AU2002346572A1 - Adenosine a2a receptor antagonists - Google Patents

Adenosine a2a receptor antagonists Download PDF

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Publication number
AU2002346572A1
AU2002346572A1 AU2002346572A AU2002346572A AU2002346572A1 AU 2002346572 A1 AU2002346572 A1 AU 2002346572A1 AU 2002346572 A AU2002346572 A AU 2002346572A AU 2002346572 A AU2002346572 A AU 2002346572A AU 2002346572 A1 AU2002346572 A1 AU 2002346572A1
Authority
AU
Australia
Prior art keywords
mmol
esi
pct
mixture
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002346572A
Other languages
English (en)
Inventor
John P Caldwell
Julius J Matasi
Bernard R Neustadt
Lisa S Silverman
Deen Tulshian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AU2002346572A1 publication Critical patent/AU2002346572A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2002346572A 2001-11-30 2002-11-26 Adenosine a2a receptor antagonists Abandoned AU2002346572A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33429301P 2001-11-30 2001-11-30
US60/334,293 2001-11-30
PCT/US2002/038134 WO2003048164A2 (en) 2001-11-30 2002-11-26 Adenosine a2a receptor antagonists

Publications (1)

Publication Number Publication Date
AU2002346572A1 true AU2002346572A1 (en) 2003-06-17

Family

ID=23306533

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002346572A Abandoned AU2002346572A1 (en) 2001-11-30 2002-11-26 Adenosine a2a receptor antagonists

Country Status (19)

Country Link
US (1) US7041666B2 (US07794700-20100914-C00152.png)
EP (1) EP1453835B1 (US07794700-20100914-C00152.png)
JP (2) JP4284181B2 (US07794700-20100914-C00152.png)
KR (1) KR20050044607A (US07794700-20100914-C00152.png)
CN (1) CN1596258A (US07794700-20100914-C00152.png)
AR (1) AR038366A1 (US07794700-20100914-C00152.png)
AT (1) ATE317844T1 (US07794700-20100914-C00152.png)
AU (1) AU2002346572A1 (US07794700-20100914-C00152.png)
CA (1) CA2468681C (US07794700-20100914-C00152.png)
DE (1) DE60209251T2 (US07794700-20100914-C00152.png)
ES (1) ES2258164T3 (US07794700-20100914-C00152.png)
HK (1) HK1064100A1 (US07794700-20100914-C00152.png)
HU (1) HUP0402270A3 (US07794700-20100914-C00152.png)
IL (1) IL161572A0 (US07794700-20100914-C00152.png)
MX (1) MXPA04005156A (US07794700-20100914-C00152.png)
PE (1) PE20030739A1 (US07794700-20100914-C00152.png)
TW (1) TW200300686A (US07794700-20100914-C00152.png)
WO (1) WO2003048164A2 (US07794700-20100914-C00152.png)
ZA (1) ZA200404160B (US07794700-20100914-C00152.png)

Families Citing this family (28)

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US20060058320A1 (en) * 2002-09-24 2006-03-16 Kyowa Hakko Kogyo Co., Ltd. [1,2,4] Triazolo[1,5-c]pyrimidine derivatives
US20060106040A1 (en) 2002-12-19 2006-05-18 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
DE60335294D1 (de) 2002-12-19 2011-01-20 Schering Corp Dlung des extrapyramidalen syndroms
US20070010522A1 (en) * 2003-04-09 2007-01-11 Chi Vu Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists
AU2004283751B2 (en) * 2003-10-24 2011-05-19 Exelixis, Inc. p70S6 kinase modulators and method of use
AR050926A1 (es) 2004-09-03 2006-12-06 Astrazeneca Ab Derivados de benzamida como inhibidores de la histonadesacetilasa(hdac)
WO2006129626A1 (ja) * 2005-05-30 2006-12-07 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]トリアゾロ[1,5-c]ピリミジン誘導体の製造法
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
ES2405542T3 (es) * 2007-05-24 2013-05-31 Mitsubishi Tanabe Pharma Corporation Agente terapéutico para el infarto cerebral
BRPI0813647A2 (pt) * 2007-06-25 2014-12-23 Neurogen Corp Piperazinil oxoalquil tetrahidro-beta-carbolinas e análogos relacionados
US20100093756A1 (en) * 2008-10-13 2010-04-15 Berbay J Kent HETEROARYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
US20100093764A1 (en) * 2008-10-13 2010-04-15 Devraj Chakravarty AMINES AND SULFOXIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
CA2750783C (en) 2008-11-25 2015-10-13 Nissan Motor Co., Ltd. Electrical conductive member and polymer electrolyte fuel cell using the same
JP5807971B2 (ja) * 2009-04-27 2015-11-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｘｃｒ３受容体アンタゴニスト
WO2011084985A1 (en) 2010-01-07 2011-07-14 Boehringer Ingelheim International Gmbh Cxcr3 receptor antagonists
AU2011306358B2 (en) * 2010-09-24 2014-08-14 Impetis Biosciences Ltd. Fused tricyclic compounds as adenosine receptor antagonist
WO2012127472A1 (en) * 2011-03-22 2012-09-27 Mapi Pharma Ltd. Process and intermediates for the preparation of preladenant and related compounds
DK3611174T3 (da) * 2017-04-07 2022-07-04 Medshine Discovery Inc [1,2,4]triazolo[1,5-c]pyrimidinderivat som a2a-receptorinhibitor
US20190292188A1 (en) * 2018-02-27 2019-09-26 Incyte Corporation Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors
DK3766884T3 (da) * 2018-04-28 2022-03-28 Medshine Discovery Inc Krystalform og salttype af triazolopyrimidinforbindelse og fremstillingsfremgangsmåde dertil
CA3100731A1 (en) * 2018-05-18 2019-11-21 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
CA3105721A1 (en) 2018-07-05 2020-01-09 Incyte Corporation Fused pyrazine derivatives as a2a / a2b inhibitors
AR116315A1 (es) * 2018-09-12 2021-04-21 Dizal Jiangsu Pharmaceutical Co Ltd Compuestos de triazolo-pirimidina y usos de los mismos
WO2020106560A1 (en) * 2018-11-20 2020-05-28 Merck Sharp & Dohme Corp. Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use
CN113015530A (zh) * 2018-11-20 2021-06-22 默沙东公司 取代的氨基三唑并嘧啶和氨基三唑并吡嗪腺苷受体拮抗剂、药物组合物及其用途
MX2021006329A (es) 2018-11-30 2021-08-11 Merck Sharp & Dohme Llc Derivados de amino triazolo quinazolina 9-sustituidos como antagonistas del receptor de adenosina, composiciones farmaceuticas y su uso.
WO2020128036A1 (en) * 2018-12-21 2020-06-25 Ryvu Therapeutics S.A. Modulators of the adenosine a2a receptor
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU622330B2 (en) 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
IT1264901B1 (it) 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
WO1995003806A1 (fr) 1993-07-27 1995-02-09 Kyowa Hakko Kogyo Co., Ltd. Remede contre la maladie de parkinson
IT1277392B1 (it) 1995-07-28 1997-11-10 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina
DE69820866T2 (de) * 1997-03-24 2004-12-30 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE
IT1291372B1 (it) 1997-05-21 1999-01-07 Schering Plough S P A Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
EA200100265A1 (ru) * 1998-09-22 2001-10-22 Киова Хакко Когио Ко., Лтд. Производные [1,2,4]триазоло[1,5-c]пиримидина
RU2315053C2 (ru) 2000-05-26 2008-01-20 Шеринг Корпорейшн ПРОИЗВОДНЫЕ 5-АМИНО-ПИРАЗОЛО-[4,3-е]-1,2,4-ТРИАЗОЛО[1,5-с]ПИРИМИДИНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, ПРИМЕНЕНИЕ И СПОСОБЫ ПОЛУЧЕНИЯ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ
WO2002079204A1 (fr) * 2001-03-28 2002-10-10 Kyowa Hakko Kogyo Co., Ltd. Derive 8-thiazolyl[1,2,4]triazolo[1,5-c]pyrimidine
AU2002352933A1 (en) 2001-11-30 2003-06-17 Schering Corporation [1,2,4]-triazole bicylic adenosine A2a receptor antagonists

Also Published As

Publication number Publication date
US20030212080A1 (en) 2003-11-13
ZA200404160B (en) 2005-04-08
KR20050044607A (ko) 2005-05-12
ATE317844T1 (de) 2006-03-15
PE20030739A1 (es) 2003-08-28
ES2258164T3 (es) 2006-08-16
IL161572A0 (en) 2004-09-27
CA2468681C (en) 2011-01-25
CN1596258A (zh) 2005-03-16
MXPA04005156A (es) 2004-08-11
EP1453835A2 (en) 2004-09-08
JP2008303217A (ja) 2008-12-18
DE60209251D1 (de) 2006-04-20
HUP0402270A3 (en) 2008-09-29
JP4284181B2 (ja) 2009-06-24
WO2003048164A2 (en) 2003-06-12
US7041666B2 (en) 2006-05-09
CA2468681A1 (en) 2003-06-12
AR038366A1 (es) 2005-01-12
EP1453835B1 (en) 2006-02-15
WO2003048164A3 (en) 2003-10-16
JP2005511698A (ja) 2005-04-28
DE60209251T2 (de) 2006-11-09
HK1064100A1 (en) 2005-01-21
TW200300686A (en) 2003-06-16
HUP0402270A2 (hu) 2005-02-28

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted