AU2005239984B2 - Use of equol for treating skin diseases - Google Patents
Use of equol for treating skin diseases Download PDFInfo
- Publication number
- AU2005239984B2 AU2005239984B2 AU2005239984A AU2005239984A AU2005239984B2 AU 2005239984 B2 AU2005239984 B2 AU 2005239984B2 AU 2005239984 A AU2005239984 A AU 2005239984A AU 2005239984 A AU2005239984 A AU 2005239984A AU 2005239984 B2 AU2005239984 B2 AU 2005239984B2
- Authority
- AU
- Australia
- Prior art keywords
- equol
- skin
- dht
- hair
- androgen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- ADFCQWZHKCXPAJ-GFCCVEGCSA-N equol Chemical compound C1=CC(O)=CC=C1[C@@H]1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-GFCCVEGCSA-N 0.000 title claims description 437
- ADFCQWZHKCXPAJ-UHFFFAOYSA-N indofine Natural products C1=CC(O)=CC=C1C1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-UHFFFAOYSA-N 0.000 title claims description 351
- 235000019126 equol Nutrition 0.000 title claims description 347
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- ADFCQWZHKCXPAJ-LBPRGKRZSA-N (R)-Equol Chemical compound C1=CC(O)=CC=C1[C@H]1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-LBPRGKRZSA-N 0.000 claims description 75
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| US52145704P | 2004-04-28 | 2004-04-28 | |
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| WO2004039327A2 (en) * | 2002-10-29 | 2004-05-13 | Colorado State University Research Foundation | Use of equol for treating androgen mediated diseases |
| US8668914B2 (en) * | 2002-07-24 | 2014-03-11 | Brigham Young University | Use of equol for treating skin diseases |
| US8580846B2 (en) | 2002-10-29 | 2013-11-12 | Brigham Young University | Use of equol for ameliorating or preventing neuropsychiatric and neurodegenerative diseases or disorders |
| US20080108696A1 (en) | 2006-08-02 | 2008-05-08 | Brinton Roberta D | Phytoestrogenic Formulations for Alleviation or Prevention of Neurodegenerative Diseases |
| US8680140B2 (en) * | 2006-08-02 | 2014-03-25 | University Of Southern California | Phytoestrogenic formulations for alleviation or prevention of menopausal symptoms |
| EP2063898A4 (en) | 2006-08-18 | 2012-02-15 | Univ Brigham Young | USE OF EQUOL TO IMPROVE OR PREVENT NEUROPSYCHIATRIC AND NEURODEGENERATIVE DISEASES OR DISORDERS |
| WO2008100560A2 (en) * | 2007-02-14 | 2008-08-21 | University Of Southern California | Estrogen receptor modulators, associated pharmaceutical compositions and methods of use |
| US8147759B2 (en) | 2007-08-29 | 2012-04-03 | Cem Corporation | Automated protein analyzer |
| US8852948B2 (en) * | 2007-08-29 | 2014-10-07 | Cem Corporation | Colorimetric protein analysis method |
| WO2009061832A1 (en) * | 2007-11-05 | 2009-05-14 | Kci Licensing Inc. | Identification of tissue for debridement |
| US20090222281A1 (en) * | 2008-03-03 | 2009-09-03 | Vibhuti Uppal | Formulation for multi-step acne treatment |
| US20110091435A1 (en) * | 2008-10-24 | 2011-04-21 | University Of Southern California | Phytoestrogenic formulations for alleviation or prevention of hair loss |
| US20100247693A1 (en) * | 2009-03-24 | 2010-09-30 | Marini Jan L | Cosmetic formulation to treat rosacea telangiectasia |
| WO2011022652A1 (en) | 2009-08-21 | 2011-02-24 | Novan, Inc. | Topical gels |
| BR112012003804B1 (pt) | 2009-08-21 | 2019-02-19 | Novan, Inc. | Curativo para ferimentos, método para formar um curativo para ferimentos, e, kit de curativo para ferimento |
| MX339842B (es) | 2009-12-22 | 2016-06-14 | Avon Prod Inc | Composiciones estimuladoras de paxilina y usos cosmeticos de las mismas. |
| CA2800838C (en) * | 2010-05-28 | 2020-03-10 | M. Alphabet 1, L.L.C. | Combination therapy for skin disorders |
| US8591876B2 (en) * | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| CN102764253B (zh) * | 2012-07-16 | 2014-03-05 | 上海交通大学 | 苯并吡喃生物碱的应用 |
| JP2017531025A (ja) * | 2014-10-14 | 2017-10-19 | ジャクソン，リチャード・エル | Ｓ−エクオールの無水結晶形 |
| JP7068816B2 (ja) * | 2017-12-15 | 2022-05-17 | 大塚製薬株式会社 | エクオールおよびコラーゲンペプチドを含有する経口組成物 |
| AU2019285640A1 (en) | 2018-06-15 | 2021-01-21 | Board Of Regents Of The University Of Texas System | Methods of treating and preventing breast cancer with S-equol |
| JP2021535187A (ja) * | 2018-06-15 | 2021-12-16 | ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | Ｓ−エクオールを用いた黒色腫の処置及び予防方法 |
| JP7596493B1 (ja) * | 2023-11-24 | 2024-12-09 | 株式会社ダイセル | 男性のｑｏｌの改善のための組成物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004009035A2 (en) * | 2002-07-24 | 2004-01-29 | Children's Hospital Medical Center | Compositions and products containing enantiomeric equol, and methods for their making |
| AU2003286781A1 (en) * | 2002-10-29 | 2004-05-25 | Brigham Young University | Use of equol for treating androgen mediated diseases |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4390559A (en) * | 1979-04-11 | 1983-06-28 | Z-L Limited Partnership | Isoflavones and related compounds, methods of preparing and using and antioxidant compositions containing same |
| US5468501A (en) | 1982-09-01 | 1995-11-21 | Hercon Laboratories Corporation | Article useful for administration of pharmacologically-active substances transdermally, orally or by means of implant |
| USRE34457E (en) * | 1983-12-28 | 1993-11-30 | Daicel Chemical Industries, Inc. | Separating agent |
| GB8626344D0 (en) * | 1986-11-04 | 1986-12-03 | Zyma Sa | Bicyclic compounds |
| CH679584A5 (https=) * | 1989-11-10 | 1992-03-13 | Nestle Sa | |
| TW279133B (https=) | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
| EP0656786B2 (en) * | 1992-05-19 | 2014-04-23 | Novogen Research Pty Ltd | Use of isoflavone phyto-oestrogen extracts of soy or clover |
| US5436007A (en) | 1992-10-23 | 1995-07-25 | Abbott Laboratories | Diaper rash lotion |
| WO1994023716A1 (en) * | 1993-04-16 | 1994-10-27 | Tufts University School Of Medicine | Method for treatment of menopausal and premenstrual symptoms |
| US5613958A (en) | 1993-05-12 | 1997-03-25 | Pp Holdings Inc. | Transdermal delivery systems for the modulated administration of drugs |
| US5320949A (en) * | 1993-10-12 | 1994-06-14 | Protein Technologies International, Inc. | Process for producing aglucone isoflavone enriched vegetable protein fiber |
| US5424331A (en) * | 1994-06-10 | 1995-06-13 | Bio-Virus Research Incorporated | Pharmaceutical compositions and dietary soybean food products for the prevention of osteoporosis |
| US5523087A (en) * | 1995-02-15 | 1996-06-04 | Bio-Virus Research Incorporated | Pharmaceutical compositions for the treatment of diabetic male sexual dysfunction |
| AUPN166195A0 (en) * | 1995-03-13 | 1995-04-06 | Norvet Research Pty Limited | Process for glucan extraction |
| FR2731706B1 (fr) * | 1995-03-14 | 1997-04-11 | Cird Galderma | Composes heterocycliques aromatiques, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
| CN1188189C (zh) | 1995-06-07 | 2005-02-09 | 奥瑟－麦内尔制药公司 | 基质层含有17－脱乙酰基诺孕酯的经皮贴片及基质的用途 |
| US5693018A (en) | 1995-10-11 | 1997-12-02 | Science Incorporated | Subdermal delivery device |
| US5821361A (en) * | 1996-06-11 | 1998-10-13 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
| AUPO203996A0 (en) * | 1996-08-30 | 1996-09-26 | Novogen Research Pty Ltd | Therapeutic uses |
| US5726034A (en) * | 1996-09-06 | 1998-03-10 | Protein Technologies International, Inc. | Aglucone isoflavone enriched vegetable protein extract and protein material, and high genistein and daidzein content materials and process for producing the same |
| US6020471A (en) * | 1996-09-13 | 2000-02-01 | Abbott Laboratories | Process for isolating phytoestrogens from plant protein |
| US5804234A (en) * | 1996-09-13 | 1998-09-08 | Suh; John D. | Plant protein for nutritional products and method of making same |
| US5733926A (en) * | 1996-12-13 | 1998-03-31 | Gorbach; Sherwood L. | Isoflavonoids for treatment and prevention of alzheimer dementia and reduced cognitive functions |
| AUPO427196A0 (en) * | 1996-12-19 | 1997-01-23 | University Of Sydney, The | A method for preventing or controlling cataract |
| US6146668A (en) * | 1997-04-28 | 2000-11-14 | Novogen, Inc. | Preparation of isoflavones from legumes |
| EP0979074A4 (en) * | 1997-05-01 | 2003-07-09 | Novogen Inc | TREATMENT OR PREVENTION CLIMATE ACTION SYMPTOMS AND OSTEOPOROSIS |
| US6083526A (en) * | 1997-05-22 | 2000-07-04 | Gorbach; Sherwood L. | Use of isoflavonoids in the treatment or prevention of postpartum depression |
| US6060070A (en) * | 1997-06-11 | 2000-05-09 | Gorbach; Sherwood L. | Isoflavonoids for treatment and prevention of aging skin and wrinkles |
| JP4310601B2 (ja) * | 1997-08-08 | 2009-08-12 | 大塚製薬株式会社 | イソフラボン含有組成物 |
| US6521433B1 (en) * | 1997-09-17 | 2003-02-18 | E. I. Du Pont De Nemours And Company | cDNA sequences from plants that encode activities associated with isoflavone biosynthesis |
| US5855892A (en) * | 1997-09-19 | 1999-01-05 | Potter; Susan M. | Method for decreasing LDL-cholesterol concentration and increasing HDL-cholesterol concentration in the blood to reduce the risk of atherosclerosis and vascular disease |
| US5952374A (en) * | 1997-09-29 | 1999-09-14 | Protein Technologies International, Inc. | Method for inhibiting the development of Alzheimer's disease and related dementias- and for preserving cognitive function |
| US5942539A (en) * | 1997-10-03 | 1999-08-24 | Wake Forest University | Methods of treating or preventing endometriosis with phytoestrogens |
| AUPP112497A0 (en) * | 1997-12-24 | 1998-01-22 | Novogen Research Pty Ltd | Compositions and method for protecting skin from UV induced immunosupression and skin damage |
| US5958946A (en) * | 1998-01-20 | 1999-09-28 | Styczynski; Peter | Modulation of hair growth |
| US6004558A (en) * | 1998-02-25 | 1999-12-21 | Novogen, Inc. | Methods for treating cancer with legume plant extracts |
| AUPP260798A0 (en) * | 1998-03-26 | 1998-04-23 | Novogen Research Pty Ltd | Treatment of medical related conditions with isoflavone containing extracts of clover |
| EP1041964A4 (en) * | 1998-09-10 | 2003-09-03 | Avon Prod Inc | METHOD AND COMPOSITIONS FOR REDUCING DERMATOLOGICAL AGING AND FOR REDUCING CRUSHING |
| WO2000030664A1 (en) * | 1998-11-25 | 2000-06-02 | Nutri Pharma Asa | Composition comprising soy protein, dietary fibres and a phytoestrogen compound and use thereof in the prevention and/or treatment of pulmonary diseases |
| JP2002542187A (ja) * | 1999-04-16 | 2002-12-10 | アストラゼネカ・アクチエボラーグ | エストロゲン−β受容体リガンド |
| US6544566B1 (en) * | 1999-04-23 | 2003-04-08 | Protein Technologies International, Inc. | Composition containing plant sterol, soy protein and isoflavone for reducing LDL cholesterol |
| US6159959A (en) * | 1999-05-06 | 2000-12-12 | American Home Products Corporation | Combined estrogen and antiestrogen therapy |
| US6375994B1 (en) * | 1999-08-20 | 2002-04-23 | Sun Ten Laboratories, Inc. | Preparation of fiber, L-glutamine and a soy derivative for the purpose of enhancement of isoflavone bioavailability |
| DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| CA2416796A1 (en) * | 2000-06-14 | 2001-12-20 | Alla Shapiro | Radioprotective agents |
| US6455568B2 (en) * | 2000-07-06 | 2002-09-24 | Wyeth | Combination therapy for inhibiting sphincter incontinence |
| US6326366B1 (en) * | 2000-08-22 | 2001-12-04 | Protein Technologies International | Hormone replacement therapy |
| US6565864B2 (en) * | 2000-12-28 | 2003-05-20 | Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. | Skin care product containing retinoids and phytoestrogens in a dual compartment package |
| EP1234572B1 (de) * | 2001-02-26 | 2013-10-30 | Mibelle AG Cosmetics | Isoflavon-Aglykone enhaltende Hautbehandlungsmittel |
| MXPA03007609A (es) * | 2001-02-27 | 2004-06-30 | Univ Michigan | Uso de inhibidores egfr naturales para evitar efectos secundarios debidos a terapia de retinoide, jabones y otros estimulos que activan el receptor del factor de crecimiento epidermico. |
| DE10121375B4 (de) * | 2001-05-02 | 2014-01-16 | Beiersdorf Ag | Verwendung von Isoflavonoiden in kosmetischen oder dermatologischen Zubereitungen zur Prophylaxe vor und Behandlung von sensibler Haut |
| FR2825277B1 (fr) * | 2001-05-30 | 2004-10-15 | Oreal | Composition cosmetique et/ou dermatologique et/ou pharmaceutique contenant au moins un compose ihnibiteur de l'enzime 3, b-hsd |
| US6597597B2 (en) * | 2001-11-13 | 2003-07-22 | Hewlett-Packard Company | Low temperature attaching process for MRAM components |
| EP1542654A4 (en) * | 2002-09-23 | 2008-12-17 | Novogen Res Pty Ltd | TREATMENT OF PHOTOTATIOOD AND ACTINIC DETERIORATION OF THE SKIN |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004009035A2 (en) * | 2002-07-24 | 2004-01-29 | Children's Hospital Medical Center | Compositions and products containing enantiomeric equol, and methods for their making |
| AU2003286781A1 (en) * | 2002-10-29 | 2004-05-25 | Brigham Young University | Use of equol for treating androgen mediated diseases |
Also Published As
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|---|---|
| JP2013006874A (ja) | 2013-01-10 |
| CA2564399A1 (en) | 2005-11-17 |
| EP1740191A4 (en) | 2008-07-30 |
| EP1740191A1 (en) | 2007-01-10 |
| JP5220406B2 (ja) | 2013-06-26 |
| AU2005239984A1 (en) | 2005-11-17 |
| WO2005107770A1 (en) | 2005-11-17 |
| JP2007534751A (ja) | 2007-11-29 |
| EP2305272A1 (en) | 2011-04-06 |
| US20050245492A1 (en) | 2005-11-03 |
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