AU2002248597B2 - Automated methods of detecting receptor activity - Google Patents
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- AU2002248597B2 AU2002248597B2 AU2002248597A AU2002248597A AU2002248597B2 AU 2002248597 B2 AU2002248597 B2 AU 2002248597B2 AU 2002248597 A AU2002248597 A AU 2002248597A AU 2002248597 A AU2002248597 A AU 2002248597A AU 2002248597 B2 AU2002248597 B2 AU 2002248597B2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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- C—CHEMISTRY; METALLURGY
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- C12N2503/00—Use of cells in diagnostics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- Food Science & Technology (AREA)
- Wood Science & Technology (AREA)
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- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
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| US27533901P | 2001-03-13 | 2001-03-13 | |
| US60/275,339 | 2001-03-13 | ||
| US10/095,620 | 2002-03-12 | ||
| US10/095,620 US20030013137A1 (en) | 2001-03-13 | 2002-03-12 | Automated methods of detecting receptor activity |
| PCT/US2002/007434 WO2002073199A1 (en) | 2001-03-13 | 2002-03-13 | Automated methods of detecting receptor activity |
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| AU2002248597A1 AU2002248597A1 (en) | 2003-03-20 |
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| US (3) | US20030013137A1 (enExample) |
| EP (1) | EP1386154A4 (enExample) |
| JP (1) | JP2004532978A (enExample) |
| AU (1) | AU2002248597B2 (enExample) |
| CA (1) | CA2440683A1 (enExample) |
| WO (1) | WO2002073199A1 (enExample) |
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| EP1190249A2 (en) | 1999-06-08 | 2002-03-27 | University Of Iowa Research Foundation | Compounds and methods to enhance raav transduction |
| US7163800B2 (en) * | 2000-11-03 | 2007-01-16 | Molecular Devices Corporation | Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity |
| US20050136431A1 (en) * | 2000-11-03 | 2005-06-23 | Oakley Robert H. | Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity |
| US7144733B2 (en) * | 2001-08-16 | 2006-12-05 | Sloan-Kettering Institute For Cancer Research | Bio-synthetic photostimulators and methods of use |
| DE60325719D1 (de) * | 2002-05-13 | 2009-02-26 | Molecular Devices Corp | Konstitutiv translozierende zelllinie |
| FR2851379B1 (fr) * | 2003-02-18 | 2008-02-01 | Cit Alcatel | Convertisseur en transfert direct d'energie |
| DE60325640D1 (de) * | 2002-10-25 | 2009-02-12 | Mds Analytical Technologies Us | Verfahren zur identifizierung von transmembranrezeptoragonisten mit reduzierter internalisierung |
| US20050095225A1 (en) * | 2003-03-31 | 2005-05-05 | Engelhardt John F. | Compounds and methods for pharmico-gene therapy of epithelial sodium channel associated disorders |
| CN1894581B (zh) * | 2003-07-09 | 2012-02-01 | 生命技术公司 | 检测蛋白-蛋白相互作用的方法 |
| WO2006063216A2 (en) * | 2004-12-09 | 2006-06-15 | Cellomics, Inc | Automated method and system for setting image analysis parameters to control image analysis operations |
| JP2007006830A (ja) * | 2005-07-01 | 2007-01-18 | Olympus Corp | 細胞内の顆粒状構造物の測定方法 |
| AU2007243184A1 (en) * | 2006-04-28 | 2007-11-08 | University Of Iowa Research Foundation | Methods and compounds to modulate parvovirus transduction of mammalian cells or to alter virus infection, method to identify a viral receptor or co-receptor |
| CN101063657A (zh) * | 2006-04-29 | 2007-10-31 | 中国科学院上海生命科学研究院 | 在活体细胞中筛选配体与受体结合的方法和系统 |
| CN102460150B (zh) | 2009-04-20 | 2015-05-20 | 新加坡科技研究局 | 囊泡系统及其用途 |
| JP6058688B2 (ja) | 2011-11-23 | 2017-01-11 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 膜貫通輸送を監視するための組成物および方法 |
| US10809222B2 (en) * | 2013-04-25 | 2020-10-20 | The Trustees Of The University Of Pennsylvania | Opioid detection based on high quality graphene transistor arrays and a synthetic mu receptor |
| WO2017139381A1 (en) | 2016-02-08 | 2017-08-17 | University Of Iowa Research Foundation | Methods to produce chimeric adeno-associated virus/bocavirus parvovirus |
| MX2018010842A (es) | 2016-03-07 | 2019-07-04 | Univ Iowa Res Found | Expresion mediada por el virus adeno-asociado (aav) usando un promotor y pontenciador sintetico. |
| WO2017205739A1 (en) | 2016-05-26 | 2017-11-30 | University Of Iowa Research Foundation | cis AND trans REQUIREMENTS FOR TERMINAL RESOLUTION OF HUMAN BOCAVIRUS 1 |
| WO2018132747A1 (en) | 2017-01-13 | 2018-07-19 | University Of Iowa Research Foundation | Bocaparvovirus small noncoding rna and uses thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5891646A (en) * | 1997-06-05 | 1999-04-06 | Duke University | Methods of assaying receptor activity and constructs useful in such methods |
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| US4219335A (en) * | 1978-09-18 | 1980-08-26 | E. I. Du Pont De Nemours And Company | Immunochemical testing using tagged reagents |
| US4324633A (en) * | 1980-10-20 | 1982-04-13 | Lovejoy Curtis N | Electrolytic apparatus for treating continuous strip material |
| US5972629A (en) * | 1984-08-17 | 1999-10-26 | The Scripps Research Institute | Method for characterizing antigenic reactivity of biological sample |
| US4908773A (en) * | 1987-04-06 | 1990-03-13 | Genex Corporation | Computer designed stabilized proteins and method for producing same |
| US5744101A (en) * | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5548661A (en) * | 1991-07-12 | 1996-08-20 | Price; Jeffrey H. | Operator independent image cytometer |
| US5324633A (en) * | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| DE4138621A1 (de) * | 1991-11-25 | 1993-06-17 | Boehringer Ingelheim Int | Verfahren zum screenen von substanzen mit modulierender wirkung auf einen rezeptorabhaengigen zellulaeren signaluebertragungsweg |
| US5670113A (en) * | 1991-12-20 | 1997-09-23 | Sibia Neurosciences, Inc. | Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same |
| US5912122A (en) * | 1993-06-04 | 1999-06-15 | Sibia Neurosciences, Inc. | Nucleic acids encoding and method for detecting nucleic acid encoding human metabotropic glutamate receptor subtype mGluR6 |
| WO1995014791A1 (en) * | 1993-11-26 | 1995-06-01 | Hendry Lawrence B | Design of drugs involving receptor-ligand-dna interactions |
| GB9403600D0 (en) * | 1994-02-24 | 1994-04-13 | Univ Glasgow | Three dimensional hormone structure |
| US5521705A (en) * | 1994-05-12 | 1996-05-28 | Oldenbourg; Rudolf | Polarized light microscopy |
| US5463564A (en) * | 1994-09-16 | 1995-10-31 | 3-Dimensional Pharmaceuticals, Inc. | System and method of automatically generating chemical compounds with desired properties |
| AU693663B2 (en) * | 1995-03-17 | 1998-07-02 | Kureha Kagaku Kogyo Kabushiki Kaisha | Biochemical information processor, biochemical information processing method, and biochemical information recording medium |
| US6219622B1 (en) * | 1995-03-24 | 2001-04-17 | University Of Guelph | Computational method for designing chemical structures having common functional characteristics |
| US6017496A (en) * | 1995-06-07 | 2000-01-25 | Irori | Matrices with memories and uses thereof |
| US6025129A (en) * | 1995-04-25 | 2000-02-15 | Irori | Remotely programmable matrices with memories and uses thereof |
| US6100026A (en) * | 1995-04-25 | 2000-08-08 | Irori | Matrices with memories and uses thereof |
| US5545531A (en) * | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5770176A (en) * | 1995-12-08 | 1998-06-23 | Chiron Diagnostics Corporation | Assays for functional nuclear receptors |
| US6027890A (en) * | 1996-01-23 | 2000-02-22 | Rapigene, Inc. | Methods and compositions for enhancing sensitivity in the analysis of biological-based assays |
| JP3733392B2 (ja) * | 1996-03-05 | 2006-01-11 | イーストマン コダック カンパニー | 画像の構図変化検出方法 |
| US5989835A (en) * | 1997-02-27 | 1999-11-23 | Cellomics, Inc. | System for cell-based screening |
| US5804436A (en) * | 1996-08-02 | 1998-09-08 | Axiom Biotechnologies, Inc. | Apparatus and method for real-time measurement of cellular response |
| US5972639A (en) * | 1997-07-24 | 1999-10-26 | Irori | Fluorescence-based assays for measuring cell proliferation |
| US6221612B1 (en) * | 1997-08-01 | 2001-04-24 | Aurora Biosciences Corporation | Photon reducing agents for use in fluorescence assays |
| US5987390A (en) * | 1997-10-28 | 1999-11-16 | Smithkline Beecham Corporation | Methods and systems for identification of protein classes |
| WO2000003246A2 (en) * | 1998-07-13 | 2000-01-20 | Cellomics, Inc. | A system for cell-based screening |
| US6203987B1 (en) * | 1998-10-27 | 2001-03-20 | Rosetta Inpharmatics, Inc. | Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns |
| US6221600B1 (en) * | 1999-10-08 | 2001-04-24 | Board Of Regents, The University Of Texas System | Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5891646A (en) * | 1997-06-05 | 1999-04-06 | Duke University | Methods of assaying receptor activity and constructs useful in such methods |
| US6110693A (en) * | 1997-06-05 | 2000-08-29 | Duke University | Methods of assaying receptor activity and constructs useful in such methods |
Non-Patent Citations (1)
| Title |
|---|
| VRECL et.al.(1998) Molecular Endocrinology, 12:1818-1829 * |
Also Published As
| Publication number | Publication date |
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| JP2004532978A (ja) | 2004-10-28 |
| US20040029190A1 (en) | 2004-02-12 |
| US7455982B2 (en) | 2008-11-25 |
| WO2002073199A1 (en) | 2002-09-19 |
| EP1386154A4 (en) | 2004-09-15 |
| EP1386154A1 (en) | 2004-02-04 |
| US20030013137A1 (en) | 2003-01-16 |
| CA2440683A1 (en) | 2002-09-19 |
| US20050181423A1 (en) | 2005-08-18 |
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