AU2005315303A1 - Chromane derivatives useful as acid pump antagonists - Google Patents
Chromane derivatives useful as acid pump antagonists Download PDFInfo
- Publication number
- AU2005315303A1 AU2005315303A1 AU2005315303A AU2005315303A AU2005315303A1 AU 2005315303 A1 AU2005315303 A1 AU 2005315303A1 AU 2005315303 A AU2005315303 A AU 2005315303A AU 2005315303 A AU2005315303 A AU 2005315303A AU 2005315303 A1 AU2005315303 A1 AU 2005315303A1
- Authority
- AU
- Australia
- Prior art keywords
- dihydro
- group
- chromen
- alkyl group
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000002253 acid Substances 0.000 title claims description 35
- 239000005557 antagonist Substances 0.000 title description 18
- 125000003016 chromanyl group Chemical class O1C(CCC2=CC=CC=C12)* 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 143
- 125000000217 alkyl group Chemical group 0.000 claims description 59
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 42
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 40
- 238000000034 method Methods 0.000 claims description 39
- 150000003839 salts Chemical class 0.000 claims description 33
- 125000005843 halogen group Chemical group 0.000 claims description 27
- 229910052757 nitrogen Inorganic materials 0.000 claims description 23
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 21
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 21
- 125000001424 substituent group Chemical group 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 18
- 125000003545 alkoxy group Chemical group 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
- 230000002401 inhibitory effect Effects 0.000 claims description 14
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 13
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
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- 229910052731 fluorine Inorganic materials 0.000 claims description 9
- 238000001727 in vivo Methods 0.000 claims description 9
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- 229960001491 trospium Drugs 0.000 description 1
- OYYDSUSKLWTMMQ-JKHIJQBDSA-N trospium Chemical compound [N+]12([C@@H]3CC[C@H]2C[C@H](C3)OC(=O)C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CCCC1 OYYDSUSKLWTMMQ-JKHIJQBDSA-N 0.000 description 1
- JFJZZMVDLULRGK-URLMMPGGSA-O tubocurarine Chemical compound C([C@H]1[N+](C)(C)CCC=2C=C(C(=C(OC3=CC=C(C=C3)C[C@H]3C=4C=C(C(=CC=4CCN3C)OC)O3)C=21)O)OC)C1=CC=C(O)C3=C1 JFJZZMVDLULRGK-URLMMPGGSA-O 0.000 description 1
- 229960001844 tubocurarine Drugs 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 description 1
- FCFNRCROJUBPLU-DNDCDFAISA-N valinomycin Chemical compound CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC1=O FCFNRCROJUBPLU-DNDCDFAISA-N 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 235000016804 zinc Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63696304P | 2004-12-17 | 2004-12-17 | |
| US60/636,963 | 2004-12-17 | ||
| US69577205P | 2005-06-29 | 2005-06-29 | |
| US60/695,772 | 2005-06-29 | ||
| PCT/IB2005/003758 WO2006064339A1 (en) | 2004-12-17 | 2005-12-07 | Chromane derivatives useful as acid pump antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2005315303A1 true AU2005315303A1 (en) | 2006-06-22 |
Family
ID=35995811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005315303A Abandoned AU2005315303A1 (en) | 2004-12-17 | 2005-12-07 | Chromane derivatives useful as acid pump antagonists |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20090291977A1 (enExample) |
| EP (1) | EP1838309B1 (enExample) |
| JP (1) | JP2008524199A (enExample) |
| KR (1) | KR20070086294A (enExample) |
| AP (1) | AP2007004023A0 (enExample) |
| AT (1) | ATE405262T1 (enExample) |
| AU (1) | AU2005315303A1 (enExample) |
| BR (1) | BRPI0519598A2 (enExample) |
| CA (1) | CA2591412A1 (enExample) |
| DE (1) | DE602005009257D1 (enExample) |
| EA (1) | EA011512B1 (enExample) |
| ES (1) | ES2313444T3 (enExample) |
| IL (1) | IL183602A0 (enExample) |
| MA (1) | MA29095B1 (enExample) |
| MX (1) | MX2007007010A (enExample) |
| NO (1) | NO20072764L (enExample) |
| TN (1) | TNSN07227A1 (enExample) |
| WO (1) | WO2006064339A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007026218A2 (en) * | 2005-09-01 | 2007-03-08 | Pfizer Japan Inc. | Chromane substituted 2-alkyl imidazopyridine derivatives and use thereof as acid pump antagonists |
| KR20080108129A (ko) * | 2006-03-17 | 2008-12-11 | 라퀄리아 파마 인코포레이티드 | 크로메인 유도체 |
| WO2008059373A1 (en) * | 2006-11-17 | 2008-05-22 | Raqualia Pharma Inc. | Imidazo [1, 2-a] pyrazine derivatives and their use as acid pump antagonists |
| MX2016006657A (es) | 2013-11-22 | 2016-10-12 | CL BioSciences LLC | Antagonistas de gastrina (por ejemplo, yf476, netazepido) para el tratamiento y prevencion de osteoporosis. |
| JP6315708B2 (ja) * | 2015-06-22 | 2018-04-25 | 日本電信電話株式会社 | リチウム空気二次電池、リチウム空気二次電池の製造方法及びリチウム空気二次電池を備えた装置 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9801526D0 (sv) * | 1998-04-29 | 1998-04-29 | Astra Ab | New compounds |
| SE0102808D0 (sv) * | 2001-08-22 | 2001-08-22 | Astrazeneca Ab | New compounds |
| EA008304B1 (ru) * | 2002-11-19 | 2007-04-27 | Алтана Фарма Аг | 8-замещённые имидазопиридины |
-
2005
- 2005-12-07 WO PCT/IB2005/003758 patent/WO2006064339A1/en not_active Ceased
- 2005-12-07 KR KR1020077013608A patent/KR20070086294A/ko not_active Abandoned
- 2005-12-07 EA EA200701087A patent/EA011512B1/ru not_active IP Right Cessation
- 2005-12-07 US US11/721,453 patent/US20090291977A1/en not_active Abandoned
- 2005-12-07 DE DE602005009257T patent/DE602005009257D1/de not_active Expired - Fee Related
- 2005-12-07 AU AU2005315303A patent/AU2005315303A1/en not_active Abandoned
- 2005-12-07 ES ES05818222T patent/ES2313444T3/es not_active Expired - Lifetime
- 2005-12-07 JP JP2007546218A patent/JP2008524199A/ja active Pending
- 2005-12-07 BR BRPI0519598-5A patent/BRPI0519598A2/pt not_active IP Right Cessation
- 2005-12-07 EP EP05818222A patent/EP1838309B1/en not_active Expired - Lifetime
- 2005-12-07 AT AT05818222T patent/ATE405262T1/de not_active IP Right Cessation
- 2005-12-07 MX MX2007007010A patent/MX2007007010A/es unknown
- 2005-12-07 CA CA002591412A patent/CA2591412A1/en not_active Abandoned
- 2005-12-07 AP AP2007004023A patent/AP2007004023A0/xx unknown
-
2007
- 2007-05-31 IL IL183602A patent/IL183602A0/en unknown
- 2007-05-31 NO NO20072764A patent/NO20072764L/no not_active Application Discontinuation
- 2007-06-15 TN TNP2007000227A patent/TNSN07227A1/fr unknown
- 2007-06-15 MA MA29996A patent/MA29095B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070086294A (ko) | 2007-08-27 |
| NO20072764L (no) | 2007-07-03 |
| IL183602A0 (en) | 2007-09-20 |
| MA29095B1 (fr) | 2007-12-03 |
| CA2591412A1 (en) | 2006-06-22 |
| EA200701087A1 (ru) | 2008-02-28 |
| ES2313444T3 (es) | 2009-03-01 |
| EP1838309B1 (en) | 2008-08-20 |
| ATE405262T1 (de) | 2008-09-15 |
| JP2008524199A (ja) | 2008-07-10 |
| EP1838309A1 (en) | 2007-10-03 |
| BRPI0519598A2 (pt) | 2009-03-10 |
| TNSN07227A1 (fr) | 2008-11-21 |
| EA011512B1 (ru) | 2009-04-28 |
| US20090291977A1 (en) | 2009-11-26 |
| DE602005009257D1 (de) | 2008-10-02 |
| MX2007007010A (es) | 2007-07-10 |
| AP2007004023A0 (en) | 2007-06-30 |
| WO2006064339A1 (en) | 2006-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |