AU2004212054A1 - Substituted 3-(benzoylureido)-thiophene derivatives, method for the production and use thereof - Google Patents
Substituted 3-(benzoylureido)-thiophene derivatives, method for the production and use thereof Download PDFInfo
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- AU2004212054A1 AU2004212054A1 AU2004212054A AU2004212054A AU2004212054A1 AU 2004212054 A1 AU2004212054 A1 AU 2004212054A1 AU 2004212054 A AU2004212054 A AU 2004212054A AU 2004212054 A AU2004212054 A AU 2004212054A AU 2004212054 A1 AU2004212054 A1 AU 2004212054A1
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- 238000004519 manufacturing process Methods 0.000 title claims description 3
- WGRIEMJPCBPTBI-UHFFFAOYSA-N n-(thiophen-3-ylcarbamoyl)benzamide Chemical class C1=CSC=C1NC(=O)NC(=O)C1=CC=CC=C1 WGRIEMJPCBPTBI-UHFFFAOYSA-N 0.000 title description 3
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 54
- -1 2 -piperidinyl Chemical group 0.000 claims description 41
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- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 24
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
- C07D333/44—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms attached in position 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10306502A DE10306502B4 (de) | 2003-02-17 | 2003-02-17 | Substituierte 3-(Benzoylureido)-thiophenderivate und sie enthaltende Arzneimittel |
| DE10306502.4 | 2003-02-17 | ||
| PCT/EP2004/000993 WO2004072060A1 (de) | 2003-02-17 | 2004-02-04 | Substituierte 3-(benzoylureido)-thiophenderivate, verfahren zu deren herstellung und deren verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2004212054A1 true AU2004212054A1 (en) | 2004-08-26 |
Family
ID=32841675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2004212054A Abandoned AU2004212054A1 (en) | 2003-02-17 | 2004-02-04 | Substituted 3-(benzoylureido)-thiophene derivatives, method for the production and use thereof |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1597247B1 (https=) |
| JP (1) | JP4589301B2 (https=) |
| KR (1) | KR20050105470A (https=) |
| CN (1) | CN1751036A (https=) |
| AR (1) | AR043179A1 (https=) |
| AT (1) | ATE402160T1 (https=) |
| AU (1) | AU2004212054A1 (https=) |
| BR (1) | BRPI0407552A (https=) |
| CA (1) | CA2516269A1 (https=) |
| CO (1) | CO5690549A2 (https=) |
| DE (2) | DE10306502B4 (https=) |
| HR (1) | HRP20050715A2 (https=) |
| MA (1) | MA27657A1 (https=) |
| MX (1) | MXPA05008331A (https=) |
| NO (1) | NO20054168L (https=) |
| PE (1) | PE20050221A1 (https=) |
| PL (1) | PL376753A1 (https=) |
| RU (1) | RU2005129109A (https=) |
| TW (1) | TW200505892A (https=) |
| WO (1) | WO2004072060A1 (https=) |
| ZA (1) | ZA200505487B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7365061B2 (en) | 2004-11-15 | 2008-04-29 | Bristol-Myers Squibb Company | 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
| WO2006055462A1 (en) | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
| US7223786B2 (en) | 2004-11-15 | 2007-05-29 | Bristol-Myers Squibb Company | 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors |
| WO2006053274A2 (en) | 2004-11-15 | 2006-05-18 | Bristol-Myers Squibb Company | 2-amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
| WO2006113650A1 (en) * | 2005-04-18 | 2006-10-26 | Khan Saeed R | Design and synthesis of novel tubulin polymerization inhibitors: bonzoylphenyluria (bpu) sulfur analogs |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| WO2020261144A1 (en) * | 2019-06-28 | 2020-12-30 | Pfizer Inc. | 5-(thiophen-2-yl)-1h-tetrazole derivatives as bckdk inhibitors useful for treating various diseases |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3034004A1 (de) * | 1980-09-10 | 1982-04-22 | Hoechst Ag, 6000 Frankfurt | Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
| HUT48880A (en) * | 1987-07-20 | 1989-07-28 | Sandoz Ag | Insecticides and acaricides comprising new n-benzoyl-n'-thienyl urea derivative as active ingredient and process for producing the active ingredients |
| DE10116768A1 (de) * | 2001-04-04 | 2002-10-10 | Aventis Pharma Gmbh | Acylphenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| TR200401029T4 (tr) * | 2000-06-09 | 2004-06-21 | Aventis Pharma Deutschland Gmbh | Asilfenil-üre türevleri, imalat yöntemleri ve ilaç maddesi olarak kullanımları |
| PE20021091A1 (es) * | 2001-05-25 | 2003-02-04 | Aventis Pharma Gmbh | Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion |
| DE10215908B4 (de) * | 2002-04-11 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Acyl-3-carboxyphenyl-harnstoffderivate und deren Verwendung als Arzneimittel |
| DE10215907A1 (de) * | 2002-04-11 | 2003-11-06 | Aventis Pharma Gmbh | Acyl-4-carboxyphenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung |
| DE10225635C1 (de) * | 2002-06-07 | 2003-12-24 | Aventis Pharma Gmbh | N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung |
| BR0312593A (pt) * | 2002-07-11 | 2005-04-12 | Aventis Pharma Gmbh | Aciluréias substituìdas por uréia e uretano, processo para a sua produção e sua aplicação |
| RS20050019A (sr) * | 2002-07-12 | 2007-09-21 | Sanofi - Aventis Pharma Deutschland Gmbh., | Heterociklično supstituisani benzoilkarbamidi,postupak za njihovu proizvodnju i njihova primena kao leka |
| DE10246434B4 (de) * | 2002-10-04 | 2005-08-04 | Aventis Pharma Deutschland Gmbh | Carboxyalkoxy-substituierte Acyl-carboxyphenyl-harnstoffderivate und ihre Verwendung als Arzneimittel |
-
2003
- 2003-02-17 DE DE10306502A patent/DE10306502B4/de not_active Expired - Fee Related
-
2004
- 2004-02-04 HR HR20050715A patent/HRP20050715A2/xx not_active Application Discontinuation
- 2004-02-04 KR KR1020057015029A patent/KR20050105470A/ko not_active Withdrawn
- 2004-02-04 CN CNA2004800044004A patent/CN1751036A/zh active Pending
- 2004-02-04 MX MXPA05008331A patent/MXPA05008331A/es not_active Application Discontinuation
- 2004-02-04 RU RU2005129109/04A patent/RU2005129109A/ru not_active Application Discontinuation
- 2004-02-04 JP JP2006501724A patent/JP4589301B2/ja not_active Expired - Fee Related
- 2004-02-04 CA CA002516269A patent/CA2516269A1/en not_active Abandoned
- 2004-02-04 PL PL376753A patent/PL376753A1/pl not_active Application Discontinuation
- 2004-02-04 EP EP04707896A patent/EP1597247B1/de not_active Expired - Lifetime
- 2004-02-04 DE DE502004007668T patent/DE502004007668D1/de not_active Expired - Lifetime
- 2004-02-04 WO PCT/EP2004/000993 patent/WO2004072060A1/de not_active Ceased
- 2004-02-04 AT AT04707896T patent/ATE402160T1/de not_active IP Right Cessation
- 2004-02-04 AU AU2004212054A patent/AU2004212054A1/en not_active Abandoned
- 2004-02-04 BR BRPI0407552-8A patent/BRPI0407552A/pt not_active IP Right Cessation
- 2004-02-13 TW TW093103411A patent/TW200505892A/zh unknown
- 2004-02-13 AR ARP040100457A patent/AR043179A1/es unknown
- 2004-02-17 PE PE2004000163A patent/PE20050221A1/es not_active Application Discontinuation
-
2005
- 2005-07-07 ZA ZA200505487A patent/ZA200505487B/en unknown
- 2005-08-12 CO CO05080324A patent/CO5690549A2/es not_active Application Discontinuation
- 2005-08-16 MA MA28443A patent/MA27657A1/fr unknown
- 2005-09-07 NO NO20054168A patent/NO20054168L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1597247B1 (de) | 2008-07-23 |
| JP4589301B2 (ja) | 2010-12-01 |
| MXPA05008331A (es) | 2005-09-30 |
| JP2006517933A (ja) | 2006-08-03 |
| DE10306502B4 (de) | 2005-03-17 |
| DE502004007668D1 (de) | 2008-09-04 |
| NO20054168D0 (no) | 2005-09-07 |
| DE10306502A1 (de) | 2004-09-09 |
| BRPI0407552A (pt) | 2006-02-14 |
| CO5690549A2 (es) | 2006-10-31 |
| AR043179A1 (es) | 2005-07-20 |
| HRP20050715A2 (en) | 2006-09-30 |
| PE20050221A1 (es) | 2005-04-04 |
| EP1597247A1 (de) | 2005-11-23 |
| ATE402160T1 (de) | 2008-08-15 |
| RU2005129109A (ru) | 2006-01-27 |
| NO20054168L (no) | 2005-11-11 |
| PL376753A1 (pl) | 2006-01-09 |
| MA27657A1 (fr) | 2005-12-01 |
| TW200505892A (en) | 2005-02-16 |
| CA2516269A1 (en) | 2004-08-26 |
| CN1751036A (zh) | 2006-03-22 |
| ZA200505487B (en) | 2006-08-30 |
| KR20050105470A (ko) | 2005-11-04 |
| WO2004072060A1 (de) | 2004-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH Free format text: FORMER APPLICANT(S): AVENTIS PHARMA DEUTSCHLAND GMBH |
|
| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |