AU2004281817B2 - A method for increasing CD8+ cytotoxic T cell reponses and for treating multiple sclerosis - Google Patents

A method for increasing CD8+ cytotoxic T cell reponses and for treating multiple sclerosis Download PDF

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Publication number
AU2004281817B2
AU2004281817B2 AU2004281817A AU2004281817A AU2004281817B2 AU 2004281817 B2 AU2004281817 B2 AU 2004281817B2 AU 2004281817 A AU2004281817 A AU 2004281817A AU 2004281817 A AU2004281817 A AU 2004281817A AU 2004281817 B2 AU2004281817 B2 AU 2004281817B2
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Australia
Prior art keywords
cells
mbp
fragment
autologous
seq
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Ceased
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AU2004281817A
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English (en)
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AU2004281817A1 (en
Inventor
Ying C. Q. Zang
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Baylor College of Medicine
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Baylor College of Medicine
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Publication of AU2004281817A1 publication Critical patent/AU2004281817A1/en
Application granted granted Critical
Publication of AU2004281817B2 publication Critical patent/AU2004281817B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0008Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22Immunosuppressive or immunotolerising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/416Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/45Bacterial antigens
    • A61K40/453Clostridium, e.g. Clostridium tetani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2004281817A 2003-10-17 2004-10-18 A method for increasing CD8+ cytotoxic T cell reponses and for treating multiple sclerosis Ceased AU2004281817B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51221203P 2003-10-17 2003-10-17
US60/512,212 2003-10-17
PCT/US2004/034448 WO2005037309A1 (en) 2003-10-17 2004-10-18 A method for increasing cd8+ cytotoxic t cell reponses and for treating multiple sclerosis

Publications (2)

Publication Number Publication Date
AU2004281817A1 AU2004281817A1 (en) 2005-04-28
AU2004281817B2 true AU2004281817B2 (en) 2010-07-22

Family

ID=34465326

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004281817A Ceased AU2004281817B2 (en) 2003-10-17 2004-10-18 A method for increasing CD8+ cytotoxic T cell reponses and for treating multiple sclerosis

Country Status (10)

Country Link
US (2) US20080107664A1 (cg-RX-API-DMAC7.html)
EP (1) EP1677821B1 (cg-RX-API-DMAC7.html)
JP (1) JP2007509063A (cg-RX-API-DMAC7.html)
CN (1) CN1893971A (cg-RX-API-DMAC7.html)
AU (1) AU2004281817B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0415519A (cg-RX-API-DMAC7.html)
CA (1) CA2542668C (cg-RX-API-DMAC7.html)
IL (1) IL174935A (cg-RX-API-DMAC7.html)
NZ (1) NZ546552A (cg-RX-API-DMAC7.html)
WO (1) WO2005037309A1 (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007509063A (ja) * 2003-10-17 2007-04-12 ベイラー カレッジ オブ メディスン Cd8+細胞傷害性t細胞応答を増大させる方法、および多発性硬化症を処置するための方法
ES2553192T3 (es) * 2006-05-05 2015-12-04 Opexa Therapeutics Vacuna de células T
EP2050814A1 (en) * 2007-10-17 2009-04-22 Txcell Compositions for treating multiple sclerosis
US9125850B2 (en) * 2009-11-14 2015-09-08 Cardio Vax, Llc Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis
RU2435556C1 (ru) * 2010-04-23 2011-12-10 Владимир Васильевич Лантух Способ лечения дистрофических заболеваний заднего полюса глаза
WO2013063713A1 (zh) * 2011-10-31 2013-05-10 鑫品生医科技股份有限公司 诱发产生综合免疫细胞的方法
CN105085615A (zh) * 2014-05-23 2015-11-25 上海市普陀区中心医院 一种多肽序列及其应用
CN105085616A (zh) * 2014-05-23 2015-11-25 上海市普陀区中心医院 一种氨基酸序列及其应用
KR20190124214A (ko) * 2017-01-20 2019-11-04 아타라 바이오테라퓨틱스 인크. 자가 t 세포를 사용하여 다발성 경화증을 치료하는 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003024393A2 (en) * 2001-09-14 2003-03-27 Opexa Pharmaceuticals, Inc. Autologous t-cell vaccines materials and method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU680824B2 (en) 1992-04-09 1997-08-14 Autoimmune, Inc. Suppression of T-cell proliferation using peptide fragments of myelin basic protein
US6410518B1 (en) * 1994-05-31 2002-06-25 Isis Pharmaceuticals, Inc. Antisense oligonucleotide inhibition of raf gene expression
CA2330458A1 (en) 1998-04-29 1999-11-04 Georgetown University Methods of identifying and using hla binding compounds as hla-agonists and antagonists
PT1407004E (pt) * 2001-05-15 2009-08-31 Ortho Mcneil Janssen Pharm Iniciação ex-vivo para produção de linfócitos t citotóxicos específicos de ligando-cd40 para tratar doenças autoimunes e alérgicas
IL164376A0 (en) 2002-04-03 2005-12-18 Applied Research Systems Ox4or binding agents, their preparation and pharmaceutical compositions containing them
JP2007509063A (ja) * 2003-10-17 2007-04-12 ベイラー カレッジ オブ メディスン Cd8+細胞傷害性t細胞応答を増大させる方法、および多発性硬化症を処置するための方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003024393A2 (en) * 2001-09-14 2003-03-27 Opexa Pharmaceuticals, Inc. Autologous t-cell vaccines materials and method

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Huseby et al (2001) Journal of Experimental Medicine, 194(5):669-676 *
Jurewicz et al (1998) Journal of Immunology, 160:3056-3059 *
Martin et al (1991) Journal of Experimental Medicine, 173(1):19-24 *
Steinman (2001) Journal of Experimental Medicine, 194(5):F27-F30 *
Sun et al (2001) Journal of Immunology, 166(12):7579-7587 *
Tsuchida et al (1004) Proceedings of the National Academy of Sciences of USA, 91(23):10859-10863 *

Also Published As

Publication number Publication date
AU2004281817A1 (en) 2005-04-28
BRPI0415519A (pt) 2006-12-26
US20100183546A1 (en) 2010-07-22
EP1677821B1 (en) 2013-02-27
IL174935A (en) 2012-01-31
NZ546552A (en) 2009-10-30
CN1893971A (zh) 2007-01-10
CA2542668A1 (en) 2005-04-28
US20080107664A1 (en) 2008-05-08
EP1677821A1 (en) 2006-07-12
CA2542668C (en) 2014-04-29
JP2007509063A (ja) 2007-04-12
IL174935A0 (en) 2006-08-20
WO2005037309A1 (en) 2005-04-28

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NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO ENTER THE NATIONAL PHASE HAS BEEN EXTENDED TO 17 JUN 2006.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired