AU2005333518B2 - Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators - Google Patents
Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators Download PDFInfo
- Publication number
- AU2005333518B2 AU2005333518B2 AU2005333518A AU2005333518A AU2005333518B2 AU 2005333518 B2 AU2005333518 B2 AU 2005333518B2 AU 2005333518 A AU2005333518 A AU 2005333518A AU 2005333518 A AU2005333518 A AU 2005333518A AU 2005333518 B2 AU2005333518 B2 AU 2005333518B2
- Authority
- AU
- Australia
- Prior art keywords
- methyl
- pyrrole
- hexahydroindeno
- mmol
- observed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 title description 6
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 title description 6
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- 239000000203 mixture Substances 0.000 claims description 33
- 125000003118 aryl group Chemical group 0.000 claims description 30
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 25
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 24
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- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical group C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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- PVFOMCVHYWHZJE-UHFFFAOYSA-N trichloroacetyl chloride Chemical compound ClC(=O)C(Cl)(Cl)Cl PVFOMCVHYWHZJE-UHFFFAOYSA-N 0.000 description 1
- 125000006168 tricyclic group Chemical group 0.000 description 1
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- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59204704P | 2004-07-29 | 2004-07-29 | |
| US60/592,047 | 2004-07-29 | ||
| PCT/US2005/026415 WO2007081299A2 (en) | 2004-07-29 | 2005-07-26 | Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2005333518A1 AU2005333518A1 (en) | 2007-02-22 |
| AU2005333518A8 AU2005333518A8 (en) | 2008-08-07 |
| AU2005333518B2 true AU2005333518B2 (en) | 2010-12-02 |
Family
ID=37075566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005333518A Ceased AU2005333518B2 (en) | 2004-07-29 | 2005-07-26 | Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US20060025601A1 (enExample) |
| EP (1) | EP1841738A4 (enExample) |
| JP (1) | JP4990164B2 (enExample) |
| KR (2) | KR20130047765A (enExample) |
| CN (1) | CN101516372A (enExample) |
| AR (1) | AR050274A1 (enExample) |
| AU (1) | AU2005333518B2 (enExample) |
| BR (1) | BRPI0512869A (enExample) |
| CA (1) | CA2603249C (enExample) |
| IL (1) | IL180977A (enExample) |
| NO (1) | NO20071102L (enExample) |
| NZ (1) | NZ552806A (enExample) |
| RU (1) | RU2007107494A (enExample) |
| TW (1) | TWI377195B (enExample) |
| WO (1) | WO2007081299A2 (enExample) |
| ZA (1) | ZA200700684B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005333518B2 (en) * | 2004-07-29 | 2010-12-02 | Athersys, Inc. | Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators |
| JP5528699B2 (ja) | 2006-05-16 | 2014-06-25 | 武田薬品工業株式会社 | 縮合複素環化合物およびその用途 |
| EP1988091B1 (en) | 2007-02-07 | 2015-06-10 | Kyowa Hakko Kirin Co., Ltd. | Tricyclic compounds |
| JP5520051B2 (ja) | 2007-11-15 | 2014-06-11 | 武田薬品工業株式会社 | 縮合ピリジン誘導体およびその用途 |
| EP2242745A1 (de) * | 2008-02-07 | 2010-10-27 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP3081213B1 (en) | 2008-08-06 | 2020-04-01 | Kyowa Kirin Co., Ltd. | Tricyclic compound |
| TW201041851A (en) | 2009-03-10 | 2010-12-01 | Organon Nv | Tricyclic heterocyclic derivatives |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| CN106380440B (zh) * | 2016-08-30 | 2019-02-01 | 华东师范大学 | 一种茚酮并吡咯类衍生物及其合成方法和应用 |
| CN106631989B (zh) * | 2016-11-26 | 2019-07-16 | 威海迪素制药有限公司 | 一种盐酸多奈哌齐有关物质e的制备方法 |
| EP3733204A4 (en) | 2017-12-27 | 2021-09-15 | Takeda Pharmaceutical Company Limited | THERAPEUTIC AGENT FOR URINARY INCONTINENCE OF STRESS AND FECAL INCONTINENCE |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0170093A1 (en) * | 1984-07-25 | 1986-02-05 | Abbott Laboratories | 1,2,3,3a,8,8a-Hexahydro-Indeno-(1,2-c)Pyrrdes |
| US4622405A (en) * | 1984-07-25 | 1986-11-11 | Abbott Laboratories | 1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles useful in the treatment of hypertension |
| WO1990006927A1 (en) * | 1988-12-15 | 1990-06-28 | Abbott Laboratories | 5-ht selective agents |
| US5049564A (en) * | 1989-11-17 | 1991-09-17 | Abbott Laboratories | 5-HT selective agents |
| US5244888A (en) * | 1989-11-17 | 1993-09-14 | Abbott Laboratories | 5-HT selective agents |
| US5646173A (en) * | 1993-10-22 | 1997-07-08 | Hoffmann-La Roche Inc. | Tricyclic pyrrole derivatives useful as 5-HT selective agents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7351711B2 (en) * | 2003-07-31 | 2008-04-01 | Janssen Pharmaceutical, N.V. | Tricyclic indanyls as integrin inhibitors |
| TWI350168B (en) * | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| AU2005333518B2 (en) * | 2004-07-29 | 2010-12-02 | Athersys, Inc. | Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators |
-
2005
- 2005-07-26 AU AU2005333518A patent/AU2005333518B2/en not_active Ceased
- 2005-07-26 BR BRPI0512869-2A patent/BRPI0512869A/pt not_active Application Discontinuation
- 2005-07-26 RU RU2007107494/04A patent/RU2007107494A/ru not_active Application Discontinuation
- 2005-07-26 KR KR1020137007788A patent/KR20130047765A/ko not_active Withdrawn
- 2005-07-26 WO PCT/US2005/026415 patent/WO2007081299A2/en not_active Ceased
- 2005-07-26 EP EP05858534A patent/EP1841738A4/en not_active Withdrawn
- 2005-07-26 CA CA2603249A patent/CA2603249C/en not_active Expired - Fee Related
- 2005-07-26 JP JP2007554065A patent/JP4990164B2/ja not_active Expired - Fee Related
- 2005-07-26 KR KR1020077002230A patent/KR101257233B1/ko not_active Expired - Fee Related
- 2005-07-26 US US11/189,952 patent/US20060025601A1/en not_active Abandoned
- 2005-07-26 CN CNA2005800255071A patent/CN101516372A/zh active Pending
- 2005-07-26 NZ NZ552806A patent/NZ552806A/en not_active IP Right Cessation
- 2005-07-28 AR ARP050103146A patent/AR050274A1/es not_active Application Discontinuation
- 2005-07-29 TW TW094125988A patent/TWI377195B/zh not_active IP Right Cessation
-
2007
- 2007-01-24 ZA ZA200700684A patent/ZA200700684B/xx unknown
- 2007-01-25 IL IL180977A patent/IL180977A/en not_active IP Right Cessation
- 2007-02-27 NO NO20071102A patent/NO20071102L/no not_active Application Discontinuation
-
2009
- 2009-06-04 US US12/478,362 patent/US7935830B2/en not_active Expired - Fee Related
-
2011
- 2011-03-25 US US13/071,732 patent/US8232311B2/en not_active Expired - Fee Related
-
2012
- 2012-06-18 US US13/526,249 patent/US8716324B2/en not_active Expired - Fee Related
-
2014
- 2014-03-21 US US14/221,809 patent/US9096520B2/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0170093A1 (en) * | 1984-07-25 | 1986-02-05 | Abbott Laboratories | 1,2,3,3a,8,8a-Hexahydro-Indeno-(1,2-c)Pyrrdes |
| US4622405A (en) * | 1984-07-25 | 1986-11-11 | Abbott Laboratories | 1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles useful in the treatment of hypertension |
| WO1990006927A1 (en) * | 1988-12-15 | 1990-06-28 | Abbott Laboratories | 5-ht selective agents |
| US5049564A (en) * | 1989-11-17 | 1991-09-17 | Abbott Laboratories | 5-HT selective agents |
| US5244888A (en) * | 1989-11-17 | 1993-09-14 | Abbott Laboratories | 5-HT selective agents |
| US5646173A (en) * | 1993-10-22 | 1997-07-08 | Hoffmann-La Roche Inc. | Tricyclic pyrrole derivatives useful as 5-HT selective agents |
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| Title |
|---|
| D6: LAHIRI S C ET AL., JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 57, no. 6, 1 June 1968, pages 1013-1016, XP002056178, ISSN: 0022-3549 * |
| D7: LUCID K ET AL., HETEROCYCLES, vol. 62, 7 November 2003, pages 543-557, XP002305186, ISSN: 0385-5414 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20120252859A1 (en) | 2012-10-04 |
| US20140206739A1 (en) | 2014-07-24 |
| US8716324B2 (en) | 2014-05-06 |
| TW200619196A (en) | 2006-06-16 |
| WO2007081299A2 (en) | 2007-07-19 |
| JP2008508365A (ja) | 2008-03-21 |
| US20090239925A1 (en) | 2009-09-24 |
| KR20080025657A (ko) | 2008-03-21 |
| EP1841738A2 (en) | 2007-10-10 |
| KR20130047765A (ko) | 2013-05-08 |
| IL180977A (en) | 2012-08-30 |
| NZ552806A (en) | 2009-09-25 |
| US8232311B2 (en) | 2012-07-31 |
| AU2005333518A8 (en) | 2008-08-07 |
| TWI377195B (en) | 2012-11-21 |
| CA2603249A1 (en) | 2007-07-19 |
| RU2007107494A (ru) | 2008-09-10 |
| BRPI0512869A (pt) | 2008-04-08 |
| US20060025601A1 (en) | 2006-02-02 |
| AU2005333518A1 (en) | 2007-02-22 |
| WO2007081299A3 (en) | 2007-09-20 |
| US9096520B2 (en) | 2015-08-04 |
| CA2603249C (en) | 2014-01-21 |
| KR101257233B1 (ko) | 2013-04-29 |
| US20110172283A1 (en) | 2011-07-14 |
| IL180977A0 (en) | 2009-02-11 |
| US7935830B2 (en) | 2011-05-03 |
| EP1841738A4 (en) | 2010-06-02 |
| NO20071102L (no) | 2007-04-20 |
| JP4990164B2 (ja) | 2012-08-01 |
| ZA200700684B (en) | 2008-10-29 |
| CN101516372A (zh) | 2009-08-26 |
| AR050274A1 (es) | 2006-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND PRIORITY DETAILS FROM 60/592,047 29 JUN 2004 US TO 60/592,047 29 JUL 2004 US |
|
| TH | Corrigenda |
Free format text: IN VOL 21, NO 8, PAGE(S) 850 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE -NAME INDEX UNDER THE NAME ATHERSYS, INC., APPLICATION NO. 2005333518, UNDER INID(43), CORRECT THE DATE TO READ 19.07.07 Free format text: IN VOL 21, NO 8, PAGE(S) 831 UNDER THE HEADING APPLICATIONS OPI NAME INDEX UNDER THE NAME ATHERSYS, INC., APPLICATION NO. 2005333518, UNDER INID(43), CORRECT THE DATE TO READ 19.07.07 |
|
| TH | Corrigenda |
Free format text: IN VOL 21, NO 8, PAGE(S) 850 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE -NAME INDEX UNDER THE NAME ATHERSYS, INC., APPLICATION NO. 2005333518, UNDER INID(43), CORRECT THE DATE TO READ 19.07.07 Free format text: IN VOL 21, NO 8, PAGE(S) 831 UNDER THE HEADING APPLICATIONS OPI NAME INDEX UNDER THE NAME ATHERSYS, INC., APPLICATION NO. 2005333518, UNDER INID(43), CORRECT THE DATE TO READ 19.07.07 |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |