AU2001273453A1 - Nucleic acid hairpin probes and uses thereof - Google Patents

Nucleic acid hairpin probes and uses thereof

Info

Publication number
AU2001273453A1
AU2001273453A1 AU2001273453A AU7345301A AU2001273453A1 AU 2001273453 A1 AU2001273453 A1 AU 2001273453A1 AU 2001273453 A AU2001273453 A AU 2001273453A AU 7345301 A AU7345301 A AU 7345301A AU 2001273453 A1 AU2001273453 A1 AU 2001273453A1
Authority
AU
Australia
Prior art keywords
nucleic acid
hairpin probes
acid hairpin
probes
nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001273453A
Inventor
Nanibhushan Dattagupta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Gene Technologies Inc
Original Assignee
Applied Gene Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/616,761 external-priority patent/US6380377B1/en
Application filed by Applied Gene Technologies Inc filed Critical Applied Gene Technologies Inc
Publication of AU2001273453A1 publication Critical patent/AU2001273453A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
AU2001273453A 2000-07-14 2001-07-12 Nucleic acid hairpin probes and uses thereof Abandoned AU2001273453A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/616,761 2000-07-14
US09/616,761 US6380377B1 (en) 2000-07-14 2000-07-14 Nucleic acid hairpin probes and uses thereof
US09/823,647 US6596490B2 (en) 2000-07-14 2001-03-30 Nucleic acid hairpin probes and uses thereof
US09/823,647 2001-03-30
PCT/US2001/022166 WO2002006531A2 (en) 2000-07-14 2001-07-12 Nucleic acid hairpin probes and uses thereof

Publications (1)

Publication Number Publication Date
AU2001273453A1 true AU2001273453A1 (en) 2002-01-30

Family

ID=27087855

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001273453A Abandoned AU2001273453A1 (en) 2000-07-14 2001-07-12 Nucleic acid hairpin probes and uses thereof

Country Status (3)

Country Link
US (2) US6596490B2 (en)
AU (1) AU2001273453A1 (en)
WO (1) WO2002006531A2 (en)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7354390B1 (en) * 1996-09-30 2008-04-08 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Seed coat specific nucleotide sequence encoding peroxidase
US6825337B2 (en) * 2002-05-31 2004-11-30 Isis Pharmaceuticals, Inc. Antisense modulation of PLML expression
US20010039014A1 (en) * 2000-01-11 2001-11-08 Maxygen, Inc. Integrated systems and methods for diversity generation and screening
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
US6858413B2 (en) 2000-12-13 2005-02-22 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
EP1390537B1 (en) * 2001-03-09 2013-11-13 Nugen Technologies, Inc. Methods and compositions for amplification of rna sequences
BR0205268A (en) 2001-03-09 2004-11-30 Nugen Technologies Inc Processes and compositions for mRNA sequence mplification
JP2003043037A (en) * 2001-07-27 2003-02-13 Inst Of Physical & Chemical Res Substrate for hybridization, manufacturing method and usage method of the substrate
US7094537B2 (en) * 2002-04-30 2006-08-22 Agilent Technologies, Inc. Micro arrays with structured and unstructured probes
US20040058886A1 (en) * 2002-08-08 2004-03-25 Dharmacon, Inc. Short interfering RNAs having a hairpin structure containing a non-nucleotide loop
WO2004050916A1 (en) * 2002-12-02 2004-06-17 Solexa Limited Recovery of original template
ATE462017T1 (en) * 2002-12-02 2010-04-15 Illumina Cambridge Ltd DETERMINATION OF METHYLATION OF NUCLEIC ACID SEQUENCES
EP3000899A1 (en) 2002-12-04 2016-03-30 Applied Biosystems, LLC Multiplex amplification of polynucleotides
FR2852317B1 (en) * 2003-03-13 2006-08-04 PROBE BIOPUCES AND METHODS OF USE
CA2521084A1 (en) 2003-04-14 2004-10-28 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
EP1660679B1 (en) * 2003-08-01 2012-11-14 Dynal Biotech Inc. Self-hybridizing multiple target nucleic acid probes and methods of use
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
CA2542768A1 (en) * 2003-10-28 2005-05-12 Epoch Biosciences, Inc. Fluorescent probes for dna detection by hybridization with improved sensitivity and low background
WO2005077125A2 (en) * 2004-02-11 2005-08-25 Applera Corporation Methods and compositions for detecting nucleic acids
EP1721011A1 (en) 2004-03-01 2006-11-15 Applera Corporation Methods, compositions and kits for use in polynucleotide amplification
US7593483B2 (en) * 2004-05-07 2009-09-22 Broadcom Corporation Nonlinear mapping in digital-to-analog and analog-to-digital converters
EP2290071B1 (en) 2004-05-28 2014-12-31 Asuragen, Inc. Methods and compositions involving microRNA
DE602005020943D1 (en) 2004-07-01 2010-06-10 Gen Probe Inc METHOD AND COMPOSITIONS FOR DETECTING NUCLEIC ACIDS IN A BIOLOGICAL SAMPLE
KR100663992B1 (en) 2004-07-05 2007-01-02 (주)바이오메드랩 The method selecting highly specific probes for HPV genotype analysis and the probes thereof
EP1791982B1 (en) 2004-09-21 2011-01-05 Life Technologies Corporation TWO-COLOR REAL-TIME/END-POINT QUANTITATION OF MICRORNAS (MIRNAs)
DK2302055T3 (en) 2004-11-12 2014-10-13 Asuragen Inc Methods and compositions involving miRNA and miRNA inhibitor molecules
EP1841879A4 (en) * 2005-01-25 2009-05-27 Population Genetics Technologi Isothermal dna amplification
WO2007030759A2 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
WO2007087262A2 (en) * 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Selective genome amplification
AU2007281535A1 (en) 2006-08-01 2008-02-07 Applied Biosystems, Llc. Detection of analytes and nucleic acids
US20080131878A1 (en) * 2006-12-05 2008-06-05 Asuragen, Inc. Compositions and Methods for the Detection of Small RNA
EP2104734A2 (en) * 2006-12-08 2009-09-30 Asuragen, INC. Mir-20 regulated genes and pathways as targets for therapeutic intervention
WO2008096146A1 (en) 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
WO2009035554A2 (en) * 2007-09-07 2009-03-19 University Of Florida Research Foundation, Inc. Superior structure stability and selectivity of hairpin nucleic acid probes with an l-dna stem
WO2009036332A1 (en) 2007-09-14 2009-03-19 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
CA2705852C (en) * 2007-11-21 2018-06-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Photoinduced electron transfer (pet) primer for nucleic acid amplification
WO2009070805A2 (en) 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
US20090203531A1 (en) 2008-02-12 2009-08-13 Nurith Kurn Method for Archiving and Clonal Expansion
WO2009117698A2 (en) 2008-03-21 2009-09-24 Nugen Technologies, Inc. Methods of rna amplification in the presence of dna
WO2009126726A1 (en) * 2008-04-08 2009-10-15 Asuragen, Inc Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
EP2644709B1 (en) 2008-04-30 2014-12-17 Integrated Dna Technologies, Inc. RNase-H-based assays utilizing modified RNA monomers
US9434988B2 (en) 2008-04-30 2016-09-06 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
EP2806037B1 (en) 2008-05-13 2016-09-21 Gen-Probe Incorporated Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
EP2367958B1 (en) 2008-11-25 2017-08-23 Gen-Probe Incorporated Compositions and methods for detecting small rnas, and uses thereof
JP2012511927A (en) 2008-12-17 2012-05-31 ライフ テクノロジーズ コーポレーション Methods, compositions, and kits for detecting allelic variants
EP3249053A1 (en) 2009-03-27 2017-11-29 Life Technologies Corporation Methods, compositions, and kits for detecting allelic variants
CA2762986C (en) 2009-05-22 2018-03-06 Asuragen, Inc. Mirna biomarkers of prostate disease
WO2011017567A1 (en) 2009-08-05 2011-02-10 Life Technologies Corporation Methods for the analysis of proximity binding assay data
EP2470897A4 (en) 2009-08-28 2013-05-29 Asuragen Inc Mirna biomarkers of lung disease
WO2011130184A2 (en) 2010-04-11 2011-10-20 Life Technologies Corporation SYSTEMS AND METHODS FOR MODEL-BASED qPCR
DK2582839T3 (en) 2010-06-21 2016-08-29 Life Technologies Corp Compositions, methods and kits for nucleic acid synthesis and amplification by RT
EP2582850B1 (en) 2010-06-21 2016-11-09 Life Technologies Corporation Compositions, kits, and methods for synthesis and/or detection of nucleic acids
EP2641201B1 (en) 2010-11-16 2018-12-26 Life Technologies Corporation Systems and methods for the analysis of proximity binding assay data
EP2658998B1 (en) 2010-12-29 2015-04-22 Life Technologies Corporation Ddao compounds as fluorescent reference standards
EP3567121B1 (en) 2011-01-17 2023-08-30 Life Technologies Corporation Workflow for detection of ligands using nucleic acids
US20140170653A1 (en) 2011-04-15 2014-06-19 Life Technologies Corporation Chemical ligation
EP4249603A3 (en) 2011-06-08 2024-01-03 Life Technologies Corporation Design and development of novel detergents for use in pcr systems
WO2012170907A2 (en) 2011-06-08 2012-12-13 Life Technologies Corporation Polymerization of nucleic acids using proteins having low isoelectric points
RU2639509C2 (en) 2011-06-27 2017-12-21 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Micro-rna-biomarkers indicating alzheimer's disease
AU2012296385A1 (en) 2011-08-18 2014-02-20 Nestec S.A. Compositions and methods for detecting allelic variants
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
US20130179086A1 (en) 2011-11-29 2013-07-11 Life Technologies Corporation Systems and methods for the determination of a copy number of a genomic sequence
CN102643910B (en) * 2012-04-10 2014-10-15 中国人民解放军第三军医大学第一附属医院 Application of asymmetric multicolor fluorescence hairpin probe chain reaction in pathogenic bacterium detection
WO2013153911A1 (en) * 2012-04-12 2013-10-17 国立大学法人東京大学 Nucleic acid quantification method, detection probe, detection probe set, and nucleic acid detection method
WO2013188839A1 (en) 2012-06-14 2013-12-19 Life Technologies Corporation Novel compositions, methods and kits for real time polymerase chain reaction (pcr)
GB201217770D0 (en) 2012-10-04 2012-11-14 Base4 Innovation Ltd Biological probes and the use thereof
EP3260558B1 (en) 2012-11-02 2020-05-13 Life Technologies Corporation Novel compositions and methods for enhancing pcr specificity
EP3640347A3 (en) 2013-03-12 2020-07-29 Life Technologies Corporation Universal reporter-based genotyping methods and materials
CN105102635B (en) 2013-03-15 2020-09-25 生命技术公司 Classification and feasibility index of Lung cancer
US9777333B2 (en) 2013-04-05 2017-10-03 Life Technologies Corporation Gene fusion
EP3044324A1 (en) 2013-09-13 2016-07-20 Life Technologies Corporation Classification and actionability indices for cancer
CN106458885B (en) 2013-10-25 2019-12-10 生命技术公司 Novel compounds for use in polymerase chain reaction systems and uses thereof
US20150191794A1 (en) 2014-01-05 2015-07-09 Biomirna Holdings Ltd. Lung Cancer Determinations Using MIRNA
WO2015120382A1 (en) 2014-02-07 2015-08-13 The Johns Hopkins University Predicting response to epigenetic drug therapy
CN106414768B (en) 2014-03-27 2020-05-29 生命技术公司 Gene fusions and gene variants associated with cancer
JP6940404B2 (en) 2014-08-19 2021-09-29 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Methods and compositions for nucleic acid detection
WO2016065192A1 (en) 2014-10-22 2016-04-28 Roka Bioscience, Inc. Compositions and methods for the detection of nucleic acids
WO2016094330A2 (en) 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
WO2016092045A1 (en) 2014-12-11 2016-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for predicting medically refractory acute severe colitis
WO2016177774A1 (en) 2015-05-04 2016-11-10 Academisch Medisch Centrum Method of quantifying mirnas using normalization
CN107771222B (en) * 2015-05-07 2019-06-04 巴黎科学与文学联大-拉丁区 Hair clip is formed in situ in the chain intrusion induced using power
AU2017248219B2 (en) 2016-04-06 2023-09-07 Life Technologies Corporation Compositions, methods, and kits for synthesis and detection of nucleic acids
US20190127783A1 (en) * 2016-04-27 2019-05-02 Prominex, Inc. Compositions and methods for the detection of nucleic acids
EP3472349A1 (en) 2016-06-16 2019-04-24 Life Technologies Corporation Novel compositions, methods and kits for microorganism detection
AU2017295717B2 (en) 2016-07-15 2021-06-24 The Regents Of The University Of California Methods of producing nucleic acid libraries
CN109689886A (en) 2016-08-26 2019-04-26 生命技术公司 Nucleic acid extraction and amplification control and its application method
WO2018045162A1 (en) 2016-09-01 2018-03-08 Biogen Ma Inc. Biomarkers predictive of primary progressive multiple sclerosis and uses thereof
US20200340041A1 (en) 2017-11-13 2020-10-29 Life Technologies Corporation Novel compositions, methods and kits for urinary tract microorganism detection
JP7296969B2 (en) 2018-01-12 2023-06-23 クラレット バイオサイエンス， エルエルシー Methods and compositions for analyzing nucleic acids
AU2019280712A1 (en) 2018-06-06 2021-01-07 The Regents Of The University Of California Methods of producing nucleic acid libraries and compositions and kits for practicing same
WO2020047081A1 (en) 2018-08-30 2020-03-05 Life Technologies Corporation Machine learning system for genotyping pcr assays
JP7254165B2 (en) 2018-08-31 2023-04-07 ライフ テクノロジーズ コーポレーション Image-Driven Quality Control for Array-Based PCR
EP3719144A1 (en) 2019-04-05 2020-10-07 Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) Mir-151a-3p as an universal endogenous control for exosome cargo normalization
EP3999664A1 (en) 2019-07-19 2022-05-25 Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) Method for determining the response to treatment of a patient affected by non-small cell lung carcinoma (nsclc)
DE102020103966B4 (en) 2020-02-14 2022-03-03 Testo bioAnalytics GmbH Probe complex for the specific detection of at least one substance, corresponding method and use
DE102020103958B4 (en) 2020-02-14 2021-08-26 Testo bioAnalytics GmbH Oligonucleotide probe for the specific detection of microorganisms, corresponding method and use
KR20230056685A (en) 2020-07-23 2023-04-27 라이프 테크놀로지스 코포레이션 Compositions, systems and methods for biological assays using dyes
US20240060117A1 (en) 2020-07-23 2024-02-22 Life Technologies Corporation Energy transfer dye conjugates for use in biological assays
WO2022178216A2 (en) 2021-02-22 2022-08-25 Cotropia Joseph Corona virus antigens and epitopes and proteins that bind thereto
WO2022197882A1 (en) 2021-03-18 2022-09-22 Cotropia Joseph Human immunodeficiency virus (hiv) antigens and epitopes and proteins that bind thereto
WO2023004356A2 (en) 2021-07-21 2023-01-26 Life Technologies Corporation Azaindole cyanine dyes, uses, and methods of preparation
CN117897454A (en) 2021-07-21 2024-04-16 生命技术公司 Dibenzoxanthene quencher, use and preparation method
US20230242652A1 (en) 2021-08-30 2023-08-03 Galderma Holding S.A. Treatments for atopic dermatitis
WO2023039525A1 (en) 2021-09-10 2023-03-16 Life Technologies Corporation Master mix compositions, kits, and methods
WO2023081221A1 (en) 2021-11-02 2023-05-11 Life Technologies Corporation Compositions and methods for reducing master mix contamination
CN114410749B (en) * 2022-01-25 2023-10-24 河南中医药大学 Electrochemiluminescence detection kit and method based on click chemistry and ARGET-ATRP amplification strategy

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN142734B (en) 1975-04-28 1977-08-20 Miles Lab
US4230797A (en) 1975-04-28 1980-10-28 Miles Laboratories, Inc. Heterogenous specific binding assay employing a coenzyme as label
US4134792A (en) 1976-12-06 1979-01-16 Miles Laboratories, Inc. Specific binding assay with an enzyme modulator as a labeling substance
US4238565A (en) 1978-06-22 1980-12-09 Miles Laboratories, Inc. Specific binding assay with a prosthetic group as a label component
US4948882A (en) 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
US5348855A (en) 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
DE3803275A1 (en) 1988-02-04 1989-08-17 Dornier Medizintechnik PIEZOELECTRIC SHOCK WAVE SOURCE
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
DE3924454A1 (en) 1989-07-24 1991-02-07 Cornelis P Prof Dr Hollenberg THE APPLICATION OF DNA AND DNA TECHNOLOGY FOR THE CONSTRUCTION OF NETWORKS FOR USE IN CHIP CONSTRUCTION AND CHIP PRODUCTION (DNA CHIPS)
US5149797A (en) 1990-02-15 1992-09-22 The Worcester Foundation For Experimental Biology Method of site-specific alteration of rna and production of encoded polypeptides
GB9027211D0 (en) 1990-12-14 1991-02-06 Smithkline Beecham Plc Medicaments
US5587472A (en) 1991-08-13 1996-12-24 Bayer Corporation Coumarin-labeled nucleoside 5'-triphosphates
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
DE69233331T3 (en) 1991-11-22 2007-08-30 Affymetrix, Inc., Santa Clara Combinatorial Polymersynthesis Strategies
US5312233A (en) 1992-02-25 1994-05-17 Ivek Corporation Linear liquid dispensing pump for dispensing liquid in nanoliter volumes
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
JPH0622798A (en) 1992-07-07 1994-02-01 Hitachi Ltd Method for determining base sequence
DE4222254A1 (en) 1992-07-07 1994-01-13 Bayer Ag Photochemical labeling of nucleic acids with digoxigenin reagents and their use in gene probe test systems
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
EP0601889A2 (en) 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nucleic acid probes
US5861242A (en) 1993-06-25 1999-01-19 Affymetrix, Inc. Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5932450A (en) 1995-06-07 1999-08-03 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using digestible templates
WO1997039150A1 (en) 1996-04-15 1997-10-23 University Of Southern California Synthesis of fluorophore-labeled dna
US5866336A (en) 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
JP3891620B2 (en) 1996-11-14 2007-03-14 株式会社アイシン・コスモス研究所 Nucleic acid probe molecule having a hairpin structure, and nucleic acid detection method using the nucleic acid probe molecule
DE19716073A1 (en) 1997-04-17 1998-10-22 Boehringer Mannheim Gmbh Dosing device for dispensing small amounts of liquid
AU1366299A (en) 1997-10-27 1999-05-17 Boston Probes, Inc. Methods, kits and compositions pertaining to pna molecular beacons
WO2000017346A2 (en) 1998-09-21 2000-03-30 Ribozyme Pharmaceuticals, Inc. Hairpin hybridizer molecules for modulation of gene expression
US6277607B1 (en) 1999-05-24 2001-08-21 Sanjay Tyagi High specificity primers, amplification methods and kits

Also Published As

Publication number Publication date
US20020142309A1 (en) 2002-10-03
US20030165963A1 (en) 2003-09-04
US6596490B2 (en) 2003-07-22
WO2002006531A2 (en) 2002-01-24
WO2002006531A3 (en) 2003-07-10

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