AU2005316384B2 - RNAi modulation of MLL-AF4 and uses thereof - Google Patents

RNAi modulation of MLL-AF4 and uses thereof Download PDF

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Publication number
AU2005316384B2
AU2005316384B2 AU2005316384A AU2005316384A AU2005316384B2 AU 2005316384 B2 AU2005316384 B2 AU 2005316384B2 AU 2005316384 A AU2005316384 A AU 2005316384A AU 2005316384 A AU2005316384 A AU 2005316384A AU 2005316384 B2 AU2005316384 B2 AU 2005316384B2
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Prior art keywords
irna agent
mll
cell
cells
irna
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AU2005316384A
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AU2005316384A1 (en
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Philipp Hadwiger
Olaf Heidenreich
Hans-Peter Vornlocher
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Inductance-Capacitance Distribution Constants And Capacitance-Resistance Oscillators (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Control Of El Displays (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2005316384A 2004-12-14 2005-12-14 RNAi modulation of MLL-AF4 and uses thereof Expired AU2005316384B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US63593604P 2004-12-14 2004-12-14
US60/635,936 2004-12-14
US66839205P 2005-04-05 2005-04-05
US60/668,392 2005-04-05
US69841405P 2005-07-12 2005-07-12
US60/698,414 2005-07-12
PCT/US2005/045827 WO2006066158A2 (en) 2004-12-14 2005-12-14 Rnai modulation of mll-af4 and uses thereof

Publications (2)

Publication Number Publication Date
AU2005316384A1 AU2005316384A1 (en) 2006-06-22
AU2005316384B2 true AU2005316384B2 (en) 2012-02-09

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AU2005316384A Expired AU2005316384B2 (en) 2004-12-14 2005-12-14 RNAi modulation of MLL-AF4 and uses thereof

Country Status (7)

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US (4) US7361752B2 (enExample)
EP (1) EP1824872B1 (enExample)
JP (2) JP2008523157A (enExample)
AT (1) ATE544774T1 (enExample)
AU (1) AU2005316384B2 (enExample)
CA (1) CA2590768A1 (enExample)
WO (1) WO2006066158A2 (enExample)

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Also Published As

Publication number Publication date
CA2590768A1 (en) 2006-06-22
US7674779B2 (en) 2010-03-09
AU2005316384A1 (en) 2006-06-22
ATE544774T1 (de) 2012-02-15
WO2006066158A3 (en) 2007-04-19
US20080233584A1 (en) 2008-09-25
EP1824872B1 (en) 2012-02-08
US20120010267A1 (en) 2012-01-12
US20100256218A1 (en) 2010-10-07
JP2008523157A (ja) 2008-07-03
US8034793B2 (en) 2011-10-11
JP2011254840A (ja) 2011-12-22
EP1824872A2 (en) 2007-08-29
US7361752B2 (en) 2008-04-22
WO2006066158A2 (en) 2006-06-22
US20060166918A1 (en) 2006-07-27
EP1824872A4 (en) 2008-11-26

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