AU2004238558A1 - N-sulphonylated amino acid derivatives, method for the production and use thereof - Google Patents
N-sulphonylated amino acid derivatives, method for the production and use thereof Download PDFInfo
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- AU2004238558A1 AU2004238558A1 AU2004238558A AU2004238558A AU2004238558A1 AU 2004238558 A1 AU2004238558 A1 AU 2004238558A1 AU 2004238558 A AU2004238558 A AU 2004238558A AU 2004238558 A AU2004238558 A AU 2004238558A AU 2004238558 A1 AU2004238558 A1 AU 2004238558A1
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- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 150000003862 amino acid derivatives Chemical class 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims description 162
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
- 125000003118 aryl group Chemical group 0.000 claims description 20
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 18
- 229910052736 halogen Inorganic materials 0.000 claims description 14
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10322191.3 | 2003-05-16 | ||
| DE10322191.3A DE10322191B4 (de) | 2003-05-16 | 2003-05-16 | N-sulfonylierte Aminosäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| PCT/EP2004/005291 WO2004101507A2 (de) | 2003-05-16 | 2004-05-17 | N-sulfonylierte aminosäurederivate und ihre verwendung als matriptase-inhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2004238558A1 true AU2004238558A1 (en) | 2004-11-25 |
Family
ID=33440914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2004238558A Abandoned AU2004238558A1 (en) | 2003-05-16 | 2004-05-17 | N-sulphonylated amino acid derivatives, method for the production and use thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7772251B2 (enExample) |
| EP (2) | EP1651597A2 (enExample) |
| JP (1) | JP4653100B2 (enExample) |
| AU (1) | AU2004238558A1 (enExample) |
| CA (1) | CA2525886C (enExample) |
| DE (1) | DE10322191B4 (enExample) |
| WO (1) | WO2004101507A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE399175T1 (de) * | 2002-03-11 | 2008-07-15 | Curacyte Ag | Hemmstoffe der urokinase, ihre herstellung und verwendung |
| DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
| DE10322191B4 (de) * | 2003-05-16 | 2014-02-27 | The Medicines Company (Leipzig) Gmbh | N-sulfonylierte Aminosäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DE10342108A1 (de) * | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
| JP2008510726A (ja) * | 2004-08-20 | 2008-04-10 | エントレメッド インコーポレイテッド | プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法 |
| DE102005044319A1 (de) * | 2005-09-16 | 2007-03-22 | Curacyte Chemistry Gmbh | 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa |
| JP5406722B2 (ja) | 2006-10-16 | 2014-02-05 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ブラジキニン１受容体モジュレータとしての置換されたスルホンアミド誘導体 |
| DE102006050672A1 (de) * | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
| DE102007010815B3 (de) | 2007-03-06 | 2008-07-31 | Curacyte Discovery Gmbh | Meta-substituierte Phenylsulfonylamide sekundärer Aminosäureamide, ihre Herstellung und Verwendung als Hemmstoffe der Matriptase |
| JP5260976B2 (ja) * | 2008-02-08 | 2013-08-14 | 東ソー株式会社 | 血液凝固第ｖｉｉｉ因子ｃ２ドメインタンパク質の製造方法 |
| US8912176B2 (en) | 2009-02-02 | 2014-12-16 | Evotec Ag | Azetidines as histamine H3 receptor antagonists |
| KR20120058468A (ko) | 2009-05-18 | 2012-06-07 | 오리온 코포레이션 | 프로테아제 억제제 |
| US8921319B2 (en) | 2010-07-07 | 2014-12-30 | The Medicines Company (Leipzig) Gmbh | Serine protease inhibitors |
| EP2655399B1 (en) | 2010-12-21 | 2017-09-27 | The Medicines Company (Leipzig) GmbH | Trypsin-like serine protease inhibitors, their preparation and use as selective inhibitors of the clotting factors iia and xa |
| WO2012162828A1 (en) * | 2011-06-02 | 2012-12-06 | Socpra Sciences Santé Et Humaines S.E.C. | Matriptase inhibitors and uses thereof against orthomyxoviridae infections |
| US11130780B2 (en) | 2015-03-09 | 2021-09-28 | Washington University | Inhibitors of growth factor activation enzymes |
| KR102704242B1 (ko) | 2017-06-20 | 2024-09-09 | 임브리아 파마슈티칼스, 인크. | 심장 대사의 효율을 증가시키기 위한 조성물 및 방법 |
| EP3654968B1 (en) | 2017-07-17 | 2023-08-16 | Merck Sharp & Dohme LLC | Metallo-beta-lactamase inhibitors and methods of use thereof |
| WO2020081361A1 (en) | 2018-10-17 | 2020-04-23 | Imbria Pharmaceuticals, Inc. | Methods of treating rheumatic diseases using trimetazidine-based compounds |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3942114C2 (de) * | 1988-12-26 | 1997-09-04 | Hiroyoshi Hidaka | Verbindungen mit einer Wirkung für eine gleichmäßige Gefäßmuskelentspannung und pharmazeutische Zusammensetzung, die diese enthält |
| WO1992008709A1 (de) | 1990-11-15 | 1992-05-29 | Pentapharm Ag | Meta-substituierte phenylalanin-derivate |
| US5607937A (en) * | 1993-02-10 | 1997-03-04 | Pentapharm Ag | Piperazides of substituted phenylalanine derivatives as thrombin inhibitors |
| CH689611A5 (de) | 1995-03-01 | 1999-07-15 | Pentapharm Ag | Urokinase-Inhibitoren. |
| EP1264828B1 (de) * | 1998-07-20 | 2004-04-14 | Wilex AG | Urokinase-Inhibitoren |
| EP1114024B1 (de) | 1998-09-18 | 2002-11-27 | Pentapharm A.G. | Urokinase-inhibitoren |
| US6797504B1 (en) | 2000-09-08 | 2004-09-28 | Dendreon San Diego Llc | Inhibitors of serine protease activity of matriptase or MTSP1 |
| EP1355637A2 (en) | 2000-06-21 | 2003-10-29 | Georgetown University Medical Center | Inhibitors of matriptase for the treatment of cancer |
| AU2003206945A1 (en) * | 2002-02-22 | 2003-09-09 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Use of proteinase inhibitors in the treatment of autoimmune diseases |
| DE10322191B4 (de) * | 2003-05-16 | 2014-02-27 | The Medicines Company (Leipzig) Gmbh | N-sulfonylierte Aminosäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
-
2003
- 2003-05-16 DE DE10322191.3A patent/DE10322191B4/de not_active Expired - Fee Related
-
2004
- 2004-05-17 EP EP04733311A patent/EP1651597A2/de not_active Withdrawn
- 2004-05-17 US US10/555,821 patent/US7772251B2/en not_active Expired - Fee Related
- 2004-05-17 AU AU2004238558A patent/AU2004238558A1/en not_active Abandoned
- 2004-05-17 CA CA2525886A patent/CA2525886C/en not_active Expired - Fee Related
- 2004-05-17 WO PCT/EP2004/005291 patent/WO2004101507A2/de not_active Ceased
- 2004-05-17 EP EP10013067A patent/EP2316830A3/de not_active Withdrawn
- 2004-05-17 JP JP2006529848A patent/JP4653100B2/ja not_active Expired - Fee Related
-
2010
- 2010-07-01 US US12/829,185 patent/US20110002992A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7772251B2 (en) | 2010-08-10 |
| WO2004101507A3 (de) | 2006-03-23 |
| CA2525886C (en) | 2013-01-08 |
| JP2007500734A (ja) | 2007-01-18 |
| EP2316830A2 (de) | 2011-05-04 |
| JP4653100B2 (ja) | 2011-03-16 |
| US20110002992A1 (en) | 2011-01-06 |
| WO2004101507A2 (de) | 2004-11-25 |
| EP1651597A2 (de) | 2006-05-03 |
| DE10322191B4 (de) | 2014-02-27 |
| EP2316830A3 (de) | 2011-08-17 |
| US20070055065A1 (en) | 2007-03-08 |
| CA2525886A1 (en) | 2004-11-25 |
| DE10322191A1 (de) | 2004-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |