AU2005339139A1 - Pharmaceutical compositions and methods for treating or preventing oxalate-related disease - Google Patents
Pharmaceutical compositions and methods for treating or preventing oxalate-related disease Download PDFInfo
- Publication number
- AU2005339139A1 AU2005339139A1 AU2005339139A AU2005339139A AU2005339139A1 AU 2005339139 A1 AU2005339139 A1 AU 2005339139A1 AU 2005339139 A AU2005339139 A AU 2005339139A AU 2005339139 A AU2005339139 A AU 2005339139A AU 2005339139 A1 AU2005339139 A1 AU 2005339139A1
- Authority
- AU
- Australia
- Prior art keywords
- oxalate
- composition
- reducing
- bacteria
- delivery vehicle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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| US8486389B2 (en) | 1997-05-23 | 2013-07-16 | Oxthera, Inc. | Compositions and methods for treating or preventing oxalate-related disease |
| AU2005339139A1 (en) * | 2005-12-14 | 2007-06-21 | Oxthera, Inc. | Pharmaceutical compositions and methods for treating or preventing oxalate-related disease |
| JP5558002B2 (ja) | 2005-12-16 | 2014-07-23 | オクセラ インコーポレイテッド | シュウ酸塩低減化のための組成物および方法 |
| DK2046373T3 (da) | 2006-08-02 | 2013-05-27 | Althea Technologies Inc | Krystalliseret oxalatdecarboxylase og fremgangsmåder til anvendelse |
| GB2463181B (en) | 2007-05-14 | 2013-03-27 | Univ New York State Res Found | Induction of a physiological dispersion response in bacterial cells in a biofilm |
| US9283252B2 (en) | 2008-09-30 | 2016-03-15 | Meiji Co., Ltd. | Lactic acid bacterium having high oxalic acid decomposition ability |
| FR2936952A1 (fr) * | 2008-10-09 | 2010-04-16 | Monique Bellec | Administration par voie orale de medicaments et complements nutritionnels |
| DK2270138T3 (en) | 2009-07-02 | 2018-06-25 | Oxthera Intellectual Property Ab | Purification and isolation of recombinant oxalate-degrading enzymes |
| ES2617917T3 (es) * | 2009-07-02 | 2017-06-20 | Oxthera Intellectual Property Ab | Purificación y aislamiento de enzimas de degradación de oxalato recombinantes y partículas secadas por atomización que contienen enzimas de degradación de oxalato |
| US8431122B2 (en) | 2009-07-02 | 2013-04-30 | Oxthera Intellectual Property Ab | Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes |
| US20110070334A1 (en) * | 2009-09-20 | 2011-03-24 | Nagendra Rangavajla | Probiotic Stabilization |
| WO2011066282A2 (en) * | 2009-11-25 | 2011-06-03 | Captozyme, Llc | Methods and compositions for treating oxalate-related conditions |
| HK1253538A1 (en) * | 2010-08-04 | 2019-06-21 | Thomas Julius Borody | Compositions for fecal floral transplantation and methods for making and using them |
| BR112013002667B1 (pt) * | 2010-08-04 | 2020-02-04 | Thomas Julius Borody | composições para transplante da flora intestinal e métodos para fazê-las e usá-las e dispositivos para administrá-las |
| US20140112985A1 (en) * | 2012-10-22 | 2014-04-24 | Polonez Therapeutics Llc | Method of prevention and treatment of clostridium difficile infection |
| WO2014113648A1 (en) | 2013-01-18 | 2014-07-24 | Allena Pharmaceuticals, Inc. | Crystallized oxalate decarboxylase and methods of use |
| US11077238B2 (en) | 2013-06-07 | 2021-08-03 | Allena Pharmaceuticals, Inc. | Compositions, methods, and devices for dialysis |
| WO2015002588A1 (en) | 2013-07-05 | 2015-01-08 | Oxthera Intellectual Property Ab | Secretagogues derived from oxalobacter formigenes |
| PT3087178T (pt) * | 2013-12-23 | 2018-11-21 | Nexttobe Ab | Método para produzir oxalato oxidases que têm atividade ótica próxima ao ph fisiológico e utilização de tais oxalato oxidases recombinantes no tratamento de doenças relacionadas com oxalato |
| EP3164145A4 (en) | 2014-07-01 | 2018-01-17 | Probi Usa, Inc. | Bi-layer dual release probiotic tablets |
| AU2016244121B2 (en) | 2015-04-02 | 2020-11-05 | Orenzymes Llc | High efficiency oxalate-degrading enzymes for degradation of insoluble and soluble oxalate |
| FR3045384B1 (fr) * | 2015-12-18 | 2020-02-07 | Institut National De La Recherche Agronomique | Composition lyophilisee pour la conservation de microbiote dans son ecosysteme |
| CN106974262B (zh) * | 2016-01-15 | 2021-05-25 | 深圳华大生命科学研究院 | 肠道益生杆菌在治疗和预防肥胖及其相关疾病中的应用 |
| EP3426263A4 (en) * | 2016-03-09 | 2019-10-16 | Incube Labs, LLC | METHOD AND ARTICLE FOR THE DELIVERY OF LIVABLE CELLS IN SOLID TISSUE |
| CA3023042A1 (en) * | 2016-06-13 | 2017-12-21 | Oxthera Intellectual Property Ab | Compositions and methods for the treatment or prevention of oxalate-related disorders |
| WO2018218159A1 (en) | 2017-05-26 | 2018-11-29 | Crestovo Holdings Llc | Lyophilized compositions comprising fecal microbe-based therapeutic agents and methods for making and using same |
| HUE069333T2 (hu) | 2017-11-17 | 2025-02-28 | Evonik Operations Gmbh | Eljárás bevonatos kemény héjú kapszula elõállítására |
| CN110734861B (zh) * | 2018-07-20 | 2022-02-11 | 中国农业大学 | 一种猪肠道食糜微生物组的体外保藏方法 |
| JP2020055755A (ja) * | 2018-09-28 | 2020-04-09 | 日本ケミファ株式会社 | 腸溶性製剤 |
| WO2020071994A1 (en) * | 2018-10-04 | 2020-04-09 | Oxthera Intellectual Property Ab | New medical use of oxalate-reducing bacteria |
| EP3646857A1 (en) * | 2018-11-01 | 2020-05-06 | Evonik Operations GmbH | Colonic delivery system for microorganisms |
| CN109402022A (zh) * | 2018-12-05 | 2019-03-01 | 上海上药信谊药厂有限公司 | 一种产甲酸草酸杆菌及其应用 |
| US20230092431A1 (en) * | 2020-01-14 | 2023-03-23 | Synlogic Operating Company, Inc. | Bacteria engineered to treat disorders in which oxalate is detrimental |
| US20230107049A1 (en) * | 2020-02-28 | 2023-04-06 | The Cleveland Clinic Foundation | Analysis of microbiome for diagnosis and treating of urinary stone disease |
| EP4117694A4 (en) * | 2020-03-10 | 2024-06-05 | Federation Bio Inc. | MICROBIAL CONSORTIUMS FOR DISEASE TREATMENT |
| WO2022103634A1 (en) | 2020-11-16 | 2022-05-19 | Orcosa Inc. | Improved use of cannabinoids in the treatment of epilepsy |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| EP4329785A1 (en) * | 2021-04-30 | 2024-03-06 | Arranta Bio Holdings, LLC | Compositions for preserving anaerobic microorganisms and methods of making and using the same |
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| DE3030185A1 (de) | 1980-08-07 | 1982-04-08 | Kohlbecker, Günther, 3000 Hannover | Verfahren zur enzymatischen entfernung von oxalat mittels oxalat-oxidase |
| DE3204284A1 (de) | 1982-02-06 | 1983-08-18 | Kohlbecker, Günther, 3000 Hannover | Verfahren zur enzymatischen entfernung von sauerstoff |
| JPS5968344A (ja) * | 1982-10-12 | 1984-04-18 | Agency Of Ind Science & Technol | 非対称機能膜及びその製法 |
| US4539118A (en) * | 1984-03-23 | 1985-09-03 | Sigma Chemical Company | Rapid, accurate method of separation of oxalate from urine and other biological fluids |
| US5263992A (en) * | 1986-10-17 | 1993-11-23 | Bio-Metric Systems, Inc. | Biocompatible device with covalently bonded biocompatible agent |
| US5427935A (en) * | 1987-07-24 | 1995-06-27 | The Regents Of The University Of Michigan | Hybrid membrane bead and process for encapsulating materials in semi-permeable hybrid membranes |
| US5206219A (en) * | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
| US5286495A (en) * | 1992-05-11 | 1994-02-15 | University Of Florida | Process for microencapsulating cells |
| EP0673416A1 (en) * | 1992-11-30 | 1995-09-27 | Zeneca Limited | Oxalate decarboxylase |
| FI954911A0 (fi) * | 1993-04-16 | 1995-10-16 | Mccormick & Co Inc | Kapselointikoostumukset |
| US5788687A (en) * | 1994-02-01 | 1998-08-04 | Caphco, Inc | Compositions and devices for controlled release of active ingredients |
| US5554147A (en) * | 1994-02-01 | 1996-09-10 | Caphco, Inc. | Compositions and devices for controlled release of active ingredients |
| US5505713A (en) * | 1994-04-01 | 1996-04-09 | Minimed Inc. | Indwelling catheter with stable enzyme coating |
| JPH10500019A (ja) | 1994-05-18 | 1998-01-06 | ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド | ヒトのオキサリル−CoAデカルボキシラーゼ |
| US6214980B1 (en) * | 1994-06-20 | 2001-04-10 | University Of Florida | Materials and methods for detection of Oxalobacte formigenes |
| US6090628A (en) | 1994-06-20 | 2000-07-18 | University Of Florida | Materials and methods for detection of Oxalobactor formigenes |
| US5604111A (en) * | 1994-06-20 | 1997-02-18 | University Of Florida Research Foundation | Method and kit for detection of oxalate |
| US5912125A (en) * | 1994-06-20 | 1999-06-15 | University Of Florida | Materials and methods for detection of oxalobacter |
| US6033719A (en) * | 1996-04-25 | 2000-03-07 | Medtronic, Inc. | Method for covalent attachment of biomolecules to surfaces of medical devices |
| SE9603029D0 (sv) | 1996-08-20 | 1996-08-20 | Svenska Traeforskningsinst | Method for lowering the level of oxalic acid |
| US6297425B1 (en) * | 1997-03-21 | 2001-10-02 | Pioneer Hi-Bred International, Inc. | Gene encoding oxalate decarboxylase from aspergillus phoenices |
| DE69841200D1 (de) * | 1997-05-23 | 2009-11-12 | Oxthera Inc | Oxalate-abbauende mikroorganismen oder oxalate-abbauende enzyme zur verhütung der oxalate-verwandten krankheiten |
| US8486389B2 (en) * | 1997-05-23 | 2013-07-16 | Oxthera, Inc. | Compositions and methods for treating or preventing oxalate-related disease |
| US20040120941A1 (en) * | 1997-05-23 | 2004-06-24 | Allison Milton J. | Materials and methods for treating or preventing oxalate-related disease |
| US6355242B1 (en) * | 1997-05-23 | 2002-03-12 | Ixion Biotechnology, Inc. | Materials and methods for treating or preventing oxalate-related disease |
| US6161499A (en) * | 1997-07-07 | 2000-12-19 | Cvd Diamond Corporation | Apparatus and method for nucleation and deposition of diamond using hot-filament DC plasma |
| US6080404A (en) * | 1997-09-05 | 2000-06-27 | University Of Florida | Materials and methods for removal of substances from fluids |
| US6566407B2 (en) * | 1997-11-05 | 2003-05-20 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
| US5985938A (en) * | 1997-11-05 | 1999-11-16 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
| US6203797B1 (en) * | 1998-01-06 | 2001-03-20 | Stephen C. Perry | Dietary supplement and method for use as a probiotic, for alleviating the symptons associated with irritable bowel syndrome |
| MXPA01003197A (es) * | 1998-09-28 | 2004-04-21 | Warner Lambert Co | Suministro enterico y colonico utilizando capsulas de chpm. |
| IT1309427B1 (it) | 1999-05-28 | 2002-01-23 | Mendes S U R L | Composizione dietetica o farmaceutica utile per la prevenzione o iltrattamento dell'iperossaluria e suo uso |
| HK1046098A1 (zh) | 1999-06-07 | 2002-12-27 | 南诺斯菲尔股份有限公司 | 包被颗粒的方法以及所得颗粒 |
| DE10026541A1 (de) * | 2000-05-27 | 2001-11-29 | Zeiss Carl | Vorrichtung zur präzisen Positionierung eines Bauteils, insbesondere eines optischen Bauteiles |
| AU2001284427A1 (en) | 2000-09-07 | 2002-03-22 | Shingo Tomoda | Analog electronic drum set, parts for drum stick, analog electronic drum set andfoot-pedal unit |
| ATE391509T1 (de) | 2000-12-18 | 2008-04-15 | Probio Health | Von lactobacillus casei ke01 stamm abgeleitete probiotische verbindungen |
| US7407668B2 (en) * | 2002-01-24 | 2008-08-05 | Boston Scimed, Inc. | Medical articles having enzymatic surfaces for localized therapy |
| US6929940B1 (en) * | 2002-08-20 | 2005-08-16 | University Of Florida Research Foundation, Inc. | Polynucleotides encoding oxalate decarboxylase from Aspergillus niger and methods of use |
| US20050100559A1 (en) * | 2003-11-07 | 2005-05-12 | The Procter & Gamble Company | Stabilized compositions comprising a probiotic |
| WO2005060937A1 (en) * | 2003-12-23 | 2005-07-07 | Chr. Hansen A/S | Compressed tablets comprising viable probiotic microorganisms |
| AU2005339139A1 (en) * | 2005-12-14 | 2007-06-21 | Oxthera, Inc. | Pharmaceutical compositions and methods for treating or preventing oxalate-related disease |
-
2005
- 2005-12-14 AU AU2005339139A patent/AU2005339139A1/en not_active Abandoned
- 2005-12-14 PT PT58542200T patent/PT1962873E/pt unknown
- 2005-12-14 JP JP2008545553A patent/JP5047190B2/ja not_active Expired - Fee Related
- 2005-12-14 DK DK05854220.0T patent/DK1962873T3/da active
- 2005-12-14 ES ES05854220T patent/ES2426258T3/es not_active Expired - Lifetime
- 2005-12-14 EP EP05854220.0A patent/EP1962873B1/en not_active Expired - Lifetime
- 2005-12-14 SI SI200531760T patent/SI1962873T1/sl unknown
- 2005-12-14 CA CA002645871A patent/CA2645871A1/en active Pending
- 2005-12-14 PL PL05854220T patent/PL1962873T3/pl unknown
- 2005-12-14 US US12/086,551 patent/US20100028422A1/en not_active Abandoned
- 2005-12-14 WO PCT/US2005/045457 patent/WO2007070052A2/en not_active Ceased
-
2006
- 2006-12-14 ES ES06848618.2T patent/ES2628090T3/es active Active
- 2006-12-14 WO PCT/US2006/047909 patent/WO2007070677A2/en not_active Ceased
- 2006-12-14 PL PL06848618T patent/PL1965816T3/pl unknown
- 2006-12-14 AU AU2006326016A patent/AU2006326016B2/en not_active Ceased
- 2006-12-14 JP JP2008545843A patent/JP5203217B2/ja not_active Expired - Fee Related
- 2006-12-14 LT LTEP06848618.2T patent/LT1965816T/lt unknown
- 2006-12-14 CA CA2650122A patent/CA2650122C/en active Active
- 2006-12-14 EP EP06848618.2A patent/EP1965816B1/en not_active Not-in-force
- 2006-12-14 US US11/639,388 patent/US8545836B2/en not_active Expired - Fee Related
- 2006-12-14 HU HUE06848618A patent/HUE034539T2/en unknown
-
2013
- 2013-08-28 CY CY20131100733T patent/CY1114397T1/el unknown
-
2017
- 2017-06-07 CY CY20171100595T patent/CY1118936T1/el unknown
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