AU2004299105B8 - Active immunization against clostridium difficile disease - Google Patents

Active immunization against clostridium difficile disease Download PDF

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Publication number
AU2004299105B8
AU2004299105B8 AU2004299105A AU2004299105A AU2004299105B8 AU 2004299105 B8 AU2004299105 B8 AU 2004299105B8 AU 2004299105 A AU2004299105 A AU 2004299105A AU 2004299105 A AU2004299105 A AU 2004299105A AU 2004299105 B8 AU2004299105 B8 AU 2004299105B8
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AU
Australia
Prior art keywords
toxin
difficile
toxoid
antibiotic
vaccine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004299105A
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English (en)
Other versions
AU2004299105A1 (en
AU2004299105A2 (en
AU2004299105B2 (en
Inventor
Paul J. Giannasca
Wende Lei
Thomas P. Monath
William D. Thomas Jr.
Zhenxi Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Biologics LLC
Original Assignee
Sanofi Pasteur Biologics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34700454&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2004299105(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Pasteur Biologics LLC filed Critical Sanofi Pasteur Biologics LLC
Publication of AU2004299105A1 publication Critical patent/AU2004299105A1/en
Publication of AU2004299105A2 publication Critical patent/AU2004299105A2/en
Application granted granted Critical
Publication of AU2004299105B2 publication Critical patent/AU2004299105B2/en
Priority to AU2011201804A priority Critical patent/AU2011201804B2/en
Publication of AU2004299105B8 publication Critical patent/AU2004299105B8/en
Assigned to SANOFI PASTEUR BIOLOGICS, LLC reassignment SANOFI PASTEUR BIOLOGICS, LLC Request to Amend Deed and Register Assignors: ACAMBIS INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
AU2004299105A 2003-12-16 2004-12-15 Active immunization against clostridium difficile disease Ceased AU2004299105B8 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2011201804A AU2011201804B2 (en) 2003-12-16 2011-04-20 Active immunization against clostridium difficile disease

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/737,270 2003-12-16
US10/737,270 US6969520B2 (en) 1997-10-20 2003-12-16 Active immunization against clostridium difficile disease
PCT/US2004/042277 WO2005058353A1 (en) 2003-12-16 2004-12-15 Passive immunization against clostridium difficile disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2011201804A Division AU2011201804B2 (en) 2003-12-16 2011-04-20 Active immunization against clostridium difficile disease

Publications (4)

Publication Number Publication Date
AU2004299105A1 AU2004299105A1 (en) 2005-06-30
AU2004299105A2 AU2004299105A2 (en) 2005-06-30
AU2004299105B2 AU2004299105B2 (en) 2011-01-20
AU2004299105B8 true AU2004299105B8 (en) 2011-05-12

Family

ID=34700454

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2004299105A Ceased AU2004299105B8 (en) 2003-12-16 2004-12-15 Active immunization against clostridium difficile disease
AU2011201804A Ceased AU2011201804B2 (en) 2003-12-16 2011-04-20 Active immunization against clostridium difficile disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2011201804A Ceased AU2011201804B2 (en) 2003-12-16 2011-04-20 Active immunization against clostridium difficile disease

Country Status (7)

Country Link
US (6) US6969520B2 (enExample)
EP (2) EP1708743B1 (enExample)
JP (3) JP4904163B2 (enExample)
AU (2) AU2004299105B8 (enExample)
CA (1) CA2550108C (enExample)
DK (1) DK1708743T3 (enExample)
WO (1) WO2005058353A1 (enExample)

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Also Published As

Publication number Publication date
AU2004299105A1 (en) 2005-06-30
US6969520B2 (en) 2005-11-29
US20150030612A1 (en) 2015-01-29
AU2004299105A2 (en) 2005-06-30
CA2550108C (en) 2018-05-15
JP4904163B2 (ja) 2012-03-28
US20130177592A1 (en) 2013-07-11
CA2550108A1 (en) 2005-06-30
US20160287689A1 (en) 2016-10-06
EP1708743B1 (en) 2015-06-17
DK1708743T3 (en) 2015-07-13
JP2015205919A (ja) 2015-11-19
AU2011201804B2 (en) 2013-08-01
EP1708743A4 (en) 2009-03-04
US20070231336A1 (en) 2007-10-04
US20040126383A1 (en) 2004-07-01
AU2004299105B2 (en) 2011-01-20
US20060029608A1 (en) 2006-02-09
US9226956B2 (en) 2016-01-05
JP6130622B2 (ja) 2017-05-17
JP2012031182A (ja) 2012-02-16
JP2007514749A (ja) 2007-06-07
EP2394658A3 (en) 2011-12-21
HK1099198A1 (en) 2007-08-10
EP2394658A2 (en) 2011-12-14
WO2005058353A1 (en) 2005-06-30
AU2011201804A1 (en) 2011-05-12
EP1708743A1 (en) 2006-10-11

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