AU2003218600C1 - ERBB3 based methods and compositions for treating neoplasms - Google Patents
ERBB3 based methods and compositions for treating neoplasms Download PDFInfo
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- AU2003218600C1 AU2003218600C1 AU2003218600A AU2003218600A AU2003218600C1 AU 2003218600 C1 AU2003218600 C1 AU 2003218600C1 AU 2003218600 A AU2003218600 A AU 2003218600A AU 2003218600 A AU2003218600 A AU 2003218600A AU 2003218600 C1 AU2003218600 C1 AU 2003218600C1
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02116259.X | 2002-03-26 | ||
| CNB02116259XA CN1219882C (zh) | 2002-03-18 | 2002-03-26 | 以erbb－3为基础的用于肿瘤治疗的方法和组合物 |
| PCT/CN2003/000217 WO2003080835A1 (en) | 2002-03-26 | 2003-03-26 | Erbb3 based methods and compositions for treating neoplasms |
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| AU2003218600B2 AU2003218600B2 (en) | 2009-05-21 |
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| EP (2) | EP2400021B1 (OSRAM) |
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| CA (1) | CA2480099C (OSRAM) |
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Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ105799A0 (en) | 1999-06-18 | 1999-07-08 | Victor Chang Cardiac Research Institute, The | Cell growth inhibition |
| MX2008005640A (es) * | 2005-11-02 | 2008-12-09 | Univ Duke | Quimioterapia e inmunoterapia concurrentes. |
| AR056857A1 (es) * | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos |
| US20070190127A1 (en) | 2005-12-30 | 2007-08-16 | Mingdong Zhou | Extended release of neuregulin for improved cardiac function |
| BRPI0808055A2 (pt) * | 2007-02-16 | 2013-07-30 | Merrimack Pharmaceuticals Inc | anticorpo monoclonal isolado ou porÇço do mesmo que se liga ao antÍgeno, composiÇço, Ácido nucleico isolado, vetor de expressço, cÉlula hospedeira, hibridoma, kit, uso de um anticorpo monoclonal isolado ou porÇço do mesmo que se liga ao antÍgeno, mÉtodo para diagnosticar um cÂncer associado com erbb3 em um paciente, e, anticorpo |
| US20090156488A1 (en) * | 2007-09-12 | 2009-06-18 | Zensun (Shanghai) Science & Technology Limited | Use of neuregulin for organ preservation |
| WO2009157919A1 (en) * | 2008-06-23 | 2009-12-30 | Tumor Biology Investment Group, Inc. | SOLUBLE ErbB3 DETECTION, REGULATION AND TREATMENT OF CANCER |
| AU2009281721A1 (en) * | 2008-08-15 | 2010-02-18 | Merrimack Pharmaceuticals, Inc. | Methods and systems for predicting response of cells to a therapeutic agent |
| EP2808339B1 (en) | 2008-11-28 | 2017-02-15 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Neuregulin peptides and their use |
| EP2370093A4 (en) * | 2008-11-28 | 2012-08-29 | Zensun Shanghai Science And Technology Ltd | NEUREGULIN AND CARDIAC STEM CELLS |
| LT2719708T (lt) | 2009-11-13 | 2018-02-12 | Daiichi Sankyo Europe Gmbh | Medžiaga ir būdai, skirti su her-3 susijusių ligų gydymui arba prevencijai |
| MX2012007340A (es) | 2009-12-22 | 2012-08-01 | Roche Glycart Ag | Anticuerpos anti/her3 y usos de los mismos. |
| PL2544680T3 (pl) | 2010-03-11 | 2015-08-31 | Merrimack Pharmaceuticals Inc | Zastosowanie inhibitorów ERBB1 w leczeniu potrójnie ujemnego raka gruczołu sutkowego |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| IT1402149B1 (it) * | 2010-10-04 | 2013-08-28 | Ist Fisioterap Ospitalroma | Uso di un fosfopeptide in grado di bloccare l interazione her3/p85 per il trattamento dei tumori iperesprimenti her2. |
| ITRM20100577A1 (it) * | 2010-11-02 | 2012-05-03 | Takis Srl | Immunoterapia contro il recettore erbb-3 |
| TWI418362B (zh) * | 2010-11-19 | 2013-12-11 | Univ Nat Pingtung Sci & Tech | 溶血性巴斯德桿菌重組外膜脂蛋白e及含此之疫苗組成物 |
| CN103562226A (zh) | 2011-03-11 | 2014-02-05 | 梅里麦克制药股份有限公司 | 使用egfr家族受体的抑制剂来治疗激素难治性乳腺癌 |
| CA2828043A1 (en) | 2011-03-15 | 2012-09-20 | Merrimack Pharmaceuticals, Inc. | Overcoming resistance to erbb pathway inhibitors |
| WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun （Shanghai）Science & Technology Limited | Compositions and methods for treating heart failure |
| EP3608340A1 (en) | 2011-11-23 | 2020-02-12 | Medlmmune, LLC | Binding molecules specific for her3 and uses thereof |
| US9956276B2 (en) * | 2012-01-19 | 2018-05-01 | Duke University | Vaccines against antigens involved in therapy resistance and methods of using same |
| AR094403A1 (es) | 2013-01-11 | 2015-07-29 | Hoffmann La Roche | Terapia de combinación de anticuerpos anti-her3 |
| WO2015048008A2 (en) | 2013-09-24 | 2015-04-02 | Medimmune, Llc | Binding molecules specific for her3 and uses thereof |
| WO2015100459A2 (en) | 2013-12-27 | 2015-07-02 | Merrimack Pharmaceuticals, Inc. | Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies |
| WO2015157634A1 (en) | 2014-04-11 | 2015-10-15 | Kolltan Pharmaceuticals, Inc. | Anti-erbb antibodies and methods of use thereof |
| EP3166646A4 (en) | 2014-07-07 | 2018-03-07 | Duke University | Vaccines against an oncogenic isoform of her2 (erbb2) and methods of using the same |
| WO2016007504A1 (en) | 2014-07-07 | 2016-01-14 | Duke University | Vaccines against an oncogenic isoform of esr1 and methods of using the same |
| WO2016011343A1 (en) * | 2014-07-17 | 2016-01-21 | The Trustees Of The University Of Pennsylvania | Her3 peptides and dendritic cell vaccines |
| US10184006B2 (en) | 2015-06-04 | 2019-01-22 | Merrimack Pharmaceuticals, Inc. | Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors |
| JP2018527286A (ja) * | 2015-07-17 | 2018-09-20 | ブライアン ジェイ ツェルニキＣＺＥＲＮＩＥＣＫＩ， Ｂｒｉａｎ， Ｊ． | 免疫に基づく療法のための、免疫原性ｍｈｃクラスｉｉペプチドの同定 |
| US11090284B2 (en) | 2015-09-02 | 2021-08-17 | The Cleveland Clinic Foundation | Ovarian cancer vaccines |
| WO2017120576A1 (en) | 2016-01-07 | 2017-07-13 | Duke University | Cancer vaccines and methods of delivery |
| CN110167968B (zh) * | 2016-09-15 | 2023-11-28 | 斯图加特大学 | 针对her3的抗原结合蛋白 |
| US11224665B2 (en) | 2016-10-05 | 2022-01-18 | Duke University | Mitochondrial antiviral signaling (MAVS) protein compositions and methods of using the same |
| US10487143B2 (en) | 2016-10-05 | 2019-11-26 | Duke University | Vaccines against HER3 antigens and methods of using the same |
| US11890335B2 (en) * | 2017-09-27 | 2024-02-06 | L2 Diagnostics, Llc | ErbB peptide pharmaceutical and vaccine compositions and therapeutic uses thereof for cancer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991008214A1 (en) * | 1989-12-01 | 1991-06-13 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE463851B (sv) | 1988-09-02 | 1991-02-04 | Amsu Ltd | Komposition foer behandling av erektil dysfunktion via uretra |
| AU645760B2 (en) | 1989-08-04 | 1994-01-27 | Berlex Laboratories, Inc. | C-erbb-2 external domain: GP75 |
| US5578482A (en) | 1990-05-25 | 1996-11-26 | Georgetown University | Ligand growth factors that bind to the erbB-2 receptor protein and induce cellular responses |
| DE4221256C2 (de) | 1992-06-26 | 1997-07-10 | Lancaster Group Ag | Galenische Zusammensetzung für die topische Anwendung |
| US5869305A (en) | 1992-12-04 | 1999-02-09 | The University Of Pittsburgh | Recombinant viral vector system |
| US5741511A (en) | 1995-04-12 | 1998-04-21 | Sam Yang Co., Ltd. | Transdermal drug delivery device for treating erectile dysfunction |
| US5888767A (en) | 1996-11-27 | 1999-03-30 | The Johns Hopkins University School Of Medicine | Method of using a conditionally replicating viral vector to express a gene |
| AU1057097A (en) | 1995-12-22 | 1997-07-17 | Beth Israel Deaconess Medical Center | Localized intravascular delivery of growth factors for promotion of angiogenesis |
| US5736154A (en) | 1996-03-11 | 1998-04-07 | Fuisz Technologies Ltd. | Transdermal delivery system |
| EP1728802A3 (en) | 1996-03-27 | 2006-12-13 | Genentech, Inc. | ErbB3 antibodies |
| US5968511A (en) | 1996-03-27 | 1999-10-19 | Genentech, Inc. | ErbB3 antibodies |
| EP0938556B1 (en) * | 1996-07-12 | 2005-03-09 | Genentech, Inc. | Gamma-heregulin |
| CN100415772C (zh) | 1996-10-18 | 2008-09-03 | 基因技术股份有限公司 | 抗ErbB2抗体 |
| US5981201A (en) | 1997-01-08 | 1999-11-09 | Beth Israel Deaconess Medical Center | Methods of detection and treatment of breast cancer |
| WO1998035036A1 (en) | 1997-02-10 | 1998-08-13 | Genentech, Inc. | Heregulin variants |
| SE9703226D0 (sv) | 1997-09-08 | 1997-09-08 | Astra Ab | New pharmaceutical composition |
| US6197801B1 (en) | 1998-01-14 | 2001-03-06 | Usa Doctors Products, Inc. | Injectable pharmaceutical composition for treatment and reversal of erectile dysfunction |
| US5962274A (en) | 1998-03-13 | 1999-10-05 | Wake Forest University | Viral vector directed to predetermined target cells |
| AUPQ105799A0 (en) | 1999-06-18 | 1999-07-08 | Victor Chang Cardiac Research Institute, The | Cell growth inhibition |
| CA2377665A1 (en) | 1999-07-06 | 2001-01-11 | General Atomics | Methods and compositions for assaying analytes |
| CZ20023748A3 (cs) | 2000-05-15 | 2003-04-16 | Pharmacia Italia S.P.A. | Inhibitory aromatasy a monoklonální anti-HER2 protilátky jako protitumorová činidla |
| EP1283053A1 (en) | 2001-08-09 | 2003-02-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibitors of HER3 activity |
| RU2007135216A (ru) | 2005-02-23 | 2009-03-27 | Мерримак Фармасьютикалз, Инк. (Us) | Биспецифические связывающие агенты для модулирования биологической активности |
| BRPI0808055A2 (pt) | 2007-02-16 | 2013-07-30 | Merrimack Pharmaceuticals Inc | anticorpo monoclonal isolado ou porÇço do mesmo que se liga ao antÍgeno, composiÇço, Ácido nucleico isolado, vetor de expressço, cÉlula hospedeira, hibridoma, kit, uso de um anticorpo monoclonal isolado ou porÇço do mesmo que se liga ao antÍgeno, mÉtodo para diagnosticar um cÂncer associado com erbb3 em um paciente, e, anticorpo |
-
2003
- 2003-03-26 AU AU2003218600A patent/AU2003218600C1/en not_active Ceased
- 2003-03-26 CN CNB038067625A patent/CN100424175C/zh not_active Expired - Fee Related
- 2003-03-26 WO PCT/CN2003/000217 patent/WO2003080835A1/en not_active Ceased
- 2003-03-26 EP EP11178809.7A patent/EP2400021B1/en not_active Expired - Lifetime
- 2003-03-26 CA CA2480099A patent/CA2480099C/en not_active Expired - Fee Related
- 2003-03-26 JP JP2003578561A patent/JP4660094B2/ja not_active Expired - Fee Related
- 2003-03-26 EP EP03711804.9A patent/EP1495123B1/en not_active Expired - Lifetime
- 2003-03-26 US US10/516,759 patent/US7919098B2/en not_active Expired - Lifetime
-
2010
- 2010-04-26 JP JP2010101148A patent/JP5249282B2/ja not_active Expired - Lifetime
-
2011
- 2011-02-25 US US13/035,244 patent/US20110229478A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991008214A1 (en) * | 1989-12-01 | 1991-06-13 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
| US5480968A (en) * | 1989-12-01 | 1996-01-02 | The United States Of America As Represented By The Department Of Health And Human Services | Isolated polypeptide erbB-3, related to the epidermal growth factor receptor and antibody thereto |
| US5820859A (en) * | 1989-12-01 | 1998-10-13 | The United States Of America As Represented By The Department Of Health And Human Services | Method of targeting a therapeutic agent to cells expressing the erb B-3 receptor |
Non-Patent Citations (2)
| Title |
|---|
| Bei R et al. Immune responses to all ErbB family receptors detectable in serum of cancer patients. Oncogene. 18(6):1267-75, 1999. * |
| Kraus MH et al. Proc. Natl. Acad. Sci. U.S.A. 86 (23), 9193-9197, 1989. * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2400021A3 (en) | 2012-03-21 |
| EP2400021B1 (en) | 2016-11-30 |
| US7919098B2 (en) | 2011-04-05 |
| CA2480099A1 (en) | 2003-10-02 |
| JP2010213710A (ja) | 2010-09-30 |
| EP1495123A1 (en) | 2005-01-12 |
| JP2005533488A (ja) | 2005-11-10 |
| JP4660094B2 (ja) | 2011-03-30 |
| CA2480099C (en) | 2019-01-08 |
| CN100424175C (zh) | 2008-10-08 |
| US20110229478A1 (en) | 2011-09-22 |
| EP1495123B1 (en) | 2013-10-30 |
| EP1495123A4 (en) | 2009-06-24 |
| EP2400021A2 (en) | 2011-12-28 |
| AU2003218600A1 (en) | 2003-10-08 |
| WO2003080835A1 (en) | 2003-10-02 |
| CN1650011A (zh) | 2005-08-03 |
| JP5249282B2 (ja) | 2013-07-31 |
| US20080057064A1 (en) | 2008-03-06 |
| AU2003218600B2 (en) | 2009-05-21 |
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