AU2003235466C1 - Method for treating arrhythmias - Google Patents
Method for treating arrhythmias Download PDFInfo
- Publication number
- AU2003235466C1 AU2003235466C1 AU2003235466A AU2003235466A AU2003235466C1 AU 2003235466 C1 AU2003235466 C1 AU 2003235466C1 AU 2003235466 A AU2003235466 A AU 2003235466A AU 2003235466 A AU2003235466 A AU 2003235466A AU 2003235466 C1 AU2003235466 C1 AU 2003235466C1
- Authority
- AU
- Australia
- Prior art keywords
- cvt
- optionally substituted
- alkyl
- formula
- esmolol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 238000000034 method Methods 0.000 title claims abstract description 42
- 206010003119 arrhythmia Diseases 0.000 title claims abstract description 30
- 230000006793 arrhythmia Effects 0.000 title claims abstract description 28
- 239000002876 beta blocker Substances 0.000 claims abstract description 43
- 229940097320 beta blocking agent Drugs 0.000 claims abstract description 43
- 229940127291 Calcium channel antagonist Drugs 0.000 claims abstract description 16
- 239000000480 calcium channel blocker Substances 0.000 claims abstract description 16
- 229940097217 cardiac glycoside Drugs 0.000 claims abstract description 16
- 239000002368 cardiac glycoside Substances 0.000 claims abstract description 16
- 229930002534 steroid glycoside Natural products 0.000 claims abstract description 16
- 239000003379 purinergic P1 receptor agonist Substances 0.000 claims abstract description 15
- 229940122614 Adenosine receptor agonist Drugs 0.000 claims abstract description 12
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 claims abstract description 10
- OESBDSFYJMDRJY-BAYCTPFLSA-N (2r,3s,4r,5r)-2-(hydroxymethyl)-5-[6-[[(3r)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diol Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(N[C@H]3COCC3)=C2N=C1 OESBDSFYJMDRJY-BAYCTPFLSA-N 0.000 claims description 68
- -1 3-tetrahydrofuranyl Chemical group 0.000 claims description 58
- 150000001875 compounds Chemical class 0.000 claims description 48
- 125000001072 heteroaryl group Chemical group 0.000 claims description 44
- 229960003745 esmolol Drugs 0.000 claims description 37
- AQNDDEOPVVGCPG-UHFFFAOYSA-N esmolol Chemical compound COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1 AQNDDEOPVVGCPG-UHFFFAOYSA-N 0.000 claims description 37
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims description 26
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- 241000124008 Mammalia Species 0.000 claims description 23
- 125000000623 heterocyclic group Chemical group 0.000 claims description 23
- IZRXENCTXNMAMI-DIJFLQFKSA-N (2s,3s,4r,5r)-2-[(2-fluorophenyl)sulfanylmethyl]-5-[6-[[(1r,2r)-2-hydroxycyclopentyl]amino]purin-9-yl]oxolane-3,4-diol Chemical compound O[C@@H]1CCC[C@H]1NC1=NC=NC2=C1N=CN2[C@H]1[C@H](O)[C@H](O)[C@@H](CSC=2C(=CC=CC=2)F)O1 IZRXENCTXNMAMI-DIJFLQFKSA-N 0.000 claims description 21
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 15
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
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Classifications
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- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US60/373,766 | 2002-04-18 | ||
| PCT/US2003/012043 WO2003088978A1 (en) | 2002-04-18 | 2003-04-18 | Method of treating arrhythmias comprising administration of an a1 adenosine agonist with a beta blocker, calcium channel blocker or a cardiac glycoside |
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| NZ514515A (en) | 1999-03-23 | 2003-11-28 | Global Cardiac Solutions Pty L | Organ arrest, protection and preservation using a potassium channel operator and/or adenosine receptor and a local anaesthetic |
| US6403567B1 (en) | 1999-06-22 | 2002-06-11 | Cv Therapeutics, Inc. | N-pyrazole A2A adenosine receptor agonists |
| USRE47351E1 (en) | 1999-06-22 | 2019-04-16 | Gilead Sciences, Inc. | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists |
| AU2001238665A1 (en) | 2000-02-23 | 2001-09-03 | Cv Therapeutics, Inc. | Method of identifying partial agonists of the a2a receptor |
| US7157440B2 (en) * | 2001-07-13 | 2007-01-02 | Cv Therapeutics, Inc. | Partial and full agonists of A1 adenosine receptors |
| US7713946B2 (en) * | 2002-07-11 | 2010-05-11 | Cv Therapeutics, Inc. | Partial and full agonists A1 adenosine receptors |
| ATE418991T1 (de) * | 2002-04-18 | 2009-01-15 | Cv Therapeutics Inc | Methode zur behandlung von herzrhythmusstörungen mit einem a1 adenosin agonist zusammen mit einem beta blocker |
| US8470801B2 (en) | 2002-07-29 | 2013-06-25 | Gilead Sciences, Inc. | Myocardial perfusion imaging methods and compositions |
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2003
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- 2003-04-18 CN CNA038086999A patent/CN1646142A/zh active Pending
- 2003-04-18 DE DE60325572T patent/DE60325572D1/de not_active Expired - Lifetime
- 2003-04-18 RU RU2004130826/14A patent/RU2332220C2/ru not_active IP Right Cessation
- 2003-04-18 EP EP03724098A patent/EP1494685B1/en not_active Expired - Lifetime
- 2003-04-18 CN CNA2008101711378A patent/CN101385738A/zh active Pending
- 2003-04-18 AU AU2003235466A patent/AU2003235466C1/en not_active Ceased
- 2003-04-18 MX MXPA04010285A patent/MXPA04010285A/es active IP Right Grant
- 2003-04-18 KR KR10-2004-7016764A patent/KR20040106354A/ko not_active Abandoned
- 2003-04-18 US US10/418,654 patent/US7005425B2/en not_active Expired - Fee Related
- 2003-04-18 JP JP2003585730A patent/JP2005530736A/ja active Pending
- 2003-04-18 NZ NZ536001A patent/NZ536001A/en not_active IP Right Cessation
- 2003-04-18 CA CA002482928A patent/CA2482928A1/en not_active Abandoned
- 2003-04-18 ES ES03724098T patent/ES2318129T3/es not_active Expired - Lifetime
- 2003-04-18 WO PCT/US2003/012043 patent/WO2003088978A1/en not_active Ceased
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| ES2318129T3 (es) | 2009-05-01 |
| US20030216349A1 (en) | 2003-11-20 |
| MXPA04010285A (es) | 2005-02-03 |
| JP2005530736A (ja) | 2005-10-13 |
| NZ536001A (en) | 2006-05-26 |
| US20090118221A1 (en) | 2009-05-07 |
| US7479485B2 (en) | 2009-01-20 |
| DE60325572D1 (de) | 2009-02-12 |
| AU2003235466A1 (en) | 2003-11-03 |
| RU2332220C2 (ru) | 2008-08-27 |
| NO20045005L (no) | 2004-11-17 |
| CN101385738A (zh) | 2009-03-18 |
| ATE418991T1 (de) | 2009-01-15 |
| CA2482928A1 (en) | 2003-10-30 |
| US20060052333A1 (en) | 2006-03-09 |
| US7005425B2 (en) | 2006-02-28 |
| EP1494685A1 (en) | 2005-01-12 |
| ZA200408411B (en) | 2006-02-22 |
| RU2004130826A (ru) | 2005-05-10 |
| WO2003088978A1 (en) | 2003-10-30 |
| KR20040106354A (ko) | 2004-12-17 |
| EP1494685B1 (en) | 2008-12-31 |
| IL164652A0 (en) | 2005-12-18 |
| CN1646142A (zh) | 2005-07-27 |
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