AU2003300522A1 - 4-phenyl-pyrimido (4,5-b) indole derivatives - Google Patents

4-phenyl-pyrimido (4,5-b) indole derivatives

Info

Publication number
AU2003300522A1
AU2003300522A1 AU2003300522A AU2003300522A AU2003300522A1 AU 2003300522 A1 AU2003300522 A1 AU 2003300522A1 AU 2003300522 A AU2003300522 A AU 2003300522A AU 2003300522 A AU2003300522 A AU 2003300522A AU 2003300522 A1 AU2003300522 A1 AU 2003300522A1
Authority
AU
Australia
Prior art keywords
pyrimido
phenyl
indole derivatives
indole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003300522A
Other languages
English (en)
Inventor
Kevin B. Bacon
Florian Gantner
Tadashi Inoue
Hiroshi Komura
Tai-Wei Ly
Aiko Muramatsu
Hiromi Okigami
Hiroki Sato
Makoto Shimazaki
Naoki Tsuno
Klaus Urbahns
Nagahiro Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of AU2003300522A1 publication Critical patent/AU2003300522A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003300522A 2002-12-27 2003-12-13 4-phenyl-pyrimido (4,5-b) indole derivatives Abandoned AU2003300522A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02029029 2002-12-27
EP02029029.2 2002-12-27
PCT/EP2003/014194 WO2004058764A1 (fr) 2002-12-27 2003-12-13 Derives 4-phenyl-pyrimido [4,5-b]indoles

Publications (1)

Publication Number Publication Date
AU2003300522A1 true AU2003300522A1 (en) 2004-07-22

Family

ID=32668748

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003300522A Abandoned AU2003300522A1 (en) 2002-12-27 2003-12-13 4-phenyl-pyrimido (4,5-b) indole derivatives

Country Status (2)

Country Link
AU (1) AU2003300522A1 (fr)
WO (1) WO2004058764A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2247558B2 (fr) 2008-02-14 2024-07-03 Eli Lilly and Company Nouveaux agents d'imagerie pour la détection d'une dysfonction neurologique
EP2161271A1 (fr) * 2008-09-08 2010-03-10 Università Degli Studi Di Milano - Bicocca Inhibiteurs d'alpha-carboline de NMP-ALK, RET, et Bcr-Abl
SG195557A1 (en) 2008-10-22 2013-12-30 Genentech Inc Modulation of axon degeneration
MX2012004638A (es) 2009-10-22 2012-07-04 Genentech Inc Modulacion de degeneracion de axones.
CA2829939C (fr) 2011-03-15 2020-10-13 Trius Therapeutics, Inc. Inhibiteurs de la gyrase tricyclique
NZ627188A (en) 2012-01-27 2015-12-24 Univ Montreal Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells
EP2964225B1 (fr) * 2013-03-06 2018-08-08 Allosteros Therapeutics Inc. Inhibiteurs de camkii et leurs utilisations
US9757378B2 (en) * 2013-05-17 2017-09-12 Universite De Montreal Methods to modulate acute myeloid leukemia stem/progenitor cell expansion and/or differentiation
CN106414718A (zh) 2013-06-11 2017-02-15 哈佛学院校长同事会 SC-β细胞以及用于产生其的组合物和方法
CN107074856A (zh) 2014-09-05 2017-08-18 阿略斯泰罗斯医疗公司 CaMKII抑制剂及其用途
PL3194602T3 (pl) * 2014-09-18 2020-07-27 Université de Montréal Związki i sposoby dla wzmocnienia przeniesienia wirusowego genu do ludzkich komórek krwiotwórczych
WO2016100930A1 (fr) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Procédés de production de lymphocytes b dérivés de cellules souches et leurs procédés d'utilisation
WO2016100909A1 (fr) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Procédés de génération de cellules β dérivées de cellules souches et leurs utilisations
WO2016100898A1 (fr) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Protocole de différentiation dirigée in vitro sans sérum pour générer des cellules b dérivées de cellules souches et leurs utilisations
US10828329B2 (en) 2015-06-05 2020-11-10 Hema-Quebec Methods for culturing and/or differentiating hematopoietic stem cells into progenitors and uses thereof
CA3081762A1 (fr) 2017-11-15 2019-05-23 Semma Therapeutics, Inc. Compositions pour la fabrication de cellules d'ilots et procedes d'utilisation
CN111788195B (zh) 2018-01-31 2023-11-21 海帕瑞吉尼克斯股份有限公司 用于促进肝脏再生或减少或预防肝细胞死亡的蛋白激酶mkk4抑制剂
US11731968B2 (en) 2018-06-21 2023-08-22 Heparegenix Gmbh Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
CA3104246A1 (fr) 2018-07-16 2020-01-23 Heparegenix Gmbh Inhibiteurs de proteine kinase permettant de favoriser la regeneration du foie, ou de reduire ou de prevenir la mort des hepatocytes
CA3108275A1 (fr) 2018-08-10 2020-02-13 Vertex Pharmaceuticals Incorporated Differenciation d'ilot derive de cellules souches
WO2020225077A1 (fr) * 2019-05-03 2020-11-12 Idorsia Pharmaceuticals Ltd Dérivés de pyrimido[4,5-b]indole en tant qu'inhibiteurs de pdhk1
WO2021018820A1 (fr) * 2019-07-29 2021-02-04 Heparegenix Gmbh Inhibiteurs de protéine kinase de pyrazolo-pyridine substitués par hétéroaryle pour favoriser la régénération du foie ou réduire ou prévenir la mort des hépatocytes
AU2020409437A1 (en) * 2019-12-18 2022-07-14 Universite De Montreal Modulators of Cullin 3 adaptor KBTBD4 as anti-cancer compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT964865E (pt) * 1997-01-08 2003-06-30 Upjohn Co Aminas triciclicas farmaceuticamente activas
CA2464934A1 (fr) * 2001-10-31 2003-05-08 Bayer Healthcare Ag Derives de pyrimido [4,5-b] indole

Also Published As

Publication number Publication date
WO2004058764A1 (fr) 2004-07-15

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase