AU2003218162B2 - Mutants of the P4 protein of nontypable haemophilus influenzae with reduced enzymatic activity - Google Patents

Mutants of the P4 protein of nontypable haemophilus influenzae with reduced enzymatic activity Download PDF

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Publication number
AU2003218162B2
AU2003218162B2 AU2003218162A AU2003218162A AU2003218162B2 AU 2003218162 B2 AU2003218162 B2 AU 2003218162B2 AU 2003218162 A AU2003218162 A AU 2003218162A AU 2003218162 A AU2003218162 A AU 2003218162A AU 2003218162 B2 AU2003218162 B2 AU 2003218162B2
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AU
Australia
Prior art keywords
protein
immunogenic composition
wild
variant protein
variant
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2003218162A
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English (en)
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AU2003218162A1 (en
Inventor
Leah D Fletcher
Bruce A Green
Thomas J Reilly
Arnold L Smith
Gary W Zlotnick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
University of Missouri St Louis
Original Assignee
Wyeth Holdings LLC
Wyeth LLC
University of Missouri Columbia
University of Missouri St Louis
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28041949&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2003218162(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Holdings LLC, Wyeth LLC, University of Missouri Columbia, University of Missouri St Louis filed Critical Wyeth Holdings LLC
Publication of AU2003218162A1 publication Critical patent/AU2003218162A1/en
Application granted granted Critical
Publication of AU2003218162B2 publication Critical patent/AU2003218162B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1242—Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2003218162A 2002-03-15 2003-03-13 Mutants of the P4 protein of nontypable haemophilus influenzae with reduced enzymatic activity Ceased AU2003218162B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36468802P 2002-03-15 2002-03-15
US60/364,688 2002-03-15
PCT/US2003/007895 WO2003078453A1 (en) 2002-03-15 2003-03-13 Mutants of the p4 protein of nontypable haemophilus influenzae with reduced enzymatic activity

Publications (2)

Publication Number Publication Date
AU2003218162A1 AU2003218162A1 (en) 2003-09-29
AU2003218162B2 true AU2003218162B2 (en) 2009-10-29

Family

ID=28041949

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003218162A Ceased AU2003218162B2 (en) 2002-03-15 2003-03-13 Mutants of the P4 protein of nontypable haemophilus influenzae with reduced enzymatic activity

Country Status (12)

Country Link
US (2) US7615229B2 (https=)
EP (1) EP1490395A4 (https=)
JP (1) JP2005532789A (https=)
KR (1) KR100981471B1 (https=)
CN (1) CN100593544C (https=)
AU (1) AU2003218162B2 (https=)
BR (1) BR0308441A (https=)
CA (1) CA2479118A1 (https=)
IL (1) IL163988A0 (https=)
MX (1) MXPA04008890A (https=)
NZ (1) NZ535754A (https=)
WO (1) WO2003078453A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012203017B2 (en) * 2003-12-23 2014-10-09 Nationwide Children's Hospital, Inc. Haemophilus Influenzae Type IV Pili
ATE557033T1 (de) 2003-12-23 2012-05-15 Nationwide Children S Hospital Inc Pili von haemophilus influenzae typ iv
EP3311836A1 (en) 2005-04-08 2018-04-25 Wyeth LLC Multivalent pneumococcal polysaccharide-protein conjugate composition
US7709001B2 (en) 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
PE20110072A1 (es) 2005-06-27 2011-02-04 Glaxosmithkline Biolog Sa Composicion inmunogenica
JP4996934B2 (ja) * 2007-02-05 2012-08-08 独立行政法人農業・食品産業技術総合研究機構 組換え型リゾチームの製造法
SG194886A1 (en) * 2011-05-11 2013-12-30 Riesbeck Healthcare Sweden Ab Protein f - a novel haemophilus influenzae adhesin with laminin and vitronectin binding properties
CN113226361A (zh) * 2018-10-15 2021-08-06 代表亚利桑那大学的亚利桑那校董会 疫苗多肽组合物及方法
WO2022056195A1 (en) * 2020-09-10 2022-03-17 The Rochester General Hospital Haemophilus infuluenzae vaccine and methods of use

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Also Published As

Publication number Publication date
AU2003218162A1 (en) 2003-09-29
NZ535754A (en) 2007-01-26
BR0308441A (pt) 2005-01-18
EP1490395A1 (en) 2004-12-29
US20050249746A1 (en) 2005-11-10
EP1490395A4 (en) 2006-06-21
IL163988A0 (en) 2005-12-18
JP2005532789A (ja) 2005-11-04
MXPA04008890A (es) 2005-10-18
US7615229B2 (en) 2009-11-10
US20090148465A1 (en) 2009-06-11
CN1653084A (zh) 2005-08-10
WO2003078453A1 (en) 2003-09-25
US7666626B2 (en) 2010-02-23
CA2479118A1 (en) 2003-09-25
KR20050016307A (ko) 2005-02-21
KR100981471B1 (ko) 2010-09-10
CN100593544C (zh) 2010-03-10

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