US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US20040266706A1
(en)
*
|
2002-11-05 |
2004-12-30 |
Muthiah Manoharan |
Cross-linked oligomeric compounds and their use in gene modulation
|
WO2005121371A2
(en)
*
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US6559279B1
(en)
*
|
2000-09-08 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Process for preparing peptide derivatized oligomeric compounds
|
NO20004795D0
(en)
*
|
2000-09-26 |
2000-09-26 |
Nycomed Imaging As |
Peptide-based compounds
|
ATE544473T1
(en)
*
|
2000-11-09 |
2012-02-15 |
Cold Spring Harbor Lab |
CHIMERIC MOLECULES FOR MODULATION OF GENE EXPRESSION
|
US6878805B2
(en)
*
|
2002-08-16 |
2005-04-12 |
Isis Pharmaceuticals, Inc. |
Peptide-conjugated oligomeric compounds
|
WO2004044139A2
(en)
|
2002-11-05 |
2004-05-27 |
Isis Parmaceuticals, Inc. |
Modified oligonucleotides for use in rna interference
|
WO2004044141A2
(en)
*
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Conjugated oligomeric compounds and their use in gene modulation
|
US6913890B2
(en)
|
2002-12-18 |
2005-07-05 |
Palo Alto Research Center Incorporated |
Process for preparing albumin protein conjugated oligonucleotide probes
|
US20080015349A1
(en)
*
|
2003-01-24 |
2008-01-17 |
Third Wave Technologies, Inc. |
Oligonucleotide production
|
US7468418B2
(en)
|
2003-04-29 |
2008-12-23 |
Avi Biopharma., Inc. |
Compositions for enhancing transport of molecules into cells
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
US20050288246A1
(en)
|
2004-05-24 |
2005-12-29 |
Iversen Patrick L |
Peptide conjugated, inosine-substituted antisense oligomer compound and method
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
DE602005026386D1
(en)
|
2004-06-28 |
2011-03-31 |
Univ Western Australia |
ANTISENSE OLIGONUCLEOTIDES FOR THE INDUCTION OF EXON-SKIPPING AND METHOD OF USE THEREOF
|
USRE48960E1
(en)
|
2004-06-28 |
2022-03-08 |
The University Of Western Australia |
Antisense oligonucleotides for inducing exon skipping and methods of use thereof
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
EP1695717A1
(en)
*
|
2005-02-23 |
2006-08-30 |
Ludwig-Maximilians-Universität |
Transport of nano-and macromolecular structures into cytoplasm and nucleus of cells
|
US8067571B2
(en)
|
2005-07-13 |
2011-11-29 |
Avi Biopharma, Inc. |
Antibacterial antisense oligonucleotide and method
|
EP2023938A4
(en)
*
|
2006-05-23 |
2010-11-10 |
Isis Pharmaceuticals Inc |
Modulation of chrebp expression
|
US8198253B2
(en)
|
2006-07-19 |
2012-06-12 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to HBXIP
|
US20100016215A1
(en)
|
2007-06-29 |
2010-01-21 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
WO2009018490A1
(en)
*
|
2007-07-31 |
2009-02-05 |
Burnham Institute For Medical Research |
Bi-dentate compounds as kinase inhibitors
|
US20100280098A1
(en)
*
|
2007-10-05 |
2010-11-04 |
Juliano Rudolph L |
Receptor targeted oligonucleotides
|
US8575123B2
(en)
|
2008-04-11 |
2013-11-05 |
Tekmira Pharmaceuticals Corporation |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
US8815818B2
(en)
|
2008-07-18 |
2014-08-26 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell delivery of RNAI
|
EP2340309A2
(en)
|
2008-09-22 |
2011-07-06 |
Rxi Pharmaceuticals Corporation |
Neutral nanotransporters
|
EP2342616A2
(en)
|
2008-09-23 |
2011-07-13 |
Alnylam Pharmaceuticals Inc. |
Chemical modifications of monomers and oligonucleotides with cycloaddition
|
JP5864257B2
(en)
|
2008-10-24 |
2016-02-17 |
サレプタ セラピューティクス, インコーポレイテッド |
Multiple exon skipping compositions for DMD
|
KR20210158864A
(en)
|
2008-11-10 |
2021-12-31 |
알닐람 파마슈티칼스 인코포레이티드 |
Novel lipids and compositions for the delivery of therapeutics
|
JP5645840B2
(en)
|
2008-12-02 |
2014-12-24 |
株式会社Wave Life Sciences Japan |
Method for synthesizing phosphorous atom-modified nucleic acid
|
WO2010078536A1
(en)
|
2009-01-05 |
2010-07-08 |
Rxi Pharmaceuticals Corporation |
Inhibition of pcsk9 through rnai
|
US20100190691A1
(en)
*
|
2009-01-27 |
2010-07-29 |
Trojan Technologies, Ltd |
Delivery of nucleic acids using cell-penetrating peptides
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
AU2010221419B2
(en)
|
2009-03-02 |
2015-10-01 |
Alnylam Pharmaceuticals, Inc. |
Nucleic acid chemical modifications
|
PT3431076T
(en)
|
2009-06-10 |
2021-10-26 |
Arbutus Biopharma Corp |
Improved lipid formulation
|
MX342945B
(en)
|
2009-07-06 |
2016-10-18 |
Ontorii Inc * |
Novel nucleic acid prodrugs and methods use thereof.
|
KR102487132B1
(en)
|
2009-11-12 |
2023-01-10 |
더 유니버시티 오브 웨스턴 오스트레일리아 |
Antisense Molecules and Methods for Treating Pathologies
|
CA2783372C
(en)
|
2009-12-07 |
2019-07-16 |
Muthiah Manoharan |
Compositions for nucleic acid delivery
|
ES2749426T3
(en)
|
2009-12-18 |
2020-03-20 |
Univ British Columbia |
Nucleic Acid Administration Methods and Compositions
|
US9198972B2
(en)
|
2010-01-28 |
2015-12-01 |
Alnylam Pharmaceuticals, Inc. |
Monomers and oligonucleotides comprising cycloaddition adduct(s)
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
WO2011119852A1
(en)
|
2010-03-24 |
2011-09-29 |
Rxi Pharmaceuticals Corporation |
Reduced size self-delivering rnai compounds
|
AU2011230537C1
(en)
|
2010-03-26 |
2018-08-02 |
Trustees Of Dartmouth College |
Vista regulatory T cell mediator protein, vista binding agents and use thereof
|
US20150231215A1
(en)
|
2012-06-22 |
2015-08-20 |
Randolph J. Noelle |
VISTA Antagonist and Methods of Use
|
US10745467B2
(en)
|
2010-03-26 |
2020-08-18 |
The Trustees Of Dartmouth College |
VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
|
US9102938B2
(en)
|
2010-04-01 |
2015-08-11 |
Alnylam Pharmaceuticals, Inc. |
2′ and 5′ modified monomers and oligonucleotides
|
US20130260460A1
(en)
|
2010-04-22 |
2013-10-03 |
Isis Pharmaceuticals Inc |
Conformationally restricted dinucleotide monomers and oligonucleotides
|
US10913767B2
(en)
|
2010-04-22 |
2021-02-09 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
US9725479B2
(en)
|
2010-04-22 |
2017-08-08 |
Ionis Pharmaceuticals, Inc. |
5′-end derivatives
|
WO2011163121A1
(en)
|
2010-06-21 |
2011-12-29 |
Alnylam Pharmaceuticals, Inc. |
Multifunctional copolymers for nucleic acid delivery
|
WO2011163401A2
(en)
|
2010-06-22 |
2011-12-29 |
Neogenix Oncology, Inc. |
Colon and pancreas cancer specific antigens and antibodies
|
US20130323269A1
(en)
|
2010-07-30 |
2013-12-05 |
Muthiah Manoharan |
Methods and compositions for delivery of active agents
|
WO2012016188A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
US9068014B2
(en)
|
2010-09-23 |
2015-06-30 |
Precision Biologics, Inc. |
Colon and pancreas cancer peptidomimetics
|
WO2012039448A1
(en)
|
2010-09-24 |
2012-03-29 |
株式会社キラルジェン |
Asymmetric auxiliary group
|
SG10201508118WA
(en)
|
2010-09-30 |
2015-11-27 |
Agency Science Tech & Res |
Methods and reagents for detection and treatment of esophageal metaplasia
|
WO2012071561A2
(en)
|
2010-11-23 |
2012-05-31 |
Alder Biopharmaceuticals, Inc. |
Anti-il-6 antibodies for the treatment of anemia
|
DK2663548T3
(en)
|
2011-01-11 |
2017-07-24 |
Alnylam Pharmaceuticals Inc |
PEGYLED LIPIDS AND THEIR USE FOR PHARMACEUTICAL SUPPLY
|
US9161948B2
(en)
|
2011-05-05 |
2015-10-20 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
AU2012260601B2
(en)
|
2011-05-25 |
2018-02-01 |
Innate Pharma, S.A. |
Anti-KIR antibodies for the treatment of inflammatory disorders
|
DK2734208T3
(en)
|
2011-07-19 |
2017-06-19 |
Wave Life Sciences Ltd |
PROCEDURES FOR SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS
|
AU2012315965A1
(en)
|
2011-09-27 |
2014-04-03 |
Alnylam Pharmaceuticals, Inc. |
Di-aliphatic substituted PEGylated lipids
|
BR112014032276A2
(en)
|
2012-06-22 |
2017-11-28 |
King S College London |
vista-ig constructs and the use of vista-ig for the treatment of autoimmune, allergic and inflammatory disorders
|
US9890215B2
(en)
|
2012-06-22 |
2018-02-13 |
King's College London |
Vista modulators for diagnosis and treatment of cancer
|
CN104684923B
(en)
|
2012-07-13 |
2018-09-28 |
株式会社新日本科学 |
Chiral Nuclec acid adjuvants
|
DK2872147T3
(en)
|
2012-07-13 |
2023-02-20 |
Wave Life Sciences Ltd |
METHOD FOR PREPARATION OF CHIRAL OLIGONUCLEOTIDES
|
ES2862073T3
(en)
|
2012-07-13 |
2021-10-06 |
Wave Life Sciences Ltd |
Asymmetric auxiliary group
|
AU2013312211B2
(en)
|
2012-09-07 |
2018-03-29 |
King's College London |
VISTA modulators for diagnosis and treatment of cancer
|
US10077443B2
(en)
|
2012-11-15 |
2018-09-18 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide conjugates
|
US9938344B2
(en)
|
2012-12-28 |
2018-04-10 |
Precision Biologics, Inc. |
Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer
|
CN110218727A
(en)
|
2013-03-14 |
2019-09-10 |
萨勒普塔医疗公司 |
For treating the exon skipping composition of muscular dystrophy
|
BR112015022998A2
(en)
|
2013-03-15 |
2017-11-14 |
Sarepta Therapeutics Inc |
improved compositions for treating muscular dystrophy
|
EP2978446B1
(en)
|
2013-03-27 |
2020-03-04 |
The General Hospital Corporation |
Anti-cd33 antibody for use in treating alzheimer's disease
|
DK3087098T3
(en)
|
2013-12-24 |
2020-06-08 |
Janssen Pharmaceutica Nv |
Anti-Vista antibodies and fragments
|
US11014987B2
(en)
|
2013-12-24 |
2021-05-25 |
Janssen Pharmaceutics Nv |
Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
|
US10144933B2
(en)
|
2014-01-15 |
2018-12-04 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
|
US10322173B2
(en)
|
2014-01-15 |
2019-06-18 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
|
WO2015108048A1
(en)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
|
AU2015207773B2
(en)
|
2014-01-16 |
2021-06-17 |
Wave Life Sciences Ltd. |
Chiral design
|
HRP20220379T1
(en)
|
2014-06-10 |
2022-05-27 |
Erasmus University Medical Center Rotterdam |
Antisense oligonucleotides useful in treatment of pompe disease
|
WO2015191881A2
(en)
|
2014-06-11 |
2015-12-17 |
Green Kathy A |
Use of vista agonists and antagonists to suppress or enhance humoral immunity
|
WO2016090347A1
(en)
|
2014-12-05 |
2016-06-09 |
Immunext, Inc. |
Identification of vsig8 as the putative vista receptor and its use thereof to produce vista/vsig8 modulators
|
EP3234141A4
(en)
|
2014-12-18 |
2018-06-20 |
Alnylam Pharmaceuticals, Inc. |
Reversir tm compounds
|
US10675356B2
(en)
*
|
2015-05-19 |
2020-06-09 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
WO2016196897A1
(en)
|
2015-06-04 |
2016-12-08 |
Sarepta Therapeutics, Inc. |
Methods and compounds for treatment of lymphocyte-related diseases and conditions
|
CN107922497B
(en)
|
2015-06-24 |
2022-04-12 |
詹森药业有限公司 |
anti-VISTA antibodies and fragments
|
CA2989970A1
(en)
|
2015-07-17 |
2017-01-26 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
US10993995B2
(en)
|
2015-12-07 |
2021-05-04 |
Erasmus University Medical Center Rotterdam |
Enzymatic replacement therapy and antisense therapy for pompe disease
|
CN109069626A
(en)
|
2016-02-12 |
2018-12-21 |
詹森药业有限公司 |
Anti- VISTA (B7H5) antibody
|
WO2017181139A2
(en)
|
2016-04-15 |
2017-10-19 |
Michael Molloy |
Anti-human vista antibodies and use thereof
|
EA039716B1
(en)
*
|
2016-05-17 |
2022-03-03 |
Сарепта Терапьютикс, Инк. |
Peptide-oligonucleotide conjugates
|
NL2017294B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Natural cryptic exon removal by pairs of antisense oligonucleotides.
|
NL2017295B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Antisense oligomeric compound for Pompe disease
|
RS63610B1
(en)
|
2016-12-19 |
2022-10-31 |
Sarepta Therapeutics Inc |
Exon skipping oligomer conjugates for muscular dystrophy
|
WO2019006455A1
(en)
|
2017-06-30 |
2019-01-03 |
Solstice Biologics, Ltd. |
Chiral phosphoramidite auxiliaries and methods of their use
|
KR20210018267A
(en)
|
2018-05-07 |
2021-02-17 |
알닐람 파마슈티칼스 인코포레이티드 |
Extrahepatic delivery
|
EP3856907A1
(en)
|
2018-09-28 |
2021-08-04 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
CA3138915A1
(en)
|
2019-05-17 |
2020-11-26 |
Alnylam Pharmaceuticals, Inc. |
Oral delivery of oligonucleotides
|
AU2020378414A1
(en)
|
2019-11-06 |
2022-05-26 |
Alnylam Pharmaceuticals, Inc. |
Extrahepatic delivery
|
WO2021092145A1
(en)
|
2019-11-06 |
2021-05-14 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna composition and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
KR102397922B1
(en)
*
|
2020-02-19 |
2022-05-13 |
서울대학교 산학협력단 |
Novel tumor-associated antigen protein OLFM4 and the use thereof
|
US20230257745A1
(en)
|
2020-07-10 |
2023-08-17 |
Alnylam Pharmaceuticals, Inc. |
Circular siRNAs
|
AU2021411579A1
(en)
|
2020-12-31 |
2023-07-13 |
Alnylam Pharmaceuticals, Inc. |
Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
|
WO2022147223A2
(en)
|
2020-12-31 |
2022-07-07 |
Alnylam Pharmaceuticals, Inc. |
2'-modified nucleoside based oligonucleotide prodrugs
|
WO2023283403A2
(en)
|
2021-07-09 |
2023-01-12 |
Alnylam Pharmaceuticals, Inc. |
Bis-rnai compounds for cns delivery
|
KR20240036041A
(en)
|
2021-07-21 |
2024-03-19 |
알닐람 파마슈티칼스 인코포레이티드 |
Metabolic Disorder-Associated Target Gene iRNA Composition and Methods of Using Same
|
AU2022364838A1
(en)
|
2021-10-15 |
2024-04-11 |
Alnylam Pharmaceuticals, Inc. |
Extra-hepatic delivery irna compositions and methods of use thereof
|
CN114644684B
(en)
*
|
2022-02-14 |
2023-06-27 |
浙江大学杭州国际科创中心 |
Cell membrane penetrating peptide and application thereof
|
WO2023220744A2
(en)
|
2022-05-13 |
2023-11-16 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded loop oligonucleotides
|
WO2024006999A2
(en)
|
2022-06-30 |
2024-01-04 |
Alnylam Pharmaceuticals, Inc. |
Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
|
WO2024073732A1
(en)
|
2022-09-30 |
2024-04-04 |
Alnylam Pharmaceuticals, Inc. |
Modified double-stranded rna agents
|