WO2020195199A1 - Contact lens, aqueous humor raman spectroscopic measurement device, aqueous humor raman spectroscopic measurement system, and aqueous humor raman spectroscopic measurement method - Google Patents

Contact lens, aqueous humor raman spectroscopic measurement device, aqueous humor raman spectroscopic measurement system, and aqueous humor raman spectroscopic measurement method Download PDF

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Publication number
WO2020195199A1
WO2020195199A1 PCT/JP2020/004395 JP2020004395W WO2020195199A1 WO 2020195199 A1 WO2020195199 A1 WO 2020195199A1 JP 2020004395 W JP2020004395 W JP 2020004395W WO 2020195199 A1 WO2020195199 A1 WO 2020195199A1
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Prior art keywords
light
contact lens
guide window
eye
incident
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PCT/JP2020/004395
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French (fr)
Japanese (ja)
Inventor
卓 木下
慎 久保田
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株式会社シード
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Application filed by 株式会社シード filed Critical 株式会社シード
Priority to JP2020519450A priority Critical patent/JPWO2020195199A1/ja
Publication of WO2020195199A1 publication Critical patent/WO2020195199A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A61B3/125—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes with contact lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes

Definitions

  • the present invention relates to a contact lens, an aqueous humor Raman spectroscopic measurement device, an aqueous humor Raman spectroscopic measurement system, and an aqueous humor Raman spectroscopic measurement method.
  • Non-Patent Document 1 discloses a technique for non-invasively inspecting an eye to be inspected.
  • this technique as described in FIGURE 3 of Non-Patent Document 1, light is incidented laterally from the nasal side or the ear side of the eye to be inspected, and the inside of the aqueous humor is the axis of the eye to be inspected (the apex of the cornea and the fovea centralis). It is transmitted along a direction that is substantially orthogonal to the direction of the line).
  • Non-Patent Document 1 In order to realize the optical path shown by, it is necessary to control the incident angle of light with respect to the eye to be inspected with an error smaller than 1 °, which is considered to be difficult to realize.
  • the present invention has been made in view of the above, and is a contact lens, an aqueous humor Raman spectrophotometer, and an aqueous humor Raman spectrophotometric measurement capable of non-invasively analyzing substances contained in the aqueous humor of an eye to be inspected. It provides a system and an aqueous humor Raman spectrometric measurement method.
  • the contact lens according to the present invention is a contact lens having a concave inner surface in contact with an eye to be inspected and a convex outer surface, and the contact lens is provided from the outer surface to the inner surface side.
  • the direction in which light incident from a direction substantially orthogonal to the lens geometric center axis is formed so as to be substantially orthogonal to the lens geometric center axis in the aqueous humor of the eye to be inspected wearing the contact lens. It is characterized by providing an incident side light guide window that guides the light so as to proceed along the line.
  • the contact lens according to the present invention is characterized in that, in the above invention, the incident side light guide window has an angle formed by the lens geometric center axis of 8 ° or more and 28 ° or less.
  • the contact lens according to the present invention is characterized in that, in the above invention, the refractive index of the contact lens is 1.36 or more and 1.46 or less.
  • the contact lens according to the present invention is the exit side light guide window formed at a position line-symmetrical with the incident side light guide window with the lens geometric center axis as the axis of symmetry in the above invention. It is provided with a light emitting side light guide window which is formed by being cut out from the outer surface to the inner surface side and guides the light transmitted through the bunch of water of the eye to be inspected wearing the contact lens to the outside of the contact lens. It is characterized by.
  • the contact lens according to the present invention is characterized in that, in the above invention, it is arranged around the incident side light guide window and includes a light shielding portion that blocks light.
  • the contact lens according to the present invention is characterized in that, in the above invention, a through hole is formed in the central portion of the contact lens.
  • the aqueous Raman spectroscopic measuring apparatus transmits the first light source unit that emits excitation light, a half mirror arranged in a direction substantially orthogonal to the optical axis of the excitation light, and the half mirror.
  • the excitation light is arranged on one of the light paths of the scattered light due to the substance contained in the aqueous humor of the eye to be inspected or the scattered light reflected by the half mirror, and the Rayleigh scattered light contained in the scattered light.
  • a filter that blocks light of the same wavelength and transmits Raman scattered light contained in the scattered light, a spectroscope that spectroscopically measures the light transmitted through the filter, and the scattered light or the half mirror transmitted through the half mirror. It is characterized in that it is arranged on the other optical path of the scattered light reflected by the above, and includes a second light source unit for emitting light to fix the eye to be inspected.
  • the aqueous humor Raman spectroscopic measuring apparatus is characterized in that, in the above invention, the second light source unit emits light having a wavelength shaded by the filter.
  • the aqueous humor Raman spectroscopic measuring apparatus is characterized in that, in the above invention, the second light source unit emits white light.
  • the optical axis of the light emitted by the second light source unit is incident on the spectroscope between the eye to be inspected and the half mirror. It is characterized by being deviated from the optical axis of light by approximately 5 °.
  • the aqueous Raman spectroscopic measurement system is a contact lens having a concave inner surface in contact with an eye to be inspected and a convex outer surface, and is formed by being cut out from the outer surface to the inner surface side.
  • Light that is incident from a direction substantially orthogonal to the geometric center axis of the lens travels along a direction substantially orthogonal to the geometric center axis of the lens in the aqueous humor of the eye to be inspected wearing the contact lens.
  • a contact lens having an incident side light guide window, a first light source unit that emits excitation light so as to be incident on the incident side light guide window from a direction substantially orthogonal to the lens geometric center axis, and the excitation light.
  • the half mirror is arranged in a direction substantially orthogonal to the optical axis of the above, and the excitation light transmitted through the half mirror is reflected by the scattered light by the substance contained in the aqueous chamber of the eye to be inspected or the half mirror.
  • a filter that is arranged on one of the scattered light paths, blocks light having the same wavelength as Rayleigh scattered light contained in the scattered light, and transmits Raman scattered light contained in the scattered light, and the filter.
  • the spectroscope that spectroscopically measures the transmitted light and the scattered light transmitted through the half mirror or the scattered light reflected by the half mirror are arranged on the other optical path, and emit light to emit the light to the eye to be inspected. It is characterized by including a second light source unit for fixing the image.
  • the aqueous Raman spectroscopic measurement method is a contact lens having a concave inner surface in contact with an eye to be inspected and a convex outer surface, and is formed by being cut out from the outer surface to the inner surface side.
  • Light that is incident from a direction substantially orthogonal to the geometric center axis of the lens travels along a direction substantially orthogonal to the geometric center axis of the lens in the aqueous humor of the eye to be inspected wearing the contact lens.
  • the contact lens is formed at a position line-symmetrical with the light guide window on the incident side with the geometric center axis of the lens as the axis of symmetry.
  • a side light guide window which is formed by being cut out from the outer surface to the inner surface side, and guides light transmitted through the aqueous humor of the eye to be inspected wearing the contact lens to the outside of the contact lens.
  • the transmission inspection light having a light guide window on the exit side and having a transmission inspection light having a light intensity smaller than that of the excitation light is emitted from the first light source unit before the measurement step, and the transmission inspection is incident on the light guide window on the incident side. It is characterized by including a transmission inspection step for inspecting whether or not light is emitted from the light emitting side light guide window.
  • a contact lens an aqueous humor Raman spectrometric apparatus, an aqueous humor Raman spectrometric measurement system, and an aqueous humor Raman spectrometric measurement method capable of non-invasively analyzing substances contained in the aqueous humor of an eye to be inspected.
  • an aqueous humor Raman spectrometric measurement method capable of non-invasively analyzing substances contained in the aqueous humor of an eye to be inspected.
  • FIG. 1 is a schematic diagram of an aqueous humor Raman spectroscopic measurement system according to an embodiment of the present invention.
  • FIG. 2 is a cross-sectional view showing a contact lens according to an embodiment of the present invention.
  • FIG. 3 is a view taken along the line B1 of FIG.
  • FIG. 4 is a schematic view of a contact lens worn on the eye to be inspected.
  • FIG. 5 is a diagram showing physical property values used in the simulation.
  • FIG. 6 is a diagram showing the state of refraction at the interface.
  • FIG. 7 is a diagram showing an optical path of light when the inclination angles of the light guide window on the incident side and the light guide window on the exit side are changed.
  • FIG. 1 is a schematic diagram of an aqueous humor Raman spectroscopic measurement system according to an embodiment of the present invention.
  • FIG. 2 is a cross-sectional view showing a contact lens according to an embodiment of the present invention.
  • FIG. 3 is a view taken along the
  • FIG. 8 is a diagram showing an optical path of light when the inclination angles of the light guide window on the incident side and the light guide window on the exit side are changed.
  • FIG. 9 is a diagram showing an optical path of light when the inclination angles of the light guide window on the incident side and the light guide window on the exit side are changed.
  • FIG. 10 is a diagram showing an optical path of light when the positions of the light guide window on the incident side and the light guide window on the exit side are changed.
  • FIG. 11 is a diagram showing an optical path of light when the refractive index of a contact lens is changed.
  • FIG. 12 is a diagram showing an optical path of light when the refractive index of a contact lens is changed.
  • FIG. 13 is a diagram showing an optical path of light when the angle of incidence on the contact lens is changed.
  • FIG. 14 is a diagram showing an optical path of light when the angle of incidence on a contact lens is changed.
  • FIG. 15 is a cross-sectional view showing the contact lens according to the modified example 1-1.
  • FIG. 16 is a view taken along the line B2 of FIG.
  • FIG. 17 is a cross-sectional view showing the contact lens according to the modified example 1-2.
  • FIG. 18 is a view taken along the line B3 of FIG.
  • FIG. 19 is a cross-sectional view showing the contact lens according to the modified example 1-3.
  • FIG. 20 is a view taken along the line B4 of FIG.
  • FIG. 21 is a cross-sectional view showing the contact lens according to the modified example 1-4.
  • FIG. 22 is a view taken along the line B5 of FIG. 21.
  • FIG. 23 is a cross-sectional view showing the contact lens according to the modified example 1-5.
  • FIG. 24 is a view taken along the line B6 of FIG. 23.
  • FIG. 25 is a cross-sectional view showing the contact lens according to the modified example 1-6.
  • FIG. 26 is a view taken along the line B7 of FIG. 25.
  • FIG. 27 is a cross-sectional view showing the contact lens according to the modified example 1-7.
  • FIG. 28 is a view taken along the line B8 of FIG. 27.
  • FIG. 29 is a cross-sectional view showing the contact lens according to the modified example 1-8.
  • FIG. 30 is a view taken along the line B9 of FIG. 29.
  • FIG. 31 is a schematic diagram of the aqueous humor Raman spectroscopic measurement system according to the modified example 2-1.
  • the details of the contact lens, the aqueous humor Raman spectroscopic measurement device, the aqueous humor Raman spectroscopic measurement system, and the aqueous humor Raman spectroscopic measurement method of the present invention will be described in accordance with the embodiments, but these limit the present invention. It's not a thing.
  • FIG. 1 is a schematic diagram of an aqueous humor Raman spectroscopic measurement system according to an embodiment of the present invention.
  • the aqueous humor Raman spectroscopic measurement system 100 performs measurement for analyzing a substance contained in the aqueous humor 12 inside the cornea 11 of the eye 10 to be examined by Raman spectroscopy.
  • the Raman spectroscopic measurement system 100 irradiates the contact lens 1 worn on the eye 10 to be inspected and the contact lens 1 with excitation light, and Raman scattering from the tuft 12 of the eye 10 to be inspected.
  • a bunch of Raman spectroscopic measurement device 20 for spectroscopically measuring light is provided.
  • FIG. 2 is a cross-sectional view showing a contact lens according to an embodiment of the present invention.
  • FIG. 3 is a view taken along the line B1 of FIG.
  • FIG. 2 is a cross-sectional view corresponding to line C1-C1 of FIG.
  • the contact lens 1 includes a concave inner surface 1a in contact with the eye 10 to be inspected and a convex outer surface 1b. Further, the contact lens 1 includes an incident side light guide window 2, an exit side light guide window 3, and an edge portion 4.
  • the contact lens 1 is a soft contact lens made of, for example, pHEMA (polyhydroxyethyl methacrylate) and has a refractive index of 1.406. Further, the contact lens 1 may be a soft contact lens made of SHG (silicone hydrogel), and in this case, the refractive index is 1.385. However, the contact lens 1 may be a hard contact lens.
  • pHEMA polyhydroxyethyl methacrylate
  • SHG silicone hydrogel
  • the contact lens 1 is preferably a toric contact lens.
  • the contact lens 1 is such that the light guide window 2 on the incident side is located on the ear side of the subject and the light guide window 3 on the exit side is located on the nose side of the subject by blinking. Rotates.
  • the light guide window 2 on the incident side is formed by being cut out from the outer surface 1b to the inner surface 1a side, and the light incident from a direction substantially orthogonal to the lens geometric central axis (hereinafter, referred to as “central axis A1”) is the said.
  • central axis A1 the lens geometric central axis
  • the light is guided so as to proceed in a direction substantially orthogonal to the central axis A1.
  • the incident side light guide window 2 the light enters the inside of the eye 10 to be inspected and prevents the eye 10 to be injured. be able to.
  • the exit side light guide window 3 is formed at a position line-symmetrical with the incident side light guide window 2 with the central axis A1 as the axis of symmetry. Further, the light emitting side light guide window 3 is formed by being cut out from the outer surface 1b to the inner surface 1a side, and the light transmitted through the aqueous humor 12 of the eye 10 to be inspected wearing the contact lens 1 is transmitted to the outside of the contact lens 1. Guide light. By guiding the light transmitted through the aqueous humor 12 to the outside of the contact lens 1 by the light emitting window 3, it is possible to more reliably prevent the light from damaging the eye 10 to be inspected.
  • the edge portion 4 is a thin portion formed incidentally to the incident side light guide window 2 and the exit side light guide window 3.
  • FIG. 4 is a schematic view of a contact lens worn on the eye to be inspected.
  • the horizontal axis orthogonal to the central axis A1 is x
  • the vertical axis along the central axis A1 is y
  • the incident side light guide window 2 and the exit side light guide window 3 are formed by the central axis A1.
  • the angle was ⁇ .
  • the radius r c to the end of the entrance-side light guide window 2 and the exit side guide window 3 was set to be 5.65 mm.
  • the value of the radius r c, based on the average value of the cornea radius men is 5.5 mm, the light incident from the incident side light guide window 2 is set to be incident on the cornea.
  • the contact lens 1 is worn on the surface of the cornea 11 of the eye 10 to be inspected.
  • the curves representing the corneal epithelium 11a and the corneal endothelium 11b can be represented by the following equations (1), respectively.
  • R is the radius of curvature
  • K is the cornic constant
  • A, B, C, and D are coefficients.
  • FIG. 5 is a diagram showing physical property values used in the simulation. As shown in FIG. 5, if the physical property values of the corneal epithelium 11a, the corneal endothelium 11b, and the outer surface 1b are determined, the figure shown in FIG. 4 can be drawn. Note that D is the y-intercept in FIG. Further, the origin O in FIG. 4 is the center of rotation in the adduction or abduction of the eye 10 to be inspected.
  • FIG. 6 is a diagram showing the state of refraction at the interface.
  • the vector i 1 corresponding to the incident light
  • the normal vector N at the interface and the normal vector N
  • the vector i 2 corresponding to the light refracted at the interface using the angle ⁇ formed by the vector i 1 is expressed by Snell's law shown in the following equation (3).
  • the refractive index n air of air is 1.00
  • the refractive index n c of contact lens 1 is 1.406
  • the refractive index n cor of the cornea is 1.37
  • the refractive index n ah of aqueous humor is 1. It was set to 1.33.
  • the beam diameter of the incident light was 400 ⁇ m.
  • the inclination angle ⁇ of the incident side light guide window 2 and the exit side light guide window 3 is 15 °.
  • the optical path of the light incident from the incident side light guide window 2 is the optical path along the most horizontal direction.
  • the inclination angle ⁇ of the incident side light guide window 2 and the exit side light guide window 3 is 8 °.
  • the light incident from the incident side light guide window 2 is guided to the outside of the contact lens 1 from the exit side light guide window 3.
  • the inclination angle ⁇ of the incident side light guide window 2 and the exit side light guide window 3 is smaller than 8 °, the light incident from the incident side light guide window 2 is transmitted from the exit side light guide window 3 to the outside of the contact lens 1. Cannot guide light to.
  • the inclination angle ⁇ of the incident side light guide window 2 and the exit side light guide window 3 is 28 °.
  • the light incident from the incident side light guide window 2 is guided to the outside of the contact lens 1 from the exit side light guide window 3.
  • the inclination angle ⁇ of the incident side light guide window 2 and the exit side light guide window 3 is larger than 28 °, the light incident from the incident side light guide window 2 is transmitted from the exit side light guide window 3 to the outside of the contact lens 1. Cannot guide light to.
  • the inclination angle ⁇ of the incident side light guide window 2 and the exit side light guide window 3 is most preferably 15 °, and the inclination angle ⁇ is 8 ° or more. It is preferably 28 ° or less. In this case, the light incident from the incident side light guide window 2 is guided to the outside from the exit side light guide window 3, so that the safety is high.
  • FIG. 10 is a diagram showing an optical path of light when the positions of the light guide window on the incident side and the light guide window on the exit side are changed.
  • the radius r c was set to 4.65 mm.
  • the optical path of the light incident on the incident side light guide window 2 from the horizontal direction is the optical path along the most horizontal direction.
  • the radius r c by varying the radius r c, the light incident from the incident side light guide window 2 is guided to the outside from the outgoing side light guide window 3 High sex.
  • FIGS. 11 and 12 are diagrams showing the optical path of light when the refractive index of the contact lens is changed.
  • the refractive index of the contact lens 1 is 1.36. In this case, the light incident from the incident side light guide window 2 is guided to the outside of the contact lens 1 from the exit side light guide window 3. If the refractive index of the contact lens 1 is smaller than 1.36, the light incident from the incident side light guide window 2 cannot be guided to the outside of the contact lens 1 from the exit side light guide window 3.
  • the refractive index of the contact lens 1 is 1.46. In this case, the light incident from the incident side light guide window 2 is guided to the outside of the contact lens 1 from the exit side light guide window 3. If the refractive index of the contact lens 1 is larger than 1.46, the light incident from the incident side light guide window 2 cannot be guided to the outside of the contact lens 1 from the exit side light guide window 3.
  • the refractive index of the contact lens 1 is preferably 1.36 or more and 1.46 or less.
  • the light incident from the incident side light guide window 2 is guided to the outside from the exit side light guide window 3, so that the safety is high.
  • FIG. 13 and 14 are diagrams showing the optical path of light when the angle of incidence on the contact lens is changed.
  • the inclination angle ⁇ of the incident side light guide window 2 and the exit side light guide window 3 is 0 °, and the incident angle ⁇ of light is ⁇ 5 °.
  • the incident angle ⁇ is positive on the ear side of the subject and negative on the side opposite to the ear side of the subject. In this case, the light incident from the incident side light guide window 2 is guided to the outside of the contact lens 1 from the exit side light guide window 3.
  • the angle of inclination ⁇ of the light guide window 2 on the incident side and the light guide window 3 on the exit side is 30 °, and the incident angle ⁇ of light is 4 °.
  • the light incident from the incident side light guide window 2 is guided to the outside of the contact lens 1 from the exit side light guide window 3.
  • the incident side light guide window 2 and the exit side light guide window 3 As described above, although it depends on the inclination angle ⁇ of the incident side light guide window 2 and the exit side light guide window 3, when the light incident angle ⁇ is -4 ° or more and 5 ° or less, the incident side light guide Since the light incident from the window 2 is guided to the outside through the light emitting side light guide window 3, the safety is high. That is, even if the incident angle ⁇ of the light with respect to the contact lens 1 deviates from the horizontal direction, safety is maintained as long as the light is small.
  • the Fusamizu Raman spectrophotometer 20 includes a first light source unit 21, a light-shielding member 22, a half mirror 23, an objective lens 24, a notch filter 25, a condensing lens 26, and light. It includes a fiber coupler 27, an optical fiber 28, a spectroscope 29, a second light source unit 30, and a camera 31.
  • the aqueous humor Raman spectroscopic measurement device 20 measures the light L3 in a direction substantially orthogonal to the excitation light L1 emitted from the first light source unit 21. This is because the Raman scattered light has the same light intensity regardless of the direction measured, whereas the Rayleigh scattered light has the weakest light intensity in the direction substantially orthogonal to the excitation light, so that the Raman scattered light is efficiently used. This is because it can be measured. Even if a light absorber that absorbs this light is arranged on the optical path of the light L2 that has passed through the bunch of water 12 of the eye 10 to be inspected and is guided to the outside of the contact lens 1 by the light emitting side light guide window 3. Good.
  • the first light source unit 21 emits excitation light L1 for spectroscopically measuring Raman scattered light in the aqueous humor 12 of the eye 10 to be inspected. Further, the first light source unit 21 emits transmission inspection light having a light intensity smaller than that of the excitation light L1. The transmission inspection light is used for inspecting whether or not the transmission inspection light incident on the incident side light guide window 2 is emitted from the exit side light guide window 3 before the measurement is performed.
  • the wavelengths of the excitation light L1 and the transmission inspection light are, for example, 532 nm, but are not particularly limited.
  • the transmission inspection light preferably has the same wavelength as the excitation light.
  • the first light source unit 21 may be a light source that emits light having a predetermined wavelength, and is, for example, an LED (Light Emitting Diode).
  • the light-shielding member 22 is made of an elastic member such as rubber.
  • the light-shielding member 22 covers the periphery of the eye 10 to be inspected and shields external light from entering the housing of the aqueous humor Raman spectroscopic measurement device 20.
  • the half mirror 23 is arranged in a direction substantially orthogonal to the optical axis of the excitation light L1.
  • the half mirror 23 transmits a part of the scattered light L3 by the substance contained in the aqueous humor 12 of the eye 10 to be inspected for the excitation light L1 and reflects a part of the scattered light L3.
  • the objective lens 24 collects scattered light L3.
  • the notch filter 25 corresponds to the filter according to the present invention.
  • the notch filter 25 is a band-stop filter that is arranged on the optical path of the light L4 that has passed through the half mirror 23 and selectively blocks light having the same wavelength as the Rayleigh scattered light contained in the scattered light L3. Therefore, the notch filter 25 blocks the Rayleigh scattered light contained in the scattered light L3 and transmits the Raman scattered light.
  • the filter may be a filter that selectively blocks light having the same wavelength as the Rayleigh scattered light contained in the scattered light L3 and transmits the Raman scattered light contained in the scattered light L3. For example, when measuring Stoke Raman scattering, a filter that transmits on the wavelength side longer than the excitation light L1 may be used.
  • a filter that transmits on the wavelength side shorter than the excitation light L1 may be used.
  • a bandpass filter that selectively transmits Raman scattered light may be used.
  • the condensing lens 26 condenses the light L4 that has passed through the notch filter 25 and couples it to the optical fiber coupler 27.
  • the optical fiber coupler 27 guides the light L4 collected by the condensing lens 26 to the optical fiber 28.
  • the optical fiber 28 guides the light guided to the optical fiber coupler 27.
  • the spectroscope 29 spectroscopically measures the light transmitted through the filter.
  • the light collected by the condensing lens 26 may be directly incident on the spectroscope. In this case, the optical fiber coupler 27 and the optical fiber 28 are unnecessary.
  • the second light source unit 30 is arranged on the optical path of the scattered light reflected by the half mirror 23, and emits the light to fix the eye 10 to be inspected. That is, the second light source unit can be used as a fixation target for fixing the eye 10 to be inspected.
  • the optical axis of the light E emitted by the second light source unit 30 between the eye 10 to be inspected and the half mirror 23 is deviated by approximately 5 ° from the optical axis of the light L3 incident on the spectroscope 29.
  • the line of sight (the line of sight of the eye 10 to be inspected and the fovea centralis) that is substantially the same as the light E with respect to the axis of the eye 10 to be inspected (the line connecting the apex of the cornea 11 and the fovea centralis). This is because the line connecting the lights) is shifted inward (nose side) by 5 °.
  • the wavelength of the light emitted from the second light source unit 30 is a wavelength shaded by the notch filter 25, for example, 532 nm. Further, the second light source unit 30 may be capable of emitting white light. In this case, the second light source unit 30 can be used as the illumination when observing the state of the eye 10 to be inspected by the camera 31.
  • the camera 31 captures the eye 10 to be inspected.
  • the state of the eye 10 to be inspected such as whether the conjunctiva of the eye to be inspected 10 is hyperemic or the eyelashes do not affect the measurement.
  • the contact lens 1 is worn on the eye 10 to be inspected.
  • the contact lens 1 is a toric contact lens
  • the incident side light guide window 2 is located on the subject's ear side
  • the exit side light guide window 3 is located on the subject's nose side by blinking.
  • the contact lens 1 rotates.
  • the excitation light emitted from the first light source unit 21 is aligned so as to enter the incident side light guide window 2 from a direction substantially orthogonal to the lens geometric center axis (alignment step). Specifically, by adjusting the relative positions of the eye 10 to be inspected and the aqueous humor Raman spectroscopic measurement device 20, the optical axis of the eye 10 to be inspected and the optical path of the light L3 are substantially aligned.
  • fixation step Further, light is emitted from the second light source unit 30 to the eye 10 to be inspected to fix the eye to be inspected (fixation step).
  • the transmission inspection light is emitted from the first light source unit 21, and it is inspected whether or not the transmission inspection light incident on the incident side light guide window 2 is emitted from the exit side light guide window 3 (transmission inspection step).
  • the excitation light is emitted from the first light source unit 21, and the light transmitted through the notch filter 25 is spectrally measured by the spectroscope 29 (measurement step). ).
  • the substance contained in the aqueous humor 12 of the eye 10 to be inspected can be analyzed.
  • the Raman scattered light from the aqueous humor 12 of the eye 10 to be inspected can be measured non-invasively by using the contact lens 1 provided with the incident side light guide window 2. .. Therefore, according to the embodiment, it is possible to analyze the substance contained in the aqueous humor 12 of the eye 10 to be examined non-invasively.
  • the incident side light guide window 2 and the exit side light guide window 3 are formed so as to diagonally intersect the optical axis of the excitation light L1, the incident side light guide window 2 and It is possible to prevent the reflected light from the light emitting side light guide window 3 from returning to the first light source unit 21 and making the operation of the first light source unit 21 unstable.
  • the light guide window provided in the container is the light of the excitation light. Since it is orthogonal to the axis, the reflected light in the light guide window returns to the first light source unit 21, and the operation of the first light source unit 21 may become unstable.
  • FIG. 15 is a cross-sectional view showing the contact lens according to the modified example 1-1.
  • FIG. 16 is a view taken along the line B2 of FIG.
  • FIG. 15 is a cross-sectional view corresponding to line C2-C2 of FIG.
  • the axis A2 is the lens geometric center axis of the contact lens 1A.
  • the contact lens 1A has an incident side light guide window 2 and does not have an exit side light guide window. As described above, the contact lens does not have to have a light guide window on the exit side.
  • FIG. 17 is a cross-sectional view showing the contact lens according to the modified example 1-2.
  • FIG. 18 is a view taken along the line B3 of FIG.
  • FIG. 17 is a cross-sectional view corresponding to line C3-C3 of FIG.
  • the axis A3 is the lens geometric center axis of the contact lens 1B.
  • the contact lens 1B includes a series of light guide windows 2B and an edge 4B in an annular shape.
  • the light guide window 2B also serves as a light guide window on the incident side and a light guide window on the exit side.
  • the contact lens 1B does not have to be a toric contact lens because the contact lens 1B may rotate in the eye 10 to be inspected.
  • FIG. 19 is a cross-sectional view showing the contact lens according to the modified example 1-3.
  • FIG. 20 is a view taken along the line B4 of FIG.
  • FIG. 19 is a cross-sectional view corresponding to line C4-C4 of FIG.
  • the axis A4 is the lens geometric center axis of the contact lens 1C.
  • the contact lens 1C includes a semicircular incident side light guide window 2C and an edge portion 4C. As described above, the contact lens does not have to have a light guide window on the exit side.
  • FIG. 21 is a cross-sectional view showing the contact lens according to the modified example 1-4.
  • FIG. 22 is a view taken along the line B5 of FIG. 21.
  • FIG. 21 is a cross-sectional view corresponding to line C5-C5 of FIG.
  • the axis A5 is the lens geometric center axis of the contact lens 1D.
  • the contact lens 1D includes an exit side light guide window 3D having a different inclination angle from the incident side light guide window 2.
  • the tilt angle ⁇ of the light emitting window 3D is larger than the tilt angle ⁇ of the light guide window 2 on the incident side.
  • FIG. 23 is a cross-sectional view showing the contact lens according to the modified example 1-5.
  • FIG. 24 is a view taken along the line B6 of FIG. 23.
  • FIG. 23 is a cross-sectional view corresponding to line C6-C6 of FIG. 24.
  • the axis A6 is the lens geometric center axis of the contact lens 1E.
  • the contact lens 1E includes a semicircular incident side light guide window 2C and a semicircular exit side light guide window 3E having different inclination angles. Further, the contact lens 1E includes an edge portion 4E formed incidentally to the light emitting side light guide window 3E.
  • the inclination angle ⁇ of the light emitting window 3E is larger than the inclination angle ⁇ of the light guide window 2C on the incident side.
  • FIG. 25 is a cross-sectional view showing the contact lens according to the modified example 1-6.
  • FIG. 26 is a view taken along the line B7 of FIG. 25.
  • FIG. 25 is a cross-sectional view corresponding to line C7-C7 of FIG.
  • the axis A7 is the lens geometric center axis of the contact lens 1F.
  • the contact lens 1F includes a continuously formed incident side light guide window 2F and an exit side light guide window 3F. Further, the contact lens 1F includes an incident side light guide window 2F and an edge portion 4F formed incidentally to the exit side light guide window 3F.
  • the light guide window 2F on the incident side is formed in the region indicated by the central angle ⁇ , and the inclination angle is constant at ⁇ in this portion.
  • the inclination angle gradually increases from the portion connected to the light guide window 2F on the incident side, and the maximum value is ⁇ at the end facing the light guide window 2F on the incident side. As a result, it is possible to prevent the generation of stray light due to the light from the light emitting window 3E on the exit side traveling in the direction away from the subject and irradiating the eyelashes and the like.
  • FIG. 27 is a cross-sectional view showing the contact lens according to the modified example 1-7.
  • FIG. 28 is a view taken along the line B8 of FIG. 27.
  • FIG. 27 is a cross-sectional view corresponding to line C8-C8 of FIG. 28.
  • the axis A8 is the lens geometric center axis of the contact lens 1G.
  • the contact lens 1G is arranged around the incident side light guide window 2 and the exit side light guide window 3, and includes a light shielding portion 5G that blocks light.
  • the excitation light from the first light source unit 21 deviates from the incident side light guide window 2
  • the excitation light is shielded by the light shielding unit 5G, so that the safety is high.
  • the light shielding portion 5G blocks the light, so that it is possible to prevent unexpected stray light from being generated.
  • FIG. 29 is a cross-sectional view showing the contact lens according to the modified example 1-8.
  • FIG. 30 is a view taken along the line B9 of FIG. 29.
  • FIG. 29 is a cross-sectional view corresponding to line C9-C9 of FIG.
  • the axis A9 is the lens geometric center axis of the contact lens 1H.
  • a through hole 6H is formed in the central portion of the contact lens 1H.
  • the Raman scattered light in the aqueous humor 12 is prevented from being attenuated by the contact lens 1H, and the measurement accuracy is improved.
  • FIG. 31 is a schematic diagram of the aqueous humor Raman spectroscopic measurement system according to the modified example 2-1.
  • the aqueous humor Raman spectroscopic measuring device 20A includes a collimating lens 32A.
  • the position of the notch filter 25 may be a portion where the light between the half mirror 23 and the optical fiber coupler 27 is substantially parallel.
  • the light transmitted through the half mirror 23 is measured by the spectroscope 29, but the light reflected by the half mirror 23 may be measured by the spectroscope 29.
  • the excitation light may be incident on the incident side light guide window 2 from a direction substantially orthogonal to the central axis A1, and the light guided to the outside of the contact lens 1 by the exit side light guide window 3 may be measured.
  • the substance contained in the aqueous humor 12 may be analyzed by infrared spectroscopy.

Abstract

This contact lens is provided with a concave inner surface that comes into contact with a subject's eye, and a convex outer surface, and is provided with an incidence-side light guiding window that is formed to be cut from the outer surface to the inner surface side, and guides light incident from a direction approximately orthogonal to a lens geometric center axis such that the light travels along the direction approximately orthogonal to the lens geometric center axis in the aqueous humor of the subject's eye wearing the contact lens. Consequently, provided is the contact lens that makes it possible to noninvasively analyze a substance contained in the aqueous humor of the subject's eye.

Description

コンタクトレンズ、房水ラマン分光計測装置、房水ラマン分光計測システム、及び房水ラマン分光計測方法Contact lens, aqueous humor Raman spectroscopic measurement device, aqueous humor Raman spectroscopic measurement system, and aqueous humor Raman spectroscopic measurement method
　本発明は、コンタクトレンズ、房水ラマン分光計測装置、房水ラマン分光計測システム、及び房水ラマン分光計測方法に関する。 The present invention relates to a contact lens, an aqueous humor Raman spectroscopic measurement device, an aqueous humor Raman spectroscopic measurement system, and an aqueous humor Raman spectroscopic measurement method.
　従来、被検眼における房水に含まれる物質を分析し、被検眼の診断に役立てる技術が知られている。この技術では、穿刺により角膜下の房水を抽出する必要があり、被検査者の負担が大きかった。 Conventionally, a technique has been known that analyzes substances contained in aqueous humor in an eye to be inspected and is useful for diagnosing the eye to be inspected. In this technique, it is necessary to extract the aqueous humor under the cornea by puncture, which imposes a heavy burden on the subject.
　非特許文献１には、非侵襲で被検眼の検査を行う技術が開示されている。この技術では、非特許文献１のＦＩＧＵＲＥ３に記載されているように、被検眼の鼻側あるいは耳側から光を横向きに入射させ、房水内を被検眼の眼軸（角膜の頂点と中心窩とを結ぶ線）の方向と略直交する方向に沿って透過させる。その結果、光は、被検眼の前方角膜と房水と後方角膜とをこの順に透過することでノイズ源となる透過組織の数を減らし、房水代謝産物の濃度計測を実施することが提案されている。また、その結果として、光が瞳孔を通過し眼球内部に進入して網膜に損傷を与えることを防止している。 Non-Patent Document 1 discloses a technique for non-invasively inspecting an eye to be inspected. In this technique, as described in FIGURE 3 of Non-Patent Document 1, light is incidented laterally from the nasal side or the ear side of the eye to be inspected, and the inside of the aqueous humor is the axis of the eye to be inspected (the apex of the cornea and the fovea centralis). It is transmitted along a direction that is substantially orthogonal to the direction of the line). As a result, it has been proposed that light transmits through the anterior cornea, aqueous humor, and posterior cornea of the eye to be inspected in this order to reduce the number of transmitting tissues that become noise sources and measure the concentration of aqueous humor metabolites. ing. As a result, it prevents light from passing through the pupil and entering the inside of the eyeball to damage the retina.
　しかしながら、本発明者らの角膜輪部における形状の解剖学的研究結果及び導入する光束の広がりや眼球運動に関するデータを基礎とした試算によると、多くの被検者の眼において、非特許文献１が示す光路を実現するには、被検眼に対する光の入射角を１°より小さい誤差で制御する必要があり、実現することが困難であると考えられる。 However, according to a trial calculation based on the anatomical study results of the shape of the corneal ring portion of the present inventors and the data on the spread of the luminous flux to be introduced and the eye movement, in the eyes of many subjects, Non-Patent Document 1 In order to realize the optical path shown by, it is necessary to control the incident angle of light with respect to the eye to be inspected with an error smaller than 1 °, which is considered to be difficult to realize.
　本発明は、上記に鑑みてなされたものであって、非侵襲で被検眼の房水に含まれる物質を分析することを可能とするコンタクトレンズ、房水ラマン分光計測装置、房水ラマン分光計測システム、及び房水ラマン分光計測方法を提供するものである。 The present invention has been made in view of the above, and is a contact lens, an aqueous humor Raman spectrophotometer, and an aqueous humor Raman spectrophotometric measurement capable of non-invasively analyzing substances contained in the aqueous humor of an eye to be inspected. It provides a system and an aqueous humor Raman spectrometric measurement method.
　上述した課題を解決し、目的を達成するために、本発明にかかるコンタクトレンズは、被検眼に接する凹型の内面と、凸型の外面とを備えるコンタクトレンズであって、前記外面から前記内面側に切り欠かれて形成されており、レンズ幾何中心軸と略直交する方向から入射した光が、当該コンタクトレンズを装用した前記被検眼の房水内において、前記レンズ幾何中心軸と略直交する方向に沿って進むように導光する入射側導光窓を備えることを特徴とする。 In order to solve the above-mentioned problems and achieve the object, the contact lens according to the present invention is a contact lens having a concave inner surface in contact with an eye to be inspected and a convex outer surface, and the contact lens is provided from the outer surface to the inner surface side. The direction in which light incident from a direction substantially orthogonal to the lens geometric center axis is formed so as to be substantially orthogonal to the lens geometric center axis in the aqueous humor of the eye to be inspected wearing the contact lens. It is characterized by providing an incident side light guide window that guides the light so as to proceed along the line.
　また、本発明にかかるコンタクトレンズは、上記発明において、前記入射側導光窓は、前記レンズ幾何中心軸とのなす角が８°以上２８°以下であることを特徴とする。 Further, the contact lens according to the present invention is characterized in that, in the above invention, the incident side light guide window has an angle formed by the lens geometric center axis of 8 ° or more and 28 ° or less.
　また、本発明にかかるコンタクトレンズは、上記発明において、当該コンタクトレンズの屈折率は、１．３６以上１．４６以下であることを特徴とする。 Further, the contact lens according to the present invention is characterized in that, in the above invention, the refractive index of the contact lens is 1.36 or more and 1.46 or less.
　また、本発明にかかるコンタクトレンズは、上記発明において、前記レンズ幾何中心軸を対称軸として、前記入射側導光窓と線対称の位置に形成されている出射側導光窓であって、前記外面から前記内面側に切り欠かれて形成されており、当該コンタクトレンズを装用した前記被検眼の前記房水を透過した光を当該コンタクトレンズの外部に導光する出射側導光窓を備えることを特徴とする。 Further, the contact lens according to the present invention is the exit side light guide window formed at a position line-symmetrical with the incident side light guide window with the lens geometric center axis as the axis of symmetry in the above invention. It is provided with a light emitting side light guide window which is formed by being cut out from the outer surface to the inner surface side and guides the light transmitted through the bunch of water of the eye to be inspected wearing the contact lens to the outside of the contact lens. It is characterized by.
　また、本発明にかかるコンタクトレンズは、上記発明において、前記入射側導光窓の周囲に配置されており、光を遮光する遮光部を備えることを特徴とする。 Further, the contact lens according to the present invention is characterized in that, in the above invention, it is arranged around the incident side light guide window and includes a light shielding portion that blocks light.
　また、本発明にかかるコンタクトレンズは、上記発明において、当該コンタクトレンズの中央部に貫通孔が形成されていることを特徴とする。 Further, the contact lens according to the present invention is characterized in that, in the above invention, a through hole is formed in the central portion of the contact lens.
　また、本発明にかかる房水ラマン分光計測装置は、励起光を出射する第１光源部と、前記励起光の光軸と略直交する方向に配置されているハーフミラーと、前記ハーフミラーを透過した前記励起光の被検眼の房水に含まれている物質による散乱光又は前記ハーフミラーで反射した前記散乱光の一方の光路上に配置されており、前記散乱光に含まれるレイリー散乱光と同じ波長の光を遮光し、前記散乱光に含まれるラマン散乱光を透過するフィルタと、前記フィルタを透過した光を分光計測する分光器と、前記ハーフミラーを透過した前記散乱光又は前記ハーフミラーで反射した前記散乱光の他方の光路上に配置されており、光を出射して前記被検眼を固視させるための第２光源部と、を備えることを特徴とする。 Further, the aqueous Raman spectroscopic measuring apparatus according to the present invention transmits the first light source unit that emits excitation light, a half mirror arranged in a direction substantially orthogonal to the optical axis of the excitation light, and the half mirror. The excitation light is arranged on one of the light paths of the scattered light due to the substance contained in the aqueous humor of the eye to be inspected or the scattered light reflected by the half mirror, and the Rayleigh scattered light contained in the scattered light. A filter that blocks light of the same wavelength and transmits Raman scattered light contained in the scattered light, a spectroscope that spectroscopically measures the light transmitted through the filter, and the scattered light or the half mirror transmitted through the half mirror. It is characterized in that it is arranged on the other optical path of the scattered light reflected by the above, and includes a second light source unit for emitting light to fix the eye to be inspected.
　また、本発明にかかる房水ラマン分光計測装置は、上記発明において、前記第２光源部は、前記フィルタに遮光される波長の光を出射することを特徴とする。 Further, the aqueous humor Raman spectroscopic measuring apparatus according to the present invention is characterized in that, in the above invention, the second light source unit emits light having a wavelength shaded by the filter.
　また、本発明にかかる房水ラマン分光計測装置は、上記発明において、前記第２光源部は、白色光を出射することを特徴とする。 Further, the aqueous humor Raman spectroscopic measuring apparatus according to the present invention is characterized in that, in the above invention, the second light source unit emits white light.
　また、本発明にかかる房水ラマン分光計測装置は、上記発明において、前記被検眼と前記ハーフミラーとの間において、前記第２光源部が出射する光の光軸は、前記分光器に入射する光の光軸から略５°ずれていることを特徴とする。 Further, in the Abomizu Raman spectroscopic measurement apparatus according to the present invention, in the above invention, the optical axis of the light emitted by the second light source unit is incident on the spectroscope between the eye to be inspected and the half mirror. It is characterized by being deviated from the optical axis of light by approximately 5 °.
　また、本発明にかかる房水ラマン分光計測システムは、被検眼に接する凹型の内面と、凸型の外面とを備えるコンタクトレンズであって、前記外面から前記内面側に切り欠かれて形成されており、レンズ幾何中心軸と略直交する方向から入射した光が、当該コンタクトレンズを装用した前記被検眼の房水内において、前記レンズ幾何中心軸と略直交する方向に沿って進むように導光する入射側導光窓を有するコンタクトレンズと、前記入射側導光窓に対して前記レンズ幾何中心軸と略直交する方向から入射するように励起光を出射する第１光源部と、前記励起光の光軸と略直交する方向に配置されているハーフミラーと、前記ハーフミラーを透過した前記励起光の前記被検眼の前記房水に含まれている物質による散乱光又は前記ハーフミラーで反射した前記散乱光の一方の光路上に配置されており、前記散乱光に含まれるレイリー散乱光と同じ波長の光を遮光し、前記散乱光に含まれるラマン散乱光を透過するフィルタと、前記フィルタを透過した光を分光計測する分光器と、前記ハーフミラーを透過した前記散乱光又は前記ハーフミラーで反射した前記散乱光の他方の光路上に配置されており、光を出射して前記被検眼を固視させるための第２光源部と、を備えることを特徴とする。 Further, the aqueous Raman spectroscopic measurement system according to the present invention is a contact lens having a concave inner surface in contact with an eye to be inspected and a convex outer surface, and is formed by being cut out from the outer surface to the inner surface side. Light that is incident from a direction substantially orthogonal to the geometric center axis of the lens travels along a direction substantially orthogonal to the geometric center axis of the lens in the aqueous humor of the eye to be inspected wearing the contact lens. A contact lens having an incident side light guide window, a first light source unit that emits excitation light so as to be incident on the incident side light guide window from a direction substantially orthogonal to the lens geometric center axis, and the excitation light. The half mirror is arranged in a direction substantially orthogonal to the optical axis of the above, and the excitation light transmitted through the half mirror is reflected by the scattered light by the substance contained in the aqueous chamber of the eye to be inspected or the half mirror. A filter that is arranged on one of the scattered light paths, blocks light having the same wavelength as Rayleigh scattered light contained in the scattered light, and transmits Raman scattered light contained in the scattered light, and the filter. The spectroscope that spectroscopically measures the transmitted light and the scattered light transmitted through the half mirror or the scattered light reflected by the half mirror are arranged on the other optical path, and emit light to emit the light to the eye to be inspected. It is characterized by including a second light source unit for fixing the image.
　また、本発明にかかる房水ラマン分光計測方法は、被検眼に接する凹型の内面と、凸型の外面とを備えるコンタクトレンズであって、前記外面から前記内面側に切り欠かれて形成されており、レンズ幾何中心軸と略直交する方向から入射した光が、当該コンタクトレンズを装用した前記被検眼の房水内において、前記レンズ幾何中心軸と略直交する方向に沿って進むように導光する入射側導光窓を有するコンタクトレンズを装用した前記被検眼の前記房水に含まれている物質によるラマン散乱光を計測する房水ラマン分光計測方法であって、第１光源部から出射した励起光が前記入射側導光窓に対して前記レンズ幾何中心軸と略直交する方向から入射するように位置合わせを行う位置合わせステップと、第２光源部から前記被検眼に光を出射して前記被検眼を固視させる固視ステップと、前記第１光源部から前記励起光を出射し、前記励起光の前記被検眼の前記房水に含まれている物質による散乱光に含まれるレイリー散乱光と同じ波長の光を遮光し、前記散乱光に含まれるラマン散乱光を透過するフィルタを透過した光を分光器により分光計測する計測ステップと、を含むことを特徴とする。 Further, the aqueous Raman spectroscopic measurement method according to the present invention is a contact lens having a concave inner surface in contact with an eye to be inspected and a convex outer surface, and is formed by being cut out from the outer surface to the inner surface side. Light that is incident from a direction substantially orthogonal to the geometric center axis of the lens travels along a direction substantially orthogonal to the geometric center axis of the lens in the aqueous humor of the eye to be inspected wearing the contact lens. A bunch of water Raman spectroscopic measurement method for measuring Raman scattered light by a substance contained in the bunch of water of the eye to be inspected wearing a contact lens having a light guide window on the incident side, which is emitted from a first light source unit. A positioning step in which the excitation light is aligned so as to enter the incident side light guide window from a direction substantially orthogonal to the lens geometric center axis, and light is emitted from the second light source unit to the eye to be inspected. Rayleigh scattering of the excitation light emitted from the first light source unit and the fixation step of fixing the eye to be inspected, and the scattered light of the excitation light by a substance contained in the aqueous humor of the eye to be inspected. It is characterized by including a measurement step of blocking light having the same wavelength as light and spectroscopically measuring the light transmitted through a filter that transmits the Raman scattered light contained in the scattered light with a spectroscope.
　また、本発明にかかる房水ラマン分光計測方法は、上記発明において、前記コンタクトレンズは、前記レンズ幾何中心軸を対称軸として、前記入射側導光窓と線対称の位置に形成されている出射側導光窓であって、前記外面から前記内面側に切り欠かれて形成されており、当該コンタクトレンズを装用した前記被検眼の前記房水を透過した光を当該コンタクトレンズの外部に導光する出射側導光窓を有し、前記計測ステップの前に、前記第１光源部から前記励起光より光強度が小さい透過検査光を出射し、前記入射側導光窓に入射した前記透過検査光が前記出射側導光窓から出射するか否かを検査する透過検査ステップを含むことを特徴とする。 Further, in the aqueous Raman spectroscopic measurement method according to the present invention, in the above invention, the contact lens is formed at a position line-symmetrical with the light guide window on the incident side with the geometric center axis of the lens as the axis of symmetry. A side light guide window, which is formed by being cut out from the outer surface to the inner surface side, and guides light transmitted through the aqueous humor of the eye to be inspected wearing the contact lens to the outside of the contact lens. The transmission inspection light having a light guide window on the exit side and having a transmission inspection light having a light intensity smaller than that of the excitation light is emitted from the first light source unit before the measurement step, and the transmission inspection is incident on the light guide window on the incident side. It is characterized by including a transmission inspection step for inspecting whether or not light is emitted from the light emitting side light guide window.
　本発明によれば、非侵襲で被検眼の房水に含まれる物質を分析することを可能とするコンタクトレンズ、房水ラマン分光計測装置、房水ラマン分光計測システム、及び房水ラマン分光計測方法を実現することができる。 According to the present invention, a contact lens, an aqueous humor Raman spectrometric apparatus, an aqueous humor Raman spectrometric measurement system, and an aqueous humor Raman spectrometric measurement method capable of non-invasively analyzing substances contained in the aqueous humor of an eye to be inspected. Can be realized.
図１は、本発明の実施の形態にかかる房水ラマン分光計測システムの模式図である。FIG. 1 is a schematic diagram of an aqueous humor Raman spectroscopic measurement system according to an embodiment of the present invention. 図２は、本発明の実施の形態にかかるコンタクトレンズを示す断面図である。FIG. 2 is a cross-sectional view showing a contact lens according to an embodiment of the present invention. 図３は、図２のＢ１矢視図である。FIG. 3 is a view taken along the line B1 of FIG. 図４は、被検眼に装用されたコンタクトレンズの模式図である。FIG. 4 is a schematic view of a contact lens worn on the eye to be inspected. 図５は、シミュレーションに用いた物性値を表す図である。FIG. 5 is a diagram showing physical property values used in the simulation. 図６は、界面における屈折の様子を表す図である。FIG. 6 is a diagram showing the state of refraction at the interface. 図７は、入射側導光窓及び出射側導光窓の傾斜角を変化させた場合の光の光路を表す図である。FIG. 7 is a diagram showing an optical path of light when the inclination angles of the light guide window on the incident side and the light guide window on the exit side are changed. 図８は、入射側導光窓及び出射側導光窓の傾斜角を変化させた場合の光の光路を表す図である。FIG. 8 is a diagram showing an optical path of light when the inclination angles of the light guide window on the incident side and the light guide window on the exit side are changed. 図９は、入射側導光窓及び出射側導光窓の傾斜角を変化させた場合の光の光路を表す図である。FIG. 9 is a diagram showing an optical path of light when the inclination angles of the light guide window on the incident side and the light guide window on the exit side are changed. 図１０は、入射側導光窓及び出射側導光窓の位置を変化させた場合の光の光路を表す図である。FIG. 10 is a diagram showing an optical path of light when the positions of the light guide window on the incident side and the light guide window on the exit side are changed. 図１１は、コンタクトレンズの屈折率を変化させた場合の光の光路を表す図である。FIG. 11 is a diagram showing an optical path of light when the refractive index of a contact lens is changed. 図１２は、コンタクトレンズの屈折率を変化させた場合の光の光路を表す図である。FIG. 12 is a diagram showing an optical path of light when the refractive index of a contact lens is changed. 図１３は、コンタクトレンズへの入射角度を変化させた場合の光の光路を表す図である。FIG. 13 is a diagram showing an optical path of light when the angle of incidence on the contact lens is changed. 図１４は、コンタクトレンズへの入射角度を変化させた場合の光の光路を表す図である。FIG. 14 is a diagram showing an optical path of light when the angle of incidence on a contact lens is changed. 図１５は、変形例１－１にかかるコンタクトレンズを示す断面図である。FIG. 15 is a cross-sectional view showing the contact lens according to the modified example 1-1. 図１６は、図１５のＢ２矢視図である。FIG. 16 is a view taken along the line B2 of FIG. 図１７は、変形例１－２にかかるコンタクトレンズを示す断面図である。FIG. 17 is a cross-sectional view showing the contact lens according to the modified example 1-2. 図１８は、図１７のＢ３矢視図である。FIG. 18 is a view taken along the line B3 of FIG. 図１９は、変形例１－３にかかるコンタクトレンズを示す断面図である。FIG. 19 is a cross-sectional view showing the contact lens according to the modified example 1-3. 図２０は、図１９のＢ４矢視図である。FIG. 20 is a view taken along the line B4 of FIG. 図２１は、変形例１－４にかかるコンタクトレンズを示す断面図である。FIG. 21 is a cross-sectional view showing the contact lens according to the modified example 1-4. 図２２は、図２１のＢ５矢視図である。FIG. 22 is a view taken along the line B5 of FIG. 21. 図２３は、変形例１－５にかかるコンタクトレンズを示す断面図である。FIG. 23 is a cross-sectional view showing the contact lens according to the modified example 1-5. 図２４は、図２３のＢ６矢視図である。FIG. 24 is a view taken along the line B6 of FIG. 23. 図２５は、変形例１－６にかかるコンタクトレンズを示す断面図である。FIG. 25 is a cross-sectional view showing the contact lens according to the modified example 1-6. 図２６は、図２５のＢ７矢視図である。FIG. 26 is a view taken along the line B7 of FIG. 25. 図２７は、変形例１－７にかかるコンタクトレンズを示す断面図である。FIG. 27 is a cross-sectional view showing the contact lens according to the modified example 1-7. 図２８は、図２７のＢ８矢視図である。FIG. 28 is a view taken along the line B8 of FIG. 27. 図２９は、変形例１－８にかかるコンタクトレンズを示す断面図である。FIG. 29 is a cross-sectional view showing the contact lens according to the modified example 1-8. 図３０は、図２９のＢ９矢視図である。FIG. 30 is a view taken along the line B9 of FIG. 29. 図３１は、変形例２－１にかかる房水ラマン分光計測システムの模式図である。FIG. 31 is a schematic diagram of the aqueous humor Raman spectroscopic measurement system according to the modified example 2-1.
　以下、本発明のコンタクトレンズ、房水ラマン分光計測装置、房水ラマン分光計測システム、及び房水ラマン分光計測方法の詳細について実施の形態に即して説明するが、これらは本発明を限定するものではない。 Hereinafter, the details of the contact lens, the aqueous humor Raman spectroscopic measurement device, the aqueous humor Raman spectroscopic measurement system, and the aqueous humor Raman spectroscopic measurement method of the present invention will be described in accordance with the embodiments, but these limit the present invention. It's not a thing.
（実施の形態）
〔房水ラマン分光計測システムの構成〕
　図１は、本発明の実施の形態にかかる房水ラマン分光計測システムの模式図である。房水ラマン分光計測システム１００は、被検眼１０の角膜１１の内側にある房水１２に含まれる物質をラマン分光法により分析するための計測を行う。房水ラマン分光計測システム１００は、図１に示すように、被検眼１０に装用されるコンタクトレンズ１と、コンタクトレンズ１に励起光を照射するとともに、被検眼１０の房水１２からのラマン散乱光を分光計測する房水ラマン分光計測装置２０と、を備える。 (Embodiment)
[Aqueous humor Raman spectroscopic measurement system configuration]
FIG. 1 is a schematic diagram of an aqueous humor Raman spectroscopic measurement system according to an embodiment of the present invention. The aqueous humor Raman spectroscopic measurement system 100 performs measurement for analyzing a substance contained in the aqueous humor 12 inside the cornea 11 of the eye 10 to be examined by Raman spectroscopy. As shown in FIG. 1, the Raman spectroscopic measurement system 100 irradiates the contact lens 1 worn on the eye 10 to be inspected and the contact lens 1 with excitation light, and Raman scattering from the tuft 12 of the eye 10 to be inspected. A bunch of Raman spectroscopic measurement device 20 for spectroscopically measuring light is provided.
〔コンタクトレンズの構成〕
　図２は、本発明の実施の形態にかかるコンタクトレンズを示す断面図である。図３は、図２のＢ１矢視図である。図２は、図３のＣ１－Ｃ１線に対応する断面図である。 [Construction of contact lenses]
FIG. 2 is a cross-sectional view showing a contact lens according to an embodiment of the present invention. FIG. 3 is a view taken along the line B1 of FIG. FIG. 2 is a cross-sectional view corresponding to line C1-C1 of FIG.
　コンタクトレンズ１は、図２に示すように、被検眼１０に接する凹型の内面１ａと、凸型の外面１ｂと、を備える。また、コンタクトレンズ１は、入射側導光窓２と、出射側導光窓３と、縁部４と、を備える。 As shown in FIG. 2, the contact lens 1 includes a concave inner surface 1a in contact with the eye 10 to be inspected and a convex outer surface 1b. Further, the contact lens 1 includes an incident side light guide window 2, an exit side light guide window 3, and an edge portion 4.
　コンタクトレンズ１は、例えばｐＨＥＭＡ（ポリヒドロキシエチルメタクリレート）からなるソフトコンタクトレンズであり、屈折率は１．４０６である。また、コンタクトレンズ１は、ＳＨＧ（シリコーンハイドロゲル）からなるソフトコンタクトレンズであってもよく、この場合、屈折率は１．３８５である。ただし、コンタクトレンズ１は、ハードコンタクトレンズであってもよい。 The contact lens 1 is a soft contact lens made of, for example, pHEMA (polyhydroxyethyl methacrylate) and has a refractive index of 1.406. Further, the contact lens 1 may be a soft contact lens made of SHG (silicone hydrogel), and in this case, the refractive index is 1.385. However, the contact lens 1 may be a hard contact lens.
　また、コンタクトレンズ１は、トーリックコンタクトレンズであることが好ましい。コンタクトレンズ１がトーリックコンタクトレンズである場合、瞬きによって入射側導光窓２が被検査者の耳側に、出射側導光窓３が被検査者の鼻側にそれぞれ位置するようにコンタクトレンズ１が回転する。 Further, the contact lens 1 is preferably a toric contact lens. When the contact lens 1 is a toric contact lens, the contact lens 1 is such that the light guide window 2 on the incident side is located on the ear side of the subject and the light guide window 3 on the exit side is located on the nose side of the subject by blinking. Rotates.
　入射側導光窓２は、外面１ｂから内面１ａ側に切り欠かれて形成されており、レンズ幾何中心軸（以下、「中心軸Ａ１」という）と略直交する方向から入射した光が、当該コンタクトレンズ１を装用した被検眼１０の房水１２内において、中心軸Ａ１と略直交する方向に沿って進むように導光する。入射側導光窓２により房水１２内において光が中心軸Ａ１と略直交する方向に沿って進むと、光が被検眼１０の内部に進入し、被検眼１０に損傷を与えることを防止することができる。 The light guide window 2 on the incident side is formed by being cut out from the outer surface 1b to the inner surface 1a side, and the light incident from a direction substantially orthogonal to the lens geometric central axis (hereinafter, referred to as “central axis A1”) is the said. In the aqueous humor 12 of the eye 10 to be inspected wearing the contact lens 1, the light is guided so as to proceed in a direction substantially orthogonal to the central axis A1. When the light travels in the aqueous humor 12 in the aqueous humor 12 in a direction substantially orthogonal to the central axis A1 by the incident side light guide window 2, the light enters the inside of the eye 10 to be inspected and prevents the eye 10 to be injured. be able to.
　出射側導光窓３は、中心軸Ａ１を対称軸として、入射側導光窓２と線対称の位置に形成されている。また、出射側導光窓３は、外面１ｂから内面１ａ側に切欠かれて形成されており、当該コンタクトレンズ１を装用した被検眼１０の房水１２を透過した光をコンタクトレンズ１の外部に導光する。出射側導光窓３により房水１２を透過した光がコンタクトレンズ１の外部に導光されることにより、より確実に光が被検眼１０に損傷を与えることを防止することができる。 The exit side light guide window 3 is formed at a position line-symmetrical with the incident side light guide window 2 with the central axis A1 as the axis of symmetry. Further, the light emitting side light guide window 3 is formed by being cut out from the outer surface 1b to the inner surface 1a side, and the light transmitted through the aqueous humor 12 of the eye 10 to be inspected wearing the contact lens 1 is transmitted to the outside of the contact lens 1. Guide light. By guiding the light transmitted through the aqueous humor 12 to the outside of the contact lens 1 by the light emitting window 3, it is possible to more reliably prevent the light from damaging the eye 10 to be inspected.
　縁部４は、入射側導光窓２及び出射側導光窓３に付随して形成される厚さが薄い部分である。 The edge portion 4 is a thin portion formed incidentally to the incident side light guide window 2 and the exit side light guide window 3.
〔コンタクトレンズに入射した光の光路のシミュレーション〕
　次に、被検眼１０に装用されたコンタクトレンズ１に入射した光の光路をシミュレーションする。図４は、被検眼に装用されたコンタクトレンズの模式図である。図４に示すように、中心軸Ａ１に直交する横軸をｘ、中心軸Ａ１に沿った縦軸をｙとし、入射側導光窓２及び出射側導光窓３と中心軸Ａ１とのなす角をγとした。入射側導光窓２及び出射側導光窓３の位置は、入射側導光窓２及び出射側導光窓３の端部までの半径ｒｃが５．６５ｍｍとなるように設定した。半径ｒｃの値は、男性の角膜半径の平均値が５．５ｍｍであることに基づいて、入射側導光窓２から入射した光が角膜に入射するように設定した。 [Simulation of the optical path of light incident on a contact lens]
Next, the optical path of the light incident on the contact lens 1 worn on the eye 10 to be inspected is simulated. FIG. 4 is a schematic view of a contact lens worn on the eye to be inspected. As shown in FIG. 4, the horizontal axis orthogonal to the central axis A1 is x, the vertical axis along the central axis A1 is y, and the incident side light guide window 2 and the exit side light guide window 3 are formed by the central axis A1. The angle was γ. Position of the incident-side light guide window 2 and the exit-side light guide window 3, the radius r c to the end of the entrance-side light guide window 2 and the exit side guide window 3 was set to be 5.65 mm. The value of the radius r c, based on the average value of the cornea radius men is 5.5 mm, the light incident from the incident side light guide window 2 is set to be incident on the cornea.
　コンタクトレンズ１は、被検眼１０の角膜１１の表面に装用される。そして、角膜上皮１１ａ及び角膜内皮１１ｂを表す曲線は、それぞれ以下の式（１）により表すことができる。
Figure JPOXMLDOC01-appb-M000001
 The contact lens 1 is worn on the surface of the cornea 11 of the eye 10 to be inspected. The curves representing the corneal epithelium 11a and the corneal endothelium 11b can be represented by the following equations (1), respectively.
Figure JPOXMLDOC01-appb-M000001
　式（１）において、Ｒは曲率半径、ａはＲの逆数（ａ＝１／Ｒ）、Ｋはコーニック定数、Ａ、Ｂ、Ｃ、Ｄは係数である。ここで、Ａ、Ｂ、Ｃは微少量としてゼロに近似すると、以下の式（２）が導かれる。
Figure JPOXMLDOC01-appb-M000002
 In equation (1), R is the radius of curvature, a is the reciprocal of R (a = 1 / R), K is the cornic constant, and A, B, C, and D are coefficients. Here, if A, B, and C are approximated to zero with a very small amount, the following equation (2) is derived.
Figure JPOXMLDOC01-appb-M000002
　図５は、シミュレーションに用いた物性値を表す図である。図５に示すように、角膜上皮１１ａ、角膜内皮１１ｂ、外面１ｂの物性値を定めると、図４に示す図を描くことができる。なお、Ｄは、図４いおけるｙ切片である。また、図４の原点Ｏは、被検眼１０の内転や外転における回転中心である。 FIG. 5 is a diagram showing physical property values used in the simulation. As shown in FIG. 5, if the physical property values of the corneal epithelium 11a, the corneal endothelium 11b, and the outer surface 1b are determined, the figure shown in FIG. 4 can be drawn. Note that D is the y-intercept in FIG. Further, the origin O in FIG. 4 is the center of rotation in the adduction or abduction of the eye 10 to be inspected.
　ここで、界面における光の屈折について説明する。図６は、界面における屈折の様子を表す図である。図６に示すように、屈折率ｎ１の媒質Ｉから屈折率ｎ２の媒質ＩＩへ光が入射する場合、入射光に対応するベクトルｉ１、界面の法線ベクトルＮ、法線ベクトルＮとベクトルｉ１とのなす角θを用いて、界面で屈折した光に対応するベクトルｉ２は、以下の式（３）に示すスネルの法則により表される。
Figure JPOXMLDOC01-appb-M000003
 Here, the refraction of light at the interface will be described. FIG. 6 is a diagram showing the state of refraction at the interface. As shown in FIG. 6, when light is incident on the medium II having a refractive index n 2 from the medium I having a refractive index n 1 , the vector i 1 corresponding to the incident light, the normal vector N at the interface, and the normal vector N The vector i 2 corresponding to the light refracted at the interface using the angle θ formed by the vector i 1 is expressed by Snell's law shown in the following equation (3).
Figure JPOXMLDOC01-appb-M000003
　図４に示すコンタクトレンズ１及び被検眼１０の各界面において、式（３）を適用することにより、被検眼１０に装用されたコンタクトレンズ１に入射した光の光路をシミュレーションすることができる。なお、以下のシミュレーションにおいて、空気の屈折率ｎａｉｒは１．００、コンタクトレンズ１の屈折率ｎｃは１．４０６、角膜の屈折率ｎｃｏｒは１．３７、房水の屈折率ｎａｈは１．３３とした。また、入射する光のビーム径は、４００μｍとした。 By applying the equation (3) at each interface between the contact lens 1 and the eye 10 shown in FIG. 4, it is possible to simulate the optical path of the light incident on the contact lens 1 worn on the eye 10. In the following simulation, the refractive index n air of air is 1.00, the refractive index n c of contact lens 1 is 1.406, the refractive index n cor of the cornea is 1.37, and the refractive index n ah of aqueous humor is 1. It was set to 1.33. The beam diameter of the incident light was 400 μm.
〔コンタクトレンズの入射側導光窓及び出射側導光窓の傾斜角〕
　次に、入射側導光窓２及び出射側導光窓３の傾斜角γを変化させた場合の光の光路をシミュレーションする。図７～図９は、入射側導光窓及び出射側導光窓の傾斜角を変化させた場合の光の光路を表す図である。図７～図９において、光は水平方向（入射角α＝０°）から入射するものとする。 [Inclination angle of the light guide window on the incident side and the light guide window on the exit side of the contact lens]
Next, the optical path of light when the inclination angle γ of the light guide window 2 on the incident side and the light guide window 3 on the exit side is changed is simulated. 7 to 9 are views showing an optical path of light when the inclination angles of the light guide window on the incident side and the light guide window on the exit side are changed. In FIGS. 7 to 9, it is assumed that the light is incident from the horizontal direction (incident angle α = 0 °).
　図７では、入射側導光窓２及び出射側導光窓３の傾斜角γが１５°である。この場合、入射側導光窓２から入射した光の光路が最も水平方向に沿った光路となる。 In FIG. 7, the inclination angle γ of the incident side light guide window 2 and the exit side light guide window 3 is 15 °. In this case, the optical path of the light incident from the incident side light guide window 2 is the optical path along the most horizontal direction.
　図８では、入射側導光窓２及び出射側導光窓３の傾斜角γが８°である。この場合、入射側導光窓２から入射した光は、出射側導光窓３からコンタクトレンズ１の外部に導光された。そして、入射側導光窓２及び出射側導光窓３の傾斜角γが８°より小さいと、入射側導光窓２から入射した光を、出射側導光窓３からコンタクトレンズ１の外部に導光することができない。 In FIG. 8, the inclination angle γ of the incident side light guide window 2 and the exit side light guide window 3 is 8 °. In this case, the light incident from the incident side light guide window 2 is guided to the outside of the contact lens 1 from the exit side light guide window 3. When the inclination angle γ of the incident side light guide window 2 and the exit side light guide window 3 is smaller than 8 °, the light incident from the incident side light guide window 2 is transmitted from the exit side light guide window 3 to the outside of the contact lens 1. Cannot guide light to.
　図９では、入射側導光窓２及び出射側導光窓３の傾斜角γが２８°である。この場合、入射側導光窓２から入射した光は、出射側導光窓３からコンタクトレンズ１の外部に導光された。そして、入射側導光窓２及び出射側導光窓３の傾斜角γが２８°より大きいと、入射側導光窓２から入射した光を、出射側導光窓３からコンタクトレンズ１の外部に導光することができない。 In FIG. 9, the inclination angle γ of the incident side light guide window 2 and the exit side light guide window 3 is 28 °. In this case, the light incident from the incident side light guide window 2 is guided to the outside of the contact lens 1 from the exit side light guide window 3. When the inclination angle γ of the incident side light guide window 2 and the exit side light guide window 3 is larger than 28 °, the light incident from the incident side light guide window 2 is transmitted from the exit side light guide window 3 to the outside of the contact lens 1. Cannot guide light to.
　以上説明したように、光を略水平方向から入射する場合、入射側導光窓２及び出射側導光窓３の傾斜角γが１５°であることが最も好ましく、傾斜角γが８°以上２８°以下であることが好ましい。この場合、入射側導光窓２から入射した光が出射側導光窓３から外部に導光されるので安全性が高い。 As described above, when light is incident from a substantially horizontal direction, the inclination angle γ of the incident side light guide window 2 and the exit side light guide window 3 is most preferably 15 °, and the inclination angle γ is 8 ° or more. It is preferably 28 ° or less. In this case, the light incident from the incident side light guide window 2 is guided to the outside from the exit side light guide window 3, so that the safety is high.
〔コンタクトレンズの入射側導光窓及び出射側導光窓の位置〕
　次に、入射側導光窓２及び出射側導光窓３の位置を変化させた場合の光の光路をシミュレーションする。図７において、入射側導光窓２及び出射側導光窓３の位置は、男性の角膜半径の平均値５．５ｍｍに応じて、半径ｒｃが５．６５ｍｍとなるように設定されている。しかしながら、角膜半径の大きさには個人差があるため、角膜半径が小さい人に対応するには、半径ｒｃを小さく設定する必要がある。 [Position of light guide window on the incident side and light guide window on the exit side of the contact lens]
Next, the optical path of light when the positions of the light guide window 2 on the incident side and the light guide window 3 on the exit side are changed is simulated. 7, the position of the incident-side light guide window 2 and the exit-side light guide window 3, in accordance with the average value 5.5mm corneal radius men, radius r c is set to be 5.65mm .. However, because of individual differences in the size of the cornea radius to correspond to the human cornea radius is small, it is necessary to set a small radius r c.
　図１０は、入射側導光窓及び出射側導光窓の位置を変化させた場合の光の光路を表す図である。図１０において、半径ｒｃは、４．６５ｍｍに設定した。また、入射側導光窓２及び出射側導光窓３の傾斜角γは１５°、光は水平方向（入射角α＝０°）から入射するものとする。この場合、入射側導光窓２及び出射側導光窓３の傾斜角γが２２°のとき、水平方向から入射側導光窓２に入射した光の光路が最も水平方向に沿った光路となる。 FIG. 10 is a diagram showing an optical path of light when the positions of the light guide window on the incident side and the light guide window on the exit side are changed. 10, the radius r c was set to 4.65 mm. Further, it is assumed that the inclination angle γ of the light guide window 2 on the incident side and the light guide window 3 on the exit side is 15 °, and the light is incident from the horizontal direction (incident angle α = 0 °). In this case, when the inclination angle γ of the incident side light guide window 2 and the exit side light guide window 3 is 22 °, the optical path of the light incident on the incident side light guide window 2 from the horizontal direction is the optical path along the most horizontal direction. Become.
　同様に、半径ｒｃを５．０５ｍｍに設定した場合、入射側導光窓２及び出射側導光窓３の傾斜角γが１８°のとき、水平方向から入射側導光窓２に入射した光の光路が最も水平方向に沿った光路となる。 Similarly, if you set the radius r c to 5.05 mm, when the inclination angle of the incident side light guide window 2 and the exit-side light guide window 3 gamma is 18 °, incident from the horizontal direction to the incident side light guide window 2 The optical path of light is the most horizontal optical path.
　以上説明したように、角膜半径の大きさに応じて、半径ｒｃを変化させることにより、入射側導光窓２から入射した光が出射側導光窓３から外部に導光されるので安全性が高い。このとき、半径ｒｃに応じて入射側導光窓２及び出射側導光窓３の傾斜角γを適切な値に設定することが好ましい。 Safety As described above, according to the size of the corneal radius, by varying the radius r c, the light incident from the incident side light guide window 2 is guided to the outside from the outgoing side light guide window 3 High sex. In this case, it is preferable to set the appropriate value γ inclination angle of the incident side light guide window 2 and the exit side light guide window 3 in accordance with the radius r c.
〔コンタクトレンズの屈折率〕
　次に、コンタクトレンズ１の屈折率を変化させた場合の光の光路をシミュレーションする。図１１、図１２は、コンタクトレンズの屈折率を変化させた場合の光の光路を表す図である。図１１、図１２において、入射側導光窓２及び出射側導光窓３の傾斜角γは１５°、光は水平方向（入射角α＝０°）から入射するものとする。 [Refractive index of contact lenses]
Next, the optical path of light when the refractive index of the contact lens 1 is changed is simulated. 11 and 12 are diagrams showing the optical path of light when the refractive index of the contact lens is changed. In FIGS. 11 and 12, it is assumed that the angle of inclination γ of the light guide window 2 on the incident side and the light guide window 3 on the exit side is 15 °, and the light is incident from the horizontal direction (incident angle α = 0 °).
　図１１では、コンタクトレンズ１の屈折率が１．３６である。この場合、入射側導光窓２から入射した光は、出射側導光窓３からコンタクトレンズ１の外部に導光された。そして、コンタクトレンズ１の屈折率が１．３６より小さいと、入射側導光窓２から入射した光を、出射側導光窓３からコンタクトレンズ１の外部に導光することができない。 In FIG. 11, the refractive index of the contact lens 1 is 1.36. In this case, the light incident from the incident side light guide window 2 is guided to the outside of the contact lens 1 from the exit side light guide window 3. If the refractive index of the contact lens 1 is smaller than 1.36, the light incident from the incident side light guide window 2 cannot be guided to the outside of the contact lens 1 from the exit side light guide window 3.
　図１２では、コンタクトレンズ１の屈折率が１．４６である。この場合、入射側導光窓２から入射した光は、出射側導光窓３からコンタクトレンズ１の外部に導光された。そして、コンタクトレンズ１の屈折率が１．４６より大きいと、入射側導光窓２から入射した光を、出射側導光窓３からコンタクトレンズ１の外部に導光することができない。 In FIG. 12, the refractive index of the contact lens 1 is 1.46. In this case, the light incident from the incident side light guide window 2 is guided to the outside of the contact lens 1 from the exit side light guide window 3. If the refractive index of the contact lens 1 is larger than 1.46, the light incident from the incident side light guide window 2 cannot be guided to the outside of the contact lens 1 from the exit side light guide window 3.
　以上説明したように、光を略水平方向から入射する場合、コンタクトレンズ１の屈折率が１．３６以上１．４６以下であることが好ましい。この場合、入射側導光窓２から入射した光が出射側導光窓３から外部に導光されるので安全性が高い。 As described above, when light is incident from a substantially horizontal direction, the refractive index of the contact lens 1 is preferably 1.36 or more and 1.46 or less. In this case, the light incident from the incident side light guide window 2 is guided to the outside from the exit side light guide window 3, so that the safety is high.
〔コンタクトレンズ１への光の入射角〕
　次に、コンタクトレンズ１に入射する光の入射角を変化させた場合の光の光路をシミュレーションする。コンタクトレンズ１に対して光を水平方向（入射角α＝０°）から入射することが好ましいが、実際には入射角αが水平方向からずれる場合があるため、光の入射角αのずれに対する許容量をシミュレーションにより算出する。 [Angle of light incident on contact lens 1]
Next, the optical path of the light when the incident angle of the light incident on the contact lens 1 is changed is simulated. It is preferable that the light is incident on the contact lens 1 from the horizontal direction (incident angle α = 0 °), but in reality, the incident angle α may deviate from the horizontal direction, so that the light is incident on the deviation of the incident angle α. Calculate the allowable amount by simulation.
　図１３、図１４は、コンタクトレンズへの入射角度を変化させた場合の光の光路を表す図である。 13 and 14 are diagrams showing the optical path of light when the angle of incidence on the contact lens is changed.
　図１３では、入射側導光窓２及び出射側導光窓３の傾斜角γが０°、光の入射角αが－５°である。なお、入射角αは、被検査者の耳側を正、被検査者の耳側と反対側を負とする。この場合、入射側導光窓２から入射した光は、出射側導光窓３からコンタクトレンズ１の外部に導光された。 In FIG. 13, the inclination angle γ of the incident side light guide window 2 and the exit side light guide window 3 is 0 °, and the incident angle α of light is −5 °. The incident angle α is positive on the ear side of the subject and negative on the side opposite to the ear side of the subject. In this case, the light incident from the incident side light guide window 2 is guided to the outside of the contact lens 1 from the exit side light guide window 3.
　図１４では、入射側導光窓２及び出射側導光窓３の傾斜角γが３０°、光の入射角αが４°である。この場合、入射側導光窓２から入射した光は、出射側導光窓３からコンタクトレンズ１の外部に導光された。 In FIG. 14, the angle of inclination γ of the light guide window 2 on the incident side and the light guide window 3 on the exit side is 30 °, and the incident angle α of light is 4 °. In this case, the light incident from the incident side light guide window 2 is guided to the outside of the contact lens 1 from the exit side light guide window 3.
　以上説明したように、入射側導光窓２及び出射側導光窓３の傾斜角γにも依存するが、光の入射角αが－４°以上５°以下であると、入射側導光窓２から入射した光が出射側導光窓３から外部に導光されるので安全性が高い。すなわち、コンタクトレンズ１に対する光の入射角αが水平方向からずれても、すれが小さければ安全性が保たれる。 As described above, although it depends on the inclination angle γ of the incident side light guide window 2 and the exit side light guide window 3, when the light incident angle α is -4 ° or more and 5 ° or less, the incident side light guide Since the light incident from the window 2 is guided to the outside through the light emitting side light guide window 3, the safety is high. That is, even if the incident angle α of the light with respect to the contact lens 1 deviates from the horizontal direction, safety is maintained as long as the light is small.
〔房水ラマン分光計測装置の構成〕
　房水ラマン分光計測装置２０は、図１に示すように、第１光源部２１と、遮光部材２２と、ハーフミラー２３と、対物レンズ２４と、ノッチフィルタ２５と、集光レンズ２６と、光ファイバ結合器２７と、光ファイバ２８と、分光器２９と、第２光源部３０と、カメラ３１と、を備える。 [Structure of aqueous humor Raman spectroscopic measurement device]
As shown in FIG. 1, the Fusamizu Raman spectrophotometer 20 includes a first light source unit 21, a light-shielding member 22, a half mirror 23, an objective lens 24, a notch filter 25, a condensing lens 26, and light. It includes a fiber coupler 27, an optical fiber 28, a spectroscope 29, a second light source unit 30, and a camera 31.
　房水ラマン分光計測装置２０は、第１光源部２１から出射する励起光Ｌ１と略直交する方向の光Ｌ３を計測する。これは、ラマン散乱光がどの方向で計測しても同じ光強度であるのに対して、レイリー散乱光が励起光と略直交する方向において光強度が最も弱くなるため、ラマン散乱光を効率よく計測することができるためである。なお、被検眼１０の房水１２を透過し、出射側導光窓３によりコンタクトレンズ１の外部に導光された光Ｌ２の光路上に、この光を吸収する光吸収体を配置してもよい。 The aqueous humor Raman spectroscopic measurement device 20 measures the light L3 in a direction substantially orthogonal to the excitation light L1 emitted from the first light source unit 21. This is because the Raman scattered light has the same light intensity regardless of the direction measured, whereas the Rayleigh scattered light has the weakest light intensity in the direction substantially orthogonal to the excitation light, so that the Raman scattered light is efficiently used. This is because it can be measured. Even if a light absorber that absorbs this light is arranged on the optical path of the light L2 that has passed through the bunch of water 12 of the eye 10 to be inspected and is guided to the outside of the contact lens 1 by the light emitting side light guide window 3. Good.
　第１光源部２１は、被検眼１０の房水１２におけるラマン散乱光を分光計測するための励起光Ｌ１を出射する。また、第１光源部２１は、励起光Ｌ１より光強度が小さい透過検査光を出射する。透過検査光は、測定を行う前に入射側導光窓２に入射した透過検査光が出射側導光窓３から出射するか否かを検査するために用いられる。励起光Ｌ１及び透過検査光の波長は、例えば５３２ｎｍであるが、特に限定されない。透過検査光は、励起光と同じ波長であることが好ましい。第１光源部２１は、所定の波長の光を出射する光源であればよく、例えばＬＥＤ（Ｌｉｇｈｔ　Ｅｍｉｔｔｉｎｇ　Ｄｉｏｄｅ）である。 The first light source unit 21 emits excitation light L1 for spectroscopically measuring Raman scattered light in the aqueous humor 12 of the eye 10 to be inspected. Further, the first light source unit 21 emits transmission inspection light having a light intensity smaller than that of the excitation light L1. The transmission inspection light is used for inspecting whether or not the transmission inspection light incident on the incident side light guide window 2 is emitted from the exit side light guide window 3 before the measurement is performed. The wavelengths of the excitation light L1 and the transmission inspection light are, for example, 532 nm, but are not particularly limited. The transmission inspection light preferably has the same wavelength as the excitation light. The first light source unit 21 may be a light source that emits light having a predetermined wavelength, and is, for example, an LED (Light Emitting Diode).
　遮光部材２２は、ゴム等の弾性部材からなる。遮光部材２２は、被検眼１０の周囲を覆い、外光が房水ラマン分光計測装置２０の筐体内に入射しないよう遮光する。 The light-shielding member 22 is made of an elastic member such as rubber. The light-shielding member 22 covers the periphery of the eye 10 to be inspected and shields external light from entering the housing of the aqueous humor Raman spectroscopic measurement device 20.
　ハーフミラー２３は、励起光Ｌ１の光軸と略直交する方向に配置されている。ハーフミラー２３は、励起光Ｌ１の被検眼１０の房水１２に含まれている物質による散乱光Ｌ３の一部を透過するとともに、散乱光Ｌ３の一部を反射する。 The half mirror 23 is arranged in a direction substantially orthogonal to the optical axis of the excitation light L1. The half mirror 23 transmits a part of the scattered light L3 by the substance contained in the aqueous humor 12 of the eye 10 to be inspected for the excitation light L1 and reflects a part of the scattered light L3.
　対物レンズ２４は、散乱光Ｌ３を集光する。 The objective lens 24 collects scattered light L3.
　ノッチフィルタ２５は、本発明に係るフィルタに相当する。ノッチフィルタ２５は、ハーフミラー２３を透過した光Ｌ４の光路上に配置されており、散乱光Ｌ３に含まれているレイリー散乱光と同じ波長の光を選択的に遮光するバンドストップフィルタである。従って、ノッチフィルタ２５は、散乱光Ｌ３に含まれているレイリー散乱光を遮光し、ラマン散乱光を透過する。ただし、フィルタは、散乱光Ｌ３に含まれているレイリー散乱光と同じ波長の光を選択的に遮光し、散乱光Ｌ３に含まれているラマン散乱光を透過するフィルタであればよい。例えば、ストークスラマン散乱を計測する場合には、励起光Ｌ１より長波長側を透過するフィルタを用いてもよい。また、反ストークス散乱を計測する場合には、励起光Ｌ１より短波長側を透過するフィルタを用いてもよい。また、波長が既知のラマン散乱光を計測する場合には、ラマン散乱光を選択的に透過するバンドパスフィルタを用いてもよい。 The notch filter 25 corresponds to the filter according to the present invention. The notch filter 25 is a band-stop filter that is arranged on the optical path of the light L4 that has passed through the half mirror 23 and selectively blocks light having the same wavelength as the Rayleigh scattered light contained in the scattered light L3. Therefore, the notch filter 25 blocks the Rayleigh scattered light contained in the scattered light L3 and transmits the Raman scattered light. However, the filter may be a filter that selectively blocks light having the same wavelength as the Rayleigh scattered light contained in the scattered light L3 and transmits the Raman scattered light contained in the scattered light L3. For example, when measuring Stoke Raman scattering, a filter that transmits on the wavelength side longer than the excitation light L1 may be used. Further, when measuring anti-Stokes scattering, a filter that transmits on the wavelength side shorter than the excitation light L1 may be used. Further, when measuring Raman scattered light having a known wavelength, a bandpass filter that selectively transmits Raman scattered light may be used.
　集光レンズ２６は、ノッチフィルタ２５を透過した光Ｌ４を集光し、光ファイバ結合器２７に結合させる。 The condensing lens 26 condenses the light L4 that has passed through the notch filter 25 and couples it to the optical fiber coupler 27.
　光ファイバ結合器２７は、集光レンズ２６が集光した光Ｌ４を光ファイバ２８に導く。 The optical fiber coupler 27 guides the light L4 collected by the condensing lens 26 to the optical fiber 28.
　光ファイバ２８は、光ファイバ結合器２７に導かれた光を導光する。 The optical fiber 28 guides the light guided to the optical fiber coupler 27.
　分光器２９は、フィルタを透過した光を分光計測する。なお、集光レンズ２６により集光した光を直接分光器に入射させてもよい。この場合、光ファイバ結合器２７及び光ファイバ２８は、不要である。 The spectroscope 29 spectroscopically measures the light transmitted through the filter. The light collected by the condensing lens 26 may be directly incident on the spectroscope. In this case, the optical fiber coupler 27 and the optical fiber 28 are unnecessary.
　第２光源部３０は、ハーフミラー２３で反射した散乱光の光路上に配置されており、光を出射して被検眼１０を固視させる。すなわち、第２光源部は、被検眼１０を固視させる固視標として用いることができる。なお、被検眼１０とハーフミラー２３との間において、第２光源部３０が出射する光Ｅの光軸は、分光器２９に入射する光Ｌ３の光軸から略５°ずれている。これは、光Ｌ３と略一致する被検眼１０の眼軸（角膜１１の頂点と中心窩とを結ぶ線）に対して、光Ｅと略一致する視線（被検眼１０の注視点と中心窩とを結ぶ線）が５°内側（鼻側）にずれていることによる。第２光源部３０から出射する光の波長は、ノッチフィルタ２５に遮光される波長であり、例えば５３２ｎｍである。また、第２光源部３０は、白色光を出射可能であってもよい。この場合、カメラ３１により被検眼１０の状態を観察する際の照明として第２光源部３０を用いることができる。 The second light source unit 30 is arranged on the optical path of the scattered light reflected by the half mirror 23, and emits the light to fix the eye 10 to be inspected. That is, the second light source unit can be used as a fixation target for fixing the eye 10 to be inspected. The optical axis of the light E emitted by the second light source unit 30 between the eye 10 to be inspected and the half mirror 23 is deviated by approximately 5 ° from the optical axis of the light L3 incident on the spectroscope 29. This is the line of sight (the line of sight of the eye 10 to be inspected and the fovea centralis) that is substantially the same as the light E with respect to the axis of the eye 10 to be inspected (the line connecting the apex of the cornea 11 and the fovea centralis). This is because the line connecting the lights) is shifted inward (nose side) by 5 °. The wavelength of the light emitted from the second light source unit 30 is a wavelength shaded by the notch filter 25, for example, 532 nm. Further, the second light source unit 30 may be capable of emitting white light. In this case, the second light source unit 30 can be used as the illumination when observing the state of the eye 10 to be inspected by the camera 31.
　カメラ３１は、被検眼１０を撮像する。カメラ３１により被検眼１０を観察することにより、被検眼１０の結膜が充血しているか、睫毛が計測に影響を及ぼさないかなど、被検眼１０の状態を観察することができる。 The camera 31 captures the eye 10 to be inspected. By observing the eye 10 to be inspected with the camera 31, it is possible to observe the state of the eye 10 to be inspected, such as whether the conjunctiva of the eye to be inspected 10 is hyperemic or the eyelashes do not affect the measurement.
〔房水ラマン分光計測システムによる房水ラマン分光計測方法〕
　次に、房水ラマン分光計測システム１００による房水ラマン分光計測方法について説明する。まず、コンタクトレンズ１を被検眼１０に装用する。このとき、コンタクトレンズ１がトーリックコンタクトレンズであると、瞬きによって入射側導光窓２が被検査者の耳側に、出射側導光窓３が被検査者の鼻側にそれぞれ位置するようにコンタクトレンズ１が回転する。 [Aqueous humor Raman spectroscopic measurement method by aqueous humor Raman spectroscopic measurement system]
Next, the aqueous humor Raman spectroscopic measurement method by the aqueous humor Raman spectroscopic measurement system 100 will be described. First, the contact lens 1 is worn on the eye 10 to be inspected. At this time, if the contact lens 1 is a toric contact lens, the incident side light guide window 2 is located on the subject's ear side and the exit side light guide window 3 is located on the subject's nose side by blinking. The contact lens 1 rotates.
　続いて、第１光源部２１から出射した励起光が入射側導光窓２に対してレンズ幾何中心軸と略直交する方向から入射するように位置合わせを行う（位置合わせステップ）。具体的には、被検眼１０と房水ラマン分光計測装置２０との相対的な位置を調整することにより、被検眼１０の光軸と光Ｌ３の光路とを略一致させる。 Subsequently, the excitation light emitted from the first light source unit 21 is aligned so as to enter the incident side light guide window 2 from a direction substantially orthogonal to the lens geometric center axis (alignment step). Specifically, by adjusting the relative positions of the eye 10 to be inspected and the aqueous humor Raman spectroscopic measurement device 20, the optical axis of the eye 10 to be inspected and the optical path of the light L3 are substantially aligned.
　さらに、第２光源部３０から被検眼１０に光を出射して被検眼を固視させる（固視ステップ）。 Further, light is emitted from the second light source unit 30 to the eye 10 to be inspected to fix the eye to be inspected (fixation step).
　その後、第１光源部２１から透過検査光を出射し、入射側導光窓２に入射した透過検査光が出射側導光窓３から出射するか否かを検査する（透過検査ステップ）。 After that, the transmission inspection light is emitted from the first light source unit 21, and it is inspected whether or not the transmission inspection light incident on the incident side light guide window 2 is emitted from the exit side light guide window 3 (transmission inspection step).
　透過検査光が出射側導光窓３から出射することが確認されると、第１光源部２１から励起光を出射し、ノッチフィルタ２５を透過した光を分光器２９により分光計測する（計測ステップ）。 When it is confirmed that the transmission inspection light is emitted from the light guide window 3 on the exit side, the excitation light is emitted from the first light source unit 21, and the light transmitted through the notch filter 25 is spectrally measured by the spectroscope 29 (measurement step). ).
　そして、分光計測された光のスペクトルを分析することにより、被検眼１０の房水１２に含まれる物質を分析することができる。 Then, by analyzing the spectrum of the spectroscopically measured light, the substance contained in the aqueous humor 12 of the eye 10 to be inspected can be analyzed.
　以上説明した房水ラマン分光計測方法によれば、入射側導光窓２を備えるコンタクトレンズ１を用いることにより、非侵襲で被検眼１０の房水１２からのラマン散乱光を計測することができる。従って、実施の形態によれば、非侵襲で被検眼１０の房水１２に含まれる物質を分析することが可能となる。 According to the aqueous humor Raman spectroscopic measurement method described above, the Raman scattered light from the aqueous humor 12 of the eye 10 to be inspected can be measured non-invasively by using the contact lens 1 provided with the incident side light guide window 2. .. Therefore, according to the embodiment, it is possible to analyze the substance contained in the aqueous humor 12 of the eye 10 to be examined non-invasively.
　また、実施の形態によれば、励起光Ｌ１の光軸に対して入射側導光窓２及び出射側導光窓３が斜め交差するように形成されているため、入射側導光窓２及び出射側導光窓３における反射光が第１光源部２１に戻り、第１光源部２１の動作が不安定になることを防止することができる。これに対して、被検眼１０を生理食塩水等の液体で満たした容器で覆い、被検眼１０を液体に浸した状態で計測する方法では、容器に設けられた導光窓が励起光の光軸に直交するため、導光窓における反射光が第１光源部２１に戻り、第１光源部２１の動作が不安定になる場合がある。 Further, according to the embodiment, since the incident side light guide window 2 and the exit side light guide window 3 are formed so as to diagonally intersect the optical axis of the excitation light L1, the incident side light guide window 2 and It is possible to prevent the reflected light from the light emitting side light guide window 3 from returning to the first light source unit 21 and making the operation of the first light source unit 21 unstable. On the other hand, in the method in which the eye 10 to be inspected is covered with a container filled with a liquid such as physiological saline and the eye 10 to be inspected is immersed in the liquid for measurement, the light guide window provided in the container is the light of the excitation light. Since it is orthogonal to the axis, the reflected light in the light guide window returns to the first light source unit 21, and the operation of the first light source unit 21 may become unstable.
〔コンタクトレンズの変形例〕
（変形例１－１）
　図１５は、変形例１－１にかかるコンタクトレンズを示す断面図である。図１６は、図１５のＢ２矢視図である。図１５は、図１６のＣ２－Ｃ２線に対応する断面図である。軸Ａ２は、コンタクトレンズ１Ａのレンズ幾何中心軸である。 [Modification of contact lenses]
(Modification 1-1)
FIG. 15 is a cross-sectional view showing the contact lens according to the modified example 1-1. FIG. 16 is a view taken along the line B2 of FIG. FIG. 15 is a cross-sectional view corresponding to line C2-C2 of FIG. The axis A2 is the lens geometric center axis of the contact lens 1A.
　図１５、図１６に示すように、コンタクトレンズ１Ａは、入射側導光窓２を有し、出射側導光窓を有しない。このように、コンタクトレンズは、出射側導光窓を有していなくてもよい。 As shown in FIGS. 15 and 16, the contact lens 1A has an incident side light guide window 2 and does not have an exit side light guide window. As described above, the contact lens does not have to have a light guide window on the exit side.
（変形例１－２）
　図１７は、変形例１－２にかかるコンタクトレンズを示す断面図である。図１８は、図１７のＢ３矢視図である。図１７は、図１８のＣ３－Ｃ３線に対応する断面図である。軸Ａ３は、コンタクトレンズ１Ｂのレンズ幾何中心軸である。 (Modification 1-2)
FIG. 17 is a cross-sectional view showing the contact lens according to the modified example 1-2. FIG. 18 is a view taken along the line B3 of FIG. FIG. 17 is a cross-sectional view corresponding to line C3-C3 of FIG. The axis A3 is the lens geometric center axis of the contact lens 1B.
　図１７、図１８に示すように、コンタクトレンズ１Ｂは、円環状に一連の導光窓２Ｂ及び縁部４Ｂを備える。導光窓２Ｂは、入射側の導光窓と、出射側の導光窓とを兼ねる。この場合、被検眼１０においてコンタクトレンズ１Ｂが回転しても構わないため、コンタクトレンズ１Ｂは、トーリックコンタクトレンズでなくてよい。 As shown in FIGS. 17 and 18, the contact lens 1B includes a series of light guide windows 2B and an edge 4B in an annular shape. The light guide window 2B also serves as a light guide window on the incident side and a light guide window on the exit side. In this case, the contact lens 1B does not have to be a toric contact lens because the contact lens 1B may rotate in the eye 10 to be inspected.
（変形例１－３）
　図１９は、変形例１－３にかかるコンタクトレンズを示す断面図である。図２０は、図１９のＢ４矢視図である。図１９は、図２０のＣ４－Ｃ４線に対応する断面図である。軸Ａ４は、コンタクトレンズ１Ｃのレンズ幾何中心軸である。 (Modification 1-3)
FIG. 19 is a cross-sectional view showing the contact lens according to the modified example 1-3. FIG. 20 is a view taken along the line B4 of FIG. FIG. 19 is a cross-sectional view corresponding to line C4-C4 of FIG. The axis A4 is the lens geometric center axis of the contact lens 1C.
　図１９、図２０に示すように、コンタクトレンズ１Ｃは、半円状の入射側導光窓２Ｃ及び縁部４Ｃを備える。このように、コンタクトレンズは、出射側導光窓を有していなくてもよい。 As shown in FIGS. 19 and 20, the contact lens 1C includes a semicircular incident side light guide window 2C and an edge portion 4C. As described above, the contact lens does not have to have a light guide window on the exit side.
（変形例１－４）
　図２１は、変形例１－４にかかるコンタクトレンズを示す断面図である。図２２は、図２１のＢ５矢視図である。図２１は、図２２のＣ５－Ｃ５線に対応する断面図である。軸Ａ５は、コンタクトレンズ１Ｄのレンズ幾何中心軸である。 (Modification 1-4)
FIG. 21 is a cross-sectional view showing the contact lens according to the modified example 1-4. FIG. 22 is a view taken along the line B5 of FIG. 21. FIG. 21 is a cross-sectional view corresponding to line C5-C5 of FIG. The axis A5 is the lens geometric center axis of the contact lens 1D.
　図２１、図２２に示すように、コンタクトレンズ１Ｄは、入射側導光窓２と傾斜角が異なる出射側導光窓３Ｄを備える。出射側導光窓３Ｄの傾斜角δは、入射側導光窓２の傾斜角γより大きい。その結果、出射側導光窓３Ｄからの光が被検体から離れる方向に進んで睫毛等に照射されることにより、迷光が発生することを防止することができる。 As shown in FIGS. 21 and 22, the contact lens 1D includes an exit side light guide window 3D having a different inclination angle from the incident side light guide window 2. The tilt angle δ of the light emitting window 3D is larger than the tilt angle γ of the light guide window 2 on the incident side. As a result, it is possible to prevent stray light from being generated by the light from the light emitting window 3D on the exit side traveling in the direction away from the subject and irradiating the eyelashes and the like.
（変形例１－５）
　図２３は、変形例１－５にかかるコンタクトレンズを示す断面図である。図２４は、図２３のＢ６矢視図である。図２３は、図２４のＣ６－Ｃ６線に対応する断面図である。軸Ａ６は、コンタクトレンズ１Ｅのレンズ幾何中心軸である。 (Modification example 1-5)
FIG. 23 is a cross-sectional view showing the contact lens according to the modified example 1-5. FIG. 24 is a view taken along the line B6 of FIG. 23. FIG. 23 is a cross-sectional view corresponding to line C6-C6 of FIG. 24. The axis A6 is the lens geometric center axis of the contact lens 1E.
　図２３、図２４に示すように、コンタクトレンズ１Ｅは、半円状の入射側導光窓２Ｃと傾斜角が異なる半円状の出射側導光窓３Ｅを備える。また、コンタクトレンズ１Ｅは、出射側導光窓３Ｅに付随して形成されている縁部４Ｅを備える。出射側導光窓３Ｅの傾斜角δは、入射側導光窓２Ｃの傾斜角γより大きい。その結果、出射側導光窓３Ｅからの光が被検体から離れる方向に進んで睫毛等に照射されることにより、迷光が発生することを防止することができる。 As shown in FIGS. 23 and 24, the contact lens 1E includes a semicircular incident side light guide window 2C and a semicircular exit side light guide window 3E having different inclination angles. Further, the contact lens 1E includes an edge portion 4E formed incidentally to the light emitting side light guide window 3E. The inclination angle δ of the light emitting window 3E is larger than the inclination angle γ of the light guide window 2C on the incident side. As a result, it is possible to prevent stray light from being generated by the light from the light emitting window 3E on the exit side traveling in the direction away from the subject and irradiating the eyelashes and the like.
（変形例１－６）
　図２５は、変形例１－６にかかるコンタクトレンズを示す断面図である。図２６は、図２５のＢ７矢視図である。図２５は、図２６のＣ７－Ｃ７線に対応する断面図である。軸Ａ７は、コンタクトレンズ１Ｆのレンズ幾何中心軸である。 (Modification example 1-6)
FIG. 25 is a cross-sectional view showing the contact lens according to the modified example 1-6. FIG. 26 is a view taken along the line B7 of FIG. 25. FIG. 25 is a cross-sectional view corresponding to line C7-C7 of FIG. The axis A7 is the lens geometric center axis of the contact lens 1F.
　図２５、図２６に示すように、コンタクトレンズ１Ｆは、連続的に形成されている入射側導光窓２Ｆ及び出射側導光窓３Ｆを備える。また、コンタクトレンズ１Ｆは、入射側導光窓２Ｆ及び出射側導光窓３Ｆに付随して形成されている縁部４Ｆを備える。入射側導光窓２Ｆは、中心角εで示す領域に形成されており、この部分では傾斜角はγで一定である。一方、出射側導光窓３Ｆでは、入射側導光窓２Ｆと接続する部分から徐々に傾斜角が大きくなり、入射側導光窓２Ｆと対向する端部で最大値のδとなる。その結果、出射側導光窓３Ｅからの光が被検体から離れる方向に進んで睫毛等に照射されることにより、迷光が発生することを防止することができる。 As shown in FIGS. 25 and 26, the contact lens 1F includes a continuously formed incident side light guide window 2F and an exit side light guide window 3F. Further, the contact lens 1F includes an incident side light guide window 2F and an edge portion 4F formed incidentally to the exit side light guide window 3F. The light guide window 2F on the incident side is formed in the region indicated by the central angle ε, and the inclination angle is constant at γ in this portion. On the other hand, in the light emitting window 3F, the inclination angle gradually increases from the portion connected to the light guide window 2F on the incident side, and the maximum value is δ at the end facing the light guide window 2F on the incident side. As a result, it is possible to prevent the generation of stray light due to the light from the light emitting window 3E on the exit side traveling in the direction away from the subject and irradiating the eyelashes and the like.
（変形例１－７）
　図２７は、変形例１－７にかかるコンタクトレンズを示す断面図である。図２８は、図２７のＢ８矢視図である。図２７は、図２８のＣ８－Ｃ８線に対応する断面図である。軸Ａ８は、コンタクトレンズ１Ｇのレンズ幾何中心軸である。 (Modification example 1-7)
FIG. 27 is a cross-sectional view showing the contact lens according to the modified example 1-7. FIG. 28 is a view taken along the line B8 of FIG. 27. FIG. 27 is a cross-sectional view corresponding to line C8-C8 of FIG. 28. The axis A8 is the lens geometric center axis of the contact lens 1G.
　図２７、図２８に示すように、コンタクトレンズ１Ｇは、入射側導光窓２及び出射側導光窓３の周囲に配置されており、光を遮光する遮光部５Ｇを備える。第１光源部２１からの励起光が入射側導光窓２から外れた場合、遮光部５Ｇによって励起光が遮光されるため、安全性が高い。また、房水１２を透過した光が出射側導光窓３から外れた場合、その光を遮光部５Ｇが遮光するため、予期しない迷光が発生することを防止することができる。 As shown in FIGS. 27 and 28, the contact lens 1G is arranged around the incident side light guide window 2 and the exit side light guide window 3, and includes a light shielding portion 5G that blocks light. When the excitation light from the first light source unit 21 deviates from the incident side light guide window 2, the excitation light is shielded by the light shielding unit 5G, so that the safety is high. Further, when the light transmitted through the aqueous humor 12 deviates from the light emitting side light guide window 3, the light shielding portion 5G blocks the light, so that it is possible to prevent unexpected stray light from being generated.
（変形例１－８）
　図２９は、変形例１－８にかかるコンタクトレンズを示す断面図である。図３０は、図２９のＢ９矢視図である。図２９は、図３０のＣ９－Ｃ９線に対応する断面図である。軸Ａ９は、コンタクトレンズ１Ｈのレンズ幾何中心軸である。 (Modification example 1-8)
FIG. 29 is a cross-sectional view showing the contact lens according to the modified example 1-8. FIG. 30 is a view taken along the line B9 of FIG. 29. FIG. 29 is a cross-sectional view corresponding to line C9-C9 of FIG. The axis A9 is the lens geometric center axis of the contact lens 1H.
　図２９、図３０に示すように、コンタクトレンズ１Ｈの中央部には、貫通孔６Ｈが形成されている。その結果、房水１２におけるラマン散乱光がコンタクトレンズ１Ｈで減衰することが防止されており、測定の精度が向上する。 As shown in FIGS. 29 and 30, a through hole 6H is formed in the central portion of the contact lens 1H. As a result, the Raman scattered light in the aqueous humor 12 is prevented from being attenuated by the contact lens 1H, and the measurement accuracy is improved.
〔房水ラマン分光計測装置の変形例〕
（変形例２－１）
　図３１は、変形例２－１にかかる房水ラマン分光計測システムの模式図である。図３１に示すように、房水ラマン分光計測装置２０Ａは、コリメートレンズ３２Ａを備える。このように、ノッチフィルタ２５の位置は、ハーフミラー２３と光ファイバ結合器２７との間の光が略平行な部分であればよい。 [Modification example of aqueous humor Raman spectroscopic measurement device]
(Modification 2-1)
FIG. 31 is a schematic diagram of the aqueous humor Raman spectroscopic measurement system according to the modified example 2-1. As shown in FIG. 31, the aqueous humor Raman spectroscopic measuring device 20A includes a collimating lens 32A. As described above, the position of the notch filter 25 may be a portion where the light between the half mirror 23 and the optical fiber coupler 27 is substantially parallel.
　なお、上述した実施の形態では、ハーフミラー２３を透過した光を分光器２９により計測する例を示したが、ハーフミラー２３が反射した光を分光器２９により計測してもよい。 In the above-described embodiment, the light transmitted through the half mirror 23 is measured by the spectroscope 29, but the light reflected by the half mirror 23 may be measured by the spectroscope 29.
　また、上述した実施の形態では、コンタクトレンズ１を用いて、ラマン散乱光を計測する例を説明したが、これに限られない。中心軸Ａ１と略直交する方向から入射側導光窓２に励起光を入射し、出射側導光窓３によってコンタクトレンズ１の外部に導光された光を計測してもよい。この計測方法により、例えば、赤外分光法によって房水１２に含まれる物質を分析してもよい。 Further, in the above-described embodiment, an example of measuring Raman scattered light using the contact lens 1 has been described, but the present invention is not limited to this. The excitation light may be incident on the incident side light guide window 2 from a direction substantially orthogonal to the central axis A1, and the light guided to the outside of the contact lens 1 by the exit side light guide window 3 may be measured. By this measurement method, for example, the substance contained in the aqueous humor 12 may be analyzed by infrared spectroscopy.
　１、１Ａ、１Ｂ、１Ｃ、１Ｄ、１Ｅ、１Ｆ、１Ｇ、１Ｈ　コンタクトレンズ
　１ａ　内面
　１ｂ　外面
　２、２Ｃ、２Ｆ　入射側導光窓
　２Ｂ　導光窓
　３、３Ｄ、３Ｅ、３Ｆ　出射側導光窓
　４、４Ｂ、４Ｃ、４Ｅ、４Ｆ　縁部
　５Ｇ　遮光部
　６Ｈ　貫通孔
　１０　被検眼
　１１　角膜
　１１ａ　角膜上皮
　１１ｂ　角膜内皮
　１２　房水
　２０　房水ラマン分光計測装置
　２１　第１光源部
　２２　遮光部材
　２３　ハーフミラー
　２４　対物レンズ
　２５　ノッチフィルタ
　２６　集光レンズ
　２７　光ファイバ結合器
　２８　光ファイバ
　２９　分光器
　３０　第２光源部
　３１　カメラ
　３２Ａ　コリメートレンズ
　１００　房水ラマン分光計測システム 1, 1A, 1B, 1C, 1D, 1E, 1F, 1G, 1H Contact lens 1a Inner surface 1b Outer surface 2, 2C, 2F Incident side light guide window 2B Light guide window 3, 3D, 3E, 3F Exit side light guide window 4 4B, 4C, 4E, 4F Edge 5G Light-shielding part 6H Through-hole 10 Eye to be inspected 11 Corneal 11a Corneal epithelium 11b Corneal endothelium 12 Tufts 20 Tufts Raman spectrophotometer 21 First light source 22 Shading member 23 Half mirror 24 Objective Lens 25 Notch filter 26 Condensing lens 27 Optical fiber coupler 28 Optical fiber 29 Spectrometer 30 Second light source 31 Camera 32A Collimating lens 100 Bunched Raman spectroscopic measurement system

Claims (13)

  1. 　被検眼に接する凹型の内面と、凸型の外面とを備えるコンタクトレンズであって、
    　前記外面から前記内面側に切り欠かれて形成されており、レンズ幾何中心軸と略直交する方向から入射した光が、当該コンタクトレンズを装用した前記被検眼の房水内において、前記レンズ幾何中心軸と略直交する方向に沿って進むように導光する入射側導光窓を備えることを特徴とするコンタクトレンズ。     A contact lens having a concave inner surface and a convex outer surface in contact with the eye to be inspected.
    Light that is cut out from the outer surface to the inner surface side and is incident from a direction substantially orthogonal to the lens geometric center axis is emitted from the lens geometric center in the aqueous humor of the eye to be inspected wearing the contact lens. A contact lens characterized by including an incident side light guide window that guides light so as to travel in a direction substantially orthogonal to the axis.
  2. 　前記入射側導光窓は、前記レンズ幾何中心軸とのなす角が８°以上２８°以下であることを特徴とする請求項１に記載のコンタクトレンズ。 The contact lens according to claim 1, wherein the incident side light guide window has an angle formed by the lens geometric center axis of 8 ° or more and 28 ° or less.
  3. 　当該コンタクトレンズの屈折率は、１．３６以上１．４６以下であることを特徴とする請求項１又は２に記載のコンタクトレンズ。 The contact lens according to claim 1 or 2, wherein the refractive index of the contact lens is 1.36 or more and 1.46 or less.
  4. 　前記レンズ幾何中心軸を対称軸として、前記入射側導光窓と線対称の位置に形成されている出射側導光窓であって、前記外面から前記内面側に切り欠かれて形成されており、当該コンタクトレンズを装用した前記被検眼の前記房水を透過した光を当該コンタクトレンズの外部に導光する出射側導光窓を備えることを特徴とする請求項１～３のいずれか１つに記載のコンタクトレンズ。 An exit-side light guide window formed at a position line-symmetrical with the incident-side light guide window with the lens geometric center axis as the axis of symmetry, and is formed by being cut out from the outer surface to the inner surface side. One of claims 1 to 3, further comprising an exit-side light guide window that guides light transmitted through the aqueous humor of the eye to be inspected wearing the contact lens to the outside of the contact lens. Contact lenses described in.
  5. 　前記入射側導光窓の周囲に配置されており、光を遮光する遮光部を備えることを特徴とする請求項１～４のいずれか１つに記載のコンタクトレンズ。 The contact lens according to any one of claims 1 to 4, which is arranged around the light guide window on the incident side and includes a light-shielding portion that blocks light.
  6. 　当該コンタクトレンズの中央部に貫通孔が形成されていることを特徴とする請求項１～５のいずれか１つに記載のコンタクトレンズ。 The contact lens according to any one of claims 1 to 5, wherein a through hole is formed in the central portion of the contact lens.
  7. 　励起光を出射する第１光源部と、
    　前記励起光の光軸と略直交する方向に配置されているハーフミラーと、
    　前記ハーフミラーを透過した前記励起光の被検眼の房水に含まれている物質による散乱光又は前記ハーフミラーで反射した前記散乱光の一方の光路上に配置されており、前記散乱光に含まれるレイリー散乱光と同じ波長の光を遮光し、前記散乱光に含まれるラマン散乱光を透過するフィルタと、
    　前記フィルタを透過した光を分光計測する分光器と、
    　前記ハーフミラーを透過した前記散乱光又は前記ハーフミラーで反射した前記散乱光の他方の光路上に配置されており、光を出射して前記被検眼を固視させるための第２光源部と、
    　を備えることを特徴とする房水ラマン分光計測装置。     The first light source unit that emits excitation light and
    A half mirror arranged in a direction substantially orthogonal to the optical axis of the excitation light, and
    The excitation light transmitted through the half mirror is arranged on one of the scattered light by a substance contained in the aqueous humor of the eye to be inspected or the scattered light reflected by the half mirror, and is included in the scattered light. A filter that blocks light of the same wavelength as Rayleigh scattered light and transmits Raman scattered light contained in the scattered light.
    A spectroscope that spectroscopically measures the light transmitted through the filter and
    A second light source unit which is arranged on the other light path of the scattered light transmitted through the half mirror or the scattered light reflected by the half mirror and for emitting light to fix the eye to be inspected.
    Aqueous humor Raman spectroscopic measurement device characterized by being equipped with.
  8. 　前記第２光源部は、前記フィルタに遮光される波長の光を出射することを特徴とする請求項７に記載の房水ラマン分光計測装置。 The aqueous humor Raman spectroscopic measurement device according to claim 7, wherein the second light source unit emits light having a wavelength that is shielded from light by the filter.
  9. 　前記第２光源部は、白色光を出射することを特徴とする請求項７又は８に記載の房水ラマン分光計測装置。 The aqueous humor Raman spectroscopic measurement device according to claim 7 or 8, wherein the second light source unit emits white light.
  10. 　前記被検眼と前記ハーフミラーとの間において、前記第２光源部が出射する光の光軸は、前記分光器に入射する光の光軸から略５°ずれていることを特徴とする請求項７～９のいずれか１つに記載の房水ラマン分光計測装置。 The claim is characterized in that the optical axis of the light emitted by the second light source unit is deviated by approximately 5 ° from the optical axis of the light incident on the spectroscope between the eye to be inspected and the half mirror. The aqueous Raman spectroscopic measuring apparatus according to any one of 7 to 9.
  11. 　被検眼に接する凹型の内面と、凸型の外面とを備えるコンタクトレンズであって、前記外面から前記内面側に切り欠かれて形成されており、レンズ幾何中心軸と略直交する方向から入射した光が、当該コンタクトレンズを装用した前記被検眼の房水内において、前記レンズ幾何中心軸と略直交する方向に沿って進むように導光する入射側導光窓を有するコンタクトレンズと、
    　前記入射側導光窓に対して前記レンズ幾何中心軸と略直交する方向から入射するように励起光を出射する第１光源部と、
    　前記励起光の光軸と略直交する方向に配置されているハーフミラーと、
    　前記ハーフミラーを透過した前記励起光の前記被検眼の前記房水に含まれている物質による散乱光又は前記ハーフミラーで反射した前記散乱光の一方の光路上に配置されており、前記散乱光に含まれるレイリー散乱光と同じ波長の光を遮光し、前記散乱光に含まれるラマン散乱光を透過するフィルタと、
    　前記フィルタを透過した光を分光計測する分光器と、
    　前記ハーフミラーを透過した前記散乱光又は前記ハーフミラーで反射した前記散乱光の他方の光路上に配置されており、光を出射して前記被検眼を固視させるための第２光源部と、
    　を備えることを特徴とする房水ラマン分光計測システム。     A contact lens having a concave inner surface in contact with an eye to be inspected and a convex outer surface, which is formed by being cut out from the outer surface to the inner surface side, and is incident from a direction substantially orthogonal to the geometric center axis of the lens. A contact lens having an incident side light guide window that guides light so as to travel in a bunch of water of the eye to be inspected wearing the contact lens in a direction substantially orthogonal to the geometric center axis of the lens.
    A first light source unit that emits excitation light so as to be incident on the incident side light guide window from a direction substantially orthogonal to the lens geometric center axis.
    A half mirror arranged in a direction substantially orthogonal to the optical axis of the excitation light, and
    The excitation light transmitted through the half mirror is arranged on one of the light paths of the scattered light due to the substance contained in the bunch of water of the eye to be inspected or the scattered light reflected by the half mirror, and the scattered light. A filter that blocks light of the same wavelength as the Rayleigh scattered light contained in the above and transmits the Raman scattered light contained in the scattered light.
    A spectroscope that spectroscopically measures the light transmitted through the filter and
    A second light source unit which is arranged on the other light path of the scattered light transmitted through the half mirror or the scattered light reflected by the half mirror and for emitting light to fix the eye to be inspected.
    Aqueous humor Raman spectroscopic measurement system characterized by being equipped with.
  12. 　被検眼に接する凹型の内面と、凸型の外面とを備えるコンタクトレンズであって、前記外面から前記内面側に切り欠かれて形成されており、レンズ幾何中心軸と略直交する方向から入射した光が、当該コンタクトレンズを装用した前記被検眼の房水内において、前記レンズ幾何中心軸と略直交する方向に沿って進むように導光する入射側導光窓を有するコンタクトレンズを装用した前記被検眼の前記房水に含まれている物質によるラマン散乱光を計測する房水ラマン分光計測方法であって、
    　第１光源部から出射した励起光が前記入射側導光窓に対して前記レンズ幾何中心軸と略直交する方向から入射するように位置合わせを行う位置合わせステップと、
    　第２光源部から前記被検眼に光を出射して前記被検眼を固視させる固視ステップと、
    　前記第１光源部から前記励起光を出射し、前記励起光の前記被検眼の前記房水に含まれている物質による散乱光に含まれるレイリー散乱光と同じ波長の光を遮光し、前記散乱光に含まれるラマン散乱光を透過するフィルタを透過した光を分光器により分光計測する計測ステップと、
    　を含むことを特徴とする房水ラマン分光計測方法。     A contact lens having a concave inner surface in contact with an eye to be inspected and a convex outer surface, which is formed by being cut out from the outer surface to the inner surface side, and is incident from a direction substantially orthogonal to the geometric center axis of the lens. The contact lens having an incident side light guide window that guides light so as to travel along a direction substantially orthogonal to the geometric center axis of the lens in the aqueous chamber of the eye to be inspected wearing the contact lens. It is a bunch water Raman spectroscopic measurement method for measuring Raman scattered light by a substance contained in the bunch water of the eye to be inspected.
    An alignment step of aligning the excitation light emitted from the first light source unit so that the excitation light is incident on the incident side light guide window from a direction substantially orthogonal to the lens geometric center axis.
    A fixation step in which light is emitted from the second light source unit to the eye to be inspected to fix the eye to be inspected.
    The excitation light is emitted from the first light source unit, and the light having the same wavelength as the Rayleigh scattered light contained in the scattered light by the substance contained in the bunch of water of the eye to be inspected is blocked, and the scattering is performed. A measurement step of spectroscopically measuring the light transmitted through a filter that transmits Raman scattered light contained in the light with a spectroscope, and
    Aqueous humor Raman spectroscopic measurement method, which comprises.
  13. 　前記コンタクトレンズは、前記レンズ幾何中心軸を対称軸として、前記入射側導光窓と線対称の位置に形成されている出射側導光窓であって、前記外面から前記内面側に切り欠かれて形成されており、当該コンタクトレンズを装用した前記被検眼の前記房水を透過した光を当該コンタクトレンズの外部に導光する出射側導光窓を有し、
    　前記計測ステップの前に、前記第１光源部から前記励起光より光強度が小さい透過検査光を出射し、前記入射側導光窓に入射した前記透過検査光が前記出射側導光窓から出射するか否かを検査する透過検査ステップを含むことを特徴とする請求項１２に記載の房水ラマン分光計測方法。     The contact lens is an exit-side light guide window formed at a position line-symmetrical with the incident-side light guide window with the lens geometric center axis as the axis of symmetry, and is cut out from the outer surface to the inner surface side. It has an exit side light guide window that guides the light transmitted through the bunch of water of the eye to be inspected to the outside of the contact lens.
    Prior to the measurement step, transmission inspection light having a light intensity smaller than that of the excitation light is emitted from the first light source unit, and the transmission inspection light incident on the incident side light guide window is emitted from the exit side light guide window. The aqueous Raman spectroscopic measurement method according to claim 12, further comprising a permeation inspection step of inspecting whether or not to do so.
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