AU2001259635B2 - Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation - Google Patents

Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation Download PDF

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Publication number
AU2001259635B2
AU2001259635B2 AU2001259635A AU2001259635A AU2001259635B2 AU 2001259635 B2 AU2001259635 B2 AU 2001259635B2 AU 2001259635 A AU2001259635 A AU 2001259635A AU 2001259635 A AU2001259635 A AU 2001259635A AU 2001259635 B2 AU2001259635 B2 AU 2001259635B2
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AU
Australia
Prior art keywords
embryo
fluid
fluid channel
embryos
channel
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Ceased
Application number
AU2001259635A
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English (en)
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AU2001259635A1 (en
Inventor
David J. Beebe
Ian K. Glasgow
Matthew B. Wheeler
Henry Zeringue
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University of Illinois
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University of Illinois
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Filing date
Publication date
Priority claimed from US09/570,483 external-priority patent/US6695765B1/en
Application filed by University of Illinois filed Critical University of Illinois
Publication of AU2001259635A1 publication Critical patent/AU2001259635A1/en
Application granted granted Critical
Publication of AU2001259635B2 publication Critical patent/AU2001259635B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00Bioreactors or fermenters specially adapted for specific uses
    • C12M21/06Bioreactors or fermenters specially adapted for specific uses for in vitro fertilization
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/16Microfluidic devices; Capillary tubes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0636Focussing flows, e.g. to laminate flows
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668Trapping microscopic beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/084Passive control of flow resistance
    • B01L2400/086Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Fluid Mechanics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2001259635A 2000-05-12 2001-05-08 Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation Ceased AU2001259635B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/570,483 2000-05-12
US09/570,483 US6695765B1 (en) 1999-04-08 2000-05-12 Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation
PCT/US2001/014822 WO2001088087A2 (en) 2000-05-12 2001-05-08 Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation

Publications (2)

Publication Number Publication Date
AU2001259635A1 AU2001259635A1 (en) 2002-02-14
AU2001259635B2 true AU2001259635B2 (en) 2005-05-19

Family

ID=24279818

Family Applications (2)

Application Number Title Priority Date Filing Date
AU5963501A Pending AU5963501A (en) 2000-05-12 2001-05-08 Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation
AU2001259635A Ceased AU2001259635B2 (en) 2000-05-12 2001-05-08 Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU5963501A Pending AU5963501A (en) 2000-05-12 2001-05-08 Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation

Country Status (11)

Country Link
EP (1) EP1280465A4 (es)
JP (1) JP2003533221A (es)
KR (1) KR20030009482A (es)
CN (1) CN1441652A (es)
AU (2) AU5963501A (es)
BR (1) BR0110768A (es)
CA (1) CA2408616C (es)
IL (1) IL152650A (es)
MX (1) MXPA02011150A (es)
RU (1) RU2002130577A (es)
WO (1) WO2001088087A2 (es)

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CA2480728A1 (en) * 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
JP2007501633A (ja) * 2003-05-06 2007-02-01 ベル ブルック ラブズ リミテッド ライアビリティ カンパニー 微小規模の流体ハンドリングシステムにおける三次元細胞培養
WO2004108011A1 (en) * 2003-06-06 2004-12-16 The Regents Of The University Of Michigan Integrated microfluidic sperm isolation and insemination device
GB0321158D0 (en) * 2003-09-10 2003-10-08 Central Research Lab Ltd Apparatus and method for handling cells,embryos or oocytes
EP1609850A1 (en) 2004-06-24 2005-12-28 Biovir v/Jacob Mollenbach Culture dish for culturing biological cells
JP2006055072A (ja) * 2004-08-20 2006-03-02 Fujitsu Ltd 搬送制御装置及び方法
US20090004730A1 (en) * 2005-03-18 2009-01-01 Nao Nitta Cell Obsevation Aiding Instrument and Method of Cell Observation Therewith
GB0508983D0 (en) 2005-05-03 2005-06-08 Oxford Gene Tech Ip Ltd Cell analyser
US20070084706A1 (en) * 2005-10-18 2007-04-19 Shuichi Takayama Microfluidic cell culture device and method for using same
US20070090166A1 (en) * 2005-10-18 2007-04-26 Shuichi Takayama Microfluidic cell culture device
US20110104730A1 (en) * 2007-08-24 2011-05-05 Smart Biosystems Aps Mesoscale bioreactor platform for perfusion
TW200920841A (en) * 2007-09-25 2009-05-16 Cytyc Corp Microfluidic apparatus for manipulating imaging and analyzing cells of a cytological specimen
KR100891487B1 (ko) * 2007-11-01 2009-04-01 한국과학기술원 미세유체제어기술 기반으로 한 난모세포 또는 난자의 핵제거 시스템
WO2009079474A1 (en) * 2007-12-14 2009-06-25 The University Of North Carolina At Chapel Hill Methods, systems, and computer readable media for facilitating automation of blastocyst microinjection
EP2318505A1 (en) * 2008-08-01 2011-05-11 Smart Biosystems APS A chamber of a bioreactor platform
GB2464300A (en) * 2008-10-10 2010-04-14 Univ Dublin City Microfluidic multiplexed cellular and molecular analysis device and method
GB0821636D0 (en) 2008-11-26 2008-12-31 Ucl Business Plc Device
WO2010141320A1 (en) * 2009-06-01 2010-12-09 Mariposa Biotechnology, Inc. Device for removing cumulus from oocytes
US8621943B2 (en) * 2009-09-30 2014-01-07 Weyerhaeuser Nr Company Method of singulating embryos
EP2316565A1 (en) * 2009-10-26 2011-05-04 Fei Company A micro-reactor for observing particles in a fluid
CN101947124B (zh) * 2010-06-25 2012-07-04 博奥生物有限公司 一种集成式微流控芯片装置及其使用方法
EP2621344B1 (en) * 2010-09-27 2023-12-27 Ares Trading S.A. Apparatus, method, and system for the automated imaging and evaluation of embryos, oocytes, and stem cells
ES2725825T3 (es) * 2012-04-16 2019-09-27 Univ Cornell Sistema de fertilización asistida por inyección de esperma intracitoplasmática automatizada
US10371622B2 (en) 2013-03-14 2019-08-06 Inguran, Llc Device for high throughput sperm sorting
US10662408B2 (en) 2013-03-14 2020-05-26 Inguran, Llc Methods for high throughput sperm sorting
US9757726B2 (en) 2013-03-14 2017-09-12 Inguran, Llc System for high throughput sperm sorting
AU2015203738B2 (en) * 2013-03-14 2017-10-05 Inguran, Llc Apparatus and methods for high throughput sperm sorting
AU2013202635B2 (en) * 2013-03-14 2015-10-29 Inguran, Llc Apparatus and methods for high throughput sperm sorting
GB201512600D0 (en) * 2015-07-17 2015-08-26 Koniku Ltd Cell culture, transport and investigation
WO2018208332A2 (en) 2017-02-17 2018-11-15 Koniku, Inc. Systems for detection
KR101959208B1 (ko) * 2017-05-24 2019-03-19 한국기계연구원 액적기반 바이오칩, 이를 이용한 종양 생산방법, 및 이를 통해 생산된 종양의 전이성 판단방법
US20210161635A1 (en) * 2018-04-04 2021-06-03 The General Hospital Corporation Microfluidic Systems and Methods to Denude Mammalian Oocytes
WO2020005802A1 (en) * 2018-06-24 2020-01-02 University Of Oregon Microinjection chip, device, system and uses thereof for unicellular or multicellular organisms
FR3084121B1 (fr) * 2018-07-17 2021-01-15 Skf Aerospace France Assemblage mecanique et dispositif mecanique
CN111073817A (zh) * 2018-10-22 2020-04-28 曾繁根 用于精子分选、卵子培育、体外受精的整合式晶片及方法
CN111378556A (zh) * 2018-12-29 2020-07-07 青岛华大智造普惠科技有限公司 微流控芯片及其制备方法、单细胞微液滴的制备方法
WO2020242860A1 (en) * 2019-05-24 2020-12-03 University Of Houston System Apparatus and methods for medical applications of laser driven microfluid pumps
KR102267433B1 (ko) * 2019-07-29 2021-06-21 연세대학교 산학협력단 세포배양 플레이트
KR102243812B1 (ko) * 2019-08-13 2021-04-22 경희대학교 산학협력단 체외수정 자동화 장치 및 그것의 동작 방법
DE102020214862B4 (de) * 2020-11-26 2022-08-04 Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Körperschaft des öffentlichen Rechts System und Vorrichtung zur Charakterisierung von Veränderungen des Reifungsvorgangs einer Eizelle, sowie deren Verwendung
CN117660183B (zh) * 2024-01-31 2024-04-16 山东大学 胚胎微流控动态培养皿及其培养方法

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US6193647B1 (en) * 1999-04-08 2001-02-27 The Board Of Trustees Of The University Of Illinois Microfluidic embryo and/or oocyte handling device and method

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Patent Citations (1)

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US6193647B1 (en) * 1999-04-08 2001-02-27 The Board Of Trustees Of The University Of Illinois Microfluidic embryo and/or oocyte handling device and method

Also Published As

Publication number Publication date
CA2408616A1 (en) 2001-11-22
RU2002130577A (ru) 2004-03-27
EP1280465A2 (en) 2003-02-05
BR0110768A (pt) 2003-03-11
WO2001088087A2 (en) 2001-11-22
IL152650A (en) 2006-12-31
WO2001088087A3 (en) 2002-03-28
EP1280465A4 (en) 2004-10-20
CA2408616C (en) 2007-10-02
KR20030009482A (ko) 2003-01-29
CN1441652A (zh) 2003-09-10
AU5963501A (en) 2001-11-26
JP2003533221A (ja) 2003-11-11
IL152650A0 (en) 2003-06-24
MXPA02011150A (es) 2004-08-19

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