AU2005305086A1 - Compositions for treating flushing and lipid-associated disorders comprising niacin receptor partial agonists - Google Patents
Compositions for treating flushing and lipid-associated disorders comprising niacin receptor partial agonists Download PDFInfo
- Publication number
- AU2005305086A1 AU2005305086A1 AU2005305086A AU2005305086A AU2005305086A1 AU 2005305086 A1 AU2005305086 A1 AU 2005305086A1 AU 2005305086 A AU2005305086 A AU 2005305086A AU 2005305086 A AU2005305086 A AU 2005305086A AU 2005305086 A1 AU2005305086 A1 AU 2005305086A1
- Authority
- AU
- Australia
- Prior art keywords
- niacin
- analog
- tetrazol
- pyrazole
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62553604P | 2004-11-05 | 2004-11-05 | |
| US60/625,536 | 2004-11-05 | ||
| PCT/US2005/039560 WO2006052569A1 (en) | 2004-11-05 | 2005-11-01 | Compositions for treating flushing and lipid-associated disorders comprising niacin receptor partial agonists |
Publications (1)
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| AU2005305086A1 true AU2005305086A1 (en) | 2006-05-18 |
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|---|---|---|---|
| AU2005305086A Abandoned AU2005305086A1 (en) | 2004-11-05 | 2005-11-01 | Compositions for treating flushing and lipid-associated disorders comprising niacin receptor partial agonists |
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| Country | Link |
|---|---|
| US (1) | US20080139628A1 (enExample) |
| EP (1) | EP1811996A1 (enExample) |
| JP (1) | JP2008519080A (enExample) |
| CN (1) | CN101076331A (enExample) |
| AU (1) | AU2005305086A1 (enExample) |
| CA (1) | CA2584225A1 (enExample) |
| WO (1) | WO2006052569A1 (enExample) |
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| TWI258478B (en) | 2003-10-31 | 2006-07-21 | Arena Pharm Inc | Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof |
| AU2004293415A1 (en) * | 2003-11-21 | 2005-06-09 | Arena Pharmaceuticals, Inc. | 4-oxo-4,5-dihydro-furan-2-carboxylic and acid derivatives and methods of treatment of metabolic-related disorders thereof |
| PL364348A1 (en) | 2004-01-12 | 2005-07-25 | PHARMENA Sp.z o.o. | Application of quaternary pyridine salts as vessel protection agent |
| DK1919466T3 (da) | 2005-07-11 | 2012-07-02 | Cortria Corp | Formuleringer til behandling af lipoprotein-abnormiteter omfattende et statin og et methylnicotinamidderivat |
| US20100204278A1 (en) * | 2006-10-20 | 2010-08-12 | Beresis Richard T | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment |
| NZ590790A (en) | 2008-07-08 | 2012-09-28 | Daiichi Sankyo Co Ltd | Nitrogen-containing aromatic heterocyclyl compound |
| JP5925770B2 (ja) * | 2010-06-24 | 2016-05-25 | トラスティーズ オブ タフツ カレッジ | ナイアシン模倣体、およびその使用方法 |
| EP2585072A4 (en) | 2010-06-24 | 2013-12-25 | Tufts College | MIMETICS OF NIACIN AND METHODS OF USE |
| CN103755637A (zh) * | 2013-12-26 | 2014-04-30 | 平湖优康药物研发有限公司 | 一种医药中间体1,4,5,6-四氢-3-环戊并吡唑甲腈的合成工艺 |
| US9456982B2 (en) | 2014-05-18 | 2016-10-04 | Be-Warm Llc | Solid formulations of niacin to counteract cold extremities |
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| US5126145A (en) * | 1989-04-13 | 1992-06-30 | Upsher Smith Laboratories Inc | Controlled release tablet containing water soluble medicament |
| US5268181A (en) * | 1989-04-13 | 1993-12-07 | Upsher-Smith Laboratories, Inc. | Method of using niacin to control nocturnal cholesterol synthesis |
| EP0821587A4 (en) * | 1995-04-19 | 1999-05-19 | Lipoprotein Technologies Inc | COMPOSITIONS, KITS AND METHODS FOR ADMINISTERING ANTILIPEMICS AND MEDICINES AGAINST PLATELET AGGREGATION |
| US6902902B2 (en) * | 2001-11-27 | 2005-06-07 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders |
| AU2003300014A1 (en) * | 2002-10-10 | 2004-05-04 | Arena Pharmaceuticals, Inc. | 5-substituted 2h-pyrazone-3-carboxylic acid derivatives as antilipolytic agents for the treatment of metabolic-related disorders such as dyslipidemia |
| TWI258478B (en) * | 2003-10-31 | 2006-07-21 | Arena Pharm Inc | Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof |
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2005
- 2005-11-01 CA CA002584225A patent/CA2584225A1/en not_active Abandoned
- 2005-11-01 EP EP05816215A patent/EP1811996A1/en not_active Withdrawn
- 2005-11-01 JP JP2007540384A patent/JP2008519080A/ja active Pending
- 2005-11-01 CN CNA2005800375213A patent/CN101076331A/zh active Pending
- 2005-11-01 WO PCT/US2005/039560 patent/WO2006052569A1/en not_active Ceased
- 2005-11-01 AU AU2005305086A patent/AU2005305086A1/en not_active Abandoned
- 2005-11-01 US US11/718,539 patent/US20080139628A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006052569A1 (en) | 2006-05-18 |
| CN101076331A (zh) | 2007-11-21 |
| JP2008519080A (ja) | 2008-06-05 |
| CA2584225A1 (en) | 2006-05-18 |
| EP1811996A1 (en) | 2007-08-01 |
| US20080139628A1 (en) | 2008-06-12 |
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| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |