thr Pro Phe 1 Phe Gly Giu Ala Val Asn Gly Lys Ser Ser Giy His Lys Arg Ala Asn Tyr Asn Pro Leu Giu 115 Leu Ala Giu 130 Ser Leu 145 <210> 449 <211> 975 <212> DNA Gly Pro Thr Val1 Ala Leu 100 Leu Val 5 Pro Gly Leu Leti Giu ValI Asp Gly Pro His Leu As n Asp Arg Thr Lys Lys 135 Leu Val Val1 40 Val Gly Arg Leu Thr 120 Gly Gi u Ser Ala Al a Ala Arg Thr 105 Asp Ser Le u 10 Ala Ile Gly Ser His 90 Val1 Arg Thr Gin Le u Met Leu Ala 75 Ile Gly Gin Thr Ile As n Pro Gin Asp Val1 Asn Val1 125 Phe Cys Ser Giy Ala Asn Phe Gly Ile Glu Ala Le u Ser Thr Ala Gin Leu Al a Arg z2 13> <220> <221> <222> <223> <400> Corynebacterium giutamicum C DS (101)..(952) FRXA02 900 449 tatgtccttt ggctooggta ccctggcagg agtacctggg ctcjtttttct aaaatggcct gacgttttca agattgaatt taaggaaagc atcgtagttc atg agt aac cct Met Ser Asn Pro gcg agc aca cct Ala Ser Thr Pro gcc Ala aac aat tcg gac Asn Asn Ser Asp gat Asp 15 gtt gcg aag gag Val Ala Lys Giu aat tgg Asn Trp gac: tct tot Asp Ser Ser aat aac tcg Asn Asn Ser acg CCg aag act Thr Pro Lys Thr att gac tct tcc Ile Asp Ser Ser cag oct gtc Gin Pro Val otg tao aag Leu Tyr Lys act ggt gaa gcc Thr Giy Giu Ala got Aila gog ogo gca gtg Ala Arg Ala Val gcg tat Ala Tyr ggc cag ggt gat Gly Gin Gly Asp act gtc acc gog Thr Val Thr Ala gat cac gtc aac Asp His Val Asn gtg Val gag ttt gag aag Giu Phe Giu Lys aag ttc act gcc Lys Phe Thr Ala atg ggt cct tct Met Gly Pro Ser ggc Gly tcg ggt aag tco Ser Gly Lys Ser ttg atg cac tgc Leu Met His Cys atg Met got ggt ctg gat Ala Gly Leu Asp got gcg Ala Ala 100 act ggt ggt Thr Gly Gly gac aaa gag Asp Lys Glu 120 t cg Ser 105 gca ttc att ggt Ala Phe Ile Gly gat Asp 110 acg gat ctg tcg Thr Asp Leu Ser cgg ttg aag Arg Leu Lys 115 ttc att ttc Phe Ile Phe 451 499 atg acc tct ttg Met Thr Ser Leu cgt gat ogt ttg Arg Asp Arg Leu cag tog Gin Ser 135 ttc aac ttg gtt Phe Asn Leu Val cct Pro 140 act otg acg gcg Thr Leu Thr Ala gag aac att acg Giu Asn ile Thr ctg Leu 150 cot acc gat atc Pro Thr Asp Ile ggc cgc aag att Gly Arg Lys Ile ga t Asp 160 cag tcg tgg tto Gin Ser Trp Phe gag att acc tct Giu Ile Thr Ser otg ggt ctg act Leu Gly Leu Thr gag Glu 175 cgc ctt aag cac Arg Leu Lys His ogt oct Arg Pro 180 gca gag oto Ala Glu Leu ttg gtg tct Leu Val Ser 200 ggt ggt cag cag Gly Gly Gin Gin cgt gtg gcg tgt Arg Val Ala Cys got cgt gog Ala Arg Ala 195 aco ggt aao Thr Gly Asn ogt cog gag atc Arg Pro Glu Ile att Ile 205 tto ggc gao gag Phe Gly Asp Giu cca Pro 210 691 739 787 *ttg gat Leu Asp 215 tog aao tot tot Ser Asn Ser Ser gaa gtg otg gat Glu Val Leu Asp otg ogo aco goa Leu Arg Thr Ala gtt gat cag gat gat cag acc gtt gtg atc gtt acc cac gat gcc aag 835 Val Asp Gin Asp Asp Gin Thr Vai Val Ile Val Thr His Asp Ala Lys 230 235 240 245 qcg gcg tcc tat gca gat cgt gtc att ttc ttg gcg gac ggt cgt atc 883 Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu Ala Asp Gly Arg Ile 250 255 260 gtg aac cag ttg ttt gat ccc acc atc gag gaa atc ttg gcc acg atg 931 Val Asn Gin Leu Phe Asp Pro Thr Ile Giu Glu Ile Leu Ala Thr Met 265 270 275 aac qga att gag gat att gcc taatgaattc cggttccaca atg 975 Asn Gly Ile Glu Asp Ile Ala 280 (210> 450 <211> 284 (212> PRT <213> Corynebacterium giutamicum (400> 450 Met Ser Asn Pro Ala Ala Ser Thr Pro Ala Asn Asn Ser Asp Asp Val 1 5 10 Ala Lys Giu Asn Trp Asp Ser Ser Phe Thr Pro Lys Thr Asp Ile Asp 25 Ser Ser Gin Pro Val Asn Asn Ser Thr Gly Glu Ala Ala Ala Arg Ala 40 Val Asn Leu Tyr Lys Ala Tyr Gly Gin Gly Asp Thr Thr Val Thr Ala 55 Leu Asp His Val Asn Val Glu Phe Glu Lys Asn Lys Phe Thr Ala Ile 70 75 Met Gly Pro Ser Giy Ser Gly Lys Ser Thr Leu Met His Cys Met Ala 90 Gly Leu Asp Ala Ala Thr Gly Gly Ser Ala Phe Ile Gly Asp Thr Asp 100 105 110 Leu Ser Arg Leu Lys Asp Lys Giu Met Thr Ser Leu Arg Arg Asp Arg 115 120 125 Leu Gly Phe Ile Phe Gin Ser Phe Asn Leu Val Pro Thr Leu Thr Ala 130 135 140 Ser Giu Asn Ile Thr Leu Pro Thr Asp Ile Ala Gly Arg Lys Ile Asp 145 150 155 160 Gin Ser Trp Phe Asp Giu Ile Thr Ser Arg Leu Gly Leu Thr Glu Arg 165 170 175 Leu Ly's His Arg Pro Ala Giu Leu Ser Gly Gly Gin Gin Gin Arg Vai 180 185 190 Ala Cx's Ala Arg Ala Leu Val Ser Arg Pro Giu Ile Ile Phe Gly Asp 195 200 205 Glu Pro Thr Gly Asn Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp 210 215 220 Ile Leu Arg Thr Ala Val Asp Gin Asp Asp Gin Thr Val Val Ile Val 225 230 235 240 Thr His Asp Ala Lys Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu 245 250 255 Ala Asp Gly Arg Ile Val Asn Gin Leu Phe Asp Pro Thr Ile Giu Glu 260 265 270 Ile Leu Ala Thr Met Asn Gly Ile Glu Asp Ile Ala 275 280 <210> 451 <211> 1452 <212> DNA <213> Corynebacterium glutanicun <220> <221> CDS <222> (1452) <223> RXS03212 <400> 451 gcc tca ctt aac tgg tca gtc atc gtt cca gcc cta gtc att gtc cta 48 Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu 1 5 10 gcg aca gtg gtg tgg ggt atc gga ttc aaa qat agc ttt acc aac ttt 96 Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Asn Phe 25 qct agt tct gcg ttg tca gca gta gtt gac aat ctc ggc tgg gcc ttc 144 Ala Ser Ser Aia Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe 40 att ttg ttt ggc aca gtc ttt gta ttt ttt atc gtt gtt atc gcc gct 192 Ile Leu Phe Giy Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala 55 agt aaa ttc ggc acg att cgc tta ggc cgc att gat gaa gca cca gag 240 Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Giu Ala Pro Glu 70 75 ttt cgc acg gtg tca tgg att tcc atg atg ttt gct gca ggt atg ggt 288 Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly 90 att ggt ttg atg ttc tac gga acc aca gaa cct tta acc ttc tac cgc 336 Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg 100 105 110 aat ggt gta cct gqa cat gat gaa cac aat gtt ggc gtt gct atg tcc 384 Asn Gly Vai Pro Gly His Asp Giu His Asn Val Gly Val Ala Met Ser 115 120 125 acg aca Thr Thr 130 atg ttc cac tgg Met Phe His Trp acc Thr 135 ttg cat cca tgg Len His Pro Trp etc tac gca att Ile Tyr Ala Ile ggc cta gcc att Gly Leu Ala Ile tat tcg acc ttc Tyr Ser Thr Phe cga Arg 155 gtg ggc cgt aaa Val Gly Arg Lys 432 480 528 Ctt cta agc tct Leu Leu Ser Ser gca Ala 165 ttc gtg cca ctc Phe Val Pro Leu ggt gee aaa ggt Gly Glu Lys Gly gca gee Ale Gin 175 gga tgg ttg Gly Trp, Leu ttc ggc acg Phe Gly Thr 195 aag ctc etc gec Lys Len Ile Asp ctg gcg ett etc Len Ale Ile Ile gcc ecc gte Ale Thr Val 190 att ggt gca Ile Gly Ale 576 624 gca tgt tcc ctt Ale Cys Ser Leu ggc Gly 200 ctt ggt gcc ctg Leu Gly Ala Leu ggc ctg Gly Len 210 tcc gce gce eec Ser Ala Ala Asn att gae gat cce Ile Giu Asp Pro agc Ser 220 get tgg ecc atc Asp Trp Thr Ile gtt Val1 225 ggc ett gtt tct Gly Ile Vel Ser gtt Val 230 ttg acc ctg gca Leu Thr Leu Ale etc ttc tcc gct Ile Phe Ser Ala 672 720 768 tct ggt gtg ggc Ser Gly Val Gly gga etc cag tac Gly Ile Gin Tyr tcc aac gcc aac Ser Asn Ala Asn aty gtt Met Val 255 ctg gce gct Len Ala Ale tcg ett ttg Ser Ile Len 275 ctg Len 260 ctc gcg ett ttc Leu Ala Ile Phe ttc gtt gtc gga Phe Val Vai Gly cca acc gtg Pro Thr Val 270 ctg tcc eec Len Ser Asn eec ctg ctg cce Asn Len Leu Pro ggt Gly 280 tct att ggc eec Ser Ile Gly Asn ttc ttt Phe Phe 290 caa atg gca ggc Gin Met Ala Gly act gcc etg agt Thr Ala Met Ser gcc Aie 300 gac ggc aca gca Asp Gly Thr Ale ggt Gly 305 gag tgg cte ggt Gln Trp Len Gly agc Ser 310 tgg acc etc ttc Trp Thr Ile Phe tgg gce tgg tgg Trp Ale Trp, Trp etc Ile 320 912 960 1008 tct tgg tce cca Ser Trp Ser Pro gte gga atg ttc Vai Gly Met Phe gca cgt att tcc Ale Arg Ile Ser cgt ggc Arg Gly 335 cgc tcc etc Arg Ser Ile gtg tcc ecc Val Ser Thr 355 cgt Arg 340 gag ttc etc ctg Gin Phe Ile Len gtg ttg ctc gtc Val Len Len Val cce gce ggt Pro Ale Giy 350 ett gtc ttc Ile Val Phe 1056 1104 gte tgg ttc tcc Val Trp Phe Ser ett Ile 360 ttt ggt ggc act Phe Gly Gly Thr gcg Al a 365 gee cee eat ggg gee tcc ett tgg ggt get ggt gca gca gee gag cag 1152 Glu Gin Asn Gly Glu Ser Ile Trp Gly Asp Gly Ala Ala Glu Glu Gin 370 375 380 ctt ttt gga ttg ctt cat gca ctt cca ggt ggg caa atc atg ggc ate 1200 Leu Phe Gly Leu Leu His Ala Leu Pro Gly Gly Gin Ile Met Gly Ile 385 390 395 400 atc gcc atg att ttg ctg ggt act ttc ttc.att acc tct get gac tct 1248 Ile Ala Met Ile Leu Leu Gly Thr Phe Phe Ile Thr Ser Ala Asp Ser 405 410 415 get tcc acc gtc atg ggc acc atg agt cag cac ggc cag ctg gaa gcc 1296 Ala Ser Thr Val Met Gly Thr Met Ser Gin His Gly Gin Leu Glu Ala 420 425 430 aac aag tgg gtg aca gct gcc tgg ggt gtt get acc gca get att gga 1344 Asn Lys Trp Val Thr Ala Ala Trp Gly Val Ala Thr Ala Ala Ile Gly 435 440 445 cta acg cta ttg ctt tct ggt ggt gac aat gcc ttg age aac ttg caa 1392 Leu Thr Leu Leu Leu Ser Gly Gly Asp Asn Ala Leu Ser Asn Leu Gin 450 455 460 aac gtc acc atc gtg gct gca aca cca ttc ttg ttt gtg gtt att gga 1440 Asn Val Thr Ile Val Ala Ala Thr Pro Phe Leu Phe Val Val Ile Gly 465 470 475 480 ttg atg ttt gcg 1452 Leu Met Phe Ala <210> 452 <211> 484 <212> PRT <213> Corynebacterium glutamicum <400> 452 Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu 1 5 10 Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Asn Phe 25 Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe 40 Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala 55 Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala Pro Glu 70 75 Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly 90 Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg 100 105 110 Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser 115 120 125 Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr Ala Ile 130 135 140 Val Giy Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gin 145 150 155 160 Leu Leu Ser Ser Ala Phe Vai Pro Leu Ile Gly Giu Lys Gly Ala Giu 165 170 175 Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val 180 185 190 Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gin Ile Gly Aia 195 200 205 Gly Leu Ser Ala Ala Asn Ile Ile Giu Asp Pro Ser Asp Trp Thr Ile 210 215 220 Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile 225 230 235 240 Ser Gly Val Gly Lys Gly Ile Gin Tyr Leu Ser Asn Ala Asn Met Val 245 250 255 Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Gly Pro Thr Val 260 265 270 Ser Ilie Leu Asn Leu Leu Pro Gly Ser Ile Gly Asn Tyr Leu Ser Asn 275 280 285 Phe Phe Gin Met Ala Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Ala 290 295 300 Gly Giu Trp Leu Gly Ser Trp Thr Ile Phe Tyr Trp Ala Trp Trp Ile 305 310 315 320 Ser Trp Ser Pro Phe Val Giy Met Phe Leu Ala Arg Ile Ser Arg Gly 325 330 335 Arg Ser Ile Arg Giu Phe Ile Leu Gly Val Leu Leu Val Pro Ala Giy 340 345 350 Val Ser Thr Val Trp Phe Ser Ile Phe Gly Gly Thr Ala Ile Val Phe 355 360 365 Giu Gin Asn Gly Giu Ser Ile Trp Gly Asp Gly Ala Ala Giu Giu Gin 370 375 380 Leu Phe Gly Leu Leu His Ala Leu Pro Gly Gly Gin Ile Met Gly Ile 385 390 395 400 Ile Ala Met Ile Leu Leu Gly Thr Phe Phe Ile Thr Ser Ala Asp Ser 405 410 415 Ala Ser Thr Val Met Gly Thr Met Ser Gin His Gly Gin Leu Giu Ala 420 425 430 Asn Lys Trp Val Thr Ala Ala Trp Gly Val Ala Thr Ala Ala Ile Gly 435 440 445 Leu Thr Leu Leu Leu Ser Gly Gly Asp Asn Ala Leu 450 455 460 Asn Val Thr Ile Val Ala Ala Thr Pro Phe Leu Phe 465 470 475 Ser Asn Leu Gin Val Vai Ile Leu Met Phe Ala <210> 453 <211> 945 <212> DNA <213> Corynebacterium glutamicun <220> <221> <222> <223> C DS (945) FRXA01591 <400> 453 gcc Al a 1 tca ctt aac Ser Leu Asn tca gtc atc gtt Ser Val Ile Val cca Pro 10 gcc cta gtc att Ala Leu Val Ile qtc cta Val Leu gcg aca gtg Ala Thr Val gct agt tct Ala Ser Ser gtg Val tgg ggt atc qga Trp Gly Ile Gly aaa gat agc ttt Lys Asp Ser Phe acc acc ttt Thr Thr Phe tgg gcc ttc Trp Ala Phe gcq ttg tca gca Ala Leu Ser Ala gt a Val1 40 gtt gac aat ctc Val'Asp Asn Leu 9gC Gly att ttg Ile Leu ttt ggc aca gtc Phe Gly Thr Val gta ttt ttt atc Val Phe Phe Ile gtt atc gcc gct Val Ile Ala Ala agt aaa ttc ggc acg att cgc tta ggc cgc att Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile 70 gat gaa gca cca Asp Glu Ala Pro 240 ttt cgc acq gtg Phe Arg Thr Val tgg att tcc atg Trp Ile Ser Met atg Met ttt gct gca ggt Phe Ala Ala Giy atg ggt Met Gly att ggt ttg Ile Gly Leu aat ggt gta Asn Gly Val 115 atg Met 100 ttc taC gga acc Phe Tyr Gly Thr gaa cct tta acc Glu Pro Leu Thr ttc tac cgc Phe Tyr Arg 110 gct atg tcc Ala Met Ser cct qga cat gat Pro Gly His Asp cac aat gtt ggc His Asn Val Gly acg aca Thr Thr 130 atg ttc cac tqq Met Phe His Trp acc Thr 135 ttg cat cca tgg Leu His Pro Trp qct Ala 140 atc tac gca att Ile Tyr Ala Ile gt g Val1 145 ggc cta gcc att Gly Leu Ala Ile gcc Ala 150 tat tcq acc ttc Tyr Ser Thr Phe gtq ggc cqt aaa Val Gly Arg Lys Ctt cta agc tct gca ttcgt gtg Leu Leu Ser Ser Phe Val cca ctc att Pro Leu Ile 170 gqt gaa aaa ggt Gly Giu Lys Gly gca gaa Ala Giu 175 gga tgg ttg Gly Trp Leu ttc ggc acg Phe Gly Thr 195 aag ctc atc gac Lys Leu Ile Asp ctg gcg att atc Leu Ala Ile Ile gCC acc gta Ala Thr Val 190 att ggt gca Ile Gly Ala gca tgt tcc ctt Ala Cys Ser Leu ggC Gly 200 ctt ggt gcc ctg Leu Gly Ala Leu cag Gin 205 ggc ctg Gly Leu 210 tcc gca gca aac Ser Ala Ala Asn att gaa gat cca Ile Glu Asp Pro gat tqg acc atc Asp Trp Thr Ile gjt t Val1 225 ggc att gtt tct Gly Ile Val Ser gtt Val1 230 ttg acc ctg gca Leu Thr Leu Ala ttt Phe 235 atc ttc tcc gct Ile Phe Ser Ala att Ile 240 tct ggt gtg ggc Ser Gly Val Gly gqa atc cag tac Gly Ile Gin Tyr ctc Leu 250 tco aac gcc aac Ser Asn Ala Asn atg gtt Met Val 255 Ctg gca got Leu Ala Ala tcg att ttg Ser Ile Leu 275 Ct 9 Leu 260 ctc gcg att ttc Leu Ala Ile Phe ttc gtt gtc gga Phe Val Val Gly cca acc gtg Pro Thr Vai 270 ctg tcc aac Leu Ser Asn aac ctg ctg cca Asn Leu Leu Pro ggt Gly 280 tct att gtg aac Ser Ile Val Asn tac T yr 285 ttc ttt Phe Phe 290 caa atg 9ta ggc Gin Met Val Gly CgC Arg 295 act gcc at9 agt Thr Ala Met Ser gac 990 aca cca Asp Gly Thr Pro ggt Gly 305 gag tgg ctt ggt Glu Trp Leu Gly 990 Gly 310 tgc acc atc ttc Cys Thr Ile Phe <210> 454 <211> 315 <212> PRT <213> Corynebacterium giutamicum <400> 454 Ala Ser Leu Asn Trp Ser Val Ile Val Pro 1 5 10 Ala Leu Val Ile Val Leu Ala Thr Vai Val Trp Gly Ile Gly Phe 25 Ala Ser Ser Ala Leu Ser Ala Val Val Lys Asp Ser Phe Thr Thr Phe Trp Ala Phe Asp Asn Leu Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val 55 Ser Lys Phe Giy Thr Ile Arg Leu Gly Arg Ile Asp 70 Val Ile Ala Ala Glu Ala Pro Phie Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly 90 Ilie Gly Leu Met Phe Tyr Gly Thr Thr Giu Pro Leu Thr Phe Tyr Arg 100 105 110 Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser 115 120 125 Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr Ala Ile 130 135 140 Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gin 145 150 155 160 Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly Ala Giu 165 170 175 Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val 180 185 190 Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gin Ile Gly Ala 195 200 205 Gly Leu Ser Ala Ala Asn Ile Ile Giu Asp Pro Ser Asp Trp Thr Ile 210 215 220 Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile 225 230 235 240 Ser Gly Val Gly Lys Gly Ile Gin Tyr Leu Ser Asn Ala Asn Met Val 245 250 255 Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Giy Pro Thr Val 260 265 270 Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Val Asn Tyr Leu Ser Asn 275 280 285 Phe Phe Gin Met Val Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Pro 290 295 300 Gly Giu Trp Leu Gly Gly Cys Thr Ile Phe Tyr 305 310 315 <210> 455 <211> 292 <212> DNA <213> Corynebacterium giutamicum <220> <221>' CDS <222> (292) <223> RXN00201 <400> 455 acgtcgcgga. cttcaagtag tcggcgatga aaaagtccgt ttactaaacc ccgatctgtg ttacgccatc gcgcggctcg ggcacaccga tacctgqgca gtcj gca gat tgc gqa 115 Val Ala Asp Cys Gly tta ccc atc cca Leu Pro Ile Pro ga a Giu cac gta gag atc His Val Glu Ile gat ttg gca ctc Asp Leu Ala Leu gtg ttt Val Phe ggg atc ccc Gly Ile Pro gtt gtg gaa Val Val Giu ttt gaa caa gta Phe Giu Gin Val aat qct ctc aag Asn Aia Leu Lys ccg gaa gta Pro Giu Val cgt atc cgc Arg Ile Arg 211 259 ggc gcg gtg att Gly Ala Val Ile gaa qgg gca ccc Glu Giy Ala Pro gaa aty Glu Met gtg gat acg gat Vai Asp Thr Asp gaa gta tgt gcg Giu Val Cys Ala <210> 456 <211> 64 <212> PRT <213> Corynebacterium giutamicum (400> 456 Val Ala Asp Cys Gly 1 5 Leu Pro Ile Pro Glu His Val Gu Ile Ile Asp 10 is1 Leu Ala Leu Leu Lys Pro Pro Gin Arg Va 1 Phe Gly Ile Pro Phe Glu Gin Val Leu Asn Ala Giu Gly Ala Glu Val Val Val Gly Ala Val IleAl a Ile Arg Giu Val Asp Thr Asp Giu Val Cys Ala <210> <211> <212> <213> <220> <221> <222> <223> 457 286 DNA Corynebacterium giutamicun C DS (101)..(286) FRXA00201 <400> 457 acqtcgcgga cttcaagtag tcggcgatga aaaagtccgt ttactaaacc ccgatctgtg ttacgccatc qcgcggctcg ggcacaccga tacctgggca gtg gca gat tgc gga Val. Ala Asp Cys Gly 1~ tta ccc atc cca gaa cac gta gag atc atc gat ttg gca ctc gtg ttt 163 Leu Pro Ile Pro Ciu His Vai Giu Ile Ile Asp Leu Ala Lou Val. Phe ggg atc ccc Gly Ile Pro gtt gtg gaa Val Val. Glu ttt gaa caa gta Phe Glu Gin Val. ctg Leu aat gct ctc aag Asn Ala Leu Lys ccg gaa gta Pro Giu Val cgt atc cgc Arg Ile Arg 211 259 ggc gcg gtq att Gly Ala Val Ile gaa gqq gca ccc Giu Gly Ala Pro gaa atg gtg gat acg gat Glu Met Val Asp Thr Asp gtg gaa gtt Val Giu Val <210> 458 <211> 62 <212> PRT <213> Corynebacterium glutamicum <400> 458 Val Ala Asp Cys Gly 1 5 Leu Pro Ile Pro Giu 10 His Val Giu Ile Ile Asp Leu Ala Leu Leu Lys Pro Pro Gin Arg Phe Gly Ile Pro Phe Giu Gin Val Leu Asn Ala Giu Gly Ala Glu Vai Val Val Giu 40 Gly Ala Val Ile Al a Ile Arg Giu Val Asp Thr Asp Val Giu Val <210> 459 <211> 849 <212> DNA <213> Corynebacterium glutamicum <220> <221:> <222> <223> C DS (101)..(826) RXA01221 <400> 459 tccaqggtgc gatcctggtt ctcgtgatcg tgttgctgcc gggcggaatt qcttcaatta aactttccgc gctcaaaaat aaggccagga aggccacctc acc aac ctc aaa gtc gct ttc qgg tcg ttc atc Thr Asn Leu Lys Val Ala Phe Gly Ser Phe Ile 15 atg agc ctt aaa atc Met Ser Leu Lys Ile 1 gcc gtg aat gag att Ala Val Asn Glu Ile ctc atc ggt gcc aac Leu Ile Gly Ala Asn agt ttt cag gtg ctg ccc ggt cac Ser Phe Gin Val Leu Pro Gly His gtc cac ttc Val His Phe 30 ggt gca ggt aaa acc acc tqc att gac gcg atc agc gga ttg gcg ccg 259 Gly Ala Gly Lys Thr Thr Cys Ile Asp Ala Ile Ser Gly Leu Ala Pro ggg cag Gly Gin gga tca gtg cag Gly Ser Val Gin gat ggc act gag Asp Gly Thr Gin ctg gga acc cct Len Gly Thr Pro gtg Val1 cac cgc att gct His Arg Ile Ala cgg Arg 75 atg ggt gtg ggq Met Gly Val Gly cga Arg acg ttt caq acc Thr Phe Gin Thr agc gtg ttt gaa Ser Val Phe Giu tig tct gtg ttg Leu Ser Val Leu aat ctg gat att. Asn Leu Asp Ile gcg tgc Ala Cys 100 ggg att cat Gly Ile His gat ccc cga Asp Pro Arg 120 cgt Arg 105 ccg ttg cgg gcg Pro Leu Arg Ala ct t Leu 110 ctc ggg gtg cgt Len Gly Val Arg cat cqg att His Arg Ile 115 gct gat ctg Ala Asp Len att. gaa cac gcc Ile Glu His Ala gag gtc acg ggt Giu Val Thr Gly gtg aat Val Asn 135 gct cag gcg gga Ala Gin Ala Gly acc Th r 140 ttg tcg cat ggg Len Ser His Gly cag Gin 145 aaa cag tgg ctg Lys Gin Trp Len att gca atg ttg Ile Ala Met Leu gtg cag gat gcg Val Gin Asp Ala gtg ctc atg ctg Val Len Met Leu gag ccg gtg gcg Giu Pro Val Ala atg agt gag gag Met Ser Giu Giu gag Giu 175 cgt gtc gca acg Arg Val Ala Thr ggt gag Gly Glu 180 ctt ttg cag Leu Len Gin gat atg gag Asp Met Giu 200 agg Arg 185 gtt gcg cgg gga Val Ala Arg Gly cg Arg 190 gig gtg ttg gtg Val Val Len Val gtg gag cac Val Gin His 195 gig atg aat Val Met Asn ttc atg cgt cgt Phe Met Arg Arg gcc act cgc gtc Ala Thr Arg Val cgc ggc Arg Gly 215 acg atc ttg tgt Thr Ile Len Cys gag Gin 220 ggg tcg gtc gat Gly Ser Val Asp gag Giu 225 att cag gcg aat Ile Gin Ala Asn gat gtg cag tcc Asp Val Gin Ser tat tta ggt acg Tyr Leu Gly Thr gca ggg aag Ala Gly Lys 240 tgagttagtc 836 atgttggaaa tca <z210> 460 <211> 242 <212> PRT <213> Corynebacterinm giutamicnm <400> 460 Met Ser Len Lys Ile Thr Asn Len Lys Val Ala Phe Gly Ser Phe Ile Al a Le u Ser Ile Thr Leu Val1 Gly Gin 145 Val1 Val1 Leu Val1 Giu 225 Gly Val1 Ile Gly Le u Phe Asp Arg Le u 130 Lys Le u Al a Val1 Thr 210 Ile Lys Asn Giu 1 Gly Ala A Leu Ala P Gly Thr P Gin Thr A Ile Ala C 100 His Arg I 115 Ala Asp L Gin Trp Li Met Leu A~ I Thr Gly G. 180 Val Giu h. 195 Val Met A: Gin Ala A: le Ser Phe Gin Val Leu Pro Gly His Val His Phe 25 Sn ro ro la ys le eu sp lu is Sn sn Gly Gly Val1 70 Ser Gly Asp Val1 Glu 150 Giu Leu Asp Arg Pro 230 Ala Gin 55 His Val1 Ile Pro As n 135 Ile Pro Leu Met Gly 215 Asp Gly 40 Gly Arg Phe His Arg 120 Ala Al a Val1 Gin Glu 200 Thr Val1 Thr Gin Arg 75 Leu Leu His Gly Leu 155 Met Ala Arg Cys Ile 235 Cys Leu Met Ser Arg Ala Thr 140 Val1 Ser Arg Arg Glu 220 Tyr Ile Asp Gly Val1 Ala Le u 125 Leu Gin Glu Gly Phe 205 Gly Le u Asp Giy Val1 Leu Leu 110 Giu Ser Asp Glu Arg 190 Ala Ser Gly Ile Giu Arg As n Gly Thr Gly Gin 160 Arg Val Arg Asp Al a 240 <210> 461 <211> 822 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101) (799) <223>' RXA01222 <400> 461 aatcgcggca cgatcttgtg tgaggggtcg gtcgatgaga ttcaggcgaa tccggatgtg cagtccattt atttagqtac kgcaggjgaag tgagttagtc atg ttg qaa atc act 115 Met Leu Glu Ile Thr aat ttg tqt gca Asn Leo Cys Ala tat ggc cgo acg cag gta ctt cat tct Tyr Gly Arg Thr Gin Val Leu His Ser Ott tca Leu Ser atc tcc acg Ile Ser Thr gct ggt aaa Ala Gly Lys agc aac ggo atc Ser Asn Gly Ile tog ato ctc ggc Ser Ile Leu Gly cac aat ggc His Asn Gly att aag cog Ile Lys Pro tcc acc ttg ctg cga aco gcg gtg ggg Ser Thr Leu Leu Arg Thr Ala Val Gly act tcc Thr Ser gga gag gtc aaa Gly Glu Val Lys ttc ggo cag gat Phe Gly Gin Asp aco tog ttg too Thr Ser Leu Ser 259 307 355 403 oat gag oga gta His Giu Arg Val aag Lys ogo gga atg got Arg Gly Met Ala tat Tyr gtg cog oag ggo Val Pro Gin Gly cag tot ttt aog Gin Ser Phe Thr ott agt tgc atg Leu Ser Cys Met aat ttg cag gtg Asn Leo Gin Val gta gog Val Ala 100 gat ctg cag Asp Leu Gin cgc ttt CCg Arg Phe Pro 120 ogt gtg ggo aag Arg Val Gly Lys ogo ato gcg gag Arg Ile Ala Glu gog ott gat Ala Leu Asp 115 ggc Ctg ttq Gly Leu Leu gcg ctg acc cag Ala Leo Thr Gin ctg gac cgc caa Leo Asp Arg Gin gCC Al a 130 tog qgt Ser Gly 135 ggt cag ogt cag Gly Gin Arg Gin cag Gin 140 ott gco ato goo Leo Ala Ile Ala gcg otg ato aog Ala Leo Ile Thr oca aag Ott ttg Pro Lys Leu Leo oto gao gaa 000 Leo Asp Glu Pro gag ggt att cag Glu Gly Ile Gin tog gtg gtt got Ser Val Val Ala gaa Glu 170 att cag oag acc Ile Gin Gin Thr atc Ile 175 ato gat ttg got Ile Asp Leo Ala aag gao Lys Asp 180 ggc atg ago Gly Met Ser got goa aca Ala Ala Thr 200 gto otg gtg gag Val Leo Val Glu aac att ggt ttt Asn Ile Gly Phe goa ttg gat Ala Leo Asp 195 gtg gaa tog Val Glu Ser 691 739 ago tao goo att Ser Tyr Ala Ile gog ogt ggt cag Ala Arg Gly Gin gga oaa ggc got gaa aco Gly Gin Gly Ala Glu Thr 215 ac Thr 220 gca gag aag cag Ala Gbu Lys Gin aot Thr 225 aaa gtg ogg gaa Lys Val Arg Glu tot ota goa atc Ser Leo Ala Ile tagoggotgt ggatagcgtt ttg 230 <210> 462 <211> 233 <212> PRT <213> Corynebacterium glutamicun <400> 462 Met Leu Glu 1 Leu His Ser Leu Gly His Gly Leu Ile Val. Thr Ser Val Pro Gin Leu Gin Val Ala Giu Ala 115 Gin Ala Gly 130 Arg Ala Leu 145 Giu Gly Ile Asp Leu Ala Gly Phe Ala 195 Gin Val Val 210 Thr Lys Val 225 Ile Le u Asn Lys Le u Gi y Val1 100 Le u Le u Ile Gin Lys 180 Le u Giu Arg Thr Asn Leu Cys Ala 5 Ser Gly Pro Ser Gin Ala Asp Leu Thr Pro 165 Asp Asp Ser Glu Ile Ala Thr Thr Gin Asp Arg Ser Ala 150 Ser Gly Ala Gly Ser 230 Ser Gly Ser 55 His Ser Leu Ph e Gly 135 Pro Val1 Met Ala Gin 215 Leu Thr Lys Gly Glu Phe Gin Pro 120 Gi y Lys ValI Ser Thr 200 Gi y Al a Gly 10 Se r Thr Val1 Val1 Gin 90 Arg Le u Arg Leu Giu 170 Val1 Tyr Giu Tyr Gly Arg Thr Gin Val Gly Leu Leu Arg Ser Gly Gin Gin 140 Leu Gin Val1 Ile Thr 220 Leu Thr Gly Met Met Al a 110 Leu Al a Glu Thr Gin 190 Ala Glu Se r Ala Gin Ala Glu Arg Asp Ile Pro I le 175 As n Arg Lys <210> 463 <211> 1005 <212> DNA <213> Corynebacterium qiutarnicum <220> <221> CDS <222> (101)..(982) <223> RXA01219 caccatttgg gaaaecgatt ccccaqttga tccggaccca ggccaagaec accgctgcga cttcctaaga gataaaaatc tacttgtctt cctatgactg atg Met 1 gac att tta Asp Ile Leu aat cag ctc qta Asn Gin Leu Val gCC Ala ggg ctt tca gtt Gly Leu Ser Val gga Gly 15 teg gte ctt cta Ser Val Leu Leu ttg gtc Leu Val gca gtg gga Ala Val Gly gcg cac gga Ala His Gly tca ctg aec ttt Ser Lau Thr Phe cag atg ggc gtt Gin Met Gly Vai att aat atg Ile Asn Met tat gtg gtg Tyr Val Val gag ttc atc atg Glu Phe Ile Met gtc Val1 ggc gca tac ac Gly Ala Tyr Thr cag etg Gin Leu gtc gte ggt tet Val Val Gly Ser ggt tta tec eta Gly Leu Ser Leu ctg Leu atc age att ccg Ile Ser Ile Pro ctg Le u gcc ttt att atc Ala Phe Ile Ile ggg ctt ttc gga Gly Leu Phe Gly etc ctc gaa caa Leu Leu Giu Gin ttc Phe 307 355 403 ctg ctg aag tat Leu Leu Lys Tyr ctt Leu tat eac agg cca Tyr His Arq Pro eta Leu 95 qac acg ctg ctg Asp Thr Leu Leu gec aca Ala Thr 100 ttc ggt gic Phe Gly Vai get ccc gca Ala Pro Ala 120 ttg ate ett cag Leu Ile Leu Gin ctg gee cga aac Leu Ala Arg Asn att ttc gga Ile Phe Gly 115 gga aac gte Gly Asn Val 451 499 gtq gat gte agg Val Asp Val Arg gea Ala 125 ceg gaa ttt etc Pro Giu Phe Leu gaa gtt Giu Val 135 eta ggc gte ttg Leu Gly Val Leu ecg ace geg ega Pro Thr Ala Arg eta Leu 145 ttc atc ctg geg Phe Ile Leu Ala ctg Leu 150 gee ate gca tea Ala Ile Ala Ser act gea eta get Thr Ala Leu Ala tte eta aat ege Phe Leu Asn Arg 547 595 643 gec tgg ggc ega Ala Trp Gly Arg ege Arg 170 ate ege gee gtg Ile Arg Ala Val etg aae ege gac Leu Asn Arg Asp etc geg Leu Ala 180 gaa ace gea Giu Thr Ala att gat ace ega Ile Asp Thr Arg act gac ega atg Thr Asp Arg Met aeg ttc ttt Thr Phe Phe 195 gtg ggc tee ggt ctt gee gga ate gee gqg gta get ate aca ttg att Val Gly Ser Gly Leu Ala Gly Ile Ala Gly Val Ala Ile Thr Leu Ile 739 200 205 210 ggc gcg acc ggc ccc acc atc ggt cag aac tao atc gtg gat goc ttc 787 Gly Ala Thr Gly Pro Thr Ile Gly Gin Asn Tyr Ile Val Asp Aia Phe 215 220 225 ott git gtt gcc goc ggt ggc aic: ggc cgg gig aag ggc gct gig atc 835 Leu Val Val Ala Ala Giy Gly Ile Gly Arg Val Lys Gly Ala Val Ile 230 235 240 245 atg gct ttc gig cig gga att act caa gca tic gtg gaa tat acg aca 883 Met Ala Phe Val Leu Gly Ile Thr Gln Ala Phe Val Glu Tyr Thr Thr 250 255 260 ggi gcg agc atc gcg aag ttc aic qia ctc aic gci git git gcc tic 931 Gly Ala Ser Ile Ala Lys Phe Ile Val Leu Ile Ala Val Val Ala Phe 265 270 275 cig cag iii agg cci caa gga cic tic caa aoc caa act agg ago cic 979 Leu Gin Phe Arg Pro Gin Giy Leu Phe Gin Thr Gin Thr Arg Ser Leu 280 285 290 gia tgagcactca actcaagctg aag 1005 Val <210> 464 <211> 294 <212> PRT <213> Corynebacterium giutarnicum <400> 464 Met Asp Ile Leu Leu Asn Gin Leu Val Ala Gly Leu Ser Val Gly Ser 1 5 10 Val Leu Leu Leu Vai Ala Vai Giy Leu Ser Leu Thr Phe Gly Gin Met 25 Gly Val Ile Asn Met Ala His Gly Glu Phe Ile Met Val Gly Ala Tyr 40 Thr Ala Tyr Val Val Gin Leu Val Val Gly Ser Ala Gly Leu Ser Leu 55 Leu Ilie Ser Ile Pro Leu Ala Phe Ile Ile Gly Gly Leu Phe Gly Val 70 75 Leu Leu Giu Gin Phe Leu Leu Lys Tyr Leu Tyr His Arg Pro Leu Asp 90 Thr Leu Leu Ala Thr Phe Gly Val Gly Leu Ile Leu Gin Gin Leu Ala 100 105 110 Arg Asn Ile Phe Giy Ala Pro Aia Val Asp Val Arg Ala Pro Giu Phe 115 120 125 Leu Arg Gly Asn Val Glu Val Leu Gly Val Leu Val Pro Thr Ala Arg 130 135 140 Leu Phe Ile Leu Ala Leu Ala Ile Ala Ser Val Thr Ala Leu Ala Val 145 150 Phe Leu Asn Arg Thr Ala Trp Gly 165 Asn Arg Asp Leu Ala Glu Thr Ala 180 Arg Met Thr Phe Phe Val Gly SerC 195 200 Ala Ile Thr Leu Ile Gly Ala Thr 210 215 Ile Val Asp Ala Phe Leu Val Val 1 225 230 Lys Gly Ala Val Ile Met Ala Phe 245 Val Giu Tyr Thr Thr Gly Ala SerI 2602 Ala Val Val Ala Phe Leu Gin Phe 1 275 280 Gin Thr Arg Ser Leu Val 290 <210> 465 <211> 1200 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (10i)..(1177) <223> RXA01220 <400> 465 caggtgcgag catcgcgaag ttcatcgtac ggcctcaagg actcttccaa acccaaacta k.rg ;iy 185 31y l a al1 le .rg 155 Ile Asp Ala Thr Gly 235 Gly Lys Gin Arg Thr Gl y Ile 220 Gi y Ile Phe Gi y Al a Arg Ile 205 Gi y Ile Thr Ile La u 285 Val1 175 Thr Gly Asn Arg Ala 255 Leu Gin 160 Leu Asp Val1 Tyr ValI 240 Phe Ile Thr tcatcgctgt ggagcctcgt aag Lys gta ValI gct Al a acq Thr ctg Le u aat Asn gcg Al a ttg La u aag Lys ccc Pro ttg Leu tcg Ser aag Lys cgc Arg goc Ala gtg Val1 aaa Lys 9cg Al a 30 ct C Leu tat Tyr tgttgccttc ctgcagttta atg agc act caa ctc Met Ser Thr Gin Leu 1 ccg aaa ctt ago gtc Pro Lys Leu Ser Val ggc ctg gcC gcg ctc Gly Leu Ala Ala Leu tcc aca ttc cag ctg Ser Thr Phe Gin Leu qtc gca gtc ggc atc Val Ala Val Gly Ile 115 163 211 259 307 ctg gcg tgg ggc Leu Ala Trp Gly ggc ggc atg ctc Gly G].y Met Leu acg Thr ctg ggg caa ggc Leu Gly Gin Gly ttc ttt gga atc Phe Phe Gly Ile ggc Gi y gcg tac atc atg Ala Tyr Ile Met atg cac atg ctg Met His Met Leu tac agc Tyr Ser 100 gat tcg cag Asp Ser Gin gcc aac ccg Ala Asn Pro 120 ttt ggg acc aca gtt ccg caa tgg tgg Phe Gly Thr Thr Val Pro Gin Trp Trp tcc att. ttt Ser Ile Phe 115 ccc qgc atc Pro Gly Ile gca gtc gca ctc atc gca gtt. gtg gcg Ala Val Ala Leu Ile Ala Val Val Ala ctt Leu 130 qtg gct Val Ala 135 ttt gtg ctc ggc Phe Val Leu Gly tcc att ttc aaa Ser Ile Phe Lys cgc atc aaa ggc Arg Ile Lys Gly tac ttt gcc atc Tyr Phe Ala Ile aac caa gcg ctc Asn Gin Ala Leu gcc Ala 160 gca gct gtt gtg Ala Ala Val Val ttg ctg gtc gga Leu Leu Val Gly caa Gin 170 caa gat tcc ctt Gin Asp Ser Leu ggt tcc aat ggt Gly Ser Asn Gly ctt tcc Leu Ser 180 gga ttt cga Gly Phe Arg atc atg ttt Ile Met Phe 200 ttc atg ggt ttt Phe Met Gly Phe gtc tac gac ccc Val Tyr Asp Pro atc aac cgc Ile Asn Arg 195 ttg gtg gct Leu Val Ala 691 739 tac ttc acc gca Tyr Phe Thr Ala gga gtt ctc ttg Gly Val Leu Leu atc tca Ile Ser 215 tat tgg ctc atg Tyr Trp Leu Met cgc Arg 220 agc cgc tat gga Ser Arg Tyr Gly gaa Giu 225 ctg ctc gtg gcc Leu Leu Val Ala aga gat gca qaa Arg Asp Ala Giu cgc gtc cga ttc Arg Val Arg Phe ct c Le u 240 gga tat gat ccc Gly Tyr Asp Pro 787 835 883 ttq atc aaa acc Leu Ile Lys Thr gcc Ala 250 gca tat gtc att Ala Tyr Val Ile gcg atg att. gcc Ala Met Ile Ala gga atc Gly Ile 260 gcc gga gcg Ala Gly Ala atc qgc gtg Ile Gly Val 280 ttc qtg ccg atc Phe Val Pro Ile ggc atc att tca Gly Ile Ile Ser ccc gca gaa Pro Ala Glu 275 gcc gct. ggt Ala Ala Gly gtg cca tca atc Val Pro Ser Ile ttc gtg atc gcc Phe Val Ile Ala qgc agg Gly Arg 295 gca tcc cta ttc Ala Ser Leu Phe ggt Gly 300 ccc gta gtt ggc Pro Val Val Gly gcg Ala 305 ctg gtg ctg ggc Leu Val Leu Gly 1027 tgg gtg gaa tcc aca ctt gct caa act ttc ccc agc atg tgg tcc tat 1075 Trp Val Giu Ser Thr Leu Ala Gin Thr Phe Pro Ser Met Trp Ser Tyr 310 315 320 325 ttc cag ggt gcg atc ctg gtt ctc gtg atc gtg ttg ctq ccg ggc gga 1123 Phe Gin Giy Ala Ile Leu Val Leu Val Ile Val Leu Leu Pro Gly Giy 330 335 340 att gct tca att aaa ctt tcc gcg ctc aaa aat aag gcc agg aag gcc 1171 Ile Ala Ser Ile Lys Leu Ser Ala Leu Lys Asn Lys Ala Arg Lys Ala 345 350 355 acc tca tgagccttaa aatcaccaac ctc 1200 Thr Ser <210> 466 <211> 359 <212> PRT <213> Corynebacterium qiutamicum <400> 466 Met Ser Thr Gin Leu Lys Leu Lys Lys Pro Ala Lys Lys Lys Thr Thr 1 5 10 Pro Lys Leu Ser Vai Val Asn Ala Pro Thr Leu Arg Thr Ala Ala Leu 25 Gly Leu Ala Ala Leu Ala Ala Val Leu Leu Cys Ala Pro Leu Phe Leu 40 Ser Thr Phe Gin Leu Thr Leu Met Ser Arg Leu Val Cys Tyr Ala Ile 55 Val Ala Val Gly Ile Giy Leu Ala Trp Gly Arg Gly Gly Met Leu Thr 70 75 Leu Gly Gin Gly Val Phe Phe Gly Ile Gly Ala Tyr Ile Met Ala Met 90 His Met Leu Tyr Ser Asp Ser Gin Ile Phe Gly Thr Thr Val Pro Gin 100 105 110 Trp Trp Ser Ile Phe Ala Asn Pro Ala Val Ala Leu Ile Ala Val Val 115 120 125 Ala Leu Pro Gly Ile Val Ala Phe Val Leu Gly Phe Ser Ile Phe Lys 130 135 140 Arg Arg Ile Lys Gly Ala Tyr Phe Ala Ile Val Asn Gin Ala Leu Ala 145 150 155 160 Ala Ala Val Val Val Leu Leu Val Gly Gin Gin Asp Ser Leu Gly Gly 165 170 175 Ser Asn Gly Leu Ser Gly Phe Arg Ser Phe Met Gly Phe Ala Val Tyr 180 185 190 Asp Pro Ile Asn Arg Ile Met Phe Tyr Phe Thr Ala Val Gly Val Leu Le u Glu 225 Gly Met Ile Al a Al a 305 Ser Le u Lys Ala 210 Leu Tyr I le Ser Val1 290 Leu Met Leu Ala 195 Leu Le u Asp Al a Pro 275 Ala Val1 Trp Pro Arg 355 Val1 Val1 Pro Gly 260 Ala Al a Leu Ser Gly 340 Lys Al a Al a Ala 245 Ile Glu Gly Gly Tyr 325 Gl y Ala Ile Thr 230 Le u Ala Ile Gi y Trp 310 Phe Ile Th r Ser 215 Arg Ile Gi y Gly Arg 295 Val1 Gln Al a Ser Trp Al a Thr Leu 265 Val1 Ser Ser Al a Ile 345 Met Glu 235 Ala Val1 Ser Phe Leu 315 Leu Leu Arg Arg I le Val1 270 Phe Val1 Thr Val1 Leu 350 Tyr Ph e Ala 255 Gly Val1 Val1 Phe Ile 335 Lys <210> 467 <211> 876 <212> DNA <213> Corynebacterium giutarnicum <220> <221> CDS <222> (101)..(853) <223> RXA00091 <400> 467 tcatgaaeea cqtgttccgc gcacaaqgcq tcgtqtccat gtaccgtctt cctcatcgtc atcetcagaa agggcagact aat gtc cgc aag gaa tac tcc agc gao gtt gc Asn Val Arg Lys Glu Tyr Ser Ser Asp Val Ala 15 Ott gag atc cca gec ggc ggc atc acc gcg ttg Leu Glu Ile Pro Ala Gly Gly Ile Thr Ala Leu 30 gca ggc aag tca aca ctg ctc acc atg ate gqt Ala Gly Lys Ser Thr Leu Leu Thr Met Ile Gly 45 cattattqag atggtcggcg gtg att acg tta act 115 Val Ile Thr Leu Thr 1 atc gqc ccc gtc aac 163 Ile Gly Pro Val Asn gtc ggc cca aac ggt 211 Val Gly Pro Asn Gly cga ctc etc ggc atc 259 Arg Leu Leu Gly Ile gat gaa Asp Giu ggc aac atc 800 Gly Asn Ile Thr gcc tcc tao gat Ala Ser Tyr Asp gt c Val1 acc tca acc gca Thr Ser Thr Ala aaa gat ctg gc Lys Asp Leu Ala ato atc tcc atc Ile Ile Ser Ile ogc cag gaa aac Arg Gin Giu Asn cac His 355 403 ttt gtt acc aag Phe Val Thr Lys acc gtq ogo cag Thr Vai Arg Gin ct c Leu gta ggt ttc gga Val Gly Phe Gly cgc ttc Arg Phe 100 cca tat ago Pro Tyr Ser cgo tac ato Arg Tyr Ile 120 aag Lys 105 ggo cgg otg aog Gly Arg Leu Thr gaa gac gag gga Giu Asp Giu Gly atc atc too Ile Ile Ser 115 cgc tao oto Arg Tyr Leu 451 499 qac ttc ttc aat Asp Phe Phe Asn oto Leu 125 800 gaa ctc gaa Thr Giu Leu Glu gao cag Asp Gin 135 ctt too gg ggo Leu Ser Gly Giy ogo cag cgc gc Arg Gin Arg Ala tat Tyr 145 gto gcc atg gtg Val Ala Met Val tgc caa gag acg Cys Gin Glu Thr tao gtg ott cto Tyr Val Leu Leu gaa coo oto aao Giu Pro Leu Asn aat Asn 165 547 595 643 ott gat ato goa Leu Asp Iie Ala tog gtg gaa atg Ser Val Giu Met atg Met 175 aaa 080 ctc gag Lys His Leu Giu aat got Asn Ala 180 gca gco oaa Ala Ala Gin tto goc gog Phe Ala Ala 200 ttt Phe 185 ggo ogo aoo atc Gly Arg Thr Ile atc Ile 190 gtq qtt ott oac Val Val Leu His gao ato aao Asp Ile Asn 195 cac gga atg His Gly Met ogc tao goc gat Arg Tyr Ala Asp ato gtg goc gta Ile Vai Ala Val ato gaa Ile Giu 215 aaa gag gga aoa Lys Giu Gly Thr cot Pro 220 gaa oag ato atg Giu Gin Ile Met aac gag ato ott Asn Giu Ile Leu gaa ato tto aat Giu Ile Phe Asn a oa Thr 235 gag ato gaa gtt Giu Ile Giu Val att Ile 240 gaa gga ooa oao Giu Gly Pro His ggo Gly 245 aag att got tgo Lys Ile Ala Cys tao oao Tyr His 250 taaatgaaga gaaataagoc gao 876 <210> 468 <211> 251 <212> PRT <213> Corynebaoteriun qiutarnioum <400> 468 Val Ile Thr Leu Thr Asn Val Arg Lys Giu Tyr Ser Ser Asp Val Ala 1 5 10 Ile Gly Pro Val Asn Leu Glu Ile Pro Ala Gly Gly Ile Thr Ala Leu 25 Val Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu Leu Thr Met Ile Gly 40 Arg Leu Leu Gly Ile Asp Glu Gly Asn Ile Thr Val Ala Ser Tyr Asp 55 Val Thr Ser Thr Ala Ser Lys Asp Leu Ala Lys Ile Ile Ser Ile Leu 70 75 Arg Gin Glu Asn His Phe Val Thr Lys Leu Thr Val Arg Gin Leu Val 90 Gly Phe Gly Arg Phe Pro Tyr Ser Lys Gly Arg Leu Thr Glu Glu Asp 100 105 110 Glu Gly Ile Ile Ser Arg Tyr Ile Asp Phe Phe Asn Leu Thr Glu Leu 115 120 125 Glu Asp Arg Tyr Leu Asp Gin Leu Ser Gly Gly Gin Arg Gin Arg Ala 130 135 140 Tyr Val Ala Met Val Leu Cys Gin Glu Thr Asp Tyr Val Leu Leu Asp 145 150 155 160 Glu Pro Leu Asn Asn Leu Asp Ile Ala His Ser Val Glu Met Met Lys 165 170 175 His Leu Glu Asn Ala Ala Ala Gin Phe Gly Arg Thr Ile Ile Val Val 180 185 190 Leu His Asp Ile Asn Phe Ala Ala Arg Tyr Ala Asp Tyr Ile Val Ala 195 200 205 Val Lys His Gly Met Ile Glu Lys Glu Gly Thr Pro Glu Gin Ile Met 210 215 220 Lys Asn Glu Ile Leu Ser Glu Ile Phe Asn Thr Glu Ile Glu Val Ile 225 230 235 240 Glu Gly Pro His Gly Lys Ile Ala Cys Tyr His 245 250 <210> 469 <211> 692 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (79)..(669) <223> RXA00228 <400> 469 ccgcatggca tccgccgaaa gaattcccct ccggaggaat ggcacgcctc atgggagaac gcatcggcaa aaactgacatg cgc gac ctc cgc tcc atg atc ggc gtc agc Met Arg Asp Leu Arg Ser Met Ile Gly Val Ser tcc tcc gca Ser Ser Ala cta gtc atc Leu Val Ile tta Leu ggc aac cga atc Gly Asn Arg Ile tcc gaa gaa aaa Ser Glu Glu Lys gtc tct gac Val Ser Asp cgc gaa gac Arg Giu Asp tcc gca ggc tac Ser Ala Giy Tyr atc ctc qgc cgc Ile Leu Gly Arg tac gac Tyr Asp gaa atg gac ttc Giu Met Asp Phe gga Gly 50 caa gcc acc gaa Gin Aia Thr Giu atc Ile ctc gaa caa gtc Leu Giu Gin Val gga Gly gcc atg cac cta Ala Met His Leu gac cgc acc tgg Asp Arg Thr Trp acc ctc tcc gaa Thr Leu Ser Glu gaa cqc aaa cga Giu Arg Lys Arg gtc Val1 ctg gtc gca cgc Leu Val Ala Arg gc a Al a 85 ctc atg acc aac Leu Met Thr Asn ccg gaa Pro Giu ctc ctc atc Leu Leu Ile gaa gac ctc Giu Asp Leu 110 gac gaa cca acc Asp Giu Pro Thr gga atg gac ctc Gly Met Asp Leu ggc gga cgc Gly Gly Arg 105 cca gac gca Pro Asp Ala 399 447 gtc ggc tac ctc Val Gly Tyr Leu gaa ctc gcc atg Glu Leu Ala Met cct gcc Pro Ala 125 atc gtc atg atc Ile Val Met Ile acc Thr 130 cac cac gtc qaa His His Val Giu qaa Glu 135 atc ccc gcc gga Ile Pro Ala Gly acc cac gca atg Thr His Ala Met ctc gac gaa ggt Leu Asp Giu Gly atc gta gcc caa Ile Val Ala Gin 9gC Gly 155 495 543 591 ctg atc aac aco Leu Ile Asn Thr gt c Val1 160 atq aca aac gag Met Thr Asn Giu cta tcc aaa gca Leu Ser Lys Ala ttc cac Phe His 170 cag cca atc Gin Pro Ile qtg aga acc Val Arg Thr 190 caa Gin 175 gta gac cgc atc Val Asp Arg Ile gaa cgc tac ttt Glu Arg Tyr Phe gcc cgc cgt Ala Arg Arg 185 gcc agg agt cat Ala Arg Ser His agg gct cag Arg Ala Gin 195 taggtttttt ggagttgtgg gcc <210> (211> (212> <213> 470 197 PRT Corynebacterium glutamicum <400> 470 Met Arg Asp Leu Arg Ser Met Ile Gly Val Ser Ser Ser Ala Leu Giy 1 5 10 Asn Arg Ile Pro Ser Glu Giu Lys Val Ser Asp Leu Val Ile Ser Ala 25 Gly Tyr Ala Ile Leu Gly Arg Trp Arg Giu Asp Tyr Asp Glu Met Asp 40 Phe Gly Gin Ala Thr Giu Ile Leu Giu Gin Val Gly Ala Met His Leu 55 Ala Asp Arg Thr Trp Gly Thr Leu Ser Glu Gly Glu Arg Lys Arg Vai 70 75 Leu Val Ala Arg Ala Leu Met Thr Asn Pro Giu Leu Leu Ile Leu Asp 90 Giu Pro Thr Ala Gly Met Asp Leu Gly Gly Arg Giu Asp Leu Val Gly 100 105 110 Tyr Leu Gly Glu Leu Ala Met Asp Pro Asp Ala Pro Ala Ile Val Met 115 120 125 Ile Thr His His Val Giu Giu Ile Pro Ala Giy Phe Thr His Ala Met 130 135 140 Leu Leu Asp Giu Gly Giu Ile Val Ala Gin Gly Leu Ile Asn Thr Val 145 150 155 160 Met Thr Asn Glu Asn Leu Ser Lys Ala Phe His Gin Pro Ile Gin Vai 165 170 175 Asp Arg Ile Gly Glu Arq Tyr Phe Ala Arg Arg Val Arg Thr Ala Arg 180 185 190 Ser His Arq Ala Gin 195 <210> 471 <211> 813 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101) (790) <223> RXA00346 (400> 471 atctatgaga cccctcaaaa caccgagaat ttcctcgatg cattcaccaa ggcagttgat gatctcaccg ctgccactaa ccaggtttaq aattatttaa atg ctg ttg act ttc 115 Met Leu Leu Thr Phe 1 aat gat gct gcg gtg gat ccc ctc tgg agg qgc ctg aat tta gag ctc 163 Asn Asp Ala Ala Vai Asp Pro Leu Trp Arg Gly Leu Asn Leu Giu Leu 15 cga cag ggq Arg Gin Gly tcc acg ctc Ser Thr Leu gaa Glu ttt ctt gcg qtt Phe Leu Ala Val tta Leu 30 ggC ccc aac ggc Gly Pro Asn Gly qtg gga aaa Val Gly Lys acc eac ggt Thr His Giy atc ggt acg att Ile Gly Thr Ile ttg Leu 45 ggc acc cga aaa Gly Thr Arg Lys ctc Leu tcg gtt Ser Val aaa act gat gcc Lys Thr Asp Ala gtg ggt tat att Val Gly Tyr Ile caa caa cga att Gin Gin Arg Ile gat gtc ccg ttg Asp Val Pro Leu qcc cgc gat atg Ala Arg Asp Met tcg ctg tcc gcg Ser Leu Ser Ala geg Ala cat ggc gtg gtt His Gly Val Val tce Se r aaa agg gga ccc Lys Arg Gly Pro aag ggt qac qtc Lys Gly Asp Val gat aag Asp Lys 100 ctt ett gc Leu Leu Ala gag otc tc Giu Leu Ser 120 gtq ggc gct tcc Val Gly Ala Ser ate gcc gat cga Ile Ala Asp Arg ege gtc ggc Arg Val Gly 115 cag gee ctt, Gin Ala Leu 451 499 ggc ggg cag cag Giy Gly Gin Gin eag Gin 125 etc gtc cge caa Leu Val Arg Gin gc Aila 130 qce acg Ala Thr 135 ego ccg caa tta Arg Pro Gin Leu ctt gee gac gaa Leu Ala Asp Giu ctc ctc agc ott Leu Leu Ser Leu ccc ggc gtc gcg Pro Giy Val Ala cgc acg gtg tcc Arg Thr Val Ser ttt ggt gaa ttg Phe Gly Giu Leu 547 595 643 gee gaa gge gte Ala Giu Gly Val gtt gtt gtg gtc Val Val Val Val cac gat gtc aat His Asp Vai Asn cca cta Pro Leu 180 atg ggc etg Met Gly Leu ate ggc aeg Ile Gly Thr 200 gat cgc att ttg Asp Arg Ile Leu tac Tyr 190 etc gcc ccc aae Leu Ala Pro Asn ggc cac acc Gly His Thr 195 agc gaa ctc Ser Giu Leu gtt ggo gat gte Val Giy Asp Val cag tee gaa aaa Gin Ser Giu Lys tac aac Tyr Asn 215 gca ccc gtc acg Ala Pro Val Thr gtg Val1 220 gct cgc atc aac gao aga atc gtg gtg Ala Arg Ile Asn Asp Arg Ile Val Val gtt Val1 230 taagtggatc tatccacctg got <210> 472 <211> 230 <212> PRT <213> Corynebacterium glutamicum <400> 472 Met Leu Leu Thr Phe Asn Asp Ala Ala Val Asp Pro Leu Trp Arq Giy 1 5 10 Leu Asn Leu Giu Leu Arg Gin Gly Giu Phe Leu Ala Val Leu Gly Pro 25 Asn Gly Vai Gly Lys Ser Thr Leu Ile Gly Thr Ile Leu Gly Thr Arg 40 Lys Leu Thr His Gly Ser Val Lys Thr Asp Ala Arg Val Gly Tyr Ile 55 Pro Gin Gin Arg Ilie Phe Asp Val Pro Leu Arg Ala Arg Asp Met Val 70 75 Ser Leu Ser Ala Ala His Gly Val Val Ser Lys Arg Gly Pro Ala Lys 90 Gly Asp Val Asp Lys Leu Leu Ala Arg Val Gly Ala Ser Gly Ile Ala 100 105 110 Asp Arg Arg Val Gly Glu Leu Ser Gly Gly Gin Gin Gin Leu Val Arg 115 120 125 Gin Ala Gin Ala Leu Ala Thr Arq Pro Gin Leu Leu Leu Ala Asp Giu 130 135 140 Pro Leu Leu Ser Leu Asp Pro Gly Val Ala Gin Arg Thr Val Ser Leu 145 150 155 160 Phe Gly Giu Leu Lys Ala Giu Gly Val Gly Val Val Val Val Thr His 165 170 175 Asp Val Asn Pro Leu Met Gly Leu Val Asp Arg Ile Leu Tyr Leu Ala 180 185 190 Pro Asn Gly His Thr Ile Gly Thr Val. Gly Asp Val Met Gin Ser Giu 195 200 205 Lys Leu Ser Giu Leu Tyr Asn Ala Pro Val Thr Val Ala Arg Ile Asn 210 215 220 Asp Arg Ile Val Vai Val 225 230 <210> 473 <211> 433 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(433) <223> RXA00524 <400> 473 tcctcggcac ccgctacccc gtcggagttg tcaccggcgc attcggcgcc ccattcctta tctatttact cattcgttcc aaccgcgcgq gagtaaccct ca a Gin atc Ile qtc Val1 cgc Arq ctt Leu ccg Pro ggc Giy gcc Al a ctc Leu aac As n aaa Lys ct g Leu ccc Pro cgc Arg 105 gaa Glu gt c Val1 tgc Cys agc Ser qgc Gly 75 gga Gly ccc Pro ctq Leu gtc ValI 30 t ca Ser ca a Gin cta Leu ggc Gly gga Gly 110 9cg Ala ccc Pro acg Thr 9c9 Ala gct Al a atc Ile ct C Le u Giu 10 Ser Gly Pro Pro Thr 90 His tac Tyr ggc Gly ctg Leu Ctt Le u cgc Arg gtc Val1 Giu Val1 Cys Ser Gly Gly Pro gtg Val1 1 9gc Gly aaa Lys ctg Leu atc Ile atg Met gtc Val Ile Asp Gly Ala Lys Pro His acc acc aac cat 115 Thr Thr Asn His cgc Arg acC Thr qcc Ala gcc Ala ggg Gly gac Asp Leu ValI Ser Gin Leu Gly Gly 110 a cc Thr t cc Ser ttt Phe cac His ctg Leu ctc Leu 100 Ala Pro Thr Ala Ala Ile Leu 433 <210> 474 <211> 111 <212> PP.T <213> Corynebacterium giutamicum <400> 474 Val Thr Thr Asn His Gin Leu Ser Ala 1 5 Gly Giu Arq Thr Ile Ile Asp Ser Leu 25 Lys Ile Thr Ser Ile Val Gly Pro Asn Leu Arg Ala Phe Ala Arq Leu Leu Lys 55 Ile Asp Ala His Pro Leu Pro Ser Leu 70 Met Leu Gly Leu Leu Pro Gin Ser Pro Val Ala Asp Leu Val Gly Arg Gly Arg 100 105 <210> <211> <212> <213> <220> <221> <222> <223> 475 900 DNA Corynebacterium giutamicum CDS (101)..(877) RXA0 1823 <400> 475 gcaaoacgtt gatactgagc tgoacaogoc cgttggcctg qgtgtatttg atgtggcttt tgagccgaaa ggaggcataa gtgaocagtt tgctgggcgg atg ctg caa gcg cat 1i! Met Leu Gin Ala His gat ctc acg ctg Asp Leu Thr Leu agt Ser tac ggc ggg cga Tyr Gly Gly Arg aat Asn 15 att gta gaa ggg Ile Vai Glu Gly otc agt Leu Ser ctg gac ctt Leu Asp Leu tgc ggg aaa Cys Gly Lys gaa aga ggc otc Glu Arg Gly Leu atc atc att ggo Ile Ile Ile Gly ccc aao gga Pro Asn Gly ctg aaa cca Leu Lys Pro tca aco gtt ttg Ser Thr Val Leu gcg ttg ggo aga Ala Leu Gly Arg ctg Leu caa ttg Gin Leu ggg aag atc acg Gly Lys Ile Thr ct a Leu ggt ggg cga gat Gly Gly Arg Asp too ago atg ggo Ser Ser Met Giy aag cat gtg gog Lys His Val Ala cac ato ggg gtg His Ile Gly Val cog caa coo oca Pro Gin Pro Pro tat Tyr gog ccc gat ggg Ala Pro Asp Gly agc gtc aog gag Ser Val Thr Glu ctg Le u gto ago cgo ggg Val Ser Arg Gly cqg tat Arg Tyr 100 ccg cac caa Pro His Gin gtg gog cgc Val Ala Arg 120 cat His 105 ctg ctg tog caa Leu Leu Ser Gin tog aaa gao gat Ser Lys Asp Asp gaa gcc att Glu Ala Ile 115 got gag cat Ala Glu His tog otg gog gaa Ser Leu Ala Giu ggc atg oao aco Gly Met His Thr tta gtg Leu Val 135 tog gaa ott toa Ser Giu Leu Ser ggc Giy 140 ggo cag ogo oaa Giy Gin Arg Gin cgg Arg 145 gog tgg ato gc Ala Trp Ile Ala 451 499 547 595 643 gcg cto got cag Ala Leu Ala Gin aoa gao att ttg Thr Asp Ile Leu otc gac gag 000 Leu Asp Giu Pro aog ttc cto gao Thir Phe Leu Asp goc cac oaa ata Ala His Gin Ile too Ser 175 gto oto gat tta tgo too Val Leu Asp Leu Cys Ser 180 gac ctg cac caa cgt ggt cgc ace ctg gcc att gtt cta cac gat ctg 691 Asp Leu His Gin Arg Gly Arg Thr Leu Ala Ile Val Leu His Asp Leu 185 190 195 aac atg gct gca cgg tat gcc acc cac ate atc gcc atg cgg gac ggc 739 Asn Met Ala Ala Arg Tyr Ala Thr His Ile Ile Ala Met Arg Asp Gly 200 205 210 acc atc ate gac caa gga aaa ccc gaa gaa ata etc act aaa gcg ctg 787 Thr Ile Ile Asp Gin Gly Lys Pro Glu Glu Ile Leu Thr Lys Ala Leu 215 220 225 ctc aaa gaa gtt ttt gac ctc gac gca etc ate ctc aaa gac ccc aac 835 Leu Lys Glu Val Phe Asp Leu Asp Ala Leu Ile Leu Lys Asp Pro Asn 230 235 240 245 aac ggc cga cca etc ate gtg ccc aca gac agg aga aac tea 877 Asn Gly Arg Pro Leu Ile Val Pro Thr Asp Arg Arg Asn Ser 250 255 tgaaagaaac cgacaaccta ctg 900 <210> 476 <211> 259 <212> PRT <213> Corynebacterium glutamicum <400> 476 Met Leu Gin Ala His Asp Leu Thr Leu Ser Tyr Gly Gly Arg Asn Ile 1 5 10 Val Glu Gly Leu Ser Leu Asp Leu Pro Glu Arg Gly Leu Ser Ile Ile 25 Ile Gly Pro Asn Gly Cys Gly Lys Ser Thr Val Leu Lys Ala Leu Gly 40 Arg Leu Leu Lys Pro Gin Leu Gly Lys Ile Thr Leu Gly Gly Arg Asp 55 Ile Ser Ser Met Gly Thr Lys His Val Ala Lys His Ile Gly Val Leu 70 75 Pro Gin Pro Pro Tyr Ala Pro Asp Gly Val Ser Val Thr Glu Leu Val 90 Ser Arg Gly Arg Tyr Pro His Gin His Leu Leu Ser Gin Trp Ser Lys 100 105 110 Asp Asp Glu Ala Ile Val Ala Arg Ser Leu Ala Glu Val Gly Met His 115 120 125 Thr His Ala Glu His Leu Val Ser Glu Leu Ser Gly Gly Gin Arg Gin 130 135 140 Arg Ala Trp Ile Ala Met Ala Leu Ala Gin Glu Thr Asp Ile Leu Leu 145 150 155 160 Leu Asp Glu Pro Thr Thr Phe Leu Asp Val Ala His Gin Ile Ser Val 165 170 175 Leu Asp Leu Val Leu His 195 Ser Asp Leu His Arg Gly Arg Thr Leu Ala Ile 190 His Ile Ile Asp Leu Asn Met Ala 200 Ala Arg Tyr Ala Ala Met 210 Arg Asp Gly Thr Ile Ile Asp Gin Gly Lys 215 220 Pro Glu Giu Ile Leu 225 Thr Lys Ala Leu Leu Lys Giu Val Phe 230 Asp 235 Leu Asp Ala Leu Ile 240 Leu Lys Asp Pro Asn Gly Arg Pro Ile Val Pro Thr Asp Arg 255 Arg Asn Ser <210> 477 <211> 906 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(883) <223> RXA02767 <400> 477 gggaaaacgt ttcctogccg cccacagaat cataaaaatt ttctgaggtt gtoatgggta ccagtctaag ccctqgcctt acgccagtaa ggtgttacc atg cgc gaa cta gca Met Arg Glu Leu Ala ctc aac atg 900 Leu Asn Met Ala ggo Gly gtc aco gtg cgg Val Thr Val Arg cgc Arg 15 ggc gag aaa ttg Giy Glu Lys Leu ott ctc Leu Leu qac qat ato Asp Asp Ile ggt coa aat Gly Pro Asn ctc tca att cog Leu Ser Ile Pro qqq tog cac tgg Gly Ser His Trp goc gta ctt Ala Val Leu gca gcc acc Ala Ala Thr 211 259 gqc gcc ggt aaa Gly Ala Gly Lys acc atg ctg aaq Thr Met Leu Lys ato Ile ttg Ctg Leu Leu tao cca tog gaa Tyr Pro Ser Glu 99C Gly acc gtg gac atc Thr Val Asp Ile ggg oat cgc ttt Gly His Arg Phe ggt Gly cgg gtg gat act Arg Val Asp Thr gag ctg cgg aaa Giu Leu Arg Lys atc ggc ctg gtg Ile Gly Leu Val 307 355 403 cog aag caa aga Pro Lys Gin Arg ttt Phe acc aac ctg cog Thr Asn Leu Pro cac gaa att gtg His Glu Ile Val ctg tcg Leu Ser 100 ggg tta ace Gly Leu Thr tcg gag ttg Ser Glu Leu 120 tec aac gqg ttq Ser Asn Gly Leu eca cgg tgg tcg Pro Arg Trp Ser gct tcq get Ala Ser Ala 11.5 gge atg aca Gly Met Thr gag egg tge get Giu Arg Cys Ala ttg Leu 125 atg ttg gag ttg Met Leu Glu Leu geg egt Ala Arg 135 gee gat egt tac Ala Asp Arg Tyr t gq Trp 140 gee gat atg age Ala Asp Met Ser eag Gin 145 gge gaa aaa gee Giy Giu Lys Ala ace ctg att get Thr Leu Ile Ala geg ctg att ate Ala Leu Ile Ile ceg ace eta ctg Pro Thr Leu Leu ett gat gaa cee Leu Asp Glu Pro ace Thr 170 ace gge ctt gac Thr Gly Leu Asp ctg Le u 175 eec gga cgt gaa Pro Gly Arg Glu act ttg Thr Leu 180 etc agt gtg Leu Ser Val gtg atg ate Val Met Ile 200 gat ggt ttg cga Asp Gly Leu Arg get ctt cet ggt Ala Leu Pro Gly ctg acg aca Leu Thr Thr 195 acg aca gat Thr Thr Asp 691 739 acc eac cae gte Thr His His Val gaa Glu 205 gag ate gee gcc Giu Ile Ala Ala tee Ser 210 ate etc Ile Leu 215 atg ate aag gac Met Ile Lys Asp cge ata etg get Arg Ile Leu Ala teg Ser 225 ggg act gtt tea Gly Thr Val Ser gtg atg aet ect Val Met Thr Pro aat ttg gge geg Asn Leu Gly Ala tat gae atg teg Tyr Asp Met Ser 787 835 883 teg ttg gaa act Ser Leu Glu Thr gtg Val1 250 ege age cgg tgg Arg Ser Arq Trp geg ttc gat get Ala Phe Asp Ala etg cat Leu His 260 taaaagggge tagttttaea caa <210> 478 <211> 261 <212> PRT <213> Corynebacterium giutamicum <400> 478 Met Arg Glu Leu Ala Leu Asn Met Ala Gly 1 5 10 Val Thr Val Arg Arg Gly Giu Lys Leu Leu Leu Asp Asp Ile Ser 25 His Trp Ala Val Leu Giy Pro Asn Gly 40 Leu Ser Ile Pro Gin Gly Ser Thr Met Leu Ala Gly Lys Thr Lys Ile Ala Ala Thr Leu Leu Tyr Pro Ser Glu Giy 55 Thr Val Asp Ile Leu Gly His Arg Phe Ile Giu T rp Le u Gin 145 Pro Giy Pro Ala Ser 225 T yr Phe Gi y Ile Ser Val1 130 Giy Thr Arg Gly Ser 210 Giy Asp Asp Leu Val1 Aia 115 Giy Giu Leu Giu Le u 195 Thr Thr Met Aila Val Asp Leu Ser 100 Ser Ala Met Thr Lys Ala Leu Leu 165 Thr Leu 180 Thr Thr Thr Asp Vai Ser Ser Val 245 Leu His 260 Gly Pro Gly Ser Al a Arg 150 Le u Le u Val1 Ile Giu 230 Ser Arg Vai Asp Thr Arg Giu Leu Arg Lys Thr Lys Leu Glu Arg 135 Thr Asp Ser Met Leu 215 Val1 Arg Ala 105 Glu Asp Ile Pro Ile 185 Thr Ile Thr Phe 90 Ser Arg Arg Ala Thr 170 Asp His Lys Pro Thr As n Cys T yr Arg 155 Thr Gly His Asp Glu 235 Asn Gly Ala Trp 140 Al a Giy Leu Val1 Al a 220 As n Leu Leu Leu 125 Al a Leu Leu Arg Glu 205 Arg Leu Pro Leu 110 Met Asp Ile Asp Ala 190 Glu Ile G ly' Al a Pro Leu Met Ile Leu 175 Ala Ile Leu Al a Leu Giu Thr Val Arg Ser Arg Trp Phe Ala (210> 479 <211> 876 <212> DNA (213> Corynebacterium glutamicum <220> (221> CDS <222> (101)..(853) <223> RXA02792 <400> 479 agaacaaagt gctgcccata ctcatgaact ttgccgaacc cccaaccccg ctggccgtcg atggcctaga aaaaatcatc gactttgtgq aaacccaccc atg atc gag gcc aca Met Ile Glu Ala Thr 1 cac cta cgc cac agt ttt ggc gac aac atc gtc atc gat gac gtc acc His Leu Arg His Ser Phe Gly Asp Asn Ile Val Ile Asp Asp Val Thr 15 115 163 ctc cat cta Leu His Leu agt ggc aaa Ser Gly Lys gca cac ggc acc Ala His Gly Thr agc ttg gtc ggc Ser Leu Val Gly ccc aac gqc Pro Asn Gly ctg caa cca Leu Gin Pro acc acc ctg ctg cgt gca cta tac gga Thr Thr Leu Leu Arg Ala Leu Tyr Gly gca Ala aat gaa Asn Glu ggg cac atc cac Gly His Ile His gat ggc gtt cca Asp Gly Val Pro ata agc ttg cac Ile Ser Leu His cgc Arg aaa gac atc gca Lys Asp Ile Ala acc atg gcc gta Thr Met Ala Val gtc ValI 80 atc caa gaa cat Ile Gin Glu His gac Asp tcc gac ctc ccc Ser Asp Leu Pro atg Met acc gtc gct gac Thr Val Ala Asp gtc tta cta ggc Val Leu Leu Gly aga ctc Arg Leu 100 ccc cac caa Pro His Gin gtt aag gaa Val Lys Glu 120 atg ttt gcc ggc Met Phe Ala Gly tct caa gct gat Ser Gin Ala Asp cag tta ctc Gin Leu Leu 115 goc gac cqa Ala Asp Arg gca ctc acc cga Ala Leu Thr Arg gtc Val1 125 ggc gcc att cac Gly Ala Ile His ctg Leu 130 caa ttc Gin Phe 135 ggc gca ctt tca Gly Ala Leu Ser ggc Gly 140 ggt gaa cgc caa Gly Glu Arg Gin cgc Arg 145 gtc ctc atc gca Val Leu Ile Ala cga Arg 150 gca ctc gta caa Ala Leu Val Gin aac Asn 155 gcc aca cac att Ala Thr His Ile ctg Leu 160 ctc gac gaa ccc Leu Asp Giu Pro acc Thr 165 547 595 643 aac cac ctc gac Asn His Leu Asp ato Ile 170 cgc tac cag cac Arg Tyr Gin His gaa Glu 175 gtc ctt cac otc Val Leu His Leu gto cgc Val Arg 180 gaa ctc agc Giu Leu Ser ggt gcc tao Gly Ala Tyr 200 tca Ser 185 agt too atc atc Ser Ser Ile Ile ctc cac gac ota Leu His Asp Leu aac ctc gca Asn Leu Ala 195 cqt gtg qtt Arg Vai Val ago gac cac atc Ser Asp His Ile ctc ott gac caa Leu Leu Asp Gin gga Gly 210 act caa Thr Gin 215 gga acg ccc tca Gly Thr Pro Ser gta ttg acc cca Val Leu Thr Pro gag Glu 225 cat ttg gaa cot His Leu Glu Pro tat ggc gtt cgt Tyr Gly Val Arg gt t Val1 235 gag cgc ttt gao Glu Arg Phe Asp cta Leu 240 ggc gat gaa gto Gly Asp Glu Val cac His 245 ott cgg ttc aag Leu Arg Phe Lys cgt cac Arg His 250 taggagtttt gttgaggagg tgg <210> 480 <211> 251 <212> PRT <213> Corynebacterium glutamicun <400> 480 Met Ile Giu Ala Thr His Leu Arg His Ser Phe Gly Asp Asn Ile Val 1 Ile Val1 Gl y Le u Ile Leu Al a His Arg 145 Leu Leu Asp Gin Giu 225 Gi y Asp Gly Ala Ile Gin Leu Asp Leu 130 Val1 Asp His Leu Gly 210 His Asp ValI As n Gin Le u His Arg 100 Le u Asp Ile Pro Val 180 Le u Val1 Glu Val1 5 Thr Gly Pro His Asp Leu Le u Arg Ala Thr 165 Arg Al a Val1 Pro His 245 His Gly Giu Lys Asp His Lys Phe 135 Al a His Leu Al a Gin 215 Tyr Arg Leu Lys Gly Asp Leu Gin Glu 120 Gly Leu Leu Ser Tyr 200 Gly Gly Phe 10 Al a Thr Ile Ala Met 90 Met Le u Leu Gin Ile 170 Se r Asp Pro Arg Arg 250 His Le u His Lys 75 Thr Phe Thr Ser As n 155 Arg Ser His Se r Val1 235 His Thr Arg Asp Met Ala Gly Val1 125 Gly Th r Gin Ile Ile 205 Val1 Arg Val1 Al a dly Ala Asp Asn 110 Gly Glu His His Val1 190 Leu Leu Phe Ser Leu Val1 Val1 Leu Ser Ala Arg Ile Giu 175 Leu Le u Thr Asp Le u Tyr Pro Val1 Val1 Gin Ile Gin Leu 160 Val1 His Asp Pro Leu 240 <210> 481 <211> 1161 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (1138) <223> RXN02929 <400> 481 caggtgggqa cctcgcgtat cccagctggt gqaagaaatc tgcttcttct gaagctgtgc cggccgctgc ttaaqttttc gcagcgcagt tqaatcagct gtg ctg aag aga att 115 Val Leu Lys Arg Ile ttc ctc aac ccc Phe Leu Asn Pro gtg gct acc gcg Val Ala Thr Ala ttg Leu tcg gta gtc att Ser Val Val Ile ttg ggg Leu Gly ttt gtg gtg Phe Val Val aca gca gtg Thr Ala Val ttt tca ggt ttt Phe Ser Gly Phe ggt gtt att gat Gly Val Ile Asp tta agc ccc Leu Ser Pro acc cct cga Thr Pro Arg 211 259 att aga cat ttg Ile Arg His Leu agt Ser ggg cag gac acg Gly Gin Asp Thr gat cag Asp Gin gcc ato ttc ttt Ala Ile Phe Phe ato cgg ctg oct Ile Arg Leu Pro att atc gct ggt Ile Ile Ala Gly gtc Val att gtc gga gca Ile Val Gly Ala acg Thr ctg gct att tot Leu Ala Ile Ser gct tct tao caa Ala Ser Tyr Gin gta ttt aga aac Val Phe Arg Asn Cogq Pro Ctg got gat cot Leu Ala Asp Pro tat Tyr 95 ttg ttg ggt gtq Leu Leu Gly Val toc gca Ser Ala 100 ggt tct ggc Giy Ser Gly gga ttt tct Gly Phe Ser 120 ggt qtc acg gca Gly Val Thr Ala att gtt ggc ggt Ile Vai Gly Gly acc gtg ctg Thr Val Leu 115 ttt gta ggt Phe Val Gly 451 499 gca ccg ago atc Ala Pro Ser Ile ggc Gly 125 gtg att ggt gca Val Ile Gly Ala ggt gtt Gly Val 135 gcc gca gta ctt Ala Ala Val Leu gc Ala 140 acg ctg atg gtg Thr Leu Met Val cgg gga gta gga Arg Gly Val Gly gga tca tca acc Gly Ser Ser Thr gtg gtt att ttg Val Val Ile Leu gog Ala 160 ggc gtg gcg gtt Gly Val Ala Vai gct ttt gcc agt Ala Phe Ala Ser ato cag aco tat Ile Gin Thr Tyr cag caa cga oac Gin Gin Arg His atc gat Ile Asp 180 acg gtg gcg Thr Val Ala gta tat gq tgq Val Tyr Val Trp atg Met 190 ttg gqc aac ctc Leu Gly Asn Leu aat qtc acc Asn Val Thr 195 aac tgg atg tcg atc ttc atc qtq got qtq gtg qcg qqa ota tqo qcg Asn Trp Met Ser Ile Phe Ile Val Ala Val Val Ala Gly Leu Cys Ala 739 200 205 210 gce gtg atc atg tcc tgc gcc agg ttg tta gac gtg atg get gtt ggt 787 Ala Val Ile Met Ser Cys Ala Arg Leu Leu Asp Val Met Ala Val Gly 215 220 225 gat gtg gaa gcc cgc aca ttg ggc gtc gat cca ggc ctc gta cgc att 835 Asp Val Glu Ala Arg Thr Leu Gly Val Asp Pro Gly Leu Val Arg Ile 230 235 240 245 ggc att gte ate gtg gca acc ctt ggt aca get gca gtg gta tcc att 883 Gly Ile Val Ile Val Ala Thr Leu Gly Thr Ala Ala Val Val Ser Ile 250 255 260 tcc ggt cte atc ggg ttt gtg ggc ate att gtt ccg cac gcc etg cgc 931 Ser Gly Leu Ilie Gly Phe Val Gly Ile Ile Val Pro His Ala Leu Arg 265 270 275 eta att gtt ggc ccg ggg cat egg att tta ctg cca ctg tct ttc gta 979 Leu Ile Val Gly Pro Gly His Arg Ile Leu Leu Pro Leu Ser Phe Val 280 285 290 tgg ggt gee att tte etc gtg ttg qca gat ace gca qgg ega aca ttg 1027 Trp Gly Ala Ilie Phe Leu Val Leu Ala Asp Thr Ala Gly Arg Thr Leu 295 300 305 atg get cet eag gaa ctt ccc gtg gqt gtg gtg aca get gea etc gge 1075 Met Ala Pro Gln Giu Leu Pro Val Gly Val Val Thr Ala Ala Leu Gly 310 315 320 325 gca ceg ttc ttc tta ttt att ttg ege aga ace age aga eaa ega gtt 1123 Ala Pro Phe Phe Leu Phe Ile Leu Arq Arg Thr Ser Arg Gin Arg Val 330 335 340 eca aaa agg agt get taagtggcga tcattgaatg ega 1161 Pro Lys Arg Ser Ala 345 <210> 482 <211> 346 <212> PRT <213> Corynebacterium glutamicur <400> 482 Val Leu Lys Arg Ile Phe Leu Asn Pro Trp Val Ala Thr Ala Leu Ser 1 5 10 Val Val Ile Leu Gly Phe Val Val Leu Phe Ser Gly Phe Ser Gly Val 25 Ile Asp Leu Ser Pro Thr Ala Val Ile Arg His Leu Ser Gly Gin Asp 40 Thr Leu Thr Pro Arg Asp Gin Ala Ile Phe Phe Asp Ile Arg Leu Pro 55 Arg Ile Ile Ala Giy Val Ile Val Gly Ala Thr Leu Ala Ile Ser Gly 70 75 Ala Ser Tyr Gin Ala Val Phe Arq Asn Pro Leu Ala Asp Pro Tyr Leu 90 Leu Gly Val Ser Ala Gly Ser Gly Leu Gly Val Thr Ala Val Ile Val 100 105 110 Gly Gly Thr Val Leu Gly Phe Ser Ala Pro Ser Ile Gly Val Ile Gly 115 120 125 Ala Ala Phe Val Gly Gly Val Ala Ala Val Leu Ala Thr Leu Met Val 130 135 140 Ser Arg Gly Val Giy Gin Gly Ser Ser Thr Thr Val Val Ile Leu Ala 145 150 155 160 Giy Val Ala Val Ala Ala Phe Ala Ser Ser Ile Gln Thr Tyr Ile Gin 165 170 175 Gin Arg His Ile Asp Thr Val Ala Arg Val Tyr Val Trp Met Leu Gly 180 185 190 Asn Leu Asn Val Thr Asn Trp Met Ser Ile Phe Ile Val Ala Val Val 195 200 205 Ala Gly Leu Cys Ala Ala Val Ile Met Ser Cys Ala Arg Leu Leu Asp 210 215 220 Val Met Ala Val Gly Asp Val Glu Ala Arg Thr Leu Gly Val Asp Pro 225 230 235 240 Gly Leu Vai Arg Ile Gly Ile Val Ile Val Ala Thr Leu Gly Thr Ala 245 250 255 Ala Val Val Ser Ile Ser Gly Leu Ile Gly Phe Val Gly Ile Ile Val 260 265 270 Pro His Ala Leu Arg Leu Ile Val Gly Pro Gly His Arg Ile Leu Leu 275 280 285 Pro Leu Ser Phe Val Trp Gly Ala Ile Phe Leu Val Leu Ala Asp Thr 290 295 300 Ala Gly Arq Thr Leu Met Ala Pro Gin Glu Leu Pro Val Gly Val Val 305 310 315 320 Thr Ala Ala Leu Gly Ala Pro Phe Phe Leu Phe Ile Leu Arg Arg Thr 325 330 335 Ser Arg Gin Arg Val Pro Lys Arg Ser Ala 340 345 <210> 483 (211> 1095 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(1072) (223> FRXA01235 <400> 483 ttctgaagct gtgccggccg ctgcttaagt tttcgtgctg ctgggtggct accgcgttgt cggtagtcat tttggggttt aagagaattt tcctcaaccc Val Val Leu Phe Ser ggt ttt agc ggt Gly Phe Ser Gly gtt Val1 att gat tta agc Ile Asp Leu Ser aca gca qtq att Thr Ala Val Ile aqa cat Arg His ttg agt ggg Leu Ser Giy gat atc cg Asp Ile Arg gac acg ctc acc Asp Thr Leu Thr cct Pro cga gat cag gcc Arg Asp Gin Ala atc ttc ttt Ile The Phe gga gca acg Gly Ala Thr ctg cct cga att Leu Pro Arg Ile gct ggt gtc att Ala Gly Val Ile gtc Val1 *ctg gCt Leu Ala att tct ggt gct Ile Ser Gly Ala tac caa gcg gta Tyr Gin Ala Val aga aac ccg ctg Arq Asn Pro Leu gC t Al a gat cct tat ttg Asp Pro Tyr Leu ggt gtg tcc gca Gly Val Ser Ala ggt Gly 80 tct ggc ctt ggt Ser Gly Leu Gly gtC Val acg gca gtg att Thr Ala Val Ile ggc ggt acc gtg Gly Gly Thr Val gga ttt tct gca Gly Phe Ser Ala ccg agc Pro Ser 100 atc ggc gtg Ile Gly Val gcc acg ctg Ala Thr Leu 120 qgt gca qca ttt Gly Ala Ala Phe gt a Val1 110 ggt ggt gtt gCC Gly Gly Val Ala gca gta ctt Ala Val Leu 115 tca acc acc Ser Thr Thr atg gtg agt cgg Met Val Ser Arg gqa Gly 125 gta gga cag gga Val Gly Gln Gly t ca Se r 130 gtg qtt Val Val 135 att ttg gcg gqc Ile Leu Ala Gly qCg gtt gCt got Ala Val Ala Ala ttt Phe 145 gcc agt tcc atc Ala Ser Ser Ile cag Gin 150 acc tat att cag Thr Tyr Ile Gin cga cac atc gat Arg His Ile Asp gtg gcg cgc gta Val Ala Arg Val qtg tgq atg ttg Val Trp Met Leu ggC Gly 170 aac ctc aat gtc Asn Leu Asn Val acc Thr 175 aac tgg atg tcg Asn Trp Met Ser atc ttc Ile Phe 180 ato gtg gct Ile Val Ala qcc aqg ttg Ala Arg Leu 200 gtg gcg gga cta Val Ala Gly Leu qog qoc gtg atc Ala Ala Val Ile atg tcc tgc Met Ser Cys 195 gcc cgc aca Ala Arg Thr 691 739 tta gac gtg atg Leu Asp Val Met gtt ggt gat gtg Val Gly Asp Val ttg ggc gtc gat cca ggc ctc gta cgc att ggc att gtc aic gtg gca Leu Gly Val Asp Pro Gly Leu Val Arg Ile Gly Ile Val Ile Val Ala 215 220 225 acc ctt ggt aca gct gca gtg gta tcc att tcc ggt ctc atc ggg ttt 835 Thr Leu Gly Thr Ala Ala Val Val Ser Ile Ser Gly Leu Ile Gly Phe 230 235 240 245 gtg ggc atc att gtt ccg cac gcc ctg cgc cta att gtt ggc ccg ggg 883 Val Gly Ile Ile Val Pro His Ala Leu Arq Leu Ile Val Gly Pro Gly 250 255 260 cat cqg att tta ctg cca ctq tct ttc gta tgq ggt gcc att ttc ctc 931 His Arg Ile Leu Leu Pro Leu Ser Phe Val Trp Giy Ala Ile Phe Leu 265 270 275 gtg ttg gca gat acc gca ggg cga aca ttg atg gct cct cag gaa ctt 979 Val Leu Ala Asp Thr Ala Gly Arg Thr Leu Met Ala Pro Gin Giu Leu 280 285 290 ccc gtg ggt gtg gtg aca gct gca ctc ggc gca ccg ttc ttc tta ttt 1027 Pro Vai Gly Val Vai Thr Ala Ala Leu Gly Ala Pro Phe Phe Leu Phe 295 300 305 ati ttg cgc aga acc agc aga caa cga gtt cca aaa aqq agt gct 1072 Ile Leu Arg Arg Thr Ser Arg Gin Arg Val Pro Lys Arg Ser Ala 310 315 320 taagtqqcga tcattgaatq cga 1095 <210> 484 <211> 324 <212> PRT <213> Corynebacterium giutamicum <400> 484 Val Val Leu Phe Ser Giy Phe Ser Giy Val Ile Asp Leu Ser Pro Thr 1 5 10 Ala Val Ile Arg His Leu Ser Giy Gin Asp Thr Leu Thr Pro Arg Asp 25 Gin Ala Ile Phe Phe Asp Ile Arg Leu Pro Arg Ile Ile Ala Gly Val 40 Ile Vai Gly Ala Thr Leu Ala Ile Ser Gly Ala Ala Tyr Gin Ala Val 55 Phe Arg Asn Pro Leu Ala Asp Pro Tyr Leu Leu Gly Val Ser Ala Gly 70 75 Ser Gly Leu Gly Val Thr Ala Vai Ile Val Gly Gly Thr Val Leu Gly 90 Phe Ser Ala Pro Ser Ile Giy Vai Ile Giy Ala Ala Phe Val Gly Gly 100 105 110 Val Ala Ala Val Leu Ala Thr Leu Met Val Ser Arg Gly Val Gly Gin 115 120 125 Gly Ser Ser Thr Thr Val Val Ile Leu Ala Gly Val Ala Val Ala Ala 130 135 140 Phe Ala Ser Ser Ile Gin Thr Tyr Ile Gin Gin Arg His Ile Asp Thr 145 150 155 160 Val Ala Arg Val Tyr Val Trp Met Leu Gly Asn Leu Asn Vai Thr Asn 165 170 175 Trp Met Ser Ile Phe Ile Val Ala Val Val Ala Gly Leu Cys Ala Ala 180 185 190 Val Ile Met Ser Cys Ala Arg Leu Leu Asp Val Met Ala Val Gly Asp 195 200 205 Val Giu Ala Arg Thr Leu Gly Val Asp Pro Gly Leu Val Arg Ile Giy 210 215 220 Ile Vai Ile Val Ala Thr Leu Giy Thr Ala Ala Vai Val Ser Ile Ser .225 230 235 240 Gly Leu Ile Gly Phe Val Giy Ile Ile Val Pro His Ala Leu Arg Leu 245 250 255 Ile Val Gly Pro Gly His Arg Ile Leu Leu Pro Leu Ser Phe Val Trp 260 265 270 Gly Ala Ile Phe Leu Val Leu Ala Asp Thr Ala Gly Arg Thr Leu Met 275 280 285 Ala Pro Gin Glu Leu Pro Val Gly Vai Val Thr Ala Ala Leu Gly Ala 290 295 300 Pro Phe Phe Leu Phe Ile Leu Arg Arg Thr Ser Arg Gin Arg Val Pro :305 310 315 320 Lys Arg Ser Ala <210> 485 <211> 1197 <212> DNA <213> Corynebacterium giutamicum <220> <221> COS <222> (1174) <223> RXNO2?94 <400> 485 gcgcccactc atcggcgaqc ttcagqagat gaggttgatg ctccattgat aatttctttc gctaatagtc aaatgatcat ttgagtgtta gtgttttctc atg ctt ctt tcc qcc 115 Met Leu Leu Ser Ala 1 cgc aca cac acg agt ttc caa gaa ctt gga ctc aat gct agt cgg cqc 163 Arg Thr His Thr Ser Phe Gin Giu Leu Gly Leu Asn Ala Ser Arq Arg 15 aaa gca atc aac tgg aca ctg gca ctc act gtg gtg cta att gcc tcc 211 Lys Ala Ile Asn Trp Thr Leu Ala Leu Thr Val Val Leu Ile Ala Ser atg Ltt gtt Met Phe Val ggc gtq ctc atc Gly Val Leu Ile ggt Gly 45 gca tcc ggg acc Ala Ser Gly Thr t ca Ser gtg ttt tcc Val Phe Ser 259 acg tgg acc gta att agc Thr Trp Thr Val Ile Ser cat ctt ttt ggc His Leu Phe Gly act gag cta ggt ggc Thr Glu Leu Gly Giy cgc acc cca cgc gtc Arg Thr Pro Arg Val gac act gcc gac Asp Thr Ala Asp gcc Ala atc att tgg tac Ile Ile Trp Tyr atc Ile 307 355 403 ttg ctc gct gcc Leu Leu~ Ala Ala gtg ggc gca ggc Val Gly Ala Gly gcc ctg gca ggt Ala Leu Ala Gly gcc atc Ala Ile 100 atq caa gta Met Gin Val qtg aac tca Val Asn Ser 120 gtc cga aac atg Val Arg Asn Met gca qac ccc tat Ala Asp Pro Tyr atc ctc ggg Ile Leu Gly 115 ctg ttc gga Leu Phe Gly 451 499 ggt qcc agt tgc Gly Ala Ser Cys ggt Gi y 125 gcg qcc gct gcc Ala Ala Ala Ala gtg ggc Val Gly 135 gct qga ttt ggc Ala Gly Phe Gly tac gcc ctc caa Tyr Ala Leu Gin agc gcq ttt ctc Ser Ala Phe Leu ggc Gly 150 gca atg gca gct Ala Met Ala Ala t cc Ser 155 gqa ttq atc ttc Gly Leu Ile Phe ttc Phe 160 qtg gog cgc gca Val Ala Arg Ala 547 595 643 ggg cgc atc tcc Gly Arg Ile Ser acc cgc ttg ttg Thr Arg Leu Leu tcc ggc gta gog Ser Gly Val Ala atc gga Ile Gly 180 tac atg ctc Tyr Met Leu gcc gaa ggc Ala Giu Gly 200 gcg qca aca agc Ala Ala Thr Ser ctc atc ttc tcc Leu Ile Phe Ser tcc gac tcc Ser Asp Ser 195 tcc tta gga Ser Leu Gly agc cgc tcc gtg Ser Arg Ser Val ttg Leu 205 ttc tgg ctg ctt Phe Trp Leu Leu gga Gly 210 ctt gcc Leu Ala 215 gca tgg aat ggg Ala Trp Asn Gly atg gcg atc atc Met Ala Ile Ile ctc atc gtg ggc Leu Ile Val Gly gcc ctg gcg ttg Ala Leu Ala Leu atg gtg ttg ggt Met Val Leu Gly ccg Pro 240 caa ttg gat gcc Gin Leu Asp Ala tta Leu 245 aac tcc gqc gat Asn Ser Gly Asp gaa Glu 250 acc gca ctt acc Thr Ala Leu Thr gga gta tcc cct Gly Val Ser Pro gat cgc Asp'Arg 260 ctc cgc att Leu Arg Ile ctc ctg gtg atc Leu Leu Val Ie tgc ctq ctq qtq Cys Leu Leu Val qga tcc atg Gly Ser Met 275 gtt gcc atg gee ggc age atc gga ttc atc ggc ett gte atc ccc eac 979 Val Ala Met Ala Gly Ser Ile Gly Phe Ile Gly Len Val Ile Pro His 280 285 290 ctg gcc agg cgt ttt gtt agt gga aaa cac cga ctc atg ctg cct gta 1027 Len Ala Arq Arg Phe Val Ser Gly Lys His Arg Leu Met Len Pro Val 295 300 305 tcc gcg ttg atg ggc gca att ttg ctc atc tgg gct gat ate gcc qcc 1075 Ser Ala Leu Met Gly Ala Ile Leu Len Ile Trp Ala Asp Ile Ala Ala 310 315 320 325 cgc acc ctg ctt gcg ccc caa gag att ccc ate ggc ate atc acc gca 1123 Arg Thr Leu Leu Ala Pro Gin Glu Ile Pro Ile Gly Ile Ile Thr Ala 330 335 340 ctc atc gqa gca ccc ttc ctc ctg att ctg gtt cgc cgg atq cac ace 1171 Leu Ile Gly Ala Pro Phe Leu Leu Ile Len Val Arg Arg Met His Thr 345 350 355 tac tgatttttaa ggaattatgc gta 1197 Tyr <210> 486 <211> 358 <212> PRT (213> Corynebacterium gintamicum <400> 486 Met Leu Leu Ser Ala Arg Thr His Thr Ser Phe Gin Gin Leu Gly Leu 1 5 10 Asn Ala Ser Arq Arg Lys Ala Ile Asn Trp Thr Leu Ala Len Thr Val 25 Val Leu Ile Ala Ser Met Phe Val Gly Val Leu Ile Gly Ala Ser Giy 40 Thr Ser Val Phe Ser Thr Trp Thr Val Ile Ser His His Leu Phe Gly 55 Thr Glu Len Gly Gly Ser Asp Thr Ala Asp Ala Ile Ile Trp Tyr Ile 70 75 Arg Thr Pro Arg Val Leu Leu Ala Ala Ile Val Gly Ala Gly Len Ala 90 Leu Ala Gly Ala Ile Met Gin Val Len Val Arg Asn Met Leu Ala Asp 100 105 110 Pro Tyr Ile Leu Gly Val Asn Ser Gly Ala Ser Cys Gly Ala Ala Ala 115 120 125 Ala Leu Leu Phe Gly Val Gly Ala Gly Phe Gly Asp Tyr Ala Len Gin 130 135 140 Gly Ser Ala Phe Leu Gly Ala Met Ala Ala Ser Gly Len Ile Phe Phe 145 150 155 160 Val Gly Phe Leu Phe 225 Gin Val1 Leu Leu Leu 305 Ala Gly Arg Ala Val1 Ser Gl y 2.10 Le u Le u Ser Val1 Val1 290 Met Asp Ile Arq Arg Ala Ala Gly 165 Ala Ile Gly Tyr 180 Ser Asp Ser Ala 195 Ser Leu Gly Leu Ile Val Gly Ilie 230 Asp Ala Leu Asn 245 Pro Asp Arg Leu 260 Gly Ser Met Val 275 Ilie Pro His Leu Leu Pro Val Ser 310 Ile Ala Ala Arg 325 Ile Thr Ala Leu 340 Met His Thr Tyr 355 A rgc Met Glu Al a 215 Ala Ser Arg Ala Ala 295 Ala Thr Ile Ile Le u Gi y 200 Al a Le u Gi y Ile Met 280 Arg Le u Le u Ser Ser 1.70 Ser Ala 185 Ser Arg Trp Asn Ala Leu Asp Glu 250 Leu Leu 265 Ala Gly Arg Phe Met Gly Leu Ala 330 Tb r Al a Se r Gi y Leu 235 Thr Le u Ser ValI Ala 315 Pro Arg Thr Val1 Pro 220 Met Ala Val Ile Ser 300 Ile Gin Leu Se r Leu 205 Met Val1 Leu Ile Gly 285 Gly Leu Giu Leu Phe 190 Phe Ala Leu Thr Thr 270 Phe Lys Leu Ile Met 175 Leu Trp Ile Gly Leu 255 Cys Ile His Ile Pro Se r Ile Leu Ile Pro 240 Gly Le u Gly Arg Trp 320 Ile 335 Gly Ala Pro Phe Leu Leu Ile Leu Val 345 350 <210> 487 <211> 364 <212> DNA <213> Corynebacterium giutarnicum. <220> <221> CDS <222> (364) <223> FRXA01419 <400> 487 gcgcccactc atcggcgagc ttcaggagat gaggttgatg ctccattgat aatttctttc qctaatagtc aaatqatcat ttgaqtqtta qtqttttctc atg ctt ctt tcc qcc 115 Met Leu Leu Ser Ala 1 cgc aca cac acg agt ttc caa gaa ctt gga ctc aat gct agt cqg cgc 163 Arg Thr His Thr Ser Phe Gin Glu Leu Gly Leu Asn Ala Ser Arg Arg 15 gca Ala ttt Phe tgg Trp ga c Asp Ct C Le u atc Ile gtt Val2 aCC Thr act Thr gct Ala aac Asn 99C Gly gta Val1 gCC Al a ctg Le u atc Ile cac His atc Ile ct C Le u gca Ala Ct t Leu tgg Trp act Thr tcc Ser ttt Phe tac Tyr cta Le u tca Ser gag Glu acc Thr t cc Ser tcc Se r ggc; Gi y gt c Val1 <210> 488 <211> 88 <212> PRT <213> Corynebacteriun giutamicum <400> 488 Met Leu Leu Ser Ala Arg Thr His Thr Ser 1 5 10 Asn Ala Ser Arg Arg Lys Ala le Asn Trp 25 Val Leu Ile Ala Ser Met Phe Val Gly Val 40 Thr Ser Val Phe Ser Thr Trp, Thr Val Ile 55 Thr Glu Leu Cly Gly Ser Asp Thr Ala Asp 70 Arg Thr Pro Arg Val Leu Leu Ala Phe Gin Glu Leu Gly Thr Leu Ala Leu Thr Leu Ile Gly Ala Ser Ser His His Leu Phe Ala Ile Ile Trp, Tyr <210> 489 <211> 744 <212> DNA <213> Corynebacterium giutamicum <220> <221> COS <222> (721) <223> FRXA02794 <400> 489 tgaactcagq tgccagttgc ggtgcggccg ctgccttact gttcqgagtg ggcqctggat ttggcgatta cgccctccaa gcagcgcgtt tctcggcgca atq gca qct tcc gga 115 Met I Ala Ala Ser ttg ate ttc ttc Leu Ile Phe Phe geg egc gca geg Ala Arg Ala Ala cge atc tcc teg Arg Ile Ser Ser acc cgc Thr Arg ttg ttg atg Len Len Met agc ttt etc Ser Phe Leu tdc Ser ggc gta geg ate Gly Val Ala Ile gga Gly 30 tac atg ctc tct Tyr Met Leu Ser gcg gca aca Ala Ala Thr cgc tcc gtg Arg Ser Val atc ttc tcc tcc Ile Phe Ser Ser tee gee gaa ggc Ser Ala Gin Gly ttg ttc Len Phe tgg ctg ctt gga Trp Leu Leu Gly tee Ser tta gga ctt gee Leu Gly Len Ala tgg aat ggg ccg Trp Asn Giy Pro atg Met qcg ate ate ttc Ala Ile Ile Phe atc gtg ggc att Ile Val Gly Ile gee Al a ctg gcg ttg etc Len Ala Leu Leu gtg ttg qgt ceg Vai Len Gly Pro ttg gat gee tta Len Asp Ala Leu tee gge gat gaa Ser Gly Asp Gin ace gea Thr Ala 100 ett ace ttg Len Thr Len ate ace tgc Ile Thr Cys 120 gga Gi y 105 gta tee cot gat Vai Ser Pro Asp ege Arg 110 etc ege att etc Len Arg Ile Len etc etg gtg Len Len Val 115 gge age ate Gly Ser Ile etg ctg gtg gga Len Len Vai Gly atg gtt gee atg Met Val Ala Met gga tte Gly Phe 135 ate ggc ott gte Ile Giy Len Vai ate Ile 140 eec eae etg gee Pro His Leu Ala egt ttt gtt agt Arg Phe Val Ser gga Gly 150 aaa eac ega ete Lys His Arg Leu atg Met 155 etg ect gta tee Leu Pro Val Ser geg Ala 160 ttg atg ggc gca Leu Met Giy Ala att Ile 165 547 595 643 ttg etc ate tgg Len Len Ile Trp gat ate gee gee Asp Ile Ala Ala ace etg ett geg Thr Len Len Ala eec caa Pro Gin 180 gag att ccc Glu Ile Pro etg att. etg Len Ile Len 200 gge ate ate ace Gly Ile Ile Thr gea Ala 190 etc ate gga gca Len Ile Gly Ala ccc ttc etc Pro Phe Leu 195 gtt ege egg atg Val Arg Arg Met cac ace tac His Thr Tyr 205 tgatttttaa ggaattatge <210> 490 <211> 207 <212> PRT <213> Corynebacteriun glutamicum <400> 490 Met Ala Ala Ser 1 Ile Ser Ser Thr Leu Ser Ala Ala Gly Ser Arg Ser Ala Trp Asn Gly Leu Ala Leu Leu Gly Asp Giu Thr 100 Ile Leu Leu Leu 115 Met Ala Giy Ser 130 Arg Arg Phe Val 145 Leu Met Giy Ala Leu Leu Ala Pro 180 Gly Ala Pro Phe 195 <210> 491 <211> 1140 <212> DNA Gly 5 Arg Thr Val1 Pro Met Ala Val Ile Ser Ile 165 Gin Le u Leu Ile Phe Phe Le u Ser Le u Met 70 Val1 Leu Ile Gly Gly 150 Leu Giu Le u Leu Ph e Phe 55 Ala Leu Thr Thr Phe 135 Lys Leu Ile Ile Met Leu 40 Trp Ile Gly Le u Cys 120 Ile His Ile Pro Le u 200 Ser Ile Leu Ile Pro Gly 105 Leu Gly Arg Trp Ile 185 Val1 Val1 10 Gly Phe Leu Phe Gin 90 Val1 Leu Leu Leu Al a 170 Gi y Arg Ala Val1 Ser Gly Le u 75 Leu Ser Val1 Val1 Met 155 Asp Ile Arg Arg Ala Ser Ser Ile Asp Pro Gly Ile 140 Leu Ile Ile Met Ala Ile Asp Le u Val Ala Asp Ser 125 Pro Pro Ala Thr His 205 Gly T yr Ala Leu Ile As n Leu Val1 Le u Ser Arg 175 Leu T yr Arg Met Giu Al a Al a Se r Arg Ala Al a Al a 160 Th r Ile <213> Corynebacterium glutamicum <220> <221> CDS <222> (1117) <223> RXN03079 <400> 491 qagcggggtt gctatcggcc gaaagtttag ggttttgttc aatctgttgg ttagtattgc ttgggtaaac aagtcataac aattttcatt aagggtcgtt ttg tcg cgc aca ggt Leu Ser Arg Thr Gly 1 gtt tcg aaa aaa cca aaq ctc acc get ect. gtt gtc ate ate ggc ace Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val Val Ile Ile Gly Thr 15 etc gte ttg ttg atc ate gee ttc ace get tcc etc atg ctg ggt ccc 211 Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser Leu Met Leu Gly Pro 30 gtg acg gtt cca ttg aat gag ctt gca ace aac ccc gtt gtc acc gat 259 Vai Thr Val Pro Leu Asn Glu Leu Ala Thr Asn Pro Val Val Thr Asp 45 atc cgt gca cca ege att atc atc gca gea ttg gtg ggt gcg geg ctg 307 Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu Val Gly Ala Ala Leu 60 get gte tee ggt geg atc atg caq acg gtg ttt cac aac ccg ttg gcg 355 Ala Vai Ser Gly Ala Ile Met Gin Thr Val Phe His Asn Pro Leu Ala 75 80 gat ccc gge att gtg ggt gtg tee tee ggt gca get gtt gca get gte 403 Asp Pro Gly Ile Val Gly Val Ser Ser Gly Ala Ala Val Ala Ala Val 95 100 ttg gcg att gte ace ggt geg agt tte ttt ggc caa tgg ace gtt cet 451 Leu Ala Ile Vai Thr Gly Ala Ser Phe Phe Gly Gin Trp Thr Val Pro 105 110 115 ttt geg gee tte gtg ggc gea ttg gte aeg gtg get gtg gta tat ttg 499 Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val Ala Val Val Tyr Leu 120 125 130 ate get agt tee cge geg atg gat ggc cgt ggc gea gat ceg gee aeg 547 Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly Ala Asp Pro Ala Thr 135 140 145 ttg gta etg gte ggc atg get ate act gee ttt ttg ggt get gtt att 595 Leu Val Leu Vai Gly Met Ala Ile Thr Ala Phe Leu Gly Ala Val Ile 150 155 160 165 tc age gee act geg aae gea eca eaa gat tet gag ett ega tee gtg 643 Ser Ser Ala Thr Ala Asn Ala Pro Gin Asp Ser Giu Leu Arg Ser Val 170 175 180 acg ttt tgg etc aac gge gat etg gta tet egg aeg tgg gaa eat gtg 691 Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg Thr Trp Glu His Val 185 190 195 ggc gtt gea ata ate ccc att ate gtt ggg ttg att eta get ate gge 739 Gly Val Ala Ile Ile Pro Ile Ile Val Gly Leu Ile Leu Ala Ile Gly 200 205 210 ggt tee cgc gat ctg aae ttg ttg etg etg ggt gat tee aca geg eaa 787 Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly Asp Ser Thr Ala Gin 215 220 225 aca tet gga etc aae gte aac cge gea ege ate att ttg eta gea ctt 835 Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile Ile Leu Leu Ala Leu 230 235 240 245 gcg gea ctg etc ace gee aca get gtt geg gte tee gyc ace att aeg 883 Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val Ser Gly Thr Ile Thr 250 255 260 ttt gtt gga ttq gta gta ccc cac ctg gtg cgc att gtt tta ggt gcc 931 Phe Val Gly Leu Val Val Pro His Leu Val Arg Ile Val Leu Gly Ala 265 270 275 gat cac cga gcg tta ctc ccg gcc gcc gcg att ttg ggc gcc acg ttt 979 Asp His Arg Ala Leu Leu Pro Ala Ala Ala Ile Leu Gly Ala Thr Phe 280 285 290 gtt atc gtt tcc gac act gtt gcc cgc. atg atc ttc tcc ccc atc qtc 1027 Val Ile Val Ser Asp Thr Val Ala Arg Met Ile Phe Ser Pro Ile Val 295 300 305 ttg caa aca qgc gtg gtg gtg gcg ttc att ggc tca cca att ttc ctt 1075 Leu Gin Thr Gly Val Val Val Ala Phe Ile Gly Ser Pro Ile Phe Leu 310 315 320 325 tat tta ctg ctc agc atg cgc aag cga cgc gga ttg ggg ctg 1117 Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly Leu Gly Leu 330 335 taaaaactca tgcctcaatt agt 1140 <210> 492 <211> 339 <212> PRT <213> Corynebacterium glutamicum <400> 492 Leu Ser Arg Thr Gly Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val 1 5 10 Val Ile Ile Gly Thr Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser 25 Leu Met Leu Gly Pro Val Thr Val Pro Leu Asn Giu Leu Ala Thr Asn 40 Pro Val Val Thr Asp Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu 55 Val Gly Ala Ala Leu Ala Val Ser Gly Ala Ile Met Gin Thr Val Phe 70 75 His Asn Pro Leu Ala Asp Pro Gly Ile Val Gly Vai Ser Ser Gly Ala 90 Ala Val Ala Ala Val Leu Ala Ile Val Thr Gly Ala Ser Phe Phe Gly 100 105 110 Gin Trp Thr Val Pro Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val 115 120 125 Ala Val Val Tyr Leu Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly 130 135 140 Ala Asp Pro Ala Thr Leu Val Leu Val Gly Met Ala Ile Thr Ala Phe 145 150 155 160 Len Gly Ala Val Ile Ser Ser Ala Thr Ala Asn Ala Pro Gin Asp Ser 165 170 175 Giu Len Arq Ser Val Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg 180 185 190 Thr Trp Gin His Val Gly Val Ala Ile Ile Pro Ile Ile Val Gly Len 195 200 205 Ile Leu Ala Ile Giy Gly Ser Arg Asp Leu Asn Len Len Len Leu Gly 210 215 220 Asp Ser Thr Ala Gin Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile 225 230 235 240 Ile Leu Leu Ala Leu Ala Ala Len Len Thr Ala Thr Ala Val Ala Val 245 250 255 Ser Gly Thr Ile Thr Phe Val Gly Leu Val Val Pro His Len Val Arg 260 265 270 Ile Val Len Gly Ala Asp His Arg Ala Len Len Pro Ala Ala Ala Ilie 275 280 285 Leu Gly Ala Thr Phe Val Ilie Val Ser Asp Thr Val Ala Arg Met Ilie 290 295 300 Phe Ser Pro Ile Val Leu Gin Thr Giy Val Val Val Ala Phe Ile Gly 305 310 315 320 Ser Pro Ilie Phe Len Tyr Leu Leu Len Ser Met Arg Lys Arg Arg Gly 325 330 335 Len Gly Len <210> 493 <211> 1140 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(1117) <223> FRXA02865 <400> 493 gagcggggtt qctatcggcc qaaagtttaq ggttttgttc aatctgttgg ttagtattgc ttgggtaaac aagtcataac aattttcatt aagggtcgtt ttg tcq cgc aca ggt 115 Len Ser Arg Thr Gly 1 gtt tcg aaa aaa cca aag ctc acc gct cct gtt gtc ate atc ggc acc 163 Val Ser Lys Lys Pro Lys Len Thr Ala Pro Val Vai Ile Ile Gly Thr 15 etc gtc ttg ttg ate atc gcc ttc ace gct tee etc atg ctg ggt ccc 211 Len Val Len Len Ile Ile Ala Phe Thr Ala Ser Len Met Len Gly Pro 30 gtq acq gtt Val Thr Val cca ttg aat gag Pro Leu Asn Giu gca acc aac ccc Ala Thr Asn Pro gtc acc gat Val Thr Asp atc cgt Ile Arg gca cca cqc att Ala Pro Arg Ile atc Ile 60 atc gca qca ttq Ile Ala Ala Leu qt g Val1 ggt gcg gcg ctg Gly Ala Ala Leu gc t Al a gtc tcc qgt gcg Val Ser Gly Ala atg cag acg gtq Met Gin Thr Val ttt Phe cac aac ccg ttg His Asn Pro Leu gat ccc ggc att Asp Pro Gly Ile gtg ValI ggt gtg tcc tcc Gly Val Ser Ser gca gct gtt gca Ala Ala Val Ala gct gtc Ala Val 100 ttg gcg att Leu Ala Ile ttt gcg gcc Phe Ala Ala 120 acc ggt gcg agt Thr Gly Ala Ser ttt ggc caa tgg Phe Gly Gin Trp acc qtt cct Thr Val Pro 115 gta tat ttg Val Tyr Leu ttc gtg ggc gca Phe Vai Gly Ala ttg Le u 125 gtc acg gtg gct Val Thr Val Ala atc gct Ile Ala 135 agt tcc cgc gcg Ser Ser Arg Ala gat gqc cgt ggc Asp Gly Arg Gly gat ccg gcc acg Asp Pro Ala Thr gta ctg gtc ggc Val Leu Val Giy gct atc act gcc Ala Ile Thr Ala ttt Phe 160 ttg ggt gct gtt Leu Giy Ala Val tcc agc gcc act Ser Ser Ala Thr gcq Al a 170 aac gca cca caa Asn Ala Pro Gin tct gag ctt cga Ser Giu Leu Arg tcc gtq Ser Val 180 acg ttt tgg Thr Phe Trp ggc qtt gca Gly Vai Ala 200 ctc Le u 185 aac ggc gat ctg Asn Gly Asp Leu gta Val1 190 tct cgg acg tgg Ser Arg Thr Trp gaa cat gtg Glu His Val 195 gct atc ggc Ala Ile Gly ata atc ccc att Ile Ile Pro Ile gtt ggg ttg att Val Gly Leu Ile ggt tcc Gly Ser 215 cgc gat ctg aac Arg Asp Leu Asn ttg Leu 220 ttg ctg ctg ggt Leu Leu Leu Gly tcc aca gcg caa Ser Thr Ala Gin tct gga ctc aac Ser Gly Leu Asn aac cgc gca cgc Asn Arg Ala Arg atc Ile 240 att ttg cta gca Ile Leu Leu Ala ct t Leu 245 gcg gca cig ctc Ala Ala Leu Leu gcc aca gct gtt Ala Thr Ala Val gcg Ala 255 gtc tcc ggc acc Val Ser Gly Thr att acg Ile Thr 260 ttt qtt gqa Phe Val Gly ttg Le u 265 qta gta ccc cac Val Val Pro His ctg Leu 270 gtg cgc att gtt Val Arg Ile Val tta ggt gcc Leu Gly Ala 275 gat cac cga gcq tta Ctc ccg gcc gcc gcg Asp His Arg Ala Leu Leu Pro Ala Ala Ala 280 285 gtt atc gtt tcc gac act gtt gcc cgc atg Val Ile Val Ser Asp Thr Val Ala Arg Met 295 300 ttg caa aca ggc gtg gtg gtg gcg ttc att Leu Gln Thr Gly Val Val Val Ala Phe Ile 310 315 tat tta ctg ctc agc atg cgc aaq cga cgc Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg 330 335 taaaaactca tqcctcaatt agt <210> 494 <211> 339 <212> PRT <213> Corynebacterium glutamicum at t Ile atc Ile Gly 320 gqa Gly ttg ggc gcc acg ttt Leu Gly Ala Thr Phe 290 ttc tcc ccc atc gtc Phe Ser Pro Ile Val 305 tca cca att ttc ctt Ser Pro Ile Phe Leu 325 ttg ggg ctg Leu Gly Leu 979 1027 1075 1117 1140 <400> 494 Leu Vai Leu Pro Vai His Ala Gin Ala Ala 145 Leu Glu Ser Ile Met Val1 Gi y As n Val Trp Val1 130 Asp Gly Leu Arg Thr Ile Gly Leu Gly Val Thr Ala Ala Pro Leu Ala Ala 100 Thr Val 115 Val Tyr Pro Aia Ala Val Arg Ser 180 Gly Thr Pro Asp Le u Al a Val1 Pro Le u Thr Ile 165 Val1 Val Ser Lys Lys Le u Val1 Ile Al a 70 Asp Leu Phe Ile Leu 150 Ser Thr Val1 Thr Arg 55 Val1 Pro Ala Ala Ala 135 Val Ser Phe be u Val1 40 Ala Se r Gly Ile Al a 120 Se r be u Ala Trp Leu Pro Pro Gly Ile Val1 105 Phe Ser Val1 Thr Leu 185 Pro Ile Le u Arg Ala Val1 90 Thr Val1 Arg Gly Ala 170 Asn Lys Ile As n Ile Ile 75 Gly Gly Gly Ala Met 155 Asn Gly Leu Ala Glu Ile Met Val1 Al a Ala Met 140 Al a Ala Asp Th r Phe Leu Ile Gin Ser Ser Leu 125 Asp Ile Pro Le u Pro Ala Thr Al a ValI Gly Phe Thr Arg Ala Asp 175 Se r ValI Se r Asn Le u Ph e Al a Gly Val1 Gly Phe 160 Ser Arg Thr Ile Asp 225 Ile Ser Ile Leu Phe 305 Ser Leu Trp Len 210 Ser Leu Gly Va1 Gly 290 Ser Pro Gly Glu 195 Ala Thr Leu Thr Leu 275 Ala Pro Ile Leu Va1 Gly Gin Leu 245 Thr Ala Phe Va1 Leu 325 Gly Gly Thr 230 Ala Phe Asp Va1 Leu 310 Tyr Val Ser 215 Ser Ala Va1 His Ile 295 Gin Leu Ala 200 Arg Gly Leu Gly Arg 280 Val Thr Leu Ile Asp Len Len Len 265 Ala Ser Gly Leu Ile Leu Asn Thr 250 Va1 Leu Asp Va1 Ser 330 Pro Asn Va1 235 Ala Va1 Leu Thr Va1 315 Met Ile Leu 220 Asn Thr Pro Pro Va1 300 Va1 Arg Ile 205 Leu Arg Ala His Ala 285 Ala Ala Lys Va1 Leu Ala Va1 Leu 270 Ala Arg Phe Arg Gly Len Arg Ala 255 Val Ala Met Ile Arg 335 <210> 495 <211> 1695 <212> DNA <213> Corynebacterium giutamioum <220> <221> CDS <222> (101)..(1672) <223> RXA00181 <400> 495 gtatattcag acacccacqt cgattagtgt tgtagttoac atctttgoac gtttgtcccc tacccaaaag gagaaacctc tgg ttc atc ata goc atc gtt ato tat Trp Phe Ile Ile Ala Ile Val Ile Tyr ggc tat tgg agt tao cgo aag aca gaa Gly Tyr Trp Ser Tyr Arg Lys Thr Glu 30 goc gg cgc ggg ctc aac cct ttt gtt Ala Gly Arg Gly Leu Asn Pro Phe Val 45 tca gat atg tca gqt tgg ctg ctc atg atg ttg Met Leu 15 aaa tac Lys Tyr 9CC gca Ala Ala ggt ctg agtgcttatt ttttatttgt atg ago gat aac aoo Met Ser Asp Asn Thr 1 gtg atg gtg ctc atc Val Met Val Leu Ile gao gao tac atg ctc Asp Asp Tyr Met Len atg too gca ggt goc Met Ser Ala Gly Ala cc ggo gog otg ttt 115 163 211 259 307 Ser Asp Met Ser Gly Trp Le u Leu Met Gly Leu Gly Ala Leu Phe gtc Val1 acc qgc atg tcc Thr Gly Met Ser ttg tgq atc gca Leu Trp Ile Ala gt c Val1 80 gqa ctc acc att Gly Leu Thr Ile ggt Gly gca tqg gcg aac Ala Trp Ala Asn tgg Trp atg tgg gtg gca Met Trp Val Ala cgt ctt cgt tct Arg Leu Arg Ser tat tcc Tyr Ser 100 gaa atc tcg Glu Ile Ser ctt cgc gat Leu Arg Asp 120 aac tca atc acc Asn Ser Ile Thr cct tca ttc ttt Pro Ser Phe Phe gag aac cga Glu Asn Arg 115 cta att atc Leu Ile Ile aaa tct cgc gcg Lys Ser Arg Ala cgc atc att gca Arg Ile Ile Ala att gtg Ile Val 135 ttc ttc acc ttc Phe Phe Thr Phe tac Tyr 140 att tct tca ggc Ile Ser Ser Gly gtt gct ggt gga Val Ala Gly Gly gtg Val1 150 tat tgg gag tc Tyr Trp Glu Ser ttt ggt gga gat Phe Gly Gly Asp tat Tyr 160 cta ctc ggt aig Leu Leu Gly Met gcc Al a 165 att qtc gca ggt Ile Val Ala Gly gtg Val1 170 aca qtg ctq tat Thr Val Leu Tyr ttc att gga gga Phe Ile Gly Gly ttc ctt Phe Leu 180 gct gtg tct Ala Val Ser ttg atc atc Leu Ile Ile 200 aca qac gca gtt Thr Asp Ala Val ggg act atc atg Gly Thr Ile Met ttc ttc tcg Phe Phe Ser 195 aac ccc atg Asn Pro Met gtg cca gtc atg Val Pro Val Met gca Ala- 205 tat ttc gca Ctg Tyr Phe Ala Leu gcg Ala 210 gat att Asp Ile 215 tgg agc ttt gca Trp Ser Phe Ala aac Asn 220 tct aat gat tac Ser Asn Asp Tyr ccg cac acc gat Pro His Thr Asp att ggc aat ccc Ile Gly Asn Pro a cc Thr 235 tac ttc tcc atg Tyr Phe Ser Met agt ggc att tct Ser Gly Ile Ser gca gca atc att Ala Ala Ile Ile ggt Gly 250 aac tta ggt tgg Asn Leu Gly Trp gg t Gly 255 ctt gga tac ttc Leu Gly Tyr Phe ggc cag Gly Gin 260 cca cac att Pro His Ile aag caa ggt Lys Gin Gly 280 gtt cgt ttc atg Vai Arg Phe Met ctt cgc aca cca Leu Arg Thr Pro gct gaa gca Ala Giu Ala 275 tgc ctg att Cys Leu Ile cgt cgc atc ggt Arg Arg Ile Gly tcc tgg atg ata Ser Trp Met Ile ggt gca acc ttt acc gca att atc tcc Gly Ala Thr Phe Thr Ala Ile Ile Ser aca gtt ttc ttt gca caa aac Thr Val Phe Phe Ala Gin Asn 1027 300 305 ccc Pro 310 gac gCC aao atc Asp Ala Asn Ile act Th r 31S gao aca agg gct Asp Thr Arg Ala tat Tyr 320 gag tcc atc ttc Glu Ser Ile Phe 1075 1123 gat ctt gcc cgg Asp Leu Ala Arg ctg ttc cac cca. Leu Phe His Pro atc gct gga ctt Ile Ala Gly Leu att ctg Ile Len 340 act qot gtt Thr Ala Val gtc aco goa Val Thr Ala 360 ctc Leu 345 gcg gcc atc atq Ala Ala Ile Met tct' Ser 350 acc atg tog tca Thr Met Ser Ser cag otg otg Gin Leu Leu 355 gtt aaa aag Val Lys Lys 1171 1219 tot toc ctg att Ser Ser Len le gac ctg ctg aag Asp Len Leu Lys gao tcg Asp Ser 375 otg agc gaa cgc Leu Ser Gin Arg ctg ato atg ctg Leu Ile Met Len ogt gcc aca. gtc Arg Ala Thr Val atc Ile 390 att. ctg gcg atc Ile Len Ala Ile att Ile 395 qca gca gco atg Ala Ala Ala Met got Ala 400 att aac cog tct Ile Asn Pro Ser tcc atc ctc gqa Ser Ile Leu Gly gtq gqa ttt gcq Val Gly Phe Ala tgg Trp 415 gca gga ttc go Ala Gly Phe Gly tct gca Ser Ala 420 1267 1315 1363 1411 1459 ttt ggt ccg Phe Gly Pro g00 ggc got Ala Gly Ala 440 ata ctt got ago Ile Len Ala Ser Ott Len 430 tat tgg aag ogt Tyr Trp Lys Arg ctc aac 900 Len Asri Ala 435 too atc gog Ser Ile Ala ato too ggo atg Ile Ser Giy Met att Ile 445 act gqt got att Thr Gly Ala Ile gto Val1 450 tgg ggt Trp Gly 455 atg too cca cta Met Ser Pro Len gat acg ttg tat Asp Thr Leu Tyr gaa Gin 465 ato ato oca ggt Ile Ile Pro Gly goc ttg gca aoo Ala Len Ala Thr gtg atg gtc gtt Val Met Val Val too oto otg aca Ser Len Len Thr 1507 1555 1603 1651 gaa ccc too gaa. Glu Pro Ser Gin atc oto aac gag Ile Len Asn Gin gaa aoc 900 aag Giu Thr Ala Lys gat ott Asp Leu 500 got goc got Ala Ala Ala oag aag ott Gin Lys Len 520 <210> 496 <211> 524 gtg Val1 505 gaa tca aao gag Gin Ser Asn Gin ga t Asp 510 gtt gat tto got Val Asp Phe Ala gao goa got Asp Ala Ala 515 tog aaa gaa agt Ser Lys Gin Ser taagoottag agggaaccaa aog 1695 <212> PRT <213> Corynebacterium glutamicum <400> 496 Met Ser Asp Asn Thr Trp Phe Ile Ile Ala Ile Val Ile Tyr Met Leu 1 5 10 Val Met Val Leu Ile Gly Tyr Trp Ser Tyr Arg Lys Thr Glu Lys Tyr 25 Asp Asp Tyr Met Leu Ala Gly Arg Gly Leu Asn Pro Phe Val Ala Ala 40 Met Ser Ala Gly Ala Ser Asp Met Ser Gly Trp Leu Leu Met Gly Leu 55 Pro Gly Ala Leu Phe Val Thr Gly Met Ser Glu Leu Trp Ile Ala Val 70 75 Gly Leu Thr Ile Gly Ala Trp Ala Asn Trp Met Trp Val Ala Pro Arg 90 Leu Arg Ser Tyr Ser Glu Ile Ser Ala Asn Ser Ile Thr Leu Pro Ser 100 105 110 Phe Phe Glu Asn Arg Leu Arg Asp Lys Ser Arg Ala Leu Arg Ile Ile 115 120 125 Ala Ala Leu Ile Ile Ile Val Phe Phe Thr Phe Tyr Ile Ser Ser Gly 130 135 140 Met Val Ala Gly Gly Val Tyr Trp Glu Ser Thr Phe Gly Gly Asp Tyr 145 150 155 160 Leu Leu Gly Met Ala Ile Val Ala Gly Val Thr Val Leu Tyr Thr Phe 165 170 175 Ile Gly Gly Phe Leu Ala Val Ser Tyr Thr Asp Ala Val Gin Gly Thr 180 185 190 Ile Met Phe Phe Ser Leu Ile Ile Val Pro Val Met Ala Tyr Phe Ala 195 200 205 Leu Ala Asn Pro Met Asp Ile Trp Ser Phe Ala Asn Ser Asn Asp Tyr 210 215 220 Gly Pro His Thr Asp Gly Ile Gly Asn Pro Thr Tyr Phe Ser Met Ile 225 230 235 240 Ser Gly Ile Ser Ala Ala Ala Ile Ile Gly Asn Leu Gly Trp Gly Leu 245 250 255 Gly Tyr Phe Gly Gin Pro His Ile Val Val Arg Phe Met Ala Leu Arg 260 265 270 Thr Pro Ala Glu Ala Lys Gin Gly Arg Arg Ile Gly Ile Ser Trp Met 275 280 285 Ile Ile Cys Leu Ile Gly Ala Thr Phe Thr Ala Ile Ile Ser Thr Val 290 295 300 Phe Phe Ala Gin Asn Pro Asp Ala Asn Ile Thr Asp Thr Arg Ala Tyr 305 310 315 320 Giu Ser Ile Phe Leu Asp Leu Ala Arg Met Leu Phe His Pro Leu Ile 325 330 335 Ala Gly Leu Ile Leu Thr Ala Val Leu Ala Ala Ile Met Ser Thr Met 340 345 350 Ser Ser Gin Leu Leu Val Thr Ala Ser Ser Leu Ile Glu Asp Leu Leu 355 360 365 Lys Val Vai Lys Lys Asp Ser Leu Ser Giu Arg Thr Leu Ile Met Leu 370 375 380 Ser Arq Ala Thr Val Ile Ile Leu Ala Ile Ile Ala Ala Ala Met Ala 385 390 395 400 Ile Asn Pro Ser Asp Ser Ile Leu Gly Leu Val Gly Phe Ala Trp Ala 405 410 415 Gly Phe Gly Ser Ala Phe Giy Pro Ile Ile Leu Ala Ser Leu Tyr Trp 420 425 430 Lys Arg Leu Asn Ala Ala Gly Ala Ile Ser Gly Met Ile Thr Gly Ala 435 440 445 Ile Val Ser Ile Ala Trp Gly Met Ser Pro Leu Ser Asp Thr Leu Tyr 450 455 460 Giu Ile Ile Pro Gly Phe Ala Leu Ala Thr Ile Val Met Val Val Val 465 470 475 400 Ser Leu Leu Thr Lys Giu Pro Ser Glu Giu Ile Leu Asn Giu Phe Glu 485 490 495 Thr Ala Lys Asp Leu Ala Ala Ala Val Giu Ser Asn Glu Asp Val Asp 500 505 510 Phe Ala Asp Ala Ala Gin Lys Leu Ser Lys Giu Ser 515 520 <210> 497 <211> 1476 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1453) <223> RXA00591 <400> 497 gcaacgccac aggcaaaatc caaaagaaca tcctgcgaga cttcaccatc cccgtttcat aaacccccca. acqtcacttt gaaaacactt qgagaacgca atg act aca tct too: 115 Met Thr Thr Ser Ser 1 aca qct tog ccg ato got gaa tta caa aao ctc agc ccg aag caa aga 163 Thr Ala Ser Pro Thr Aa Se Pro Ala Glu Leu Gin LeSrPrLy Leu Ser Pro Lys Gin Arg aaa tea gaa Lys Ser Giu ate gag ttc Ile Glu Phe tcc Ser egg ege geg att Arg Arg Ala Ile ata Ile 30 tee age tac ttg Ser Ser Tyr Leu ggc tcc aeg Gly Ser Thr gcg acg gta. Ala Thr Val tat gac ttc ctg Tyr Asp Phe Leu tat gcc gca gcc Tyr Ala Ala Ala tce Ser ttc ccc Phe Pro qca gtg ttc ttt Ala Val Phe Phe ace T hr aat etc gat ccg Asn Leu Asp Pro get gga acc att Ala Gly Thr Ile gcc Ala gcc tac qga acc Ala Tyr Gly Thr gcc gca ggt tat Ala Ala Gly Tyr get agg cca. ctt Ala Arg Pro Leu gga gca atc ttc Gly Ala Ile Phe gga Gly cac ttc ggt gac His Phe Gly Asp ctt gga cgc aag Leu Gly Arg Lys aag atg Lys Met 100 ctt gtg ttg Leu Val Leu ctt gte cca Leu Val Pro 120 atg cte ate atg Met Leu Ile Met qgt Gly 110 gtg gca tcc aca Val Ala Ser Thr tgc atc ggc Cys Ile Gly 115 gta atc ctg Val Ile Leu agc get gaa atg Ser Ala Giu Met atc Ile 125 gga agc atq gqc Gly Ser Met Gly gcg Ala 130 ate atg Ile Met 135 ctg cgc ate tgc Leu Arg Ile Cys caa Gin 140 ggc ate gct gtc Gly Ile Ala Val ggc gaa tqg ggc Gly Giu Trp Gly get gee etc atg Ala Ala Leu Met etc gag cac tea Leu Glu His Ser tee aag aag egc Ser Lys Lys Arg 547 595 643 ttc gcc gcc tee Phe Ala Ala Ser ttc Phe 170 acc aac get ggt Thr Asn Ala Gly eca ace ggc get Pro Thr Gly Ala yea etg Ala Leu 180 gga acc ttc Gly Thr Phe ttc ctt tea Phe Leu Ser 200 geg Ala 185 etc ggt ace gca Leu Gly Thr Ala t et Ser 190 get gtt etc ace Ala Val Leu Thr cag gag caa Gin Giu Gin 195 ttc gtt etg Phe Val Leu tgg ggt tgg ege Trp Gly Trp Arg cca tte etg ete Pro Phe Leu Leu tct Ser 210 ety att Leu Ile 215 gte ggc ttg gtt Val Gly Leu Val ate Ile 220 ego geg aaa gtt Arg Ala Lys Val age Ser 225 gaa tea. eea etg Giu Ser Pro Leu gea get gca gog Ala Ala Ala Ala gee gaa aaa gee Ala Glu Lys Ala eea ace gaa egt Pro Thr Giu Arg aaa. Lys 245 gte ccc ete ttg eag gtt ctt ege ega eea. aag gca etg ate ttg ace Val Pro Leu Leu Gin Val Leu Arg Arg Pro Lys Ala Leu Ile Leu Thr 255 atg ctt ggc Met Leu Gly ttc tcc atc Phe Ser Ile 280 gge Giy 265 gca tea gga ttc Ala Ser Gly Phe ctt caa gtt etc Leu Gin Val Leu ttg tce ace Leu Ser Thr 275 tcc agc gtc Ser Ser Val agc tac gca aca Ser Tyr Ala Thr tcc ggc atc gaa Ser Gly Ile Giu ctc tac Leu Tyr 295 gcc ttc gca gtc Ala Phe Ala Val gee Al a 300 tca gtg ttc tct Ser Val Phe Ser gte ttc ttt gtq Val Phe Phe Val 305 cga ccc gtc atq Arg Pro Val Met ate Ile ate Ile 325 ttc ggt cgc gta Phe Gly Arg Val gac ctc ttc gga Asp Leu Phe Gly 1027 1075 1123 ate gcg ctc gta Ile Ala Leu Val ttc gtg gee tac Phe Val Ala Tyr ctg Le u 335 eeg gea tte tte Pro Ala Phe Phe egg atg Arg Met 340 etc ace tea Leu Thr Ser etc qca etc Leu Ala Leu 360 ga e Asp 345 aae tgg tte ate Asn Trp Phe Ile etc teg gea tte Leu Ser Ala Phe ace ate geg Thr Ile Ala 355 ttt ate tee Phe Ile Ser 1171 1219 eac gee atg ctt His Ala Met Leu gge eca eta gca Gly Pro Leu Ala qeg Ala 370 gaa caa Giu Gln 375 ttc gga ace tee Phe Gly Thr Ser 9eg Al a 380 ego tac aca ggc Arg Tyr Thr Gly gea Ala 385 toe ctg ggt tac Ser Leu Gly Tyr ttg gee aeg etc Leu Ala Thr Leu ate Ile 395 ggt gea gga tte Gly Ala Gly Phe eca ace ate etg Pro Thr Ile Leu 1267 1315 1363 age etc tao geg Ser Leu Tyr Ala eca gge gge gga Pro Gly Gly Gly tet gte ace eca Ser Val Thr Pro gte ate Val Ile 420 gte tte etc Val Phe Leu ace aga gaa Thr Arq Glu 440 gea Al a 425 aeg atg tee eta Thr Met Ser Leu gtq Val1 430 tee ate ate gee Ser Ile Ile Ala ate gca ate Ile Ala Ile 435 1411 tea aaa gae cae Ser Lys Asp His ett tet act tac Leu Ser Thr Tyr gaa cac Giu His 450 1453 taaggggaeg atagggteaa ttt <z210> 498 <211>' 451 <212> PRT <213> Corynebacterium glutamicum <400> 498 Met Thr Thr Ser Ser Thr Ala Ser Pro Ile 1 5 10 1476 Ala Glu Leu Gin Asn Leu Ser Pro Lys Gin Arg Lys Ser Glu Ser Arg Arg Ala Ile 25 Ile Ser Ser Tyr Ala Leu Ala Gly Ser Gly Gly 145 Ser Thr Leu Leu Ser 225 Pro Ala Val Glu Val 305 Arg Leu Gly Ser Ala Ala Gly Arg Pro Arg Lys Thr Cys 115 Ala Val 130 Gly Glu Lys Lys Gly Ala Thr Gin 195 Ser Phe 210 Glu Ser Thr Glu Leu Ile Leu Leu 275 Arg Ser 290 Phe Phe Pro Val Ser Thr Thr Leu Lys 100 Ile Ile Trp Arg Ala 180 Glu Val Pro Arg Leu 260 Ser Ser Val Met Thr Val Ile Gly Met Gly Leu Gly Gly 165 Leu Gin Leu Leu Lys 245 Thr Thr Val Ile Ile 325 Ile Phe Ala 70 Gly Leu Leu Ile Gly 150 Phe Gly Phe Leu Phe 230 Val Met Phe Leu Leu 310 Ile Glu Pro 55 Ala Ala Val Val Met 135 Ala Ala Thr Leu Ile 215 Ala Pro Leu Ser Tyr 295 Phe Ala Phe 40 Ala Tyr Ile Leu Pro 120 Leu Ala Ala Phe Ser 200 Val Ala Leu Gly Ile 280 Ala Gly Leu Tyr Val Gly Phe Ser 105 Ser Arg Leu Ser Ala 185 Trp Gly Ala Leu Gly 265 Ser Phe Arg Val Asp Phe Thr Gly 90 Met Ala Ile Met Phe 170 Leu Gly Leu Ala Gin 250 Ala Tyr Ala Val Leu 330 Phe Leu Phe Thr Phe Ala 75 His Phe Leu Ile Glu Met Cys Gin 140 Ala Leu 155 Thr Asn Gly Thr Trp Arg Val Ile 220 Ala Ala 235 Val Leu Ser Gly Ala Thr Val Ala 300 Ser Asp 315 Phe Val Leu Tyr Asn Leu Ala Gly Gly Asp Met Gly 110 Ile Gly 125 Gly Ile Glu His Ala Gly Ala Ser 190 Ile Pro 205 Arg Ala Glu Lys Arg Arg Phe Gly 270 Gin Ser 285 Ser Val Leu Phe Ala Tyr Ala Ala Asp Pro Tyr Leu Arg Leu Val Ala Ser Met Ala Val Ser Asp 160 Ala Pro 175 Ala Val Phe Leu Lys Val Ala Lys 240 Pro Lys 255 Leu Gin Gly Ile Phe Ser Gly Arg 320 Leu Pro 335 Ala Phe Phe Arg Met Leu Thr Ser Asp Asn Trp 340 345 Ala Phe Thr Ile Ala Leu Ala Leu His Ala Met 355 360 Ala Ala Phe Ile Ser Giu Gin Phe Gly Thr Ser 370 375 Ala Ser Leu Gly Tyr Gin Leu Ala Thr Leu Ile 385 390 395 Pro Thr Ile Leu Ala Ser Leu Tyr Ala Gly Pro 405 410 Val Thr Pro Val Ile Val Phe Leu Ala Thr.Met 420 425 Ile Ala Ile Ala Ilie Thr Arg Giu Ser Lys Asp 435 440 Tyr Giu His 450 <210> 499 <211> 1635 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(1612) <223> RXA01629 <400> 499 caqgaagaag ttaacaccqc ccaqqqgtqc gttggatqat tccgttatgc actcataaga tatgacgaga ggttttactc Leu 350 Gi y Tyr Gly Gly Val1 430 Le u Ser Le u Gly Th r 400 Ser Ile Thr tca Se r aac As n gtg Val1 acg Thr cag Gin aaa. Lys gt t Val1 gg t Gly gt c Val1 ttg Leu aag Lys gtt Val1 aac Asn a cg Thr ttg Leu aaa Lys ccc Pro ttc Phe atg Met gcc Ala aag Lys aag Lys gag Giu gca Al a atg Met 75 aac As n aag Lys tgg Trp gta Val1 60 ttt Phe gaa Giu atc Ile tac Tyr 45 ttt Phe ggt Gly cca Pro cg t Arg 30 gac Asp acc Thr ttc Phe aga Arg c cq Pro ttc Phe caa Gin g cg Ala ct a Leu gcc Ala gga Gi y Gly gtg Val1 80 gatcatctac aaacaaacat gtg agc ccg att cqc Val Ser Pro Ile Arg 1 aca gtc gat gac gtc Thr Val Asp Asp Val att aaa qgc act qtg Ile Lys Gly Thr Val att tat ggt tat ttg Ile Tyr Gly Tyr Leu ctg ccg caa gaa tgg Leu Pro Gin Giu Trp tct tat tta gtt cgc Ser Tyr Leu Val 'Arg 115 163 211 259 307 355 cgq ctt ggt ggc Pro Leu Gly Gly ctg Leu gtt ctgj 9gt ccg Val Leu Gly Pro ct t Leu 95 ggc gat aag gtt Gly Asp Lys Val ggC cgc Gly Arg 100 cag aag gtt Gin Lys Val ctg att ggc Leu Ile Gly 120 tac gta acc atg Tyr Val Thr Met gcc Ala 110 atg atg gcc gtg Met Met Ala Val tct acg gcg Ser Thr Ala 115 tgg got ttg Trp Ala Leu ttg ctg cog acg Leu Leu Pro Thr gcg tog ata ggc Ala Ser Ile Gly gtg ctt Val Leu 135 ttg tao ctg ttg Leu Tyr Leu Leu atg gtg Gag gga Met Val Gin Gly tog act ggt ggt Ser Thr Gly Gly gaa Giu 150 tat got ggt gog Tyr Ala Gly Ala acc Thr 155 aco tat gtt got Thr Tyr Val Ala gag Giu 160 ttt gog cog gat Phe Ala Pro Asp cga cga ggt ttc Arg Arg Gly Phe gga got ttc ota Gly Ala Phe Leu atg ggt tcc tao Met Gly Ser Tyr ctg ggc Leu Gly 180 ttt gc qcg Phe Ala Ala cac tto tat His Phe Tyr 200 got tog gto qtg Ala Ser Val Val gcg Ala 190 att act aco tgg Ile Thr Thr Trp gtg aco act Val Thr Thr 195 ogt att cot Arg Ile Pro ggo gca act gc Gly Ala Thr Ala gag gat ttc ggt Giu Asp Phe Gly ttc ctg Phe Leu 215 act gog atc cog Thr Ala Ile Pro ggc ato att gog Gly Ile Ile Ala tao otg cgt act Tyr Leu Arg Thr ogt Arg 230 ato cot gag aco Ile Pro Glu Thr Oct Pro 235 gog ttt gag aac Ala Phe Glu Asn aao As n 240 caa gao gag cca Gin Asp Glu Pro aat As n 245 gca gtt qtt gaa Ala Val Val Giu gao act qaa gat Asp Thr Glu Asp oct Pro 255 tat goa ogo otg Tyr Ala Arg Leu gqc ctg Gly Leu 260 got ggt gtt Ala Gly Val att gtg gca Ile Val Ala 280 ogo cac cac tgg Arg His His Trp ogt Arq 270 cca ctg otq att Pro Leu Leu Ile ggt att gog Gly Ile Ala 275 agt tao atg Ser Tyr Met 931 979 qog aco aac aco Ala Thr Asn Thr gc Ala 285 ggt tao gog ota Gly Tyr Ala Leu acc Thr 290 cot gtg Pro Val 295 tat ota gag gag Tyr Leu Giu Glu ato ggt otg cac Ile Gly Leu His gca too got gc Ala Ser Ala Ala 1027 10'75 got Ala 310 gtg aco gtg cog Val Thr Val Pro ctg gtt gtt atg Leu Val Val Met ctg ctg otg cca Leu Leu Leu Pro ttt Ph e 325 gtt ggt atg tgg agt Val Gly Met Trp Ser 330 gct Ala aac As n att Ile ct g Le u 390 att Ilie ctg Le u ttc Phe t ca Se r gag Glu 470 ct t Leu caa Gin gt t Val1 acc Th r cca Pro 375 ttc Phe t cc Se r ct g Le u ttc Phe cag Gin 455 gc c Al a tcc Se r aac As n qcq gca acg Ala Ala Thr 345 gga acc atc Gly Thr Ile 360 acc ggt ttg Thr Giy Leu cca acc gcg Pro Thr Ala gtg tcg ttg Val Ser Leu 410 cag aag act Gin Lys Thr 425 tct gca atc Ser Ala Ile 440 aag cca ctg Lys Pro Leu gtg gag atc Val Giu Ile cat atg ccg His Met Pro 490 gca taaccgt~ Ala ga c Asp ctg Leu ggc Gly tat Tyr t ca Se r 395 ttc Phe ggc Gly qca Ala ct t Leu gtg Val 475 ttt Arg Val Gly cgc gtg ggc cgc aag cct gtc tac gcg act 1123 Lys Pro Val Tyr Ala Thr 340 ttg Leu gt a Val1 365 gca Ala ttc Phe ggt Gi y ga t Asp gtg Val1 445 t ca Ser aac Asn gat atg Met 350 ct g Le u ctg Leu tct Ser aca Thr at c Ile 430 gcg Al a ttc Phe ca g Gin gag gt t Val1 att Ile t cc Se r gga Gly aco Thr 415 gt t Val ctg Le u cca Pro gac Asp ga a cc t Pro gca Al a gca Al a atg Met 400 cg Pro cca Pro ctg Leu acc Thr gag G lu 480 aac Asn gc Ala ctg Leu tct Ser 385 ggt Gly ctg Leu gog Ala ttc Phe gtg ValI 465 ga t Asp gta Val1 t tc Phe t cc Ser 370 gcc Ala att Ile atc Ile ctc Leu atg Met 450 gaa Glu cca Pro ggt Gly ttg Le u 355 atg Met ctg Leu t cc Ser acc Thr tac Tyr 435 aco Thr acc Thr aat Asn got Ala ato Ile gt t Val oca Pro t ac Tyr ca g Gin 420 atc Ile gag Glu aag Lys att Ile gaa Glu 500 atg Met gct Al a gcg Al a aac Asn 405 ttc Phe atg Met tct Ser tot Se r gat Asp 485 aag Lys 1171 1219 1267 1315 1363 1411 1459 1507 1555 1603 Phe Pro Asp Glu Glu 495 aaa gooogctgoa agg 1635 <210> 500 <211> 504 <212>' PRT <c213> Corynebacterium giutamioum <400> 500 Val Ser Pro Ile Arg Ser Lys Lys Lys Ile Lys Asn Glu Pro Arg Leu 1 5 10 Thr Val Asp Asp Val Asn Val Val Pro Pro Lys Lys Ile Arg Pro Ala 25 Ile Lys Gly Thr Val Val Gly Asn Phe Met Giu Trp Tyr Asp Phe Gly Ile Le u Ser Asp Ala Gly Phe 145 Phe Gly Thr Gly Val1 225 Gin Al a Leu Leu Ser 305 Le u Pro Al a Gly Gin Le u Val1 Ser 115 Trp Th r Pro T yr Val1 195 Arg Le u Giu Leu Gly 275 Ser Ser Leu Tyr Le u Tyr Glu Val1 Gly 100 Thr Ala Gi y Asp Leu 180 Thr Ile Arg Pro Gi y 260 Ile Tyr Al a Pro Al a 340 Ile 40 Thr Gin Pro Gin Le u ValI Gi u 150 Arg Phe His Phe Arg 230 Ala Ala Ile Pro Al a 310 ValI Al a As n Val1 Leu Leu Lys Ile Leu 135 T yr Arq Al a Phe Le u 215 Ile Val1 Giy Val1 Val1 295 Val1 Gly Val Thr Thr Leu Gly ValI Gly 120 Le u Al a Gi y Al a Tyr 200 Thr Pro Vali Val1 Ala 280 Tyr Thr Met Al a Gi y Met Al a Gly Le u 105 Leu T yr Gly Ph e Gly 185 Giy Ala Giu Giu Ile 265 Al a Leu Val1 Trp Ala 345 Thr Thr ValI Leu Tyr Leu Leu Ala Phe 170 Ala Ala Ile Thr Lys 250 Arg Thr Giu Pro Ser 330 Thr Ile Val1 Phe Le u Thr Thr Lys 140 Thr Ala Val1 Al a Leu 220 Ala Th r His Thr Gin 300 Leu Arg Ile Ala Phe Gly Gly Met Ala 125 Met T yr Phe Vai Met 205 Gly Phe Giu T rp Al a 285 Ile Val1 Val1 Leu Val1 Thr Phe Pro Al a 110 Ala Val Val1 Le u Al a 190 Giu Ile Glu Asp Arg 270 Gly Gly Val Giy Met 350 Leu Gin Al a Leu Met Se r Gin Ala Asp 175 Ile Asp Ile Asn Pro 255 Pro Tyr Le u Met Arg 335 ValI Ile Leu Ser 385 Gly Leu Al a Phe Val1 465 Asp Val1 355 Met Leu Ser Thr Tyr 435 Thr Thr As n Al a Al a Al a Asn 405 Phe Met Ser Ser Asp 485 Lys Gi y Thr Ser Lys 425 Ala Pro Gin Met Tyr Ser 395 Phe Gly Al a Le u Val1 475 Phe 365 Al a Phe Gly Asp Val1 445 Se r As n Asp Leui Ser Thr Ile 430 Ala Phe Gin Gin Ser Gly Thr 415 Val1 Le u Pro Asp Glu 495 <210> 501 <211> 1509 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(1486) <223> RXA02030 <400> 501 gcqcctaaca tctcattgta tqggattgac tctaataatc ggtaattatt ggaatctatt attgtgtgag gcgataactc cac His cta Len atc Ile gct Ala acg Thr att Ile aca. Thr gtt Val1 ttg Leu aaq Lys atc Ile ttc Phe t ct Ser aaa Lys tac Tyr 45 Ctg Leu cca Pro 15 cgq Arg ttt Phe ttc Phe tcctqtqqaa acatcgcaaq gtg acc aca act gat Val Thr Thr Thr Asp 1 ggg cag acg qca acc Giy Gin Thr Ala Thr gca gca gcc tcc acc Ala Ala Ala Ser Thr gcg tac gct gcg gca Ala Tyr Ala Ala Ala qcc aat gac aac cca Ala Asn Asp Asn Pro 115 163 211 259 307 acc Thr gtg aac ctg ttg Val. Asri Leu Leu tcg ttt gcc acc Ser Phe Ala Thr ggt ott gcg ttc Gly Leu Ala Phe gct cgt cca ctc Ala Arg Pro Leu gt Gly tca atc att ttc Ser Ile Ile Phe gg Gly 95 cac ttc ggt gao His Phe Gly Asp cgt gtg Arg Val 100 gga cgc aaa Gly Arg Lys acc atc ttg Thr Ile Leu 120 acc ttg atc ggt Thr Leu Ile Gly ctg ctg acc atg Leu Leu Thr Met ggc att gcc Gly Ile Ala 115 gga atc: att Gly Ile Ile atc ggc ctg ctg Ile Gly Leu Leu cct Pro 125 act tat ggt cay Thr Tyr Gly Gin gt c ValI 130 gca ccg Ala Pro 135 gcg ctg ttg gcg Ala Leu Leu Ala atg cgt ttc tgc Met Arg Phe Cys ggc ctg ggo ott Gly Leu Gly Leu ggc Gly 150 ggt gaa tgg tct Gly Glu Trp Ser got gcg ttg ctg Ala Ala Leu Leu got Ala 160 ggt gaa aac gcg Gly Giu Asn Ala aac: act cac cgo Asn Thr His Arg gct Al a 170 cgt got gca atg Arg Ala Ala Met cca cag otg *ggt Pro Gin Leu Gly gca cog Ala Pro 180 ttt ggt ttC Phe Gly Phe Ott goo cat Leu Ala His ttg goc aat qgt Leu Ala Asn Gly atg ctc att ctg Met Leu Ile Leu qtc ggt gtg Val Gly Val 195 acc tgg ggt Thr Trp Gly cay gao ggc gat Gin Asp Gly Asp ott Leu 205 cac gyc gcg tto His Gly Ala Phe atg Met 210 tgg cgt Trp Arg 215 ctg oca tto otg Leu Pro Phe Leu tot Ser 220 tog gog ato atg Ser Ala Ile Met at o Ile 225 goa gtt ggo oty Ala Val Gly Leu gtg cyt tto toa Val Ary Phe Ser gag gaa act oca Giu Glu Thr Pro tto: aag cay got Phe Lys Gin Ala gtt Val1 245 787 835 883 gat cag ggc aag Asp Gin Gly Lys gtg aag tot cog Val Lys Ser Pro ot c Leu 255 aag gag otg tto Lys Giu Leu Phe aag act Lys Thr 260 too cot gyc Ser Pro Gly aco ttg ttc Thr Leu Phe 280 ct Pro 265 gtt gtg cay got Val Val Gin Ala ttg ato atg Leu Ile Met tao oty gtt aco Tyr Leu Val Thr tyg att oty tog Trp Ile Leu Ser oty too act tat Leu Ser Thr Tyr 275 tat gyc ato ggt Tyr Gly Ile Gly 290 ttt gag ttc ttg Phe Giu Phe Leu 931 979 aat ogo: Asn Ary 295 ago aco gga aao Ser Thr Gly Asn otg tot att cog Leu Ser Ile Pro 1027 cag ttg cag ctg gcc acc atc gtg ttc ttc gcc atc atg atc cct gtg 1075 Gin Leu Gin Leu Ala Thr Ile Val Phe Phe Ala Ile Met Ile Pro Val 310 315 320 325 tca gqc tgq ttq qct gat qtq tqq qgt cgt aaa aac acc ctg acc ttg 1123 Ser Gly Trp Leu Ala Asp Val Trp Giy Arg Lys Asn Thr Leu Thr Leu 330 335 340 gct tct gtg ctg ctt atc ggc ttt ggt ctg acg ttt aat ctg ctt ctc 1171 Ala Ser Val Leu Leu Leu Gly Phe Gly Leu Thr Phe Asn Leu Leu Leu 345 350 355 gat cca gag acc gcc acc aag acc acc gtg ttc atc ttc ttg ttc gtg 1219 Asp Pro Giu Thr Ala Thr Lys Thr Thr Val Phe Ile Phe Leu Phe Vai 360 365 370 ggc atg agc atc atg ggt ctg atc ttt gga ccc atg tcg gca att ttg 1267 Giy Met Ser Ile Met Gly Leu Ile Phe Gly Pro Met Ser Ala Ile Leu 375 380 385 ccg gag ctc ttc ccc acc aac gtc cgc tao acg ggc tcc gga ato gcc 1315 Pro Glu Leu Phe Pro Thr Asn Val Arg Tyr Thr Gly Ser Gly Ile Ala 390 395 400 405 tac aat gtc too tcg atc otc ggt gca qot att gca ccg tto ato gca 1363 Tyr Asn Val Ser Ser Ile Leu Gly Ala Ala Ile Ala Pro Phe Ile Ala 410 415 420 acg tgg ctg gtg tcc gag ttt toa gtg gcg tac qtc qgc tat tao ctc 1411 Thr Trp Leu Val Ser Glu Phe Ser Val Ala Tyr Val Gly Tyr Tyr Leu 425 430 435 atc ato gtc acc gca att acc ttt gtt gcg gtg otg acg atg aag gaa 1459 Ile Ile Val Thr Ala Ile Thr Phe Val Ala Val Leu Thr Met Lys Glu 440 445 450 aac aaa aac cac gac ctc cga gag gtc taaaagattt ttgcttatcg 1506 Asn Lys Asn His Asp Leu Arg Giu Val 455 460 a og 1509 <210> 502 <211> 462 <212> PRT <213> Corynebacteriun glutamioum <400> 502 Val Thr Thr Thr Asp His Ser Thr Giu Leu Asn Pro Ser Asp Pro Gly 1 5 10 Gly Gin Thr Ala Thr Leu Val Ile Asp Lys Lys Thr Lys Arg Arg Val 25 Ala Ala Ala Ser Thr Ile Giy Thr Thr Ile Giu Phe Tyr Asp Phe Tyr 40 Ala Tyr Ala Ala Ala Ala Val Val Val Phe Pro Ser Leu Phe Phe Pro 55 Ala Asn Asp Asn Pro Thr Val Asn Leu Leu Ala Ser phe Ala Thr Phe 70 75 Gly Phe Thr Gin Gin 145 Gly Gin Ile Phe Ile 225 Phe Glu Met Ser Tyr 305 Ile Asn Phe Ile Leu Ala Phe Gly Met Vai 130 Gly Glu Leu Leu Met 210 Ala Lys Leu Leu Tyr 290 Phe Met Thr Asn Phe 370 Asp Gly 115 Gly Leu Asn Gly Va1 195 Thr Val Gin Phe Ser 275 Gly Glu Ile Leu Leu 355 Leu Arg 100 Ile Ile Gly Ala Ala 180 Gly Trp Gly Ala Lys 260 Thr Ile Phe Pro Thr 340 Leu Phe Val Val Ala Ile Leu Glu 165 Pro Va1 Gly Leu Va1 245 Thr Tyr Gly Leu Va1 325 Leu Leu Va1 Ala Gly Thr Ala Gly 150 Asn Phe Leu Trp Trp 230 Asp Ser Thr Asn Gin 310 Ser Ala Asp Gly Arg Arg Ile Pro 135 Gly Thr Gly Ala Arg 215 Va1 Gin Pro Leu Arg 295 Leu Gly Ser Pro Met 375 Pro Lys Leu 120 Ala Glu His Phe His 200 Leu Arg Gly Gly Phe 280 Ser Gin Trp Val Glu 360 Ser Leu Ala 105 Ile Leu Trp Arg Phe 185 Gln Pro Phe Lys Pro 265 Tyr Thr Leu Leu Leu 345 Thr Ile Gly 90 Thr Gly Leu Ser Ala 170 Leu Asp Phe Ser Lys 250 Va1 Leu Gly Ala Ala 330 Leu Ala Met Ser Leu Leu Ala Gly 155 Arq Ala Gly Leu Leu 235 Val Va1 Va1 Asn Thr 315 Asp Leu Thr Gly Ile Ile Leu Leu 140 Ala Ala Asn Asp Ser 220 Glu Lys Gin Thr Gly 300 Ile Va1 Gly Lys Leu 380 Ile Phe Gly Ser 110 Pro Thr 125 Met Arg Ala Leu Ala Met Gly Phe 190 Leu His 205 Ser Ala Glu Thr Ser Pro Ala Thr 270 Thr Trp 285 Leu Ser Val Phe Trp Gly Phe Gly 350 Thr Thr 365 Ile Phe Gly His Leu Leu Tyr Gly Phe Cys Leu Ala 160 Trp Pro 175 Met Leu Gly Ala Ile Met Pro Val 240 Leu Lys 255 Leu Ile Ile Leu Ile Pro Phe Ala 320 Arg Lys 335 Leu Thr Val Phe Gly Pro Met Ser Ala Ile Leu Pro Giu Leu Phe Pro Thr 385 390 395 Gly Ser Gly Ile Ala Tyr Asn Val Ser Ser Ile 405 410 Ala Pro Phe Ile Ala Thr Trp Leu Val Ser Glu 420 425 Val Gly Tyr Tyr Leu Ile Ile Val Thr Ala Ile 435 440 Leu Thr Met Lys Giu Asn Lys Asn His Asp Leu 450 455 <210> 503 <211> 870 '212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(847) <223> RXA00186 <400> 503 agaagcccag cattttgttt agctcacctc taaaqctcct As n Leu The Thr Arg 460 Val1 Gly Ser Phe 445 Glu Arg Tyr Thr 400 Ala Ala Ile 415 Val Ala Tyr 430 Val Ala Val Val1 gatctqgata cgaggactcc tgcggaaaac cgtgtggcta qtgaaqctac ccgqcatctc atq ggg gag aag act Met Gly Glu tct Ser ata Ile ttc Phe acc Thr gat Asp tgc Cys gcg Al a aat As n ggt Gly cgc Arg cgc Arg gt g Val1 gt t Val cac His gga Gly att Ile gca Ala acg Thr ca c His ccc Pro tgg Trp gc C Ala ccg Pro 75 ga a Glu gtt ctg atc Val Leu Ile 15 gac Asp ttg Leu 45 gct Al a cat His gt C Val ggg Gi y gg g Gi y tca Se r cct Pro ct C Leu cyg Pro aag Lys ct t Leu ct t Le u gcc Al a ct c Leu 80 ggt Gly I Gly cct Pro gaa Glu ctg Leu qct Al a gaa Glu gtg Val gtc Val1 tca Se r tgt Cys gca Ala Ctc Leu cca Pro ttt Phe gtg Val1 atc Ile t tg Leu gcc Ala Lys gtg Val1 atc Ile gat Asp agt Ser gat Asp agt Se r 100 Thr cgg Arg tac Tyr tcC Se r gtg Val1 ga t Asp gct Al a 115 163 211 259 307 355 403 aac cag cat ota gtg gca gtc Asn Gin His Leu Val Ala Val 105 ggc ggg Gly Gly 110 gac aqc gcc Asp Ser Ala ggt ggc aat att Gly Gly Asn Ile 115 gcg gcg gtc atc gct caa cag ctg cgc gat cag atc acc cac caa gtt 499 Ala Ala Val Ile Ala Gin Gin Leu Arg Asp Gin Ile Thr His Gin Vai 120 125 130 ctt qtg tat ccg gtg atg gac gta atc ttg ctg gtg att tgt tct atc 547 Leu Vai Tyr Pro Vai Met Asp Vai Ile Leu Leu Val Ile Cys Ser Ile 135 140 145 att acc act ggt ttt qcg ctg ctc atq cat cca aaq agc aag qac aaq 595 Ile Thr Thr Giy Phe Aia Leu Leu Met His Pro Lys Ser Lys Asp Lys 150 155 160 165 acg gag acg att tct gat gaa ttc ctc gca gag atc caa gcg gga agt 643 Thr Giu Thr Ile Ser Asp Giu Phe Leu Aia Glu Ile Gin Ala Giy Ser 170 175 180 gaa aag atc tcc att ctg cgt tcg acc cct qct gaa aaa gcc aat gcg 691 Giu Lys Ile Ser Ile Leu Arg Ser Thr Pro Ala Giu Lys Ala Asn Ala 185 190 195 agc cgt tgg atc atg tac ttc gtt qgc gga att ggc ctg ctc tac agc 739 Ser Arg Trp Ile Met Tyr Phe Val Gly Giy Ile Giy Leu Leu Tyr Ser 200 205 210 gtg ttc agc ctg tgg aca ggt ggc gta acc gga Ct~g acg ttg aac tcc 787 Vai Phe Ser Leu Trp Thr Giy Gly Val Thr Gly Leu Thr Leu Asn Ser 215 220 225 ttc aac ttc ctg ttc ctg tca ctc ggc atq gtg ctc acc gct aat tac 835 Phe Asn Phe Leu Phe Leu Ser Leu Gly Met Val Leu Thr Aia Asn Tyr 230 235 240 245 ggg cca gag tat taagcaaagc ttattcgcga agg 870 Gly Pro Glu Tyr <210> 504 <211> 249 <212> PRT (213> Corynebacterium glutamicum <400> 504 Met Gly Glu Lys Thr Ser Val Ala Tyr Val His Asp Val Leu Ile Lys 1 5 10 Gly Val Pro Val Arg Ile Tyr Asn Pro His Pro Asn Asp Gly Pro Leu 25 Pro Val Phe Ile Tyr Phe His Gly Gly Gly Trp Val Leu Gly Asp Leu 40 Giu Ser Val Asp Ser Thr Val Arq Asp Ile Ala Vai Ala Ser Giy Ala 55 Leu Cys Ile Ser Val Asp Tyr Arg Arg Ala Pro Glu His Pro Phe Leu 70 75 Ala Ala Leu Asp Asp Cys Gin Val Vai Thr Glu Ala Val Leu Asn Gly 90 Giu Leu Ala Gly Ile Thr 130 Val Ile 145 Lys Ser Ile Gin Glu Lys Gly Leu 210 Leu Thr 225 Leu Thr Aila Gly 115 His Cys Lys Ala Ala 195 Leu Leu Al a As n Al a Leu Ile 150 Thr Giu Ser Val1 The 230 Gi y His Val1 120 Tyr Thr Thr Ile Trp 200 Ser Ph e Giu Val1 Ala Val1 Phe Se r 170 Ile Met Trp Phe Ala Gin Met Al a 155 Asp Leu Tyr Thr Le u 235 Gly Leu 125 Val1 Leu Phe Ser Val 205 Giy Leu <210> 505 <211> 468 <212> DNA <213> Corynebacterium glutamioum <220> <221> CDS <222> (101)..(451) <223> RXA00187 <400> 505 gottattogo gaaggoatoo aaggaaogtg gggattoatt. aggoatttto gqgttgattt ccttcaccgg tctgqgtgtt tto Phe tac Tyr atc Ile gac acc tog Thr Ser tot gga Ser Gly atc gaa Ilie Glu atg gqc att Ile ct g Le u g cc Ala ott. gca. Ala atc Ile atc Ile cag a cg Thr gt g Val1 30 ooa Pro tat ct Pro t ca Ser o ca Pro atg cttcaattco cgttctacgc gtg atc too gga ttt Vai Ile Ser Gly Phe 1 gto atc gog tto oto Val Ile Ala Phe Leu ggt ggc tog aaa tto Gly Gly Ser Lys Phe gtg gat ott ggc got Val Asp Leu Gly Ala agt gat go gog aoo 115 163 211 259 307 I Asp Met Gly Leu Val Leu Gin Ala Tyr Gin Met Ser Asp Gly Ala Thr 60 aac ctg ctc att ccg ttc ttc gcg ctg cca tat ttg gcc aat ttc aag 355 Asn Leu Leu Ile Pro Phe Phe Ala Leu Pro Tyr Leu Ala Asn Phe Lys 75 80 atc aaa ttc agc caa gtg qtg ggc tat aca gtt ccq cct gtc ctc gtt 403 Ile Lys Phe Ser Gin Val Val Gly Tyr Thr Val Pro Pro Val Leu Val 95 100 gtt atc gcc gtg atc tgc att tac ctg ttc ctg cga gca tca atc att 451 Val Ile Ala Val Ile Cys Ile Tyr Leu Phe Leu Arg Ala Ser Ile Ile 105 110 115 taaaaagatg cttctcg 468 <210> 506 <211> 117 (212> PRT <213> Corynebacterium giutamicum <400> 506 Val Ile Ser Gly Phe Phe Thr Ser Ile Ser Thr Ala Thr Thr Trp Pro 1 5 10 Val Ile Ala Phe Leu Tyr Ser Gly Leu Leu Asn Ile Ala Val Pro Ser 25 Gly Gly Ser Lys Phe Ile Ile Glu Ala Pro Tyr Ile Ile Pro Thr Pro 40 Val Asp Leu Gly Ala Asp Met Gly Leu Val Leu Gin Ala Tyr Gin Met 55 Ser Asp Gly Ala Thr Asn Leu Leu Ile Pro Phe Phe Ala Leu Pro Tyr 70 75 Leu Ala Asn Phe Lys Ile Lys Phe Ser Gin Val Vai Gly Tyr Thr Val 90 Pro Pro Val Leu Val Val Ile Ala Val Ile Cys Ile Tyr Leu Phe Leu 100 105 110 Arg Ala Ser Ile Ile 115 <210> 507 <211> 1329 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(1306) <223> RXA01667 <400> 507 tctcggcgtt gatgatcatc cgcaatatca tgccgccgca agattccgct Lttccagact ttqctcattc cttcctctat tactqctcqc catcatcggc atq att ttq Met Ile Leu 1 qgg cct Gly Pro tac act TIyr Thr aag gtg ttq ggt Lys Val Leu Gly att ggt tgg tcg Ile Gly Trp Ser ga t Asp cat ctt tcc act His Leu Ser Thr acg gtg ctc Thr Val Leu ttt gac cgt Phe Asp Arg att Ile gcg att gtg ttt Ala Ile Val Phe tcg atg ccg tat Ser Met Pro Tyr tcg atg aag Ser Met Lys gcg tat tcg Ala Tyr Ser ggc gtg cgt act Gly Val Arg Thr ggc Gly 45 atq aag acg atg Met Lys Thr Met t gg Trp act gcg Thr Ala atq ttt gtg ggg Met Phe Val Gly tgg ggt ctg ttc Trp Gly Leu Phe ttg ctg ggt ctg Leu Leu Gly Leu ttq ttc caa ccg Leu Phe Gin Pro tgg ggt acc gat Trp Gly Thr Asp tgg ttc ggc atq Trp Phe Giy Met at g Met ttg ccg gtt ggt Leu Pro Val Gly gtt ggt qgt ttt Val Gly Gly Phe ggt Gi y act gct gct gcg Thr Ala Ala Ala gtg ggt Val Gly 100 act gcg ttq Thr Ala Leu acc tct gcg Thr Ser Ala 120 gag Glu 105 tct tcg ggt gcg Ser Ser Gly Ala gct qcg atg tct Ala Ala Met Ser ttq ggc ttt Leu Gly Phe 115 qga att att Gly Ile Ile acg gtg ggt act Thr Val Gly Thr gct qcg att gtt Ala Ala Ile Val ggt Gly 130 ttc aca Phe Thr 135 acq tgq ggt att Thr Trp Gly Ile aaq Lys 140 aag qgc aag act Lys Gly Lys Thr g cg Ala 145 qcg atg cct gq Aia Met Pro Ala ca 9 Gin 150 ttg ccg tgg gat Leu Pro Trp Asp cgt tcg ggt tat Arg Ser Gly Tyr gat aag ctg agt Asp Lys Leu Ser 547 595 643 cgt ccg tcg att Arg Pro Ser Ile aaq gcg agt acg Lys Ala Ser Thr ccg tct gcg att Pro Ser Ala Ile gag cct Glu Pro 180 ttg gcg ctg Leu Ala Leu tcc att aat Ser Ile Asn 200 act ggc att att Thr Gly Ile Ile ttg Leu 190 ttg act gtt gcg Leu Thr Val Ala gtt gcg tat Val Ala Tyr 195 cag att ccg Gin Ile Pro cag tgg ttg ggt Gin Trp Leu Gly atg ttc cca acc Met Phe Pro Thr ttq ttt Leu Phe 215 qcg atq tca ttt Ala Met Ser Phe gtq Val1 220 gtc ggc att qtq Val Gly Ile Val gc Gly 225 atq gga att atg Met Gly Ile Met cgt Arg 230 ttg ttg aag aag Leu Leu Lys Lys gag tat ttg gat Giu Tyr Leu Asp cgc Arg 240 gac acc gtg aat Asp Thr Val Asn 835 883 gtg tcg ggc gcg Val Ser Gly Ala acg gat tac ctc Thr Asp Tyr Leu gcg ttt ggt att Ala Phe Gly Ile gcc tcg Ala Ser 260 att gct cct I~1 lie Ala Pro Phe Val Leu 280 gct Al a 265 gcg att gct gat Ala Ile Ala Asp tgg gtt cct ctt Trp Val Pro Leu gtg gtg ctg Val. Val Leu 275 tgg gtt gcq Trp Val Ala ggc acc atc aac Gly Thr Ile Asn tgt ttc ttc ttt Cys Phe Phe Phe ttc Phe 290 cct cgt Pro Arg 295 ttc ttt ggc gag Phe Phe Gly Giu aag Lys 300 tgg ctg gag cgc Trp Leu Glu Arg gcg Ala 305 atc ttc ggt tgg Ile Phe Gly Trp 9gt Gly 310 tggqgct act gcc Trp Ala Thr Ala gtt gct acc ggt Val Ala Thr Gly gcg ttg ctg aag Ala Leu Leu Lys atc Ile 325 1027 1075 1123 gtg gat ccg aag Val Asp Pro Lys aag tcg gga gcg Lys Ser Gly Ala ctt Leu 335 aat gag tac ggc Asn Glu Tyr Gly gtg qct Val Ala 340 tat atc qgt Tyr Ile Gly atc gcg gtg Ile Ala Val 360 gct cca ttt gaa Ala Pro Phe Glu atc Ile 350 ggc atq acc atc Gly Met Thr Ile atc gcg ccg Ile Ala Pro 355 gcg tcg ttg Ala Ser Leu 1171 1219 ctc gca ggc ttt LeU Ala Gly Phe acc Thr 365 atg ggg ttg ggt Met Gly Leu Gly t gg Trp 37 0 att qtt Ilie Val 375 gcg atc gtg att Ala Ile Val Ile ggc ctc gcg tgg Gly Leu Ala Trp ctg aaq tgg ttq Leu Lys Trp Leu 1267 gag cgc gga cat Glu Arg Gly His cgc ggc gag ggt Arg Gly Giu Giy aag ccg caa Lys Pro Gin 400 taaaggttgg 1316 aagcgccggg tct 1329 <210> 508 <211> 402 <212> PRT <213> Corynebacterium giutamicum <400> 508 Met Ilie Leu Gly Pro Lys Val Leu Gly Leu 1 5 10 Ile Gly Trp Ser Asp His Leu Ser Thr Tyr Thr Thr Val Leu Ile 25 Pro Tyr Ser Met Lys Phe Asp Arg Giy 40 Ala Ile Val Phe Ala Ser Met Met Lys Thr Val Arg Thr GI y Met Ile Trp Al a Met Val1 Ala 145 ASP Ser ValI Thr Gly 225 Asp Phe Pro Phe Al a 305 Al a Glu Thr Trp Le u Phe Al a Ser Gly 130 Ala Lys Al a Al a Val1 210 Met Thr Gly Leu Phe 290 Ile Leu Tyr Ile Ala Leu Gly Al a Leu 115 Gly Met Leu Ile Val 195 Gin Gly Val1 Ile Vai 275 Trp Phe Leu Gly Ile 355 Tyr Gly Met Val1 100 Gly Ile Pro Se r Glu 180 Al a Ile Ile As n Ala 260 Val1 Val1 Gly Lys Val1 340 Ala Ser Le u Met Gly Ph e Ile Ala Asp 165 Pro Tyr Pro Met Ser 245 Ser Leu Ala T rp Ile 325 Ala Pro Thr Phe 70 Leu Thr Th r Phe Gin 150 Arg Le u Ser Leu Arg 230 Val1 Ile Phe Pro Gly 310 Val T yr Ile Met Phe Val1 Leu Ala 120 Thr Pro Ser Leu Asn 200 Ala Leu Gly Pro Leu 280 Phe Ala Pro Gly Val1 360 Ph e Gin Gly Giu 105 Thr Trp Trp Ile His 185 Gin Met Lys Al a Al a 265 Gly Phe Thr Lys Phe 345 Le u Val1 Pro Phe 90 Ser Val1 Gly Asp Gly 170 Thr Trp Ser Lys Al a 250 Ala Thr Gly Ala Leu 330 Ala Ala Gly Val1 75 Val Ser Gly Ile Leu 155 Lys Gly Leu Phe Pro 235 Thr Ile Ile Glu Al a 315 Lys Pro Giy Gin Trp Gly Gly Thr Lys 140 Arg Ala Ile Gly Val1 220 Glu Asp Al a As n Lys 300 Val1 Ser Ph e Phe Trp Gly Gly Ala Ph e 125 Lys Ser Ser Ile Ser 205 Val1 Tyr Tyr Asp Cys 285 Trp Ala Gly Glu Thr 365 Gly Thr Phe Giu 110 Al a Gly Gly Thr Le u 190 Met Gly Leu Leu Tyr 270 Cys Le u Thr Al a Ile 350 Met Leu Asp Gly Ala Ala Lys Tyr Asn 175 Leu Phe Ile Asp Ile 255 Trp Phe Glu Gly Leu 335 Gly Gly Phe Glu Thr Al a Ile Thr Ile 160 Pro Thr Pro Val1 Arg 240 Al a Val1 Phe Arg Ile 320 As n Met Leu Gly Trp Ala Ser Leu Ile Val Ala Ile Val Ile Phe Gly Leu Ala Trp 370 375 380 Gly Leu Lys Trp Leu Pro Glu Arg Gly His Val Arg Gly Glu Gly Lys 385 390 395 400 Pro Gin <210> '<211> c212> <213> <220> <221> <222> <223> 509 1776 DNA Corynebacteriun C DS (1753) RXA02171 glutamicum <400> 509 aaccacattc gtcattactt acatctatgt catgtttgcg aacaaqaact tggagcctcg tcaggctgct. attcgccaga agatggaagg ttaatcagat atg aat tcc act att Met Asn Ser Thr Ile ctc ctt gca caa Leu Leu Ala Gin ga c Asp gct gtt tct gag Ala Val Ser Glu ggc Gly gtc ggt aat ccg Val Gly Asn Pro aac atc agt Asn Ile Ser ctt cgc gtg Leu Arg Val gtC Val1 ttC gtC gtc ttC Phe Val Val Phe att Ile 30 att gtg acg atg Ile Val Thr Met acc gtg gtg Thr Val Val tac acc ggt Tyr Thr Gly ggc aag agc acc Giy Lys Ser Thr gaa tcc acc gac Glu Ser Thr Asp ggt gct Giy Ala tcc ttc tcc qga Ser Phe Ser Gly acc Thr 60 cag aac ggt ctg Gin Asn Gly Leu gct Ala atc gca ggt gac Ile Ala Gly Asp tac Tyr ctg tct gca gcg Leu Ser Ala Ala ttc ctc qga atc Phe Leu Gly Ile gjt t Val1 80 qgt gca att tca Gly Ala Ile Ser ct C Leu aac gqt tac qac Asn Gly Tyr Asp ttc ctt tac tcc Phe Leu Tyr Ser ggc ttC ttc gtc Gly Phe Phe Val gca tgg Ala Trp 100 ctt gtt gca Leu Val Ala ttc acc atg Phe Thr Met 120 ctg Leu 105 ctg ctc gtg gca Leu Leu Val Ala gag Giu 110 cca ctt cgt aac Pro Leu Arg Asn gtg ggc cgc Val Gly Arg 115 aaa cca gtc Lys Pro Val 451 499 gct gac gtg ctg Ala Asp Val Leu tcc Ser 125 ttc cqa ctg cgt Phe Arg Leu Arg cgc gtc gct qcq gcc tgc ggt acc ctc gcq gtt acc ctc ttt tac ttg Arg Val Ala Ala Ala Cys Gly Thr Leu Ala Val Thr Leu ?he Tyr Leu 140 145 ato Ile 150 gct cag atg gct Ala Gin Met Ala gca ggt tcg ott Ala Gly Ser Leu gtg Val1 160 tcc gtt ctg ctg Ser Val Leu Leu gao Asp 165 atc cac gag ttc Ilie His Giu Phe aag Lys 170 tgg cag goa. gtt Trp Gin Ala Val gt t Val1 175 gtc ggt ato gtt Val Gly Ile Val ggc att Gly Ile 180 gto atg atc Val Met Ile gtt cag atg Val Gin Met 200 tao gtt ott ott Tyr Vai Leu Leu ggt atg aag ggc Giy Met Lys Gly aco aca tao Thr Thr Tyr 195 gco att atg Ala Ile Met att aag goa gtt Ile Lys Ala Val otg gto ggt ggo Leu Val Gly Giy gtt Va i 210 aco gtt Thr Vai 215 otg aco tto gto Leu Thr Phe Vai gtg tot ggt ggo Val Ser Gly Giy aoo aoo Ott tta Thr Thr Leu Leu aa t As n 230 gao got gtt gag Asp Ala Val Giu aag Lys 235 oao gcc got toa His Ala Ala Ser ga t Asp 240 tao got gco ac Tyr Ala Ala Thr aag Lys 245 gqg tao gat ooa Gly Tyr Asp Pro aoo Thr 250 oag ato otg gag Gin Ile Leu Giu ct Pro 255 ggt ctg oag tao Gly Leu Gin Tyr ggt gca Gly Ala 260 act ctg ac Thr Leu Thr ott gga aco Leu Gly Thr 280 oag otg gao tto Gin Leu Asp Phe too ttg got oto Ser Leu Ala Leu got otg tgt Ala Leu Cys 275 tao acc gtt. Tyr Thr Val got ggt otg coa Ala Gly Leu Pro cao His 285 gtt otg atg ogo Val Leu Met Arg tto Phe 290 oot aoo Pro Thr 295 gco aag gaa goa Ala Lys Giu Ala aag tot gtg aoo Lys Ser Val Thr tgg Trp 305 got ato gto oto Ala Ile Val Leu 931 979 1027 1075 1123 att Ile 310 ggt gog tto tao Gly Ala Phe Tyr atg aoo otg gto Met Thr Leu Val ggt tao ggo got Gly Tyr Gly Ala goa otg gto ggt Ala Leu Val Gly oca Pro 330 gao ogo gto att Asp Arg Val Ile gco Ala 335 goa ooa ggt got Ala Pro Gly Ala got aat Ala Asn 340 got got got Ala Ala Ala gog otg att Ala Leu Ilie 360 cot Pro 345 otg otg goo tto Leu Leu Ala Phe ott ggt ggt too Leu Gly Gly Ser ato tto atg Ile Phe Met 355 gtg gto goa Val Val Ala 1171 1219 too goa gtt gog Ser Ala Val Ala tto Phe 365 got aoo gtt oto Ala Thr Val Leu ggt Ott Gly Leu 375 goa att aoo goa Ala Ile Thr Ala too Ser 380 got got. gtt ggt Ala Ala Val Gly gao ato tao aao Asp Ile Tyr Asn 1267 gct Al a 390 gtt atc cgc aac Val Ile Arg Asn ggt Gly 395 cag tcc acc gaa Gin Ser Thr Giu gag cag gtc cga Glu Gin Val Arg 1315 tcc cgc atc acc Ser Arg Ile Thr gtt Val 410 gtc gtc att ggc Val Val Ile Giy ctg Leu 415 att tcc att gtc Ile Ser Ile Val ctg qga Leu Giy 420 1363 att ctt gca Ile Leu Ala gca gtt gca Ala Vai Aia 440 acc cag aac gtt Thr Gin Asn Val ttc ctc gtg gcC Phe Leu Val Ala Ctg gcC ttc Len Ala Phe 435 tcc ctg tac Ser Leu Tyr 1411 1459 gca tcc gct aac Aia Ser Ala Asn cca acc atc ctg Pro Thr Ile Leu tac Tyr 450 tgg aag Trp Lys 455 aag ttc aac acc Lys Phe Asn Thr acc Th r 460 ggc gCt gtg gcc Gly Ala Val Ala atc tac acc ggt Ile Tyr Thr Gly Ctc Len 4 atc tcc gcg ctg Ile Ser Ala Leu ctg atc ttc ctg Le Ile Phe Leu cca gca gtc tcc Pro Ala Val Ser 1507 1555 1603 aat gac agc gca Asn Asp Ser Ala atg Met 490 gtt cca ggt gca Val Pro Gly Ala ga c Asp 495 tgg gca atc ttc Trp Ala Ile Phe oca ctg Pro Len 500 aag aac cca Lys Asn Pro atc ggc act Ile Gly Thr 520 9gc Gly 505 ctc gtc tcc atc Leu Val Ser Ile cca Pro 510 ctq gca ttc atc Len Ala Phe Ile gct ggt tgg Ala Gly Trp 515 ctt gct gee Len Ala Ala 1651 1699 ttg gtt ggc aag Leu Val Gly Lys cca Pro 525 gac aac atg gat Asp Asn Met Asp gaa atg Glu Met 535 gat cac Asp His 550 gaa gtt cgt tcc Gin Val Arg Ser acc ggt gtc ggt Thr Giy Val Gly gtt Val 545 gaa aag gct gtt Gin Lys Ala Val 1747 taaatctagt ttctgaagtt att 1776 <210> 510 <211> 551 <212> PRT <213> Corynebacterium giutamicum <400> 510 Met Asn Ser Thr Ile Len Len Ala Gin 1 5 Giy Asn Pro Ile Leu Asn Ile Ser Val 25 Thr Met Thr Val Val Leu Arg Val Gly 40 Asp 10 Ala Val Ser Gin Gly Val Phe Val Val Phe Ile Ile Val Gin Ser Thr Lys Ser Thr Se r Asp Phe Tyr Thr Giy Gly Ala Ser Phe Ser Gly Thr Gin Asn Gly Leu Ala Gly Phe Arq Arq Thr 145 Ser Gly Lys Giy Le u 225 Tyr Leu Al a Arg Trp 305 Gly Pro Gly Ile Al a Phe As n Gln 130 Le u Val1 I le Gly Val 210 Thr Al a Gin Leu Phe 290 Al a Tyr Gl y Ser Ala Ile Val1 Val1 115 Lys Phe Leu Val1 Thr 195 Ala Thr Al a Tyr Aia 275 T yr Ile Giy Ala Ile Gly Ser Ala 100 Gly Pro T yr Leu Gly 180 Thr Ile Leu Thr Gly 260 Le u Thr Val1 Ala Ala 340 Phe Asp Leu Trp Arg Val1 Leu Asp 165 Ile Tyr Met Leu Lys 245 Ala Gys Val Le u Al a 325 As n Met 55 Leu Gly Val1 Thr Val1 135 Ala His Met Gin Val1 215 Asp Tyr Leu Gly Thr 295 Gly Leu Aia Leu Se r T yr Ala Met 120 Ala Gin Giu Ile Met 200 Leu Al a Asp Thr Thr 280 Al a Al a Val1 Al a Ile Al a Asp Leu 105. Ala Ala Met Phe Ala 185 Ile Thr Val1 Pro Thr 265 Al a Lys Phe Gly Pro 345 Se r Ala Gly 90 Leu Asp Ala Ala Lys 170 T yr Lys Phe Glu Thr 250 Gin Gly Glu Tyr Pro 330 Leu Ala Ser 75 Phe Le u Val1 Cys Gi y 155 Trp Val1 Ala Val1 Lys 235 Gin Le u Le u Ala Le u 315 Asp Le u Val1 Phe Le u Val1 Le u Gly 140 Al a Gin Le u Val1 Lys 220 His Ile Asp Pro Arg 300 Met Arg Al a Al a Leu Tyr Ala Ser 125 Thr Gly Ala Leu Leu 205 Val Ala Leu Phe His 285 Lys Thr Val1 Ph e Phe Gly Ser Glu 110 Phe Le u Ser Val1 Gly 190 Le u Ser Al a Glu Ile 270 Val1 Se r Le u Ile Glu 350 Ala Ile Ile Pro Arq Al a Le u Val1 175 Gly Val1 Gly Se r Pro 255 Ser Leu Val1 Val1 Al a 335 Leu Thr Val1 Gly Leu Le u Val1 Val 160 Val1 Met Gly Gly Asp 240 Gly Leu Met Thr Leu 320 Ala Gi y ValI 355 360 365 Leu Ala Val Val Ala Gly Leu Ala Ile Thr Ala Ser Ala Ala Val Gly 370 375 380 His Asp Ile Tyr Asn Ala Val Ile Arg Asn Gly Gin Ser Thr Giu Ala 385 390 395 400 Giu Gin Val Arg Val Ser Arg Ile Thr Vai Val Val Ile Gly Leu Ile 405 410 415 Ser Ile Vai Leu Giy Ile Leu Ala Met Thr Gin Asn Val Ala Phe Leu 420 425 430 Val Ala Leu Ala Phe Ala Vai Ala Ala Ser Ala Asn Leu Pro Thr Ile 435 440 445 Leu Tyr Ser Leu Tyr Trp Lys Lys Phe Asn Thr Thr Gly Ala Val Ala 450 455 460 Ala Ile Tyr Thr Gly Leu Ile Ser Ala Leu Leu Leu Ile Phe Leu Ser 465 470 475 480 Pro Ala Val Ser Gly Asn Asp Ser Ala Met Vai Pro Gly Ala Asp Trp 485 490 495 Ala Ile Phe Pro Leu Lys Asn Pro Gly Leu Val Ser Ile Pro Leu Ala 500 505 510 Phe Ile Ala Gly Trp Ile Gly Thr Leu Val Gly Lys Pro Asp Asn Met 515 520 525 Asp Asp Leu Ala Ala Giu Met Giu Val Arg Ser Leu Thr Gly Val Gly 530 535 540 Val Giu Lys Ala Val Asp His 545 550 <210> 511 <211> 1333 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(1333) <223> RXA00902 <400> 511 ttgttattgq tttgttcact cccatgcaat gtacqatcgg ttctaacgtc tacggcaatt gacacgtcaa tttaattcag gaaaggggtg gggagaattt atg tot agt ggt ttt 115 Met Ser Ser Gly Phe 1 gaa tat gtt caa cat cct cga cga gcc ctc cct ccg cct ata cct gaa 163 Giu Tyr Val Gin His Pro Arg Arg Ala Leu Pro Pro Pro Ile Pro Giu 15 cgg aaa ggt cct gcc gca gca ttc ctq ccg gga act ttc cat ccc att 211 Arg Lys Gly Pro Ala Ala Ala Phe Leu Pro Gly Thr Phe His Pro Ile 30 aat cca aag Asn Pro Lys aat att gca gcg Asn Ile Ala Ala cac gat cag gtg His Asp Gin Val cta tct gyt Leu Ser Gly tgg ggc Trp Gly aaa ttt gtg Lys Phe Vai cqt tgg Arg Trp 60 ctc ttg gta ttg ttg tcc att ttg gte Leu Leu Vai Leu Leu Ser Ile Leu Vai ate Ile atc att ggc atc Ile Ile Gly Ile aac As n 75 ctc atc ttg gac Leu Ile Leu Asp ggt Giy 80 gtc tac gga ttt Val Tyr Giy Phe gg t Gi y act ttt tea acc Thr Phe Ser Thr cag atg tac caa Gin Met Tyr Gin gt t Val1 gcg aaa gat cca Ala Lys Asp Pro etc att Leu Ile 100 ggt gtg etg Giy Val Leu ace ace aca Thr Thr Thr 120 ggt ate ttg got Giy Ile Leu Ala gee ttg gtg eaa Ala Leu Val Gin tea tea ace Ser Ser Thr 115 att gtg tog Ile Val Ser aeg ttg acg gtg Thr Leu Thr Val qca gtt qgt aeg Ala Val Gly Thr gtg cot Val Pro 135 gtg gog att cog Val Ala Ile Pro att ott ggc gea Ile Leu Gly Ala aat As n 145 atc ggt aeg aeg Ile Gly Thr Thr ato Ile 150 ace gog atg oto Thr Ala Met Leu gtt Val1 155 gog ttt tot tat Ala Phe Ser Tyr gtg Val1 160 ggt gaa ego agg Gly Giu Arg Arg gag Giu 165 547 595 643 ttt aag oga got Phe Lys Arg Ala ttt Phe 170 aeg qtt gec gee Thr Val Ala Ala cat gtg tgg ttt His Val Trp Phe aao gtg Asn Val 180 oto gte att Leu Val Ile ego aca att Arg Thr Ile 200 gtt eta ttt gtt Val Leu Phe Val gtg Val1 190 gaa ttg etc ttt Giu Leu Leu Phe oat oca ttc: His Pro Phe 195 aca act ggt Thr Thr Gly 691 739 agt ggt gcg ate Ser Giy Ala Ile acg gag ate aca Thr Glu Ile Thr ggc tot Gly Ser 215 ttg Oct ace agt Leu Pro Thr Ser ggt Gly 220 gtg atg ace aag Val Met Thr Lys ttt gat 000 eca Phe Asp Pro Pro aco Thr 230 oaa ott etg ggt Gin Leu Leu Giy aat ggt ott ate Asn Gly Leu Ile ggt Gi y 240 tog ate ggc aat Ser Ile Gly Asn ct Pro 245 agt att, tog gog Ser Ile Ser Ala gta tgt ott gtg Val Cys Leu Val gtg Val1 255 ggo aco att ott Gly Thr Ile Leu att otg Ile Leu 260 att tog gtg Ile Ser Val cgt Arg 265 gee atg agt tct Ala Met Ser Ser ato oga ace att Ile Arg Thr Ile aeg gea gog Thr Ala Ala 275 ace gta ace tea att atg gao aag gtg ato aat oca gag aao ago co 97 979 Thr Val Thr Ser Ile Met Asp Val Ile Asn Pro Glu Asn Ser Pro 290 9cg Al a 295 a cg Tb r Val1 ttg be u Ala cac His 375 ca g Gin act Thr 280 acg Th r ctc Le u qct Al a gg t Gly att Ile 360 ct C Leu ct t Leu 9C Al a ctt Leu gt c Vali tct Ser 330 aac As n aqc Ser gtq Val1 aat As n agt Ser 410 aat Asn 300 C Ala gtC Val1 Gly cag Gin ttC Phe 380 att Ile agc Se r gtg Vali caa Gin 335 gtg Val1 t tc Phe gca Ala ttg Leu ttc Phe acc Thr 320 aaq Lys acc Thr gct Ala tta Leu gCC Aia 400 ctt Leu gct Ala ttg Leu atg Met cag Gin 370 gtg Val1 aaa Lys ttg Leu cag Gin 325 gt C Val1 act Thr t tg Leu att Ile aac As n 405 1027 1075 1123 1171 1219 1267 1315 1333 <210> 512 <211> 411 <212> PRT <213> Corynebacterium qiutamicum <400> 512 Met Ser Ser Gly Phe Glu Tyr Val Gin 1 5 Pro Pro Ile Pro Glu Arg Lys Giy Pro Thr Phe His Pro Ile Asn Pro Lys Asn 40 Vai Leu Leu Ser Gly Trp Gly Lys Phe 55 Leu Ser Ile Leu Vai Ile Ile Ile Gly 70 Val Tyr Gly Phe Gly Thr Phe Ser Thr Lys Asp Pro Leu Ile Gly Val Leu Ile His 10 Ala Ile Val Ile Tb r 90 Gly Pro Al a Al a Arg As n Gin Ile Arq Al a Al a Trp Leu Met Le u Arg Phe Ser Leu Ile Tyr Ala Leu Pro Asp Val Asp Val1 Ala 100 Val Gin Ser Ser Thr Thr Thr Thr Thr Asn 145 Gly Val Leu Thr Ile 225 Ser Thr Thr Pro Ile 305 Val Pro Ala Ile Leu 385 Glu Gly 130 Ile Glu Trp Phe Leu 210 Phe Ile Ile Ile Glu 290 Leu Ala Leu Met Gin 370 Val Lys 115 Ile Gly Arg Phe His 195 Thr Asp Gly Leu Thr 275 Asn Gly Ser Leu Phe 355 Ala Leu Thr Val Thr Arg Asn 180 Pro Thr Pro Asn Ile 260 Ala Ser Val Met Gly 340 Ala Ala Cys Ala Ser Thr Glu 165 Val Phe Gly Pro Pro 245 Leu Ala Pro Leu Gin 325 Val Thr Leu Ile Asn 405 Val Ile 150 Phe Leu Arg Gly Thr 230 Ser Ile Thr Lys Phe 310 Pro Ile Phe Ile Pro 390 Leu Pro 135 Thr Lys Val Thr Ser 215 Gin Ile Ser Val Ala 295 Thr Val Leu Ala His 375 Gin Thr 120 Val Ala Arg Ile Ile 200 Leu Leu Ser Val Thr 280 Thr Leu Ala Gly Ile 360 Leu Leu Ala 105 Thr Ala Met Ala Leu 185 Ser Pro Leu Ala Arg 265 Ser Ile Met Ala Ala 345 Val Ile Ala Arg lle Leu Phe 170 Val Gly Thr Gly Ile 250 Ala Ile Leu Val Ser 330 Asn Ser Val Asn Ser 410 Pro Val 155 Thr Leu Ala Ser Met 235 Val Met Met Ser Thr 315 Gly Val Asp Asn Val 395 Tyr Ile 140 Ala Val Phe Ile Gly 220 Asn Cys Ser Asp Asn 300 Ala Val Gly Gin Phe 380 Ile 125 Ile Phe Ala Val Ala 205 Val Gly Leu Ser Lys 285 Phe Ser Val Thr Gly 365 Thr Ile Leu Ser Ala Val 190 Thr Met Leu Val Gin 270 Val Trp Ser Lys Thr 350 Glu Gly His Gly Tyr Met 175 Glu Glu Thr Ile Val 255 Ile Ile Ser Val Gin 335 Val Phe Ala Leu Leu Thr Val Thr Ala Val 160 His Leu Ile Lys Gly 240 Gly Arg Asn Phe Thr 320 Lys Thr Ala Leu Ala 400 110 Ala Val Gly <210> 513 <211> 212> <213> <220> <221> <222> <223> 1440 DNA Corynebacterium glutarnicum CDS (1417) RXA0094 1 <400> 513 agccggggtg gccgtttgcg tgtacgggtt tt.gcttatcg acgcccactt ctgattttaa aggcaaatat tttgtgtcac agcqagtaat cttttcgggc atg aac cta acc Met Asn Leu Thr aat gac agg ctc Asn Asp Arg Leu cga ctg ccc gta Arg Leu Pro Val tcc aaa cat aaa Ser Lys His Lys aag att Lys Ile ctt ggc ggc Leu Gly Gly ctg atc tct Leu Ile Ser tca Ser ggt atc ggc tgg Gly Ile Gly Trp gca Al a 30 ttg gat gcc atg Leu Asp Ala Met gat gtc gga Asp Val Gly ggc cta tcc Gly Leu Ser ttc gtc atg gct Phe Val Met Ala ttg gcc act cat Leu Ala Thr His cct act Pro Thr qaa, act tcc ctg Giu Thr Ser Leu ct c Le u gqa tcc atc qgt Gly Ser Ile Gly gtt qgc atq gcc Val Giy Met Ala ggc gct tcg ctg Gly Ala Ser Leu ggC Gly ggt ttg ctg gcg Gly Leu Leu Ala ga c Asp 80 aag ttg gqg cgt Lys Leu Gly Arg cga Arg 307 355 403 caa qtt tit gcg Gin Val Phe Ala tct ttg cta tt Ser Leu Leu Val tat Tyr ggc gtt gcc act Gly Val Ala Thr qgc gcg Gly Ala 100 tcg gcg ctt Ser Ala Leu gtt gga ctt Val Gly Leu 120 gtg tcg ctcj gca Val Ser Leu Ala ttg atg gcg ctg Leu Met Ala Leu cgc ttc gtc Arg Phe Val 115 act ctg att. Thr Leu Ile 451 499 ggc ctg ggc gct Gly Leu Gly Ala ga a Giu 125 ctc ccc gtt gca Leu Pro Val Ala tcc Ser 130 tcc gag Ser Giu 135 ttt tct cca cga Phe Ser Pro Arg gtt cgt ggc cgc Vai Arg Gly Arg atg Met 145 gtc gtt atc ctg Val Val Ile Leu gag Giu 150 gcg itt tgg gcg Ala Phe Trp Ala ggc tgg atc atg Gly Trp Ile Met gca atc gtc gga Ala Ile Val Gly ttt gtc gtg gca Phe Val Val Ala gga Gly 170 tcc gat aat ggt Ser Asp Asn Gly tgg Trp 175 cgt tgg gcg tta Arg Trp Ala Leu gct ctt Ala Leu 180 gqc tgt qtc cct gca att tac gcg gtg tat gtc cqt ctc gga ctt cca Gly Cys Val gaa toa gta Gin Ser Val 200 Pro 185 Ala Ile Tyr Ala Val1 190 Tyr Val Arg Len Gly Leu Pro 195 gaa gca gaa Gin Ala Glu ogt tto ctg gag Arg Phe Leu Giu aaa ggc cgg cac Lys Gly Arg His gac Asp 210 goc atc Ala Ile 215 gtt gtt tco ttc Val Val Ser Phe gaa Gin 220 gaa got goo got Gin Ala Ala Ala gaa ggt aaa got Glu Gly Lys Ala gat qcc aoc acc Asp Ala Thr Thr gtg qtt cat gac Val Val His Asp aac Asn 240 got goc gag ggt Ala Ala Gin Gly too Ser 245 gta too ato tgg Val Ser Ile Trp got got ttg cgo Ala Ala Len Arg cgo acc gto gcg Arg Thr Val Ala otg tgg Leu Trp 260 atc gtg tgg Ile Val Trp att oca tog Ile Pro Ser 280 tto Phe 265 tgo ato aao ttg Cys Ile Asri Leu too Ser 270 tao tao gga goo Tyr Tyr Gly Ala tto att tgg Phe Ile Trp 275 aag tot tto Lys Ser Phe ctg otg gtt gc Leu Leu Val Ala gao Asp 285 ggt tto aoo oto Gly Phe Thr Leu gtg Val 290 oaa tto Gin Phe 295 aot otg ato ato Thr Leu Ile Ile ttg got oag ott Leu Ala Gin Leu ggo tat gog gtt Gly Tyr Ala Val gcg tgg ttg att Ala Trp Leu Ile gaa Giu 315 aag tgg ggo cgt Lys Trp Gly Arg cgo Arg 320 ago aca ttg gcc Ser Thr Len Ala a og Thr 325 1027 1075 1123 tto otg gtt ggt Phe Leu Val Gly got ato tot gca Ala Ile Ser Ala gog Ala 335 oto tao ggo ttg Len Tyr Gly Leu goa aat Ala Asn 340 gtg gag tgg Val Gin Trp otg ggo goa Len Gly Ala 360 ato otg gto goa Ile Len Val Ala tgt tta ota too Cys Leu Len Ser tto tto aao Phe Phe Asn 355 ott tat oooc Len Tyr Pro 1171 1219 tgg ggo goa otg Trp Gly Ala Len tat Tyr 365 goo att ggg oog Ala Ile Gly Pro act aat Thr Asn 375 gto ogt gga aot Val Arg Gly Thr g ga Gly 380 aog ggt got goo Thr Gly Ala Ala gog Ala 385 gga tto ggg ogo Gly Phe Gly Arg att Ile 390 got too ato ato Ala Ser Ile Ile oog oto att gtt Pro Leu Ile Val oog Pro 400 ooa gtg att got Pro Val Ile Ala ttt Phe 405 1267 1315 1363 ggt gga ooa att Gly Gly Pro Ile got Al a 410 ttg tto got oto Leu Phe Ala Leu ttt Phe 415 goo aoo gog ttt Ala Thr Ala Phe cag aag qgt aag Gin Lys Gly Lys gog ato Ala Ile 420 tot oto Ser Len gca gog att gog gcg ttt aog otg cot gag Ala Ala Ile Ala Ala Phe Thr Len Pro Glu 1411 430 gct gat tagtgagatc cttccaccag ttt 1440 Ala Asp <210> 514 <211> 439 <212> PRT <213> Corynebacterium giutamicum <400> 514 Met Asn Leu Thr Arg Asn Asp Arg Leu Asp Arg Leu Pro Val Thr Ser 1 5 10 Lys His Lys Lys Ile Leu Gly Gly Ser Gly Ile Gly Trp Ala Leu Asp 25 Ala Met Asp Val Gly Leu Ile Ser Phe Val Met Ala Ala Leu Ala Thr 40 His Trp Gly Leu Ser Pro Thr Giu Tlhr Ser Leu Leu Gly Ser Ile Gly 55 Phe Val Gly Met Ala Ile Gly Ala Ser Leu Gly Gly Leu Leu Ala Asp 70 75 Lys Leu Gly Arg Arq Gin Val Phe Ala Leu Ser Leu Leu Val Tyr Gly 90 Val Ala Thr Gly Ala Ser Ala Leiu Ser Val Ser Leu Ala Met Leu Met 100 105 110 Ala Leu Arg Phe Val Val Gly Leu Gly Leu Gly Ala Giu Leu Pro Val 115 120 125 Ala Ser Thr Leu Ile Ser Glu Phe Ser Pro Arg Lys Val Arg Gly Arg 130 135 140 Met Val Val Ilie Leu Glu Ala Phe Trp Ala Leu Gly Trp Ile Met Ala 145 150 155 160 Ala Ile Val Gly Thr Phe Val Val Ala Gly Ser Asp Asn Gly Trp Arg 165 170 .175 Trp Ala Leu Ala Leu Gly Cys Val Pro Ala Ile Tyr Ala Val Tyr Val 180 185 190 Arg Leu Gly Leu Pro Glu Ser Val Arg Phe Leu Glu Lys Lys Gly Arg 195 200 205 His Asp Glu Ala Giu Ala Ile Val Val Ser Phe Glu Glu Ala Ala Ala 210 215 220 Ala Glu Gly Lys Ala Ala Asp Ala Thr Thr Ala Val Val His Asp Asn 225 230 235 240 Ala Ala Glu Gly Ser Val Ser Ile Trp Ser Ala Ala Leu Arg Lys Arg 245 250 255 Thr Val Ala Leu Trp Ile Vai Trp Phe Cys Ile Asn Leu Ser Tyr Tyr 260 265 270 Gly Leu Pro 305 Ser T yr Leu Pro Al a 385 Pro Thr Lys The 275 Lys Tyr Leu Leu Phe 355 Leu Phe Ile Phe Lys 435 Ile Ser Al a Al a Ala 340 Phe Tyr Gly Al a Ala 420 Trp Phe Val1 Thr 325 As n As n Pro Arg Phe 405 Ile Ile Gin Al a 310 Phe Val1 Leu Thr Ile 390 Gly Ala Pro Phe 295 Ala Leu Glu Gly Asn 375 Ala Gly Ala Le u Leu Leu Gly Gin 345 Trp Arg Ile Ile Ala 425 Leu Ile Ile Ser 330 Ile Gly Gly Ile Ala 410 Ala Ala Thr 300 Lys Ile Val1 Leu Gi y 380 Pro Phe Thr Asp 285 Leu Trp Ser Ala Tyr 365 Thr Leu Al a Leu GI y Al a Gly Ala Gly 350 Al a Gi y Ile Leu Pro 430 Thr Le u Arg 320 Le u Le u Gly Al a Pro 400 Al a Gin Ser Leu Ala Asp <210> 515 <211> 1704 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1681) <223> RXN00449 <400> 515 tcgttggctt acatgqtcat tgatgaccgg qctgaatatg tqagaaaatc catcccttct ttaagcaagg gagtgaatta cagaaaagga ttgttcaqca atg agc aca cct gac Met Ser Thr Pro Asp 1 att aaa qaa ggc tcg gca gaa tca cog qqc gaa gta atg gtc qtt gga Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu Val Met Val Val Gly 15 gac agg cga gag tqg cgt cqa caa qca acc gqo atc att gcc ggc oto Asp Arg Arg Glu Trp Arg Arg Gin Ala Thr Gly Ile Ile Ala Gly Leu 30 gtC tta gcc Val Leu Ala gcc ctg gtc tat ctt ctc ttc ccc tcg Ala Leu Val Tyr Leu Leu Phe Pro Ser tcc gtg gaa Ser Val Glu acc gtc Thr Val atg caa tcc agt Met Gin Ser Ser gtc gat cca gaa Val Asp Pro Giu act Thr gaa tac acc aac Glu Tyr Thr Asn 259 307 355 403 aac As n gcg atg cgt ctt Ala Met Arg Leu act Th r gct gca gtc aca Ala Ala Val Thr ttg atg gca gtg Leu Met Ala Val tgg atg aca gaa Trp Met Thr Glu gca atc cca cta gca gca Ala Ile Pro Leu Ala Ala 95 acc gca ctt atc Thr Ala Leu Ile ccg ttq Pro Leu 100 gtt gca ttc Val Ala Phe ccg tat gcc Pro Tyr Ala 120 gct ttc cag gtt Ala Phe Gin Val gtg Val1 110 gac ttt ggq aag Asp Phe Gly Lys gca aca gct Ala Thr Ala 115 ttt ctt atg Phe Leu Met 451 499 aac cct acg agc Asn Pro Thr Ser ctc ttc ttg ggc Leu Phe Leu Gly qca ctt Ala Leu 135 ggc ctg cag aaa Gly Leu Gin Lys t gg Trp 140 aac cta cac cga Asn Leu His Arg cgt Arg 145 atg gct cta gcg Met Ala Leu Ala gt c Val1 150 gtg cta gct gtt Val Leu Ala Val act aag cca aag Thr Lys Pro Lys ttg gtc ttg ggt Leu Val Leu Gly atg gtg gca act Met Val Ala Thr gga. Gi y 170 ttt ttg tcc atq Phe Leu Ser Met gtg tct aac act Val Ser Asn Thr gca acg Ala Thr 180 gcc gtg gtt Ala Val Val gag act gtg Glu Thr Val 200 tta ccg atc ggt Leu Pro Ile Gly atg Met 190 tcg gta ctg gca. Ser Val Leu Ala ctg aco gct Leu Thr Ala 195 act gga ctc Thr Gly Leu 547 595 643 691 739 787 835 883 ggc gga atg aaa Gly Gly Met Lys caa aag aaa ttc Gin Lys Lys Phe atg ctg Met Leu 215 tcc att gct tat Ser Ile Ala Tyr t ct Ser 220 gct tcc atc ggt Ala Ser Ile Gly t ca Ser 225 ctc gqc acc tta Leu Gly Thr Leu att ile 230 qgc acg cca ccc Gly Thr Pro Pro gcc ttg ctt gct Ala Leo Leu Ala tat atg tct gaa Tyr Met Ser Glu cat gat atc cac His Asp Ile His atc Ile 250 gga ttt ggt cag Gly Phe Gly Gin atg att ctt qgt Met Ile Leu Gly gta cca Val Pro 260 att qct gtc Ile Ala Val ttc acc atc atc Phe Thr Ile Ile gcg Al a 270 tgg ctt gtg ttg Trp Leu Val Leu acc acc gtg Thr Thr Val 275 ttc aag oca Phe Lys P-ro 280 gaa atg aaa gaa Giu Met Lys Gin atc Ile 285 cct ggc gga cgt Pro Gly Gly Arg gaa Gin 290 ctg ate aaa Leu Ile Lys cgt gaa Arg Glu 295 atc gct gaa atg Ile Ala Giu Met ggg Gly 300 ccg tgg act gca Pro Trp Thr Ala cag gtc aca gtg Gin Val Thr Val ggt Gly 310 act Th r gtt att ttt gcg Val Ile Phe Ala cta gat tgg ace Len Asp Trp Thr 330 get gea ctg get Ala Ala Leu Ala gte ttc att eca Val Phe Ile Pro tta Len 325 1027 1075 1123 ggt tcc cag etc Gly Ser Gin Len tet Se r 335 atc aat gac tec Ile Asn Asp Ser etc att Leu Ile 340 ggc ate get Gly Ile Ala ace gge gaa Thr Gly Glu 360 gee Al a 345 gge etg etq atg Gly Leu Leu Met ate gtt ccc get Ile Val Pro Ala aae ttt aaa Asn Phe Lys 355 ctt eca tgg Leu Pro Trp egc att ctt gat Arg Ile Len Asp egt act gca gge Arg Thr Ala Gly gaa Glu 370 gat gtt Asp Val 375 etc ttg ett ttt Len Leu Len Phe ggt Giy 380 ggc ggg ctt tea Gly Gly Leu Ser ctt Leu 385 tet geg atg ttt Ser Ala Met Phe 1171 1219 1267 1315 1363 age aeg gga ctt Ser Thr Gly Leu tee Se r 395 eta tgg ate ggt Leu Trp Ile Giy eta get aag gga Leu Ala Lys Giy gat gee ett eca Asp Ala Leu Pro tte att etc ate Phe Ile Leu Ile gee att get gte Ala Ile Ala Val ctg gtg Leu Val 420 ttg tte etg Leu Phe Leu etg eca ate Len Pro Ile 440 ace Thr 425 gag tte ace tee Gin Phe Thr Ser ace gea aca geg Thr Ala Thr Ala gea ace tte Ala Thr Phe 435 ace gca ggt Thr Ala Gly 1411 1459 atg ggt gge gte Met Gly Giy Val gee Ala 445 gta ggt ate gga Val Giy Ile Gly gge gag Gly Gin 455 eag aat gtt etg Gin Asn Val Leu etg ace ate eca Leu Thr Ile Pro gea etg tee gea Ala Leu Ser Ala ace Thr 470 tgt geg tte atg Cys Ala Phe Met eca gtg gea aeg Pro Val Ala Thr eca aae geg att Pro Asn Ala Ile gea Ala 485 1507 1555 1603 tte ggc tee gge Phe Gly Ser Gly tae Tyr 490 att aag ate gge Ile Lys Ile Gly ga a Gin 495 atg gte aag ggt Met Val Lys Gly ggt etg Gly Len 500 tgg etg aae Trp Leu Asn ate Ile 505 ate gea gte ate Ile Ala Val Ile att aeg att tte Ile Thr Ile Phe ace tae tte Thr Tyr Phe 515 1651 gta geg ate eca etc ttt gge ate atg ctt taaaagttaa eaggeccgca 1701 Val Ala Ile Pro Leu Phe Gly Ile Met Leu 520 525 gtc 1704 <210> 516 <211> 527 <212> PRT <213> Corynebacterium glutamicum <400> 516 Met Ser Thr Pro Asp Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu 1 5 10 Val Met Val Val Gly Asp Arg Arg Glu Trp Arg Arg Gin Ala Thr Gly 25 Ile Ile Ala Gly Leu Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro 40 Ser Asn Ser Val Glu Thr Val Met Gin Ser Ser Gly Val Asp Pro Glu 55 Thr Glu Tyr Thr Asn Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile 70 75 Leu Met Ala Val Trp Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr 90 Ala Leu Ile Pro Leu Val Ala Phe Pro Ala Phe Gin Val Val Asp Phe 100 105 110 Gly Lys Ala Thr Ala Pro Tyr Ala Asn Pro Thr Ser Phe Leu Phe Leu 115 120 125 Gly Gly Phe Leu Met Ala Leu Gly Leu Gin Lys Trp Asn Leu His Arg 130 135 140 Arg Met Ala Leu Ala Val Val Leu Ala Val Gly Thr Lys Pro Lys Gin 145 150 155 160 Leu Val Leu Gly Phe Met Val Ala Thr Gly Phe Leu Ser Met Trp Val 165 170 175 Ser Asn Thr Ala Thr Ala Val Val Met Leu Pro Ile Gly Met Ser Val 180 185 190 Leu Ala Leu Thr Ala Glu Thr Val Gly Gly Met Lys Asn Gin Lys Lys 195 200 205 Phe Ala Thr Gly Leu Met Leu Ser Ile Ala Tyr Ser Ala Ser Ile Gly 210 215 220 Ser Leu Gly Thr Leu Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala 225 230 235 240 Tyr Met Ser Glu Ser His Asp Ile His Ile Gly Phe Gly Gin Trp Met 245 250 255 Ile Leu Gly Val Pro Ile Ala Val Val Phe Thr Ile Ile Ala Trp Leu 260 265 270 Val Leu Thr Thr Val Phe Lys Pro Giu Met Lys Giu Ile Pro Gly Gly 275 280 285 Arg Giu Leu Ile Lys Arq Gu Ile Ala Giu Met Gly Pro Trp Thr Ala 290 295 300 Pro Gin Val Thr Val Gly Vai Ile Phe Ala Ala Ala Ala Leu Ala Trp, 305 310 315 320 Val Phe Ile Pro Leu Thr Leu Asp Trp Thr Gly Ser Gin Leu Ser Ile 325 330 335 Asn Asp Ser Leu Ile Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val 340 345 350 Pro Ala Asn Phe Lys Thr Gly Giu Arg Ile Leu Asp Trp Arg Thr Ala 355 360 365 Gly Giu Leu Pro Trp Asp Val Leu Leu Leu Phe Giy Gly Gly Leu Ser 370 375 380 Leu Ser Ala Met Phe Thr Ser Thr Gly Leu Ser Leu Trp Ile Gly Giu 385 390 395 400 Leu Ala Lys Giy Leu Asp Ala Leu Pro Ile Phe Ile Leu Ile Phe Ala 405 410 415 Ile Ala Val Leu Val Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Ala 420 425 430 Thr Ala Ala Thr Phe Leu Pro Ile Met Gly Gly Val Ala Val Gly Ile 435 440 445 Gly Leu Thr Ala Gly Gly Giu Gin Asn Val Leu Leu Leu Thr Ile Pro 450 455 460 Val Ala Leu Ser Ala Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro 465 470 475 480 Pro Asn Ala Ile Ala Phe Gly Ser Gly Tyr Ile Lys Ile Gly Glu Met 485 490 495 Val Lys Gly Gly Leu Trp Leu Asn Ile Ile Ala Val Ile Leu Ile Thr 500 505 510 Ile Phe Thr Tyr Phe Val Ala Ile Pro Leu Phe Gly Ile Met Leu 515 520 525 <210> 517 <211> 1028 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1)..(1005) <223> FRXA00449 <400> 517 ctg gca ctg acc got gag act gtg ggc Leu Ala Leu Thr Ala Glu Thr Val Gly gga GI y atg aaa aac caa Met Lys Asn Gin aag aaa Lys Lys ttc gcc act Phe Ala Thr tca ctc ggo Ser Leu Gly ctc atg ctg too Leu Met Leu Ser gct tat tct gct Ala Tyr Ser Ala tcc atc ggt Ser Ile Gly ctt got geg Leu Ala Ala acc tta att ggc Thr Leu Ile Gly acg Th r cca ccc aat gcc Pro Pro Asn Ala tat atg Tyr Met tot gaa tog oat Ser Glu Ser His ate cac atc gga Ile His Ile Gly ggt cag tgg atg Gly Gin Trp Met att Ile ctt ggt gta cca Leu Gly Val Pro gct gte gte ttc Ala Val Val Phe atc ate gcg tgg Ile Ile Ala Trp ctt Leu gtg ttg ace acc Val Leu Thr Thr gtg Val1 ttc aag cca gaa Phe Lys Pro Glu atg Met 90 aaa gaa ate Oct Lys Glu Ile Pro qgc gga Gly Gly cqt gaa ctg Arg Giu Leu oct cag gte Pro Gin Val 115 aaa ogt qaa ate Lys Arg Giu Ile gaa atg ggq ccq Glu Met Gly Pro tgq act gca Trp Thr Ala 110 etg get tgg Leu Ala Trp aca gtg ggt gtt Thr Val Gly Vai ttt gcg gca get Phe Ala Ala Ala gca Al a 125 gte tto Val Phe 130 att eca tta act Ile Pro Leu Thr eta Leu 135 gat tgg ace ggt Asp Trp Thr Gly eag ete tot ate Gin Leu Ser Ile aat Asn 145 gao toe etc att Asp Ser Leu Ile ate got gee ggc Ile Ala Ala Gly etg atg ttt ate Leu Met Phe Ile eec get aae ttt Pro Ala Asn Phe aaa Lys 165 ace gge gaa ege Thr Gly Giu Arg ctt gat tgg cgt Lou Asp Trp Arg act gca Thr Ala 175 ggc gaa ott Gly Giu Leu ott tet geg Leu Ser Ala 195 eca Pro 180 tgg gat gtt etc Trp Asp Val Lou ttg Lou 185 ott ttt ggt ggc Leu Phe Giy Gly ggg ott tea Gly Leu Ser 190 ate ggt gaa Ile Gly Glu atg ttt ace age Met Phe Thr Ser aeg Thr 200 gga ett tee eta Gly Leu Ser Leu eta got Leu Ala 210 aag gga ott gat Lys Gly Leu Asp ott oca ate ttc Leu Pro Ile Phe att Ile 220 etc ate tto gee Leu Ile Phe Ala att Ile 225 get gte ctg gtg Ala Val Leu Val ttg Leu 230 ttc etg ace gag Phe Leu Thr Giu ttc Phe 235 ace tee aac ace Thr Ser Asn Thr aca gcg gca acc ttc ctg cca atc atg ggt ggc gtc gcc gta ggt atc 768 Thr Ala Ala Thr Phe Leu Pro Ile Met Gly Gly Val Ala V/al Gly Ile 245 250 255 gga ctg acc gca ggt ggc gag cag aat gtt ctg ctg ctg acc atc cca 816 Gly Leu Thr Ala Gly Gly Glu Gin Asn V/al Leu Leu Leu Thr Ile Pro 260 265 270 gtc gca ctg tcc gca acc tgt gcg ttc atg ctt cca gtg gca acg cct 864 Val Ala Leu Ser Ala Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro 275 280 295 cca aac gcg att gca ttc ggc tcc ggc tac att aag atc ggc gaa atg 912 Pro Asn Ala Ile Ala Phe Gly Ser Gly Tyr Ile Lys Ile Gly Giu Met 290 295 300 gtc aag qgt ggt ctg tgg ctg aac atc atc qca qtc atc ctc att acg 960 V/al Lys Gly Gly Leu Trp Leu Asn Ile Ile Ala V/al Ile Leu Ile Thr 305 310 315 320 att ttc acc tac ttc gta qcg atc cca ctc ttt ggc atc atq ctt 1005 Ile Phe Thr Tyr Phe Val Ala Ile Pro Leu Phe Gly Ile Met Leu 325 330 335 taaaagttaa cagqcccgca qtc 1028 <210> 518 (211> 335 <212> PRT <213> Corynebacterium giutamicum <400> 518 Leu Ala Leu Thr Ala Giu Thr V/al Gly Gly Met Lys Asn Gin Lys Lys 1 5 10 Phe Ala Thr Gly Leu Met Leu Ser Ile Ala Tyr Ser Ala Ser Ile Gly 25 Ser Len Gly Thr Leu Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala 40 Tyr Met Ser Giu Ser His Asp Ile His Ile Gly Phe Gly Gin Trp Met 55 Ilie Leu Gly V/al Pro Ile Ala Val V/al Phe Thr Ile Ile Ala Trp Leu 70 75 S/al Len Thr Thr Val Phe Lys Pro Giu Met Lys Glu Ile Pro Gly Gly 90 Arg Glu Len Ilie Lys Arg Gin Ilie Ala Gin Met Gly Pro Trp Thr Ala 100 105 110 Pro Gin Val Thr V/al Gly Val Ile Phe Ala Ala Ala Ala Len Ala Trp 115 120 125 V/al Phe Ile Pro Leu Thr Len Asp Trp Thr Gly Ser Gin Len Ser Ile 130 135 140 Asn Asp Ser Leu Ile Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val 145 Pro Gly Leu Leu Ile 225 Thr Gly Val1 Pro Val1 305 Ile Ala Glu Ser Ala 210 Al a Ala Leu Al a Asn 290 Lys Phe Phe Pro 180 Met Gly Leu Thr Ala 260 Ser Ile Gly Tyr Lys 165 Trp Phe Leu Val Phe 245 Gly Ala Ala Leu Phe 325 Glu Leu Thr 200 Leu Leu Ile Gin Ala 280 Ser Asn Ile Arg Leu 185 Gly Pro' Thr Met Asn 265 Phe Gly Ile Pro Ile 170 Leu Leu Ile Glu Gly 250 Val Met T yr Ile Leu 330 155 Leu Phe Ser Phe Ph e 235 Gly Le u Leu Ile Al a 315 Phe Trp Gly Trp 205 Leu Se r Al a Leu Val1 285 Ile Ile Ile Arg Gly 190 Ile Ile As n Val1 Thr 270 Al a Gly Leu Met Thr 175 Leu Gly Phe Thr Gly 255 Ile Thr Giu Ile Leu 335 <210> 519 (211> 448 <212> DNA '<213> Corynebacterium glutamicun <220> <221> CDS <222> (101)..(448) <223> FRXA01755 <400> 519 tcgttggctt acatggtcat tgatgaccgg gctgaatatg tgagaaaatc catcccttct ttaagcaagg gagtgaatta cagaaaagga ttgttcagca atg agc aca cct gac Met Ser Thr Pro Asp 1 att aaa gaa gqc tcg gca gaa tca ccg ggc gaa gta atg qtc gtt gga Ile Lys Glu Gly Ser Ala Giu Ser Pro Gly Giu Val Met Val Val Gly 15 gac agg cga gag tgg cgt cga caa gca acc ggc atc att gcc ggc ctc Asp Arg Arg Glu Trp Arg Arg Gin Ala Thr Gly Ile Ile Ala Gly Leu 30 115 163 211 gtc tta gcc gcc ctg gtc tat ctt ctc ttc ccc tcg aac tcc gtg gaa 259 Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro Ser Asn Ser Val Glu 45 acc gtc atg caa tcc agt ggc gtc gat cca gaa act gaa tac acc aac 307 Thr Val Met Gin Ser Ser Gly Val Asp Pro Glu Thr Glu Tyr Thr Asn 60 aac gcg atg cgt ctt act gct gca gtc aca atc ttg atg gca gtg tgg 355 Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile Leu Met Ala Val Trp 75 80 tgg atg aca gaa gca atc cca cta gca gca acc gca ctt atc ccg ttg 403 Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr Ala Leu Ile Pro Leu 95 100 gtt gca ttc cct gct ttc cag gtt gtg gac ttt ggg aag gca gca 448 Val Ala Phe Pro Ala Phe Gin Val Val Asp Phe Gly Lys Ala Ala 105 110 115 <210> 520 <211> 116 <212> PRT <213> Corynebacterium glutamicum <400> 520 Met Ser Thr Pro Asp Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu 1 5 10 Val Met Val Val Gly Asp Arg Arg Glu Trp Arg Arg Gin Ala Thr Gly 25 Ile Ile Ala Gly Leu Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro 40 Ser Asn Ser Val Glu Thr Val Met Gin Ser Ser Gly Val Asp Pro Glu 55 Thr Glu Tyr Thr Asn Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile 70 75 Leu Met Ala Val Trp Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr 90 Ala Leu lie Pro Leu Val Ala Phe Pro Ala Phe Gin Val Val Asp Phe 100 105 110 Gly Lys Ala Ala 115 <210> 521 <211> 912 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(889) <223> RXA00269 <400> 521 tgcgatcttq gtgqttqtcq ccatqctqct gccgaggtgg accgaagcct aagcaaccag tagcagtgga ggcttaagac cgtgcqaagt tctccaaggc atg tta tcc atc aac 11 Met Leu Ser Ile Asn gga att tct aag Gly Ile Ser Lys ttc ttc ccc ggc Phe Phe Pro Gly gtg aat gag cgc Val Asn Glu Arg cgc gcg Arg Ala ttg cag cag Leu Gin Gin atc ggt tct Ile Gly Ser ct C Le u aaa ctc gat atg Lys Leu Asp Met gag ggc gat ttt Giu Gly Asp Phe qtc acc gtc Val Thr Val gct gtt tct Ala Val Ser aac ggt gog ggt aaa tcc acg ctq ctc Asn Gly Ala Gly Lys Ser Thr Leu Leu aac Asn ggc cgt Giy Arg ttg ctt gtt gat Leu Leu Val Asp ggc gag att tcc Gly Giu Ile Ser gac ggc aac aag Asp Gly Asn Lys 259 307 355 403 gta Val1 aac aag atg tca Asn Lys Met Ser cac aag cqt gcc His Lys Arg Ala cgc Arg tac atc ggc cgc Tyr Ile Gly Arg ttc cag gat cct Phe Gin Asp Pro gcc ggc acc gcg Ala Giy Thr Ala ccg Pro aat ctc acc att Asn Leu Thr Ile gaa gag Giu Giu 100 aat ctg gcc Asn Leu Ala gca ctg acc Aia Leu Thr 120 atc Ile 105 gcg ttg ctg cgc Ala Leu Leu Arg aaq cgc cgt gga Lys Arg Arg Gly ttq ggc ttt Leu Gly Phe 115 ctt gag cgc Leu Giu Arg tcq aag cgc cqt Ser Lys Arg Arg caa ttc aag cag Gin Phe Lys Gin ctt gag Leu Giu 135 ctg ggt ctg gaa Leu Gly Leu Giu aac As n 140 agg ctc act gcc Arg Leu Thr Ala aaa Lys 145 gtt ggt ttg ctc Val Gly Leu Leu ggc ggt cag cgt Gly Gly Gin Arg gca ttg tcc ctg Ala Leu Ser Leu ctg Le u 160 atg gct ggt ttt Met Ala Gly Phe 547 595 643 caa cct aaa atc Gin Pro Lys Ilie ctg ttg gat gag Leu Leu Asp Glu acc gca gcg ctt Thr Ala Ala Leu gat cca Asp Pro 180 cag cgt gca Gin Arg Ala gga aat ctg Gly Asn Leu 200 ctt gtg acc acc Leu Val Thr Thr ttg Leu 190 acc gaa aag atc Thr Glu Lys Ile gtg gca gat Vai Ala Asp 195 cag gca att Gin Ala Ile 691 739 act acq ctt atg Thr Thr Leu Met acq cac aac atg Thr His Asn Met cqc ctg ggc aat cgc ctg atc atg atg cat gaa ggc cag att gtc tac Arg Leu Gly Asn Arq Leu Ile Met Met His Giu Gly Gin Ile Vai Tyr 215 220 225 cag gca gat cag gct ace aaq tcg aag ttq act gtg cgc gat ttg ctg Gin Ala Asp Gin Ala Thr Lys Ser Lys Leu Thr Val Arg Asp Leu Leu 230 235 240 245 cag gag ttc gcc aac atc aag ggc gca aca ttg tct gac aag gcg ttc Gin Glu Phe Ala Asn Ile Lys Gly Ala Thr Leu Ser Asp Lys Ala Phe 250 255 260 etc ggc taaaaagagc ttgctttacg acg Leu Gly <210> 522 <211> 263 <212> PRT <213> Corynebacterium giutamicum <400> 522 Met Leu Ser Ilie Asn Gly Ile Ser Lys 1 Asn Asp Leu Ile Tyr Leu Arg Gin Lys 145 Met Al a Giu Phe Asn Asp Ile Thr Giy Glu 130 Val1 Al a Al a Arg Val1 Ala Gly Gly Ile Leu 115 Leu Gly Gly Leu Arg Thr Val1 As n Arg Glu 100 Gly Gi u Le u Phe Asp 180 5 Al a ValI Se r Lys Val1 Gi u Phe Arg Leu Thr 165 Pro Le u Ile Gly Val1 70 Phe Asn Al a Leu Ser 150 Gin Gin Gin Gly Arg 55 As n Gin Leu Leu Glu 135 Gly Pro Arg Gin Se r 40 Leu Lys Asp Al a Thr 120 Leu Gly Lys Ala Le u 25 Asn Le u Met Pro Ile 105 Ser Gly Gin Ile Giu 185 Thr 10 Lys Gly Val1 Se r Leu 90 Ala Lys Le u Arg Met 170 Leu Phe Le u Al a Asp Giu 75 Al a Leu Arg Giu Gin 155 Le u Val1 Phe Asp Gly Se r His Gly Leu Arg Asn 140 Ala Leu Thr Pro Met Lys Gly Lys Thr Arg Gi u 125 Arg Leu Asp Thr Gly Al a Ser Glu Arg Al a Gi y 110 Gin Le u Ser Giu Leu 190 Thr Giu Thr Ile Al a Pro Lys Phe Thr Leu His 175 Thr Val1 Gly Leu Ser Arg As n Arg Lys Al a Le u 160 Thr Giu Lys Ilie Val Ala Asp Gly Asn Leu Thr Thr Leu Met Val Thr His Asn 195 200 205 Met Glu Gin Ala Ile Arg Leu Gly Asn Arg Leu Ile Met Met His Giu 210 215 220 Gly Gin Ile Val Tyr Gin Ala Asp Gin Ala Thr Lys Ser Lys Leu Thr 225 230 235 240 Vai Arg Asp Leu Leu Gin Giu Phe Ala Asn Ile Lys Gly Ala Thr Leu 245 250 255 Ser Asp Lys Ala Phe Leu Gly 260 <210> 523 <211> 817 <212> DNA <213> Corynebacteriun giutamicum <220> <221> CDS <222> (817) <223> RXA00369 (400> 523 ggcgggaaat tacaatcagg catcggcgtt gtcgttgatg ggcgctcqcg ttqacggtgc gcagccagaa ggagttttag tttgcgatta tcgqtatcgt cgc Arg atc Ile t cg Ser gag Glu gtc Val1 qtg Val1 cqa Arq ctc Le u gat Asp aat Asn ggg Giy cca Pro ccg Pro t gg Trp agt Ser gcg Ala 120 tta Leu ttg Leu t cC Se r agt Ser cg Pro ccg Pro gt Gi y 105 ctg Leu gtg Val att Ile aaa Lys 9gC Gi y Arg a tg Met aag Lys ggg Gly agc Ser gag Giu acc Thr agt Ser 60 cgt Arg t cg Ser qgq di y ctt Leu Cgc Arg gaa Glu 30 atg Met ctc Leu atg Met gcc Ala tcg Ser 110 qgg Gly ga c Asp qaa Giu ttg Le u atc Ile Gly aag Lys ata Ile ttc Phe gga Gly ttt Phe ggc Gly gcC Al a atq Met 80 aat Asn ago Ser ggc Gi y Val1 1 acc Thr gtg Vai acc Thr ggc Gly gtg ValI gtg Val1 aaa Lys agt Se r ttc Phe gtg Val1 atc Ile gaa Giu ttt Phe gga Gi y ogo Arg cgc Ar g 130 ggg Gly ot c Le u qgg Al a gaa Glu ca g Gin tac T yr gt g Val1 115 aga Arg tca tog atc aaa Ser Ser Ile Lys otg Leu a tc Ile ggg Giy atg Met cag Gin ccg Pro 100 gag Glu ocg Pro caa Gln ggg Gly ttt Phe a cg Thr cat His ct g Leu cgc Arg gcc Al a 115 163 211 259 307 355 403 451 499 agc otg tot ggt ggt caa cgt cag Ser Leu Ser Gly Gly Gin Arg Gin .1 135 140 atc gcc gao ccc aco gtg ctg ctt< Ile Ala Asp Pro Thr Val Leu Leu 1 150 155 gao gaa cog ctg oga gao got tta Asp Giu Pro Leu Arg Asp Ala Leu 1 170 cgg cgc gaa ggc ctc act act gtg Arg Arg Giu Gly Leu Thr Thr Val 1 185 gcg ato toc atc got gao ogc ato c Ala Ile Ser Ile Ala Asp Arg Ile 200 205 caa cag gta goc acc cot act gag Gin Gin Val Ala Thr Pro Thr Giu 1 215 220 gat gtt gcc cga ttc atc gto g~c Asp Val Ala Arg Phe Ile Val Asp 1 230 235 <210> 524 <211> 239 <212> PRT <213> Corynebacterium giutamicum <400> 524 Val Ser Ser Ile Lys Leu Arg Asp 1 5 Thr Phe Giy Leu Gin Asp Ile Asn Val Val Leu Ile Gly Pro Ser Gly 40 Thr Ile Ala Gly Phe Vai Giu Pro 55 Gly Giu Giu Met Thr His Val Pro 70 Val Phe Gin Gin His Ala Val Trp Val Gly Tyr Pro Leu Ala Arg Ser 100 Lys Arg Val Giu Arg Thr Leu Ala 115 120 Ser Arg Arq Pro Ala Ser Leu Ser gtg Val1 gac Asp ogo Arg 175 gtg Val gta Val1 ct t Leu aco Thr gog Aila gag Giu 160 gaa Giu a cg Thr oto Le u too Ser gog Ala oto Leu gta Val gao Asp aac Asn 210 000 Pro ogo Arg too Ser tot Ser og o Arg 195 ggt Gi y got Al a goc ato Ala Ile goc oto Ala Leu 165 ttg aco Leu Thr 180 goc gaa Ala Giu oga ato Arg Ile act gc Thr Ala 547 595 643 691 739 787 Leu Ser Val Ser Phe Arg 10 Leu Lys Ile Giu Pro Glu 25 Ser Gly Lys Thr Thr Met Ser Ser Gly Ser Val Leu Pro Giu Arg Arg Arg Met 75 Pro His Met Ser Val Ala 90 Gly Gin Lys Gly Ala Ser 105 110 Leu Val Gly Leu Giu Gly 125 Gly Gly Gin Arg Gin Arg Asp Gly Glu Phe Leu Gly Ile Ala Gly Met Lys Asn Ile Ser Phe Gly Val Ala 135 140 Leu 145 Ala Arg Ala Ile Ala Asp Pro Thr Val1 155 Leu Len Len Asp Giu 160 Ala Len Ser Ala Leu 165 Asp Gin Pro Len Asp Ala Len Arg Arg Gin 175 Val Thr Len Val Ser Thr Arg Arg Gin Len Thr Thr Val His Asp Arg Ala Glu Ala Ile Ser Ile Ala Asp Arg 195 200 Ile 205 Val Val Leu Gly Asn 210 Gly Arg Ilie Gin Val Ala Thr Pro Gin Len Len Ser Ala 225 Pro Ala Thr Ala Val Ala Arg Phe Ile 235 Val Asp Ala Thr <210> 525 <211> 1653 <212> DNA <213> Corynebacterium glutamicum <221> CDS <222> (101)..(1630) <223> RXA02073 <400> 525 tcattgtttt agaggatggc caattqacca tqatqgatac acccagcaac gtttcccagc acaatgcgtt tttccgcacc gctgtgatgq aggaagaaca atg att tcc cga ctt Met Ile Ser Arg Len ctc caa ttg gct Leu Gin Len Ala aag Lys aaa qta tgg ccg Lys Val Trp Pro ctt gga gcc tcc Len Gly Ala Ser acg ctc Thr Len ctg cga ctg Leu Arg Len gcc tgg gtg Ala Trp Val aat cag cta ctc Asn Gin Len Len gca gca ctc att Ala Ala Len Ile gtg ttc ccc Val Phe Pro qcc gtc 9CC Ala Val Ala cta agc cgc aaa Leu Ser Arg Lys cca Pro gac atc tcc ctg Asp Ile Ser Len atc atc Ile Ile atg gcg ctc atc gcg ctg aca gca gct gtc tqt cgc tgg ggt Met Ala Len Ile Ala Len Thr Ala Ala Val Cys Arg Trp Gly gag Gin cag gta tgc qgc Gin Val Cys Gly cgc gct gcc ttt Arg Ala Ala Phe ggg Gly ctg ctt gcc cac Len Leu Ala His cgc gtt atg ctt Arg Val Met Len tac T yr gac gcc ctc gtc Asp Ala Len Val cac H is 95 aaa ggt tcc ccc Lys Gly Ser Pro tcg ccg Ser Pro 100 atc cac ggc aqc ggt tcg etc etg tct gtt gcc acc cgt gac att aec 451 Ile His Giy Ser Gly Ser Ile Met Ser Vai Ala Thr Arg Asp Ile Asn 105 110 115 tcc atc gaa gta ttc ttc gcg cec acc att ggg cct aca gtc acc gce 499 Ser Ile Giu Val Phe Phe Ala His Thr Ile Gly Pro Thr Val Thr Ala 120 125 130 gtg ctg ctc agt gcg gga ggc gtq etc acg ctg gca acg ctc gat ccc 547 Val Leu Leu Ser Ala Gly Gly Val Ile Thr Leu Ala Thr Leu Asp Pro 135 140 145 gtt gct ggt cte att ggt tta ctc ggt gtc ctc etc qcg tgq ttg etc 595 Val Ale Gly Leu Ile Gly Leu Leu Gly Val Leu Ile Ala Trp Leu Ile 150 155 160 165 ccc ttg att gga aae cee tcc tca agc egt gee gcc ace tca cgt gge 643 Pro Leu Ile Gly Lys Gin Ser Ser Ser Ser Giu Ale Thr Ser Arg Gly 170 175 180 cec etc gcc cag cec ctc acc gaa gat gcc gcc ggc egg ctt gee etc 691 His Ile Ale Gin His Leu Thr Glu Asp Ala Ala Gly Arg Leu Glu Ile 185 190 195 aac tca cat gga gcg caa gcc ace cgg tte aet gcg ctc gag gtg aaa 739 Asn Ser His Gly Ala Gin Ale Thr Arg Leu Asn Ale Leu Giu Val Lys 200 205 210 gag cee cee ctg gee cee gtt gtg acc cga ceg ggc ttg etc gtc ggt 787 Giu Gin Gin Leu Glu Gin Vai Val Thr Arg Gin Gly Leu Ile Val Gly 215 220 225 etc cgt ceg ggc gce gce ctt tta tgg ccg tgg ate tca gct gtg ttg 835 Ile Arg Gin Gly Ale Ala Leu Leu Trp Pro Trp Ile Ser Ala Val Leu 230 235 240 245 ttg gtt gct ctg gtt cct cat gtg ggc att gtt gce gcc gcg att etc 883 Leu Val Aie Leu Val Pro His Vei Giy Ile Val Ale Ala Ale Ile Ile 250 255 260 ctg ggc etc tcc cct gcg ttg get gce gtt gag gge ttt gct cgc ecc 931 Leu Gly Ile Ser Pro Ale Leu Asp Ala Vai Glu Gly Phe Ala Arg Thr 265 270 275 etg cct acc gcg tte eec egt gcg cag cgg tat ttc cag etc etc get 979 Met Pro Thr Ala Leu Asn Ser Ale Gin Arg Tyr Phe Gin Ile Ile Asp 280 285 290 gcc cct gtt gct etc gct gee cct gec gag ccg aeg cct ttg ccc eee 1027 Ala Pro Val Ala Ile Ala Giu Pro Asp Giu Pro Lys Pro Leu Pro Lys 295 300 305 ggc ccg ctt eag ctg cga ett tct aga gtt cce gtc egc gca aag ggc 1075 Gly Pro Leu Lys Leu Arg Ile Ser Arg Vel Pro Val Ser Ale Lys Giy 310 315 320 325 acc gtg tct tta gag gtt gce gct ggt gee cec etc ggc etc etc gga 1123 Thr Val Ser Leu Giu Val Ale Ale Gly Glu His Ile Gly Ile Ile Gly 330 335 340 tcc agc ggt Ser Ser Gly gcg caa cta Ala Gin Leu 360 agt Ser 345 gga aaa tcc act Gly Lys Ser Thr gcc aaa ctc atc Ala Lys Leu Ile ctc aag ctg Leu Lys Leu 355 gat atc gca Asp Ile Ala 1171 cgg tct gga acc Arg Ser Gly Thr atc Ile 365 acc atc ggt ggt Thr Ile Gly Gly 1219 gag gtt Giu Val 375 tca tcg gcg gag Ser Ser Ala Giu cgc aaa tcc gtc Arg Lys Ser Vai a cg Thr 385 ctg gtt gag cag Leu Val Giu Gin aaa Lys 390 tct gtg ctg ttt Ser Val Leu Phe gca agc gtg ctg Ala Ser Val Leu aat tta cgg atg Asn Leu Arg Met ggC Gly 405 1267 1315 1363 aat cca gag ctg Asn Pro Giu Leu gaa gat qaa gca Giu Asp Giu Ala a gq Arg 415 gaa gcc ttg agg Giu Ala Leu Arg ttg gcg Leu Ala 420 tcg ata agc Ser Ile Ser gga cag caa Gly Gin Gin 440 gaa Giu 425 ctg cct tta gat Leu Pro Leu Asp gac gcc ctg cgc Asp Ala Leu Arg cta tct ggc Leu Ser Giy 435 cgc acc cct Arg Thr Pro 1411 1459 caa cgg ctc tgc Gin Arg Leu Cys ct g Le u 445 gog cgt gct ttg Aia Arg Ala Leu cag gta Gin Val 455 ctg att gtc gat Le Ile Vai Asp gcc acc agc cac Ala Thr Ser His ca a Gin 465 gat gcg ctc aat Asp Ala Leu Asn caa Gin 470 gcg gat ctt tcc Ala Asp Leu Ser act ctg gcc acg Thr Len Ala Thr aaa. gac acc acg Lys Asp Thr Thr atc atc att gcg Ile Ile Ile Ala cgc aca gct gca Arg Thr Ala Ala tta Len 495 acc cat gtg gat Thr His Val Asp cgg ata Arg Ile 500 1507 1555 1603 1650 1653 att gac ctg Ile Asp Leu gaa Giu 505 gaa atc aaa aat Giu Ile Lys Asn ccc Pro 510 tgatccttaa cgcggatcag <210> 526 (211> 510 <212> PRT <213> Corynebacterium giutamicum <400> 526 Met Ile Ser Arg Len Leu Gin Leu Ala 1 5 Gly Ala Ser Thr Leu Leu Arg Len Leu 25 Len Ile Val Phe Pro Ala Trp Val Leu 40 Lys Val Trp Pro Gin Len Asn Gin Len Leu Thr Ala Ala Asp Ile Ser Ser Arg Lys Pro Leu Leu Ala Val Ala Ile Ile Met Ala Leu Ile Ala Leu Thr Ala Ala Val. Cys Leu Leu Gly Ser Thr Arg Pro Thr 130 Ala Thr 145 Ile Ala Ala Thr Gly Arg Ala Leu 210 Giy Leu 225 Ile Ser Ala Ala Gly Phe Phe Gin 290 Lys Pro 305 Val Ser Ile Gly Leu Ile Arg Ala Pro Asp 115 Val Leu Trp Ser Le u 195 Glu Ile Ala Ala Al a 275 Ile Leu Al a Ile Le u 355 Trp His Ser 100 Ile Thr As p Leu Arg 180 Giu Val Val1 Val1 Ile 260 Arg Ile Pro Lys Ile 340 Lys Giy Met Pro As n Al a Pro Ile 165 Gly Ile Lys Gly Leu 245 Ile Thr Asp Lys Gly 325 Gl y Leu Glu 70 Arg Ile Ser Val1 Val1 150 Pro His As n Glu Ile 230 Le u Leu Met Al a Gly 310 Thr Se r Al a 55 Gin Val1 His Ile Leu 135 Ala Leu Ile Ser Gin 215 Arg Val1 Gly Pro Pro 295 Pro ValI Ser Gin Val1 Met Giy Giu 120 Leu Gi y Ile Al a His 200 Gin Gin Al a Ile Thr 280 Val1 Le u Se r Gi y Leu 360 Cys be u Se r 105 Val1 Ser Leu Gly Gin 185 Gly Leu Gi y Le u Se r 265 Aia Al a Lys Leu Ser 345 Arq Gly T yr 90 Gly Phe Ala Ile Lys 170 H is Ala Glu Ala Val 250 Pro Leu Ile Leu Giu 330 Gly Se r His 75 Asp Ser Phe Gi y Gi y 155 Gin Leu Gin Gin Al a 235 Pro Al a As n Aia Arg 315 Val1 Lys Giy Arg Ala Ile Ala Gl y 140 Leu Se r Thr Al a Val 220 Leu His Leu Ser Giu 300 Ile Ala Ser Thr Ala Leu Met His 125 Val1 Leu Ser Glu Thr 205 Val1 Leu Val1 Asp Ala 285 Pro Ser Ala Thr Ile 365 Al a Val1 Ser 110 Thr Ile Giy Ser Asp 190 Arg Thr Trp Giy Ala 270 Gin Asp Arg Gly Leu 350 Thr Phe His Val1 Ile Thr Val1 Ser 175 Ala Le u Arg Pro Ile 255 Val Arg Glu Val1 Giu 335 Ala Ile Gly Lys Ala Gly Leu Leu 160 Giu Al a As n Gin T rp 240 Val Glu Tyr Pro Pro 320 His Lys Gi y Gly Val A5P Ile Ala Glu Val Ser Ser Ala Giu Leu Ary Lys Ser Val 370 375 380 Thr Leu Val Giu Gin Lys Ser Val Leu Phe Arg Ala Ser Val Leu Giu 385 390 395 400 Asn Leu Arg Met Gly Asn Pro Giu Leu Ser Giu Asp Giu Ala Arg Glu 405 410 415 Ala Leu Arg Leu Ala Ser Ile Ser Giu Leu Pro Leu Asp Ala Asp Ala 420 425 430 Leu Arg Leu Ser Gly Gly Gin Gin Gin Arg Leu Cys Leu Ala Arg Ala 435 440 445 Leu Ala Arg Thr Pro Gin Val Leu Ile Val Asp Giu Ala Thr Ser His 450 455 460 Gin Asp Ala Leu Asn Gin Ala Asp Leu Ser Gin Thr Leu Ala Thr Leu 465 470 475 480 Lys Asp Thr Thr Val Ilie Ile Ie Ala His Arg Thr Ala Ala Leu Thr 485 490 495 His Val Asp Arg Ile Ilie Asp Leu Giu Giu Ile Lys Asn Pro 500 505 510 <210> 52*7 <211> 1142 <212> DNA <213> Corynebacteriun giutamicum <220> <221> CDS <222> (1)..(1119) <223> RXA01399 <400> 527 att ctc agc ccc gca acc qca ctt qtc ctg gcg att gga ttg att gct 48 Ile Leu Ser Pro Ala Thr Ala Leu Val Leu Ala Ile Gly Leu Ile Ala 1 5 10 gct gca att atc cct ccc ctg ctt gct gct cgc gga gtt aaa aca gcc 96 Ala Ala Ilie Ilie Pro Pro Leu Leu Ala Ala Arg Gly Val Lys Thr Ala 25 gaa gcc cgg cgc gct gaa tcc agc gaa gcc tac ttg agt tcc ttg gat 144 Giu Ala Arg Arg Ala Giu Ser Ser Giu Ala Tyr Leu Ser Ser Leu Asp 40 cag gtg ctg tcc aac cag gcg gcg ctt cgt gtt cgt qgt gaa atg ccg 192 Gin Val Leu Ser Asn Gin Ala Ala Leu Arg Val Arq Gly Giu Met Pro 55 gcc gct ctg tcc aag gcg gat gtg gct gcg cgt tcc tat tct tct tca 240 Ala Ala Leu Ser Lys Ala Asp Val Ala Ala Arg Ser Tyr Ser Ser Ser 70 75 ctg gag gca ggc gcg aaa gac act gcc att qgc qca gcg agt tcc ctg 288 Leu Giu Ala Gly Aia Lys Asp Thr Ala Ilie Gly Ala Ala Ser Ser Leu tgg att cac Trp Ile His ctg tat gca Leu Tyr Ala 115 ttc act gtc att Phe Thr Val Ile gtg ctc atg gtt Val Leu Met Val tcc gcg tca Ser Ala Ser 110 gtg ttg gtg Val Leu Val gat gga agc cat tca ccg cag tgg ttt Asp Gly Ser His Ser Pro Gin Trp Phe ctg ctt Leu Leu 130 tca ctc gca gct Ser Leu Ala Ala ttc Phe 135 gag gct gtc tct Giu Ala Val Ser gt t Val1 140 ctc ccc gat gct Leu Pro Asp Ala att gct cgt acc Ile Ala Arg Thr gcc gca gat gcc Ala Ala Asp Ala agg agg ctt gcg Arg Arg Leu Ala atc tcg gcg ctg Ile Ser Ala Leu cca Pro 165 gaa tct gtc tct Giu Ser Val Ser ctt Leu 170 gag ctt cgc acg Giu Leu Arg Thr gcc tct Ala Ser 175 gac cag ccc Asp Gin Pro gac cta ggc Asp Leu Gly 195 tta cgc gcc gag Leu Arg Ala Giu cta gtt tat gga Leu Val Tyr Giy tgg gac agc Trp Asp Ser 190 cqa cat gaa Arg His Glu acg agc aac ctg Thr Ser Asn Leu gat Asp 200 ctc acc ttt ggt Leu Thr Phe Giy t ca Ser 205 atc atc Ile Ile 210 gca ccc tct gga Ala Pro Ser Gly ggc aaa acg acc Gly Lys Thr Thr ctg Leu 220 ctg ctc aca ctt Leu Leu Thr Leu gcg Ala 225 ggg ctg ttg gaa Giy Leu Leu Giu cgt gga ggc caa Arg Gly Gly Gin gtg Val1 235 ctt atc gac ggc Leu Ile Asp Gly acc Thr 240 aat cct tcc gag Asn Pro Ser Giu ttg Leu 245 aaa aac gcc gtg Lys Asn Ala Val ctg Leu 250 ttc agt cca gaa Phe Ser Pro Giu gat gcc Asp Ala 255 cac att ttt His Ilie Phe gaa gca acc Giu Ala Thr 275 acc act gtc cqa Thr Thr Val Arg aac tta gca ctc Asn Leu Ala Leu gga gca ccg Gly Ala Pro 270 gtt ggt ttg Vai Gly Leu gac gcg gaa atg Asp Ala Giu Met tcg atc ctg qaa Ser Ile Leu Glu cat His 285 tca gag Ser Glu 290 tgg gtt caa ggt Trp Val Gin Gly ccc gat ggt ctt Pro Asp Gly Leu act gtc ctt gat Thr Val Leu Asp ggt gcc gat agt Gly Ala Asp Ser ctc Leu 310 tcg gga ggt cag Ser Gly Gly Gin cgc Arg 315 cgc cgc ctg ctc Arg Arg Leu Leu ct t Le u 320 912 960 1008 gcc cgc gta cta Ala Arg Val Leu ct a Leo 325 agt gat gca cca Ser Asp Ala Pro ctg ctt ttg gat Leu Leu Leu Asp gaa ccc Giu Pro 335 acc gag cac ctc gac act gca ggC tCc tct gaa atc ttg tct atg ctg Thr Glu His Leu Asp Thr Ala Gly Ser Ser Giu Ile Leu Ser Met Leu 340 345 350 gcc tcc gat gaa ctc cct ggt aaa aga gct agg aga acc gta gtg att Ala Ser Asp Glu Leu Pro Gly Lys Arg Ala Arg Arg Thr Val Val Ile 355 360 365 gtg agg ca t gtg agg taattttgcc ccgctgtctt ctg Val Arg His Val Arg 370 <210> 528 (211> 373 <212> PRT <213> Corynebacterium glutamicum 1056 1104 1142 <400> 528 Ile Ala Glu Gin Al a Leu Trp Le u Leu Al a 145 Ile Asp Asp Le u Ala Ala Val1 Al a Glu Ile Tyr Le u 130 Ile Ser Gin Leu Ser Pro Ile Ile Arg Arg Leu Ser Leu Ser Ala Gly His Gly 100 Ala Asp 115 Ser Leu Ala Arq Ala Leu Pro Val 180 Gly Thr 195 Al a Pro Al a Asn Lys Ala Phe Gly Al a Thr Pro 165 Leu Ser Thr Pro Glu Gin Ala 70 Lys Thr Ser Al a Arg 150 Giu Arg Asn Al a Leu Ser Ala 55 Asp Asp Val1 His Ph e 135 Ala Ser Ala Leu Le u Le u Ser 40 Ala Val Thr Ile Se r 120 Gi u Al a Val1 Glu Asp 200 Va~l Leu Ala Ile Gly Leu Ile Ala Al a 25 Glu Le u Ala Al a Gly 105 Pro Al a Asp Se r As n 185 Leu 10 Ala Ala Arg Ala Ile 90 ValI Gin Val1 Ala Le u 170 Leu Thr Arg Tyr Val1 Arg 75 Gl y Leu Trp Ser Thr 155 Glu Val1 Phe Gly Leu Arg Ser Al a Met Phe Val1 140 Arg Leu Tyr Gly Val1 Ser Gly Tyr Ala Val1 Gly 125 Leu Arg Arg Gly Ser 205 Lys Se r Giu Ser Ser Se r 110 Val1 Pro Leu Thr Trp 190 Arg Thr Leu Met Ser Ser Ala Leu Asp Ala Ala 175 Asp His Al a Asp Pro Ser Leu Se r Val1 Ala Glu 160 Ser Ser Glu Ile Ile Ala Pro Ser Gly Thr Gly Lys Thr Thr Leu Leu Leu Thr Leu Ala Gly Leu Leu Glu Pro Arg Gly Gly Gin Val 225 230 235 Asn Pro Ser Glu Leu Lys Asn Ala Val Leu Phe 245 250 His Ile Phe Ala Thr Thr Val Arg Asp Asn Leu 260 265 Glu Ala Thr Asp Ala Giu Met Thr Ser Ile Leu 275 280 Ser Giu Trp Val Gin Gly Leu Pro Asp Gly Leu 290 295 Ser Gly Ala Asp Ser Leu Ser Gly Gly Gin Arg 305 310 315 Ala Arg Val Leu Leu Ser Asp Ala Pro Ile Leu 325 330 Thr Glu His Leu Asp Thr Ala Gly Ser Ser Giu 340 345 Ala Ser Asp Glu Leu Pro Gly Lys Arg Ala Arg 355 360 Val Arg His Val Arg 370 <210> 529 <211> 1368 <212> DNA <213> Corynebacterium giutamicun <220> <221> CDS <222> (1345) <223> RXA01339 <400> 529 gagaaggcgg aaccgaagga atcgaagaat atctctccgt gacacatgag ctgtecggtg aataacccga aggaaaaaac: ata gtt gcg cac aat gct gca ggt aca gca cet Ile Val Ala His Asn Ala Ala Giy Thr Ala Pro 15 get aag aag aag tac ctc age: gtt gce caa ggc Ala Lys Lys Lys Tyr Leu Ser Val Ala Gin Giy 30 gga acc aac ate gge gee ggt gtg etc age etc: Giy Thr Asn Ile Giy Ala Gly Val Leu Ser Leu 45 Leu Ser Al a Glu Gly 300 Arg Leu Ile Arg Gly Asp 255 Ala Gly Le u Le u Glu 335 Met Val gcqttacctc getttgecqt atg act ace gaa tea Met Thr Thr Glu Ser 1 eag aat gtg tcc tct Gin Asn Val Ser Ser gtt gee ctt ate tac Val Ala Leu Ile Tyr eca tac: get gee ege Pro Tyr Ala Ala Arg aac ggt ggt ttc cc gcc ctg gtt gtt 9cc ctg ctc Asn Gly Gly Phe Leu Ala Leu Vai Vai Ala Leu Leu 60 att qcg gga aca Ile Ala Gly Thr ctg Leu acc acc atc tcc Thr Thr Ile Ser ctc tac atc gc Leu Tyr Ile Ala gta tcc: ctg cgc Val Ser Leu Arg aag aag cca ctg S Lys Lys Pro Leu ctt tcC ggc ctg Leu Ser Gly Leu gca Ala gaa aaa tac ctg Glu Lys Tyr Leu ggg cag Gly Gin 100 tqg ggc cgC Trp Gly Arg gca ctg att Ala Leu Ile 120 ctg gtg ttC att Leu Val Phe Ile att gtg gtc aac Ile Val Vai Asn agc gtg gqt Ser Val Gly 115 ggc aac ctC Gly Asn Leu gcc tac gca tca Ala Tyr Ala Ser gga Gly 125 tcc ggc att ttg Ser Gly Ile Leu acc: ggc Thr Giy 135 ctg cca cca atC Leu Pro Pro Ile gtg Val1 140 ggc acc ctt gga Gly Thr Leu Gly ttt gtt tta ggc Phe Val Leu Giy acO Thr 150 ttg atC atg tgg Leu Ilie Met Trp ggc ctg cac acg Gly Leu His Thr aqc ttc gtq gag Ser Phe Val Giu gca Ala 165 ttg atC acc act Leu Ile Thr Thr atg gca acg atc Met Ala Thr Ile atc: Ile 175 atc gtg ctg tgt Ile Val Leu Cys gga tgg Gly Trp 180 aca gtg ctt Thr Val Leu cca ttc ttc Pro Phe Phe 200 cct gga att tcc Pro Gly Ile Ser gca Ala 190 gac aac ctg atc Asp Asn Leu Ile gtg ttc cac Val Phe His 195 acc ttc ctt Thr Phe Leu 691 739 atc gtt ccg atc Ile Val Pro Ile atg Met 205 aac ctc qcg gtc Asn Leu Ala Val gcc caa Ala Gin 215 tat gtg gtt cca Tyr Val Val Pro atc gca cga qga Ile Ala Arg Gly aac CCt gcc acc Asn Pro Ala Thr aag gca gtg cca Lys Ala Val Pro gcg atc atc atc Ala Ilie Ile Ile atg gtc gca act Met Val Ala Thr 787 835 883 gtc acc ctg gca Val Thr Leu Ala gta cca ttc gcg Val Pro Phe Ala gca Al a 255 cta ggg ctt ctg Leu Gly Leu Leu ggc aca Gly Thr 260 ggc gtc agt gaa gtt gtc acc atc Gly Val Ser Giu Val Val Thr Ile tqg ggc gaa gca Trp Gly Glu Ala ctc gcc cca Leu Ala Pro 275 atg ttc act Met Phe Thr qtg gcc tat Val Ala Tyr 280 tac atg gcc aat gcc ttc gca cta ttg Tyr Met Ala Asn Ala Phe Ala Leu Leu 285 gcc Al a 290 tca ttc atc gcc att gga ttc acc gcg atg cgc aac gta cta gat att 12 1027 Ser Phe Ile Ala Ile Gly Phe Thr Ala Met Arg Asn Val Leu Asp Ile 305 gqc Gly 310 act Thr gt g Val1 atc Ile gaa Giu Ctg Leu 390 295 cac His gt t Val 9 ca Ala atc Ile cca Pro 375 t tg Leu tgg Trp ct t Leu gca Al a ccc Pro 360 gtg Val1 att Ile cac His 315 ctg be u tac Tyr ttg be u gcc Al a tac Tyr 395 ca g Gin tca Ser ga Gi y 350 aac As n ca a Gin 9c9 Al a cga tcc Arg Ser 320 ctt gcg Leu Ala 335 ttt gcc Phe Ala tcc c Ser Arg qcg cac Ala His ttt gtg Phe Val 400 gtc Val1 Gi y atc Ile 355 ggc Gi y ttc Phe gtt cta Leu 325 ttc Phe tcc Ser caa Gin atc Ile 9C9 300 1075 1123 1171 1219 1267 1315 T-yr Ser Val Leu Ala atc gtc gga tta atg cct gcg ggt tgg gca tagtcacttc ctgttgtggc 1365 Ile Val Gly Leu Met 410 Pro Ala Gly Trp Ala t gc <210> 530 <211> 415 <212> PRT <213> Corynebacterium glutarnicum <400> 530 Met Thr Thr Giu Ser Ile Val Ala His 1 5 Gin Asn Val Ser Ser Ala Lys Lys Lys Val Ala Leu Ile Tyr Gly Thr Asn Ile Pro Tyr Ala Ala Arg Asn Gly Gly Phe Leu Ile Ala Gly Thr Leu Thr Thr Ile 70 Val Ser Leu Arg Thr Lys Lys Pro Leu Lys Tyr Leu Gly Gin Trp Gly Arq Trp 100 105 1368 Asn 10 Tyr Gly Leu Ser Gin 90 Leu Al a Leu Ala Al a Met Leu Val Ala Gin Ser Ala Ala Ala Ile Val Asn Ser Val Gly Ala Leu Ile Ala Tyr Ala Ser Gly Ser Gly Ile 115 120 125 Leu Ile Gly Asn Leu Thr Gly Leu Pro Pro Ile Val Gly Thr Leu Gly 130 135 140 Phe Phe Val Leu Gly Thr Leu Ile Met Trp Lys Gly Leu His Thr Ala 145 150 155 160 Ser Phe Val Glu Ala Leu Ile Thr Thr Gly Met Ala Thr Ile Ile Ile 165 170 175 Val Leu Cys Gly Trp Thr Val Leu Gly Pro Gly Ile Ser Ala Asp Asn 180 185 190 Leu Ile Val Phe His Pro Phe Phe Ile Val Pro Ile Met Asn Leu Ala 195 200 205 Val Phe Thr Phe Leu Ala Gin Tyr Val Val Pro Giu Ile Ala Arg Gly 210 215 220 Val Asn Pro Ala Thr Pro Lys Ala Val Pro Arq Ala Ile Ile Ile Gly 225 230 235 240 Met Val Ala Thr Gly Val Thr Leu Ala Ala Val Pro Phe Ala Ala Leu 245 250 255 Gly Leu Leu Gly Thr Gly Val Ser Glu Val Val Thr Ile Ser Trp Gly 260 265 270 Giu Ala Leu Ala Pro Val Ala Tyr Tyr Met Ala Asn Ala Phe Ala Leu 275 280 285 Leu Ala Met Phe Thr Ser Phe Ile Ala Ile Gly Phe Thr Ala Met Arg 290 295 300 Asn Val Leu Asp Ile Gly His Trp Pro Gin His Gly Trp Gin Arg Ser 305 310 315 320 Val Ala Val Gly Leu Thr Val Leu Pro Pro Leu Ala Ile Ser Leu Ala 325 6 330 335 Gly Leu Gly Gly Phe Val Ala Ala Leu Ser Tyr Ala Gly Gly ?he Ala 340 345 350 Gly Ala Ile Met Ser Ile Ile Pro Val Leu Leu Leu Arg Asn Ser Arg 355 360 365 Lys Ser Gly Asp Gin Glu Pro Val Trp Lys Ala Thr Trp Gin Ala His 370 375 380 Pro Ile Phe Gin Ile Leu Leu Ile Val Val Tyr Ser Leu Aia Phe Val 385 t 390 395 400 Tyr Ser Val Leu Ala Ile Val Gly Leu Met Pro Ala Gly Trp Ala 405 410 415 <210> 531 <211> 1452 <212> DNA <213> Corynebacterium giutamicum <z220> <221> <222> <223> C DS (101)..(1429) RXA02 527 <400> 531 attggagcaa tcttttaatc aagttgggaa ttccagcgtt ttgcccgcac cctgaagcac tcacggatca agcgtggcgg gattgtggtt gccatgtggt Met Phe Gly Leu Phe 1 atc gcg acg att Ile Ala Thr Ile gtg Val1 gcg att att cto Ala Ile Ile Leu cca atg cca atq Pro Met Pro Met ggt gcc Gly Ala gtg aca att Val Thr Ilie ttg acg gcg Leu Thr Ala ggc atg atc gcc Gly Met Ile Ala gtg ttg act ggt Val Leu Thr Gly ttg gtg ccg Leu Val Pro ctt att ggt Leu Ile Gly 211 259 tct tot gat gat Ser Ser Asp Asp CCC Pro 45 ggc gog gtq tat Gly Ala Val Tyr ggC Gly ttc agt Phe Ser aac ggc acc att Asn Gly Thr Ile ctg att gtg atg Leu Ile Val Met ttc ctg att tog Phe Leu le Ser gga ttc atc aaq Gly Phe Ile Ly5 ggg ctt gga ogt Gly Leu Gly Arg cga Ary ata gog ttg ttc Ile Ala Leu Phe ttt Phe gtg tct aaa gtc Val Ser Lys Val ggc Gly gga aaa atg ctg Giy Lys Met Leu ggt Gly 95 gtg acc tat ggt Val Thr Tyr Gly ttg gcg Leu Ala 100 ctc got gat Leu Ala Asp ggt ggt ggc Gly Gly Giy 120 gtg ttg got Oct Val Leu Ala Pro att oca tca gca Ile Pro Ser Ala act goc cga Thr Ala Arg 115 ttg act tat Leu Thr Tyr att atg got cog Ile Met Ala Pro atq aag tog gtg Met Lys Ser Vai gat too Asp Ser 135 act cot ggc ooa Thr Pro Gly Pro act Thr 140 cgt ogo agg got Arg Arg Arg Ala ggc Gly 145 gog ttc ttg gog Ala Phe Leu Ala oty Leu 150 aat gtg yya cag Asn Val Gly Gin gt a Val1 155 aat 909 att. acg Asn Ala Ile Thr 909 aty ttt cta Ala Met Phe Leu 547 595 643 gca atq gca gga Ala Met Ala Gly ccc ttg ato gcc Pro Leu Ile Ala ttg got tog cag Leu Ala Ser Gin atg gat Met Asp 180 gtc aat ato Val Asn Ile a og Th r 185 tgg aca aao tgg Trp Thr Asn Trp got Al a 190 gtg ggt gog att Val Gly Ala Ile gtg cot ggt Val Pro Gly 195* ctg gtg gcg Leu Val Ala 200 ctt att gtg gtg Leu Ile Val Val ccg Pro 205 tgg gtg gta tac Trp Val Val Tyr atc tat cca Ile Tyr Pro cct gag Pro Giu 215 ttg aag gac acc Leu Lys Asp Thr cct Pro 220 gag gtc aag aaa Glu Val Lys Lys gct tct gat gag Ala Ser Asp Glu aag caa ttg ggt Lys Gin Leu Gly ggg Gly 235 ttt act tat ggt Phe Thr Tyr. Gly gag Giu 240 aag gtg ctg gcg Lys Val Leu Ala acc ttt gtt gtg Thr Phe Val Val ctg ctg ctc tg Leu Leu Leu Trp ggt ggc gat ttg Gly Gly Asp Leu gtc ttg Val Leu 260 gqa atc tcg Gly Ile Ser gtq gct cac Val Ala His 280 gca Ala 265 act acc acc gct Thr Thr Thr Ala gtt ggc gtc atc Val Gly Val Ile atc ttg cta Ile Leu Leu 275 aag act gcg Lys Thr Ala gtg ctg acg tgg Val Leu Thr Trp gac atc att caa Asp Ie Ile Gin gaa Giu 290 tgg gac Trp Asp 295 acc atg gtg tgg Thr Met Val Trp ttc Phe 300 gcg gtg cta tac Ala Val Leu Tyr atg gca aca gcg Met Ala Thr Ala tta Leu 310 tcg cag tac gga Ser Gin Tyr Giy ttc Phe 315 atc gca tgg atc Ile Ala Trp Ile tct Ser 320 gag gta att gct Giu Val Ile Ala 931 979 1027 1075 1123 1171 1219 agt ttg ggt ggc Ser Leu Gly Gly aac tgg gtc gtt Asn Trp Val Val ttg gtt gtg ttg Leu Val Val Leu gtg ctg Val Leu 340 att tac ttc Ile Tyr Phe tct gcg atg Ser Ala Met 360 agt cac tat ttc Ser His Tyr Phe gqc tcg gca aca Ala Ser Ala Thr gcg cat att Ala His Ile 355 att ggt gca Ile Gly Ala tac ttg gcc ttc Tyr Leu Ala Phe ggt gct gcg att Gly Ala Ala Ile gcg Ala 370 ccc ccg Pro Pro 375 ttg atg gcg gcc Leu Met Ala Ala gtg ttg gcg tac Val Leu Ala Tyr acc Thr 385 tcc aat ttg ttc Ser Asn Leu Phie t ct Ser 390 tca ctc act cag Ser Leu Thr Gin tct ggt ggt cct Ser Gly Gly Pro cca aca ttg ttt Pro Thr Leu Phe 1267 1315 1363 ttg aac tac atc Leu Asn Tyr Ile a cg Thr 410 gtg ggt gag tgg Val Gly Giu Trp cgg acc tcg gca Arg Thr Ser Ala att gct Ile Ala 420 ggc gcg gta Gly Ala Val att aca atc tgg Ile Thr Ile Trp gtt atc ggt ggt Val Ile Gly Gly ttg tgg atg Leu Trp Met 435 1411 aat gtc ate gga ctc tgg taatcgaaaa ttaaaggtaa ggg 1452 Asn Val Ile Gly Leu Trp 440 fl <210> 532 <211> 443 <212> PRT j- <213> Corynebacterium qiutamicum <400> 532 Met Phe Gly Leu Phe Ile Ala Thr Ile Val Ala Ile Ile Leu Lys Pro tl 1 5 10 Met Pro Met Gly Ala Val Thr Ile Ile Gly Met Ile Ala Ala Val Leu 25 IND Thr Gly Leu Vai Pro Leu Thr Ala Ser Ser Asp Asp Pro Giy Ala Val 40 Tyr Gly Leu Ile Giy Phe Ser Asn Gly Thr Ile Trp Leu Ile Val Met 5S Ala ?he Leu Ile Ser Arg Giy The Ile Lys Thr Giy Leu Gly Arg Arg 70 75 Ile Ala Leu Phe Phe Vai Ser Lys Val Gly Giy Lys Met Leu Giy Val 90 Thr Tyr Giy Leu Ala Leu Ala Asp Leu Val Leu Ala Pro Ala Ile Pro 100 105 110 Ser Ala Thr Ala Arg Gly Gly Gly Ile Met Ala Pro Ile Met Lys Ser 115 120 125 Val Ala Leu Thr Tyr Asp Ser Thr Pro Gly Pro Thr Arq Arg Arg Ala 130 135 140 Gly Ala Phe Leu Ala Leu Asn Val Gly Gin Val Asn Ala Ile Thr Cys 145 150 155 160 Ala Met Phe Leu Thr Ala Met Ala Gly Asn Pro Leu Ile Ala Ser Leu 165 170 175 Ala Ser Gin Met Asp Val Asn Ile Thr Trp Thr Asn Trp Ala Val Gly 180 185 190 Ala Ile Val Pro Gly Leu Val Ala Leu Ile Val Val Pro Trp Val Val 195 200 205 Tyr Lys Ile Tyr Pro Pro Glu Leu Lys Asp Thr Pro Glu Val Lys Lys 210 215 220 Met Ala Ser Asp Giu Leu Lys Gin Leu Gly Gly Phe Thr Tyr Gly Giu 225 230 235 240 Lys Val Leu Ala Gly Thr Phe Val Val Leu Leu Leu Leu Trp Thr Gly 245 250 255 Gly Asp Leu Val Leu Gly Ile Ser Ala Thr Thr Thr Ala Phe Val Gly 260 265 270 Val1 Gin Met 305 Glu Val1 Ala Ile Thr 385 Pro Thr Gly Ile Glu 290 Met Val1 Val1 Thr Ala 370 Ser Thr Se r Gly Ile 275 Lys Al a Ile Le u Al a 355 Ile Asn Leu Ala Leo 435 Leu Ala Al a Ser 325 Leu Ile Ala Phe Gly 405 Ala Val1 Trp Leu 310 Ser Ile Ser Pro Ser 390 Leu Gly Val1 Met Tyr Gi y Phe 345 T yr Met Thr Ile Ser 425 Thr Trp Phe 315 As n His Ala Al a Tyr 395 Val1 Thr Trp Phe 300 Ile Trp Tyr Phe Le u 380 Ser Gi y Ile Glu 285 Ala Ala Val1 Phe Leo 365 Val1 Gly Glu Trp Asp Val1 T rp Val1 Phe 350 Gi y Leu Gi y Trp Leo 430 Ile Leo Ile Al a 335 Ala Ala Ala Pro T rp 415 Val1 Trp Met Asn Val Ile Gly Leu Trp 440 <210> S33 <211> 1968 <212> DNA <213> Corynebacterium glutamicrn <220> <221> CDS <222> (101)..(1945) <223> RXN00298 <400> 533 tttagacaag ttctggttaa aattcttcat gaaggtgaga tctttcagat tcgtagttat ccactqattg gaagaatgag gct atc acg acc gag cct gaa ggg aaa aat aaa Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys 15 gac ccg ttc att ttt tcc att tct gtc ggt ttt Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe 30 atc gcc aca att gcg cta ggc gag aaa gct cga atctgggaat ttctcggtac atg agc tca aat ata 115 Met Ser Ser Asn Ile 1 aag ggt ctc aaa tca 163 Lys Gly Leo Lys Ser atc gtg gtg ttt gtc 211 Ile Val Val Phe Val aca acc ttt tcc gcg 259 Ile Ala Thr Ile Ala Leu Gly Lys Ala Arg Thr Thr Phe Ser Ala att gc Ile Ala ggo tgg ctc tta Gly Trp Leu Leu aat tta ggg tgg Asn Leu Gly Trp tat atc ggg ggt Tyr Ilie Gly Gly gtc Val tcc ttg gtt ttc: Ser Leu Val Phe att Ile ttc ctc atg ggt Phe Leu Met Gly ttt gcg tcc cgg Phe Ala Ser Arg 307 355 403 ggc cgg gta aaa Gly Arg Val Lys gqt gat gac gat Gly Asp Asp Asp gat Asp gac ccc gag cac Asp Pro Glu His acc cta Thr Leu 100 atc gtg tgg Ile Val Trp atg ttt tgg Met Phe Trp 120 tgt atg ott ttt Cys Met Leu Phe ggc ggt gtc ggt Gly Gly Val Gly gca gtc tta Ala Val Leu 115 aac gtg cca Asn Val Pro ggt gtt goc gaa Gly Val Ala Glu att aao cac gog Ile Asn His Ala ttc Phe 130 atg gct Met Ala 135 aat gaa gaa tco Asn Glu Glu Ser agt gaa goc gca Ser Giu Ala Ala gtq cag got ttt Vai Gin Ala Phe tat act ttc tat Tyr Thr Phe Tyr cao: His 155 ttc ggt att oac Phe Gly Ile His tgg gta ato atg Trp Val Ile Met ctc cca gga tta Leu Pro Gly Leu tca Ser 170 ttg gga tao ttt Leu Gly Tyr Phe tao aaa cgt aag Tyr Lys Arg Lys cta cot Leu Pro 180 ccc ogt cta Pro Arg Leu tcc aca ccc Ser Thr Pro 200 tot gtg ttt tct Ser Val Phe Ser atc ttg ggt aaq Ile Leu Gly Lys cac att tat His Ile Tyr 195 gqc acc acq Gly Thr Thr 691 739 ggc aag cto ato Gly Lys Leu Ile gta ctg gcc atc Val Leu Ala ile gta Val1 210 ttt ggt Phe Gly 215 att gct gtg tca Ile Ala Val Ser ggt ctt ggt gtg Gly Leu Gly Val caa ato aat qoa Gin Ile Asn Ala gqt Gly 230 atg aac aaa ota Met Asn Lys Leu tgg T rp 235 ago aco cog caa Ser Thr Pro Gin tcg tgg gtt cag Ser Trp Val Gin Ott Le u 245 ttg ato ato ttg Leu Ile Ile Leu ato aco gog gtt Ile Thr Ala Val gca Ala 255 tgt att too gtt Cys Ile Ser Val got too Ala Ser 260 ggt ttg gat Gly Leu Asp aag Lys 265 ggc att aag tta Gly Ile Lys Leu otg Leu 270 tcc aac att aat Ser Asn Ile Asn att qca atg Ile Ala Met 275 goc gtt gog ttg atg ttc ttc ato ttg ttc act ggt oca aco cto aca Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr Gly Pro Thr Leu Thr 280 ttg ctg Leu Leu 295 cgc ttt ctc gta Arg Phe Leu Val tcc ttc gga atC Ser Phe Gly Ile tat Tyr 305 gca tcc tgg atg Ala Ser Trp Met aat ctg atg ttt Asn Leu Met Phe act gac tct ttc Thr Asp Ser Phe caa Gin 320 gat aac cca ggc Asp Asn Pro Gly 1027 1075 1123 cag ggc aaa tgg Gin Giy Lys Trp acg Thr 330 gtg ttc tat tgg Val Phe Tyr Trp tgg act att tgt Trp Thr Ile Cys tgg tog Trp Ser 340 cca tat gtc Pro Tyr Val cgt gaa ttt Arg Giu Phe 360 atg ttc gtg gog M'et Phe Val Ala att tcg ogt gga Ile Ser Arg Giy cgt acc gtc Arg Thr Vai 355 ttt ggc gta Phe Gly Val 1171 1219 atc ggt ggg gtt Ile Giy Giy Val got otg cca gcg Ala Leu Pro Ala atc Ile 370 gtt tgg Val Trp, 375 tto tct atc ttt Phe Ser Ile Phe ggt Giy 380 cgt gca ggc atc Arq Ala Gly Ile gtg gaa otg agt Val Giu Leu Ser coB ggt ttc ttg Pro Gly Phe Leu cag cca act gtt Gin Pro Thr Val gt t Val1 400 gaa ggt gac gtg Giu Gly Asp Val o ca Pro 405 goa gcg ctt ttt Ala Ala Leu Phe aat Asn 410 gtg ctg caa gag Val. Leu Gin Glu tat Tyr 415 cog otg act gga Pro Leu Thr Gly att gtc Ile Val 420 1267 1315 1363 1411 1459 too gog ttt Ser Ala Phe gat too gca Asp Ser Ala 440 Ott gta att att Leu Val Ile Ile gtg Val 430 att tto ttt ato Ile Phe Phe Ilie aoo too atc Thr Ser Ile 435 gca gaa aat Ala Giu Asn gog ota gtt aac Ala Leu Val Asri atg tto got aco Met Phe Ala Thr caa aca Gin Thr 455 cog act agt tao Pro Thr Ser Tyr gtg atg tgg gc Val Met Trp Ala tgo Cys 465 aco att qgg gog Thr Ile Gly Ala gt 0 ValI 470 goa ggt too ttg Ala Gly Ser Leu ctg Le u 475 ato att too oca Ile Ile Ser Pro tot ggt att gc Ser Gly Ile Ala 1507 1555 1603 ctg oaa gaa gtg Leu Gin Glu Val atc ato gtg got Ile Ile Val Ala coa ttc ttc oto Pro Phe Phe Leu gtg caa Val Gin 500 ttt gto atg Phe Val Met gog gtt ogt Ala Val Arg 520 ttt tot ttg ott ?he Ser Leu Leu ggc atg agt gaa Gly Met Ser Giu gat got got Asp Ala Ala 515 gat aca oca Asp Thr Pro 1651 1699 cgt gtg oag act Arg Val Gin Thr cag tgg gaa aag Gin Trp Giu Lys act Thr 530 gaa aaa ctt gaa gag cat tcg tcc caa Glu Lys Leu Glu GJlu His Ser Ser Gin 535 540 gag ggc aac ccc ttg cca. atg cct 9CC Glu Gly Asn Pro Leu Pro Met Pro Ala 550 555 aac att gtt atc cca ggc aac gta gtc Asn Ile Val Ile Pro Gly Asn Val Val 570 gtt ggt gat gtg gtc gac gat cct gag Val Gly Asp Val Val Asp Asp Pro Glu 585 590 cgt ttt aag atc gtc gag caa act cgg Arg Phe Lys Ile Val Glu Gin Thr Arq 600 605 gat att taaacgattg cttttcgacg cac Asp Ile 615 <210> 534 <211> 615 <212> PRT <213> Corynebacterium giutamicum <400> 534 Met Ser Ser Asn Ile Ala Ile Thr Thr cca Pro ctc Leu att Ile 575 gaa Giu ccc Pro ggC Gly gat Asp gat Asp gag Glu a gg Arg 610 tat Tyr gag Glu ctt Leu atg Met 595 gac Asp gac Asp ggt Gly 565 gta Val1 tct Ser tac: Tyr 1747 1795 1843 1891 1939 1968 1 Lys Ile Thr Met Phe Pro Val1 Al a Gly Val1 Thr Tyr Ala Glu Gly Phe 130 Le u Val1 Phe Ile Ser His Al a 115 Asn Asp Ile Ile Val1 70 Gly Ile Met Met Pro Al a Ala 55 Ser Arg Val1 Phe Al a 135 Phe Thr 40 Gly Leu Val Trp Trp 120 Asn Ile Ile T rp Val1 Lys Phe 105 Gly Glu Glu 10 Phe Ala Leu Phe Leu Cys ValI Glu Pro Ser Leu Leu Ile 75 Gi y Met Al a Ser His 155 Glu Ile Giy Glu Phe Asp Leu Glu Met 140 Ph e Gly Ser Glu Asn Leu Asp Phe Pro 125 Ser Gly Lys Val1 Lys Leu Met Asp Ala 110 Ile Glu Ile Asri Gly Al a Gi y Gly Asp Gi y As n Al a His Lys Phe Arg Trp Ile Asp Gly His Ala Met 160 Ile Val Gin Ala Phe Ala Tyr Thr Phe Tyr Trp Lys Gly Ile Leu 225 Ser Ile Ile Gly Tyr 305 Asp Thr Arg Ala Giu 385 Glu Leu Phe Thr Cys 465 Val Arg Lys Val1 210 Gin Trp Ser Asn Pro 290 Ala As n Ile Giy Ile 310 Val1 Gly Thr Ile Gly 450 Thr Ile Lys His 195 Giy Ile Val Val Ile 275 Thr Ser Pr 0 Cys Arg 355 Phe Giu Asp Gly Thr 435 Al a Ile Met Ala Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr 165 170 175 Leu 180 Ile Thr Asn Gin Ala 260 Ala Leu Trp Gly Trp 340 Thr Gly Leu Val1 Ile 420 Ser Glu Gly Pro Tyr Thr Ala Leu 245 Ser Met Thr Met Trp 325 Ser Val1 ValI Ser Pro 405 Val2 Ile Asn Al a Pro Ser Phe Gly 230 Le u Gl y Al a Le u Pro 310 Gin Pro Arg Val1 Asn 390 Ala Ser Asp Gin Val1 470 Arg Thr Gly 215 Met Ile Leu Val1 Leu 295 Asn Gly Tyr Glu Trp 375 Pro Al a Ala Ser Thr 455 Ala Le u Pro 200 Ile Asn I).e Asp Ala 280 Arg Leu Lys Val1 Phe 360 Phe Gly Leu Phe Ala 440 Pro Gi y Se r 185 Giy Al a Lys Leu Lys 265 Leu Phe Met Trp Gly 345 Ile Ser Ph e Phe Ala 425 Al a Thr Ser Ser Val Lys Leu Val Ser Leu Trp 235 Ile Ile 250 Gly Ile Met Phe Leu Val Phe Trp 315 Thr Val 330 Met Phe Gly Gly Ile Phe Leu Thr 395 Asn Val 410 Leu Val Leu Val Ser Tyr Leu Leu 475 Phe Ile Val1 220 Ser Thr Lys Phe Giu 300 Th r Phe Val1 Val1 Gly 380 Gin Leu Ile Asn Arq 460 Ile Ser Asp 205 Gly Thr Al a Le u Ile 285 Ser Asp T yr Ala Leu 365 Arg Pro Gin Ile Asp 445 Val1 Ile Pro 190 Val1 Le u Pro Val1 Leu 270 Leu Ph e Ser Tip Arg 350 Al a Al a Thr Glu Val 430 Met Met Ser Ile Leu Gly Gln Al a 255 Se r Phe Gly Phe Ala 335 Ile Leu Gly Val1 Tyr 415 Ile Phe Trp Pro Leu Al a Val1 Val1 240 Cys As n Thr Ile Gin 320 Trp Ser Pro Ile Val1 400 Pro Phe Al a Al a Ser 480 Ser Gly Ilie Ala Thr Leu Gin Giu Val Val Ile 485 490 Phe Phe Leu Val Gin Phe Val Met Met Phe Ser 500 505 Ser Glu Asp Ala Ala Ala Val Arg Arg Val Gin 515 520 Lys Thr Asp Thr Pro Giu Lys Leu Giu Giu His 530 535 Pro Gly Tyr Asp Asp Glu Gly Asn Pro Leu Pro 545 550 555 His Asp Glu Asp Gly Asn Ile Val Ilie Pro Gly 565 570 Gly Asp Leu Gly Val Val Gly Asp Val Val Asp 580 585 Gin Glu Met Gly Ser Arg Phe Lys Ile Val Giu 595 600 Ser Arg Asp Glu Tyr Asp Ile 610 615 <210> 535 <211> 1968 <212> DNA <213> Corynebacteriun giutamicun <220> <221> CDS <222> (101)..(1945) <223> FRXA00298 <400> 535 tttaqacaag ttctggttaa aattctteat gaaggtgaga tetttcagat tcgtagttat ccactgattg gaagaatgag Ile Leu Thr Ser 540 Met Asn Asp Gin Val1 Leu Arg 525 Ser Pro Val1 Pro Thr 605 Phe 495 Gi y Trp Pro Leu Ile 575 Giu Pro Pro Met Glu Al a Glu 560 Glu Ala Gin ate Ile ceg Pro 9CC Ala gcc Al a a cg Thr ttc Phe aca Thr ggC Gi y gag Giu ttt Phe geg Ala etc Leu cct Pro tee Ser eta Le u tta Leu 9g9 Cly tct Se r gag Glu 45 aat As n aaa Lys gtc Val1 aaa Lys tta Leu aaa Lys ttt Phe cga. Arg tgg Trp atctgggaat ttctcggtae atq age tca aat ata Met Ser Ser Asn Ile 1 aag ggt ctc aaa tca Lys G1.y Leu Lys Ser ate gtg gtg ttt gtc Ile Vai Val Phe Val aca ace ttt tec gcg Thr Thr Phe Ser Ala atg tat ate ggg ggt Met Tyr Ile Gly Gly gtc Val1 toc ttg gtt tto Ser Leu Val Phe ttc cto atg ggt Phe Leu Met Gly ttt gog too cgg Phe Ala Ser Arg ggc cgg gta aa Gly Arg Val Lys ct t Le u ggt gat gao gat Gly Asp Asp Asp gac ccc gag cac Asp Pro Giu His acc cta Thr Leu 100 atc gtg tgg Ile Val Trp atg ttt tgg Met Phe Trp 120 tgt atg ott ttt Cys Met Leu Phe ggc ggt gtc ggt Giy Gly Val Gly gca gtc tta Ala Val Leu 115 aac gtg cca Asn Val Pro ggt gtt goc gaa Gly Val Ala Glu cog Pro 125 att aac cac gog Ile Asn His Ala atg got Met Ala 135 aat gaa gaa too Asn Glu Giu Ser agt gaa goc gca Ser Glu Ala Ala gtg oag got ttt Val Gin Ala Phe tat act ttc tat Tyr Thr Phe Tyr ttc ggt att cac Phe Gly Ile His atg Met 160 tgg gta atc atg Trp Val Ile Met 547 595 643 otc ooa gga tta Leu Pro Gly Leu ttg gga tao ttt Leu Gly Tyr Phe tao aaa ogt aag Tyr Lys Arg Lys Ota cot Leu Pro 180 000 ogt ota Pro Arg Leu too aca ccc Ser Thr Pro 200 too Ser 185 tot gtg ttt tot Ser Val Phe Ser ato ttg ggt aag Ile Leu Gly Lys oaoc att tat His Ile Tyr 195 ggc acc acg Giy Thr Thr ggo aag ctc atc Gly Lys Leu Ile gta otg goc ato Val Leu Ala Ile gta Val1 210 ttt ggt Phe Gly 215 att got gtg toa Ile Ala Val Ser ggt ott ggt gtg Gly Leu Gly Val ot g Le u 225 caa ato aat gca Gin Ile Asn Ala ggt Gi y 230 atg aao aaa ota Met Asn Lys Leu ago aoo cog caa Ser Thr Pro Gin tog tgg gtt cag Ser Trp Vai Gin 787 835 883 ttg ato ato ttg Leu Ilie Ile Leu atc Ile 250 ato aoc gog gtt Ile Thr Ala Val tgt att too gtt Cys Ilie Ser Val got tcc Ala Ser 260 ggt ttg gat Gly Leu Asp qco gtt gog Ala Val Ala 280 ggo att aag tta Gly Ile Lys Leu too aac att aat Ser Asn Ile Asn att goa atg Ile Ala Met 275 aoo oto aoa Thr Leu Thr ttg atq tto ttc Leu Met Phe Phe ttq tto act qgt Leu Phe Thr Gly oca Pro 290 ttg ctg Leu Leu 295 ogo ttt oto gta Arg Phe Leu Val gaa Giu 300 too ttc gga ato Ser Phe Gly Ile goa too tgg atg Ala Ser Trp Met 1027 cot aat ctg atg ttt tgg act gac tct ttc caa gat aac cca ggc tgg 17 1075 Pro 310 Asn Leu Met Phe Thr Asp Ser Phe Gin 320 Asp Asn Pro Gly Trp 325 cag ggc aaa tgg Gin Gly Lys Trp acg Thr 330 qtg ttc tat tgg Val Phe Tyr Trp tgg act att tqt Trp Thr Ile Cys tgg tcg Trp Ser 340 1123 cca tat gtc Pro Tyr Val cgt gaa ttt Arg Giu Phe 360 atg ttc gtg gcg Met Phe Val Ala att tcg cgt gga Ile Ser Arg Gly cgt acc gtc Arg Thr Val 355 ttt ggc gta Phe Gly Val 1171 1219 atc ggt ggg gtt Ile Gly Gly Val cta Leu 365 gct ctg cca gcg Ala Leu Pro Ala gtt tgg Val Trp 375 ttc tct atc ttt Phe Ser Ile Phe cgt gca ggc atc Argj Ala Gly Ile gtg gaa ctg agt Val Glu Leu Ser aac Asn 390 cca ggt ttc ttg Pro Gly Phe Leu cag cca act gtt Gin Pro Thr Val gt t Val1 400 gaa ggt gac gtg Glu Gly Asp Val 1267 1315 1363 gca gcg ctt ttt Ala Ala Leu Phe gtg ctq caa gag Val Leu Gin Glu tat Tyr 415 ccg ctg act gga Pro Leu Thr Gly att gtc Ile Val 420 tcc gcq ttt Ser Ala Phe gat tcc gca Asp Ser Ala 440 ctt gta att att. Leu Val Ile Ile att ttc ttt atc Ile Phe Phe Ile acc tcc atc Thr Ser Ile 435 gCa gaa aat Ala Glu Asn gcg cta gtt aac Ala Leu Val Asn atg ttc gct acc Met Phe Ala Thr ggt Gly 450 caa aca Gin Thr 455 ccg act agt tac Pro Thr Ser Tyr cgc Arg 460 gtg atg tgg gcc Val Met Trp Ala t gc Cys 465 acc att ggg gcg Thr Ile Gly Ala gtc Vali 470 gca ggt tcc ttg Ala Gly Ser Leu ctg Leu 475 atc att tcc cca Ile Ile Ser Pro tcc Ser 480 tct ggt att gcc Ser Giy Ile Ala a cq Thr 485 1411 1459 1507 1555 1603 1651 1699 ctg caa gaa gtg Leu Gin Giu Val atc atc gtg gct Ile Ile Val Ala ttc Phe 495 cca ttc ttc ctc Pro Phe Phe Leu gtg caa Val Gin 500 ttt gtc atg Phe Val Met gcg gtt cgt Ala Val Arg 520 ttt tct ttg ctt Phe Ser Leu Leu ggc atg agt gaa Gly Met Ser Glu gat gct. gct. Asp Ala Ala 515 gat aca cca Asp Thr Pro cgt gtg cag act Arg Val Gin Thr cg t Arg 525 cag tgg gaa aag Gin Trp Giu Lys act Thr 530 gaa aaa Glu Lys 535 ctt gaa gag cat Leu Glu Glu His tcc caa cca gcc Ser Gin Pro Ala ggc tat gat gac Gly Tyr Asp Asp 1747 gag ggc aac ccc ttg cca atg cct gcc ctc gaa cat gat gag gac ggt. Giu Giy Asn Pro Leu Pro Met Pro Ala Leu Giu His Asp Giu Asp Gly 1795 550 555 560 565 aac att gtt atc cca. ggc aac gta gtc att gaa ggt gat ctt ggg gta Asn Ile Val Ile Pro Giy Asn Vai Vai Ile Giu Gly Asp Leu Gly Vai 570 575 580 gtt ggt gat gtg gtc gac gat cct gag gaa gcc caa gag atg ggg tct Vai Gly Asp Vai Vai Asp Asp Pro Giu Giu Ala Gin Giu Met Giy Ser 585 590 595 cgt ttt aag atc gtc gag caa act cgg ccc cag tcc aqg gac gaa tac Arg Phe Lys Ile Val Glu Gin Thr Arg Pro Gin Ser Arg Asp Giu Tyr 600 605 610 gat att taaacgattg cttttcgacg cac Asp Ile 615 536 <211> 615 <212> PRT <2i3> Corynebacterium giutarnicum <400> 536 Met Ser Ser Asn Ile Ala Ile Thr Thr Giu Pro Glu Gly Lys Asn Lys 1843 1891 1939 1968 1 Lys Ile Thr Met Phe Pro Val1 Ala Ile 145 T rp Lys Gly Val1 Thr Tyr Ala Giu Giy Phe 130 Vali Val Arg Leu Val1 Phe Ile Ser His Ala 115 Asn Gin Ile Lys Lys Phe Ser Gly Arg Thr 100 Val1 Val1 Ala Met Leu 180 5 Ser Val1 Ala Gly T yr Leu Leu Pro Phe Ala 165 Pro Asp Ile Ile ValI 70 Gly Ile Met Met Ala 150 Leu Pro Pro Ala Ala 55 Ser Arg Val Phe Ala 135 T yr Pro Arg Phe Th r 40 Gly Le u Val Trp Trp 120 Asn Thr Gly Leu Ile 25 Ile Trp Val1 Lys Phe 105 Gly Giu Phe Leu Ser 185 Phe Ala Leu Phe Leu 90 Cys Val1 Glu Tyr Ser 170 Ser Ser Le u Leu Ile 75 Gly Met Al a Ser His 155 Leu Val1 Ile Gly Glu Phe Asp Leu Glu Met 140 Phe Gly Phe Ser Giu As n Leu Asp Phe Pro 125 Ser Gly T yr Ser Val1 Lys Leu Met Asp Ala 110 Ile Glu Ile Phe Pro 190 Gly Ala Gly Gly Asp Gly Asn Ala His Ile 175 Ile Phe Ar g Trp Ile Asp Gly His Al a Met 160 Tyr Leu Gly Lys His Ile Tyr Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala 195 200 205 Ile Val Gly Thr Thr Phe Gly Ile Ala Val Ser Val Gly Leu Giy Val 210 215 220 Leu Gin Ile Asn Ala Gly Met Asn Lys Leu Trp Ser Thr Pro Gin Val 225 230 235 240 Ser Trp Val Gin Leu Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys 245 250 255 Ile Ser Val Aia Ser Giy Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn 260 265 270 Ile Asn Ilie Aia Met Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr 275 280 285 Gly Pro Thr Leu Thr Leu Leu Arg Phe Leu Val Giu Ser Phe Gly Ile 290 295 300 Tyr Ala Ser Trp Met Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gin 305 310 315 320 Asp Asn Pro Giy Trp Gin Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp 325 330 335 Thr Ilie Cys Trp Ser Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser 340 345 350 Arg Gly Arg Thr Val Arg Giu Phe Ile Gly Gly Val Leu Ala Leu Pro 355 360 365 Ala Ile Phe Gly Val Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile 370 375 380 Giu Val Giu Leu Ser Asn Pro Gly Phe Leu Thr Gin Pro Thr Val Val 385 390 395 400 Giu Giy Asp Val Pro Ala Ala Leu Phe Asn Val Leu Gin Giu Tyr Pro 405 410 415 Leu Thr Gly Ile Val Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe 420 425 430 Phe Ilie Thr Ser Ilie Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala 435 440 445 Thr Giy Ala Giu Asn Gin Thr Pro Thr Ser Tyr Arg Val Met Trp Ala 450 455 460 Cys Thr Ilie Gly Ala Val Ala Gly Ser Leu Leu Ile Ilie Ser Pro Ser 465 470 475 480 Ser Gly Ilie Ala Thr Leu Gin Giu Val Val Ile Ile Val Ala Phe Pro 485 490 495 Phe Phe Leu Vai Gin Phe Vai Met Met Phe Ser Leu Leu Lys Gly Met 500 505 510 Ser Giu Asp Ala Ala Ala Val Arg Arg Val Gin Thr Arg Gin Trp Giu 515 520 Lys Thr Asp Thr Pro Giu Lys Leu C 530 535 Pro Gly Tyr Asp Asp Giu Gly Asn 545 550 His Asp Glu Asp Gly Asn Ile Val 565 Gly Asp Leu Gly Val Val Gly Asp 580 Gin Giu Met Giy Ser Arg Phe Lys 595 600 Ser Arg Asp Giu Tyr Asp Ilie 610 615 (210> 537 <211> 576 <2 12> DNA <213> Corynebacteriun giutamioum <220> <221> CDS <222> (553) <223> RXA00596 <~400> 537 ccgccaocga cggcctcttg aacaccgatg ,iu ?r o Ilie /ali 585 Ilie 525 Ser Pro Vali Pro Thr 605 Pro Leu Ile 575 Giu Pro Al a Glu 560 Giu Ala Gin cataccaaoa ggctgtgctc ggtgaaaatg ccatcggagt gccaagccct agctaccagg gaggaaacta aaa Lys gtg ValI atc Ile toa Ser gaa Giu tto Phe atc Ilie ogc Arg a cq Thr coo Pro atc Ile ac Thr tac T yr tgc Cys cgc Arg cca Pro got Aia cca Pro atc Ile aag Lys tgg T rp gog Ala ott Leu acc Thr ccc Pro ctg Le u gt a Vali cga Arg gog Ala 9go Gly 75 at 0 Ile aaa Lys gtg Val1 act Thr 60 gao Asp ggo Giy aag Lys aoo Thr 45 oot Pro 000 Pro oag Gin gao Asp 30 aog Thr too Ser aoo Thr atg Met i ot 0 Leu tto Phe oag Gin too Ser otg Le u Leu tot Ser aao As n at o Ile ott Le u atc Ile Asn ggo Giy 000 Pro goa Al a Gi y ca a Gin Ala tto Phe gtt Val1 goo Al a ot a be u goa Ala ott aao goo otg Leu ago Ser gt t Vali ot g Le u og 0 Arg gt g Val1 115 163 211 259 307 355 403 ttt ggt Phe Giy too gat ooa gta gaa gtt ttt gaa too ato goo gat atg gaa Ser Asp Pro Val Giu Val Phe Glu Ser Ile Ala Asp Met Giu 95 100 caa cgc ctc gtc cct tcq gtc gct tca att gac cac qgc gtc cca ggc Gin Arg Leu Val pro Ser Val Ala Ser Ile Asp His Giy Val Pro Gly 105 110 115 caa ggc cct tac aag gag atc cgc ccc ago gat gct gag tgg cca agt Gin Gly Pro Tyr Lys Gin Ile Arg Pro Ser Asp Ala Gin Trp Pro Ser 120 125 130 cgc gag atc gct gac acc gcc caa aac acc gtc agc caa gac aag agg Arg Giu Ile Ala Asp Thr Ala Gin Asn Thr Val Ser Gin Asp Lys Arg 135 140 145 gag ttt taaaacaaca tgactgcttt tgg Gin Phe 150 <210> 538 <211> 151 <212> PRT <213> Corynebacterium giutamicun 451 499 547 576 <400> 538 Met Leu Asn Ala Len Lys Phe Ile Pro Ser As n Ile Len Ile Ala Gl y Gin 130 Gin Gly Pro Al a Gly Gin As p Val1 115 Trp Asp Phe Val1 Al a Leu Ala Met 100 Pro Pro Lys Se r Val1 Leu Arg Val1 Gin Ci y Ser Arg Ile Arg Thr 55 Pro Cly Arg Cly Clu 135 Phe Thr T yr 40 Cys Arg Ser Leu Pro 120 Ile Trp Al a Leu Thr Pro Pro Pro Lys Asp Len Ile Cly Gin Ile Phe Val1 Arg Al a Gly Val1 Ser Gin Thr Lys Val1 Thr Asp Gin ValI Ile Al a 140 Lys Thr Pro Pro Val1 Ala Arg 125 Gin Asp Thr Ser Thr Ph e Ser 110 Pro As n Gly Phe Len Leu Se r Asp Asp Val1 <210> 539 <211> 750 <212> DNA <213> Corynebacterium glntamicnm <22 0> <221> CDS <222> (727) <223> RXA02364 <400> 539 gcgaaagtat ctaaggtcgt ttqattggtt tactaccccc catcgagcac caaatgagcg tgatccggga tcaggatctg gaagtggggg ttattggcag atg gag cca ctg ttc 11 Met Giu Pro Leu Phe caa agt ctt qg Gin Ser Leu Ala qaa Giu tcg gac aat att Ser Asp Asn Ile tct Ser 15 gtc att ggt gga Val Ile Gly Gly ttt acc Phe Thr caa ggc acc Gin Gly Thr gct gac ctg Ala Asp Leu aat ctg tac acc Asn Leu Tyr Thr gat gcg ccg gtg Asp Ala Pro Val aaa aga ccc Lys Arg Pro gcc atg cac Ala Met His gct gqa aag aag Ala Gly Lys Lys cgc gtc cag gaa Arg Val Gin Glu t cc Se r atc cqc Ile Arg atg att gaa ctc Met Ile Glu Leu ggt ggc tcg qca Gly Giy Ser Ala ccg ttg act tac Pro Leu Thr Tyr ggc Gi y gag gta tat acc Glu Val Tyr Thr gCg Ala atg cag tct ggt Met Gin Ser Giy ctg gat ggc gcg Leu Asp Gly Ala 307 355 403 aat aac gag atc Asn Asn Giu Ile agt Ser tac gtt acc caa Tyr Val Thr Gin aac Asn 95 cac ttc gag gtt His Phe Glu Val gct cqc Ala Arg 100 tao aac ago aac acc aat cac ott gtc Tyr Asn Ser Asn Thr Asn His Leu Val 105 110 ggt ttg gat tac Gly Leu Asp Tyr atg gtc atg Met Vai Met 115 gaa ttg ttc Giu Leu Phe cga cac gat Arg His Asp 120 ctg ctt gac gc Leu Leu Asp Ala agc gag cca gac Ser Glu Pro Asp ctg gaa Leu Giu 135 gaa tgg gac gcc Giu Trp Asp Ala atg act gag cac Met Thr Giu His a cq Thr 145 gat ctg tgg aac Asp Leu Trp Asn gaa act gat gcc Giu Thr Asp Ala att gaa aag gcg Ile Giu Lys Ala got ggg gga gcg Ala Gly Gly Ala ttc gtt gag gtg Phe Val Giu Val gat Asp 170 gog caa gca ttt Ala Gin Ala Phe gat gca ctg gct Asp Ala Leu Ala ccc atc Pro le 180 aaa gac gaa Lys Asp Giu ttc Phe 185 ttg acc tca gaa Leu Thr Ser Glu cag cqt gaa oto Gin Arg Giu Leu tac gaa gca Tyr Giu Ala 195 gtg cgc gcc got gat act tca gga ggt gcg gca tca Val Arg Ala Ala Asp Thr Ser Gly Gly Ala Ala Ser tgatqaattt NO200 205 S taagtccatc gtg <210> 540 <211> 209 <212> PRT <213> Corynebacterium giutamicum <400> 540 S Met Glu Pro Leu Phe Gin Ser Leu Ala Glu Ser Asp Asn Ile Ser Val 750 1 Ile Pro Glu Thr Leu Phe Asp Asp Thr 145 Ala Ala Glu Ser Gi y Val1 Ser Pro Asp Glu Tyr Arg 130 Asp Gly Leu Leu Gly Lys Ala Leu Gly Val Met 115 Glu Leu Gly Al a Tyr 195 Th r Pro His Tyr Glu Arg Met Phe As n Glu 165 Ile Al a Gin Al a Ile Gi y 70 As n Tyr Arg Leu Th r 150 Phe Lys Val1 Gly Asp Arg 55 Glu As n As n His Glu 135 Glu Val1 Asp Arg Thr Leu 40 Met Val1 Giu Ser Asp 120 Giu Thr Giu Glu Al a 200 Arg Ala Ile Tyr Ile As n 105 Leu T rp Asp Val1 Phe 185 Al a Asn Gly Glu Thr Ser 90 Thr Leu Asp Al a Asp 170 Leu Asp Le u Lys Le u Al a 75 Tyr As n Asp Al a Val1 155 Ala Thr Thr T yr Lys Met Met Val1 His Ala Ala 140 Ile Gin Se r Ser Thr Ile Gly Gin Thr Le u Met 125 Met Glu Ala Glu Gly 205 Thr Arg Giy Ser Gin Val1 110 Ser Thr Lys Phe Phe 190 Gly Asp Val1 Ser Gly As n Gly Glu Giu Ala Thr 175 Gin Ala Al a Gin Ala Val1 His Le u Pro His Lys 160 Asp Arg Ala <210> 541 <211> 888 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101)..(865) <223> RXN01411 <400> 541 cttatcgacg tocccatccc cctcgccaat gcttcggcga tgotagcctt ttcgcaatcg ttcagcccgc cccgacgtoa ggggttctat ttattgtgtg atg ttg gga gtg Met Leu Giy Val 1 tgg cgc att cca Trp Arg Ile Pro otg atg goc gtg Leu Met Ala Val ota ggg ctt atc Leu Giy Leu Ile ggo tgg Gly Trp tgg atc cgc Trp Ile Arg coo gaa got Pro Glu Ala acc Thr ggt gcc cag gaa Gly Ala Gin Glu gta ogo coo gca Val Arg Pro Aia too gaa cgc Ser Glu Arg aag atg atg Lys Met Met 211 259 cot att aag cag Pro Ile Lys Gin gca Ala 45 ttg ogt aot gag Leu Arg Thr Giu tgg Trp ttg ogg Leu Arg gta ggt ggo ttt Val Giy Giy Phe tot tgo aoo ggt Ser Cys Thr Gly ago ttc tao att Ser Phe Tyr Ile aoo aog tao atg Thr Thr Tyr Met aco Thr act tto otg 090 Thr Phe Leu Arg aco gto gga otg Thr Vai Gly Leu 990 aog tta gtg Gly Thr Leu Val otg Leu got gga aao ato Aia Giy Asi Ile ato Ile 95 got oto ago atg Ala Leu Ser Met goa. goa Ala Ala 100 att gtg 900 Ile Val Ala aac ato atg Asn Ilie Met 120 coa Pro 105 ttt gtt 990 ogo Phe Val Gly Arg att gat aaa tto Ile Asp Lys Phe 000 090 099 Pro Arg Arg 115 909 atc 009 Ala Ile Pro 451 499 gct tto got aco Ala Phe Ala Thr ago aoa gta att Ser Thr Val Ile gcc tao Ala Tyr 135 ato att goa ggt Ilie Ile Ala Gly oaa Gln 140 ggt act ttg act Gly Thr Leu Thr tot ttg att 909 Ser Leu Ile Ala cag Gin 150 gta atg ott gga Val Met Leu Gly atc Ilie 155 990 909 gtt aco Gly Ala Val Thr got Al a 160 aao tgo gtt aoo Asn Cys Val Thr 547 595 643 gta atg atg gc Val Met Met Ala gto ttc caa gag Val Phe Gin Glu gtc Val1 175 aco 090 ggt aot Thr Arg Gly Thr too gc Ser Ala 180 990c att aco Gly Ilie Thr ttt ato too Phe Ilie Ser 200 aao gto act tao Asn Val Thr Tyr ato ttc 990 990 Ile Phe Giy Gly tog got oca Ser Ala Pro 195 Otg 900 Oct Leu Ala Pro aoo goa ttg gto Thr Ala Leu Val too Ser 205 tgg aco ggo ago Trp Thr Gly Ser gcg gta tac atg atc atc att gcg ctc ttc gcc ttc acc gcg tcc cgc 787 Ala Val Tyr Met Ile Ile Ile Ala Leu Phe Ala Phe Thr Ala Ser Arg 215 220 22$ ttc att cct qaa acc tcc cca gtt ttt qtc acc qca acc ccq gcc att 835 Phe Ile Pro Glu Thr Ser Pro Val Phe Val Thr Ala Thr Pro Ala Ile 230 235 240 245 aag gca cca aag gtg ctg gtc aac ccg ggt taaaccacgc ttttcgacga 885 Lys Ala Pro Lys Val Leu Val Asn Pro Gly 250 255 aaa 888 <210> 542 <211> 255 <212> PRT <213> Corynebacterium glutamicum <400> 542 Met Leu Gly Val Gly Trp Arg Ile Pro Phe Leu Met Ala Val Pro Leu 1 5 10 Gly Leu Ilie Gly Trp Trp Ile Arg Thr Gly Ala Gin Giu Asn Val Arg 25 Pro Ala Ser Clu Arg Pro Glu Ala Pro Ile Lys Gin Ala Leu Arg Thr 40 Giu Trp Lys Met Met Leu Arg Val Gly Gly Phe Ile Ser Cys Thr Gly 55 Leu Ser Phe Tyr Ile Phe Thr Thr Tyr Met Thr Thr Phe Leu Arg Ser 70 75 Thr Val Gly Leu Glu Gly Thr Leu Val Leu Ala Gly Asn Ile Ile Ala 90 Leu Ser Met Ala Ala ile Val Ala Pro Phe Val Gly Arg Ala Ile Asp 100 105 110 Lys Phe Pro Arg Arq Asn Ile Met Ala Phe Ala Thr Leu Ser Thr Val 115 120 125 Ile Met Ala Ile Pro.Ala Tyr Ile Ile Ala Giy Gin Gly Thr Leu Thr 130 135 140 Ala Ser Leu Ile Ala Gin Val Met Leu Giy Ile Gly Ala Val Thr Ala 145 150 155 160 Asn Cys Val Thr Ser Vai Met Met Ala Glu Val Phe Gln Glu Val Thr 165 170 175 Arg Giy Thr Ser Ala Gly Ile Thr Tyr Asn Val Thr Tyr Ala Ile Phe 180 185 190 Gly Giy Ser Ala Pro Phe Ile Ser Thr Ala Leu Val Ser Trp Thr Gly 195 200 205 Ser Pro Leu Ala Pro Ala Val Tyr Met Ilie Ile Ile 210 215 220 Ala Leu Phe Ala Phe Thr Ala Ser Arg Phe Ile Pro Glu Thr Ser 225 230 235 Ala Thr Pro Ala Ile Lys Ala Pro Lys Val Leu 245 250 Pro Val Phe Val Val Asn Pro <210> 543 <211> 1058 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1035) (223> RXN00960 <400> 543 atg gct cgg cat tgt Met Ala Arg His Cys 1 5 tgc agc aat cgc Cys Ser Asn Arg gcg tcc acc gtc Ala Ser Thr Val ttc tcc Phe Ser ggt ctg ato Gly Leu Ile aaa gac cac Lys Asp His gcc Ala tac gqa gca tcc Tyr Gly Ala Ser gcg ctc tac cca Ala Leu Tyr Pro tgg ctg ctg Trp Leu Leu ggt 9CC ctc Gly Ala Leu caa agc gtc aco Gin Ser Val Thr atc gac ctt gat Ile Asp Leu Asp gca Ala cag ccc Gin Pro tac ttc aac atc Tyr Phe Asn Ilie atg cca cca cca Met Pro Pro Pro ttt Phe gaa gtg atq acc Glu Val Met Thr gca Ala ctg ctg ctg gca Leu Leu Leu Ala ttc Phe 70 tgC ctc ggc ctg Cys Leu Gly Leu atq gct gta att Met Ala Val Ile aaa Lys tca gac acc ctg Ser Asp Thr Leu ttc Phe aag gta acc cgc Lys Val Thr Arg ctc gag cgc gta Leu Glu Arg Vai gtc atg Val Met aag acc atc Lys Thr Ilie ggc atc ttc Gly Ilie Phe 115 gcc ttt gtc atc Ala Phe Val Ilie ctg ctg cca ctc Leu Leu Pro Leu ttc atc ttc ?he Ile Phe 110 gag atc atg Glu Ile Met ctc ggc atg ggc Leu Gly Met Gly aac ggt ggc ctc Asn Gly Gly Leu tcc 9CC Ser Ala 130 ttt ggc aag gta Phe Gly Lys Val ctg Le u 135 att ctc gcc gtc Ile Leu Ala Val gga acc ctg ctc Gly Thr Leu Leu cta gcc atc cag Leu Ala Ilie Gin ttc Phe 150 att atc gct ggt Ile Ilie Ala Gly gca Al a 155 gta tcc aag aag Val Ser Lys Lys cca tgg aaa ctg Pro Trp Lys Leu aaa aac atg ctc Lys Asn Met Leu cct Pro 170 gca tac ttc act Ala Tyr Phe Thr gca ctq Ala Len 175 ggc act tc Gly Thr Ser ctg aaa aac Leu Lys Asn 195 tct Ser 180 tca gcg gca acc Ser Ala Ala Thr cca gtg acc tac: Pro Val Thr Tyr cag cag acc Gin Gin Thr 190 gtc cca ctg Val Pro Leu gat gtt gat gtc Asp Val Asp Val aac As n 200 gtc gca ggc ttt Val Ala Gly Phe qt t Val1 205 tgc gcc Cys Ala 210 acc atc cac cta Thr Ile His Leu gga tcg atg atg Gly Ser Met Met atc ggc ctc ttc Ile Gly Len Phe acc Thr 225 ttC gct gtt gtc Phe Ala Val Val atq tac qac atq Met Tyr Asp Met gta qqc gtc ggc Val Giy Val Gly ctc Len 240 tcc atc: qga ttc Ser Ile Gly Phe ct C Leu 245 ctc atg ctg ggc Len Met Leu Gly atc Ile 250 acc atg atc gcc Thr Met Ile Ala qca cca Ala Pro 255 ggC gtt ccc Gly Vai Pro atg ctc gqa Met Leu Gly 275 ggc Gi y 260 gga gcc atc atg Gly Ala Ile Met gca acc qqc atg Ala Thr Gly Met ctg gcc tcc Leu Ala Ser 270 gcc gct tac Ala Ala Tyr ttc aac acc gaa Phe Asn Thr Glu caa Gin 280 gtc: gcc ctc atg Val Ala Leu Met atc gcg Ile Ala 290 att gac tcc ttC Ile Asp Ser Phe 9gC Gly 295 acc gca gca aac Thr Ala Ala Asn gtC Val1 300 acc ggc gac ggc Thr Gly Asp Giy atc: gca gtc atc Ile Ala Val Ile aac aaa ttc gcc Asn Lys Phe Ala ggc cag ctq cac Gly Gin Len His 912 960 1008 act tcc cca gat Thr Ser Pro Asp atc gaa gaa gac Ile Gin Gin Asp cgc gtt gcc ttC Arg Val Ala Phe gac atc Asp Ile 335 act cca tcg Thr Pro Ser gtg gaa. cat cac Val Gin His His aag Lys 345 tagaaacccg cattttctgt 1055 1058 <210> 544 <211> 345 <212> PRT <213> Corynebacterinm gintamicnm <400> 544 Met Ala Arg His Cys Cys Ser Asn Arg Tyr Ala Ser Thr Val Phe Ser Gly Len Ile Ala Tyr Gly Ala Ser Gin Ala Len Tyr Pro Trp Len Len Lys Gin Ala Ser Ly's Gly Ser Phe 145 Pro Gly be u Cx's Thr 225 Ser Gly Met Ile Al a 305 Thr Thr His T yr Leu Thr Ile Phe 115 Phe Ala Lys Ser As n 195 Th r Al a Gly Pro Gix' 275 Ile Ala Pro Ser Gin Phe Le u Le u Th r 100 Leu Gly Ile Leu Ser 180 Asp Ile Val1 Phe Gi x 260 Phe Asp Val1 Asp Asp 340 Ser Asn Ala Phe Ala Gly Lys Gin Phe 165 Se r ValI His Val1 Le u 245 Gly As n Se r Ile Gi u 325 Val1 Val1 Ile Phe 70 Lys Phe Met Val1 Phe 150 Ly's Al a Asp Leu Phe 230 Le u Al a Thr Phe Val1 310 Ile Giu Thr Giu 40 Glu Met Cx's Leu Val Thr Val Ile Gix' Met 120 Leu Ile 135 Ile Ile Asn Met Ala Thr Val Asn 200 Ala Glx' 215 Met Tyr Met Leu Ile Met Giu Gin 280 Gix' Thr 295 Asn Lx's Giu Giu His His 25 Ile Pro Gly Arg Pro 105 As n Leu Al a Leu Ile 185 Val1 Se r Asp Gly Ala 265 Val1 Ala Phe Asp Ly's 34S Asp Pro Leu Giu 90 Leu Gix' Ala Gix' Pro 170 Pro Ala Met Met Ile 250 Ala Al a Al a Al a Asp 330 be u Pro Glx' 75 Le u Leu Gi x Val1 Al a 155 Ala Vali Gix' Met Giu 235 Thr Thr Leu Asn Ly's 315 Arg Asp Phe Met Giu Pro Leu ValI 140 Val1 Tyr Thr Phe Ly's 220 ValI Met Cix' Met Val 300 Gix' ValI Ala Glu Ala Arg Le u Le u 125 Gix' Ser The Tyxr Val1 205 Ile Gix' Ile Met Ile 285 Thr Gin Ala Cix' Ala Val Met Vai Ile Val Val Phe Ile 110 Giu Ile Thr Leu Lx's Lx's Thr Ala 175 Gin Gin 190 Val Pro Gix' Leu Vai Gix' Ala Ala 255 Leu Ala 270 Ala Aia Glx' Asp Leu His Phe Asp 335 be u Thr Lys Met Phe Met be u As n 160 be u Thr Leu Phe be u 240 Pro Ser Tyr Gix' Thr 320 Ile <210> 545 <212> DNA <213> Corynebacterium glutamicum <220> K1 <221> CDS <222> (1)..(1095) <223> RXN02447 <400> 545 aca Thr 1 99C Gly ott Leu att Ile gt 0 Val1 ctg Leu gtc Val gtg Val1 ggc Gly ggc Gly 145 ato Ile gta gtt Val Val toc ctg Ser Leu gcc ttc Ala Phe gat gga Asp Cly goc oto Ala Leu gto aac Val Asn ogt acc Arg Thr cac tot His Ser 115 cag got Gin Ala 130 gaa gto Giu Val ggt gtt Gly Val ocg Pro aco Thr gtg Val1 ato Ile tto Ph e oa g Gin ct Pro 100 ga a Giu tca Ser ot 0 Le u goa Al a gtg Val 5 ggo Gi y atc Ile tg Trp otc Leu ggg Gly gag Giu aao Asn ggo Gly a go Ser gtt Val1 165 tao oto got Tyr Leu Ala og a Arg aao As n cgo Arg 9gC Gly 70 cgt Arg ogt Arg aat As n cag Gin aao As n 150 goo Al a aao Asn gog Al a ato Ile 55 atg Met tao Tyr gog Ala gog Ala gtt Val1 135 aaa Lys cag Gin gag Glu ott Leu 40 at g Met ctg Le u gac Asp aaa Lys goa Ala 120 tot Se r t gg T rp oag Gin ga a Giu ott Le u 25 ato Ile tto Phe ogg Arg gao Asp gc Al a 105 ott Leu ago Ser ot g Le u oto Le u oto goa ooa ota Leu Ala Pro Leu gaa ato ogo Glu Ile Arg 10 got ato Ala Ile goo gto Ala Val goc gto Ala Val atq cog Met Pro 75 goc ogo Ala Arg 90 gaa atg Giu Met Oct ggt Pro Gly aag oao Lys His gtt cgt Vai Arg 155 aco ggo Thr Gly 170 gto Val aco Thr tgt Cys gaa Giu ogo Arg gat Asp gtt Val1 acc Thr 140 otg Leu ato Ile aco ggo Thr Gly ota cac Leu His goo oto Ala Leu tca oca Ser Pro gto atg Val Met gaa ato Giu Ile 110 aag cag Lys Gin 125 oao atg His Met oto ato Leu Ile aao goo Asn Ala cag otg Gin Leu gga gtt Gly Val cot gco Pro Ala ogo tgg Arg Trp gag aoo Giu Thr ato gog Ile Ala tot tog Ser Ser too ato Ser Ilie goo ggc Ala Gly 160 ato atg Ile Met 175 48 96 144 192 240 288 336 384 432 480 528 576 tao tao gga aoo ogo gto oto gag gaa too ggo atg ago gca gaa atg Tyr Tyr Gly Thr Arg Val Leu Glu Giu Ser Gly Met Ser Ala Giu Met gct gtg gtt Ala Val Val 195 goc aac att gct Ala Asn Ile Ala ggt gcc gtt Gly Ala Val gcc gtc atc gqt qga Ala Val Ile Gly Gly 205 ctg atc Leu Ile 210 gca ctg cgc aac Ala Leu Arg Asn atg Met 215 gac cgc ctg gat Asp Arg Leu Asp cgC Arg 220 cgc acc acc ttc Arg Thr Thr Phe atc ggc ctg tca Ile Gly Leu Ser ctg Leu 230 acc acc acc ttc Thr Thr Thr Phe cac His 235 ctt ttg atc gca Leu Leu Ile Ala gct Ala 240 goc ggc act ctc Ala Gly Thr Leu cca gaa ggt aac: Pro Giu Gly Asn att cga cca ttc: Ile Arg Pro Phe gcc atc Ala Ile 255 atg atc ctt Met Ile Leu gtt gca gtg Val Ala Val 275 gtt ggg ttc gtg Val Gly Phe Val ctc: Le u 265 tcc atg cag act Ser Met Gin Thr ttc ctc aac Phe Leu Asn 270 cga atg aaq Arg Met Lys 816 864 tgg gtg tgg ctg Trp Vai Trp Leu gaa atc ttc cca Giu Ile Phe Pro ggt atc Gly Ile 290 ggc acc ggt att Gly Thr Gly Ile gta ttc tgc ggt Val Phe Cys Gly ggc atc aat ggc Giy Ile Asn Gly ota gcg ttg ttc Leu Ala Leu Phe cca gca ctg gtc Pro Ala Leu Val tcC Se r 315 ggc gtg ggt atc Gly Vai Gly Ile 912 960 1008 ttc tcc ttc ctt Phe Ser Phe Leu ttc qca gtc gtc Phe Ala Val Val gga, Gi y 330 gtc att gCC Ctg Val Ile Ala Leu gcg ttC Ala Phe 335 gtc acc aaq Val Thr Lys gat cac gca Asp His Ala 355 ttt Phe 340 gtt cct qaa acc Val Pro Giu Thr ggc cgc tca ctt Gly Arg Ser Leu gaa gaa ctc Giu Glu Leu 350 taaaccccct 1056 1105 gca ttc acc gyc Ala Phe Thr Gly etc ttc aag aag Ile Phe Lys Lys ccgatctctt tgg 1118 <210> 546 (211> 365 (212> PRT <213> Gorynebacterium giutamicum (400> 546 Thr Val Val Pro Val Tyr Leu Ala Giu Leu 1 5 10 Ala Pro Leu Glu Ile Arg Gly Ser Leu Thr Gly Ary Asn Giu Leu 25 Leu Ala Phe Vai Ile Asn Ala Leu Ile 40 Ala Ile Val Thr Gly Gin Leu His Gly Val Ala Val Thr Le u Ile Val1 Leu Val1 Val Gly Gly 145 Ile T yr Ala Le u Ile 225 Ala Met Val1 Gly Val 305 Phe Val1 Asp Asp Al a Val1 Arg His Gin 130 Glu Gly T yr Val1 Ile 210 Ile Gi y Ile Ala Ile 290 Leu Ser Thr His Gly Leu As n Thr Ser 115 Ala Val1 Val1 Gi y Val1 195 Ala Gi y Thr Le u Val1 275 Gi y Ala Phe Lys Ala 355 Ile Phe Gin Pro 100 Glu Ser Leui Al a Thr 180 Ala Leu Leu Leu ValI 260 Trp Thr Le u Leu Phe 340 Ala Trp Leu Gly Glu Asn Gly Ser Val 165 Arg Asn Arg Ser Leu 245 Val1 Vai Gly Phe Ile 325 Val1 Phe Arg Gly 70 Arg Arg As n Gin As n 150 Ala Val1 Ile As n Leu 230 Pro Gly Trp Ile Phe 310 Phe Pro Th r Ile 55 Met Tyr Ala Ala Val1 135 Lys Gln Le u Ala Met 215 Thr Glu Phe Leu Ser 295 Pro Al a Glu Gly Met Leu Asp Lys Al a 120 Ser T rp Gln Glu Phe 200 Asp Thr Gly Val1 Ala 280 Val1 Al a ValI Thr Gln 360 Phe Arg Asp Ala 105 Leu Se r Leu Leu Glu 185 Gly Arg Thr As n Leu 265 Glu Phe Leu Val1 Arg 345 Ile Ala Val Met Pro 75 Ala Arg 90 Giu Met Pro Gly Lys His Val Arg 155 Thr Giy 170 Ser Gly Ala Val Leu Asp Phe His 235 Ser Ile 250 Ser Met Ile Phe Cys Gly Val Ser 315 Gly Val 330 Gly Arg Phe Lys Cys Glu Arg Asp Val1 Thr 140 Leu Ile Met Al a Ar g 220 Leu Arq Gln Pro Trp 300 Gly Ile Ser Lys Al a Se r Val1 Glu Lys 125 His Leu As n Ser Val 205 Arg Leu Pro Th r Val 285 Gly Val1 Al a Leu Al a 365 Leu Pro Met Ile 110 Gln Met Ile Ala Al a 190 I le Thr Ile Phe Phe 270 Arg Ile Gly Leu Glu 350 Pro Arg Glu Ile Ser Ser Ala Ile 175 Glu Gly T hr Ala Ala 255 Leu Met Asn Ile Ala 335 Glu Al a Trp Thr Al a Ser Ile Gl y 160 Met Met Gi y Ph e Al a 240 .le As n Lys Gl y Th r 320 Phe Leu <210> <211> <212> <2 13> <220> <221> <222> <223> 547 2013 DNA Corynebacterium glutamicum C DS (101) (1990) RXN 02395 <400> 547 aaacaggaat atttaacteg aettettaaa aaagctetat cagcaccacc tcattgtggt gcacaatgga gaggacacac acgtaaatat cttgcccatc atg tee ace aac Met Ser Thr Asn 1 ggc aat aac ttg Gly Asn Asn Leu gaa. tec caa gag Glu Ser Gin Glu ccc gag gaa ect Pro Glu Giu Pro eat tat His Tyr cct eac gac Pro His Asp caa cge aac Gin Arg Asn ace Thr cac cca ggc cta His Pro Gly Leu cct ggc att tcg Pro Gly Ile Ser gtc gat gct Val Asp Ala gtc acc gca Val Thr Ala aag tte gga etc Lys Phe Gly Leu ga c Asp 45 aaa acc gtt ttc Lys Thr Val Phe ggc Gi y gca tta Ala Leu att etg gcg tte Ile Leu Ala Phe gce tgg ggc att Ala Trp Gly Ile agc ect gat tcg Ser Pro Asp Ser gtt Val tct tca gta teg Ser Ser Val Ser tc Ser 75 acg atg tte agt Thr Met Phe Ser tgg Trp get atg aeg aat Ala Met Thr Asn ggt tgg etc ctc Gly Trp Leu Leu ttt gtc atg etg Phe Val Met Leu ate Ile gge att ggc ac Gly Ile Gly Thr atg cte Met Leu 100 307 355 403 451 499 tac ate get Tyr Ile Ala gac gaa eca Asp Glu Pro 120 teg ege tae gge Ser Arg Tyr Gly ate aaq etg gge Ile Lys Leu Gly aeg gac gaa Thr Asp Giu 115 aty ttc gge Met Phe Gly gaa ttc tct eqe Glu Phe Ser Arg tee tgg att geg Ser Trp Ilie Ala atg Met 130 gee gge Ala Gly 135 ate ggt gte ggt Ile Gly Val Gly ate Ile 140 tte tte tte ggt Phe Phe Phe Gly cet Pro 145 tee gaa eeg etg Ser Glu Pro Leu eat tat ete agt His Tyr Leu Ser eee Pro 155 eea eet eae ace Pro Pro His Thr gaa gga tet aea Giu Gly Ser Thr cct Pro 165 547 595 643 gag tee ttg cae Giu Ser Leu His caa Gin 170 gca ctt geg cag Ala Leu Ala Gin eac tte eac tg His Phe His Trp ggc tta Gly Leu 180 tcc gcc tgg Ser Ala Trp agt tac cga Ser Tyr Arg 200 ggg Gly 185 otg tat gcc ttg Leu Tyr Ala Leu gt c Val1 190 ggc ggc gog ttg Giy Gly Ala Len gog ~tac tcc Ala Tyr Ser 195 ttc cgg tca Phe Arg Ser cgc ggc cgc gta Arg Gly Arg Val ttg atc agc tcc Len Ile Ser Ser acc Thr 210 ctt ttc Len Phe 215 ggt gag aaa aco Gly Gin Lys Thr gaa Glu 220 ggt atc gcg ggt Giy Ile- Ala Gly ogo Arg 225 cto atc gao atg Leu Ile Asp Met gog ato atc gc Ala Ile Ile Ala otg ttt gga aog Leu Phe Gly Thr gca acc ttg qgc Ala Thr Len Gly 787 835 883 tca gca att cag Ser Ala Ile Gin gt t Val1 250 ggt cag ggc gtg Gly Gin Gly Val cag Gin 255 att att tct ggc Ile Ile Ser Gly got tog Ala Ser 260 gaa atc acc Gin Ile Thr ggo ttc atc Gly Phe Ile 280 aac As n 265 aac ato ttg ato Asn Ile Len Ile gc Ala 270 atc atc gog ato Ile Ile Ala Ile ttg aco att Len Thr Ile 275 att cgt tat Ile Arg Tyr atc too tca gta Ile Ser Ser Val tot Ser 285 ggo gtg too aag Gly Vai Ser Lys ott too Len Ser 295 aac oto aat att Asn Len Asn Ile ttg aog ott gga Len Thr Leu Gly t tg Len 305 gto otg ttt gtg Val Len Phe Val tto Phe 310 ato aoc ggo 000 Ile Thr Gly Pro aco Thr 315 ttg tto otg oto Len Phe Len Len aao As n 320 ttg ato ooa tog Len Ile Pro Ser gtg ttg gaa tat Vai Len Gin Tyr agt gag ttc ttg Ser Gin Phe Leu toa Se r 335 atg got ggo aag Met Ala Gly Lys tot ttg Ser Leu 340 1027 1075 1123 1171 1219 tog tgg ggt Ser Trp Gly tao tgg goa Tyr Trp Ala 360 gaa aoo att gaa Gin Thr Ile Gin caa gct ggt tgg Gin Ala Gly Trp aog gog tto Thr Aia Phe 355 atg tto atc Met Phe Ile tgg tgg ato goa. Trp Trp Ile Ala act ooa tto gtg Thr Pro Phe Val gcg cgt Ala Arg 375 att tot cgo ggc Ile Ser Arg Gly cgc Arg 380 aco ttg ogt gaa ttc gog oto ato aoo Thr Len Arg Giu Phe Ala Leu Ile Thr Q 385 1267 a tg Met 390 got ato ooo too Ala Ile Pro Ser att ttg ato otg Ile Len Ile Len gog Aila 400 ttc aoo att tto Phe Thr Ile Phe ggt Gi y 405 1315 1363 gga act goo atc aog Gly Thr Ala Ile Thr 410 atg aao ogo gag Met Asn Arg Giu gta gat ggt ttt Val Asp Gly Phe gao ggo Asp Gly 420 agt tca tcc Ser Ser Ser etg tac teg Leu Tyr Ser 440 aag Lys 425 gaa eag gtg ctg Giu Gin Val Leu ttt Phe 430 gat atg ttc agc Asp Met Phe Ser aac ctt ccg Asn Leu Pro 435 gca gta ttc Ala Val Phe atc aca ccg ttc Ile Thr Pro Phe ttq ate ttt gtg Leu Ile Phe Val ttt gtt Phe Vai 455 aec tct gcc gat Thr Ser Ala Asp tee Ser 460 gcc tce gtg gtg Ala Ser Val Val gga acg atg agc Gly Thr Met Ser 1411 1459 1507 1555 1603 tcc Se r 470 caa ggt aac cct Gin Giy Asn Pro cca aac aaa tta Pro Asn Lys Leu ate: Ilie 480 gtg gtg ttc tgg Vai Val Phe Trp etg tge atg atg Leu Cys Met Met atc geg gtg gte Ilie Ala Val Val ctq ctt act ggt Leu Leu Thr Giy ggc gaa Giy Glu 500 tcc gcg ctg Ser Ala Leu ttt geg ctg Phe Ala Leu 520 act Thr 505 ggt ctg cag aac Giy Leu Gin Asn etc Le u 510 ace att ttg ate Thr Ile Leu Ile gee att ccg Ala Ile Pro 515 aaq gac tta Lys Asp Leu 1651 1699 gtg ttg ate gtq Val Leu Ilie Val get att gee ttt Ala Ile Ala Phe tee aca Ser Thr 535 gac eca gee get Asp Pro Ala Ala ega eaa cge tat Arg Gin Arg Tyr aag gea gee ate Lys Ala Ala Ile tet Ser 550 aae geg gtg gtt Asn Ala Val Val eg t Arg 555 ggc ttq gaa gaa Gly Leu Glu Giu eae His 560 gge gac gae ttc Gly Asp Asp Phe gag Glu 565 1747 1795 1843 ete tee ate gaa Leu Ser Ile Glu eet Pro 570 gea gag gaa ggt Ala Giu Giu Gly cqt Arg 575 gga geg ggt get Gly Ala Gly Ala ace tte Thr Phe 580 gat tee ace Asp Ser Thr gaa gge aat Giu Gly Asn 600 get gat eae ate ace gac tgg tat eag ege aee gae gaa Ala Asp His Ile Thr Asp Trp Tyr Gin Arg Thr Asp Glu 585 590 595 1891 gat gtt gat tat Asp Val Asp Tyr tte ace ace gqe Phe Thr Thr Gly tgg gee gat Trp Ala Asp 1939 ggt tgg Gly Trp 615 aca eeg gaa teg Thr Pro Glu Ser gaa gaa gge gaa Giu Glu Gly Giu gac geg aaa aag Asp Ala Lys Lys 1987 taaaaaataa cgaetggetg gga 2013 <210> 548 <211> 630 <212> PRT <213> Corynebacteriun giutamieum <400> 548 Met Ser Thr Asn Ser Gly Asn Asn Leu Pro Glu Ser Gin Glu Ser Pro 1 5 10 Glu Ile Phe Ser Ala Ile Leu Ala Pro 145 Glu Phe Ala Ser Arg 225 Ala Ile Ala Lys Leu 305 Glu Ser Gly Ser Met Gly Gly Met 130 Ser Gly His Leu Thr 210 Leu Thr Ser Ile Gly 290 Val Pro Val Val Pro Thr Thr Thr 115 Met Glu Ser Trp Ala 195 Phe Ile Leu Gly Leu 275 Ile Leu His Asp Thr Asp Asn Met 100 Asp Phe Pro Thr Gly 180 Tyr Arg Asp Gly Ala 260 Thr Arg Phe Tyr Ala Ala Ser Thr Leu Glu Gly Leu Pro 165 Leu Ser Ser Met Leu 245 Ser Ile Tyr Val Pro Gin Ala Val 70 Gly Tyr Asp Ala Trp 150 Glu Ser Ser Leu Met 230 Ser Glu Gly Leu Phe 310 His Arg Leu 55 Ser Trp Ile Glu Gly 135 His Ser Ala Tyr Phe 215 Ala Ala Ile Phe Ser 295 Ile Asp Asn 40 Ile Ser Leu Ala Pro 120 Ile Tyr Leu Trp Arg 200 Gly Ile Ile Thr Ile 280 Asn Thr Thr 25 Lys Leu Val Leu Phe 105 Glu Gly Leu His Gly 185 Arg Glu Ile Gin Asn 265 Ile Leu Gly His Phe Ala Ser Asn 90 Ser Phe Val Ser Gin 170 Leu Gly Lys Ala Val 250 Asn Ser Asn Pro Pro Gly Phe Ser 75 Phe Arg Ser Gly Pro 155 Ala Tyr Arg Thr Thr 235 Gly Ile Ser Ile Thr 315 Gly Leu Ile Thr Val Tyr Arg Ile 140 Pro Leu Ala Val Glu 220 Leu Gin Leu Val Ser 300 Leu Leu Asp Ala Met Met Gly Phe 125 Phe Pro Ala Leu Thr 205 Gly Phe Gly Ile Ser 285 Leu Phe Val Lys Trp Phe Leu Arg 110 Ser Phe His Gin Val 190 Leu Ile Gly Val Ala 270 Gly Thr Leu Pro Thr Gly Ser Ile Ile Trp Phe Thr Ser 175 Gly Ile Ala Thr Gin 255 Ile Val Leu SLeu Gly Val Ile Trp Gly Lys Ile Gly Val 160 His Gly Ser Gly Ala 240 Ile Ile Ser Gly Asn 320 Leu Ala Gly Val1 Phe 385 Phe Asp Phe Val Met 4 65 Val Leu Leu Phe Ala 545 Gly Ala Gin Gly Val 625 Ile Gly Trp Gly 370 Ala Thr Gly Ser Leu 450 Gly Val1 Thr Ile Ile 530 Lys Asp Gly Arq Lys 610 Asp Pro Lys Thr 355 Met Leu Ile Phe As n 435 Al a Thr Phe Gly Al a 515 Lys Al a Asp Al a Th r 595 Trp Al a Ser Ser 340 Ala Phe Ile Phe Asp 420 Leu Val1 Met T rp Gly 500 Ile Asp Ala Phe Thr 580 Asp Ala Lys Ser 325 Leu Phe Ile Thr Gly 405 Gly Pro Phe Ser Gly 485 Glu Pro Le u Ile Giu 565 Ph e Giu Asp Lys Val Leu Ser Trp Tyr Trp Ala Arg 375 Met Ala 390 Giy Thr Ser Ser Leu Tyr Phe Val 455 Ser Gin 470 Leu Cys Ser Ala Phe Ala Ser Thr 535 Ser Asn 550 Leu Ser Asp Ser Glu Gly Gly Trp 615 Asp 630 Giu Gly Al a 360 Ile Ile Al a Ser Ser 440 Thr Gi y Met Le u Le u 520 Asp Al a Ile Thr As n 600 Thr Tyr Giu 345 Trp Ser Pro Ile Lys '42 5 Ile Ser Asn Met Thr 505 Val1 Pro Val Giu Ala 585 Asp Pro Gly 330 Giu Trp Arq Ser Thr 410 Glu Thr Ala Pro Gly 490 Gly Leu Al a Val Pro 570 Asp Val1 Giu Ser Thr Ile Giy Phe 395 Met Gin Pro Asp Ala 475 Ile Leu Ile Al a Arg 555 Al a His Asp Ser Giu Phe Ile Glu Ala Trp 365 Arg Thr 380 Ile Leu Asn Arg Val Leu Phe Ile 445 Ser Ala 460 Pro Asn Ala Vai Gin Asn Val Met 525 Ile Arq 540 Gly Leu Giu Giu Ile Thr Tyr Asp 605 Thr Glu 620 Leu Ser 335 Phe Gin 350 Thr Pro Leu Arg Ile Leu Glu Asn 415 Phe Asp 430 Leu Ile Ser Val Lys Leu Val Met 495 Leu Thr 510 Ala Ile Gin Arg Glu Giu Gly Arg 575 Asp Trp 590 Phe Thr Giu Gly Met Aia Phe Giu Al a 400 Val1 Met Phe Val1 Ile 480 Leu Ile Al a Tyr His 560 Gly Tyr Thr Glu <210> 549 <211> 2007 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (1984) (223> RXN02348 <400> 549 aaagacccga gccgaagccc tggcctgcgc atacttcctt gtcaacgctc gctgggatta ggtcttttct gagcgctagc atttctccac tcaaaggagc atg ctt aac cgc atg aaa Lys ctc Leu ccc Pro gaa Giu acc Thr gct Al a aaa Lys ggc Gly gtt Val1 cgc Arg 150 agt Ser act Thr ctg Leu gt c Val atc Ile gac Asp aac As n 900 Al a ct C Len 135 ttc Phe gcg Al a ctc Leu tac Tyr act Thr act Thr aac Asn c gt Arg g ca Al a 120 agc Ser att Ile Cgg Arg 99 t Gly t ca Ser cag Gin ttg Len caa Gln ggg Gly 105 t tg Leu gca Ala ctg Leu cca Pro 9CC Ala ct t Leu gaa. Glu atc Ile ga Gly cac His ttt Phe aca Thr CCC Pro aaa Lys cta Len cac His aat Asn gt c Val1 75 caa Gin tgg Trp tat Tyr gaa Glu gta Val1 155 tca Se r gg t Gly act Thr gt g Val 60 acc Thr ggt Gly gga Gly ggc Gi y Gly 140 tot Ser gtc gct oca Val Ala Pro 15 gtt ytg ttC Val Val Phe 30 gca tto agc Ala Phe Ser 45 tao ggo atc Tyr Gly Ile gtc aaa tao Val Lys Tyr ggo ato otg Gly Ile Len 95 aaa. ttc gtg Lys Phe Val 110 gat gtg gtg Asp Val Val 125 ttg acg gtt Len Thr Val ctc gca gtt Len Ala Val aaa gtc gqc Lys Val Gly 175 aaa Lys ggC Gly atg Met ato Ile gto Vali 80 gog Ala gca. Ala atc Ile atc Ile ctg Len 160 aaa. Lys Met 1 t cc Ser ga C Asp ca g Gin t cc Ser atg Met ctc Len gta Val1 acc Thr tcc Ser 145 atc Ile gCC Ala Leu Asn gga caa Gly Gin atc ggc Ile Gly cac aac His Asn atg gtg Met Vai ctg gto Leu Val gtt got Val Ala gc ggc Ala Gly 115 cog gcg Pro Ala 130 oca agc Pro Ser got att Ala Ile ttC gg Phe Gly Arg Met got tta Ala Len acc ago Thr Ser aaa gtc Lys Val ttg tgg Leu Trp aoo oga Thr Arg ttg ctg Len Len 100 atg ttg Met Len ato tot Ile Ser ttt gag Phe Gin ttt goa Phe Ala 165 ccc atc Pro Ile 180 115 163 211 259 307 355 403 451 499 547 595 643 atc oaa. cog oto Ile Gin Pro Len ggt aoa gaa Gly Thr Giu 170 atg ttg ctg Met Leu Leu atC qqg cac Ile Giy His 200 ttt gtc acc ctt Phe Val Thr Leu gca Al a 190 gga ttq gga att Gly Leu Giy Ile ccg caa atc Pro Gin Ile 195 tgg gcc ctg Trp Ala Leu 691 739 cca gaa atc ttg Pro Giu Ile Leu aqc ttq tct cca Ser Leu Ser Pro cgc ttg Arg Leu 215 att gtg gct gag Ile Val Ala Glu ttc caa gca ttt Phe Gin.Ala Phe ctg ctt ggt gcC Leu Leu Gly Ala gtt Val1 230 gtc ctg aca gta Val Leu Thr Val acg Thr 235 ggt gcg gaa gcg Gly Ala Giu Ala ct C Leu 240 tac gct gat atg Tyr Ala Asp Met 787 835 883 cat ttt ggg gcg His Phe Giy Ala cca atc aga gtg Pro Ile Arg Val tgg ttt tgc gtc Trp Phe Cys Val gtc atg Val Met 260 cct gct tta Pro Ala Leu cag cct gaa Gin Pro Giu 280 ttq acg tat ttq Leu Thr Tyr Leu gg Gi y 270 cag ggc qcc ttq Gin Gly Ala Leu qtq atc aac Val Ile Asn 275 ccg gaa ggt Pro Giu Gly gcg gtg cgc aac Ala Val Arg Asn ccc Pro 285 atg ttt tat ctc Met Phe Tyr Leu g cg Ala 290 931 979 1027 ctg cgg Leu Arg 295 att ccg ttg gtt Ile Pro Leu Val att ttg gcg Ile Leu Ala 300 acc atc gct Thr Ile Ala 305 acg gtg atc gca Thr Val Ile Ala caq gcc gtq att Gin Ala Val Ile tct Se r 315 gqt gcg tat tca Gly Ala Tyr Ser acc aag cag gcc Thr Lys Gin Ala 1075 1123 aat ttg aaa ctg Asn Leu Lys Leu ctg Leu 330 cca cgc atg gtg Pro Arg Met Val atc Ile 335 cgg cat acc tcc Arg His Thr Ser cgc aaa Arg Lys 340 gag gaa ggc Giu Giu Gly tcc gtg atg Ser Val Met 360 cag Gin 345 atc tat atg cca Ile Tyr Met Pro ctg Le u 350 gtt aat gga ttg Val Asn Gly Leu ctg ttt gta Leu Phe Val 355 agc ctc gcc Ser Leu Ala 1171 1219 gtt gtg gtg ctg Val Val Val Leu ttc cga tcc tct Phe Arg Ser Ser ga a Gi u 370 agc gcg Ser Ala 375 tac qga ctt gca Tyr Gly Leu Aia acc gga acc ttg Thr Gly Thr Leu Ctg gtc agc gtc Leu Val Ser Val ctg Leu 390 tat ctg atc tat Tyr Leu Ilie Tyr gt t Val1 395 cac acc aca tgg His Thr Thr Trp aaa aca gcq ctg Lys Thr Ala Leu ttc Phe 405 1267 1315 1363 att gtg ctc atc Ile Val Leu Ile ggt Gly 410 att cca gaa gta Ile Pro Giu Val ctt Leu 415 cta ttc gcc tcg Leu ?he Ala Ser aac acc Asn Thr 420 acq aaa att Thr Lys Ile ctc atc gtg Leu Ile Val 440 gac ggt ggC tgg Asp Gly Gly Trp cca cta ctt att Pro Leu Leu Ile gcg gCC gtg Ala Ala Val 435 cqc gtc aat Arg Val Asn 1411 gtg atg cgg acc tgg gag tgg gga agt Val Met Arg Thr Trp Giu Trp Gly Ser gac Asp 450 cag gaa Gin Glu 455 cgc gca gag ctg Arg Ala Glu Leu gaa Glu 460 ctt ccc atg gat Leu Pro Met Asp ttc ttg gag aaa Phe Leu Glu Lys 1459 1507 1555 1603 gat cag cca cac Asp Gin Pro His att ggt ctg cgt Ile Gly Leu Arg aaa Lys 480 gtt gcc gaa gtg Val Ala Giu Val gta ttt cca cat Val Phe Pro His qgc Gly 490 acc agc gat act Thr Ser Asp Thr ccg ttg tca ttg Pro Leu Ser Leu gtt cgc Val Arg 500 tgc gtg aaa Cys Val Lys atc gtc caa Ilie Vai Gin 520 ctc aag ctt tta Leu Lys Leu Leu cga gag atc gtg Arg Giu Ile Val atc gtt cga Ile Val Arg 515 cyc gcg gaa Arg Ala Giu 1651 1699 gaa cac qtt cog Giu His Val Pro gtq cca cca gag Val Pro Pro Giu gaa Giu 530 atg gaa Met Glu 535 gtg ctc cat cac Val Leu His His ccg atc aga gtc Pro Ile Arg Vai gtg Val1 545 cga gtt gat ctg Arg Val Asp Leu ctt ggt tat ttt Leu Gly Tyr Phe ga t Asp 555 gag cag aac ctg Glu Gin Asn Leu gag cat ctc cat Giu His Leu His 1747 1795 1843 att gac cca aca Ile Asp Pro Thr gat aac gcc acc Asp Asn Ala Thr ttc ctg tct gcc Phe Leu Ser Ala ctg act Leu Thr 580 ctt cqg agc Leu Arg Ser tat ctt tcg Tyr Leu Ser 600 agg Arg 585 ttg cct qga aag Leu Pro Gly Lys att Ile 590 got gqc tqg cgt Ala Gly Trp Arg gat cgt ttg Asp Arg Leu 595 tct ttc aaa Ser Phe Lys 1891 1939 atg qaa cgt aat Met Giu Arg Asn cag Gin 605 gca tct cga act Ala Ser Arg Thr gag Giu 610 ttg caa Leu Gin 615 cca agc aaa acc Pro Ser Lys Thr atc Ile 620 acg gtt gga aca Thr Val Gly Thr ctg cac ctt Leu His Leu 1984 taatcaggca gttgctggcc aac 2007 <210> 550 <211> 628 <212> PRT <213> Corynebacteriun giutamicun <400> 550 Met Ser Asp Gin Ser Met Le u Val1 Thr Ser 145 Ile Al a G ly Pro ValI 225 Tyr Phe Ala Leu Ala 305 Thr Leu Gly Ile His Met Leu Val1 Ala Pro 130 Pro Ala Phe Ile His 210 Leu Ala Cys Leu Ala 290 Thr Lys Asfl Gin Gi y As n Val1 Val1 Ala Gly Al a Ser Ile Gly Pro 195 T rp Le u Asp Val1 Val1 275 Pro Val Gin Met Le u Ser ValI Trp Arg Le u Leu Ser Giu Ala 165 Ile Ile Leu Al a Gi y 245 Met Asn Gly Ala Val1 Lys Le u Pro Glu Thr 70 Al a Lys Gi y Val1 Arq 150 Ile Met Ile Arg Val1 230 His Pro Gin Leu Ser 310 Asn Al a Le u Tyr 40 Th r Thr As n Ar g Al a 120 Ser Ile Pro Le u His 200 Ile Leu Gi y Leu Gi u 280 Ile Al a Lys Arq Gi y Ser Gin Le u Gin Gly 105 Le u Al a Le u Leu Trp 185 Pro Val1 Thr Al a Ile 265 Ala Pro Val1 Leu Pro 10 Al a Le u Glu Ile Gi y 90 His Phe Thr Pro Gly 170 Phe Glu Al a Val1 Arg 250 Leu Val1 Leu Ile Leu Lys Le u His As n Val1 75 Gin Trp Tyr Glu ValI 155 Thr Val1 Ile Glu Th r 235 Pro Th r Ar g Val1 Ser 315 Pro Ser Gly Thr Val1 Thr Gly Gly Gly Gly 140 Ser Glu Thr Leu Pro 220 Gly Ile Tyr As n Ile 300 Gi y Arg Val1 Val1 Al a T yr Val1 Gly Lys Asp 125 Le u Le u Lys Leu Gin 205 Phe Ala Arg Leu Pro 285 Leu Ala Met Al a Val1 Phe Gly L ys Ile Phe 110 Val1 Thr Ala Val1 Ala 190 Se r Gin Glu Val1 Gly 270 Met Al a Tyr Val1 Pro Phe Ser Ile Tyr Leu ValI Vali ValI Val1 Gly 175 Gly Leu Ala Ala Al a 255 Gin Phe Thr Ser Ile Lys Gly Met Ile Val1 Al a Al a Ile Ile Leu 160 Lys Leu Se r Phe Leu 240 Trp Gly Tyr Ile Le u 320 Arg His Thr Ser Arg 340 Gly Leu Leu Phe 355 Ser Glu Ser Leu 37 0 Val Leu Val Ser 385 Lys Thr Ala Leu Phe Ala Ser Asn 420 Leu Ile Ala Ala 435 Ser Asp Arg Val 450 Lys Phe Leu Glu 465 Val Ala Glu Val Leu Ser Leu Val 500 Ile Val Ile Val 515 Glu Giu Arg Ala 530 Val Arg Val Asp 545 Giu His Leu His Leu Ser Ala Leu 580 Trp Arg Asp Arg 595 Thr Glu Ser Phe 610 Giu Leu His Leu 625 <210> 551 325 Lys Val1 Ala Val1 Phe 405 Thr Val1 Asn Lys Al a 485 Arg Arg Glu Leu Ala 565 Thr Leu Lys Glu Ser Se r Le u 390 Ile Thr Le u Gin Leu 470 ValI Cys Ile Met His 550 T.i1e Leu Tyr Glu Val1 Ala 375 Tyr Val1 Lys Ile Glu 455 Asp Phe Val1 Val1 Glu 535 Le u Asp Arg Leu Gly Met 360 Tyr Le u Leu Ile Val1 440 Arg Gin Pro Lys Gin 520 Val1 Gl y Pro Ser Ser 600 Gin 345 Val1 Gly Ile Ile His 425 Val1 Al a Pro His Asp 505 Giu Leu Tyr Thr Arg 585 Met 330 Ile Val1 Leu Tyr Gly 410 Asp Met Giu His Gly 490 Leu His His Ph e Trp 570 Leu Glu Tyr Val1 Al a Val1 395 Ile Gly Arg Le u Asn 475 Thr Lys Val His Asp 555 Asp Pro Arq Met Le u Val1 380 His Pro Gly Thr Giu 460 Ile Ser Leu Pro Ala 540 Glu As n Gly As n Pro Val1 365 Thr Thr Glu Trp Trp 445 Leu Gly Asp Leu His 525 Pro Gin Ala Lys Gin 605 Le u 350 Ph e Gly Thr Val1 Le u 430 Glii Pro Le u Thr T yr 510 ValI Ile Asn Thr Ile 590 Ala 335 Val1 Arg Thr Trp Le u 415 Pro Trp Met Arg Val 495 Arg Pro Arg Leu T yr 575 Ala Ser As n Ser Le u Trp 400 Leu Leu Giy Asp Lys 480 Pro Glu Pro Val1 Pro 560 Phe Gly Arq Leu Gin Pro Ser Lys Thr Ile Thr Vai Gly Thr <211> <212> <213> <220> <221> <222> <223> 1035 DNA Coryriebacterium glutamicum CDS (1012) RXN0 0297 <400> 551 aacaaggcac cggaaaacaa gcaacgcacc ttgcagaggt ggtcttaagc atcttggagc aaaacaacat ggcacaataa cgatcatgca acaggtgctc atg ggt ttc acg gtg Met Gly Phe Thr Val gtg ttc atc gtc Val Phe Ile Val gga ata ggt tgg Gly Ile Gly Trp ctc ggt aga aga Leu Gly Arg Arg gac acc Asp Thr ttg ggc aca Leu Gly Thr 9CC acC cca Ala Thr Pro cat His gcc cag aaa cct Ala Gin Lys Pro agc ctq ttt qtc Ser Leu Phe Val tat tac qtg Tyr Tyr Val gat acc tcg Asp Thr Ser gcg ttg ttg ttt Ala Leu Leu Phe qa t Asp 45 cgg gtc aco aag Arg Val Thr Lys tca Se r acg att Thr Ile ttc tct ctg aac Phe Ser Leu Asn ttc Phe qtg gtc att gca Val Val Ile Ala tct gog ttg atc Ser Ala Leu Ile qgt ttc ctg ttt Gly Phe Leu Phe ttc Ph e cta ctc atg cgg Leu Leu Met Arg gtg atc aaa aga Val Ile Lys Arg 307 355 403 gcc gca gta tcg Ala Ala Val Ser ato qqc atg cta Ile Giy met Leu gcg tcc tac gcc Ala Ser Tyr Ala aac gcc Asn Ala 100 gqt aac ctg Gly Asn Leu qtg gtg att Val Val Ile 120 atc cot ttg qca Ilie Pro Leu Ala tat att ttg gat Tyr Ile Leu Asp gat ttc acc Asp Phe Thr 115 gca 009 atc Ala Pro Ile ccc gtg att. ttg Pro Val Ile Leu ttC Ph e 125 cag gtg gcg ttc Gin Val Ala Phe aoc atg Thr Met 135 acc etc atg gag Thr Ile Met Glu ctg acc eac aag Leu Thr Asn Lys tco acc aac ttg Ser Thr Asn Leu cgc aac ctc ctg Arg Asn Leu Leu acg cca cta acc Thr Pro Leu Thr ac As n 160 acc atg gtg oto Thr Met Val Leu gca Ala 165 gog att 9CC ggt Ala Ile Ala Gly got gtg tct ttg Ala Val Ser Leu act Thr 175 tcg atg agc gtg Ser Met Ser Val ccc gtg Pro Val 180 gtg att gct cag cca gtg gee atg ttg gcg eat got tce gtg cca ctg Val Ile Ala Gin Pro Val Giu Met Leu Ala Asn Ala Ser Val Pro Leu 185 190 195 gct ttg gtg gtg ttc gqa ctg tcc ttg toc aag agc aag atc ctg gaa 739 Ala Leu Val Val Phe Gly Leu Ser Leu Ser Lys Ser Lys Ile Leu Glu 200 205 210 aag qgg cag gta too agg cgc gat gtg ttt acg gcg gca ctg ttc aag 787 Lys Gly Gin Val Ser Arg Arg Asp Val Phe Thr Ala Ala Leu Phe Lys 215 220 225 aat gtt ctg cac cca att. gtt gcg qga ctt tta gcc tta gcc ttt ggt 835 Asn Val Leu His Pro Ile Val Ala Gly Leu Leu Ala Leu Ala Phe Giy 230 235 240 245 atg gaa ggt act goc ttg ttq tcq gcg gtg att ctc ggt gca ctq oca 883 Met Glu Gly Thr Ala Leu Leu Ser Ala Val Ile Leu Gly Ala Leu Pro 250 255 260 aca gcg cag aat gtc tac aco tac qog ttg cga ttt aga aca got gaa 931 Thr Ala Gin Asn Val Tyr Thr Tyr Ala Leu Arq Phe Arq Thr Ala Giu 265 270 275 tcg atg gog aga gac aca ggg gtg gtc acc aca cto att. too ttc 000 979 Ser Met Ala Arq Asp Thr Gly Val Val Thr Thr Leu Ile Ser Phe Pro 280 285 290 qta ttg gtg gcg gtc tcc att atc ttt gqa tct taggqttagc attaqtggtc 1032 Val Leu Val Ala Val Ser Ile Ile Phe Gly Ser 295 300 atg 1035 <210> 552 <211> 304 <212> PRT <213> Corynebacterium glutarnicum <400> 552 Met Gly Phe Thr Val Val Phe Ile Vai Ile Gly Ile Giy Trp Ile Leu 1 5 10 Gly Arg Arg Asp Thr Leu Gly Thr His Ala Gin Lys Pro Leu Ser Leu 25 Phe Val Tyr Tyr Val Ala Thr Pro Ala Leu Leu Phe Asp Arg Val Thr 40 Lys Ser Asp Thr Ser Thr Ile Phe Ser Leu Asn Phe Val Val Ile Ala 55 Leu Ser Ala Leu Ile Val Gly Phe Leu Phe Phe Leu Leu Met Arg Phe 70 75 Val Ile Lys Arg Thr Ala Ala Val Ser Val Ile Giy Met Leu Ala Ala 90 Ser Tyr Ala Asn Ala Gly Asn Leu Giy Ile Pro Leu Ala Ala Tyr Ile 100 105 110 Leu Asp Asp Phe Thr Val Val Ile Pro Val Ile Leu Phe Gin Val Ala 115 120 125 Phe Tyr Ala Pro Ilie Thr Met Thr Ile Met Glu Met Leu Thr Asn Lys 130 135 140 Lys Ser Thr Asn Leu Val Arg Asn Leu Leu Val Thr Pro Leu Thr Asn 145 150 155 160 Thr Met Val Leu Ala Ala Ile Ala Gly Ile Ala Val Ser Leu Thr Ser 165 170 175 Met Ser Val Pro Val Val Ile Ala Gin Pro Val Giu Met Leu Ala Asn 180 185 190 Ala Ser Val Pro Leu Ala Leu Val Val Phe Gly Leu Ser Leu Ser Lys 195 200 205 Ser Lys Ile Leu Giu Lys Gly Gin Vai Ser Arg Arg Asp Vai Phe Thr 210 215 220 Ala Ala Leu Phe Lys Asn Val Leu His Pro Ile Val Ala Giy Leu Leu 225 230 235 240 Ala Leu Ala Phe Gly Met Giu Gly Thr Ala Leu Leu Ser Ala Val Ile 245 250 255 Leu Gly Ala Leu Pro Thr Ala Gin Asn Val Tyr Thr Tyr Ala Leu Arg 260 265 270 Phe Arq Thr Ala Glu Ser Met Ala Arg Asp Thr Gly Val Val Thr Thr 275 280 285 Leu Ile Ser Phe Pro Val Leu Val Ala Val Ser Ile Ile Phe Gly Ser 290 295 300 <210> 553 <211> 353 <212> DNA <213> Corynebacterium glutamicum <2 <221> CDS <222> (101)..(343) <223> RXN03103 <400> 553 atcttcagaq tcacttcttt cagtgtcatt tttctcggcc ctaatccccc gctggagttc aatcagcgat tgcaaccttt tagatatata aggagacaac atg tct gca aag cgt 115 Met Ser Ala Lys Arg 1 act ttt acc cqt atc ggt qcg att ctt gga gca act gca ctt gCC gga 163 Thr Phe Thr Arg Ile Gly Ala Ile Leu Gly Ala Thr Ala Leu Ala Giy 15 gtaoc ctc Val Thr Leu goa qcc att Ala Ala Ilie ac Thr qoc tgt ggt gat Ala Cys Gly Asp t ca Ser 30 ago gqt qgc Ser Gly Gly gaa aat ggt tot Glu Asn Gly Ser aat gto ggo aoo Asn Val Gly Thr gao qga tto oto Asp Gly Phe Leu aaa tao gat oag Lys Tyr Asp Gin ago ggt oto gao Ser Gly Leu Asp tgatgacaag 211 oct ggt Pro Gly ott ggo otc ogo Leu Gly Leu Arg ooa gao aao too Pro Asp Asn Ser gtg Val gat gtt got gaa Asp Val Ala Giu gta att oaa oto Val Ile Gin Leu oat ogo His Arg <210> 554 <211> 81 <212> PRT <213> Corynebaoterium glutamioum <400> 554 Met Ser Ala Lys Arg 1 5 Thr Phe Thr Arg Gly Ala Ile Leu Gly Ala Thr Ala Leu Giy Asp Gly Ala Gly Val Thr Leu Ala Cys Giy Asp Ser Ser Gly Asn Vai Gly Phe Leu Ala Ala Glu Asn Gly Ser Thr Lys Tyr Asp Gin Pro Leu Gly Leu Arg Pro Asp Asn Ser Met Arg Ser Gly Leu Asp Asp Val Ala Glu T yr Val Ile Gin Leu <210> <211> <212> <213> <220> <221> <222> <223> 555 695 DNA Corynebacterium giutamioum CDs RXN02 993 <400> 555 qtt got gaa tao gta gtc aao too ato Val Ala Glu Tyr Val Val Asn Ser Ile 1 5 oao 000 aoo ato gaa tgg ogt gaa too His Pro Thr Ilie Giu Trp Arg Glu Ser 25 got Al a 10 gat gao aag ggo Asp Asp Lys Gly tgg gat Trp Asp oot tot gog oag Pro Ser Ala Gin ogt gaa ac Arg Giu Thr otc att caa Leu Ile Gin aac ggt gag gta Asn Gly Glu Val ga c Asp atg atc qca gca Met Ile Ala Ala tao tcc ato Tyr Ser Ile aac gct Asn Ala ggc ogt tca gag Gly Arg Ser Glu gto aac ttc ggt Val Asn Phe Gly cca tac ctg ctt Pro Tyr Leu Leu cac cag got ctg His Gin Ala Leu gtt. cgc oaa gat Val Arg Gin Asp gat cgc att gaa Asp Arg Ile Giu ac Thr otc gag gac ttg Leu Giu Asp Leu ga t Asp aac ggt ttg atc Asn Giy Leu Ile Ct g Le u 90 tgo tcc gtt tc Cys Ser Vai Ser gga too Giy Ser act oca got Thr Pro Ala gaa tao gao Giu Tyr Asp 115 aag gtc aag gat Lys Val Lys Asp otc cca ggc gtt Leu Pro Gly Val cag ctc caa Gin Leu Gin 110 oag ggc aac Gin Gly Asn acc tao tct tco Thr Tyr Ser Ser tgt Cys 120 gtt gag gca ctg Val Giu Ala Leu gtt gac Val Asp 130 gcc ctg acc act Ala Leu Thr Thr gac Asp 135 goc aco atc ctc Ala Thr Ile Leu ggc tac too cag Gly Tyr Ser Gin tac gaa ggc gao Tyr Giu Gly Asp cgo gtt gtg gaa Arg Val Val Glu gaa aag gac ggc Glu Lys Asp Gly gag Glu 160 oca ttc acc gac Pro Phe Thr Asp gag Giu 165 tac tac ggo att Tyr Tyr Gly Ile ctg aag aag gat Leu Lys Lys Asp gac oag Asp Gin 175 gaa ggc acc Giu Gly Thr ggc aco ttc Giy Thr Phe 195 gao Asp 180 got atc aao gco Ala Ile Asn Ala gca Ala 185 ott gag ogo atg Leu Giu Arg Met tao got gao Tyr Ala Asp 190 gac too gtg Asp Ser Val cag oga otg oto Gin Arg Leu Leu gag aao oto ggt Giu Asn Leu Gly gtt gtt Val Vai 210 gaa gaa ggo aoo Giu Giu Gly Thr ggt gao oto too Giy Asp Leu Ser oto gao goa ago Leu Asp Ala Ser tagtgtgaog gcttttaaaa gco 695 <210> 556 <211> 224 <212> PRT <213> Corynebaoterium glutamioui <400> 556 Val Ala Glu Tyr Val Val Asn Ser IleAla Asp Asp Lys Gly Trp Asp His Pro Thr Ile Glu Trp Arg Giu Ser Pro Ser Ala Gin Arg Giu Thr 25 Leu Ile Gin Asn Giy Giu Val Asp Met Ile Ala Ala Thr Tyr Ser Ile 40 Asn Ala Gly Arg Ser Glu Ser Val Asn Phe Gly Gly Pro Tyr Leu Leu 55 Thr His Gin Ala Leu Leu Val Arg Gln Asp Asp Asp Arg Ile Glu Thr 70 75 Leu Glu Asp Leu Asp Asn Gly Leu Ile Leu Cys Ser Val Ser Gly Ser 90 Thr Pro Ala Gin Lys Val Lys Asp Val Leu Pro Gly Val Gin Leu Gin 100 105 110 Giu Tyr Asp Thr Tyr Ser Ser Cys Val Glu Aia Leu Ser Gin Giy Asn 115 120 125 Val Asp Ala Leu Thr Thr Asp Ala Thr Ile Leu Phe Gly Tyr Ser Gin 130 135 140 Gin Tyr Glu Gly Asp Piie Arg Vai Val Giu Met Glu Lys Asp Gly Glu 145 150 155 160 Pro Phe Thr Asp Glu Tyr Tyr Gly Ile Gly Leu Lys Lys Asp Asp Gin 165 170 175 Gin Giy Thr Asp Ala Ilie Asn Ala Ala Len Giu Arq Met Tyr Ala Asp 180 185 190 Gly Thr Phe Gin Arg Leu Leu Thr Giu Asn Len Giy Giu Asp Ser Val 195 200 205 Val Val Gin Gin Gly Thr Pro Gly Asp Leu Ser Phe Len Asp Ala Ser 210 215 220 <210> 557 <211> 1590 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1567) <223> RXN00349 <400> 557 tgtgtacatc acaatggaat tcggggctag aqtatctggt gaaccgtgca taaacgacct gtgattggac tctttttcct tgcaaaatgt tttccaqcqg atg ttg agt ttt gcg 115 Met Leu Ser Phe Ala 1 acc ctt cgt ggc cqc att tca aca gtt gac gct gca aaa gcc gca cct 163 Thr Leu Arg Gly Arg Ile Ser Thr Vai Asp Ala Ala Lys Ala Ala Pro ccg cca tcg Pro Pro Ser gcc ggt gtg Ala Giy Val cca Pro cta gcc ccg att Leu Ala Pro Ile ctc act gac cat Leu Thr Asp His agt caa gtg Ser Gin Vai ttg ctt tct Leu Leu Ser atg aat ttg gct Met Asn Leu Ala aga att ggc gat Arg Ile Gly Asp tca ggt Ser Giy acg tca aat agt Thr Ser Asn Ser acc aag gta caa Thr Lys Val Gin gtt Val1 cga gca gtg acc Arg Ala Val Thr t ct Se r gcg tac ggt ttg Ala Tyr Gly Leu tac Tyr 75 tac acq cac gtg Tyr Thr His Val atc acg ttg aat Ile Thr Leu Asn acg Thr ato acc atc ttc Ile Thr Ile Phe aac atc ggt gtg Asn Ile Gly Val gag Giu agg aag atg ccg Arq Lys Met Pro gtc aac Val Asn 100 gtg ttt cat Val Phe His gag qtt gac Giu Val Asp 120 gtt Val 105 gta ggc aag ttg Val Gly Lys Leu gac Asp 110 acc aac ttc tcc Thr Asn Phe Ser aaa Ctg tct Lys Leu Ser 115 acc ccg cct Thr Pro Pro 451. 499 cgt ttg atc cgt Arg Leu Ile Arg att cag gct ggt Ile Gin Ala Gly gag gtt Giu Val 1.35 gcc gag aaa atc Ala Giu Lys Ilie gac gag ttg gag Asp Giu Leu Giu tcc cct gcg tct Ser Pro Ala Ser tat Tyr 150 ggt ttc cct gtt Gly Phe Pro Val gcg Ala 155 ttg ctt ggc tgg Leu Leu Gly Trp gca Al a 160 atg atg ggt ggt Met Met Gly Gly 547 595 643 gtt gct gtg ctg Val Ala Val Leu ttg Leu 170 ggt ggt gga tgg Giy Gly Gly Trp gtt tcc cta att Val Ser Leu Ile gct ttt Aia Phe 180 att acc gcg Ile Thr Ala gqt ttg cct Gly Leu Pro 200 acg ato att gcc Thr Ile Ile Ala acg tca ttt Thr Ser Phe ttg gga aag aag Leu Gly Lys Lys .195 act ttc ttc caa Thr Phe Phe Gin gtt gtt ggt qgt Val Val Gly Gly att gcc acg Ile Ala Thr ctg cct Leu Pro 215 gca tcg att gct Ala Ser Ile Ala tat Tyr 220 tct ttg gcq ttg Ser Leu Ala Leu caa Gin 225 ttt ggt ctt gag Phe Gly Leu Giu aaa ccg agc cag Lys Pro Ser Gin atc Ile 235 atc gca tct gga Ile Ala Ser Gly gtt gtg ctg ttg Val Val Leu Leu 787 835 883 ggt ttg aca ctc Giy Leu Thr Leu caa tct ctg cag Gin Ser Leu Gin ggc atc acg ggc Gly Ile Thr Gly gct ccg Ala Pro 260 qtg aca gca Val Thr Ala att gtt gct Ile Vai Ala 280 agt Ser 265 gca cga ttt ttc Ala Arg Phe Phe ga a Giu 270 aca ctc ctg ttt Thr Leu Leu Phe acc ggc ggc Thr Gly Gly 275 atc ttg ca-t Ile Leu His ggc gtg ggt ttg Gly Val Giy Leu att cag ctt tct Ile Gin Leu Ser 979 gtc atg Val Met 295 ttg cct gcc atg Leu Pro Ala Met tcc gct gca gca Ser Ala Ala Ala cct Pro 305 aat tat tcg tct Asn Tyr Ser Ser ttc gcc cgc att Phe Ala Arg Ile atc Ile 315 gct ggt ggc gtc Ala Gly Gly Val gca gcg gcc ttc Ala Ala Ala Phe 1027 1075 1123 gtg ggt tgt tac Val Giy Cys Tyr gag tgg tcc tcg Giu Trp Ser Ser att att gcg ggg Ilie Ile Ala Gly ctt act Leu Thr 340 gcg ctg atg Ala Leu Met ccc qtC tct Pro Val Ser 360 ggt Gi y 345 tct gcg ttt tat Ser Ala Phe Tyr tac T yr 350 ctc ttc gtt gtt Leu Phe Val Val tat tta ggc Tyr Leu Gly 355 ttc act ggt Phe Thr Gly 1171 1219 gcc gct qcg att Ala Ala Ala Ile gca aca gca gtt Ala Thr Ala Val ggt ttg Gly Leu 375 ctt qcc cgt cga Leu Ala Arg Arg ttg att cca ccg Leu Ie Pro Pro ttg Le u 385 att gtq qcg att Ile Val Ala Ile gcc Ala 390 ggc atc aca cca Gly Ile Thr Pro atg Met 395 ctt cca ggt cta Leu Pro Gly Leu gca Ala 400 att tac cgc gga Ile Tyr Arg Gly atg Met 405 1267 1315 1363 tac gcc acc ctg Tyr Ala Thr Leu aat Asn 410 gat caa aca ctc Asp Gin Thr Leu ggt ttc acc aac Gly Phe Thr Asn att gcg Ile Ala 420 gtt gct tta Val Ala Leu gag tgg att Glu Trp Ile 440 gcc Al a 425 act gct tca tca Thr Ala Ser Ser gcc gct, ggc gtg Ala Ala Gly Val gtt ttg ggt Val Leu Giy 435 aac cca tac Asn Pro Tyr 1411 1459 gcc cgc agg cta Ala Arg.Arg Leu cgt cca cca cgc Arg Pro Pro Arg ttc Phe 450 cgt gca Arg Ala 455 ttt acc aag gcg Phe Thr Lys Ala aat Asn 460 gag ttc tcc ttc Giu Phe Ser Phe cag Gin 465 gag gaa gct gag Glu Giu Ala Giu 1507 1555 cag Gin 470 aat cag cgc cgg Asn Gin Arg Arg aga aaa cgt cca Arg Lys Arg Pro act aat cag aga Thr Asn Gin Arg ggt aat aaa agg taaaaatcaa cctgcttagg cgt 1590 Gly Asn Lys Arg <210> 558 <211> 489 <212) PRT <213> Corynebacterium giutaniicum <400> 558 Met Leu Ser 1 Ala Lys Ala Asp His Ser Asp Ile Leu Val Arg Ala Ile Thr Leu Lys Met Pro Phe Ser Lys 115 Gly Ala Thr 130 Gin Ser Pro 145 Met Met Gly Ser Leu Ile Phe Leu Gly 195 Gly Phe Ile 210 Gin Phe Gly 225 Vai Val Leu Ile Thr Gly Phe Ala Thr 5 Ala Pro Pro Gin Val Ala Leu Ser Ser Vai Thr Ser 70 Asn Thr Ilie Val Asn Val 100 Leu Ser Giu Pro Pro Glu Ala Ser Tyr 150 Gly Ala Val 165 Ala Phe Ilie 180 Lys Lys Gly Ala Thr Leu Leu Glu Ile 230 Leu Ala Gly 245 Ala Pro Val 260 Leu Arg Gly Arg Ilie Ser Thr Val Pro Ser Gly Val 40 Gly Thr 55 Ala Tyr Thr Ile Phe His Val Asp 120 Val Ala 135 Gly Phe Ala Val Thr Ala Leu Pro 200 Pro Ala 215 Lys Pro Leu Thr Thr Ala Pro 25 Met Se r Gly Ph e Val 105 Arq Giu Pro Leu Ph e 185 Th r Ser Ser Le u Ser 265 10 Leu Asn As n Leu Thr 90 Val1 Leu Lys Val Leu 170 Thr Phe Ile Gin ValI 250 Ala Al a Leu Ser Tyr 75 As n Gi y Ile Ile Al a 155 Gly Ilie Phe Al a Ile 235 Gin Arg Pro Ala Asp Tyr Ile Lys Arg Le u 140 Leu Gly Ile Gin T yr 220 Ile Ser Phe Ile Ala Thr Thr Gly Leu S er 125 Asp Leu Gly Ala As n 205 Ser Al a Leu Ph e Asp Arg Lys His Val Asp 110 Ile Giu Gly Trp Thr 190 Val1 Leu Ser Gin Giu 270 Asp Leu Ile Val1 Val Giu Thr Gin Leu Trp Gin 175 Thr Val Ala Gly Asp 255 Thr Al a Th r Gly Gin Asp Arg As n Al a Glu Ala 160 Val1 Se r Gi y Leu Ilie 240 Gly Leu Leu Phe Thr Gly Gly Ile Val Ala Gly Val Gly Leu Gly Ile Gin Leu Ser Gu Ile Leu His Val Met Leu Pro Ala Met Glu Ser Ala Ala Ala 290 295 300 Pro Asn Tyr Ser Ser Thr Phe Ala Arg Ile Ile Ala Gly Gly Val Thr 305 310 315 320 Ala Ala Ala Phe Ala Val Gly Cys Tyr Ala Glu Trp Ser Ser Val Ile 325 330 335 Ile Ala Gly Leu Thr Ala Leo Met Gly Ser Ala Phe Tyr Tyr Leo Phe 340 345. 350 Val Val Tyr Leo Gly Pro Val Ser Ala Ala Ala Ile Ala Ala Thr Ala 355 360 365 Val Gly Phe Thr Gly Gly Leo Leo Ala Arg Arg Phe Leo Ile Pro Pro 370 375 380 Le Ile Val Ala Ile Ala Gly Ile Thr Pro Met Leo Pro Gly Leu Ala 385 390 395 400 Ilie Tyr Arg Gly Met Tyr Ala Thr Leu Asn Asp Gin Thr Leo Met Gly 405 410 415 Phe Thr Asn Ile Ala Val Ala Leo Ala Thr Ala Ser Ser Leo Ala Ala 420 425 430 Gly Val Val Leo Gly Glu Trp Ile Ala Arq Arg Leo Arg Arg Pro Pro 435 440 445 Arg Phe Asn Pro Tyr Arg Ala Phe Thr Lys Ala Asn Glu Phe Ser Phe 450 455 460 Gin Giu Glu Ala Gbu Gin Asn Gin Arg Arg Gin Arq Lys Arg Pro Lys 465 470 475 480 Thr Asn Gin Arg Phe Gly Asn Lys Arg 485 <210> 559 <211> 492 <212> DNA <213> Corynebacteriom glotamicum <220> <221> CDS <222> (469) <223> RXN03095 <400> 559 aacgcctcaa ttagtgccag accttgccga ccgcagacca aacttcacca tttcaaacca tccctagcca caacaacqgc agttgtgcaa tgatctgcgt atg aat gca gat aag 115 Met Asn Ala Asp Lys 1 aaa atg tgc qga atg aac ccq gat agc caa tac gtc gaa ctt gcc gtc 163 Lys Met Cys Gly Met Asn Pro Asp Ser Gin Tyr Val Glu Leo Ala Val 15 qaa gtt ttc gga ctc ctc gcg gac gcc act cga gtt cgc atc atc ttg 211 Giu Val Phe Gly Leu Leu Ala Asp Ala Thr Arg Val Arg Ile Ile Leu 30 gca ctt cga aac agt ggt gaa ctt tcc gta aac cac ctc gcg gac atc 259 Ala Len Arg Asn Ser Gly Glu Leu Ser Val Asn His Leu Ala Asp Ile 45 gtc gat aaa toc ccc qca gca gtt tcc caa cac ctc gcc cgg ctg cqc 307 Val Asp Lys Ser Pro Ala Ala Val Ser Gin His Leu Ala Arg Leu Arg 60 atg gcc cga atc gtg tcc acc cgt caa gaa ggt caa cga gtt ttc tac 355 Met Ala Arg Ile Vai Ser Thr Arg Gin Giu Gly Gin Arg Val Phe Tyr 75 80 aaa ctc acc aat gaa cac gca tca cag cta gtc tcc gac gct att ttt 403 Lys Leu Thr Asn Giu His Ala Ser Gin Leu Val Ser Asp Ala Ile Phe 95 100 cag gcg gaa cac acc att gcg gac ggc cag act ccc cca cac cac cac 451 Gin Ala Gin His Thr le Ala Asp Gly Gin Thr Pro Pro His His His 105 110 115 cga gaa cga gaa caa tca tgaccaccca cagtcaccaa gaa 492 Arg Glu Arg Giu Gin Ser 120 (210> 560 (211> 123 <212> PRT (213> Corynebacterium giutamicum <400> 560 Met Asn Ala Asp Lys Lys Met Cys Gly Met Asn Pro Asp Ser Gin Tyr 1 5 10 Val Giu Leu Ala Val Giu Vai Phe Gly Leu Leu Ala Asp Ala Thr Arg 25 Vai Arg Ile Ile Leu Ala Len Arg Asn Ser Gly Giu Leu Ser Val Asn 40 His Leu Ala Asp Ile Val Asp Lys Ser Pro Ala Ala Val Ser Gin His s0 55 Leu Ala Arg Leu Arg Met Ala Arg Ile Val Ser Thr Arg Gin Glu Gly 70 75 Gin Arg Val Phe Tyr Lys Leu Thr Asn Giu His Ala Ser Gin Leu Val 90 Ser Asp Ala Ile Phe Gin Ala Giu His Thr Ile Ala Asp Gly Gin Thr 100 105 110 Pro Pro His His His Arg Giu Arg Giu Gin Ser 115 120 <210> 561 <211> <212> <213> <220> <221> <222> <223> 591 DNA Corynebacterium glutamicum COS (101)..(568) RXN0 3160 <400> 561 gagcatatgg tgcgcgcggc cgatatgctg atcaattcea accccgatce gcacgcttaa cttctgccaa aaagtcgttt tgaccataag ctaagcgatt gtg aat cga att Val Asn Arg Ile gaa atc gca cgc Glu Ilie Ala Arg ttc ggc gtg ctg Phe Gly Val Leu gge Gly ttc age get tte Phe Ser Ala Phe 9gc gge Giy Gly ccc ace gcg Pro Thr Ala ege tgg etg Arg Trp Leu ea c His etc gga tat ttc Leu Gly Tyr Phe acg gaa ttc qtg Thr Glu Phe Val gag egg cgg Glu Arq Arg ctc agc caa Leu Ser Gin gat gat ege caa Asp Asp Arg Gin tee gag ate gta Ser Giu Ile Val g cg Ala eta ctt Leu Leu ccc gga cct gga Pro Gly Pro Gly t eg Ser teg cag gte ggt Ser Gin Val Gly atg ctg ggc tac Met Leu Gly Tyr cgc gee ggt ttt Arg Ala Gly Phe gge atg gcg ate Gly Met Ala Ile tgg ctc atg ttt Trp Leu Met Phe ace Thr 307 355 403 tgg eec tea ttg Trp Pro Ser Leu ctc atg geg geg Leu Met Ala Ala gee etg ett ttt Ala Leu Leu Phe gat gcg Asp Ala 100 ace tee gee Thr Ser Ala gtt tte aaa. Val Phe Lys 120 age tgg acg etc ggc etg ctc gcc gea geg gte gee gte Ser Trp Thr Leu Gly Leu Leu Ala Ala Ala Val Ala Val 105 110 115 ege agt cac egg Arg Ser His Arg gea Ala 125 tgg ege ggt tea Trp Arg Gly Ser get tee aeg Ala Ser Thr Ceg ggg Pro Gly 135 ege egg eca eca Arg Arg Pro Pro t eg Ser 140 ggg gte gge ete Gly Val Giy Leu gca teg egg gtg Ala Ser Arg Val etc Leu 150 gge cet ce eaa Gly Pro Pro Gin egg ggt Arg Cly 155 taaeaeacet tggggttcaa tea <210> 562 <211> 156 <212> PRT (213> Corynebacterium giutarnicum <400> 562 Val Asn Arg 1 Ser Ala Phe Phe Val Glu Val Ala Leu Met Met Leu Trp Leu Met Leu Leu Phe Ala Ala Val 115 Ser Met Ala 130 Gly Ala Ser 145 (210> 563 <211> 645 Ile Gly Arg Ser Gly Phe Asp 100 Ala Ser Ala Al a Leu 40 Pro Ala Ser Ala Lys 120 Arg Arg His Asp Gly Gly Leu Ser 105 Arg Arg S er 10 Leu Asp Pro Phe Ala Trp Ser Pro Gly Tyr Gin Ser Gly Met Le u Arg Ser 140 Val1 Ph e Tyr Ser Met Ala Gly Ala 125 Gly Gly Thr Glu Val1 Ile Phe Le u Arg Gly Phe Giu Ile Gly Ala Al a Ala Gly Leu Arg Val Leu Gly Pro Pro Gin.Arg Gly (212> DNA (213> Corynebacterium qiutamicum <220> (221> CDS (222> (101)..(622) <223> RXN02955 <400> 563 atgcactggc tcccatcaaa gacgaattct tgacctcaga aagcagtgcg cgccgctgat acttcaggag gtgcgqcatc tcc atc Ser Ile cac agc His Ser tgg cta Trp Leu gtg tgc gtc act qcc Val Cys Val Thr Ala cca tca acg tgg tct Pro Ser Thr Trp Ser tct ttc gca ggt aqt Ser Phe Ala Gly Ser cag Gin gaa Glu 30 ttc Phe gtq Val1 15 cta Leu ctc Leu ttt Phe tcc Ser ttt Ph e attccagcgt gaactctacg atq atg aat ttt aag Met. Met Asn Phe Lys 1 agc cgc cag gtg ctg Ser Arg Gin Val Leu aaq ctg ttg ttc gtg Lys Leu Leu Phe Val gga gag cgt gqa cat Giy Glu Arg Gly His att gcg gtt gat ttc atc gcg cgc aaa ctg cct gtt tct gcg cag cgg 307 Ile Ala Val Asp Phe Ile Ala Arg Lys Leu Pro Val Ser Ala Gin Arg 60 gtc ctg cag gtc att gtt cag ttg ttg att gtt gtt ttt gog atc ctc 355 Val Leu Gin Vai Ile Val Gin Leu Leu Ile Val Vai Phe Ala Ile Leu 75 80 ggc atg atc tgg ggt ggc tac ttg gct gca tca atc gcg tgg aat cag 403 Gly Met Ile Trp Giy Giy Tyr Leu Ala. Ala Ser Ile Ala Trp Asn Gin 95 100 cag ctc act qcg ctg cca ctt acc ttg gqa tgg gtg tat gtt gtc atc 451 Gin Leu Thr Ala Leu Pro Leu Thr Leu Gly Trp Val Tyr Val Val Ile 105 110 115 ccg atc gcg ggt gtg ttc atc gcg ttq ttc gcg atc atc gat ctc atc 499 Pro Ile Ala Giy Val Phe Ile Ala Leu Phe Ala Ile Ile Asp Leu Ile 120 125 130 gaa gtg gcc aca ggc aag gaa gag cct tac ccc ctt gtt gat gaa tca 547 Giu Val Ala Thr Gly Lys Glu Glu Pro Tyr Pro Leu Val Asp Glu Ser 135 140 145 gaa gaa cct cga gat ttg gac gag cta gag gcc caa agc gct ata gat 595 Giu Glu Pro Arg Asp Leu Asp Glu Leu Glu Ala Gin Ser Ala Ile Asp 150 155 160 165 tct gca agt tca gcg gaa ggt agg aac taatatgttg tcgccagcag 642 Ser Ala Ser Ser Ala Giu Gly Arg Asn 170 ctg 645 <210> 564 <211> 174 <212> PRT <213> Corynebacterium glutamicum <400> 564 Met Met Asn Phe Lys Ser Ile Val Cys Val Thr Ala Trp Gin Val Phe 1 5 10 Ser Arg Gin Vai Leu His Ser Pro Ser Thr Trp Ser Glu Glu Leu Ser 25 Lys Leu Leu Phe Val Trp Leu Ser Phe Ala Giy Ser Ala Phe Leu Phe 40 Gly Glu Arg Gly His Ile Ala Val Asp Phe Ile Ala Arg Lys Leu Pro 55 Val Ser Ala Gin Arg Val Leu Gin Val Ile Val Gin Leu Leu Ile Val 70 75 Val Phe Ala Ile Leu Gly Met Ile Trp Gly Gly Tyr Leu Ala Ala Ser 90 Ile Ala Trp Asn Gin Gin Leu Thr Ala Leu Pro Leu Thr Leu Gly Trp Val Tyr Val 115 Ile Ile Asp 130 Leu Val Asp 145 Gin Ser Ala 100 105 Val Ile Pro Ile Ala Gly 120 Leu Ile Glu Val Ala Thr 135 Giu Ser Giu Glu Pro Arg 150 Ile Asp Ser Ala Ser Ser 165 110 Val Phe Ile Ala Leu Phe Ala 125 Gly Lys Glu Giu Pro Tyr Pro 140 Asp Leu Asp Giu Leu Giu Ala 155 160 Ala Glu Gly Arg Asn 170 <210> 565 <211> 754 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (754) <223> RXN03109 <400> 565 aotggcgctt cocgatggtc aatcattggc ctttggtgcc caaactgqcg agttgttgot cogcgcatcc cgcgaactgt atgtgcaggg cggcgagtag atg gtt gac Asp cgt Arg att Ile at t Ile acg Thr ctg Le u ca g Gin acc aag Lys gtg Val1 t cg Ser cta Leu qaa Glu ct C Leu ttt Phe gog aaa Lys att Ile tgg T rp gcg Ala 60 gt c Val1 ggt Gl y aac Asn gtg got Ala gtg Val1 tcg Ser att Ile gtg Val1 gc Ala ccg Pro ggt ggc Gly ctg Leu att Ile tta Le u tgg T rp got Ala ctg Leu 110 got Cgg Arg 15 ttt Phe ctg Le u 9CC Ala caa Gin ttq Leu 95 gog Al a qct gtg Val gt c Val1 qtc Val1 tcc Se r atc Ile ggc Gly ga a Glu gcg Met 1 ct Pro go9 Al a ggc Gly ggt Gly ogc Arq gtg ValI ccg Pro qtg Val1 qgt Gi y ct 9 Leu caa Gin ccg Pro atg Met gcc Ala tog Se r atc gtg aag gag Val Lys Glu got ata got Ala Ile Ala qgc gog atc Gly Ala Ile tao acc atc Tyr Thr Ile acc ggt gcg Thr Gly Ala ccg cgc ato Pro Arg Ile ggc gcg Ctg Gly Ala Leu 100 ato ato ggo Ile Ile Gly 115 gtg ttt aao 115 163 211 259 307 355 403 451 499 Val Thr Ser Gly Ala Gly Val Giy 120 125 ctg aca ttt ttg ggc aca tcc acc Leu Thr Phe Leu Giy Thr Ser Thr 135 140 gcg gtg atc acc acg att ttg qta. Ala Vai Ile Thr Thr Ile Leu Val 150 155 cgt gtq caa gtg atc aac ctg atc Arg Val Gin Val Ile Asn Leu Ile 170 gta tcc ggc gcg ctg acc tca gtt Vai Ser Gly Ala Leu Thr Ser Val 185 ctc ccg cga aga aat att ttc tgc Leu Pro Arg Arg Asn Ile Phe Cys 200 205 ggc gca cgt caa cgt Gly Ala Arg Gin Arg 215 <210> 566 <211> 218 <212> PRT <213> Corynebacterium glutamicum <400> 566 Met Val Vai Lys Glu Vai Asp Vai 1 5 Pro Gly Ala Ile Ala Lys Arg Arq Ala Leu Giy Ala Ile Vai Ile Ala 40 Gly Gin Tyr Thr Ile Pro Ile Arg 55 Giy Pro Thr Gly Ala Gin Thr Met 70 Arg Met Pro Arg Ile Val Leu Gly Val Ala Gly Ala Leu Leu Gin Ala 100 Pro Ser Ile Ile Gly Val Thr Ser 115 120 Val Ile Val Phe Asn Leu Thr Phe 130 135 Al a gtc Val1 tat Tyr :tq Leu ctt Leu 190 aga Arg Ala gca Ala cag Gin aca Thr 175 gat Asp tgg Trp Ala gtc Vali ctg Leu 160 99C Gly cta Leu gtt Val1 Val 9gc Gi y 145 gcc Al a ata Ile cat His cct Pro Phe att Ile cgt Arg aat Asn 180 ga c Asp t cg Ser 547 595 643 691 739 Glu Lys Gin Lys Ala Gly 10 Thr Val Arg Ile Val Leu 25 Ala Ser Leu Trp Ser Ile A~sp Leu Pro Ala Ile Leu Alia Giu Gin Val Val Trp 75 Leu Leu Vai Gly Ala Ala 90 Val Phe Ser Asn Pro Leu 105 110 Gly Ala Gly Vai Gly Ala 125 Leu Gly Thr Ser Thr Val Arg Val Phe Val Leu Val Ala Ser Gin Ile Leu Gly Ala Glu Ala Ala Ala Val Gly Ala Phe Ile Thr Ala 145 150 Val Ile Thr Thr Ile 155 Leu Val Tyr Gin Leu 160 Ala Arg Ser Arg Gly 165 Arg Val Gin Vai Asn Leu Ile Leu Thr Gly 175 Ile Ala Ile His Arg Ala 195 Pro His Gly 210 Ala Val Ser Gly Leu Thr Ser Val Leu Asp Leu 190 Arg Trp Val Asp Giu Leu Pro Arg 200 Arg Asn Ile Phe Ser His Gly Arg Gin Arg <210> 567 '211> 357 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (334) <223> RXN02979 <400> 567 ctaggtcaag gaacttcact cggctagtcc ttagactcaa atgtgttcag acaaacactg gcaccgtaag gcacgaaagt taccgaaaqg actggttccc atg acc gcc cca aac Met Thr Ala Pro Asn act ctc aag caa Thr Leu Lys Gin aca Thr act ctt cgc tct Thr Leu Arg Ser gag ttc tct tgc Giu Phe Ser Cys cca tcc Pro Ser tgt gtc tcc Cys Val Ser aat gca gag Asn Ala Giu att gaa aac aaa Ile Giu Asn Lys ttg Leu aat gga ttg gat Asn Gly Leu Asp ggc gtc qac Giy Val Asp gat cac gac Asp His Asp 211 259 gtg aag ttc tcc Vai Lys Phe Ser tcc Ser 45 gga aga atc ctt Gly Arg Ile Leu gtt Val1 ccc agc Pro Ser aag gtc tct atc Lys Val Ser Ile gat cta gtc gct Asp Leu Vai Ala gtc gca gag gtt Val Ala Giu Val ggc tac acc gca aag cca tca gca atc Giy Tyr Thr Ala Lys Pro Ser Ala Ile tta (210> 568 <211> 78 <212> PRT <213> Corynebacterium giutamicum taaaactctc agttagacca <400> 568 Met Thr Ala Pro Asn Thr Leu Lys Gin Thr Thr 1 5 10 Phe Ser Cys Pro Ser Cys Val Ser Lys Ile Glu Leu Asp Gly Val Asp Asn Ala Glu Val Lys Phe 40 Leu Val Asp His Asp Pro Ser Lys Val Ser Ile Ala Val Ala Glu Val Gly Tyr Thr Ala Lys Pro 70 (210> 569 (211> 357 <212> DNA (213> Corynebacterium qlutamicum <220> <221> CDS <222> (101)..(334) <223> RXN02987 (400> 569 gttgtttgat ccaggtcaag gaattaaecc ggaaaggacc acaggaacat gacgataaaa gatgaaagga cctggttacg Arg Lys Ser Asp Ala Asp Glu Asn Gly Arg Ile Val Ala gtatctttaa aggtqcaagc atq ace gcc cec gcc acg ctg aag aac acc ace ttg egc tct Thr Leu Lys Asn Thr Thr Leu Arg Ser tgt gtc gcc aag atc gaa aae aag etg Cys Val Ala Lys Ile Glu Asn Lys Leu 30 aat qcg gag qtg aag ttc tee tee gga Asn Ala Glu Val Lys Phe Ser Ser Gly 45 cca eag aag gtc tee gta egt gac ctg Pro Gln Lys Val Ser Val Arg Asp Leu 60 ggt tac ace gec aag cqg tcg geg ate Gly Tyr Thr Ala Lys Pro Ser Ala Ile aag (210> 570 (211> 78 <212> PRT (213> Corynebacterium glutamicum Met Thr Ala Pro Ala 1 gat gag ttc ace tgt eeg age Asp Glu Phe Thr Cys Pro Ser 15 aat ggt ttg qac gge gtg gag Asn Gly Leu Asp Gly Val Glu ege ate ctg ate ace cac qac Arg Ile Leu Ile Thr His Asp gte ace geg qta gee gag gte Val Thr Ala Val Ala Glu Val tgacgeactc cegacceac 115 163 211 259 3 07 354 <400> 570 Met Thr Ala Pro Ala Thr Leu Lys Asn Thr Thr 1 5 10 Phe Thr Cys Pro Ser Cys Val Ala Lys Ile Giu 25 Leu Asp Gly Val Glu Asn Ala Giu Val Lys Phe 40 Leu Ilie Thr His Asp Pro Gin Lys Val'Ser Val Ala Val Ala Giu Val Gly Tyr Thr Ala Lys Pro 70 <210> 571 <211> 1041 <212> DNA <213> Corynebacteriun qiutamicum <220> <221> CDS <222>' (101)..(1018) <223> RXN03084 <400> 571 ccacccccac gtctaagttt tcccctattt acacacacct Arg L ys Ser Asp Ala Ser Asp Glu Leu Asn Gly Gly Arg Ile Leu Val Thr Ile gaccgaagct gtaaggtttg cctaatcttt ttcaatctaa agtcaggata ttcacagccc atg tca tct cgc aga Met Ser Ser Arg aaa Lys act Thr act Thr Cct Pro gcc Ala ggt Gly gtt Val1 t cc Ser tgt Cys ga a Glu cgc Arg gga Gly ct Pro gag Glu gca Al a tcc Ser aca Thr gt t Val1 acc Thr tat T yr aat Asn ct g Le u aqc Ser gac Asp gt c Val1 cca Pro 75 ct c Le u atc Ile gtg Val1 gaa Giu cac His 45 gag Glu ggt Gly gt c Val1 gcg Al a ct t Leu qa g Glu gga Gi y cca Pro gca Ala ga t Asp atc Ile ctc Leu 15 gaa Glu aca Thr ott Leu gct Ala gga Gly 95 got Ala gca Al a g ca Ala aco Thr gag Glu gtc Val1 80 atc Ile gct Ala 1 gca Ala tcc Se r ga a Giu cta Le u gcc Al a gag Glu ot c Le u gca Al a acc Thr gtt Val1 gao Asp aac As n ct Pro gag Glu cta Leu agc Ser ccc Pro acc Thr aac As n gtc Val1 ccc Pro cct Pro t ct Ser gaa Glu gca Ala gtc Val1 Gly 100 gac Asp Arg ctt Le u qgg Ala aat Asn atc Ile act Thr acc Thr ct g Le u 115 163 211 259 307 355 403 451 11 atc ctg ggc Ile Leu Gly 120 acc gat tcc cc Thr Asp Ser Arg cac His 125 gcc gaa atc tac Ala Giu Ile Tyr cgc Ctc gaa Arg Leu Giu tcc atc Ser Ile 135 gcc cca acc gtg Ala Pro Thr Val atg aca acc cat Met Thr Thr His gat ccg tgg aaa Asp Pro Trp Lys aat gtc gtc ttc Asn Val Val Phe at c Ile 155 ggc gat gca, ttg Giy Asp Ala Leu ggC Gly 160 aag aag cag gaa Lys Lys Gin Giu gag gat ctc atc Giu Asp Leu Ile caa Gin 170 ggo ttt aat gac Giy Phe Asn Asp tgc gaa gag atc Cys Giu Giu Ile aag tcc Lys Ser 180 gag cat gat Giu His Asp gag caa acc Glu Gin Thr 200 gaa ggt aag acc Giu Giy Lys Thr aao atg att cgt Asn Met Ile Arg coo cgc gac Pro Arg Asp 195 ggo agc tct Gly Ser Ser atg agc cta tac Met Ser Leu Tyr ggc Gly 205 ccg acc tca ttt Pro Thr Ser Phe ttq gag Leu Giu 215 tgc qca gga oto Cys Ala Giy Leu acc Thr 220 att cct gat cag Ile Pro Asp Gin tgg aag gat gac Trp Lys Asp Asp cag gcc gac atc Gln Ala Asp Ile oct gag aac ttc Pro Glu Asri Phe ctc gcc acc gcc Leu Ala Thr Ala g ac Asp 245 tac gtc ttt gtc Tyr Val Phe Val goa act gat gtc Ala Thr Asp Vai aco Thr 255 gat gaa aat gag Asp Giu Asn Giu oto ccc Leu Pro 260 gaa gta atc Giu Vai Ile gat aco ago Asp Thr Ser 280 oga Arg 265 gaa aac cgc gaa Giu Asn Arg Glu cag Gin 270 ttc cca tca oto Phe Pro Ser Leu tao tgg gta tot Tyr Trp Val Ser ggC Gly 285 gtc ggt oca ott Vai Gly Pro Leu acc ctt gtc Thr Leu Vai 275 ggo ago aaa Giy Ser Lys taatgtccac 931 979 1028 gto ttg Vai Leu 295 gaa gao ato gat Giu Asp Ile Asp ttc oto gao gca Phe Leu Asp Ala cag caa Gin Gin 305 agototococ gat <210> 572 <211> 306 <212> PRT <213> Corynebacterium glutamicun <400> 572 Met Ser Ser Arg Arq Lys Leu Ser Ser Ala Leu Ile Val Leu Leu Ala 1 5 10 1041 Ala Ala Leu Pro Leu Thr Ala Cys Ser Ser Ser Ser Glu Glu Glu Ala 25 Ser Thr Ser Ser Ala Thr Arg Glu Phe Thr Asp Ala His Gly Thr Thr 40 Glu Val Pro Glu Asn Pro Gin Arg Val Val Val Leu Glu Pro Leu Glu 55 Leu Asp Thr Ala Ile Ala Leu Gly Ile Thr Pro Val Gly Ala Ala Val 70 75 Ala Asn Asn Val Thr Gly Ile Pro Ala Tyr Leu Gly Val Asp Gly Ile 90 Glu Pro Val Gly Thr Val Ser Glu Pro Asn Ile Glu Ala Ile Ala Ala 100 105 110 Leu Glu Pro Asp Leu Ile Leu Gly Thr Asp Ser Arg His Ala Glu Ile 115 120 125 Tyr Asp Arg Leu Glu Ser Ile Ala Pro Thr Val Phe Met Thr Thr His 130 135 140 Val Asp Pro Trp Lys Asp Asn Val Val Phe Ile Gly Asp Ala Leu Gly 145 150 155 160 Lys Lys Gin Glu Ser Glu Asp Leu Ile Gin Gly Phe Asn Asp Lys Cys 165 170 175 Glu Glu Ile Lys Ser Glu His Asp Val Glu Gly Lys Thr Val Asn Met 180 185 190 Ile Arg Pro Arg Asp Glu Gin Thr Met Ser Leu Tyr Gly Pro Thr Ser 195 200 205 Phe Ala Gly Ser Ser Leu Glu Cys Ala Gly Leu Thr Ile Pro Asp Gin 210 215 220 Glu Trp Lys Asp Asp Leu Gln Ala Asp Ile Ala Pro Glu Asn Phe Met 225 230 235 240 Leu Ala Thr Ala Asp Tyr Val Phe Val Thr Ala Thr Asp Val Thr Asp 245 250 255 Glu Asn Glu Leu Pro Glu Val Ile Arg Glu Asn Arg Glu Gin Phe Pro 260 265 270 Ser Leu Thr Leu Val Asp Thr Ser Tyr Trp Val Ser Gly Val Gly Pro 275 280 285 Leu Gly Gly Ser Lys Val Leu Glu Asp Ile Asp Ala Phe Leu Asp Ala 290 295 300 Gin Gin 305 <210> 573 <211> 440 <212> DNA <213> Corynebacterium giutamioum <220> <221> CDS <222> (417) <223> RXN03183 <400> 573 qaa gcc gaa goa acc Giu Ala Giu Ala Thr 1 5 gca ggc aaa ttc Ala Gly Lys Phe gta cag ccc ctc Val Gin Pro Leu gta ggt Val Gly aaa gao ggc Lys Asp Gly aac gto aac Asn Val Asn gtc Val1 ggc gta toc acc Gly Val Ser Thr ct t Le u 25 ggt ggc tac aac Gly Gly Tyr Asn aao ggc atc Asn Gly Ile atc gaa ttc Ile Glu Phe tcc gaa aao aag Ser Giu Asn Lys aco goc ogc gac Thr Ala Arg Asp atc atc Ile Ile aao gaa gag aac Asn Giu Giu Asn oaa Gin 55 aoc tgg ttc gcg Thr Trp Phe Ala gac Asp aao tcc ttc coa Asn Ser Phe Pro cca Pro gtt otg gca too Val Leu Ala Ser ato Ilie 70 tao gat gat gag Tyr Asp Asp Giu ctt gtt gag cag Leu Val Giu Gin tac Tyr coa tao ctg cca Pro Tyr Leu Pro ctg aag gaa tc Leu Lys Glu Ser gaa aac goa goa Glu Asn Ala Ala cca ogo Pro Arg cca gtg tct Pro Val Ser qoc tao gca Ala Tyr Ala 115 ct Pro 100 tto tac cca gc Phe Tyr Pro Ala too aaq gca ato Ser Lys Ala Ile cag gac aac Gin Asp Asn 110 gca acc aco Ala Thr Thr gog ctt aac ggo Ala Leu Asn Gly aac As n 120 gto gac gtt gao Val Asp Val Asp cag Gin 125 gat atg Asp Met 130 t to aag gca gcg ato Lys Aia Ala Ile gaa Giu 135 aao got tco ago Asn Ala Ser Ser tagttoggta atttagttoa 437 440 <210> 574 (211> 139 <212> PRT <213> Corynebaoterium glutarnioum <400> 574 Glu Ala Glu Ala Thr Ala Gly Lys Phe 1 5 Lys Asp Gly Val Gly Val Ser Thr Leu 25 Val Gin Pro Leu Vai Gly Gly Gly Tyr Asn Asn Gly Ile Asn Val Asn Ser Giu Asn Lys Ala Thr Ala Arg Asp Phe Ile Giu Phe Ile Ile Asn Glu Glu Asn Gin Thr Trp Phe Ala Asp 55 Pro Val Leu Ala Ser Ile Tyr Asp Asp Glu Ser Leu 70 Pro Tyr Leu Pro Ala Leu Lys Glu Ser Leu Glu Asn 90 Pro Vai Ser Pro Phe Tyr Pro Ala Ile Ser Lys Ala 100 105 Ala Tyr Ala Ala Leu Asn Gly Asn Val Asp Vai Asp 115 120 Asp Met Lys Ala Ala Ile Giu Asn Ala Ser Ser 130 135 <210> 575 <211> 1077 <212> DNA 213> Corynebacterium giutamicum <220> <221> CDS (222> (101)..(1054) <223> RXN01139 <400> 575 aceaccgtgg eaggcttttt eagtggeaag aagattaatt etc taagctttea ataaggggag aagtgtgctt agctggggte atg Ser Glu Ala Gin 110 Ala Phe Gin Pro Asp Thr cacccct tcattttcaa cag Gin gac Asp gcg Ala ggc Gly ctq Leu ggc Gly cag Gin gga Gly gtc Val ctt Leu tee Ser cgt Arg cgc Arg etc Leu atc Ile att Ile gac Asp cgg Arg agt Ser gga Gly att Ile tee Ser tee Ser gca Ala tat Tyr cac His ttc Phe gga Gly act Thr ege Arg aat Asn qct Ala 30 ate Ile gca Ala ate Ile egt Arg cCC Pro 15 cCC Pro ate Ile etg Leu att Ile gcg Ala 95 gat Asp age Ser tte Phe etg Leu gcg Ala 80 ace Thr Met 1 ggc Gly tee Ser eta Leu get Ala get Ala tac Tyr gaa Glu cac His etc Leu geg Ala gac Asp gte Val gga Gly age Ser gac Asp aag Lys gaa Glu gee Ala gee Ala tac Tyr cac His cac His get Ala eta Leu atg Met atg Met aag Lys 100 gat Asp age Ser ctt Leu atc Ile cae His etc Leu cgt Arg 115 163 211 259 307 355 403 gcg gaa, gto Ala Giu Val tot gtg tgg Ser Val Trp 120 ttg Len 105 gca gcg atg gtt Ala Ala Met Val aac As n 110 gcc aoc gtt gtt Ala Thr Vai Vai aca gca ctg Thr Ala Len 115 aag gac otg Lys Asp Len atc gtc gtt gag Ile Val Val Gin atc atg ogt ctg Ile Met Arq Len ggc Gly 130 gaa aic Gi Ilie 135 cag 8CC aac ctg Gin Thr Asn Leu atg Met 140 ctc atc gtc gcg Leu Ile. Val Ala gtc Val1 145 att ggt ttt gtc Ile Gly Phe Val acc Thr 150 aac gga att tcc Asn Giy Ile Ser ctg gtg ttg atg Leu Val Leu Met cac caa gat ggc His Gin Asp Giy aat Asn 165 ato aat atg cgt Ile Asn Met Arq gca ttc ctt cac Ala Phe Len His ctc agt gac atg Len Ser Asp Met otg ggt Len Gly 180 too gtt gc Ser Vai Ala atg ccg gcc Met Pro Ala 200 att att gcg ggo Ile Ilie Ala Gly ctg Len 190 gtg att ogo tao Val Ile Arg Tyr acg gga tgg Thr Gly Trp 195 att att att Ile Ile Ile 691 739 gat acc att got Asp Thr Ilie Ala att gcg att gct Ile Ala Ile Ala cot cqo Pro Arg 215 gca ttc agc ctc Ala Phe Ser*Leu aag gaa gct otc Lys Gin Ala Leu atc ttg ttg gag Ile Len Len Glu gtt cot aca ggt Val Pro Thr Gly gog Al a 235 gag cot goa gag Gin Pro Ala Gin gac gca gco ott Asp Ala Ala Len cgt Arg 245 aaa gtc 008 gqt Lys Val Pro Gly gtc Val1 250 ago qat gtg oat Ser Asp Val His gat Asp 255 ott cac att tgg Len His Ile Trp ago att Ser Ilie 260 gao ggo aag Asp Gly Lys aca aat cag Thr Asn Gin 280 ato otg gcc acg Ile Leu Ala Thr gt g Val1 270 oat ttg qtg gtg His Len Val Val gat tog tot Asp Ser Ser 275 gaa gog gaa Gin Ala Gin 931 979 ctg cat agt tgt Len His Ser Cys ggo Gly 285 gtg ttg gat cgg Val Len Asp Arg ota too Len Ser 295 aaa ott ggg ato Lys Len Gly Ilie oac toa aca att His Ser Thr Ile otq gaa ago goa Leu Gin Ser Ala 1027 gat Asp 310 ggq cac agt gat oat His Ser Asp His gaa Gin 315 agt gtg tgo Ser Val Cys tgatatagag tatgtccoat 1074 1077 <210> 576 <211> 318 <212> PRT <213> Corynebacterium glutamicum <400> 576 Met Glu Ser His Asp Leu Gin Gin Arg Ser Tyr Ala His Asn Pro Asp 1 5 10 Gly His Asp His Ser His Asp Gly Leu Gly His Ser His Ala Pro Ser 25 Ser Leu Lys Ala Leu Phe Ala Val Ile Ile Phe Thr Ser Ile Ile Phe 40 Leu Ala Glu Leu Ile Ala Gly Leu Ile Ser Gly Ser Leu Ala Leu Leu 55 Ala Asp Ala Met His Met Leu Ser Asp Ser Thr Gly Leu Ile lie Ala 70 75 Ala Val Ala Met Leu Ile Gly Arg Arg Ala Arg Thr Ser Arg Ala Thr 90 Tyr Gly Tyr Lys Arg Ala Glu Val Leu Ala Ala Met Val Asn Ala Thr 100 105 110 Val Val Thr Ala Leu Ser Val Trp Ile Val Val Glu Ala Ile Met Arg 115 120 125 Leu Gly Lys Asp Leu Glu Ile Gin Thr Asn Leu Met Leu Ile Val Ala 130 135 140 Val Ile Gly Phe Val Thr Asn Gly Ile Ser Ala Leu Val Leu Met Arg 145 150 155 160 His Gin Asp Gly Asn Ile Asn Met Arg Gly Ala Phe Leu His Val Leu 165 170 175 Ser Asp Met Leu Gly Ser Val Ala Val Ile Ile Ala Gly Leu Val Ile 180 185 190 Arg Tyr Thr Gly Trp Met Pro Ala Asp Thr Ile Ala Ser Ile Ala Ile 195 200 205 Ala Ala Ile Ile Ile Pro Arg Ala Phe Ser Leu Leu Lys Glu Ala Leu 210 215 220 Asn Ile Leu Leu Glu Arg Val Pro Thr Gly Ala Glu Pro Ala Glu Val 225 230 235 240 Asp Ala Ala Leu Arg Lys Val Pro Gly Val Ser Asp Val His Asp Leu 245 250 255 His Ile Trp Ser Ile Asp Gly Lys Glu Ile Leu Ala Thr-Val His Leu 260 265 270 Val Val Asp Ser Ser Thr Asn Gin Leu His Ser Cys Gly Val Leu Asp 275 280 285 Arg Ala Glu Ala Glu Leu Ser Lys Leu Gly Ile Leu His Ser Thr Ile 290 295 300 Gin Leu Glu Ser Ala Asp His Ser Asp His Glu Ser Val Cys 305 310 315 <210> <211> <2 12> <213> <220> <221> <222> <223> 577 2733 DNA Corynebacterium CDS (101) (2710) RXN 00378 glutamicum <400> 577 accgtgagcc ttatactgtg aggacattaa aagtgacacc tctttttcta tcttttacaa cccaagaagg tttatcgtga gcacaccqga ttcttcctcg gt g ValI 1 gac aag gcc Asp Lys Ala aac act gct atc Asn Thr Ala Ile qac gcc aaa aca Asp Aia Lys Thr gcg ctc aag gca Ala Leu Lys Ala ggt gtt Gly Val gga ttg aac Gly Leu Asn agc att aag Ser Ile Lys gcc acc gcc tca Ala Thr Ala Ser qa a Giu gaa, gag gaa gat Glu Giu Giu Asp tta agc tca Leu Ser Ser agc aat gca Ser Asn Ala 211 259 gtt tct ttg gcc Val Ser Leu Ala gag ctc gag ggg Glu Leu Glu Gly tta Leu cca tcg Pro Ser ttg atg gtg gtg Leu Met Val Val aaa gcc cta gag Lys Ala Leu Glu atc ccc ggt gta Ile Pro Gly Val t cc Ser gcg gat ctg att Ala Asp Leu Ile tac Tyr 75 cct tca caa act Pro Ser Gin Thr gca Ala 80 tgg att aca gca Trp Ile Thr Ala act Thr gat cgg gta cat Asp Arg Val His ccc Pro gaa acc ctc att Giu Thr Leu Ile gtg ttt gag cag Val Phe Glu Gin ttc ggc ?he Gly 100 atc aaa gca Ile Lys Ala ctc agc gcg Leu Ser Ala 120 ctt tct aat tca Leu Ser Asn Ser ctg ctg cgc agg Leu Leu Arg Arg cat caa cag His Gin Gin 115 tac cgc tcc Tyr Arg Ser 451 499 gaa. gta aat agg Giu Val Asn Arg ga a Giu 125 gca cgc ctt gat Ala Arg Leu Asp cgt Arg 130 cga atg Arg Met 135 gat gcc aag cga Asp Ala Lys Arg atc Ile 140 tcg cct cgt gtg Ser Pro Arg Val cga Arg 145 agg cat aac cga Arg His Asn Arg 547 595 caa Gin 150 gaa atg gta cat Glu Met Val His gta cgc gct cgt Val Arg Ala Arg agt ggt tgg att Ser Gly Trp Ile cgc agg aat cac Arg Arg Asn His acc Thr 170 acc tcg cag cat Thr Ser Gin His gac cca atg teg Asp Pro Met Ser gge gat Gly Asp 180 gtg ctg ttc Val Leu Phe tcg ttg ceg Ser Leu Pro 200 gcc ege gca etg Ala Arg Ala Leu aca cct aag egt Thr Pro Lys Arg ttg tgg gtg Leu Trp Val 195 aat. cct tcg Asn Pro Ser ttt gcg ctc atc Phe Ala Leu Ile gt a Val1 205 ttg gcg tta tcg Leu Ala Leu Ser tgg caq Trp Gin 215 ttt gat tat tgg Phe Asp Tyr Trp tgg ttg toc gct. Trp Leu Ser Ala ttg got att cct. Leu Ala Ile Pro gtg gtg gtg tgg ggt gCC tgg ccg ttt cac cgc gct gca gca ggc ggt Val Val Val Trp Gly Ala Trp Pro Phe His Arg Ala Ala Ala Gly Gly 230 235 240 245 att ogt cga gga Ile Arg Arg Gly att Ile 250 tee gct ctt gat Ser Ala Leu Asp gcg Ala 255 ace agc tca ato Thr Ser Ser Ile get att Ala Ile 260 got got gca Ala Ala Ala gga ggt aaa Gly Gly Lys 280 gcg tgg tct atc Ala Trp Ser Ile atg etg ttg ttt Met Leu Leu Phe gaa acc cca Glu Thr Pro 275 ttt gac oac Phe Asp His tco tgg cgg tea Ser Trp Arg Ser tat Tyr 285 cog too tgg tto Pro Ser Trp Phe got Ala 290 ggec aog Gly Thr 295 ttg ace oaa aae Leu Thr Gin Asn att tat ttt gat Ile Tyr Phe Asp gtg Val1 305 goo tge gga ate Ala Cys Gly Ile gtg ttg ott ott Val Leu Leu Leu gga egg otg etg Gly Arg Leu Leu aca Thr 320 agg egt cga age Arg Arg Arg Ser 1027 1075 1123 tee agt ttg tta Ser Ser Leu Leu gaa ott. ggt ego Giu Leu Gly Arg caa ate gat eea Gin Ile Asp Pro eag ego Gin Arg 340 att gtc aot Ile Val Thr otg aao att Leu Asn Ile 360 gtg Val1 345 gtg egt aaa oae Vai Arg Lys His ega Arg 350 ttg aag ego gta Leu Lys Arg Val gtc cag gaa Val Gin Giu 355 gtg aaa gtt Val Lys Val 1171 1219 ooa gtg cag gaa Pro Val Gin Glu cgt gto aat gao Arg Val Asn Asp cea cot Pro Pro 375 aat ace aeg atc Asn Thr Thr Ile gtg gat gge aet Val Asp Gly Thr ate ggt gge ggt Ile Gly Giy Gly 1267 1315 t cg Se r 390 egg ate gea got Arg Ile Ala Ala age Ser 395 ate ate atg gga Ile Ile Met Gly gao oag egt Asp Gin Arg gat gta Asp Val 405 aaa gta aat qac Lys Val Asn Asp gjtt ttc gCC ggc Val Phe Ala Gly agc Se r 415 ctc aac ctc gaa Leu Asn Leu Glu tcc gaa Ser Giu 420 1363 atc aag gtt Ile Lys Val gta cat agg Val His Arg 440 cgt Arg 425 gtt att cgc act Val Ile Arg Thr cac cgc acc cgc His Arg Thr Arg atc gcc gcg Ile Ala Ala 435 cgc cac aat Arg His Asn 1411 1459 tgg gtt aaa gaa Trp Val Lys Glu acg ttg aag gaa Thr Leu Lys Glu aac Asn 450 agg gca Arg Ala 455 qcg atc cgt tcg Ala Ilie Arg Ser gcc Ala 460 qqt aac ctt gtg Gly Asn Leu Val atc acg ttc acc Ile Thr Phe Thr gct gtg gtg gac Ala Val Val Asp tgt ctg tgg gca Cys Leu Trp Ala atc tct gga aac Ile Ser Gly Asn 1507 1555 1603 aac gct gca ttt Asn Ala Ala Phe acc Thr 490 act acc ttg gct Thr Thr Leu Ala qt c Val1 495 ctt gcg tgc gtg Leu Ala Cys Val gct ccg Ala Pro 500 gtq gcc tta Val Ala Leu gct gca gca Ala Ala Ala 520 ttq tct gct cca Leu Ser Ala Pro qcc acq aqq aat Ala Thr Arg Asn tcc atc qaa Ser Ile Glu 515 att ttc cga Ile Phe Arg cga cac ggt att Arg His Gly Ile gtc cgc tct gqt Val Arg Ser Gly gtt ctc Val Leu 535 gat gat gtg gat Asp Asp Val Asp gcc gta ttt aat Ala Val Phe Asn cgt Arg 545 gtg ggc aca cta Val Gly Thr Leu 1651 1699 1747 1795 1843 acc Thr 550 gat ggc gaa atg Asp Giy Glu Met aca Thr 555 gtg gaa acc qtc Val Giu Thr Val aca Thr 560 gca gac aaa. ggc Ala Asp Lys Giy gac cca gaa cta Asp Pro Glu Leu ctq cgt gtc gcc Leu Arg Val Ala gcg ttg gcc atg Ala Leu Ala Met gaa tcc Glu Ser 580 cac cac gcg His His Ala gat acc ggc Asp Thr Gly 600 att Ile 585 tcc aaa gca ctg Ser Lys Ala Leu aaa qca tcc cgt Lys Ala Ser Arg gaa gct cgt Glu Ala Arg 595 gaa gta ggc Glu Val Gly 1891 1939 gcc qgt ggt gaa Ala Gly Gly Giu gtc cca cac tgg Val Pro His Trp att Ile 610 aac gtg Asn Val 615 gaa atc acc gaa Glu Ile Thr Glu gcc Ala 620 ggc tca ttc caa Gly Ser Phe Gin acc atc gag ctg Thr Ile Giu Leu 1987 2035 ctg atc aaa cca Leu Ile Lys Pro ggc gaa aaa atc Gly Glu Lys Ile cgc acc aca gaa Arg Thr Thr Glu gca Al a 645 ctc ctg tgg cga cca cga tcc atg aca gaa gtc cgt gag cac tta agc 28 2083 Leu Leu Trp ArgPro Arg ser Met Thr Giu Vai Arg Giu His Leu Ser 650 gca gca gca acc Ala Ala Ala Thr 655 ggt ggc gca cca Gly Gly Ala Pro ccc cqa cta Pro Arg Leu cga tgg aaa Arq Trp Lys 680 gtq Val1 665 660 ctg atc gtg *Leu Ile Val 675 gac cac gtg Asp His Val 2131 2179 ggo aaa gac ogc Gly Lys Asp Arg gtt atc act ota Val Ile Thr Leu aqa tca Arg Ser 695 gat tcc tcc gat Asp Ser Ser Asp gcg Ala 700 att att gcg att Ile Ile Ala Ile gaa Giu 705 qaa caa ggc atc Giu Gin Gly Ile acc atg atg ctt Thr Met Met Leu cgt gat act tac Arg Asp Thr Tyr gtg gca cgt cga Val Ala Arg Arg gca qac ago tta Ala Asp Ser Leu atc acc cac gtc Ile Thr His Val ttg Leu 735 gcc ggc atc gcg Ala Giy Ile Ala cog ggc Pro Gly 740 2227 2275 2323 2371 2419 aag aaa gcc Lys Lys Ala gcg atg atc Ala Met Ile 760 cag Gin 745 gtc gtc cgt gca Val Val Arg Ala cac acc ogc gga His Thr Arg Gly tcc act gtc Ser Thr Vai 755 gtc gct gac Val Ala Asp ggc gat gaa tca Gly Asp Giu Ser atg gac tqt ttg Met Asp Cys Leu gtg ggt Val Gly 775 gta ctg atg ggc Val Leu Met Gly gtC Val 780 gat Cgt CCC tca Asp Arg Pro Ser gat Asp 785 ctg cgt gat gat Leu Arg Asp Asp gat gac ccg gca Asp Asp Pro Ala gac gtt gtg gto Asp Val Val Val atg Met 800 cgc gaa gag gtc Arq Giu Glu Val 2467 2515 2563 ago gtg ccg acg Ser Val Pro Thr ttt aaa ctg gct Phe Lys Leu Ala cg a Arg 815 cgc tac 9cc aag Arg Tyr Ala Lys ttg gto Leu Val 820 aat ggc aat Asn Gly Asn ctt gca gtg Leu Ala Val 840 att Ile 825 gct ctg gcc tgg Ala Leu Ala Trp atc Ile 830 tat aac ggt gtt Tyr Asn Giy Val gcc atg gtg Ala Met Val 835 gtg got atg Val Ala Met 2611 2659 tct ggc ttg ctg Ser Gly Leu Leu oca atg gct gcg Pro Met Ala Ala ctg gcg Leu Ala 855 tot tcg ctg ott Ser Ser Leu Leu gaa tgg cgc tog Glu Trp Arg Ser agg gcg ogo aaq Arg Ala Arg Lys 2707 2733 tao taacoagcaa ttcocaagoo oaa T yr 870 <210> 578 ,4211> 870 ,e212> PRT <213> Corynebacterium giutamicun <400> 578 Val Asp Lys Ala Val Asn Thr Ala Ile Ser Asp Ala Lys Thr Ala Ala 1 5 10 Leu Lys Ala Gly Val Gly Leu Asn Arg Ala Thr Ala Ser Glu Giu Glu 25 Giu Asp Leu Ser Ser Ser Ile Lys Val Ser Leu Ala Phe Giu Leu Glu 40 Gly Leu Ser Asn. Ala.Pro Ser Leu Met Val Val Glu Lys Ala Leu Glu 55 Lys Ile Pro Gly Val Ser Ala Asp Leu Ile Tyr Pro Ser Gin Thr Ala 70 75 Trp Ile Thr Ala Thr Asp Arg Val Hi .s Pro Glu Thr Leu Ile Glu Val 90 Phe Glu Gin Phe Gly Ile Lys Ala His Leu Ser Asn Ser Ser Leu Leu 100 105 110 Arg Arg- His Gin Gin Leu Ser Ala Giu Val Asn Arg Giu Ala Arg Leu 115 120 125 Asp Arg Tyr Arg Ser Arq Met Asp Ala Lys Arg Ile Ser Pro Arg Val 130 135 140 Arg Arg His Asn Arg Gin Giu Met Val His Ala Val Arg Ala Arg Glu 145 150 .155 160 Ser Gly Trp Ile Lys Arg'Arg As n His Thr Thr~v S er *Gin His Giu -Asp 165 170 175 Pro Met Ser Gly Asp Val Leu Phe Thr Ala Arq Ala Leu Ile Thr Pro 180 185 190 Lys Arg Leu Trp Val Ser Leu Pro Phe Ala Leu Ile Val Leu Ala Leu 195 200 205 Ser Leu Asn Pro Ser Trp Gin Phe Asp Tyr Trp Gin Trp Leu Ser Ala 210 215 220 Val Leu Ala Ile Pro Val Val Val Trp Gly Ala Trp Pro Phe His Arg 225 230 235 240 Ala Ala Ala Gly Gly Ile Arg Arg Gly Ile Ser Ala Leu Asp Ala Thr 245 250 255 Ser Ser Ile Ala 11i'e Ala Ala Ala Tyr Ala Trp Ser Ile Ala Met Leu 260 265 270 Leu Phe Giu Thr Pro Gly Giy Lys Ser Trp Arg Ser Tyr Pro Ser Tr~p 275 280 285 Phe Ala Phe Asp His Gly Thr Leu Thr Gin Asn Glu Ile Tyr Phe Asp 290 295 300 Val 305 Arg Ile Arg Asp Val 385 Asp Asn Thr Glu Pro 465 Ile Ala Arg Gly Arg 545 Ala Leu Ser Ala Arg Asp Val Asp 370 Ile Gin Leu Arg Asn 450 Ile Ser Cys Asn Glu 530 Val Asp Ala Arg Cys Arg Pro Val 355 Val Gly Arg Glu Ile 435 Arg Thr Gly Val Ser 515 Ile Gly Lys Met Glu 595 Gly Ser Gin 340 Gin Lys Gly Asp Ser 420 Ala His Phe Asn Ala 500 Ile Phe Thr Gly Glu 580 Ala Ile Gln 325 Arg Glu Val Gly Val 405 Glu Ala Asn Thr Ile 485 Pro Glu Arg Leu Glu 565 Ser Arg Thr 310 Ser Ile Leu Pro Ser 390 Lys Ile Val Arg Leu 470 Asn Val Ala Val Thr 550 Asp His Asp Val Ser Val Asn Pro 375 Arg Val Lys His Ala 455 Ala Ala Ala Ala Leu 535 Asp Pro His Thr Leu Leu Leu Leu Thr Ile 360 Asn Ile Asn Val Arg 440 Ala Val Ala Leu Ala 520 Asp Gly Glu Ala Gly 600 Leu Val 345 Pro Thr Ala Asp Arg 425 Trp Ile Val Phe Ala 505 Arg Asp Glu Leu Ile 585 Ala Ala 330 Val Val Thr Ala Lys 410 Val Val Arg Asp Thr 490 Leu His Val Met Val 570 Ser Gly Ala 315 Glu Arg Gin Ile Ser 395 Val Ile Lys Ser Phe 475 Thr Ser Gly Asp Thr 555 Leu Lys Gly Gly Leu Lys Glu Pro 380 Ile Phe Arg Glu Ala 460 Cys Thr Ala Ile Thr 540 Val Arg Ala Glu Arg Leu Gly Arg His Arg 350 Val Arg 365 Val Asp Ile Met Ala Gly Thr Gly 430 Ala Thr 445 Gly Asn Leu Trp Leu Ala Pro Leu 510 Leu Val 525 Ala Val Glu Thr Val Ala Leu Val 590 Asp Val 605 Leu Leu 335 Leu Val Gly Gly Ser 415 His Leu Leu Ala Val 495 Ala Arg Phe Val Gly 575 Lys Pro Thr 320 Gin Lys Asn Thr Gin 400 Leu Arg Lys Val Leu 480 Leu Thr Ser Asn Thr 560 Ala Ala His Trp Ile Glu Val Gly Asn Val Glu Ile Thr Glu Ala Gly Ser Phe Gin 841 Ala Thr Ile Glu Leu Pro Leu Ile Lys Pro Ser Gly Glu Lys Ile Met 625 630 635 640 Arg Thr Thr Glu Ala Leu Leu Trp Arg Pro Arg Ser Met Thr Glu Val 645 650 655 Arg Giu His Leu Ser Pro Arg Leu Val Ala Ala Ala Thr Ser Gly Gly 660 665 670 Ala Pro Leu Ile Val Arg Trp Lys Gly Lys Asp Arg Gly Val Ile Thr 675 680 685 Leu Ser Asp His Val Arg Ser Asp Ser Ser Asp Ala Ile Ile Ala Ile 690 695 700 Glu Giu Gin Gly Ile Giu Thr Met Met Leu Ser Arg Asp Thr Tyr Pro 705 710 715 720 Val Ala Arg Arg Tyr Ala Asp Ser Leu Gly Ile Thr His Val Leu Ala 725 730 735 Gly Ile Ala Pro Gly Lys Lys Ala Gin Val Val Arg Ala Val His Thr 740 745 750 Arg Gly Ser Thr Val Ala Met Ile Gly Asp Giu Ser Val Met Asp Cys 755 760 765 Leu Lys Val Ala Asp Val Gly Val Leu Met Gly Val Asp Arg Pro Ser 770 775 780 Asp Leu Arg Asp Asp Ser Asp Asp Pro Ala Ala Asp Val Val Val Met 785 790 '795 Boo Arg Giu Giu Val Met Ser Val Pro Thr Leu Plie Lys Leu Ala Arg Arg 805 810 815 Tyr Ala Lys Leu Val Asn Gly Asn Ile Ala Leu Ala Trp Ile Tyr Asn 820 825 830 Gly Vai Ala Met Val Leu Ala Val Ser Gly Leu Leu His Pro Met Ala 835 840 845 Ala Thr Val Ala Met Leu Ala Ser Ser Leu Leu Ile Giu Trp Arg Ser 850 855 860 Gly Arg Ala Arg Lys Tyr 865 870 <210> 579 <211> 1925 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (1)..(1902) <223> RXN01338 <400> 579 aaa act tat acc cca aat ccc tgg atg tta ttc atc cgc tca ttt gat 48 Thr Tyr Thr Pro Asfl Pro Trp Met Leu 10 Phe Ile Arg Ser Phe Asp ggc atc atc Gly Ile Ile tta tgg ctg Leu Trp Leu gtc gca gCC ctt Val Ala Ala Leu gcc atc gca ata Ala Ile Ala Ile cat ctc att His Leu Ile tgg cct tta Trp Pro Leu gct cta gat cta Ala Leu Asp Leu ggc ctt gct aaa Gly Leu Ala Lys aac As n ata gcc Ile Ala atc gtt atc gta ggt ggc att ccg ttg Ile Val Ilie Val Gly Gly Ile Pro Leu tgg gat gtg ctg Trp Asp Val Leu tca gcc att aaa Ser Ala Ile Lys act Thr cgc ggt ggc gcg Arg Gly Gly Ala act tta gca gca Thr Leu Ala Ala 240 288 tcc atc att act Ser Ile Ilie Thr tct Ser gtg ttg tta ggg Val Leu Leu Gly gag Giu 90 tgg ttg gtt gcc Trp Leu Val Ala gcg atc Ala Ile atc gtg ctc Ilie Val Leu cgg cga gcc Arg Arg Ala 115 atg Met 100 ctc tct ggt ggt Leu Ser Gly Gly gcg cta gaa gag Ala Leu Glu Glu gca gca tca Ala Ala Ser 110 gca cca agt Ala Pro Ser agt ggc acc ttg Ser Gly Thr Leu gca ctt gcc cgg Ala Leu Ala Arg cgc Arg 125 aca gct Thr Ala 130 cac cgc ctg ttg His Arg Leu Leu gca acc att ctt Ala Thr Ile Leu gat Asp 140 gga acc gaa gag Gly Thr Giu Glu atc Ile 145 gcc gtg gaa gag Ala Val Glu Glu acg gtt ggt qat Thr Val Gly Asp tta Le u 155 gtg gcg gtg ctc Val Ala Val Leu cg Pro 160 cat gaa ctt tqt His Glu Leu Cys ccc Pro 165 gtg gat gqt qaa Val Asp Gly Giu gtg gca ggc cac Val Ala Gly His ggc acc Gly Thr 175 atg gat gag Met Asp Giu aaa ggt tcg Lys Gly Ser 195 tat ctc acg ggt Tyr Leu Thr Gly ccc tat gtg gtg Pro Tyr Val Vai agt aaa tct Ser Lys Ser 190 act ccg ctg Thr Pro Leu caa gca atg tcg Gin Ala Met Ser gca gtc aat ggt Ala Val Asn Gly acg att Thr Ile 210 gtt gcc aca aag Val Ala Thr Lys gcc cat gat tcc Ala His Asp Ser a ga Arg 220 tac gcc caa att Tyr Ala Gin Ile ggt gta ctc cat Gly Val Leu His qaa Glu 230 gca gaa aac aac Ala Giu Asn Asn cgc Arg 235 cca gaa atg cgc Prc Giu Met Arg agg Arg 240 aty gct gac cgt ctt ggc gcg tgg .at acg gtg att gca ctt gcc ctc Met Ala Asp Arg Leu Gly Ala Trp Tyr Thr Val Ile Ala Leu Ala Leu ggt ggt ctt Gly Gly Leu gtt gtc gtt Val Val Val 275 ggc Gi y 260 tgg att gtc tcc Trp Ile Val Ser ggc Gly 265 gac cca gtg agg Asp Pro Val Arg ttc ttg gct Ph-e Leu Ala 270 gtg cca gtg Val Pro Val 816 864 gtc qcc acc cca Val Ala Thr Pro cca ttg ctc att Pro Leu Leu Ile gcg atc Ala Ile 290 atc ggt gcg att Ile Gly Ala Ile ctt gcg. gct cgt Leu Ala Ala Arg ggc atc atc gtg Gly Ile Ile Val aag Lys 305 aac cct gqa atg Asn Pro Gly Met ctg Le u 310 gaa aac gct tca Giu Asn Ala Ser gga Gly 315 gta aag aca gtg Val Lys Thr Val 912 960 1008 ttc gat aag act Phe Asp Lys Thr gga Gly 325 acg ctc acc tat Thr Leu Thr Tyr agg cca gtg att Arg Pro Val Ile act gat Thr Asp 335 atc cac act Ile His Thr gct tca gta Ala Ser Val 355 g ct Al a 340 ccc gga gtt gag Pro Gly Val Glu gat aca gtc cta Asp Thr Val Leu gct ttg gct Ala Leu Ala 350 gcg att cgt Ala Ile Arg 1056 1104 gag cgc tac tcc Glu Arg Tyr Ser aga Arg 360 cac ccg ttg gct His Pro Leu. Ala gac Asp 365 gag ggc Glu Gly 370 gca aaa gcc agg Ala Lys Ala Arg gaa Giu 375 ctt cat ctg cct Leu His Leu Pro ga t Asp 380 gta gtg gaa gta Val Val Glu Val gaa cgt cca gga Glu Arg Pro Gly gga cta acc ggc Gly Leu Thr Gly gtg ggc gag cac Val Gly Glu His1 1152 1200 1248 gtt cga ata acc Val Arg Ile Thr aa t Asn 405 agg cgc agc aca Arg Arg Ser Thr cta Le u 410 gaa att gat cca Gl Ile Asp Pro gac agc Asp Ser 415 aag aac tac Lys Asn Tyr gtt gat gat Val Asp Asp 435 ccg gtg aca agt Pro Val Thr Ser ggc atg gaa tct Gly Met Glu Ser gtg gtg ctt Val Val Leu 430 gaa cct cgt Glu Pro Arg 1296 1344 aaa tat gca gca Lys Tyr Ala Ala att cgc ctc cgg Ile Arg Leu Arg gat Asp 445 gca tct Ala Ser 450 gcc agt gag ttc Ala Ser Glu Phe gog cac ttg ccc Ala His Leu Pro aag Lys 460 aag cac aaa gtg Lys His Lys Val gac Asp 465 aag ctc atg att Lys Leu Met Ile atc Ile 470 tct ggt gat cgc Ser Gly Asp Arg g ca Ala 475 tct gag gtt cgt Ser Glu Val Arg tac Tyr 480 1392 1440 1488 ctt gcg gac aag Leu Ala Asp Lys ggc att gat gag Gly Ile Asp Glu cac gca gag gcc His Ala Glu Ala tca ccg Ser Pro 495 gaa qac aag ctg aac att gtt aat cgg cat aat gag cac ggc gcc acc Glu Asp Lys Leu Asn Ile Val Asn Arg His Asn Glu His Gly Ala Thr 1536 500 505 510 atg Met acc Thr gca Ala 545 ctc Leu ggt Gly ttc Phe ct g Leo t tc Phe gtt Val1 530 gat Asp cac His ggc Gly ttg Leu gct Ala 610 tta Le u 515 ggt Gly gct Al a atc Ile atg Met a og Thr 595 atc Ile ggt Gly gt c Val1 gtg Val1 agt Ser gog Al a 580 cca Pro ctc Le u gga Gly atg Met ttg Le u 550 cgq Arg agt Ser atq Met t cc Ser a tc Ile gga Gly 535 gat Asp atg Met gtc Val1 ggt Gly qct Al a 615 gcg Ala tcc Se r ctq Le u ata Ile 570 atq Met ttc Phe gca Ala gcc Ala gtc Val1 540 cgt Arg ttg Leu ctc Leu gag Glu cca atg Met 525 acg Th r ct C Leu ca a Gin gcg Al a qtc Val1 605 cgc gt t Val1 gaa Glu ga t Asp gag Al a 575 ttt Phe ga c Asp gcg gcc Al a gca Al a ctg Leu 560 ggC Gi y gg a Gly gtg Val1 att 1584 1632 1680 1728 1776 1824 1872 1922 Leu Pro Arg Gly Ala Ile 620 tagcagggta acctaaatgt aqt gat ttt qat acg caa gaa aaa gtt tct Ser Asp Phe Asp Thr Gin Glu Lys Val Ser 625 630 cg t <210> 580 <211> 634 <212> PRT <213> Corynebacterium giutamicun <400> 580 Lys Thr Tyr Thr Pro Asn Pro Trp Met Leu 1 5 Gly Ile Ile Thr Val Ala Ala Leu Val Ala Leu Trp Leu Ala Leu Asp Leu Asp Gly Leu 40 Ile Ala Ile Val Ile Val Gly Gly Ile Pro Lys Ser Ala Ile Lys Thr Arg Gly Gly Ala 70 1925 Arg Ile Asn Trp Leu Asp Ile Leu Leu Val1 Ser Ile Ile Thr Ser Val Leu Leu Gly Glu Trp Leu Val Ala Ala Ile 90 Ile Arg Thr Ile 145 His Met Lys Thr Val 225 Met Gly Val1 Al a Lys 305 Phe Ile Al a Glu Ser 385 Val1 Val1 Arg Al a 130 Al a Glu Asp Gly Ile 210 Gly Ala Gly Val1 Ile 290 As n Asp His Se r Gly 370 Glu Ar g Leu Ala 115 His Val1 Leu Glu Ser 195 Val1 Val1 Asp Leu Val 275 Ile Pro Lys Thr Val 355 Ala Arg Ile Met 100 Ser Arg Glu Gys Ser 180 Gin Al a Leu Ar g Gi y 260 Val1 Gi y Gi y Tb r Ala 340 Gli Lys Pro Thr Le u Gi y Le u Glu Pro 165 Tyr Al a Thr His Le u 245 Trp Al a Ala Met Gly 325 Pro Arg Al a Gly As n Ser Thr Le u Ile 150 Val1 Leu Met Lys Giu 230 Gly Ile Thr Ile Le u 310 Thr Gly Tyr Arg Gin 390 Arg Gly Gly Leii Asp 120 Gly Ala 135 Thr Val Asp Gly Thr Gly Ser Gly 200 Leu Ala 215 Ala Giu Ala Trp Val Ser Pro Cys 280 Ser Leu 295 Glu Asn Leu Thr Val Glu Ser Arg 360 Glu Leu 375 Gly Leu Arg Ser Glu Ala 105 Ala Leu Thr Ile Gly Asp Glu Ile 170 Glu Pro 185 Ala Val His Asp Asn Asn Tyr Thr 250 Gly Asp 265 Pro Leu Ala Ala Ala Ser Tyr Gly 330 Glu Asp 345 His Pro His Leu Thr Gly Thr Leu Le u Al a Leu Leu 155 Val1 T yr Asn Ser Arg 235 Val Pro Leu Arg Gly 315 Arg Thr Leu Pro Thr 395 Glu Glu Arg Asp 140 Val1 Ala Val1 Gly Arg 220 Pro Ile Val1 Ile Arg 300 Val1 Pro Val1 Al a Asp 380 Val1 Ile Glu Arg 125 Gi y Ala Gly Val1 Asp 205 T yr Glu Ala Arg Al a 285 Gly Lys Val1 Leu Asp 365 Val1 Gi y Asp Ala Ala 110 Ala Pro Thr Glu Val Leu His Gly 175 Ser Lys 190 Thr Pro Ala Gin Met Arg Leu Ala 255 Phe Leu 270 Val Pro Ile Ile Thr Val Ile Thr 335 Ala Leu 350 Ala Ile Val Glu Glu His Pro Asp Ser Ser Glu Pro 160 Tb r Se r Le u Ile Arg 240 Leu Al a Val1 Val1 Met 320 Asp Al a Arq Val1 Le u 400 Se r 405 410 415 Lys Asn Tyr Ilie Pro Val Thr Ser Ser Gly Met Glu Ser Val Val Leu 420 425 430 Val Asp Asp Lys Tyr Ala Ala Leu Ile Arg Leu Arg Asp Glu Pro Arq 435 440 445 Ala Ser Ala Ser Giu Phe Ile Ala His Leu Pro Lys Lys His Lys Val 450 455 460 Asp Lys Leu Met Ile Ilie Ser Gly Asp Arg Ala Ser Giu Val Arg Tyr 465 470 475 480 Leu Ala Asp Lys Val Gly Ile -Asp Glu Val His Ala Giu Ala Ser Pro 485 490 495 Glu Asp Lys Leu Asn Ilie Val Asn Arg His Asn Glu His Gly Ala Thr 500 505 510 Met Phe Leu Gly Asp Gly Ile Asn Asp Ala Pro Ala Met Ala Val Ala 515 520 525 Thr Val Gly Val Ala Met Gly Ala Asp Ser Asp Val Thr Ser Glu Ala 530 535 540 Ala Asp Ala Val Ile Leu Asp Ser Ser Leu Glu Arg Leu Asp Asp Leu 545 550 555 560 Leu His Ilie Ser Ala Arg Met Arg Arg Ilie Ala Leu Gin Ser Ala Gly 565 570 575 Gly Gly Met Ala Leu Ser Val Ile Gly Met Ilie Leu Ala Val Phe Gly 580 585 590 Phe Leu Thr Pro Leu Met Gly Ala Ile Phe Gin Glu Val Ile Asp Val 595 600 605 Leu Ala Ilie Leu Asn Ser Ala Arg Val Ala Leu Pro Arg Gly Ala Ile 610 615 620 Ser Asp Phe Asp Thr Gin Glu Lys Val Ser 625 630 <210> 581 <211> 1917 <212> DNA <213> Corynebacterium giutamicum <220> <221> CDS <222> (101) (18 94) <223> RXN00980 <400> 581 agagagaaag ggagaaatca tgaaaacgtg qaagacctgg ggggtcgtcg gagcttcagg cctcttgatt attttgtcgt gqttqaqttc atcgagcccg atg ctg qca gat gca 115 Met Leu Ala Asp Ala 1 ttc Phe gca Ala gtt Val1 geg Al a aca Thr ca Pro gag Giu gaa Giu gat Asp gge Gly 150 gtc Val1 cac His tta Leu gca Ala tta Leu 230 atg Met tat Tyr gtg Val1 9gg Ala atg Met gaa Glu Ctg Leu caa Gin gaa Giu 135 tot Ser gag Giu c Arg gag Glu gt g Val1 215 gtg Val1 atc Ile caa Gin gct Ala gtg Val1 aac Asn act Thr t gg T rp att Ile 120 tee Ser ga t Asp g ca Ala gtt Val1 aaa Lys 200 gtg Val1 atc Ile 9g Al a gca Ala gee Al a a cg Thr cgc Arg gca Al a gag Giu 105 Ccc Pro aac As n gt g Val1 aca Thr gaa Gi u 185 ttc Phe gg a Gly ggo Gly gCt Al a ct t Leu gtt Val1 ttC Phe aca Thr aca Thr ott Leu gte Val1 ate Ile tat T yr gga Gly 170 gao Asp tot Ser ott Leu tgo Cys gca Al a ego Arg ggt GlIy etc Leu cga Arg 75 agg Arg gag Giu ga t Asp acg Thr gca Al a 155 att Ile gee Al a aag Lys ato Ile coo Pro 235 att Ile att Ile gee Ala ttt Phe 60 aaa Lys etc Leu 000 Pro gga Gly ggt Gly 140 gga Gly ggt Gly cag Gin t gg T rp acc Thr 220 ggo Gly gt t Val1 oga Arg at g Met 45 gee Al a gca Al a aac As n ggt Gi y aac As n 125 g a a Glu ace Thr tea Se r ga t Asp tao Tyr 205 tgg Trp 9g Ala gca Ala atg Met 30 ttC Phe ott Le u eta Leu geg Ala gao Asp 110 gt g Val1 tea Ser t gg Trp gac Asp gao Asp 190 aco Thr gac Asp ttg Leu ggt Gly 15 gtg Val ato Ile gge Gly tog Ser gat Asp 95 ate Ile att Ile atg Met otg Le u toa Ser 175 aaa Lys cog Pro gt a Val1 gt t Val1 t gg T rp tog Ser aac Asn aag Lys gat Asp 80 gao Asp gte Val1 gog Al a cog Pro ega Arg 160 act Thr gee Al a ggo Gly gaa Gi u ate Ile 240 cog Pro att Ile aae As n goa Al a ctg Leu tea Ser ttg Leu ggt Gly get Ala 145 tot Ser ttg Leu ego Arg gte Val1 eta Leu 225 tee Ser ate Ile gao Asp tat Tyr ot g Leu gt g Val1 aca Th r gt a Val1 gte Val1 130 g a a Giu ggt Gly gca Ala aca Thr atg Met 210 gca Ala ate Ile geg Al a tta Leu t gg Trp gaa Glu gat Asp gag Glu ego Arg 115 ggt Gi y aag Lys gtt ValI aaa Lys ca a Gin 195 ate Ile ct g Leu cog Pro cag Gin etg Leu gag Glu ego Arg gca Ala gta Val 100 aat As n gga Gly ggt Gi y ttg Leu ate Ile 180 aca Thr gee Ala a eg Th r gt g Val tot Ser gte Val1 tot Se r geg Ala get Ala gt t Val ggo Gly att Ile caa Gin a ga Arg 165 att Ile ttc Phe gee Ala etc Leu toe Ser 245 163 211 259 307 355 403 451 499 547 595 643 691 739 787 835 atc gtc gca ggc Ile Val Ala Gly ato Ile 250 ggo cgt gct gca Gly Arg Ala Ala cgc Arg 255 gat ggc qtg ctg Asp Gly Val Leu atc aag Ile Lys 260 883 ggt gga gaa Gly Gly Glu gac aaa act Asp Lys Thr 280 ota gaa acc gcc Leu Giu Thr Ala aaa gtc qac gtc Lys Val Asp Val gtt gtc qtg Val Val Val 275 aca gac gta Thr Asp Val 931 979 gga acg ctg acc Gly Thr Leu Thr ggc cgc cca gaa Gly Arg Pro Glu gaa gtc Glu Val 295 atc gag ccc gcc Ile Glu Pro Ala tac Tyr 300 agc cag ggc gag Ser Gin Gly Giu gtg Val1 305 ctg gag ctc gcc Leu Glu Leu Ala gcg Al a 310 ogc goc gag acg Arg Ala Glu Thr tca gaa cat ccg Ser Glu His Pro gcc gao gcc atc Ala Asp Ala Ile 1027 1075 1123 ogt ggt goc cag Arg Gly Ala Gin gat Asp 330 cgg ggg ctg tco Arg Gly Leu Ser aca ttg gtg gaa Thr Leu Val Giu gca gct Ala Ala 340 gaa aac ato Glu Asn Ilie gtt gct gtt Val Ala Val 360 aco Thr 345 ggc oga ggc att Gly Arg Gly Ile atc Ile 350 goa aat gtt gat Ala Asn Val Asp gqa cag gca Gly Gin Ala 355 gao tcg ac Asp Ser Thr gga tct gct gag Gly Ser Ala Glu ctt gat cat gaa Leu Asp His Glu oca Pro 370 agg atc Arg Ile 375 otg gag ota aat Leu Glu Leu Asn gga cac goc att Gly His Ala Ile 395 gaa gga aag acc Glu Gly Lys Thr gog Al a 385 atg ttt gtc gga Met Phe Vai Gly gtg Val 390 aac As n gga atc gtg gcc Gly Ile Val Ala gcc gac gcc gtt Ala Asp Ala Val 1171 1219 1267 1315 1363 1411 1459 tca gat tot gcc Ser Asp Ser Ala t ca Ser 410 gca atc gaa tog Ala Ile Giu Ser ctg cat aag Leu His Lys 415 ogo gtt gca Arg Val Ala gtt gtc atg Val Val Met tco aag ctg Ser Lys Leu 440 act ggo gac gct Thr Gly Asp Ala gcg ggo att oaa Ala Gly Ile Gin 420 caa aao gtg gc Gin Asn Val Ala 435 oto oct gaa cag Leu Pro Glu Gin 450 aaa acg gtc gcg Lys Thr Val Ala gga gtg gat gaa Gly Val Asp Glu tac toa gag cta Tyr Ser Glu Leu aaa tta Lys Leu 455 gaa otg gtg cgt Giu Leu Val Arg otg caa gct gc Leu Gin Ala Ala ggc Gly 465 1507 1555 a tg Met 470 gtg ggt gac gga Val Gly Asp Gly gt c Val 475 aac gac acc cca Asn Asp Thr Pro goa Ala 480 ttg gca got got Leu Ala Ala Ala atc gga gta gog atg ggc gtg gos ggt too oct qca gcc att gaa aco 1603 Ile get Al a gtg Val1 att Ile gga Gly 550 ctt Leu gat Asp gca Ala Val ate Ile ttg Leu 520 ttg Leu ace Thr ate Ile gcg Al a Met 490 etc Leu aaa Lys ace Thr t eq Ser ate Ile 570 gea Gi y atg Met eq e Arg gt g Val1 gt t Val1 555 gee Al a ag t Gliy eq t Arg 510 aga Ar g tta, Le u etc Le u ttg Leu aaa Lys 590 Ser Pro Ala 495 etc eca egg Leu Pro Arg ace atg eqe Thr Met Arg eta. get gge Leu Ala Gly 545 gtt cac gaa Val His Glu 560 etg egt eca, Leu Arg Pro 575 ege teg gaa Arg Ser Glu Ile gea Ala 515 aat As n eta Le u age Ser ctt Le u eaa Glu 500 cat His at t Ile ttt Phe gtg Val1 aaa Lys 580 eag Thr gea Ala etg Leu 99c Gly etg Leu 565 gaa Glu ate 1651 1699 1747 1795 1843 1891 Gin Ala Ser Asp Ile 585 Ile Gin Gln Ile 595 taaeeaatgg ctgggtactg atg. 1917 <210> 582 <211> 598 <212> PRT <213> Corynebacterium giutariium <400> 582 Met Leu Ala Asp Ala Phe Met Ile Ala 1 5 Pro Ile Ala Gln Ser Ala Tyr Gin Ala 25 Ile Asp Leu Leu Val Vai Val Ala Ala 40 Asn Tyr Trp Giu Ser Ala Ala Val Thr 55 Ala Leu Glu Arg Ala Thr Met Asn Arg 70 Leu Val Asp Ala Ala Pro Giu Thr Ala Ser Thr Giu Val Val Glu Leu Trp Glu 100 105 Leu Val Arg Asn Gly Giu Gin Ile Pro 115 120 Al a 10 Le u Val1 Phe Thr Thr 90 Leu Val1 Al a Arg Gly Leu Arg 75 Arg Giu Asp Ile Ile Al a Phe Lys Leu Pro Gly Val1 Arg Met Ala Al a As n Gi y As n 125 Ala Met Phe Leu Leu Ala Asp 110 Val Gly Val Ile Gly Ser Asp Ile Ile Trp Ser As n Lys Asp Asp Val1 Al a Gly Ala 145 Ser Leu Arg Val Leu 225 Ser Gly Asp Glu Val 305 Ala Leu Val Glu Ala 385 Ala Lys Ala Val 130 Glu Gly Ala Thr Met 210 Ala Ile Val Val Leu 290 Leu Asp Val Asp Pro 370 Met Asp Ala Gin Gly Lys Val Lys Gin 195 Ile Leu Pro Leu Val 275 Thr Glu Ala Glu Gly 355 Asp Phe Ala Gly Asn 435 Gly Gly Leu Ile 180 Thr Ala Thr Val Ile 260 Val Asp Leu Ile Ala 340 Gin Ser Val Val Ile 420 Val Ile Gin Arg 165 Ile Phe Ala Leu Ser 245 Lys Val Val Ala Ile 325 Ala Ala Thr Gly Arg 405 Gin Ala Asp Gly 150 Val His Leu Ala Leu 230 Ile Gly Asp Glu Ala 310 Arg Glu Val Arg Val 390 Ser Val Ser Glu 135 Ser Glu Arg Glu Val 215 Val Val Gly Lys Val 295 Arg Gly Asn Ala Ile 375 Asn Asp Val Lys Ser Asp Ala Val Lys 200 Val Ile Ala Glu Thr 280 Ile Ala Ala Ile Val 360 Leu Gly Ser Met Leu 440 Asn Val Thr Glu 185 Phe Gly Gly Gly Tyr 265 Gly Glu Glu Gin Thr 345 Gly Glu His Ala Ala 425 Gly Ile Tyr Gly 170 Asp Ser Leu Cys Ile 250 Leu Thr Pro Thr Asp 330 Gly Ser Leu Ala Ser 410 Thr Val Thr Ala 155 Ile Ala Lys Ile Pro 235 Gly Glu Leu Ala Ala 315 Arg Arg Ala Asn Ile 395 Ala Gly Asp Gly 140 Gly Gly Gin Trp Thr 220 Gly Arg Thr Thr Tyr 300 Ser Gly Gly Glu Ala 380 Gly Ile Asp Glu Glu Thr Ser Asp Tyr 205 Trp Ala Ala Ala Thr 285 Ser Glu Leu Ile Leu 365 Glu Ile Glu Ala Val 445 Ser Trp Asp Asp 190 Thr Asp Leu Ala Ala 270 Gly Gin His Ser Ile 350 Leu Gly Val Ser His 430 Tyr Met Leu Ser 175 Lys Pro Val Val Arg 255 Lys Arg Gly Pro Thr 335 Ala Asp Lys Ala Leu 415 Arg Ser Pro Arg 160 Thr Ala Gly Glu Ile 240 Asp Val Pro Glu Leu 320 Thr Asn His Thr Val 400 His Val Glu Le u Gly 465 Leu Ala Arg Arg Gly 545 Glu Pro Giu Giu Val1 Al a Glu 500 His Ile Phe Val1 Lys 580 Gln Gin Al a Asp 485 Thr Ala Leu Gly Leu 565 Giu Ile Lys Met 470 Ile Ala Val1 Ile Gly 550 Le u Asp Al a Leu 455 Val Gly Asp Thr Al a 535 Val1 Val1 Ala Leu Asp Ala Ala 505 Ala Ala Met Ser Gin 585 Val Gly Met 490 Le u Lys Thr Ser Ile 570 Al a Asp 460 Asn Val1 Ala Thr Met 540 Gly Met Asp Leu Asp Al a Asp ValI 525 Val Met Leu Ile Gin Th r Gly Arg 510 Arg Leu Le u Leu Lys 590 Al a Pro Ser 495 Le u Thr Leu ValI Leu 575 Arg <210> 583 <211> 1296 <212> DNA <213> Corynebacterium glutamicui <22 0> <221> CDS <222> (1273) <223> RXN00099 <400> 583 otctggtgaa gagqatgttg actcggqaga ttcttccact ccgcgcaaat aggtagtcgc ttgcttatag ggtcaggggc otc ata gca ctg gcc got atc ato ctg acc tcg Leu Ile Ala Leu Ala Ala Ile Ile Leu Thr Ser 15 gct att act gct tta got cog ctg gtt tct gag Ala Ile Thr Ala Leu Ala Pro Leu Val Ser Glu 30 ggg gtt aqt gct tct Ott att ggt gtg ttg gqc Gly Val Ser Ala Ser Leu Ile Gly Val Leu Gly 45 atg ttc gcg gat got gcg ttt gcg ott ccg tcg gattcaotqa ttaagtqqta gtg aag aat cot ogo 115 Val Lys Asn Pro Arg 1 ttc aat ctg oga aca 163 Phe Asn Leu Arg Thr att cgg gat gat tta 211 Ile Arg Asp Asp Leu atg ato cog act got 259 Met Ile Pro Thr Ala ttg aag agg aag ttc 307 Met Phe Ala Asp Ala Ala Phe Ala Leu Pro Ser Leu Lys Arg Lys Phe 60 act act tcc caa ctg ttg atg ttt gcc atq ctg ttg act gct gcc ggt 355 Thr Thr Ser Gin Leu Leu Met Phe Ala Met Leu Leu Thr Ala Ala Gly 75 80 cag att att cgt gtc gct gga cct gct tcg ctg ttg atg gtc ggt act 403 Gin Ile Ile Arg Val Ala Gly Pro Ala Ser Leu Leu Met VJal Gly Thr 95 100 gtq ttc gcg atg ttt gcq atc gqa gtt acc aat gtg ttg ctt ccg att 451 Val Phe Ala Met Phe Ala Ile Gly Val Thr Asn Val Leu Leu Pro Ile 105 110 115 gct gtt agg gag tat ttt ccg cgt cac gtc gqt gga atg tcg aca act 499 Ala Val Arg Giu Tyr Phe Pro Arg His Val Gly Gly Met Ser Thr Thr 120 125 130 tat ctg gtg tcg ttc cag att gtt cag gca ctt gct ccg acg ctt gcc 547 Tyr Leu Val Ser Phe Gin Ile Val Gin Ala Leu Ala Pro Thr Leu Ala 135 140 145 gtg ccg att tct cag tqg gct aca cat gtg ggg ttg acc ggt tgg agg 595 Val Pro Ile Ser Gin Trp Ala Thr His Val Giy Leu Thr Gly Trp Arg 150 155 160 165 gtg tcg ctc ggt tcg tgg gcg ctg ctg ggg ttg gtt gcg gcg att tcg 643 Val Ser Leu Gly Ser Trp Ala Leu Leu Gly Leu Val Ala Ala Ile Ser 170 175 180 tgg att ccg ctg ttg agt ttg cag ggt gcc agg gtt gtt 9C9 9C9 CCg 691 Trp Ile Pro Leu Leu Ser Leu Gin Gly Ala Arg Val Val Ala Ala Pro 185 190 195 tcg aag gtt tct ctt cct gtg tgg aag tct tcg gtt ggt gtg ggg ctc 739 Ser Lys Val Ser Leu Pro Val Trp Lys Ser Ser Val Gly Val Gly Leu 200 205 210 ggg ttg atg ttt ggg ttt act tcg ttt gcg acg tat atc ctc atg qgt 787 Gly Leu Met Phe Gly Phe Thr Ser Phe Ala Thr Tyr Ile Leu Met Gly 215 220 225 ttt atg ccg cag atg gta ggt gat cct cag ctc ggt gcq gtg ttg tta 835 Phe Met Pro Gin Met Val Gly Asp Pro Gin Leu Gly Ala Val Leu Leu 230 235 240 245 ggc tgg tgg tca att ttg gga ttg ccg ctg aac att ctg gga ccg tgg 883 Gly Trp Trp Ser ile Leu Gly Leu Pro Leu Asn Ile Leu Giy Pro Trp 250 255 260 ttg gtg acg cgt ttc act aac tgc ttc ccg atg gtt gtt atc gcc agt 931 Leu Val Thr Arq Phe Thr Asn Gys Phe Pro Met Val Val Ile Ala Ser 265 270 275 gtc atq ttt ctc atc ggt aat ggt ggg ttt tgt ttg gct ccg gat gtt 979 Val Met Phe Leu Ile Gly Asn Gly Gly Phe Cys Leu Ala Pro Asp Val 280 285 290 gcg ccg tgg ttg tgg gcg acg ttg tct ggt ctt ggt ccc ctt gcg ttc 1027 Ala Pro Trp Leu Trp Ala Thr Len Ser Gly Leu Gly Pro Leu Ala Phe 295 300 ccg atg qcg ttg acg ctc att aat att Pro Met Ala Leu Thr Leu Ie Asn Ile 310 315 gct tct gcg ttg agt tcc ttc ggg cag Ala Ser Ala Leu Ser Ser Phe Gly Gin 330 tgt ttc ggt ccc ttg ttg act ggt ttc Cys Phe Gly Pro Leu Leu Thr Gly Phe 345 350 ttc cga aca atc ttt gtg ctt ttt qcg Phe Arg Thr Ile Phe Val Leu Phe Ala 360 365 aga ggc ggt tac ttt qcg aca agg cag Arq Gly Gly Tyr Phe Ala Thr Arg Gin 375 380 aat cgc taggatggcg ctatgccqca aaq Asn Arg 390 <210> 584 <211> 391 <212> PRT (213> Corynebacterium glutamicum gct Ala 320 ttg La u gtc Val1 gca Al a tac Tyr act Thr tat T yr g cg Ala ctc Le u 370 gaa Glu agt Ser acg Thr aca Thr 355 ttc Phe aag Lys gg t Gly 325 9c9 Ala agc Ser att Ile tta La u 1075 1123 1171 1219 1267 1296 <400> 584 Vai Lys Asn Pro 1 Phe I le Met Le u Le u Le u Val1 Gly Al a Asn Arg Ilie Lys Thr Met Leu Met 130 Pro Leu Asp Pro Arg Ala Val1 Leu 115 Ser Thr Arg Asp Thr Lys Al a Gi y 100 Pro Thr Leu Ar g 5 Th r Le u Al a Phe Gi y Th r Ile Thr Ala Leu Ile Ala Leu Al a Gly Met Thr 70 Gin Val1 Ala Tyr Val1 Ile Val1 Phe 55 Thr Ile Phe Val1 Le u 135 Pro Thr Ser 40 Ala Ser Ile Ala Arg 120 Val Ile Al a 25 Al a Asp Gin Arg Met 105 Glu Ser Ser Al a 10 Leu Ser Ala Leu Val 90 Phe Tyr Phe Gin Ala Al a Leu Ala Leu 75 Ala Al a Phe Gin T rp Ile Pro Ile Phe Met Gly Ile Pro Ile 140 Ala Ile Leu Gly Ala Phe Pro Gly Arg 125 Val Thr Leu Thr Val Ser Val Leu Leu Pro Ala Met Ala Ser Val Thr 110 His Val Gin Ala His Val Se r Glu Gly Se r Le u Leu As n Gly Leu Gly h. 155 160 Leu Thr Gly Trp Val Ala Ala Val Val Ala 195 Val Gly Val 210 Tyr Ile Leu 225 Gly Ala Val Ile Leu Gly Val Val Ile 275 Leu Ala Pro 290 Gly Pro Leu 305 Glu Thr Ser Gly Tyr Thr Asp Ala Thr 355 Thr Leu Phe 370 Val Glu Lys 385 <210> 585 (211> 387 <212> DNA Ile 180 Ala Gly Met Le u Pro 260 Ala Asp Ala Ala Ile 340 Gly Val1 Val1 T rp Ser Gly Ph e 230 Gly Leu ValI Ala Pro 310 Al a Cys Phe Arg Ser Ile Lys Leu 215 Met Trp Val1 Met Pro 295 Met Ser Phe Arg Gly 375 Leu Pro Val1 200 Met Pro Trp Thr Phe 280 Trp Ala Al a Gl y Thr 360 Gly Gly Leu 185 Ser Phe Gin Ser Arg 265 Leu Leu Leu Leu Pro 345 Ile T yr Se r 170 Leu Le u Gly Met Ile 250 Ph e Ile Trp Thr Ser 330 Leu Phe Phe Trp Ser Pro Phe Val1 235 Leu Thr Gly Ala Leu 315 Ser Le u Val1 Ala Al a Leu Val Thr 220 Gly Gly Asn Asn Thr 300 Ile Phe Thr Le u Th r 380 Le u Gln Trp 205 Ser Asp Leu Cys Gly 285 Leu Asn Gly Gi y Ph e 365 Ar g Le u Gly 190 Lys Phe Pro Pro Phe 270 Cl y Ser Ile Gin Phe 350 Al a Gin Gly 175 Al a Ser Al a Gln Leu 255 Pro Phe Gly Arg Gly 335 Ile Val1 Val1 Leu Arg Ser Thr Le u 240 As n Met Cys Leu Al a 320 Le u Val1 Ala Tyr Leu Leu Asn Arg <213> Corynebacterium glutamicun <220> <221> ODS <222> (364) <223> RXN02662 <400> 585 ccaaggtgtc accctcaccg ttgccatcgc cttcatcatc gtcaatatcg ccqtggacct gctctacgtc ctggtcaatc cacgtattag gaqcatctag acc Thr gca Ala t tc Phe gc Ala acc Thr gag Glu tta gaa aac aag ccc qgt gca Leu Glu Asn Lys Pro Gly Ala 15 cca act tca aaa atc gcg ctg Pro Thr Ser Lys Ile Ala Leu 30 qcg atc ttt qcc cca ctg att Ala Ile Phe Ala Pro Leu Ile act cca gtc cag cct cca agc Thr Pro Val Gin Pro Pro Ser atc ggc cgc gat att ttc tcc Ile Gly Arg Asp Ile Phe Ser 75 tgatcattgg tcttttcgct acg cga Arg gt t Val1 gct Ala ggt Gl y cgc Arg 80 atg Met 1 ctt Le u ttc Phe aaa Lys gag Glu gta Val1 cgt Arg ggc Gly ctc Le u gat Asp tgg Trp acg Thr aaa Lys t tc Phe ctg Leu cca Pro ttt Phe gcg Ala cta 115 Le u cgc 163 Arg atc 211 Ile ctg 259 Le u ggt 307 Gly cca 355 Pro <210> 586 <211> 88 <212> PRT <213> Corynebacterium qlutamicum <400> 586 Met Arg Arg Lys Leu Thr Thr ThrI 1 5 Leu Gly Gly Phe Arg Ala Leu Ala 1 PIhe Leu Leu Leu Ile Phe Leu Leu 40 Lys Tyr Asp Pro Leu Ala Ser Gly 55 Glu His Trp Phe Gly Thr Asp Ala 70 Val Ala Thr Ala Pro Glu Pro Pro <210> 587 <211> 972 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS Glu 10 Th r Ile Pro Gi y Lys Pro Gly Ala Lys Ile Ala Leu Ala Pro Leu Ile Gin Pro Pro Ser Asp Ile Phe Ser Arg Val1 Ala Gly Arg <222> (949) <223> RXN02442 <400> 587 gccgtgatgt tgttgagcgc gatqtgattg ccgtatgtgc agttctgcca ttccttaatg ataacggtta tcattttcaa atgtgagatt ccggacgctg atg aag ttt ttt act 11! Met Lys Phe Phe Thr gac gcc ctc ata Asp Ala Leu Ile cct ttt gac gtt Pro Phe Asp Val tea Ser ttc ate tcc cgc Phe Ile Ser Arg gee ctg Ala Leu gtc gee gga tgc ctg gcc gca att Val Ala Gly Cys Leu Ala Ala Ile tgc tca ctc att Cys Ser Leu Ile gga acg tgg Gly Thr Trp tcg cac gge Ser His Gly gtt att ttg Val Ile Leu cgc agg eta ac Arg Arq Leu Thr ttc ggc gac gct Phe Gly Asp Ala atg Met ttg etc Leu Leu ccc gga gta gcc Pro Gly Val Ala acg Thr gca tca cta ttg Ala Ser Leu Leu gqa aat etc atg Gly Asn Leu met ttc ggc gca gca atc Phe Gly Ala Ala Ile acc agc aga aaa tcc Thr Ser Arg Lys Ser gca tta atc aty Ala Leu Ile Met gcc gga gtg gtg Ala Gly Val Val t gy Trp agc ctc tcc caa Ser Leu Ser Gin gac Asp 95 gte age att ggc Val Ser Ile Gly ctg caa Leu Gin 100 ttt att ace Phe Ile Thr ctt tcc ctc ggc Leu Ser Leu Gly gt g Val1 110 gtt att gtg tcc Val Ile Val Ser cac tce gat His Ser Asp 115 att ctt ggc Ile Leu Gly tcc cac gcc gta Ser His Ala Val 120 gac ctc ace Asp Leu Thr agt ttc Ser Phe 125 ctt ttt gga Leu Phe Gly gtg cga Val Arg 135 ccc tcg gat ata Pro Ser Asp Ile ttC Phe 140 atc atc gcc att Ile Ile Ala Ile g ca Al a 145 aca gtg ttg ggt Thr Val Leu Gly ttg act att ttt Leu Thr Ile Phe ctc Le u 155 ttc cac ega cag Phe His Arg Gin act gca ctc gct Thr Ala Leu Ala gac gag cgt aaa Asp Glu Arg Lys cac acc tta gga His Thr Leu Gly aat ccc cgc ttt Asn Pro Arg Phe gca cac Ala His 180 cta ctc atg Leu Leu Met gtg gtg gga Val Val Gly 200 gca ctg atc gca Ala Leu Ile Ala qct acg gtg gtg Ala Thr Val Val tcg ttt cag Ser Phe Gin 195 ecg ccc qce Pro Pro Ala acg ctt tta qtq Thir Leu Leu Val ttt Phe 205 gqa ctt etc att Gly Leu Leu Ile a cg Thr atc Ile 230 atc Ile agt Ser agg Arg got Ala 215 gtc Val1 agc Ser got Al a tta Leu goa Al a gc9 Ala tgg T rp gog Ala aac As n 280 ct t Leu tog Ser cac His ata Ile 265 ttc Phe tta Leu ott Leu gca Ala 250 ttt Phe acc Thr gtg Val1 ott Leu 235 ago Se r ttt Phe gog Ala oaa gao aaa goa agt att toa Gln Asp Lys Ala Ser Ile Ser 220 225 gga tgo gog gaa att tao otc Gly Cys Ala Glu Ile Tyr Leu 240 aot gco gog gga goo act ato Thr Ala Ala. Gly Ala Thr Ile 255 goo aoo tta ttq aoa aag agt Ala Thr Leu Leu Thr Lys Ser 270 tqataotqaa agaoatttto aat atg Met tta Le u 245 tta Leu aqt Se r <210> 588 <211> 283 <212> PRT <213> Corynebaoterium glutarnioum <400> 588 Met Lys Phe Phe Thr Asp Ala Leu 1 5 Ile Ser Arg Ala Leu Val Ala Gly Leu Ile Gly Thr Trp Val Ile Leu 40 Ala Met Ser His Gly Leu Leu Pro 55 Gly Gly Asn Leu Met Phe Gly Ala 70 Ala Gly Val Val Trp Thr Ser Arg Ser Ile Gly Leu Gin Phe Ile Thr 100 Val Ser His Ser Asp Ser His Ala 115 120 Gly Asp Ilie Leu Gly Val Arg Pro 130 135 Ala Thr Val Leu Gly Giy Leu Thr 145 150 Thr Ala Leu Ala Phe Asp Glu Arg 165 Ilie Val Pro Phe Asp Val Ser Phe Cys Leu 25 Arg Arg Gly Val Ala Ilie Lys Ser 90 Met Leu 105 Val Asp Ser Asp Ile 'Phe Lys Ala 170 Ala Leu Ala Ser 75 Ser Ser Le u Ile Leu 155 His Al a Thr Thr Al a Le u Leu Thr Phe 140 Phe Th r Ile Phe Ala Leu Ser Gly Ser 125 Ile His Leu Leu Phe Ser Ile Gin Val1 110 Ph e Ile Arg Giy Cys Gly Leu Met Asp Val Leu Ala Gin Leu 175 Ser Asp Le u Se r Val Ile Phe Ile Phe 160 As n Pro Val1 Ile Ile 225 Tyr Thr Lys Phe Se r 195 Pro Le u Gi y Th r Aila 275 His Gin Ala Met Leu 245 Leu Ser Le u Val1 Thr Ile 230 Ile Ser Arg Met Gly 200 Al a Al a Trp Al a Asn 280 Le u 185 Thr Le u Ser His Ile 265 Phe Leu Le u Val1 Le u 235 Se r Phe Al a Ile Val1 Gin 220 Gly Thr Ala Leu 190 Gi y Lys Ala Al a Leu 270 Al a Le u Ala Giu Gly 255 Le u <210> 589 '<211> 1077 <212> DNA <213> Corynebacterium glutamicum <22 0> (221> CDS <222> (101)..(C1054) <223> RXN02443 <400> 589 eaagcactgc cgcgggaqec actatcactt tgttaagtgc tattgacaaa gagtgccatt agtaggttaa acttcaccgc tgcgatattt tttgccacct att Ile cga Arg atc I le ace Thr gat Asp gtc Val t tc Phe aaa Ly s ace Thr aac Asn gt c Val t ca Se r aa t Asn cta Le u gcc Ala ate Ile caa Gin gea Al a aat Asn cta Leu tgt Cys etg Le u gt a Val1 caa Gin ggg Gly gct Ala tee Ser ggt Gly ctc Leu gac Asp gag Glu gtt Val1 get Al a ga t Asp atg Met 75 gce Ala ctc Leu cca Pro gta Val1 gt t Val1 60 aaa Lys get Ala g gg Gly gtt Val 30 gac Asp agc Ser aac Asn atg Met qct Al a 15 gee Al a ace Thr cat His gca Ala gaa Glu gtg Val1 1 tee Ser tea Ser ga e Asp gtg Val1 eca Pro gee Al a ata etg aaa Ile 9g Ala eta Leu att Ile gga Gly eat His gat Asp Lys aa t As n tt t Phe gte Val tee Ser ttc Phe ate Ile gac Asp ttc Phe ggt Gly ace Thr gca Al a gga Gi y gtg Val 115 163 211 259 307 355 403 gcc aat gga Ala Asn Gly gcc aaa agc Ala Lys Ser 120 gga ctt gaa gag Gly Leu Glu Giu 990 Gly 110 ctt caa tcc aat gtg gac aat Leu Gin Ser Asn Val Asp Asn 115 caa ggg gtt ccc Gin Giy Val Pro ttg gaa gtc ggc Leu Giu Val Giy cac atc gat His Ile Asp gtc att Val Ile 135 gac tac tcc ccc Asp Tyr Ser Pro gtt cca gat cct Val Pro Asp Pro ttt tgg aca gac Phe Trp Thr Asp cg Pro 150 gcg cgc atg atc Ala Arg Met Ile gcc Al a 155 gcc acg gaa gtt Ala Thr Giu Val ata Ile 160 gaa got gaa ctg Giu Ala Glu Leu 547 595 643 aaa gaa ctc gat Lys Glu Leu Asp tcc ctg act gaa Ser Leu Thr Glu atc aca caa tca Ile Thr Gin Ser gcc cag Ala Gin 180 cac tac cgt His Tyr Arg ctc agc ggc Leu Ser Gly 200 gaa ctt gtt gcc Giu Leu Val Ala ctt Leu 190 gat gag gaa qtC Asp Glu Giu Val acc gaa ttg Thr Giu Leu 195 aat cac aat Asn His Asn 691 739 gtg gcc cca gaa Val Ala Pro Glu aac As n 205 ogc aag ctg gta Arg Lys Leu Val acc Thr 210 gtt ttt Val Phe 215 gga tao ctg qcc Gly Tyr Leu Ala cgg ttt aac tac Arg Phe Asri Tyr Thr 225 qtc att gao acc Val Ile Asp Thr atc cca ggt gga Ilie Pro Gly Gly aca ttg gcg gcg Thr Leu Ala Ala toa gca tot gac Ser Ala Ser Asp 787 835 883 ast gao atc too Asn Asp Ile Ser acc Thr 250 qcc ato qaa gac Ala Ile Giu Asp aac Asn 255 aat gtt ccc gca Asn Val Pro Ala atc ttc Ile Phe 260 aco gat acc Thr Asp Thr gct ggc att Ala Gly Ile 280 t ca Ser 265 ago oca caa cgg Ser Pro Gin Arg tta Leu 270 gct gaa gtg ttg Ala Glu Val Leu gCC aqc aac Ala Ser Asn 275 tca cto acc Ser Leu Thr gat gtt caa gtg Asp Val Gin Val tcc att ttc acg Ser Ile Phe Thr gat gca Asp Ala 295 gat ggt gaa qoa Asp Gly Giu Ala aco tao ato ago Thr Tyr Ile Ser oaa aaa atc aat Gin Lys Ile Asn 1027 gcc Al a 310 t aa gag ogc att gca ago act ttg toc Glu Arg Ile Ala Ser Thr Leu Ser 315 taaacagtcc taaacagtct 1074 1077 'z210>' 590 <211> 318 <z212> PRT <~213> Corynebacteriun glutamicun <400> 590 Val Ile Leu Lys 1 Ser Ser Asp Val1 Pro Al a Ser Gly His 145 Glu Thr Glu Val Thr 225 Ser Val1 Val1 Ala Leu Ile Gly His Asp As n Giu 130 Phe Al a Gin Val Thr 210 Val Al a Pro Leu Lys Al a Val1 Asp Ser Leu Val1 1.15 His Trp Giu Ser Thr 195 As n Ile Ser Al a Ala As n Phe Val1 Ser Ph e Ile 100 Asp Ile Thr Leu Ala 180 Giu His Asp Asp Ile 260 Ser Asp 5 Phe Gly Thr Ala Gly Val1 Asn Asp Asp Ile 165 Gin Leu As n Thr Leu 245 Phe Asn Ile Phe Asn Asn Arg Lys Ile Thr Thr Asn 55 Asp Val 70 Val Ser Ala Asn Ala Lys Val Ile 135 Pro Ala 150 Lys Glu His Tyr Leu Ser Val Phe 215 Ile Ile 230 Asn Asp Thr Asp Ala Gly Leu Ala 40 Ile Gin Ala Gi y Ser 120 Asp Arg Le u Arg Gly 200 Gly Pro Ile Tb r Ile 280 Leu 25 Cys Leu Val Gin Leu 105 Gin Tyr Met Asp Giu 185 Val1 Tyr Gly Se r Ser 265 Asp Gly 10 Ala Ser Gly Leu Asp 90 Gly Gly Se r Ile Pro 170 Giu Ala Leu Gly Thr 250 S er Val Giu Leu Val Pro Ala Val Asp Val Met Lys 75 Ala Ala Leu Giu Val Pro Pro Gly 140 Ala Ala 155 Ser Leu Leu Val Pro Glu Ala Ser 220 Ser Thr 235 Ala Ile Pro Gin Gin Val Ala Pro Phe Ala Asp Val1 Pro Ala Glu Val 125 Val1 Thr Thr Ala Asn 205 Arg Leu Giu Arg Val1 285 Tb r Gly Ala Val Ala Asp Thr Ser His Asn Ala Met Giu Gly Leu 110 Leu Glu Pro Asp Giu Val Glu Ser 175 Leu Asp 190 Arg Lys Phe Asn Ala Ala Asp Asn 255 Leu Ala 270 Ser Ile Tyr Ile Ser Al a Pro Ile Asp His Gin Val1 Pro Ile 160 Ile Glu Leu Tyr Pro 240 Asn Glu Phe Se r 275 Thr Glu Ser Leu Thr Asp Ala Asp Gly Giu 295 300 Met Gin Lys Ile Asn Ala Giu Arg Ile Ala Ser Thr Leu Ser 305 310 315 <210> <211> <212> <213> <220> <221> <222> <223> 591 1323 DNA Corynebacterium CDS (1300) RXN 00842 glut amicum <400> 591 ccttgtcgcg gaqgtaagcg agggtatttc tggatgtgga acaacqcqga ttatggaaaa tcgtgacttt cataacgttg aqcctactaa ggtttgttcc atg att att caa atc Met Ile Ile Gin Ile cta aga gtg gca Leu Arg Val Ala ttt qcc ttC gtc ggc atc Phe Ala Phe Vai Gly Ile 15 att gtt ggc qcc Ile Val Gly Ala ggt ttC Gly Phe gca tca ggg Ala Ser Gly gga att tgg Gly Ile Trp caa Gin gag gtc atg caa Giu Val Met Gin tat Tyr 30 ttt gtg gcc ttc Phe Val Ala Phe ggc ata gac Gly Ile Asp gtg atq gcg Val Met Ala 211 259 gga gtc att gtt Gly Val Ile Val tct Se r gca gtg atc atg Ala Val Ile Met ttg atc Leu Ile att .ttg cag ctc Ile Leu Gin Leu agc tat ttc aat Ser Tyr Phe Asn gca Ala ggt gaa cac ggt Gly Giu His Gly ga a Giu gtg ttc cgc cga Val Phe Arq Arg gta Val1 75 agt cac ccc gtt Ser His Pro Val ttc Phe 80 tcc aaa att ttg Ser Lys Ile Leu gac Asp atc ggc gtt gtg Ile Gly Val Val acg ttg ttc tcc Thr Leu Phe Ser ggt ttc qtc atq Gly Phe Vai Met ttt gca Phe Ala 100 qc gcg gga Gly Ala Gly qqt tot gtq Gly Ser Val 120 t ca Ser aat ctg aat cag Asn Leu Asn Gin tgg ggq ott cog Trp Gly Leu Pro otc tgg atc Leu Trp Ile 115 atg ttg qac Met Leu Asp atc atq gtt ctt Ile Met Val Leu ct g Le u 125 gtg otg gct qcg Val Leu Ala Ala ggo Gi y 130 gtg gat Vai Asp 135 aaa gta acc aca Lys Val Thr Thr att ggt gca att Ile Gly Ala Ile ccg ttc ato atc Pro Phe Ile Ile att ttc atc act gcc gcc tog ato tao acg ctg gta ggt aat ttc ago Ile Phe Ile Thr Ala Ala Ser Ile Tyr Thr Leu Val Gly Asn Phe Ser 155 160 tca gtg gag cag Ser Val Glu Gin gat tct gct gct Asp Ser Ala Ala gaa gtc gqc acg Giu Val Giy Thr acg ttg Thr Leu 180 cct cac tg Pro His Trp gtt gcg gtg Val Ala Vai 200 gtt gca gcg gtg Vai Ala Ala Val aac As n 190 tat qtg gga ttc Tyr Val Gly Phe aac ctg atg Asn Leu Met 195 ttt aac ccg Phe Asn Pro 691 739 tcc atg gct gtg Ser Met Ala Val att. ggt gga tca Ile Gly Gly Ser cgg gtc Arg Val 215 gca qqt cgg ggc Ala Gly Arg Gly ttg ctq ggc qga Leu Leu Gly Gly ttq Leu 225 atc ctgqgga ttc Ile Leu Gly Phe atc atc atc agt Ile Ile Ile Ser gcg Ala 235 cta aca ctq ttc Leu Thr Leu Phe acc qtg qaa gaa Thr Val Giu Glu 787 835 883 ggc caa gat gat Gly Gin Asp Asp cct atg ctg acg Pro Met Leu Thr atc aac aat ttg Ile Asn Asn Leu aac ccg Asn Pro 260 ctg gct ggc Leu Ala Gly acg gca ctg Thr Ala Leu 280 gta atg gca gtg Val Met Ala Val atc tac gga atg Ile Tyr Gly Met atc ttc aac Ile Phe Asn 275 act gcg aaa Thr Ala Lys ggt atg ttc tac Gly Met Phe Tyr g ca Ala 285 ttg ggc cgt cgt Leu Gly Arg Arg ctc Leu 290 aac cca Asn Pro 295 cag cga ttc cgt Gin Arg Phe Arg ccg Pro 300 gtt tat gtg qtc Val Tyr Val Val gtg ctg att gqt Val Leu Ile Gly gtg ttg agc ttt Val Leu Ser Phe cjga ttc aag aac Gly Phe Lys Asn gtg ggc tat gtg Val Gly Tyr Val 1027 1075 1123 cca gtc ttg gga Pro Val Leu Gly tac Tyr 330 att ggc ctg ctg Ile Gly Leu Leu ctg Le u 335 att gca gtg atg Ile Ala Val Met atg gtg Met Val 340 gcg tqg gtq Ala Trp Val atg cgg atc Met Arg Ile 360 gqa cgc gta cgc Gly Arg Val Arg atc Ile 350 tac aag gaa tcc Tyr Lys Giu Ser gaa cgc cgc Giu Arq Arg 355 gcg ttg agt Ala Leu Ser gca gac ttg ttg Ala Asp Leu Leu atc ggc cat gac Ile Gly His Asp 1171 1219 1267 gga gca Gly Ala 375 gag ctg gcg gtg Giu Leu Ala Val aac cag qaa atc Asn Gin Glu Ile ca a Gin 385 gat tca aac ttg Asp Ser Asn Leu ga t Asp 390 gag gaa caa att Glu Giu Gin Ile aaa Lys 395 gca gcg gtt agg Ala Ala Val Arg aag Lys 400 tagttactct gcagggacqa 1320 gct <210> 592 <211> 400 <212> PRT (213>'Corynebacterium giutamicum 1323 (j <400> 592 Met Ile Ile Gin Ile Leu 1 Val1 Ala Met Al a Se r Ph e Le u Al a Thr 145 Val1 Val1 Gly Ser Le u 225 Thr Asn Gly Phe Ser Gly L ys Val1 Pro Gly 130 Pro Gly Gly Phe Met 210 Ile Val Asn Ala Gly Val1 Giu Ile Met Le u 115 Met Phe As n Thr Asn 195 Phe Le u Gi u Le u Gly Ile Met His Leu Phe 100 T rp Le u Ile Phe Thr 180 Leu As n Gly Giu Asn 260 5 Phe Asp Al a Gi y Asp Al a Ile Asp Ile Ser 165 Leu Met Pro Phe Val1 245 Pro Ala Gi y Leu Giu 70 Ile Gi y Gly Val1 Ile 150 Ser Pro Val Arg Le u 230 Gly Leu Arg Ser Ile Ile 55 Val1 Gly Ala Ser Asp 135 Phe Val1 His Ala Val 215 Ile Gin Ala Val Ala Phe 10 Gly Gin Glu 25 Trp Giy Vai 40 Ile Leu Gin Phe Arg Arg Val Val Val 90 Gly Ser Asn 105 Val Ile Met 120 Lys Val Thr Ile Thr Ala Giu Gin Leu 170 Trp Aia Val 185 Val Ser Met 200 Ala Gly Arg Ile Ile Ser Asp Asp Met 250 Gly Gin Val 265 Al a Val1 Ile Leu ValI 75 Thr Leu Vali Thr Al a 155 Asp Ala Ala Gly Ala 235 Pro Met Ph e Met Val1 Gly Ser Leu As n Leu Val1 140 Ser Ser Ala ValI Gly 220 Leu Met Al a Val1 Gin Se r Se r His Phe Gin Le u 125 Ile Ile Ala Val1 Val1 205 Le u Tb r Le u Val1 Gly T yr Ala T yr Pro Ser Gin 110 Val1 Giy Tyr Ala Asn 190 Ile Leu Leu Thr Val1 270 Ile Phe Val Phe Val1 Thr Trp Le u Ala Thr Le u 175 Tyr Gly Gly Phe Ile 255 Ile Ile Val1 Ile Asn Phe Gi y Gi y Ala Ile Le u 160 Gi u Val1 Giy Gly Al a 240 Ile Tyr Gly Arg Thr 305 Val1 Ala Giu Asp Gin 385 Met Le u 290 Val Giy Val1 Ser Gly 370 Asp Ile 275 Thr Leu Tyr Met Giu 355 Ala Se r Phe Ala Ile Val1 Met 340 Arg Leu Asn Asn Lys Gly T yr 325 Val Arg Ser Leu Leu 280 Gin Leu Leu Val1 Ile 360 Glu Glu Gly Arg Ser Gly Arg 345 Ala Leu Gin Met Phe Phe Tyr 330 Gly Asp Al a Ile Phe Arg Val1 315 Ile Arg Leu Val1 Lys 395 Leu T yr Lys Leu I le 350 Ile Gin Val1 Gly ValI As n Leu 335 Tyr Gly Giu Arg <210> 593 <211> 1323 <212> DNA <213> Corynebacterium glutamicum <220> <221> CDS <222> (101)..(1300) <223> FRXA00842 <400> 593 ccttgtcgcg gaggtaageg agggtatttc tcgtgacttt cataacgttg agcctactaa tggatgtqga ggtttgttcc cta Leu gca Ala gga Gly t tg Leu aga Arg tea Ser att Ile atc Ile gt g Val1 9gg Gly t gg Trp att Ile tte Phe atg Met gtt Val gga Gly 60 gte Val1 eaa Gin t ct Ser 45 agc Se r ate Ile ttt Ph e gt g Val ttc Phe att Ile gtg Val1 ate Ile aat Asn acaacgcgga ttatggaaaa atg att att caa ate Met Ile Ile Gin Ile 1 gtt ggc gee ggt ttc Vai Gly Ala Gly Phe gcc tte gqc ata gae Aia Phe Giy Ile Asp atg tcq gtg atg gcg Met Ser Val Met Ala gca ggt gaa cac ggt Ala Gly Giu His Gly 115 163 211 259 307 gaa Glu gtg ttc cgc cga Val Phe Arg Arg agt cac ccc gtt Ser His Pro Val tcc aaa att ttg Ser Lys Ile Leu ga c Asp atc ggc gtt gtg Ile Gly Val Val gtg Val1 acg ttg ttc: tcc Thr Leu Phe Ser acc Thr 95 qgt ttc gtc atg Gly Phe Val Met ttt gca Phe Ala 100 ggc gcg gga Gly Ala Gly ggt tct gtg Gly Ser Val 120 aat ctg aat cag Asn Leu Asn Gin tgg ggg ctt ccg Trp Gly Leu Pro ctc tgg atc Leu Trp Ile 115 atg ttg gac Met Leu Aso atc atg gtt ctt Ile Met Val Leu gtg ctg gct gcg Val Leu Ala Ala ggc Gly 130 gtg gat Val Asp 135 aaa gta acc aca Lys Val Thr Thr gtc Val1 140 att ggt qca att Ile Gly Ala Ile act ccg ttc atc Thr Pro Phe Ile 145 gta ggt aat ttc Val Gly Asn Phe at c Ile agc Ser 165 ttc atc act gcc Phe Ilie Thr Ala tcg atc: tac acg Ser Ilie Tyr Thr tca gtg gag cag Ser Val Giu Gin ctt Leu 170 gat tct gct gct Asp Ser Ala Ala tta Le u 175 gaa gtc ggc acg Giu Val Gly Thr acg ttg Thr Leu 180 cct cac tgg Pro His Trp gtt gcg gtg Val Ala Vai 200 gtt gca gcg gtq Val Ala Ala Val tat qtg gga ttc Tyr Val Gly Phe aac ctg atg Asn Leu Met 195 ttt aac ccg Phe Asn Pro 691 739 tcc atg gct gtg Ser Met Ala Val att ggt gga tca Ile Gly Gly Ser atg Met 210 cgg gtc Arg Val 215 gca ggt cgg gqc Ala Gly Arg Gly ttg ctg ggc gga Leu Leu Gly Gly ttg Leu 225 atc ctg gga ttc Ile Leu Giy Phe ttg Leu 230 atc atc atc agt Ile Ilie Ile Ser gcg Ala 235 cta aca ctg ttc Leu Thr Leu Phe gcc Ala 240 acc gtg gee gaa Thr Val Giu Glu ggc caa get gat Gly Gin Asp Asp cct atg ctg ecg Pro Met Leu Thr atc eec aat ttg Ile Asn Asn Leu eac ccg Asn Pro 260 ctg gct ggc Leu Ala Gly acg gca ctg Thr Ala Leu 280 gte atg gca gtg Val Met Ala Val atc tac gga atg Ile Tyr Gly Met atc ttc eac Ile Phe Asn 275 act gcg aaa Thr Ala Lys ggt atq ttc tac Giy Met Phe Tyr gca Al a 285 ttg ggc cgt cgt Leu Gly Arg Arg eac cca Asn Pro 295 cag cga ttc cgt Gin Arg Phe Arg gtt tat gtg gtc Val Tyr Val Val gtg ctg att ggt Val Leu Ile Giy 1027 1075 ttt gtg ttg agc ttt gtg gge ttc aeg eec ttg gtg ggc tat gtg tac Phe Val Leu Ser Phe Val Gly Phe Lys 310 315 cca gtc ttq gga tac att ggc ctg ctg Pro Val Leu Gly Tyr Ile Gly Leu Leu 330 geg tgg gtg agg gga cgc gta cgc atc Ala Trp Val Arg Gly Arg Val Arg Ile 345 350 atg cgg ate gca gac ttg ttg cag atc Met Arg Ile Ala Asp Leu Leu Gin Ile 360 365 gga gca gag ctg gcg gtg etc aac eag Gly Ala Glu Leu Ala Val Leu Asn Gin 375 380 gat gag gaa caa att aaa gca gcg gtt Asp Giu Giu Gin Ile Lys Ala Ala Val 390 395 get <210> 594 <211> 400 <212> PRT <213> Gorynebacterium giutamicum <400> 594 Met Ile Ile Gin Ile Leu Arg Val Ala As n ctg Leu 335 tac T yr ggc Gly gaa Giu a gg Arg Val Gly Tyr Val Tyr 325 gca gtg atg atg gtg Ala Val Met Met Val 340 gaa tce gaa cqc cgc Glu Ser Giu Arg Arg 355 gac gga gcg ttg agt Asp Gly Ala Leu Ser 370 caa gat tea aae ttg Gin Asp Ser Asn Leu 385 tagttaetet gcagggacga 1123 1171 1219 1267 1320 1323 1 Val Al a Met Al a Ser Phe Leu Ala Thr 145 Gly Phe Ser Gly Lys Val1 Pro Gly 130 Pro Ala Gly Val1 Giu Ile Met Lou 115 Met Phe Gly Ile Met His Leu Phe 100 Trp Lou Ile 5 Phe Asp Ala Gly Asp Al a Ile Asp Ile Al a Gly Leu Glu 70 Ile Gly Gly Val Ile 150 Ser Ile Ile 55 Val1 Gly Ala Ser Asp 135 Phe Gi y Trp 40 Ile Phe Val1 Giy Val1 120 Lys Ile Phe 10 Giu Val1 Gin Arg Val 90 Asn Met Thr Ala Al a Val1 Ile Le u Val1 75 Thr Leu Val1 Thr Ala 155 Phe Met ValI Cl y Se r Leu Asn Leu Val1 140 Se r Val1 Gin Ser Ser His Phe Gin Lou 125 Ile Ile Gly T yr Al a T yr Pro S er Gin 110 Val Gly T yr Ile Phe Val Phe Val Thr Trp Le u Al a Thr Ile Val1 Ile Asn Ph e Gl y Gl y Ala Ile Lou 160