AU2004231122B2 - Juvenile hemochromatosis gene (HFE2A), expression products and uses thereof - Google Patents
Juvenile hemochromatosis gene (HFE2A), expression products and uses thereof Download PDFInfo
- Publication number
- AU2004231122B2 AU2004231122B2 AU2004231122A AU2004231122A AU2004231122B2 AU 2004231122 B2 AU2004231122 B2 AU 2004231122B2 AU 2004231122 A AU2004231122 A AU 2004231122A AU 2004231122 A AU2004231122 A AU 2004231122A AU 2004231122 B2 AU2004231122 B2 AU 2004231122B2
- Authority
- AU
- Australia
- Prior art keywords
- hfe2a
- cell
- polypeptide
- seq
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 108090000623 proteins and genes Proteins 0.000 title claims description 271
- 230000014509 gene expression Effects 0.000 title claims description 61
- 201000000361 Hemochromatosis type 2 Diseases 0.000 title claims description 53
- 102100022816 Hemojuvelin Human genes 0.000 title claims description 34
- 101000756823 Homo sapiens Hemojuvelin Proteins 0.000 title claims description 20
- 201000000386 hemochromatosis type 2A Diseases 0.000 title claims description 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 165
- 229920001184 polypeptide Polymers 0.000 claims description 162
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 162
- 150000001875 compounds Chemical class 0.000 claims description 149
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 131
- 210000004027 cell Anatomy 0.000 claims description 131
- 238000000034 method Methods 0.000 claims description 122
- 230000000694 effects Effects 0.000 claims description 121
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 116
- 239000003795 chemical substances by application Substances 0.000 claims description 78
- 201000010099 disease Diseases 0.000 claims description 78
- 241000282414 Homo sapiens Species 0.000 claims description 72
- 229910052742 iron Inorganic materials 0.000 claims description 65
- 230000010438 iron metabolism Effects 0.000 claims description 61
- 238000012360 testing method Methods 0.000 claims description 56
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 46
- 230000008859 change Effects 0.000 claims description 43
- 239000003814 drug Substances 0.000 claims description 41
- 208000035475 disorder Diseases 0.000 claims description 38
- 239000000203 mixture Substances 0.000 claims description 34
- 208000018565 Hemochromatosis Diseases 0.000 claims description 28
- 239000012634 fragment Substances 0.000 claims description 25
- 241001465754 Metazoa Species 0.000 claims description 23
- 108700008625 Reporter Genes Proteins 0.000 claims description 23
- 108060003558 hepcidin Proteins 0.000 claims description 22
- 102000018511 hepcidin Human genes 0.000 claims description 22
- 229940066919 hepcidin Drugs 0.000 claims description 21
- 230000032258 transport Effects 0.000 claims description 21
- XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims description 20
- 108050008605 Hemojuvelin Proteins 0.000 claims description 16
- 230000007423 decrease Effects 0.000 claims description 15
- 150000001413 amino acids Chemical class 0.000 claims description 14
- 125000003729 nucleotide group Chemical group 0.000 claims description 14
- 239000002773 nucleotide Substances 0.000 claims description 13
- 230000000968 intestinal effect Effects 0.000 claims description 11
- 210000002540 macrophage Anatomy 0.000 claims description 11
- 210000004962 mammalian cell Anatomy 0.000 claims description 11
- 230000002068 genetic effect Effects 0.000 claims description 10
- 206010065973 Iron Overload Diseases 0.000 claims description 8
- 210000003494 hepatocyte Anatomy 0.000 claims description 8
- 210000002363 skeletal muscle cell Anatomy 0.000 claims description 8
- 230000008093 supporting effect Effects 0.000 claims description 8
- 102000053642 Catalytic RNA Human genes 0.000 claims description 7
- 108090000994 Catalytic RNA Proteins 0.000 claims description 7
- 208000007502 anemia Diseases 0.000 claims description 7
- 230000000692 anti-sense effect Effects 0.000 claims description 7
- 108091092562 ribozyme Proteins 0.000 claims description 7
- 208000030760 Anaemia of chronic disease Diseases 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 6
- 239000000556 agonist Substances 0.000 claims description 6
- 208000022400 anemia due to chronic disease Diseases 0.000 claims description 6
- 210000000170 cell membrane Anatomy 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 6
- 210000005229 liver cell Anatomy 0.000 claims description 6
- 239000005557 antagonist Substances 0.000 claims description 5
- 210000000653 nervous system Anatomy 0.000 claims description 5
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 5
- 206010022489 Insulin Resistance Diseases 0.000 claims description 4
- 210000004969 inflammatory cell Anatomy 0.000 claims description 4
- 101150096316 5 gene Proteins 0.000 claims description 3
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 3
- 230000007812 deficiency Effects 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- 230000000366 juvenile effect Effects 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 241000097929 Porphyria Species 0.000 claims description 2
- 208000010642 Porphyrias Diseases 0.000 claims description 2
- 208000002903 Thalassemia Diseases 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims 2
- 102000000213 Hemojuvelin Human genes 0.000 claims 1
- 229910052724 xenon Inorganic materials 0.000 claims 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 description 128
- 238000003556 assay Methods 0.000 description 75
- 230000035772 mutation Effects 0.000 description 53
- 238000013518 transcription Methods 0.000 description 41
- 230000035897 transcription Effects 0.000 description 40
- 108091033319 polynucleotide Proteins 0.000 description 27
- 102000040430 polynucleotide Human genes 0.000 description 27
- 239000002157 polynucleotide Substances 0.000 description 27
- 230000001225 therapeutic effect Effects 0.000 description 27
- 230000004071 biological effect Effects 0.000 description 26
- 229940124597 therapeutic agent Drugs 0.000 description 25
- 238000011282 treatment Methods 0.000 description 23
- 150000007523 nucleic acids Chemical class 0.000 description 22
- 241000699666 Mus <mouse, genus> Species 0.000 description 21
- 241000700159 Rattus Species 0.000 description 20
- 230000000875 corresponding effect Effects 0.000 description 20
- 239000000047 product Substances 0.000 description 18
- 102000017481 Repulsive guidance molecule Human genes 0.000 description 17
- 108050005592 Repulsive guidance molecule Proteins 0.000 description 17
- 102000039446 nucleic acids Human genes 0.000 description 15
- 108020004707 nucleic acids Proteins 0.000 description 15
- 238000007423 screening assay Methods 0.000 description 15
- 108700024394 Exon Proteins 0.000 description 14
- 210000000349 chromosome Anatomy 0.000 description 14
- 239000000284 extract Substances 0.000 description 14
- 230000006870 function Effects 0.000 description 13
- 229930004094 glycosylphosphatidylinositol Natural products 0.000 description 13
- 238000004458 analytical method Methods 0.000 description 12
- 229940079593 drug Drugs 0.000 description 12
- 230000003993 interaction Effects 0.000 description 12
- 108020004999 messenger RNA Proteins 0.000 description 12
- 230000008569 process Effects 0.000 description 12
- 239000000126 substance Substances 0.000 description 12
- 210000001519 tissue Anatomy 0.000 description 12
- 230000014616 translation Effects 0.000 description 12
- 239000002299 complementary DNA Substances 0.000 description 11
- 230000004044 response Effects 0.000 description 11
- 238000012216 screening Methods 0.000 description 11
- 101150065637 Hfe gene Proteins 0.000 description 10
- 208000016286 Iron metabolism disease Diseases 0.000 description 10
- 230000027455 binding Effects 0.000 description 9
- 238000003776 cleavage reaction Methods 0.000 description 9
- 230000018109 developmental process Effects 0.000 description 9
- 239000003446 ligand Substances 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 230000007017 scission Effects 0.000 description 9
- 241000894007 species Species 0.000 description 9
- 238000013519 translation Methods 0.000 description 9
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 8
- 241000282412 Homo Species 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 239000013043 chemical agent Substances 0.000 description 8
- 238000011161 development Methods 0.000 description 8
- 230000004048 modification Effects 0.000 description 8
- 238000012986 modification Methods 0.000 description 8
- 230000002974 pharmacogenomic effect Effects 0.000 description 8
- 108010047303 von Willebrand Factor Proteins 0.000 description 8
- 108020004414 DNA Proteins 0.000 description 7
- 241001441723 Takifugu Species 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 210000004185 liver Anatomy 0.000 description 7
- 229940124606 potential therapeutic agent Drugs 0.000 description 7
- 102000005962 receptors Human genes 0.000 description 7
- 108020003175 receptors Proteins 0.000 description 7
- 102200161372 rs74315323 Human genes 0.000 description 7
- 241000287828 Gallus gallus Species 0.000 description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 108010076504 Protein Sorting Signals Proteins 0.000 description 6
- 238000002866 fluorescence resonance energy transfer Methods 0.000 description 6
- 210000002216 heart Anatomy 0.000 description 6
- 230000004060 metabolic process Effects 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- -1 small molecule organic compounds Chemical class 0.000 description 6
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 5
- 102000048988 Hemochromatosis Human genes 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- 230000004988 N-glycosylation Effects 0.000 description 5
- 238000010171 animal model Methods 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 230000001976 improved effect Effects 0.000 description 5
- 230000036961 partial effect Effects 0.000 description 5
- 238000010791 quenching Methods 0.000 description 5
- 230000002103 transcriptional effect Effects 0.000 description 5
- 239000013598 vector Substances 0.000 description 5
- 102100036537 von Willebrand factor Human genes 0.000 description 5
- 108700028369 Alleles Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 101100468540 Homo sapiens RGMA gene Proteins 0.000 description 4
- 102000004338 Transferrin Human genes 0.000 description 4
- 108090000901 Transferrin Proteins 0.000 description 4
- 102100026143 Transferrin receptor protein 2 Human genes 0.000 description 4
- 230000001594 aberrant effect Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000005194 fractionation Methods 0.000 description 4
- 238000010353 genetic engineering Methods 0.000 description 4
- 102000054766 genetic haplotypes Human genes 0.000 description 4
- 230000000977 initiatory effect Effects 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 210000004379 membrane Anatomy 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000013612 plasmid Substances 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 230000000171 quenching effect Effects 0.000 description 4
- 102220090146 rs370608001 Human genes 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 230000011664 signaling Effects 0.000 description 4
- 238000006467 substitution reaction Methods 0.000 description 4
- 239000012581 transferrin Substances 0.000 description 4
- 238000011144 upstream manufacturing Methods 0.000 description 4
- 229960001134 von willebrand factor Drugs 0.000 description 4
- 108020004705 Codon Proteins 0.000 description 3
- 102000004961 Furin Human genes 0.000 description 3
- 108090001126 Furin Proteins 0.000 description 3
- 101100468539 Gallus gallus RGMA gene Proteins 0.000 description 3
- 101000835086 Homo sapiens Transferrin receptor protein 2 Proteins 0.000 description 3
- 108700026244 Open Reading Frames Proteins 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 210000001185 bone marrow Anatomy 0.000 description 3
- 230000002759 chromosomal effect Effects 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 238000007877 drug screening Methods 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000001415 gene therapy Methods 0.000 description 3
- 230000007614 genetic variation Effects 0.000 description 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 3
- 230000031891 intestinal absorption Effects 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 230000010534 mechanism of action Effects 0.000 description 3
- 229930014626 natural product Natural products 0.000 description 3
- 230000007030 peptide scission Effects 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 102000054765 polymorphisms of proteins Human genes 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 102220000936 rs74315326 Human genes 0.000 description 3
- 238000012163 sequencing technique Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- 101150098072 20 gene Proteins 0.000 description 2
- 101150110188 30 gene Proteins 0.000 description 2
- UWAUSMGZOHPBJJ-UHFFFAOYSA-N 4-nitro-1,2,3-benzoxadiazole Chemical compound [O-][N+](=O)C1=CC=CC2=C1N=NO2 UWAUSMGZOHPBJJ-UHFFFAOYSA-N 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 2
- 208000031229 Cardiomyopathies Diseases 0.000 description 2
- 108010035563 Chloramphenicol O-acetyltransferase Proteins 0.000 description 2
- 241000252212 Danio rerio Species 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 108091060211 Expressed sequence tag Proteins 0.000 description 2
- 206010019280 Heart failures Diseases 0.000 description 2
- 102100036284 Hepcidin Human genes 0.000 description 2
- 101001021253 Homo sapiens Hepcidin Proteins 0.000 description 2
- 101000756808 Homo sapiens Repulsive guidance molecule A Proteins 0.000 description 2
- 101000637813 Homo sapiens Solute carrier family 40 member 1 Proteins 0.000 description 2
- 206010022971 Iron Deficiencies Diseases 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 238000000636 Northern blotting Methods 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 2
- 102000001708 Protein Isoforms Human genes 0.000 description 2
- 102100022813 Repulsive guidance molecule A Human genes 0.000 description 2
- 108091006976 SLC40A1 Proteins 0.000 description 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 230000006793 arrhythmia Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000003915 cell function Effects 0.000 description 2
- 230000030570 cellular localization Effects 0.000 description 2
- 150000005829 chemical entities Chemical class 0.000 description 2
- 239000000287 crude extract Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000002939 deleterious effect Effects 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000007878 drug screening assay Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 102000034356 gene-regulatory proteins Human genes 0.000 description 2
- 108091006104 gene-regulatory proteins Proteins 0.000 description 2
- 201000000354 hemochromatosis type 3 Diseases 0.000 description 2
- 201000000388 hemochromatosis type 4 Diseases 0.000 description 2
- 238000012188 high-throughput screening assay Methods 0.000 description 2
- 230000003054 hormonal effect Effects 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 230000037353 metabolic pathway Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000007923 nasal drop Substances 0.000 description 2
- 229940100662 nasal drops Drugs 0.000 description 2
- 230000003076 paracrine Effects 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 230000004952 protein activity Effects 0.000 description 2
- 238000002731 protein assay Methods 0.000 description 2
- 238000000159 protein binding assay Methods 0.000 description 2
- 108020001580 protein domains Proteins 0.000 description 2
- 230000006916 protein interaction Effects 0.000 description 2
- 238000001273 protein sequence alignment Methods 0.000 description 2
- 230000006337 proteolytic cleavage Effects 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 230000003252 repetitive effect Effects 0.000 description 2
- 102200043342 rs281875266 Human genes 0.000 description 2
- 102200025125 rs641081 Human genes 0.000 description 2
- 102220000935 rs74315324 Human genes 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 210000002027 skeletal muscle Anatomy 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 230000009261 transgenic effect Effects 0.000 description 2
- 101150072531 10 gene Proteins 0.000 description 1
- 201000000359 African iron overload Diseases 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- OMLWNBVRVJYMBQ-YUMQZZPRSA-N Arg-Arg Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O OMLWNBVRVJYMBQ-YUMQZZPRSA-N 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000010667 Carcinoma of liver and intrahepatic biliary tract Diseases 0.000 description 1
- 208000020446 Cardiac disease Diseases 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 108700037009 Congenital atransferrinemia Proteins 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 208000035220 Dyserythropoietic Congenital Anemia Diseases 0.000 description 1
- 102000004533 Endonucleases Human genes 0.000 description 1
- 108010042407 Endonucleases Proteins 0.000 description 1
- 101710190709 Eukaryotic translation initiation factor 4 gamma 2 Proteins 0.000 description 1
- 108700000224 Familial apoceruloplasmin deficiency Proteins 0.000 description 1
- 102000008857 Ferritin Human genes 0.000 description 1
- 108050000784 Ferritin Proteins 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- 206010051283 Fluid imbalance Diseases 0.000 description 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
- 208000013381 GRACILE syndrome Diseases 0.000 description 1
- 208000002705 Glucose Intolerance Diseases 0.000 description 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 1
- 108010007979 Glycocholic Acid Proteins 0.000 description 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
- 206010073069 Hepatic cancer Diseases 0.000 description 1
- 208000002972 Hepatolenticular Degeneration Diseases 0.000 description 1
- 208000033981 Hereditary haemochromatosis Diseases 0.000 description 1
- 101000756805 Homo sapiens Repulsive guidance molecule B Proteins 0.000 description 1
- 208000023105 Huntington disease Diseases 0.000 description 1
- 208000028958 Hyperferritinemia Diseases 0.000 description 1
- 206010058359 Hypogonadism Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 108091092195 Intron Proteins 0.000 description 1
- 108091006975 Iron transporters Proteins 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 239000005089 Luciferase Substances 0.000 description 1
- 206010027540 Microcytosis Diseases 0.000 description 1
- 108091092878 Microsatellite Proteins 0.000 description 1
- 102100027891 Mitochondrial chaperone BCS1 Human genes 0.000 description 1
- 108091061960 Naked DNA Proteins 0.000 description 1
- 102100021867 Natural resistance-associated macrophage protein 2 Human genes 0.000 description 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 description 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 206010029783 Normochromic normocytic anaemia Diseases 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 230000004989 O-glycosylation Effects 0.000 description 1
- 241000282579 Pan Species 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 241000232971 Passer domesticus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 1
- 241001482237 Pica Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 201000010273 Porphyria Cutanea Tarda Diseases 0.000 description 1
- 206010036186 Porphyria non-acute Diseases 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 230000010799 Receptor Interactions Effects 0.000 description 1
- 102100022814 Repulsive guidance molecule B Human genes 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 108091006618 SLC11A2 Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102100032008 Solute carrier family 40 member 1 Human genes 0.000 description 1
- 102000011971 Sphingomyelin Phosphodiesterase Human genes 0.000 description 1
- 108010061312 Sphingomyelin Phosphodiesterase Proteins 0.000 description 1
- 241001441722 Takifugu rubripes Species 0.000 description 1
- 101150050472 Tfr2 gene Proteins 0.000 description 1
- 206010043391 Thalassaemia beta Diseases 0.000 description 1
- 108700009124 Transcription Initiation Site Proteins 0.000 description 1
- 108010033576 Transferrin Receptors Proteins 0.000 description 1
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 description 1
- 101710132062 Transitional endoplasmic reticulum ATPase Proteins 0.000 description 1
- 108091023045 Untranslated Region Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000018839 Wilson disease Diseases 0.000 description 1
- 241000269370 Xenopus <genus> Species 0.000 description 1
- 241001433070 Xiphoides Species 0.000 description 1
- MMWCIQZXVOZEGG-HOZKJCLWSA-N [(1S,2R,3S,4S,5R,6S)-2,3,5-trihydroxy-4,6-diphosphonooxycyclohexyl] dihydrogen phosphate Chemical compound O[C@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]1OP(O)(O)=O MMWCIQZXVOZEGG-HOZKJCLWSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 208000037919 acquired disease Diseases 0.000 description 1
- 230000009056 active transport Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 201000006288 alpha thalassemia Diseases 0.000 description 1
- 230000001668 ameliorated effect Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 108010068380 arginylarginine Proteins 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- 101150036080 at gene Proteins 0.000 description 1
- 201000007867 atransferrinemia Diseases 0.000 description 1
- 230000001746 atrial effect Effects 0.000 description 1
- 230000003376 axonal effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 201000005008 bacterial sepsis Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 208000005980 beta thalassemia Diseases 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 238000002306 biochemical method Methods 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 235000010633 broth Nutrition 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000000837 carbohydrate group Chemical group 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 238000000423 cell based assay Methods 0.000 description 1
- 230000023402 cell communication Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000002701 cell growth assay Methods 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 238000003570 cell viability assay Methods 0.000 description 1
- 230000017455 cell-cell adhesion Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 238000000749 co-immunoprecipitation Methods 0.000 description 1
- 201000010989 colorectal carcinoma Diseases 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 239000003636 conditioned culture medium Substances 0.000 description 1
- 238000001218 confocal laser scanning microscopy Methods 0.000 description 1
- 201000004440 congenital dyserythropoietic anemia Diseases 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 210000001100 crypt cell Anatomy 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 208000036654 deficiency anemia Diseases 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- KXGVEGMKQFWNSR-LLQZFEROSA-M deoxycholate Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-M 0.000 description 1
- 229940009976 deoxycholate Drugs 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000014155 detection of activity Effects 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000006471 dimerization reaction Methods 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 230000036267 drug metabolism Effects 0.000 description 1
- 239000003596 drug target Substances 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000010437 erythropoiesis Effects 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 239000005090 green fluorescent protein Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 210000002837 heart atrium Anatomy 0.000 description 1
- 210000002064 heart cell Anatomy 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 201000000391 hemochromatosis type 1 Diseases 0.000 description 1
- 201000000357 hemochromatosis type 2B Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 208000006278 hypochromic anemia Diseases 0.000 description 1
- 208000009300 hypochromic microcytic anemia Diseases 0.000 description 1
- 201000003368 hypogonadotropic hypogonadism Diseases 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000126 in silico method Methods 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 238000007914 intraventricular administration Methods 0.000 description 1
- 238000001155 isoelectric focusing Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 125000003473 lipid group Chemical group 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 201000002250 liver carcinoma Diseases 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 210000001767 medulla oblongata Anatomy 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000000869 mutational effect Effects 0.000 description 1
- 210000000107 myocyte Anatomy 0.000 description 1
- 230000009707 neogenesis Effects 0.000 description 1
- 210000003061 neural cell Anatomy 0.000 description 1
- 230000003988 neural development Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000007472 neurodevelopment Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 108091027963 non-coding RNA Proteins 0.000 description 1
- 102000042567 non-coding RNA Human genes 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 208000037233 normocytic anemia Diseases 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 230000001323 posttranslational effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 238000002005 protein protein interaction detection Methods 0.000 description 1
- 238000000734 protein sequencing Methods 0.000 description 1
- 238000002762 protein-protein interaction assay Methods 0.000 description 1
- 230000004850 protein–protein interaction Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 201000003456 pulmonary hemosiderosis Diseases 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000003156 radioimmunoprecipitation Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 210000005245 right atrium Anatomy 0.000 description 1
- 102220170873 rs113227277 Human genes 0.000 description 1
- 102220313078 rs139401358 Human genes 0.000 description 1
- 102220339298 rs1554375599 Human genes 0.000 description 1
- 102200071191 rs1799945 Human genes 0.000 description 1
- 102220102840 rs748783182 Human genes 0.000 description 1
- 102200161373 rs7540883 Human genes 0.000 description 1
- 102220222811 rs779445240 Human genes 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000003497 sciatic nerve Anatomy 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 208000031162 sideroblastic anemia Diseases 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001578 tight junction Anatomy 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
- 210000002417 xiphoid bone Anatomy 0.000 description 1
- 238000001086 yeast two-hybrid system Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2010202722A AU2010202722B2 (en) | 2003-04-15 | 2010-06-29 | Juvenile hemochromatosis gene (HFE2A), expression products and uses thereof |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46286703P | 2003-04-15 | 2003-04-15 | |
| US60/462,867 | 2003-04-15 | ||
| US48860703P | 2003-07-18 | 2003-07-18 | |
| US60/488,607 | 2003-07-18 | ||
| US49845803P | 2003-08-28 | 2003-08-28 | |
| US60/498,458 | 2003-08-28 | ||
| PCT/CA2004/000522 WO2004092405A2 (en) | 2003-04-15 | 2004-04-08 | Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010202722A Division AU2010202722B2 (en) | 2003-04-15 | 2010-06-29 | Juvenile hemochromatosis gene (HFE2A), expression products and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2004231122A1 AU2004231122A1 (en) | 2004-10-28 |
| AU2004231122B2 true AU2004231122B2 (en) | 2010-04-08 |
Family
ID=33303911
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2004231122A Ceased AU2004231122B2 (en) | 2003-04-15 | 2004-04-08 | Juvenile hemochromatosis gene (HFE2A), expression products and uses thereof |
| AU2010202722A Ceased AU2010202722B2 (en) | 2003-04-15 | 2010-06-29 | Juvenile hemochromatosis gene (HFE2A), expression products and uses thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010202722A Ceased AU2010202722B2 (en) | 2003-04-15 | 2010-06-29 | Juvenile hemochromatosis gene (HFE2A), expression products and uses thereof |
Country Status (6)
| Country | Link |
|---|---|
| US (7) | US20070166711A1 (enExample) |
| EP (2) | EP1618131A2 (enExample) |
| JP (1) | JP2006523440A (enExample) |
| AU (2) | AU2004231122B2 (enExample) |
| CA (1) | CA2522680A1 (enExample) |
| WO (1) | WO2004092405A2 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7981420B2 (en) | 2000-12-22 | 2011-07-19 | Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. | Therapeutic use of antibodies directed against repulsive guidance molecule (RGM) |
| WO2003089608A2 (en) | 2002-04-18 | 2003-10-30 | The General Hospital Corporation | Drg11-responsive (dragon) gene family |
| US20070166711A1 (en) | 2003-04-15 | 2007-07-19 | Samuels Mark E | Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof |
| WO2006008182A1 (en) * | 2004-07-23 | 2006-01-26 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | RGMc MODIFIED TRANSGENIC ANIMALS |
| ES2547866T3 (es) | 2005-02-16 | 2015-10-09 | The General Hospital Corporation | Uso de proteínas de fusión de hemojuvelina para regular el metabolismo del hierro mediado por hepcidina |
| US7534764B2 (en) * | 2005-06-29 | 2009-05-19 | The Regents Of The University Of California | Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin |
| WO2007039256A2 (de) * | 2005-09-30 | 2007-04-12 | Abbott Gmbh & Co. Kg | Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung |
| WO2008079877A2 (en) * | 2006-12-22 | 2008-07-03 | Xenon Pharmaceuticals Inc. | Compositions and methods for the diagnosis and treatment of iron-related disorders |
| US8629250B2 (en) * | 2007-02-02 | 2014-01-14 | Amgen Inc. | Hepcidin, hepcidin antagonists and methods of use |
| US8895002B2 (en) | 2007-04-09 | 2014-11-25 | The General Hospital Corporation | Hemojuvelin fusion proteins and uses thereof |
| EP2033971A1 (de) * | 2007-09-06 | 2009-03-11 | Abbott GmbH & Co. KG | Bone Morphogenetic Protein (BMP)-bindende Domänen von Proteinen der Repulsive Guidance Molecule (RGM) Proteinfamilie und funktionale Fragmente davon sowie deren Verwendung |
| JP2010540534A (ja) | 2007-09-28 | 2010-12-24 | イントレキソン コーポレーション | 生体治療分子の発現のための治療遺伝子スイッチ構築物およびバイオリアクター、ならびにその使用 |
| US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
| US20100068737A1 (en) * | 2008-09-16 | 2010-03-18 | University Of Tennessee Research Foundation | Enzyme-linked Immunosorbent Assay (ELISA) for Canine Hepcidin |
| AU2009322260B2 (en) | 2008-12-05 | 2013-09-12 | The Regents Of The University Of California | Mini-hepcidin peptides and methods of using thereof |
| SG172789A1 (en) | 2009-02-11 | 2011-08-29 | Novozymes Biopharma Dk As | Albumin variants and conjugates |
| RU2607374C2 (ru) | 2009-10-30 | 2017-01-10 | Новозаймс Байофарма Дк А/С | Варианты альбумина |
| BR112012013734A2 (pt) | 2009-12-08 | 2017-01-10 | Abbott Gmbh & Co Kg | anticorpos monoclonais contra a proteína rgm a para uso no tratamento da degeneração da camada de fibras nervosas da retina. |
| US10233228B2 (en) | 2010-04-09 | 2019-03-19 | Albumedix Ltd | Albumin derivatives and variants |
| AU2012251919B2 (en) | 2011-01-19 | 2016-12-15 | Ferrumax Pharmaceuticals, Inc. | Compositions for regulating iron homeostasis and methods of using same |
| US20140315817A1 (en) | 2011-11-18 | 2014-10-23 | Eleven Biotherapeutics, Inc. | Variant serum albumin with improved half-life and other properties |
| HK1199892A1 (en) | 2011-12-09 | 2015-07-24 | The Regents Of The University Of California | Modified mini-hepcidin peptides and methods of using thereof |
| SG11201404263TA (en) | 2012-01-27 | 2014-08-28 | Abbvie Deutschland | Composition and method for diagnosis and treatment of diseases associated with neurite degeneration |
| MX2014010278A (es) | 2012-03-16 | 2015-03-05 | Novozymes Biopharma Dk As | Variantes de albumina. |
| CN105452290A (zh) | 2012-11-08 | 2016-03-30 | 诺维信生物制药丹麦公司 | 白蛋白变体 |
| EP4091624A1 (en) | 2013-03-15 | 2022-11-23 | Protagonist Therapeutics, Inc. | Hepcidin analogues and uses thereof |
| CA2949215C (en) | 2014-05-16 | 2023-03-14 | Protagonist Therapeutics, Inc. | .alpha.4.beta.7 integrin thioether peptide antagonists |
| EP4378536A3 (en) | 2014-07-17 | 2024-10-09 | Protagonist Therapeutics, Inc. | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases |
| SG11201702553RA (en) | 2014-10-01 | 2017-04-27 | Protagonist Therapeutics Inc | NOVEL α4β7 PEPTIDE MONOMER AND DIMER ANTAGONISTS |
| EP3201217A4 (en) | 2014-10-01 | 2018-07-18 | Protagonist Therapeutics Inc. | Novel cyclic monomer and dimer peptides having integrin antagonist activity |
| US20170362292A1 (en) | 2014-12-29 | 2017-12-21 | The Regents Of The University Of California | S-Alkylated Hepcidin Peptides and Methods of Making and Using Thereof |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| CA2989966C (en) | 2015-08-20 | 2024-04-30 | Albumedix A/S | Albumin variants and conjugates |
| WO2017117411A1 (en) | 2015-12-30 | 2017-07-06 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| CN115925790A (zh) | 2016-03-23 | 2023-04-07 | 领导医疗有限公司 | 用于合成α4β7肽拮抗剂的方法 |
| WO2018128828A1 (en) | 2016-12-23 | 2018-07-12 | Bayer Healthcare Llc | Novel hepcidin mimetics and uses thereof |
| EP4092038A1 (en) | 2017-09-11 | 2022-11-23 | Protagonist Therapeutics, Inc. | Opioid agonist peptides and uses thereof |
| CA3089868A1 (en) | 2018-02-08 | 2019-08-15 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| US20210196823A1 (en) | 2018-06-08 | 2021-07-01 | Pfizer Inc. | Methods of Treating Metabolic Disease |
| KR20220044277A (ko) | 2019-07-10 | 2022-04-07 | 프로타고니스트 테라퓨틱스, 인코포레이티드 | 인터루킨-23 수용체의 펩티드 억제제 및 염증성 질환을 치료하기 위한 이의 용도 |
| CN114761013A (zh) | 2019-09-27 | 2022-07-15 | 迪斯克医药公司 | 治疗骨髓纤维化和相关病症的方法 |
| WO2021146454A1 (en) | 2020-01-15 | 2021-07-22 | Janssen Biotech, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| WO2021146441A1 (en) | 2020-01-15 | 2021-07-22 | Janssen Biotech, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| KR20230012539A (ko) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체 |
| EP4247403A4 (en) | 2020-11-20 | 2024-12-11 | JANSSEN Pharmaceutica NV | COMPOSITIONS OF PEPTIDE INHIBITORS OF THE INTERLEUKIN-23 RECEPTOR |
| JP2024525732A (ja) | 2021-07-14 | 2024-07-12 | ヤンセン バイオテツク，インコーポレーテツド | インターロイキン－２３受容体の脂質化ペプチド阻害剤 |
| AU2022394462A1 (en) | 2021-11-17 | 2024-05-02 | AbbVie Deutschland GmbH & Co. KG | Methods for treating anemia of kidney disease |
| WO2024170505A1 (en) | 2023-02-13 | 2024-08-22 | Institut National de la Santé et de la Recherche Médicale | Methods of treatment of iron overload associated diseases |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001074901A2 (en) * | 2000-03-31 | 2001-10-11 | Scios Inc. | Polynucleotides and polypeptides, their use in diagnosis and treatment of cardiac, renal or inflammary disease |
| WO2002051438A2 (en) * | 2000-12-22 | 2002-07-04 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of repulsive guidance molecule (rgm) and its modulators |
| WO2002074961A1 (en) * | 2001-03-15 | 2002-09-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69532857T2 (de) | 1994-10-27 | 2005-04-28 | Genentech Inc., San Francisco | Neurotrophischer AL-1 Faktor, einer Ligand verwandt mit dem EPH Tyrosine Kinase Receptor |
| US5994315A (en) * | 1995-06-07 | 1999-11-30 | East Carolina University | Low adenosine agent, composition, kit and method for treatment of airway disease |
| US6319906B1 (en) * | 1996-12-31 | 2001-11-20 | Isis Pharmaceuticals | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
| US5877309A (en) * | 1997-08-13 | 1999-03-02 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotides against JNK |
| JP2003518364A (ja) | 1999-05-28 | 2003-06-10 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | 乳癌、胃癌および前立腺癌関連抗原ならびにそれらの使用 |
| US6180353B1 (en) * | 2000-01-24 | 2001-01-30 | Isis Pharmaceuticals Inc. | Antisense modulation of daxx expression |
| JP2003135075A (ja) * | 2001-11-05 | 2003-05-13 | Research Association For Biotechnology | 新規な全長ｃＤＮＡ |
| WO2003089608A2 (en) * | 2002-04-18 | 2003-10-30 | The General Hospital Corporation | Drg11-responsive (dragon) gene family |
| US7250496B2 (en) * | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| US20070166711A1 (en) | 2003-04-15 | 2007-07-19 | Samuels Mark E | Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof |
| US7534764B2 (en) * | 2005-06-29 | 2009-05-19 | The Regents Of The University Of California | Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin |
-
2004
- 2004-04-08 US US10/552,158 patent/US20070166711A1/en not_active Abandoned
- 2004-04-08 AU AU2004231122A patent/AU2004231122B2/en not_active Ceased
- 2004-04-08 EP EP04726398A patent/EP1618131A2/en not_active Withdrawn
- 2004-04-08 CA CA002522680A patent/CA2522680A1/en not_active Abandoned
- 2004-04-08 WO PCT/CA2004/000522 patent/WO2004092405A2/en not_active Ceased
- 2004-04-08 EP EP08154618A patent/EP2006298A3/en not_active Withdrawn
- 2004-04-08 JP JP2006504100A patent/JP2006523440A/ja active Pending
-
2005
- 2005-08-04 US US11/197,710 patent/US7511018B2/en not_active Expired - Fee Related
-
2009
- 2009-02-09 US US12/322,931 patent/US7893206B2/en not_active Expired - Fee Related
- 2009-06-19 US US12/456,667 patent/US8080651B2/en not_active Expired - Fee Related
- 2009-09-15 US US12/584,947 patent/US20100068803A1/en not_active Abandoned
-
2010
- 2010-06-29 AU AU2010202722A patent/AU2010202722B2/en not_active Ceased
-
2011
- 2011-01-24 US US12/931,068 patent/US8252578B2/en not_active Expired - Fee Related
-
2012
- 2012-07-19 US US13/553,321 patent/US8507435B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001074901A2 (en) * | 2000-03-31 | 2001-10-11 | Scios Inc. | Polynucleotides and polypeptides, their use in diagnosis and treatment of cardiac, renal or inflammary disease |
| WO2002051438A2 (en) * | 2000-12-22 | 2002-07-04 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of repulsive guidance molecule (rgm) and its modulators |
| WO2002074961A1 (en) * | 2001-03-15 | 2002-09-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
Non-Patent Citations (9)
| Title |
|---|
| AFANASSIEV, V. et al., Mutation Res., 2000, vol 464, pages 297-308 * |
| GENBANK Accession no. AAM95449 * |
| GENBANK Accession no. BAC05248 * |
| GENBANK Accession no. BAC11285 * |
| GONZALEZ, J. et al., Curr. Opin. Biotech., 1998, vol. 9, pages 624-631 * |
| HERTZBERG, R. P. et al., Curr. Opin. Chem. Biol., 2000, vol. 4, pages 445-451 * |
| MATTHEAKIS, L. C. et al., Chem. Biol., 1999, vol. 6, pages 835-844 * |
| PENDER, B. A. et al., J. Med. Chem., 2001, vol. 44, pages 36-46 * |
| TAUPIN, J-L. et al., J. Immunol. Meth., 2001, vol. 256, pages 77-87 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2006298A3 (en) | 2009-04-22 |
| US20070166711A1 (en) | 2007-07-19 |
| US20120301485A1 (en) | 2012-11-29 |
| US7511018B2 (en) | 2009-03-31 |
| US20100041139A1 (en) | 2010-02-18 |
| US8080651B2 (en) | 2011-12-20 |
| WO2004092405A3 (en) | 2005-05-06 |
| EP1618131A2 (en) | 2006-01-25 |
| US20060073497A1 (en) | 2006-04-06 |
| US20090227502A1 (en) | 2009-09-10 |
| WO2004092405A2 (en) | 2004-10-28 |
| AU2010202722A1 (en) | 2010-07-15 |
| CA2522680A1 (en) | 2004-10-28 |
| US8252578B2 (en) | 2012-08-28 |
| US20110212107A1 (en) | 2011-09-01 |
| AU2004231122A1 (en) | 2004-10-28 |
| US7893206B2 (en) | 2011-02-22 |
| US20100068803A1 (en) | 2010-03-18 |
| AU2010202722B2 (en) | 2012-12-20 |
| EP2006298A2 (en) | 2008-12-24 |
| US8507435B2 (en) | 2013-08-13 |
| JP2006523440A (ja) | 2006-10-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2004231122B2 (en) | Juvenile hemochromatosis gene (HFE2A), expression products and uses thereof | |
| US9086420B2 (en) | Methods for identifying analgesic agents | |
| US20030054531A1 (en) | Human stroke gene | |
| JP2006508642A (ja) | 脂肪の蓄積を減少させる方法と、関連疾患を治療するための方法 | |
| US20080199480A1 (en) | Methods for Identifying Risk of Type II Diabetes and Treatments Thereof | |
| AU2790701A (en) | Methods for diagnosing and treating heart disease | |
| US20160166541A1 (en) | Methods For Identifying Analgesic Agents | |
| AU767718B2 (en) | Novel mutations in the (FREAC3) gene for diagnosis and prognosis of glaucoma and anterior segment dysgenesis | |
| EP1721008B1 (en) | Diagnostic and therapeutic use of mal2 gene and protein for neurodegenerative diseases | |
| JP2006506988A (ja) | 染色体５ｑ３５に位置したヒトＩＩ型糖尿病遺伝子−ＳＬＩＴ−３ | |
| HK1126792A (en) | Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof | |
| JP2003284573A (ja) | グアノシン三リン酸結合タンパク質共役型の受容体 | |
| WO2003005034A2 (en) | Processes for identifying therapeutic agents useful in treating diseases involving fzd4 gene | |
| US6395488B1 (en) | Cholecystokinin (CCK) gene as a risk factor for smoking in women | |
| WO2004103316A2 (en) | Orp9, a novel therapeutic target for increasing hdl levels | |
| Class et al. | Patent application title: FAM26C POLYMORPHISMS AND USE THEREOF FOR THE DIAGNOSTIC AND TREATMENT OF LATE ONSET ALZHEIMER'S DISEASE Inventors: Philippe Marambaud (Astoria, NY, US) Fabien Campagne (Astoria, NY, US) | |
| EP1551856A2 (en) | Novel therapeutic target for treating vascular diseases, dyslipidemias and related disorders | |
| US20060166207A1 (en) | Hsan II related gene and expression products and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |