AU2001272327A1 - Method and device for detecting substances in body fluids by raman spectroscopy - Google Patents

Method and device for detecting substances in body fluids by raman spectroscopy

Info

Publication number
AU2001272327A1
AU2001272327A1 AU2001272327A AU7232701A AU2001272327A1 AU 2001272327 A1 AU2001272327 A1 AU 2001272327A1 AU 2001272327 A AU2001272327 A AU 2001272327A AU 7232701 A AU7232701 A AU 7232701A AU 2001272327 A1 AU2001272327 A1 AU 2001272327A1
Authority
AU
Australia
Prior art keywords
raman spectroscopy
body fluids
substances
detection
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001272327A
Inventor
Klaus Muller-Dethlefs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MULLER DETHLEFS KLAUS
Original Assignee
MULLER DETHLEFS KLAUS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MULLER DETHLEFS KLAUS filed Critical MULLER DETHLEFS KLAUS
Publication of AU2001272327A1 publication Critical patent/AU2001272327A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering

Abstract

The invention relates to a method and to a device for the non-invasive detection or determination, by Raman spectroscopy, of the concentration of substances in body fluids. The aim of the invention is to facilitate a non-invasive in vivo detection of substances in body fluids that allows for very accurate, reproducible results of analysis while requiring only little time for measuring which is acceptable for the patient. To this end, the inventive method and device for carrying out a Raman spectroscopy of a body fluid in a body tissue (1) records at least two Raman spectrums under different physical conditions and compares them with each other. The result of comparison allows detection of the substance one is looking for and measurement of the concentration of said substance.
AU2001272327A 2000-05-31 2001-05-31 Method and device for detecting substances in body fluids by raman spectroscopy Abandoned AU2001272327A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10027100 2000-05-31
DE10027100A DE10027100C2 (en) 2000-05-31 2000-05-31 Method and device for detecting substances in body fluids
PCT/DE2001/002068 WO2001091632A1 (en) 2000-05-31 2001-05-31 Method and device for detecting substances in body fluids by raman spectroscopy

Publications (1)

Publication Number Publication Date
AU2001272327A1 true AU2001272327A1 (en) 2001-12-11

Family

ID=7644294

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001272327A Abandoned AU2001272327A1 (en) 2000-05-31 2001-05-31 Method and device for detecting substances in body fluids by raman spectroscopy

Country Status (8)

Country Link
US (1) US6868285B2 (en)
EP (1) EP1292220B1 (en)
JP (1) JP3715241B2 (en)
AT (1) ATE347852T1 (en)
AU (1) AU2001272327A1 (en)
DE (2) DE10027100C2 (en)
HK (1) HK1055552B (en)
WO (1) WO2001091632A1 (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1329716A1 (en) * 2002-01-16 2003-07-23 Roche Diagnostics GmbH Method for screening biological samples for presence of the metabolic syndrome
WO2003079900A1 (en) * 2002-03-25 2003-10-02 Ken-Ichi Yamakoshi Noninvasive blood component value measuring instrument and method
US7259906B1 (en) 2002-09-03 2007-08-21 Cheetah Omni, Llc System and method for voice control of medical devices
FR2850998B1 (en) * 2003-02-06 2008-06-13 Piscines Desjoyaux Sa DEVICE FOR CONNECTING PIPES
DE10311452B4 (en) * 2003-03-15 2006-04-13 Roche Diagnostics Gmbh Analysis system for the reagent-free determination of the concentration of an analyte in living tissue
US20060234386A1 (en) * 2003-04-30 2006-10-19 Mcgill University Method and system for measuring lactate levels in vivo
US7266401B2 (en) * 2003-08-22 2007-09-04 C8 Medisensors Inc. Measuring analytes from an electromagnetic spectrum using a wavelength router
WO2006003551A1 (en) * 2004-07-02 2006-01-12 Koninklijke Philips Electronics N.V. Spectroscopic system with multiple probes
SE0402292D0 (en) * 2004-09-23 2004-09-23 Goeran Palmskog Arrangement for determining concentration of a substance in a fluid
GB0426993D0 (en) * 2004-12-09 2005-01-12 Council Cent Lab Res Councils Apparatus for depth-selective raman spectroscopy
JP2008524577A (en) * 2004-12-15 2008-07-10 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Method and apparatus for calibration of optical analytical markings using multivariate optical elements
JP4611788B2 (en) * 2005-04-12 2011-01-12 サンテック株式会社 Optical deflection probe and optical deflection probe apparatus
WO2006116637A2 (en) * 2005-04-27 2006-11-02 Massachusetts Institute Of Technology Raman spectroscopy for non-invasive glucose measurements
DE102005024511B4 (en) * 2005-05-26 2007-07-26 Hermsdorfer Institut Für Technische Keramik E.V. Measuring device for Raman spectrometric, non-invasive glucose determination
US7330746B2 (en) 2005-06-07 2008-02-12 Chem Image Corporation Non-invasive biochemical analysis
US7330747B2 (en) 2005-06-07 2008-02-12 Chemimage Corporation Invasive chemometry
EP1734359A1 (en) * 2005-06-18 2006-12-20 Roche Diagnostics GmbH RAMAN spectroscopic analysis method and system therefor
WO2007014173A2 (en) * 2005-07-22 2007-02-01 Massachusetts Institute Of Technology Intrinsic raman spectroscopy
JP4749890B2 (en) * 2006-02-27 2011-08-17 株式会社四国総合研究所 Hydrogen gas visualization method and system using Raman scattered light
KR20100110305A (en) * 2007-11-20 2010-10-12 엠비알 옵티컬 시스템즈 지엠비에치 & 코. 케이지 Method and measuring device for collecting indicative signals relating to the concentration of a substance in an examination area, in particular living tissue
CA2724973C (en) 2008-05-20 2015-08-11 University Health Network Device and method for fluorescence-based imaging and monitoring
US8467053B2 (en) * 2008-06-03 2013-06-18 The Research Foundation Of State University Of New York Identification of body fluids using raman spectroscopy
US9846117B2 (en) * 2009-06-12 2017-12-19 Spectrasensors, Inc. Optical absorbance measurements with self-calibration and extended dynamic range
US9662047B2 (en) 2010-08-05 2017-05-30 Massachusetts Institute Of Technology Portable raman diagnostic system
US9046363B2 (en) * 2012-04-27 2015-06-02 SATOP GmbH Using multispectral satellite data to determine littoral water depths despite varying water turbidity
US8982338B2 (en) * 2012-05-31 2015-03-17 Thermo Scientific Portable Analytical Instruments Inc. Sample analysis
US10722292B2 (en) 2013-05-31 2020-07-28 Covidien Lp Surgical device with an end-effector assembly and system for monitoring of tissue during a surgical procedure
PL3171765T3 (en) 2014-07-24 2022-01-03 University Health Network Collection and analysis of data for diagnostic purposes
US9459201B2 (en) 2014-09-29 2016-10-04 Zyomed Corp. Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing
WO2016157156A1 (en) 2015-04-02 2016-10-06 Livspek Medical Technologies Inc. Method and apparatus for a spectral detector for noninvasive detection and monitoring of a variety of biomarkers and other blood constituents in the conjunctiva
US9995859B2 (en) 2015-04-14 2018-06-12 California Institute Of Technology Conformal optical metasurfaces
GB201511574D0 (en) * 2015-07-01 2015-08-12 Stfc Science & Technology Clinical thermometer
US10881336B2 (en) * 2015-08-21 2021-01-05 California Institute Of Technology Planar diffractive device with matching diffraction spectrum
FR3046048B1 (en) * 2015-12-23 2020-03-27 Bioserenity DEVICE AND METHOD FOR MEASURING THE CONCENTRATION OF A BLOOD COMPOUND
US10670782B2 (en) 2016-01-22 2020-06-02 California Institute Of Technology Dispersionless and dispersion-controlled optical dielectric metasurfaces
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
DE102016111747B4 (en) * 2016-06-27 2020-10-01 Forschungsverbund Berlin E.V. Method and device for Raman spectroscopy
GB201618260D0 (en) 2016-10-28 2016-12-14 Science And Tech Facilities Council The Detection of pH
KR20180051196A (en) * 2016-11-08 2018-05-16 삼성전자주식회사 Spectrometer, apparatus and method for measuring bio-information
US10488651B2 (en) 2017-04-10 2019-11-26 California Institute Of Technology Tunable elastic dielectric metasurface lenses
US11199449B1 (en) * 2017-09-26 2021-12-14 The United States Of America, As Represented By The Secretary Of The Navy Automated noncontact method to discriminate whether cooling or heating is occurring
US11627895B2 (en) 2018-08-10 2023-04-18 Samsung Electronics Co., Ltd. Apparatus and method for estimating analyte concentration, and apparatus and method for generating analyte concentration estimation model
KR102574088B1 (en) * 2018-08-10 2023-09-04 삼성전자주식회사 Apparatus and method for estimating analyte concentration, Apparatus and method for generating analyte concentration estimation model
US20200163597A1 (en) * 2018-11-27 2020-05-28 Cercacor Laboratories, Inc. Assembly for medical monitoring device with multiple physiological sensors
DE102018130582A1 (en) * 2018-11-30 2020-06-04 Forschungsverbund Berlin E.V. Device and method for Raman spectroscopy
JPWO2020195199A1 (en) * 2019-03-27 2020-10-01
US11269203B2 (en) 2020-01-23 2022-03-08 Hong Kong Applied Science And Technology Institute Company Limited Multifocal system with polarization-independent focusing
US11408825B2 (en) 2020-08-28 2022-08-09 Hong Kong Applied Science and Technology Research Institute Company Limited Forensic detector and the system thereof
CN113925504B (en) * 2021-10-21 2024-02-13 浙江澍源智能技术有限公司 Arterial blood Raman spectrum detection device and method based on pulse wave
DE102022124375B3 (en) * 2022-09-22 2023-09-28 Ferdinand-Braun-Institut gGmbH, Leibniz- Institut für Höchstfrequenztechnik Device and method for Raman spectroscopy

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06105190B2 (en) * 1988-03-31 1994-12-21 工業技術院長 Signal analyzer
US5243983A (en) * 1990-12-14 1993-09-14 Georgia Tech Research Corporation Non-invasive blood glucose measurement system and method using stimulated raman spectroscopy
CA2104960C (en) 1991-02-26 2005-04-05 Richard P. Rava Systems and methods of molecular spectroscopy to provide for the diagnosis of tissue
EP0557658B1 (en) * 1992-02-24 1997-05-07 Hewlett-Packard Company Raman spectroscopy of respiratory gases
US5515847A (en) * 1993-01-28 1996-05-14 Optiscan, Inc. Self-emission noninvasive infrared spectrophotometer
US5553616A (en) 1993-11-30 1996-09-10 Florida Institute Of Technology Determination of concentrations of biological substances using raman spectroscopy and artificial neural network discriminator
WO1995031928A1 (en) * 1994-05-20 1995-11-30 Kuenst Hermann Transcutaneous, non-bloody determination of the concentration of substances in the blood
US5713364A (en) * 1995-08-01 1998-02-03 Medispectra, Inc. Spectral volume microprobe analysis of materials
DE19538372A1 (en) * 1995-10-14 1997-04-17 Laser & Med Tech Gmbh Non-invasive glucose measurement
AU1401599A (en) * 1997-11-12 1999-05-31 Lightouch Medical, Inc. Method for non-invasive measurement of an analyte
US6070093A (en) 1997-12-02 2000-05-30 Abbott Laboratories Multiplex sensor and method of use
US6389306B1 (en) * 1998-04-24 2002-05-14 Lightouch Medical, Inc. Method for determining lipid and protein content of tissue
EP1073366B1 (en) * 1998-04-24 2004-06-23 Lightouch Medical, Inc. Apparatus and method for thermal tissue modulation
US6064897A (en) * 1998-06-01 2000-05-16 Abbott Laboratories Sensor utilizing Raman spectroscopy for non-invasive monitoring of analytes in biological fluid and method of use
ES2185374T3 (en) * 1998-07-07 2003-04-16 Lightouch Medical Inc TISSULAR MODULATION PROCEDURE FOR IN VIVO QUANTITATIVE SPECTROSCOPIC ANALYSIS, NOT INVESTOR OF FABRICS.
EP1093343A4 (en) * 1998-07-13 2005-04-27 Los Angeles Childrens Hospital Non-invasive glucose monitor

Also Published As

Publication number Publication date
EP1292220A1 (en) 2003-03-19
HK1055552B (en) 2007-08-24
JP3715241B2 (en) 2005-11-09
US20030176777A1 (en) 2003-09-18
WO2001091632A1 (en) 2001-12-06
DE50111644D1 (en) 2007-01-25
US6868285B2 (en) 2005-03-15
ATE347852T1 (en) 2007-01-15
HK1055552A1 (en) 2004-01-16
DE10027100C2 (en) 2002-08-08
EP1292220B1 (en) 2006-12-13
DE10027100A1 (en) 2001-12-20
JP2003534087A (en) 2003-11-18

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