AU2001291843A1 - Glutathione conjugates with distamycin derivatives having antitumoral activity - Google Patents

Glutathione conjugates with distamycin derivatives having antitumoral activity

Info

Publication number
AU2001291843A1
AU2001291843A1 AU2001291843A AU9184301A AU2001291843A1 AU 2001291843 A1 AU2001291843 A1 AU 2001291843A1 AU 2001291843 A AU2001291843 A AU 2001291843A AU 9184301 A AU9184301 A AU 9184301A AU 2001291843 A1 AU2001291843 A1 AU 2001291843A1
Authority
AU
Australia
Prior art keywords
antitumoral activity
distamycin derivatives
glutathione conjugates
glutathione
conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001291843A
Other languages
English (en)
Inventor
Italo Beria
Paolo Cozzi
Maria Cristina Geroni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Publication of AU2001291843A1 publication Critical patent/AU2001291843A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2001291843A 2000-09-15 2001-09-07 Glutathione conjugates with distamycin derivatives having antitumoral activity Abandoned AU2001291843A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2000MI002012A IT1318696B1 (it) 2000-09-15 2000-09-15 Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale.
ITMI200A002012 2000-09-15
PCT/EP2001/010397 WO2002022655A1 (en) 2000-09-15 2001-09-07 Glutathione conjugates with distamycin derivatives having antitumoral activity

Publications (1)

Publication Number Publication Date
AU2001291843A1 true AU2001291843A1 (en) 2002-03-26

Family

ID=11445804

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001291843A Abandoned AU2001291843A1 (en) 2000-09-15 2001-09-07 Glutathione conjugates with distamycin derivatives having antitumoral activity

Country Status (6)

Country Link
US (1) US6838547B2 (it)
EP (1) EP1330470A1 (it)
JP (1) JP2004509133A (it)
AU (1) AU2001291843A1 (it)
IT (1) IT1318696B1 (it)
WO (1) WO2002022655A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE435649T1 (de) * 2003-05-02 2009-07-15 Elan Pharm Inc 4-brom-5-(2-chlor-benzoylamino)-1h-pyrazol-3- carbonsäure(phenyl)amid-derivate und verwandte verbindungen als bradykinin b1 receptor antagonisten zur behandlung von entzündlichen erkrankungen
WO2004098589A1 (en) 2003-05-02 2004-11-18 Elan Pharmaceuticals, Inc. 4- bromo - 5 - (2- chloro - benzoylamino) - 1h - pyrazole - 3 - carboxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
JP2008506714A (ja) * 2004-07-16 2008-03-06 サネシス ファーマシューティカルズ， インコーポレイテッド オーロラキナーゼインヒビターとして有用なチエノピリミジン

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR950013762B1 (en) * 1986-10-07 1995-11-15 Boehringer Mannheim Italia Pharmaceutical compositions having antineoplastic activity
JP2926405B2 (ja) * 1988-02-20 1999-07-28 コニカ株式会社 高コントラストな画像を得ることができるハロゲン化銀写真感光材料
JP2919867B2 (ja) 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
EP0543576A1 (en) * 1991-11-21 1993-05-26 Konica Corporation A developer composition and a method for forming an image which uses the same
IT1272234B (it) * 1994-05-02 1997-06-16 Consiglio Nazionale Ricerche Derivati glutationici delle antracicline e procedimento per ottenerli.
US5880097A (en) * 1996-01-04 1999-03-09 Terrapin Techologies, Inc. Tethered prodrugs
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9806689D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9816652D0 (en) * 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB0011059D0 (en) * 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione

Also Published As

Publication number Publication date
WO2002022655A1 (en) 2002-03-21
ITMI20002012A1 (it) 2002-03-15
US6838547B2 (en) 2005-01-04
JP2004509133A (ja) 2004-03-25
IT1318696B1 (it) 2003-08-27
ITMI20002012A0 (it) 2000-09-15
EP1330470A1 (en) 2003-07-30
US20040038905A1 (en) 2004-02-26

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