AU2005298494B2 - System and method for carrying out fibered multiphoton microscopic imagery of a sample - Google Patents

System and method for carrying out fibered multiphoton microscopic imagery of a sample Download PDF

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Publication number
AU2005298494B2
AU2005298494B2 AU2005298494A AU2005298494A AU2005298494B2 AU 2005298494 B2 AU2005298494 B2 AU 2005298494B2 AU 2005298494 A AU2005298494 A AU 2005298494A AU 2005298494 A AU2005298494 A AU 2005298494A AU 2005298494 B2 AU2005298494 B2 AU 2005298494B2
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AU
Australia
Prior art keywords
image guide
sample
fibre
optical
excitation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU2005298494A
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English (en)
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AU2005298494A1 (en
Inventor
Alain Barthelemy
Francois Lacombe
Mickael Lelek
Alexandre Loiseau
Frederic Louradour
Dominique Pagnoux
Bertrand Viellerobe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite de Limoges
Mauna Kea Technologies SA
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite de Limoges
Mauna Kea Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite de Limoges, Mauna Kea Technologies SA filed Critical Centre National de la Recherche Scientifique CNRS
Publication of AU2005298494A1 publication Critical patent/AU2005298494A1/en
Application granted granted Critical
Publication of AU2005298494B2 publication Critical patent/AU2005298494B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2476—Non-optical details, e.g. housings, mountings, supports
    • G02B23/2484—Arrangements in relation to a camera or imaging device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2461—Illumination
    • G02B23/2469—Illumination using optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0068—Confocal scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/10—Scanning
    • G01N2201/105—Purely optical scan
    • G01N2201/1053—System of scan mirrors for composite motion of beam
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/04—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings formed by bundles of fibres

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Astronomy & Astrophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Multimedia (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Endoscopes (AREA)
AU2005298494A 2004-10-22 2005-10-21 System and method for carrying out fibered multiphoton microscopic imagery of a sample Expired AU2005298494B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0411313A FR2877103B1 (fr) 2004-10-22 2004-10-22 Systeme et procede d'imagerie microscopique multiphotonique fibre d'un echantillon
FR0411313 2004-10-22
PCT/FR2005/002630 WO2006045936A2 (fr) 2004-10-22 2005-10-21 Systeme et procede d’imagerie microscopique multiphotonique fibre d’un echantillon

Publications (2)

Publication Number Publication Date
AU2005298494A1 AU2005298494A1 (en) 2006-05-04
AU2005298494B2 true AU2005298494B2 (en) 2011-08-11

Family

ID=34951919

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005298494A Expired AU2005298494B2 (en) 2004-10-22 2005-10-21 System and method for carrying out fibered multiphoton microscopic imagery of a sample

Country Status (8)

Country Link
US (1) US8237131B2 (enExample)
EP (1) EP1817620B8 (enExample)
JP (1) JP5102622B2 (enExample)
AU (1) AU2005298494B2 (enExample)
CA (1) CA2584748C (enExample)
ES (1) ES2396426T3 (enExample)
FR (1) FR2877103B1 (enExample)
WO (1) WO2006045936A2 (enExample)

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DE102009029831A1 (de) 2009-06-17 2011-01-13 W.O.M. World Of Medicine Ag Vorrichtung und Verfahren für die Mehr-Photonen-Fluoreszenzmikroskopie zur Gewinnung von Informationen aus biologischem Gewebe
US8507877B2 (en) * 2009-11-25 2013-08-13 Ofs Fitel, Llc Non-linear optical system and techniques
US9304308B2 (en) * 2009-12-09 2016-04-05 Advanced Micro Devices, Inc. Laser scanning module including an optical isolator
US20110147615A1 (en) * 2009-12-23 2011-06-23 Kintz Gregory J Method and apparatus for microscopic imaging system with wide field of view and high collection efficiency
RS61066B1 (sr) * 2010-03-05 2020-12-31 Massachusetts Gen Hospital Sistemi koji obezbeđuju mikroskopske slike najmanje jedne anatomske strukture na određenoj rezoluciji
WO2012167201A1 (en) * 2011-06-01 2012-12-06 Digital Light Innovations System and method for hyperspectral illumination
WO2012170963A1 (en) 2011-06-08 2012-12-13 Digital Light Innovations System and method for hyperspectral imaging
US9356413B2 (en) * 2011-09-30 2016-05-31 Olympus Corporation Laser source apparatus and laser microscope
EP2785250A4 (en) * 2011-11-28 2015-07-29 Univ Leland Stanford Junior SYSTEM AND METHOD FOR SARCOME REPRESENTATION THROUGH LENS-BASED MICROSCOPY
WO2015108991A2 (en) 2014-01-17 2015-07-23 Imra America, Inc. Laser-based modification of transparent materials
JP2017513211A (ja) * 2014-02-28 2017-05-25 イムラ アメリカ インコーポレイテッド 顕微鏡に適用される多波長超短パルスの生成及び放出
DE112015001154T5 (de) * 2014-04-24 2016-12-08 Olympus Corporation Mikroskop und Mikroskopie-Verfahren
JP2015227778A (ja) * 2014-05-30 2015-12-17 ソニー株式会社 画像取得装置及び画像取得方法
FR3030956B1 (fr) * 2014-12-18 2018-03-23 Centre National De La Recherche Scientifique - Cnrs Dispositif de transport et de controle d'impulsions lumineuses pour l'imagerie endo-microscopique sans lentille
JP6594437B2 (ja) 2015-09-15 2019-10-23 オリンパス株式会社 顕微鏡および顕微鏡観察方法
JP7245051B2 (ja) 2016-03-08 2023-03-23 エンスペクトラ・ヘルス・インコーポレイテッド 皮膚の疾患の非侵襲的な検出
CN109310296A (zh) 2016-04-06 2019-02-05 爱丁堡大学董事会 内窥镜成像装置及方法
US9645291B1 (en) * 2016-04-18 2017-05-09 Ii-Vi Incorporated Voltage-tunable optical filters for instrumentation applications
WO2018201082A1 (en) 2017-04-28 2018-11-01 Zebra Medical Technologies, Inc. Systems and methods for imaging and measurement of sarcomeres
GB201707239D0 (en) 2017-05-05 2017-06-21 Univ Edinburgh Optical system and method
WO2020010330A1 (en) * 2018-07-06 2020-01-09 The Trustees Of Columbia University In The City Of New York Collagen tissue modification
WO2020102442A1 (en) 2018-11-13 2020-05-22 Enspectra Health, Inc. Methods and systems for generating depth profiles
CN109656014B (zh) * 2019-01-31 2024-03-19 北京超维景生物科技有限公司 多路荧光收集装置及三维非线性激光扫描腔体内窥镜
CN113349708B (zh) * 2021-06-08 2023-05-26 之江实验室 一种基于大色散镜头的双模态高分辨大深度显微内窥成像系统
KR102567260B1 (ko) * 2021-09-01 2023-08-16 연세대학교 산학협력단 망막 진단 시스템 및 이를 이용한 망막 진단방법
CN114755210A (zh) * 2022-04-22 2022-07-15 波粒光子(苏州)精密光电科技有限公司 高性能光纤荧光探测器及其生产方法
CN119523389B (zh) * 2024-11-20 2025-09-23 卓外（上海）医疗电子科技有限公司 一种基于谐波成像和多光子荧光成像的内窥镜系统

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US4655547A (en) * 1985-04-09 1987-04-07 Bell Communications Research, Inc. Shaping optical pulses by amplitude and phase masking
US5606445A (en) * 1993-09-03 1997-02-25 Hitachi, Ltd. Optical transmission system
US6249630B1 (en) * 1996-12-13 2001-06-19 Imra America, Inc. Apparatus and method for delivery of dispersion-compensated ultrashort optical pulses with high peak power
US6449039B1 (en) * 1999-07-28 2002-09-10 Thermo Noran Inc. Laser scanning fluorescence microscopy with compensation for spatial dispersion of fast laser pulses
JP2003344777A (ja) * 2002-05-24 2003-12-03 Japan Science & Technology Corp 光ファイバ顕微鏡および内視鏡
WO2004008952A1 (fr) * 2002-07-18 2004-01-29 Mauna Kea Technologies Procede et appareillage d'imagerie de fluorescence haute resolution par fibre optique et notamment d’imagerie confocale

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US4655547A (en) * 1985-04-09 1987-04-07 Bell Communications Research, Inc. Shaping optical pulses by amplitude and phase masking
US5606445A (en) * 1993-09-03 1997-02-25 Hitachi, Ltd. Optical transmission system
US6249630B1 (en) * 1996-12-13 2001-06-19 Imra America, Inc. Apparatus and method for delivery of dispersion-compensated ultrashort optical pulses with high peak power
US6449039B1 (en) * 1999-07-28 2002-09-10 Thermo Noran Inc. Laser scanning fluorescence microscopy with compensation for spatial dispersion of fast laser pulses
JP2003344777A (ja) * 2002-05-24 2003-12-03 Japan Science & Technology Corp 光ファイバ顕微鏡および内視鏡
WO2004008952A1 (fr) * 2002-07-18 2004-01-29 Mauna Kea Technologies Procede et appareillage d'imagerie de fluorescence haute resolution par fibre optique et notamment d’imagerie confocale

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Also Published As

Publication number Publication date
EP1817620B8 (fr) 2012-12-12
US8237131B2 (en) 2012-08-07
AU2005298494A1 (en) 2006-05-04
WO2006045936A2 (fr) 2006-05-04
JP5102622B2 (ja) 2012-12-19
WO2006045936A3 (fr) 2006-06-22
FR2877103B1 (fr) 2012-02-10
EP1817620B1 (fr) 2012-09-26
FR2877103A1 (fr) 2006-04-28
EP1817620A2 (fr) 2007-08-15
CA2584748A1 (fr) 2006-05-04
CA2584748C (fr) 2015-10-13
US20070290145A1 (en) 2007-12-20
JP2008517291A (ja) 2008-05-22
ES2396426T3 (es) 2013-02-21

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